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UPdAl is a heavy-fermion superconductor with a hexagonal crystal structure and critical temperature T=2.0K that was discovered in 1991. Furthermore, UPdAl orders antiferromagnetically at T=14K, and UPdAl thus features the unusual behavior that this material, at temperatures below 2K, is simultaneously superconducting a...
0
Metallurgy
One short inscription on the pillar is associated with the Tomara king Anangpal, although it is hard to decipher.. Alexander Cunningham (1862–63) read the inscription as follows: Based on this reading, Cunningham theorized that Anangpal had moved the pillar to its current location while establishing the city of Delhi. ...
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Metallurgy
Alternative splicing was first observed in 1977. The adenovirus produces five primary transcripts early in its infectious cycle, prior to viral DNA replication, and an additional one later, after DNA replication begins. The early primary transcripts continue to be produced after DNA replication begins. The additional p...
1
Gene expression + Signal Transduction
The idea of interstitial compounds was started in the late 1930s and they are often called Hagg phases after Hägg. Transition metals generally crystallise in either the hexagonal close packed or face centered cubic structures, both of which can be considered to be made up of layers of hexagonally close packed atoms. In...
0
Metallurgy
The candidate division SR1 and gracilibacteria code (translation table 25) is used in two groups of (so far) uncultivated bacteria found in marine and fresh-water environments and in the intestines and oral cavities of mammals among others. The difference to the standard and the bacterial code is that UGA represents ...
1
Gene expression + Signal Transduction
Shape-memory alloys are typically made by casting, using vacuum arc melting or induction melting. These are specialist techniques used to keep impurities in the alloy to a minimum and ensure the metals are well mixed. The ingot is then hot rolled into longer sections and then drawn to turn it into wire. The way in whic...
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Metallurgy
"Upper bainite" forms around 400–550 °C in sheaves. These sheaves contain several laths of ferrite that are approximately parallel to each other and which exhibit a Kurdjumov-Sachs relationship with the surrounding austenite, though this relationship degrades as the transformation temperature is lowered. The ferrite ...
0
Metallurgy
The lost-wax casting process may also be used in the production of cast glass sculptures. The original sculpture is made from wax. The sculpture is then covered with mold material (e.g., plaster), except for the bottom of the mold which must remain open. When the mold has hardened, the encased sculpture is removed by a...
0
Metallurgy
The first period of metallurgical production in the Urals date back to the 4th and 3rd millennia BC. During the Bronze Age, primitive copper-bronze metallurgy was developed among the pastoral tribes of the Urals. The beginning of the development of the Kargalinsky copper ore deposit, located along the Kargalka and Yang...
0
Metallurgy
Efficient ribosomal frameshifting generally requires the presence of an RNA secondary structure to enhance the effects of the slippery sequence. The RNA structure (which can be a stem-loop or pseudoknot) is thought to pause the ribosome on the slippery site during translation, forcing it to relocate and continue replic...
1
Gene expression + Signal Transduction
ppGpp inhibits IF2-mediated fMet-Phe initiation dipeptide formation, probably by interfering with 30S and 50S subunit interactions. E. coli accumulates more ppGpp than pppGpp during amino acid starvation, and ppGpp has about 8-fold greater efficiency than that of pppGpp. While B. subtilis accumulates more pppGpp than p...
1
Gene expression + Signal Transduction
The Schikorr reaction formally describes the conversion of the iron(II) hydroxide (Fe(OH)) into iron(II,III) oxide (FeO). This transformation reaction was first studied by Gerhard Schikorr. The global reaction follows: It is of special interest in the context of the serpentinization, the formation of hydrogen by the ac...
0
Metallurgy
Christian Alfred Elie Janot (January 4, 1936 – February 23, 2022) was a French physicist and materials scientist known for his work on materials characterization using Mössbauer spectroscopy and his physical metallurgy studies of quasicrystals and noncrystalline materials using neutron scattering techniques.
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Metallurgy
The South Turkmenistan Complex Archaeological Expedition (STACE), also called the South Turkmenistan Archaeological Inter-disciplinary Expedition of the Academy of Sciences of the Turkmen Soviet Socialist Republic (YuTAKE) was endorsed by the Turkmenistan Academy of Sciences. It was initially organized by the orientali...
0
Metallurgy
Inositol phosphates are a group of mono- to hexaphosphorylated inositols. Each form of inositol phosphate is distinguished by the number and position of the phosphate group on the inositol ring. * inositol monophosphate (IP) * inositol bisphosphate (IP) * inositol trisphosphate (IP) * inositol tetrakisphosphate (IP) * ...
1
Gene expression + Signal Transduction
The advantages of reverse transfection (over conventional transfection) are: *The addition and attachment of target cells to the DNA-loaded surface can lead to a higher probability of cell-DNA contact, potentially leading to higher transfection efficiency. *Labour-saving materials (less DNA is required) *High-throughp...
1
Gene expression + Signal Transduction
The Mission of the International Deep Drawing Research Group ([http://www.iddrg.com IDDRG]) is to co-ordinate research and development work in sheet metal forming, to bring together scientists, researchers and industrialists working on these fields all over the World, to provide open and scientifically highly acknowled...
0
Metallurgy
OJSC Dolomite () forms part of the Russia metallurgical complex, being the only producer of metallurgical dolomite in the Central Black Earth economic region. The company mines 55% of the total amount of dolomite produced in Russia and 43% in CIS. It is part of the NLMK Group. The company has explored the Dankov dolomi...
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Metallurgy
* Brody, David. Labor in Crisis: The Steel Strike of 1919 (1965) * Mary Margaret Fonow; Union Women: Forging Feminism in the United Steelworkers of America (University of Minnesota Press, 2003) * [https://web.archive.org/web/20110717180737/http://www.ussteel.com/corp/about.htm#The%20History%20of%20United%20States%20St...
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Metallurgy
Specific mutations in different splice sites in various genes that cause inherited disorders, including, for example, Type 1 diabetes (e.g., PTPN22, TCF1 (HCF-1A)), hypertension (e.g., LDL, LDLR, LPL), Marfan syndrome (e.g., FBN1, TGFBR2, FBN2), cardiac diseases (e.g., COL1A2, MYBPC3, ACTC1), eye disorders (e.g., EVC, ...
1
Gene expression + Signal Transduction
The active zone or synaptic active zone is a term first used by Couteaux and Pecot-Dechavassinein in 1970 to define the site of neurotransmitter release. Two neurons make near contact through structures called synapses allowing them to communicate with each other. As shown in the adjacent diagram, a synapse consists o...
1
Gene expression + Signal Transduction
Autoclave reactors are used for reactions at higher temperatures, which can enhance the rate of the reaction. Similarly, autoclaves enable the use of gaseous reagents in the system.
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Metallurgy
In the early 17th century, ironworkers in Western Europe had developed the cementation process for carburizing wrought iron. Wrought iron bars and charcoal were packed into stone boxes, then sealed with clay to be held at a red heat continually tended in an oxygen-free state immersed in nearly pure carbon (charcoal) fo...
0
Metallurgy
Concrete cancer may refer to: * Rebar corrosion and spalling of the concrete cover above rebar caused by the rust expansion and accelerated by chloride attack and pitting corrosion of the steel reinforcements. * Alkali–silica reaction (ASR), also known as alkali-aggregate reaction (AAR), when reactive amorphous silic...
0
Metallurgy
Given the short sequences of most promoter elements, promoters can rapidly evolve from random sequences. For instance, in E. coli, ~60% of random sequences can evolve expression levels comparable to the wild-type lac promoter with only one mutation, and that ~10% of random sequences can serve as active promoters even w...
1
Gene expression + Signal Transduction
There are several methods that can be used as an alternative to FAIRE-seq. DNase-seq uses the ability of the DNase I enzyme to cleave free/open/accessible DNA to identify and sequence open chromatin. The subsequently developed ATAC-seq employs the Tn5 transposase, which inserts specified fragments or transposons into a...
1
Gene expression + Signal Transduction
Oxygen is one of the reagents consumed during cyanidation, accepting the electrons from the gold, and a deficiency in dissolved oxygen slows leaching rate. Air or pure oxygen gas can be purged through the pulp to maximize the dissolved oxygen concentration. Intimate oxygen-pulp contactors are used to increase the parti...
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Metallurgy
Ferrophosphorus is a ferroalloy, an alloy of iron and phosphorus. It contains high proportion of iron phosphides, FeP and FeP. Its CAS number is 8049-19-2. The usual grades contain either 18 or 25% of phosphorus. It is a gray solid material with melting point between 1050-1100 °C. It may liberate phosphine in contact w...
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Metallurgy
Grain boundary engineering involves manipulating the grain boundary structure and energy to enhance mechanical properties. By controlling the interfacial energy, it is possible to engineer materials with desirable grain boundary characteristics, such as increased interfacial area, higher grain boundary density, or spec...
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Metallurgy
Adam17 may facilitate entry of the SARS‑CoV‑2 virus, possibly by enabling fusion of virus particles with the cytoplasmic membrane. Adam17 has similar ACE2 cleavage activity as TMPRSS2, but by forming soluble ACE2, Adam17 may actually have the protective effect of blocking circulating SARS‑CoV‑2 virus particles. Adam17...
1
Gene expression + Signal Transduction
Ribozymes are catalytic RNA molecules used to inhibit gene expression. These molecules work by cleaving mRNA molecules, essentially silencing the genes that produced them. Sidney Altman and Thomas Cech first discovered catalytic RNA molecules, RNase P and group II intron ribozymes, in 1989 and won the Nobel Prize for t...
1
Gene expression + Signal Transduction
The term co-receptor is prominent in literature regarding signal transduction, the process by which external stimuli regulate internal cellular functioning. The key to optimal cellular functioning is maintained by possessing specific machinery that can carry out tasks efficiently and effectively. Specifically, the proc...
1
Gene expression + Signal Transduction
The purification process utilizes the cementation process to further purify the zinc. It uses zinc dust and steam to remove copper, cadmium, cobalt, and nickel, which would interfere with the electrolysis process. After purification, concentrations of these impurities are limited to less than 0.05 milligram per liter (...
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Metallurgy
ROP proteins are a type of monomeric G proteins found in plants belonging to the Rho family. ROP binding to GTP or GDP determines its activity due to conformational changes within its structure. Within the G-domain of the structure are the G-box motifs G1-5. These motifs are formed during protein folding and are compos...
1
Gene expression + Signal Transduction
The practice of using colours to determine the temperature of a piece of (usually) ferrous metal comes from blacksmithing. Long before thermometers were widely available, it was necessary to know what state the metal was in for heat treating it and the only way to do this was to heat it up to a colour which was known t...
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Metallurgy
RPB3 is involved in RNA polymerase II assembly. A subcomplex of RPB2 and RPB3 appears soon after subunit synthesis. This complex subsequently interacts with RPB1. RPB3, RPB5, and RPB7 interact with themselves to form homodimers, and RPB3 and RPB5 together are able to contact all of the other RPB subunits, except RPB9. ...
1
Gene expression + Signal Transduction
The exact temperatures at which iron will transition from one crystal structure to another depends on how much and what type of other elements are dissolved in the iron. The phase boundary between the different solid phases is drawn on a binary phase diagram, usually plotted as temperature versus percent iron. Adding s...
0
Metallurgy
The core was probably originally compiled around AD 600, perhaps in Alexandria in Egypt, in Greek. The core contains items traceable to earlier Alexandrian Greek texts, particularly the Stockholm papyrus and Leiden Papyrus X, which are Greek texts dated to the 2nd or 3rd century AD that contain some of the same and sim...
0
Metallurgy
FK phase materials have been pointed out for their high-temperature structure and as superconducting materials. Their complex and often non-stoichiometric structure makes them good subjects for theoretical calculations. A15, Laves and σ are the most applicable FK structures with interesting fundamental properties. The ...
0
Metallurgy
Organic chemicals such as lactic acid and citric acid have been used to etch metals and create products as early as 400 BCE, when vinegar was used to corrode lead and create the pigment ceruse, also known as white lead. Most modern chemical milling methods involve alkaline etchants; these may have been used as early as...
0
Metallurgy
The first reported steps towards the discovery of the shape-memory effect were taken in the 1930s. According to Otsuka and Wayman, Arne Ölander discovered the pseudoelastic behavior of the Au-Cd alloy in 1932. Greninger and Mooradian (1938) observed the formation and disappearance of a martensitic phase by decreasing a...
0
Metallurgy
Currently, the stability of most ionic liquids under practical electrochemical conditions is unknown, and the fundamental choice of ionic fluid is still empirical as there is almost no data on metal ion thermodynamics to feed into solubility and speciation models. Also, there are no Pourbaix diagrams available, no stan...
0
Metallurgy
Bases: adenine (A), cytosine (C), guanine (G) and thymine (T) or uracil (U). Amino acids: Alanine (Ala, A), Arginine (Arg, R), Asparagine (Asn, N), Aspartic acid (Asp, D), Cysteine (Cys, C), Glutamic acid (Glu, E), Glutamine (Gln, Q), Glycine (Gly, G), Histidine (His, H), Isoleucine (Ile, I), Leucine (Leu, L), Lysine (...
1
Gene expression + Signal Transduction
Due to its ease of operation and its usefulness in polishing irregularly-shaped objects, electropolishing has become a common process in the production of semiconductors. As electropolishing can also be used to sterilize workpieces, the process plays an essential role in the food, medical, and pharmaceutical industries...
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Metallurgy
Hormone producing cells are found in the endocrine glands, such as the thyroid gland, ovaries, and testes. Hormonal signaling involves the following steps: # Biosynthesis of a particular hormone in a particular tissue. # Storage and secretion of the hormone. # Transport of the hormone to the target cell(s). # Recogniti...
1
Gene expression + Signal Transduction
A salamander (or deadman's foot or furnace bear) in the metallurgy dialect means all liquid and solidified materials in the hearth of a blast furnace below the tap hole. The target of the salamander tapping is to remove the remaining hot metal and slag from the blast furnace to allow a safe and efficient intermediate r...
0
Metallurgy
The method is similar to the cyanide method above, except sulfuric acid is used to dissolve copper from its ores. The acid is recycled from the solvent extraction circuit (see solvent extraction-electrowinning, SX/EW) and reused on the leach pad. A byproduct is iron(II) sulfate, jarosite, which is produced as a byprodu...
0
Metallurgy
A similar-looking kind of damage is called false brinelling and is caused by fretting wear. Fretting wear occurs when localized wear-marks develop in evenly spaced patterns, with raised or unworn portions in between, like frets on a guitar. False brinelling occurs in two types: stationary and by precession. Stationary...
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Metallurgy
Hazardous materials are often carried in pipelines and thus their structural integrity is of paramount importance. Corrosion of a pipeline can thus have grave consequences. One of the methods used to control pipeline corrosion is by the use of Fusion bonded epoxy coatings. DCVG is used to monitor it. Impressed current...
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Metallurgy
*Monocytes / macrophages: the key chemokines that attract these cells to the site of inflammation include: CCL2, CCL3, CCL5, CCL7, CCL8, CCL13, CCL17 and CCL22. *T-lymphocytes: the four key chemokines that are involved in the recruitment of T lymphocytes to the site of inflammation are: CCL2, CCL1, CCL22 and CCL17. Fur...
1
Gene expression + Signal Transduction
PGC-1α is thought to be a master integrator of external signals. It is known to be activated by a host of factors, including: # Reactive oxygen species and reactive nitrogen species, both formed endogenously in the cell as by-products of metabolism but upregulated during times of cellular stress. #Fasting can also incr...
1
Gene expression + Signal Transduction
In orthodox two-component signaling, a histidine kinase protein autophosphorylates on a histidine residue in response to an extracellular signal, and the phosphoryl group is subsequently transferred to an aspartate residue on the receiver domain of a response regulator. In phosphorelays, the "hybrid" histidine kinase c...
1
Gene expression + Signal Transduction
Bacterial initiation factor-2 is a bacterial initiation factor. IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNA binds to the IF2 then IF2 transfers the tRNA into the partial P site. When the 5...
1
Gene expression + Signal Transduction
The proper identification of splice sites has to be highly precise as the consensus splice sequences are very short and there are many other sequences similar to the authentic splice sites within gene sequences, which are known as cryptic, non-canonical, or pseudo splice sites. When an authentic or real splice site is ...
1
Gene expression + Signal Transduction
Homologous recombination is the exchange of genes between two DNA strands that include extensive regions of base sequences that are identical to one another. In eukaryotic species, bacteria, and some viruses, homologous recombination happens spontaneously and is a useful tool in genetically engineered. Homologous recom...
1
Gene expression + Signal Transduction
Fulmer Research Institute was founded in 1945 as a UK contract research and development organization specializing in materials technology and related areas of physics and chemistry. It was modelled on American contract research companies such as Battelle Memorial Institute and The Mellon Institute of Industrial Resear...
0
Metallurgy
Hellmut Friedrich Fischmeister (14 May 1927 – 6 November 2019) was an Austrian metallurgist who was a pioneer in powder metallurgy.
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Metallurgy
In resting cells, axin molecules oligomerize with each other through their C-terminal DIX domains, which have two binding interfaces. Thus they can build linear oligomers or even polymers inside the cytoplasm of cells. DIX domains are unique: the only other proteins known to have a DIX domain are Dishevelled and DIXDC1...
1
Gene expression + Signal Transduction
* Bacteriophytochrome * sensory bacteriorhodopsin * Halorhodopsin * Proteorhodopsin * Cyanobacteriochrome
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Gene expression + Signal Transduction
Galaxy IV was a telecommunications satellite that was disabled and lost due to short circuits caused by tin whiskers in 1998. It was initially thought that space weather contributed to the failure, but later it was discovered that a conformal coating had been misapplied, allowing whiskers formed in the pure tin plating...
0
Metallurgy
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Antagonist drugs interfere in the natural operation of receptor proteins. They are sometimes called blockers; examples include alpha b...
1
Gene expression + Signal Transduction
A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell. GRN also play a central role in morphogenesis, the creati...
1
Gene expression + Signal Transduction
A second major group of British bun ingots date to the Roman period and are found mostly in the copper-rich highland areas of Wales and in Scotland. They are heavier than the LBA examples, with weights ranging between 12 and 22 kg. Some have stamps clearly dating them to the Roman period including an example that reads...
0
Metallurgy
In a cascade mediated by a GPCR known as β adrenoceptor, activated by catecholamines (notably norepinephrine), PKA gets activated and phosphorylates numerous targets, namely: L-type calcium channels, phospholamban, troponin I, myosin binding protein C, and potassium channels. This increases inotropy as well as lusitrop...
1
Gene expression + Signal Transduction
The idea that there must be specific transport proteins associated with the uptake of monoamines and acetylcholine into vesicles developed due to the discovery of specific inhibitors which interfered with monoamine neurotransmission and also depleted monoamines in neuroendocrine tissues. VMAT1 and VMAT2 were first ide...
1
Gene expression + Signal Transduction
An important disadvantage of polycrystalline NiAl-based alloys are their room-temperature and high-temperature brittleness, which interferes with potential structural applications. This brittleness is generally attributed to the inability of dislocations to move in the highly ordered lattices. The introduction of small...
0
Metallurgy
Copper goes through a natural oxidation process that forms a unique protective patina on the metal. The surface of the metal undergoes a series of color changes: from iridescent/salmon pinks to oranges and reds interspersed with brassy yellows, blues, greens and purples. As the oxide thickens, these colors are replaced...
0
Metallurgy
Complex metallic alloys (CMAs) or complex intermetallics (CIMs) are intermetallic compounds characterized by the following structural features: #large unit cells, comprising some tens up to thousands of atoms, #the presence of well-defined atom clusters, frequently of icosahedral point group symmetry, #the occurrence ...
0
Metallurgy
A well studied pioneer factor family is the Groucho-related (Gro/TLE/Grg) transcription factors that often have a negative effect on transcription. These chromatin binding domains can span up to 3-4 nucleosomes. These large domains are scaffolds for further protein interactions and also modify the chromatin for other...
1
Gene expression + Signal Transduction
A15 phases are intermetallic alloys with an average coordination number (ACN) of 13.5 and eight AB stoichiometry atoms per unit cell where two B atoms are surrounded by CN12 polyhedral (icosahedra), and six A atoms are surrounded by CN14 polyhedral. NbGe is a superconductor with A15 structure.
0
Metallurgy
The first event appears to be the accumulation of cell adhesion molecules such as NF186 or NrCAM. The intra-cellular regions of these cell-adhesion molecules interact with ankyrin G, which serves as an anchor for sodium channels. At the same time, the periaxonal extension of the glial cell wraps around the axon, givi...
1
Gene expression + Signal Transduction
Inflammation is the bodys response to foreign objects, irritants, germs, and even pathogens. Although such a response is standard in some cases, if left untreated, chronic inflammation can lead to muscle degeneration, gastrointestinal disorders, and some types of cancers. While most treatments, such as anti-inflammator...
1
Gene expression + Signal Transduction
Fixed aRME are established either by silencing of one allele that previously has been biallelically expressed, or by activation of a single allele from previously silent gene. Expression activation of the silent allele is coupled with a feedback mechanism that prevents expression of the second allele. Another scenario ...
1
Gene expression + Signal Transduction
Blast furnaces operate on the principle of chemical reduction whereby carbon monoxide converts iron oxides to elemental iron. Blast furnaces differ from bloomeries and reverberatory furnaces in that in a blast furnace, flue gas is in direct contact with the ore and iron, allowing carbon monoxide to diffuse into the or...
0
Metallurgy
The Scenedesmus obliquus mitochondrial code (translation table 22) is a genetic code found in the mitochondria of Scenedesmus obliquus, a species of green algae.
1
Gene expression + Signal Transduction
Sintering in practice is the control of both densification and grain growth. Densification is the act of reducing porosity in a sample, thereby making it denser. Grain growth is the process of grain boundary motion and Ostwald ripening to increase the average grain size. Many properties (mechanical strength, electrical...
0
Metallurgy
Survivin is shown to be clearly regulated by the cell cycle, as its expression is found to be dominant only in the G2/M phase. This regulation exists at the transcriptional level, as there is evidence of the presence of cell-cycle-dependent element/cell-cycle gene homology region (CDE/CHR)boxes located in the survivin ...
1
Gene expression + Signal Transduction
RoXaN is capable of interacting with NSP3 in vivo and during rotavirus infection. Domains of interaction correspond to the dimerization domain of NSP3 (amino acids 163 to 237) and the LD domain of RoXaN (amino acids 244 to 341). The interaction between NSP3 and RoXaN does not impair the interaction between NSP3 and eIF...
1
Gene expression + Signal Transduction
The thermal effective mass of electrons in a metal is the apparent mass due to interactions with the periodic potential of the crystal lattice, with phonons (e.g. phonon drag), and interaction with other electrons. The resulting effective mass of electrons contributes to the electronic heat capacity of the metal, leadi...
0
Metallurgy
In general, the most important requisite is to calibrate the incubation time of the assay both to the model cell and the ligand to be evaluated. Too short incubation time results in no cells in the sample, while too long time perturbs the concentration gradients and measures more chemokinetic than chemotactic responses...
1
Gene expression + Signal Transduction
An action potential is a spike of both positive and negative ionic discharge that travels along the membrane of a cell. The creation and conduction of action potentials represents a fundamental means of communication in the nervous system. Action potentials represent rapid reversals in voltage across the plasma membr...
1
Gene expression + Signal Transduction
Both sexual and asexual reproductions are implemented. Asexual reproduction is implemented as producing the offsprings genome (the gene network) by directly copying the parents genome. Sexual reproduction is implemented as the recombination of the two parents' genomes.
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Gene expression + Signal Transduction
*Agricola, Georgius, 1556, Translation Hoover, Herbert, 1912, De re metallica, [http://farlang.com/books/agricola-hoover-de-re-metallica Farlang, full streaming version + scientific introduction] *Craddock, P. T., 1989. Metalworking Techniques. In: Youngs, S. (ed), Work of Angels: Masterpieces of Celtic Metalwork, 6th-...
0
Metallurgy
In order for paracrine factors to successfully induce a response in the receiving cell, that cell must have the appropriate receptors available on the cell membrane to receive the signals, also known as being competent. Additionally, the responding cell must also have the ability to be mechanistically induced.
1
Gene expression + Signal Transduction
Two classes of transcription terminators, Rho-dependent and Rho-independent, have been identified throughout prokaryotic genomes. These widely distributed sequences are responsible for triggering the end of transcription upon normal completion of gene or operon transcription, mediating early termination of transcripts ...
1
Gene expression + Signal Transduction
Genome-wide association studies (GWAS) identify linkages between alleles and observable traits such as phenotypes and diseases. Most of the associations are between single-nucleotide polymorphisms (SNPs) and the trait being examined and most of these SNPs are located in non-functional DNA. The association establishes a...
1
Gene expression + Signal Transduction
The probe to be detected is labeled with some biotin-molecules. After incubation with a gold-coupled anti-biotin conjugate, silver nitrate and a reducing agent are added. The reaction starts whereas the gold particle serves as a starting point for the silver precipitation. The reaction needs to be stopped after a spec...
1
Gene expression + Signal Transduction
In a multiple-hearth roaster, the concentrate drops through a series of 9 or more hearths stacked inside a brick-lined cylindrical column. As the feed concentrate drops through the furnace, it is first dried by the hot gases passing through the hearths and then oxidized to produce calcine. The reactions are slow and ca...
0
Metallurgy
Highly repetitive DNA consists of short stretches of DNA that are repeated many times in tandem (one after the other). The repeat segments are usually between 2 bp and 10 bp but longer ones are known. Highly repetitive DNA is rare in prokaryotes but common in eukaryotes, especially those with large genomes. It is somet...
1
Gene expression + Signal Transduction
Mono(ADP-ribosyl)transferases commonly catalyze the addition of ADP-ribose to arginine side chains using a highly conserved R-S-EXE motif of the enzyme. The reaction proceeds by breaking the bond between nicotinamide and ribose to form an oxonium ion. Next, the arginine side chain of the target protein then acts a nucl...
1
Gene expression + Signal Transduction
Most ceramics are extremely hard and must be wet-sawed with a circular blade embedded with diamond particles. A metallography or lapidary saw equipped with a low-density diamond blade is usually suitable. The blade must be cooled by a continuous liquid spray.
0
Metallurgy
Spt-Ada-Gcn5 acetyltransferase (SAGA) is a histone modifying transcriptional co-activator that is composed of 21 proteins and exhibits histone acetyltransferase (HAT) and deubiquitinating (DUB) activity. In yeast the SAGA complex serves to activate the transcription of approximately 10% of the genome, and this active g...
1
Gene expression + Signal Transduction
In order for proper gene expression to occur, transcription must stop at specific sites. Two termination mechanisms are well known: *Intrinsic termination (also called Rho-independent termination): Specific DNA nucleotide sequences signal the RNA polymerase to stop. The sequence is commonly a palindromic sequence that ...
1
Gene expression + Signal Transduction
Many countries, including India, France and Germany, have underground deposits of iron ore in dust form (blue dust). Such iron ore cannot be directly charged in a blast furnace. In the early 20th century, sinter technology was developed for converting ore fines into lumpy material chargeable in blast furnaces. Sinter t...
0
Metallurgy
Until the early 19th century, the usual method of producing wrought iron involved a charcoal-fired finery in a finery forge. In the beginning of the 19th century this became an obsolete process and was slowly replaced by the coal-fueled puddling process. However, charcoal continued to be used in some forges after mos...
0
Metallurgy
This form of corrosion occurs principally in metal alloys. The less noble metal of the alloy, is selectively leached from the alloy. Removal of zinc from brass is a more common example.
0
Metallurgy
PHLPP is a member of the PPM family of phosphatases, which requires magnesium or manganese for their activity and are insensitive to most common phosphatase inhibitors, including [okadaic acid]. PHLPP1 and PHLPP2 have a similar domain structure, which includes a putative Ras association domain, a pleckstrin homology d...
1
Gene expression + Signal Transduction
Capping is a three-step process that utilizes the enzymes RNA triphosphatase, guanylyltransferase, and methyltransferase. Through a series of three steps, the cap is added to the first nucleotides 5 hydroxyl group of the growing mRNA strand while transcription is still occurring. First, RNA 5 triphosphatase hydrolyze...
1
Gene expression + Signal Transduction
Reciprocal silencing on the tissue level refers to the same pattern of silencing and expression of homeologous loci. However, in this case, the differences in silencing and expression occur between two types of tissue within the same individual, rather than in individuals of different populations. This is an example of...
1
Gene expression + Signal Transduction
Interferome offers many ways of searching and retrieving data from the database: *Identify interferon regulated gene signatures in microarray data; *Gene Ontology analysis and annotation; *Normal tissue expression of interferon regulated genes; *Regulatory analysis of interferon regulated genes; *BLAST (Basic Local Ali...
1
Gene expression + Signal Transduction