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Evaluated were 860 patients with ACS from January through December, 2003.
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Describing what other writers do in their published work
832,264
We evaluated baseline characteristics, ACS mode of presentation, medication during hospital stay, indication for clinical treatment or myocardial revascularization MR and inhospital mortality.
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Referring to another writer’s idea(s) or position
754,360.9375
Five hundred and three 58.3 were male, mean age 62.6 years 11.9.
W1973979946
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Reporting positive and negative reactions
763,788.9375
Seventyeight 9.1 were discharged with the diagnosis of acute STelevation myocardial infarction STEMI, 238 27.7 with nonSTelevation myocardial infarction nonSTEMI, 516 60 with unstable angina UA, two 0.2 with atypical manifestations of ACS and 26 3 with noncardiac chest pain.
W1973979946
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Describing the process: expressing purpose with for
759,115.0625
During hospitalization, 87.9 of patients were given a betablocker, 95.9 acetylsalicylic acid, 89.9 antithrombin therapy, 86.2 intravenous nitroglycerin, 6.4 glycoprotein GP IIbIIIa receptor inhibitor, 35.9 clopidogrel, 77.9 angiotensinconverting enzyme inhibitor, and 70,9 statin drugs.
W1973979946
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Reference to previous research: important studies
777,348.9375
Coronary arteriography was performed in 72 patients 92.3 with STEMI, and in 452 59.8 with nonSTEMI ACS p 0.0001.
W1973979946
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Contrasting sources with ‘however’ for emphasis
655,066
Myocardial revascularization MR surgery was indicated for 12.9 and percutaneous coronary intervention for 26.6.
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Contrasting sources with ‘however’ for emphasis
693,230
Inhospital mortality was 4.8, and no difference was recorded between the proportion of deaths among patients with STEMI and nonSTEMI ACS 6.4 versus 4.8 p 0.578.
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Synthesising sources: contrasting evidence or ideas
760,194
In this registry, we provide a description of ACS patient, which allows the evaluation of the demographic characteristics, medical treatment prescribed, and inhospital mortality.
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Surveys and interviews: Reporting response rates
714,843.0625
A greater awareness of our reality may help the medical community to adhere more strictly to the procedures set by guidelines.
W1973979946
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Referring to the literature to justify a method or approach
667,212
ABSTRACT We present an unusual tumorous variety of scleromyxedema mimicking facies leonina in lymphoma.
W2005484752
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Stating the purpose of the thesis, dissertation, or research article (note use of present tense)
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In spite of pronounced and widespread cutaneous changes, hypergammaglobulinaemia and paraproteinaemia, the general condition of the patient was satisfactory, there was no internal involvement and no symptoms of any malignancy.
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Restating a result or one of several results
782,888.9375
Initially, melphalan and corticosteroids were applied but were not effective.
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Referring to another writer’s idea(s) or position
923,776
Highdose intravenous immunoglobulin IVIG therapy had dramatic effect, and after five 5day monthly courses the tumours almost regressed and the skin became less hard.
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Identifying a controversy within the field of study
683,664
After a further five courses in the following year there was complete clearance, which was sustained without any therapy for 1 year until now.
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Making recommendations for further research work
609,601
IVIG appears to be the therapy of choice for scleromyxedema.
W2005484752
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Establishing the importance of the topic for the world or society: time frame given
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We stress, however, that at the start of therapy, IVIG applications should be supplemented with small doses of melphalan andor corticosteroids.
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Noting the lack of or paucity of previous research
728,210
Chemischer InformationsdienstVolume 16, Issue 3 Preparative Organic Chemistry ChemInform Abstract PHOTOCHEMISTRY OF NAROYLANTHRANILIC ACIDS T. NAITO, T. NAITOSearch for more papers by this authorI.
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Referring to another writer’s idea(s) or position
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NINOMIYA, I. NINOMIYASearch for more papers by this author T. NAITO, T. NAITOSearch for more papers by this authorI.
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Describing the process: sequence words
726,752
NINOMIYA, I. NINOMIYASearch for more papers by this author First published January 22, 1985 httpsdoi.org10.1002chin.198503114Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare fulltext accessPlease review our Terms and Condit...
W2016608693
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Referring to secondary sources
711,824
I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a fulltext version of this article with your friends and colleagues.
W2016608693
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Stating what is currently known about the topic
629,298
Learn more.
W2016608693
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Transition: moving to the next result
723,904
Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.
W2016608693
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Explaining keywords (also refer to Defining Terms)
664,184
Volume16, Issue3January 22, 1985 RelatedInformation
W2016608693
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Giving reasons why a particular method was rejected
793,112.9375
An automated recognition technique was proposed for providing information on such as the skeleton of thoracic aorta, diameter of each crosssection along the skeleton, curvature of it and position of the aneurysm on the aorta using multislice CT images.
W1581785689
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Establising the importance of the topic as a problem to be addressed
701,272
The information was indispensable to design a stent with perfect fitting to the patients aorta aneurysm region so that the stent kept the original position against the blood stream.
W1581785689
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Establishing the importance of the topic for the discipline
660,603
The proposed technique was based on the fact that crosssections of the aorta aneurysm region had deformation from circular shape while those of the normal region had circular shape due to blood pressure.
W1581785689
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Describing the limitations of the current study
627,939
The threedimensional shape of the aorta was extracted by applying an algorithm Successive Region Growing.
W1581785689
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Outlining the structure of a short paper
711,587.0625
Cylinder model fitting well reduced noise and enabled us to detect the deformation with high accuracy.
W1581785689
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Explaining the significance of the findings or contribution of the study
766,866
Skeleton and diameter of the aorta were obtained from the resultant fitting circle.
W1581785689
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Outlining the structure of a short paper
677,342
The proposed technique was successfully applied to actual 90 slice of patient multislice CT data.
W1581785689
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Previous research: area investigated as the sentence subject
721,332
Pseudomonas aeruginosa biofilm formation was increased by addition of sucrose to LuriaBertani medium, whereas addition of NaCl to a final similar osmolarity and use of maltose instead of sucrose, were ineffective.
W2123797961
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Explaining the provenance of articles for review
605,635
In a previous study, we showed that the extracytoplasmic sigma factor SigX is activated in the presence of sucrose.
W2123797961
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[ { "m": "Transition: moving to the next result", "s": 740882 }, { "m": "Describing the limitations of the current study", "s": 747350 }, { "m": "Introducing the limitations of the current study", "s": 755756.9375 }, { "m": "Identifying a controversy within the field of study",...
Giving reasons for personal interest in the research (sometimes found in the humanities, and the applied human sciences)
709,107.0625
The sucrosemediated pellicle increase was abolished in a sigX mutant strain.
W2123797961
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Reporting positive and negative reactions
703,700.9375
Sucrose addition led to an increase in pel expression and cyclicdiguanylate cdiGMP pool level production.
W2123797961
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Transition: moving to the next result
715,424
Interestingly, these two phenotypes were strongly decreased in a sigX mutant.
W2123797961
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[ { "m": "Referring to a single investigation in the past: researcher prominent", "s": 794094 }, { "m": "Referring to another writer’s idea(s) or position", "s": 808283.0625 }, { "m": "General comments on the relevant literature", "s": 809758 }, { "m": "Highlighting interesting...
Referring to a single investigation in the past: investigation prominent
779,622
Since pel is not known as a SigXtarget, we suspect SigX to be involved in the cdiGMP production.
W2123797961
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[ { "m": "Identifying a knowledge gap in the field of study", "s": 793400.9375 }, { "m": "Transition: moving to the next result", "s": 807319.0625 }, { "m": "Synthesising sources: supporting evidence or ideas", "s": 808852 }, { "m": "Summarising the literature review", "s":...
Providing background information: reference to the literature
778,590
We found that expression of the diguanylate cyclase PA4843 gene was increased in the presence of sucrose at least partly through SigX activity.
W2123797961
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Identifying a controversy within the field of study
674,294
Our study shows that sucrose itself rather than osmolarity favours the biofilm mode of P. aeruginosa through the activation of SigX.
W2123797961
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[ { "m": "Describing the characteristics of the participants", "s": 741784 }, { "m": "Stating purpose of the current research with reference to gaps or issues in the literature", "s": 802070 }, { "m": "Explaining the significance of the current study", "s": 803334 }, { "m": "No...
Explaining the significance of the findings or contribution of the study
711,054
In Shakespeares drama Mikebai he reflected the new social evil of the Renaissance times by revising early chronicle.
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Providing background information: reference to the purpose of the study
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The peculiar individual psychology trait of Mikebai was deeply and carefully depicted.
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[ { "m": "Giving reasons for personal interest in the research (sometimes found in the humanities, and the applied human sciences)", "s": 802160 }, { "m": "Reporting positive and negative reactions", "s": 858120.9375 }, { "m": "Referring to another writer’s idea(s) or position", "s": 8...
Identifying a knowledge gap in the field of study
715,391.0625
The fight between goodness and badness of characters and fierce conflict of justice and evil was showed.
W2349757815
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[ { "m": "Explaining the provenance of articles for review", "s": 641536 }, { "m": "Describing the process: using + instrument", "s": 736851.0625 }, { "m": "Explaining the provenance of the participants", "s": 753654 }, { "m": "Describing the characteristics of the participants...
Giving reasons for personal interest in the research (sometimes found in the humanities, and the applied human sciences)
629,936
The inevitable tragedy destiny and essence was revealed.
W2349757815
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[ { "m": "Indicating an unexpected outcome", "s": 724550 }, { "m": "Describing the process: expressing purpose with for", "s": 732203.0625 }, { "m": "Establishing the importance of the topic for the discipline", "s": 779644.9375 }, { "m": "Referring to secondary sources", "...
Offering an explanation for the findings
722,108
The transformation was sucessfully finished.
W2349757815
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[ { "m": "Synthesising sources: contrasting evidence or ideas", "s": 707390 }, { "m": "Transition: moving to the next result", "s": 734804.9375 }, { "m": "Stating the purpose of the thesis, dissertation, or research article (note use of present tense)", "s": 758760 }, { "m": "C...
Synthesising sources: supporting evidence or ideas
685,732
This article presents the analysis of the Implementation Program of Multifunctional Resources Room, addressing modes of constitution of this policy and data about the enrollment of students with disabilities and offering of the Specialized Educational Service in Rio Grande do Sul.
W1525146318
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[ { "m": "Introducing the limitations of the current study", "s": 649085 }, { "m": "Explaining the significance of the current study", "s": 666736 }, { "m": "Describing the characteristics of the participants", "s": 667328 }, { "m": "Stating the aims of the current research (no...
Describing the limitations of the current study
615,132
The methodology was based on reading of the normative documents, of theoretical and methodological referential of analysis and evaluation of public policies and setting up school census data of 2009, 2010 and 2011, which show a significant increase in enrollment of students in SES and in the public school system of the...
W1525146318
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[ { "m": "Explaining the significance of the current study", "s": 664671 }, { "m": "Describing the process: typical verbs in the passive form", "s": 666436 }, { "m": "Stating purpose of the current research with reference to gaps or issues in the literature", "s": 673736.9375 }, { ...
Establishing the importance of the topic for the discipline
643,246
Private forprofit institutions have been the fastest growing part of the U.S. higher education sector.
W1512056244
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[ { "m": "Giving reasons for personal interest in the research (sometimes found in the humanities, and the applied human sciences)", "s": 729196.9375 }, { "m": "Transition: moving to the next result", "s": 729818 }, { "m": "Reporting positive and negative reactions", "s": 762330 }, ...
Identifying a controversy within the field of study
663,005
Forprofit enrollment increased from 0.2 percent to 9.1 percent of total enrollment in degreegranting schools from 1970 to 2009, and forprofit institutions account for the majority of enrollments in nondegree granting postsecondary schools.
W1512056244
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[ { "m": "Stating the purpose of the thesis, dissertation, or research article (note use of present tense)", "s": 753723.0625 }, { "m": "Describing the process: typical verbs in the passive form", "s": 757300.9375 }, { "m": "Describing what other writers do in their published work", "s...
Transition: moving to the next result
717,392
We describe the schools, students, and programs in the forprofit higher education sector, its phenomenal recent growth, and its relationship to the federal and state governments.
W1512056244
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[ { "m": "Offering an explanation for the findings", "s": 603024 }, { "m": "Describing the process: expressing purpose with for", "s": 627067 }, { "m": "Identifying a knowledge gap in the field of study", "s": 650854 }, { "m": "Describing the research design and the methods use...
Giving reasons for personal interest in the research (sometimes found in the humanities, and the applied human sciences)
541,287
Using the 2004 to 2009 Beginning Postsecondary Students BPS longitudinal survey, we assess outcomes of a recent cohort of firsttime undergraduates who attended forprofits relative to comparable students who attended community colleges or other public or private nonprofit institutions.
W1512056244
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[ { "m": "Identifying a controversy within the field of study", "s": 663759 }, { "m": "Referring back to the purpose of the paper or study", "s": 674391.0625 }, { "m": "Identifying a knowledge gap in the field of study", "s": 687492 }, { "m": "Establishing the importance of the...
Giving reasons for personal interest in the research (sometimes found in the humanities, and the applied human sciences)
644,187
We find that relative to these other institutions, forprofits educate a larger fraction of minority, disadvantaged, and older students, and they have greater success at retaining students in their first year and getting them to complete short programs at the certificate and AA levels.
W1512056244
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[ { "m": "Reporting positive and negative reactions", "s": 748583.0625 }, { "m": "Identifying a knowledge gap in the field of study", "s": 841080.9375 }, { "m": "Establishing the importance of the topic for the world or society: time frame given", "s": 892878 }, { "m": "Describ...
Identifying a controversy within the field of study
730,382
But we also find that forprofit students end up with higher unemployment and idleness rates and lower earnings six years after entering programs than do comparable students from other schools, and that they have far greater student debt burdens and default rates on their student loans.
W1512056244
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[ { "m": "Identifying a knowledge gap in the field of study", "s": 663032 }, { "m": "Previous research: What has been established or proposed", "s": 671476.9375 }, { "m": "Highlighting inadequacies or weaknesses of previous studies (also refer to Being Critical)", "s": 677271.0625 },...
Transition: moving to the next result
631,008
The mammalian Target of Rapamycin mTOR nutrientsensing pathway plays a fundamental role in cell growth, and proliferation, as well as in tumor metabolism.
W2236282264
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[ { "m": "Contrasting sources with ‘however’ for emphasis", "s": 705192.9375 }, { "m": "Noting the lack of or paucity of previous research", "s": 708270 }, { "m": "Previous research: area investigated as the sentence subject", "s": 730900 }, { "m": "Offering an explanation for ...
Transition: moving to the next result
705,035.0625
mTOR is the catalytic subunit that nucleates two functionally and structurally distinct complexes namely mTORC1 mammalian Target of Rapamycin Complex 1 and mTORC2 mammalian Target of Rapamycin Complex 2.
W2236282264
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[ { "m": "Previous research: area investigated as the sentence subject", "s": 717767.0625 }, { "m": "Transition: moving to the next result", "s": 766580 }, { "m": "Surveys and interviews: Reporting participants’ views", "s": 771703.0625 }, { "m": "Describing the process: statis...
Contrasting sources with ‘however’ for emphasis
689,504
mTORC1 integrates inputs from nutrients, growth factors, and environmental cues and transduces signals to downstream targets to promote anabolism and decrease catabolism.
W2236282264
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[ { "m": "Stating the focus, aim, or argument of a short paper", "s": 743500.9375 }, { "m": "Summarising the literature review", "s": 744756.9375 }, { "m": "Contrasting sources with ‘however’ for emphasis", "s": 751103.0625 }, { "m": "Synthesising sources: supporting evidence o...
Summarising the studies reviewed
742,384
As such, mTORC1 is considered a master regulator of metabolism, cell growth, and proliferation.
W2236282264
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[ { "m": "Referring to previous work to establish what is already known", "s": 751802 }, { "m": "Referring to a single investigation in the past: investigation prominent", "s": 762488.9375 }, { "m": "Previous research: area investigated as the sentence subject", "s": 764348 }, { ...
Transition: moving to the next result
750,707.0625
mTORC1 is activated by PI3K phosphoinositide 3kinasesAktPKB protein kinase B and Ras ERK extracellular signalregulated kinase pathways, both of which are the most common oncogenic signaling pathways activated in cancer.
W2236282264
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[ { "m": "Transition: moving to the next result", "s": 690810 }, { "m": "Contrasting sources with ‘however’ for emphasis", "s": 760928 }, { "m": "Explaining keywords (also refer to Defining Terms)", "s": 798704.9375 }, { "m": "Highlighting inadequacies or weaknesses of previous...
Identifying a knowledge gap in the field of study
678,572
Recently, mTORC2 emerged as an important contributor to cellular and tumormetabolism.
W2236282264
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[ { "m": "Explaining the significance of the findings or contribution of the study", "s": 704582 }, { "m": "Describing the process: typical verbs in the passive form", "s": 753407.0625 }, { "m": "Stating the aims of the current research (note frequent use of past tense)", "s": 756383.0...
Identifying a knowledge gap in the field of study
673,710
mTORC2 receives inputs mainly from growth factors and regulates the organization of actin cytoskeleton, cell survival, and cellular metabolism.
W2236282264
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[ { "m": "Identifying a knowledge gap in the field of study", "s": 725210 }, { "m": "Identifying a controversy within the field of study", "s": 751736.9375 }, { "m": "Contrasting sources with ‘however’ for emphasis", "s": 774270 }, { "m": "Commenting on the strengths of the cur...
Explaining the provenance of articles for review
713,936.9375
This review focuses on the role of mTORC2 in cellular metabolism and cancer metabolism.
W2236282264
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[ { "m": "Noting the lack of or paucity of previous research", "s": 647588 }, { "m": "Comparing the result: supporting previous findings", "s": 649064 }, { "m": "General comments on the relevant literature", "s": 654149 }, { "m": "Explaining the significance of the findings or ...
Advising cautious interpretation of the findings
588,916
Understanding the underpinning of mTORC2 signaling and targeting both mTORC1 and mTORC2 complexes, holds promise for regimens in cancer early detection, monitoring, and treatment.
W2236282264
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[ { "m": "Referring to important texts in the area of interest", "s": 733872 }, { "m": "Establishing the importance of the topic for the discipline: time frame given", "s": 744400 }, { "m": "Identifying a controversy within the field of study", "s": 755732.9375 }, { "m": "Contr...
Identifying a knowledge gap in the field of study
694,018
BautechnikVolume 80, Issue 12 p. 932932 Termine Österreichischer Betontag 2004 First published 02 April 2013 httpsdoi.org10.1002bate.200306350AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare fulltext accessPlease review our Terms and Conditi...
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Referring to secondary sources
683,664.9375
I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a fulltext version of this article with your friends and colleagues.
W4240097692
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Stating what is currently known about the topic
629,298
Learn more.
W4240097692
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Transition: moving to the next result
723,904
Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.
W4240097692
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[ { "m": "Describing what other writers do in their published work", "s": 769868 }, { "m": "Describing the process: expressing purpose with for", "s": 786952 }, { "m": "Identifying a controversy within the field of study", "s": 790296 }, { "m": "Referring to data in a table or ...
Explaining keywords (also refer to Defining Terms)
664,184
Volume80, Issue12December 2003Pages 932932 RelatedInformation
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Referring to another writer’s idea(s) or position
744,872
Tea culture,which has a long history,has close relationship with tourism.
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Giving reasons why a particular method was rejected
774,720
The study aimed to discuss the important approaches and main manifestation of the inheriting and promotion of tea culture by tourism,and put forward several measures for better utilizing tourism industry to promote the development of tea culture in China
W1414027971
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Surveys and interviews: Reporting participants’ views
591,929
The desire of knowledge, one of mans most important goals, there are also mixed wishes of other type, like ambition or competition, which can deviate him from his uninterested objectives.
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Identifying a controversy within the field of study
579,916
That is why there are many people who throw a suspect on this libido sciendi that has become a libido dominandi where the legal valorization of power and the idolatry of progress are combined.
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Describing the process: statistical procedures
733,936.9375
It will be the ethic comisions or comites to play a calming function that can work as a boundary to this cultural anguish.
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Establishing the importance of the topic for the world or society
781,420
However, these possible deviations must not only be atributed to the desire of knowing in itself, but to the social system, which, troughout the institutions, compels investigators to compete among themselves with projects and publications, and obliges them to enter either into an economic competition or into an intern...
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[ { "m": "Referring to a single investigation in the past: investigation prominent", "s": 755254 }, { "m": "Giving reasons for personal interest in the research (sometimes found in the humanities, and the applied human sciences)", "s": 758464.9375 }, { "m": "Transition: moving to the next ...
Reporting positive and negative reactions
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As members of a scientific comunity, with its own interests, it is necessary for us to defend the autonomy of this libido cognoscendi in front of those who take social decisions, in the measure that economical resources for investigation depend on them.
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Identifying a controversy within the field of study
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Uninterested investigation is still very important for the cultural wellfare of society, but it is important to be on guard, as man is not only in the centre of investigations, but also of its applications.
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Giving reasons for personal interest in the research (sometimes found in the humanities, and the applied human sciences)
615,982
We address the task of targeted sentiment as a means of understanding the sentiment that students hold toward courses and instructors, as expressed by students in their comments.
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Explaining the significance of the current study
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We introduce a new dataset consisting of student comments annotated for targeted sentiment and describe a system that can both identify the courses and instructors mentioned in student comments, as well as label the students sentiment toward those entities.
W2572212662
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[ { "m": "Explaining the significance of the current study", "s": 751426 }, { "m": "Explaining the significance of the findings or contribution of the study", "s": 778524 }, { "m": "Referring to important texts in the area of interest", "s": 803254 }, { "m": "Identifying a know...
Explaining keywords (also refer to Defining Terms)
746,639.0625
Through several comparative evaluations, we show that our system outperforms previous work on a similar task.
W2572212662
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Giving reasons why a particular method was rejected
816,454
Excore neutron detector noise has been utilized to monitor core support barrel CSB vibrations.
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[ { "m": "Identifying a knowledge gap in the field of study", "s": 690956.9375 }, { "m": "Surveys and interviews: Reporting participants’ views", "s": 724470 }, { "m": "Giving reasons for personal interest in the research (sometimes found in the humanities, and the applied human sciences)"...
Identifying a controversy within the field of study
671,310
In order to observe longterm changes, noise signals at Sequoyah1 were monitored continuously during the whole first fuel cycle and part of the second cycle.
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Identifying a controversy within the field of study
586,760
Results suggest that neutron noise measurements performed infrequently may not provide adequate surveillance of the CSB because it may be difficult to separate noise amplitude changes due solely to CSB motion from changes caused by fuel motion and burnup.
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[ { "m": "Transition: moving to the next result", "s": 848223.0625 }, { "m": "Giving reasons for personal interest in the research (sometimes found in the humanities, and the applied human sciences)", "s": 863386 }, { "m": "Stating the aims of the current research (note frequent use of pas...
Explaining the provenance of articles for review
786,500
DLC
W1483471382
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Establishing the importance of the topic for the world or society: time frame given
766,842
The protein arginine deiminases PADs are a family of Ca2dependent enzymes that catalyze the conversion of peptidylarginine to peptidylcitrulline in numerous protein substrates.
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[ { "m": "Surveys and interviews: Reporting participants’ views", "s": 807900 }, { "m": "Advising cautious interpretation of the findings", "s": 827640 }, { "m": "Transition: moving to the next result", "s": 850591.0625 }, { "m": "Suggesting implications for what is already kno...
Reporting positive and negative reactions
714,088.9375
Disruption of normal PAD activity plays a role in the pathogenesis of multiple inflammatory diseases such as rheumatoid arthritis RA, chronic obstructive pulmonary disease, ulcerative colitis, multiple sclerosis, psoriasis, Alzheimers disease, and in various cancers.
W167094391
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[ { "m": "Summarising the literature review", "s": 823447.0625 }, { "m": "Advising cautious interpretation of the findings", "s": 823730 }, { "m": "Surveys and interviews: Introducing excerpts from interview data", "s": 858750 }, { "m": "Surveys and interviews: Reporting partic...
Referring to a single investigation in the past: investigation prominent
817,075.0625
PAD inhibitors described in the literature have been useful chemical tools to study the role of PAD enzymes in inflammatory diseases and cancer biology.
W167094391
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[ { "m": "Describing the process: using + instrument", "s": 602119 }, { "m": "Stating purpose of the current research with reference to gaps or issues in the literature", "s": 666115 }, { "m": "Describing the process: sequence words", "s": 701355.0625 }, { "m": "Referring back ...
Giving reasons for personal interest in the research (sometimes found in the humanities, and the applied human sciences)
507,166
Most published PAD inhibitors are mechanismbased inactivators belonging to the halogenamidine chemotype.
W167094391
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[ { "m": "Referring back to the purpose of the paper or study", "s": 817120.9375 }, { "m": "Referring to data in a table or chart", "s": 882147.0625 }, { "m": "General comments on the relevant literature", "s": 885070 }, { "m": "Referring to a single investigation in the past: ...
Outlining the structure of a short paper
800,138
For emerging targets such as the PADs, it can be difficult to distinguish compoundspecific effects from those truly resulting from enzyme inhibition.
W167094391
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[ { "m": "Establishing the importance of the topic for the discipline", "s": 750748 }, { "m": "Stating what is currently known about the topic", "s": 827286 }, { "m": "Reporting positive and negative reactions", "s": 833491.0625 }, { "m": "Referring to another writer’s idea(s) ...
Explaining the provenance of articles for review
572,224
We therefore initiated a fluorescence polarization activitybased protein profiling fluopolABPP high throughput screening HTS campaign to identify a second PAD inhibitor chemotype.
W167094391
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Synthesising sources: supporting evidence or ideas
797,636
The PAD4 HTS campaign identified the natural product streptonigrin SID 11532976 as an irreversible PAD4specific inhibitor.
W167094391
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Highlighting inadequacies or weaknesses of previous studies (also refer to Being Critical)
791,483.0625
We describe herein the medicinal chemistry optimization of streptonigrin to the pan PAD probe ML325 SID 118043677.
W167094391
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Indicating missing, weak, or contradictory evidence
746,632.9375
ML325 inhibits PAD1, 2, 3, and 4 in vitro with IC50 values of 70 nM, 200 nM 170 nM, and 240 nM respectively.
W167094391
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Explaining the significance of the findings or contribution of the study
709,080.9375
In a kinetic assay of inhibition more appropriate for irreversible inhibitors, ML325 has kinactKI values of 3500, 7300, 1900, and 5300 M1min1 for PAD1, 2, 3 and 4 respectively indicating it has less than 4fold selectivity among the four family members.
W167094391
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[ { "m": "Surveys and interviews: Reporting response rates", "s": 793816.9375 }, { "m": "Describing the process: expressing purpose with for", "s": 801098 }, { "m": "Previous research: highlighting negative outcomes", "s": 852766 }, { "m": "Surveys and interviews: Reporting pro...
Contrasting sources with ‘however’ for emphasis
753,684.9375
Despite its promiscuity within the PAD family, ML325 exhibits high selectivity vs. more than 20 cysteinereactive proteins as assayed by activitybased protein profiling.
W167094391
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[ { "m": "Contrasting sources with ‘however’ for emphasis", "s": 795379.0625 }, { "m": "Transition: moving to the next result", "s": 860759.0625 }, { "m": "Highlighting inadequacies or weaknesses of previous studies (also refer to Being Critical)", "s": 861314 }, { "m": "Sugges...
Previous research: area investigated as the sentence subject
784,268
ML325 was also demonstrated to inhibit all four PAD isozymes irreversibly and to be noncytotoxic to NIH3T3 cells.
W167094391
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[ { "m": "Establishing the importance of the topic for the world or society", "s": 805266 }, { "m": "Transition: moving to the next result", "s": 817240.9375 }, { "m": "Previous research: Approaches taken", "s": 820570 }, { "m": "Referring to another writer’s idea(s) or positio...
Explaining the provenance of articles for review
776,910
The complete properties, characterization, and synthesis of ML325 are detailed in this report.
W167094391
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[ { "m": "Describing the process: statistical procedures", "s": 807294 }, { "m": "Surveys and interviews: Reporting participants’ views", "s": 809772.9375 }, { "m": "Restating a result or one of several results", "s": 816803.0625 }, { "m": "Explaining the significance of the fi...
Transition: moving to the next result
776,064
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W2033573194
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[ { "m": "Describing the process: expressing purpose with for", "s": 680467.0625 }, { "m": "Explaining keywords (also refer to Defining Terms)", "s": 699540.9375 }, { "m": "Providing background information: reference to the purpose of the study", "s": 722636 }, { "m": "Explaini...
Offering an explanation for the findings
673,870
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W2033573194
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[ { "m": "Previous research: Approaches taken", "s": 821683.0625 }, { "m": "Establising the importance of the topic as a problem to be addressed", "s": 838396 }, { "m": "Highlighting inadequacies or weaknesses of previous studies (also refer to Being Critical)", "s": 848983.0625 }, ...
Identifying a knowledge gap in the field of study
798,344
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W2033573194
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Identifying a controversy within the field of study
735,439.0625
Sound localization presents a problem for animals with small heads closely spaced ears and poor highfrequency hearing.
W2030849760
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Reporting positive and negative reactions
711,816
In recent tests of spatial resolving power, several small songbirds i.e., great tit, canary, and zebra finch show rather large minimum audible angles MAA on the order of 1520 deg.
W2030849760
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Offering an explanation for the findings
755,608.9375
These results are expected if conventional binaural time and intensity differences are used.
W2030849760
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Describing the process: sequence words
789,980.9375