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The chimera was potent in inducing both acute and chronic EAMG, though less potent than Torpedo electric organ AChR. | W1968206925 | [
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Wildtype AChBP also induced EAMG but was less potent, and weakness developed slowly without an acute phase. | W1968206925 | [
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AChBP is more closely related in sequence to neuronal α7 AChRs that are also homomeric however, autoimmune responses were induced to muscle AChR, but not to neuronal AChR subtypes. | W1968206925 | [
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The greater accessibility of muscle AChRs to antibodies, compared to neuronal AChRs, may allow muscle AChRs to induce selfsustaining autoimmune responses. | W1968206925 | [
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The human α1 subunit MIR is a potent immunogen for producing pathologically significant autoantibodies. | W1968206925 | [
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Additional epitopes in this region or other parts of the AChR extracellular domain contribute significantly to myasthenogenicity. | W1968206925 | [
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We show that an AChRrelated protein can induce EAMG. | W1968206925 | [
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Thus, in principle, an AChRrelated protein could induce MG. | W1968206925 | [
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AChBP is a watersoluble protein resembling the extracellular domain of AChRs, yet rats that developed EAMG had autoantibodies to AChR cytoplasmic domains. | W1968206925 | [
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We propose that an initial autoimmune response, directed at the MIR on the extracellular surface of muscle AChRs, leads to an autoimmune response sustained by muscle AChRs. | W1968206925 | [
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Autoimmune stimulation sustained by endogenous muscle AChR may be a target for specific immunosuppression. | W1968206925 | [
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... | Highlighting inadequacies or weaknesses of previous studies (also refer to Being Critical) | 697,475.0625 |
By many years, DDT was the pesticide for excellence to fight plagues and vectors of diseases. | W143695098 | [
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Nevertheless, after a series of attacks nonscientists based on the book Silence Spring, DDT was prohibited by the EPA in 1972. | W143695098 | [
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Labeling of the expiants excised on day 13 of gestation revealed that precursors of the hair cells were progressively losing their mitotic capacity in vitro . | W1974358554 | [
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Quantum branching programs quantum binary decision diagrams, respectively are a convenient tool for examining quantum computations using only a logarithmic amount of space. | W1652601522 | [
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The effect of Argatriopeptin III ANP on basal and stimulated angiotensin II, acetylcholine and KCl depolarization arginine vasopressin AVP release was characterized in the intact hypothalamoneurohypophysial explant HNS and in isolated neurointermediate pituitary lobes NIL. | W1973734991 | [
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In initial experiments using 15min incubation periods, ANP 1010 and 109 M slightly inhibited basal AVP release in both NIL and HNS after a delay of at least 15 min. The most effective ANP concentration was 1010 M, and the inhibitory effect on AVP release was more marked in HNS 52 5 of control compared to 29 8 for NIL. | W1973734991 | [
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When the incubation periods were increased to 30 min ANP 1010 and 109 M significantly decreased AIIstimulated 105 M AVP release in a dosedependent manner p less than 0.05 p less than 0.01, respectively. | W1973734991 | [
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The same concentrations of ANP did not significantly depress ACHstimulated 105 M AVP release p less than 0.1 for both concentrations. | W1973734991 | [
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Although the sites of action cannot be absolutely localized to the ventral hypothalamus andor the neurohypophysis, an effect in the hypothalamus seems very likely. | W1973734991 | [
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The article is devoted to the generalization of data on mining of natural resources in Rostov region. | W184884750 | [
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Fields of energy resources coal, fuel oil, gas, condensate, fluxing limestone, refractory clays, molding sand, cement, quartzite, agrimineral raw materials, silicon materials, building materials used in the economy have been reviewed. | W184884750 | [
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Introduction Needle stick and sharp injuries NSSIs are hazardous and are frequently reported injuries among health care workers HCW. | W1838055451 | [
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... | Suggesting general hypotheses | 758,431.0625 |
The objective of the study is to identify the prevalence of needle stick and sharps injuries NSSIs and the rate of underreporting to occupational health services. | W1838055451 | [
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{
"m": "Establising the imp... | Explaining the significance of the findings or contribution of the study | 641,122 |
It also aims to explore the reasons for underreporting and the knowledge, awareness and perception of risk of needle stick injuries in Obstetrics and Gynaecology Department of two teaching hospitals in Malaysia. | W1838055451 | [
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"m": "Giving reasons why a particular method was rejected",
... | Explaining the significance of the findings or contribution of the study | 748,352 |
Methods A crosssectional study of 194 respondents involving all the healthcare workers and students Specialists, Medical Offiers, House offiers, Nurses, Medical assistants, Medical students and nursing students from Obstertrics and Gynaecology wards in two teaching hospitals who are willing to participate were included... | W1838055451 | [
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... | Summarising the results section | 706,675.0625 |
A structured questionnaire was used as the survey instrument. | W1838055451 | [
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"s": 84304... | Describing questionnaire design | 621,807 |
By using statistical analysis, we compared the data of sociodemographics of health workers, injury information, knowledge on risk of needle stick injury and risk perception on needle stick injury. | W1838055451 | [
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] | Explaining the significance of the findings or contribution of the study | 723,979.0625 |
Results Out of 194 respondents, a total of 199.8 respondents sustained needle stick injury. | W1838055451 | [
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"s": 824840
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{
"m": "Advising cautious interpretation of the findi... | Transition: moving to the next result | 739,903.0625 |
The prevalence was highest among medical student, 42.1n8. | W1838055451 | [
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"s": 780744.... | Offering an explanation for the findings | 752,320 |
Among the 19 cases, 36.8 did not report the incident due to perceived low risk of Hepatitis BHuman Immuno defiiency virus infection 42.9, and that it was not important to report the incident 28.6. | W1838055451 | [
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Conclusion There is a fair understanding of Universal Work Precaution among the HWCs in the Department of Obstetrics and Gynaecology in both the hospitals. | W1838055451 | [
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However, there still exist a large gap between their knowledge, attitude and practice of the universal work precaution. | W1838055451 | [
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... | Identifying a knowledge gap in the field of study | 594,002 |
As noted in the study, the highest prevalence of needle stick injury and its underreporting is among medical students. | W1838055451 | [
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Therefore, exposure prevention among the students must be an institutionalconcern, although every student must be aware of their responsibility for this prevention. | W1838055451 | [
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"s... | Explaining the provenance of articles for review | 737,822 |
Completion of three doses of Hepatitis B must be reiterated and HWCs must also be aware of their antibody status. | W1838055451 | [
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Services dominate all advanced economies but service innovations are still an underresearched topic. | W1507092052 | [
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