text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the effects of these organic phosphates on hemoglobin oxidation by hydroxylamine under aerobic conditions were elucidated by the two state models of hemoglobin including the r and the t state , however , the opposite effects under anaerobic conditions can not be explained without the assumption of the existence of a third conformation of hemoglobin . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
43,
53
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
331,
332
]
} |
amino acid analysis of the enzyme and its photoinactivated derivative shows that photoinactivation is accompanied by loss of nearly 1 residue of aspartic acid/polypeptide chain and an increase in nearly 1 residue of alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
216,
223
]
} |
the mitochondrial dna of the protozoan leishmania tarentolae , known as kinetoplast dna , contains thousands of minicircles linked in a two-dimensional network . | NA | {
"id": "C0012929",
"name": "mitochondrial dna",
"pos": [
4,
21
]
} | {
"id": "C0064360",
"name": "kinetoplast dna",
"pos": [
72,
87
]
} |
circular dichroism studies on filamentous virus coat protein in lipid vesicles show that distinctive spectra result depending on the history of the protein and the method of vesicle preparation . | NA | {
"id": "C0042736",
"name": "virus",
"pos": [
42,
47
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
148,
155
]
} |
exposure to a ph of 3.8 in the presence of 8.0 m urea labilized the manganese and allowed the preparation of a colorless and inactive apoenzyme which could be reconstituted by subsequent treatment with mncl2 . | NA | {
"id": "C0024706",
"name": "manganese",
"pos": [
68,
77
]
} | {
"id": "C0065642",
"name": "mncl2",
"pos": [
202,
207
]
} |
the restriction endonuclease ecor1 cleaves saccharomyces cerevisiae dna , which codes for ribosomal rna ( rrna ) , into seven fragments , a second restriction endonuclease , hindiii , cleaves the same yeast ribosomal dna into two fragments . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
68,
71
]
} | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
207,
220
]
} |
covalent immobilization of soluble and enzymically active adenine nucleotide coenzymes by a single step procedure . | NA | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
58,
76
]
} | {
"id": "C0009226",
"name": "coenzymes",
"pos": [
77,
86
]
} |
amino acid analysis of the purified tau peptide revealed a relatively high concentration of the amino acids lysine and alanine , and a lack of detectable proline , tyrosine , phenylalanine , and methionine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
96,
107
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
181,
188
]
} |
heterologous human lipoproteins were infused into rats in order to change acutely the lipoprotein pattern to a predominant kind and the effect on hepatic cholesterogenesis was subsequently observed . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
19,
31
]
} | {
"id": "C0065058",
"name": "lipoprotein",
"pos": [
86,
97
]
} |
properties of the immobilized enzyme are described and compared with those of the native enzyme . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
18,
36
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
89,
95
]
} |
the immobilized enzyme was much more stable than the native enzyme at 37 degrees c . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
4,
22
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
60,
66
]
} |
the apparent michaelis constants measured for the immobilized enzyme were not greatly different from those measured for the native enzyme . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
50,
68
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
131,
137
]
} |
adhesion of baby hamster kidney fibroblasts ( bhk cells ) to a falcon tissue culture flask was measured under various physiological conditions . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
32,
43
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} |
diploid human fibroblasts and lymphocytes were fused with the cells of a malignant mouse melanoma and a range of hybrid clones selected for study . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
14,
25
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
62,
67
]
} |
influence of modified nucleosides in e. coli transfer ribonucleic acids on chromatographic mobilities of transfer rna . | NA | {
"id": "C0035711",
"name": "ribonucleic acids",
"pos": [
54,
71
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
114,
117
]
} |
derivatives of such related substances as cytosine , uracil , thymine , 6-methyl-uracil , 5-ethyluracil , 5-propyluracil , 5-isopropyluracil , 5-cyclopropyluracil , 5-allyluracil , 5,6-trimethyleneuracil , 6-cyclopropyluracil , 5-cyclobutyluracil and 5-tert-butyluracil have been separated on a column of spheron p-300 . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
62,
69
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
263,
269
]
} |
gas-liquid chromatographic ( glc ) analysis of phenobarbital by on-column methylation with trimethylanilinium hydroxide gives rise to a major decomposition product , n-methyl-2-phenylbutyramide , in addition to the methylated barbiturate , n , n'-dimethylphenobarbital . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
47,
60
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
226,
237
]
} |
this decomposition is shown to be inhibited by certain solvents and this effect forms the basis of a new analytical technique for the simultaneous glc analysis of phenobarbital , primidone , and diphenylhydantoin . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
163,
176
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
179,
188
]
} |
use of ethyl ethers , deuteriomethyl ethers and cyclic n-butylboronates of hydroxychlorobiphenyls in identification of metabolites of polychlorinated biphenyls . | NA | {
"id": "C0015060",
"name": "ethyl ethers",
"pos": [
7,
19
]
} | {
"id": "C0014996",
"name": "ethers",
"pos": [
37,
43
]
} |
[ separation and fluorimetric determination of adrenaline and noradrenaline . combination of a high-pressure liquid chromatograph with an automatic analysis system ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
47,
57
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
62,
75
]
} |
the possibilities for a high-pressure liquid chromatographic analysis combined with automatic fluorimetric detection of the catecholamines adrenaline and noradrenaline are described . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
139,
149
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
154,
167
]
} |
the optimal conditions are given for a fast separation by ion exchange and reversed-phase chromatography , and for the sensitive fluorimetric determination of adrenaline by the trihydroxyindole technique when a high excess of noradrenaline is present . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
159,
169
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
226,
239
]
} |
synthesis of liver protein and proalbumin were enhanced by chronic ethanol feeding , but this was not associated with a corresponding rise in serum albumin output . | NA | {
"id": "C0032923",
"name": "proalbumin",
"pos": [
31,
41
]
} | {
"id": "C0036773",
"name": "serum",
"pos": [
142,
147
]
} |
the important new discovery brought to light by quantitation of immunoassayable somatomedin in patient sera is that all previously used assays detect , in addition to somatomedin-c , serum substances that are not under as stringent growth hormone control . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
80,
91
]
} | {
"id": "C0021665",
"name": "somatomedin-c",
"pos": [
167,
180
]
} |
the small intestine is capable of taking up peptide nutrients of two or three amino acid residues , but the mechanism of intestinal assimilation of larger oligopeptides has not been established . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
44,
51
]
} | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
155,
168
]
} |
in contrast , when the rabbits were treated with nahco3 , their urine was significantly more alkaline , and their tubules studied in vitro generally secreted bicarbonate ( i.e. , net bath-to-lumen transport ) . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
49,
55
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
158,
169
]
} |
the bound lipoproteins had more cholesterol and cholesterol ester and less triglyceride than the unbound . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
32,
43
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
48,
65
]
} |
transiently increased cyclic amp concentrations , either exogenously added as 8-bromo-cyclic amp or endogenously produced by isoproterenol , promoted colchicine suppression of mediator release suggesting that microtubular disassembly was produced . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
22,
32
]
} | {
"id": "C0000661",
"name": "8-bromo-cyclic amp",
"pos": [
78,
96
]
} |
because most cases occur in young children , a high level of suspicion is necessary , because the oral manifestations and radiographic findings in children may often resemble the periapical , periodontal or cystic involvements frequently seen first by the dentist . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
28,
42
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
147,
155
]
} |
rapid access to analogoues of phalloidin by replacing alanine-1 in the natural toxin by other amino acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
54,
61
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
94,
105
]
} |
there were large excesses of all essential amino acids , with threonine being the most limiting . | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
33,
54
]
} | {
"id": "C0040005",
"name": "threonine",
"pos": [
62,
71
]
} |
the antigenic determinants on in situ tumor cells are not saturated with antibody as these cells demonstrated enhanced fluorescence of all immunoglobulin classes and subclasses when treated with autologous serum . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
73,
81
]
} | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
139,
161
]
} |
the remaining viable cell population was tested for mulv production ( in an infectious center assay on s+l-fibroblasts ) , for lethal effect on newborn mice , and for immunosuppressive activity . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
21,
25
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
107,
118
]
} |
a reproducible immunologic classification of neisseria gonorrhoeae strains has been achieved by the micro-immunofluorescence ( micro-if ) 3 method by using formalinized whole organisms as test antigens and mouse antisera prepared by i.v . immunization with the whole organisms as antibody . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
212,
220
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
280,
288
]
} |
the surface expression of a recently described plasma glycoprotein called human complex-forming glycoprotein , hetergeneous in charge ( protein hc ) on a number of different human cell types was investigated . | NA | {
"id": "C0025248",
"name": "surface",
"pos": [
4,
11
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
96,
108
]
} |
20alpha-hydroxysteroid dehydrogenase ( 20alpha-sdh ) , an enzyme which reduces progesterone to 20alpha-dihydroprogesterone , was found to be associated with t lymphocytes . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
79,
91
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
103,
122
]
} |
progesterone ( 5.0 x 10 ( -7 ) m ) was found to inhibit thymocyte proliferation after exposure to mitogens , but not 20alpha-dihydroprogesterone ( 10 ( -6 ) m ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
0,
12
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
125,
144
]
} |
this antigen was not adsorbed to cm cellulose , migrated cathodal to guinea pig albumin on electrophoresis , and was adsorbed to deae cellulose . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
36,
45
]
} | {
"id": "C0011050",
"name": "deae cellulose",
"pos": [
129,
143
]
} |
specific binding was not inhibited by a large excess of antigen in the media ( 5000-fold greater than the amount of antigen associated with the macrophages ) either soluble or bound to sepharose beads , or by coating the antigen-pulsed macrophags with antibody to the exogenous antigen , by reacting a second layer of antibody to the heterologous antibody , or by haptenating the antigen and treating the hapten-antigen macrophage complex with excess anti-hapten antibody . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
252,
260
]
} | {
"id": "C0003313",
"name": "antigen",
"pos": [
412,
419
]
} |
( 6 ) levels of antibody in colonized children were lower in those younger than two years than in older children ( p less than 0.001 ) ; | NA | {
"id": "C0008059",
"name": "children",
"pos": [
38,
46
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
98,
112
]
} |
antibody to cell wall glycolipid of gram-negative bacteria : induction of immunity to bacteremia and endotoxemia . | NA | {
"id": "C0004610",
"name": "bacteremia",
"pos": [
86,
96
]
} | {
"id": "C0376618",
"name": "endotoxemia",
"pos": [
101,
112
]
} |
these molecules which removed opsonic antibodies from immune serum could be separated from those proteins that had only type specificity . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
38,
48
]
} | {
"id": "C0020960",
"name": "immune serum",
"pos": [
54,
66
]
} |
endotoxin ( lipopolysaccharide , lps ) has been found to act on all three cell types of the immune system , thymus-derived ( t- ) cells , bone marrow-derived ( b- ) cells , and macrophages . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
0,
9
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
33,
36
]
} |
the methodology for measuring in vivo oxidation of substrates labeled with the nonradioactive carbon isotope 13c has been developed with isotope ratio mass spectrometry . | NA | {
"id": "C0007017",
"name": "carbon isotope",
"pos": [
94,
108
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
137,
144
]
} |
the rate of ( 125 ) i-hdl degradation by cultured fibroblasts ( per unit cell mass ) exceeded an estimate of the turnover rate of hdl in vivo , suggesting that peripheral tissues may contribute to hdl catabolism . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
50,
61
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
73,
77
]
} |
it is concluded that : 1 ) the arginine-rich apoprotein is a major apolipoprotein whereas apoprotein a-i is a minor apolipoprotein secreted by the perfused rat liver ; | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
45,
55
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
116,
130
]
} |
human fibroblasts from normal subjects , sv40 tumor virus-transformed cell lines , and homozygous familial hypercholesterolemic cells as reference , were grown in tissue culture . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
6,
17
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
128,
133
]
} |
monolayers of virus-transformed tumor cells exhibited specific ( 125 ) i-labeled ldl binding of 152 +/- 21 ng/mg cell protein , which was essentially the same as that of normal fibroblasts ( 135 +/- 20 ng/mg ) . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
38,
42
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
177,
188
]
} |
this was accompanied in each case by increased levels of serum somatomedin ( primarily somatomedin c ) . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
63,
74
]
} | {
"id": "C0021665",
"name": "somatomedin c",
"pos": [
87,
100
]
} |
hormone release was unchanged by the presence of exogenous insulin as judged by determination of both immunoreactive insulin and radioactivity incorporated into the proinsulin and insulin fractions of the medium . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
165,
175
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
180,
187
]
} |
hormone specificity studies indicated that binding was specific for hormones with prolactin-like activity ( hgh , prolactins ) and not for growth hormones themselves ( bgh ) . | NA | {
"id": "C0169964",
"name": "hgh",
"pos": [
108,
111
]
} | {
"id": "C0037663",
"name": "growth hormones",
"pos": [
139,
154
]
} |
the skin from four species of north american tree frogs ( hylidae ) was found in vitro , to be remarkably permeable to water in the presence or absence of the neurohypophysial hormone vasotocin . | NA | {
"id": "C0032017",
"name": "neurohypophysial hormone",
"pos": [
159,
183
]
} | {
"id": "C0042418",
"name": "vasotocin",
"pos": [
184,
193
]
} |
murine leukemia virus-related antigens and alloantigens on cultured fibroblasts and sarcoma cells : description of a unique antigen on balb/c meth a sarcoma . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
68,
79
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
92,
97
]
} |
in nonproducer lines of c57bl/6 ( but not balb/c ) origin , a mulv-gp70-like molecule was found on the surface of fibroblasts and sarcoma cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
114,
125
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
138,
143
]
} |
a variety of anti-ig reagents , some of which block b-abc , do not inhibit t-abc suggesting that variable regions on t cells are not linked to ig constant regions . | NA | {
"id": "C0021027",
"name": "ig",
"pos": [
18,
20
]
} | {
"id": "C0021008",
"name": "ig constant regions",
"pos": [
143,
162
]
} |
at all times examined , from day 3 to day 6 of the proliferative response , syngeneic spleen cells presented antigen better to peritoneal exudate t-lymphocyte-enriched cells ( petles ) than semisyngeneic f ( 1 ) spleen cells , which in turn could present antigen better than totally allogeneic spleen cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
93,
98
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
283,
293
]
} |
uninfected balb/c-h-2 ( db ) cells stimulated a normal t ( c ) -cell response to minor h antigens or trinitrophenyl in association with h-2d ( d ) , thus suggesting that the defective response to infection may reside in a failure of the relevant h-2d ( d ) antigens of mutant cells to physically associate with viral antigens . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
89,
97
]
} | {
"id": "C0003342",
"name": "viral",
"pos": [
311,
316
]
} |
amino acid and carbohydrate analysis showed predominance of the acidic amino acids , lack of proline , and absence of carbohydrate . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0815040",
"name": "acidic amino",
"pos": [
64,
76
]
} |
we conclude that after vaccination , antibody-forming cells arise and provide specific anti-viral antibody and that the cytotoxic cells detected in this reaction are k cells . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
37,
45
]
} | {
"id": "C0003253",
"name": "anti-viral",
"pos": [
87,
97
]
} |
the procedure consists of acetylation of the total lipids after extraction , separation of acetylated glycophingolipids from non-glycolipids on a florisil column , deacetylation , dialysis in water , separation of the single fractions by thin-layer chromatography on silica gel , and quantitative analysis of each glycosphingolipid by sulfuric acid-orcinol reagent , carried out in the presence of silica gel . | NA | {
"id": "C0017950",
"name": "glycolipids",
"pos": [
129,
140
]
} | {
"id": "C0017978",
"name": "glycosphingolipid",
"pos": [
314,
331
]
} |
the semiautomatic separation of the catecholamines , adrenaline and noradrenaline , is based on their adsorption onto aluminium oxide at ph 8.4 , followed by batch elution with 0.05 mol/1 perchloric acid . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
53,
63
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
68,
81
]
} |
two-thirds of the cytoplasmic rna labeled during a 4-hour period is 25-30 x 10 ( 3 ) daltons in size , and some of this low molecular weight rna can be aminoacylated and shown to be transfer rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
30,
33
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
182,
194
]
} |
if chloride is lowered by replacement with the permeant anion , acetate , e ( cl ) is unchanged and a normal response to norepinephrine , which is inhibited by furosemide , is observed . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
3,
11
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
56,
61
]
} |
both in the case of cl ( - ) ( 15 degrees c ) and in the case of br ( - ) ( 25 degrees c ) , critical temperature was reached when the anion self-exchange had a turnover number of about 4x10 ( 9 ) ions cell ( -1 ) s ( -1 ) ; | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
135,
140
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
197,
201
]
} |
the antibacterial effects of mev are the consequences of repairable damage to dna , as shown by hypersensitivity of reca and uvr strains to mev and related drugs , stimulation by mev of dna turnover which was dependent on the product of the uvra gene , and the presence of cross-links in dna from mev-treated bacteria . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
78,
81
]
} | {
"id": "C0012924",
"name": "dna",
"pos": [
288,
291
]
} |
glucosamine- or n-acetylglucosamine-requiring mutants of staphylococcus aureus 209p and escherichia coli k12 , which lack glucosamine-6-phosphate synthetase [ 2-amino-2-deoxy-d-glucose-6-phosphate ketol-isomerase ( amino-transferring ) ; ec 5.3.1.19 ] , were isolated . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
0,
11
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
16,
35
]
} |
growth of these mutants on glucosamine was inhibited by glucose , but growth on n-acetylglucosamine was not . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
27,
38
]
} | {
"id": "C0001056",
"name": "acetylglucosamine",
"pos": [
82,
99
]
} |
the differences in radioactivity between the dorsal root and sciatic nerve proteins were mainly quantitative and not qualitative , with many proteins of various molecular weight ranges being transported into both segments . | NA | {
"id": "C0027759",
"name": "nerve proteins",
"pos": [
69,
83
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
141,
149
]
} |
feeding a pyridoxine deficient diet , for 2 weeks after hatching , had no effect on post-hatching development of chick brain aspartate aminotransferase ( l-aspartate:2-oxoglutarate aminotransferase , ec 2.6.1.1 ) activity or on cholesterol deposition in the brain , but significantly depressed the development of brain alanine aminotransferase ( l-alanine:2-oxoglutarate aminotransferase , ec 2.5.1.2 ) activity . | NA | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
125,
151
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
371,
387
]
} |
feeding a pyridoxine deficient diet , for 2 weeks after hatching , had no effect on post-hatching development of chick brain aspartate aminotransferase ( l-aspartate:2-oxoglutarate aminotransferase , ec 2.6.1.1 ) activity or on cholesterol deposition in the brain , but significantly depressed the development of brain alanine aminotransferase ( l-alanine:2-oxoglutarate aminotransferase , ec 2.5.1.2 ) activity . | NA | {
"id": "C0001899",
"name": "alanine aminotransferase",
"pos": [
319,
343
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
371,
387
]
} |
amounts of free typtophan and alanine in livers of derpived rats decreased to 40 % of the controls after 15 days , whereas amounts of most other amino acids were nearly constant . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
30,
37
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
145,
156
]
} |
nonischemic intussusception is defined as a variant of acute intussusception exhibiting less acute symptoms of abdominal pain , vomiting , and diarrhea in the older child , longer duration of symptoms ( usually 4-14 days ) , signs of imcomplete bowel obstruction , and absence of intestinal ischemia . | NA | {
"id": "C0021933",
"name": "intussusception",
"pos": [
12,
27
]
} | {
"id": "C0021843",
"name": "of",
"pos": [
277,
279
]
} |
the aim of the present investigation was to examine the fetal and maternal blood glucose and insulin response following glucose infusion to the mother . | NA | {
"id": "C0005802",
"name": "blood",
"pos": [
75,
80
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
120,
127
]
} |
in vitro investigation of the diffusion of anhydrous ampicillin and ampicillin trihydrate from different ointments and ointment bases . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
53,
63
]
} | {
"id": "C0700443",
"name": "ampicillin",
"pos": [
68,
78
]
} |
the true leaves of the thc type contained a relatively high content of thc and also contained cannabichromene ( cbc ) , sometimes as the major cannabinoid , whereas the cbd type had much lower amounts of thc and no cbc ; | NA | {
"id": "C0006864",
"name": "cannabinoid",
"pos": [
143,
154
]
} | {
"id": "C0039663",
"name": "thc",
"pos": [
204,
207
]
} |
a glc method for the determination of plasma isosorbide dinitrate and two metabolites , isosorbide 2-mononitrate and isosorbide 5-mononitrate , is described . | NA | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
45,
65
]
} | {
"id": "C0064079",
"name": "isosorbide 5-mononitrate",
"pos": [
117,
141
]
} |
the d- and l-isomers of methadone were equipotent inhibitors of aortic contraction . l-acetylmethadol ( 1 x 10 ( -6 ) -1 x 10 ( -5 ) m ) was a potent inhibitor of vascular contraction . l-pentazocine inhibited its own ability to contract the aorta as the dose was raised 3 x 10 ( -5 ) m . | NA | {
"id": "C0025605",
"name": "methadone",
"pos": [
24,
33
]
} | {
"id": "C0025607",
"name": "acetylmethadol",
"pos": [
87,
101
]
} |
the inhibition of aortic contraction produced by methadone , l-acetylmethadol and l-pentazocine was overcome by raising the concentration of calcium in the tissue baths . | NA | {
"id": "C0025605",
"name": "methadone",
"pos": [
49,
58
]
} | {
"id": "C0025607",
"name": "acetylmethadol",
"pos": [
63,
77
]
} |
since calcium is a critical regulator of cellular function , the calcium-antagonist action of methadone and l-acetylmethadol may prove to be important in mediating some of their pharmacologic and toxicologic effects . | NA | {
"id": "C0025605",
"name": "methadone",
"pos": [
94,
103
]
} | {
"id": "C0025607",
"name": "acetylmethadol",
"pos": [
110,
124
]
} |
the resting cyclic amp level was 2-4 p-mole/mg protein and the cyclic gmp level was 0-27 p-mole/mg protein in desheathed nerves . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
47,
54
]
} | {
"id": "C0027759",
"name": "protein",
"pos": [
99,
106
]
} |
five per cent cancelled their bookings , 26 per cent were transferred to a consultant unit after referral for routine problems of pregnancy ( mainly postmaturity ) , and 14 per cent were transferred for problems arising in labour ( principally uterine inertia ) . | NA | {
"id": "C0013418",
"name": "transferred",
"pos": [
58,
69
]
} | {
"id": "C0042135",
"name": "uterine inertia",
"pos": [
244,
259
]
} |
of 740 teenagers examined for gonorrhea and syphilis , 2,4 % were found to have gonorrhea , whereas 0.6 % had primary syphilis . | NA | {
"id": "C0039128",
"name": "syphilis",
"pos": [
44,
52
]
} | {
"id": "C0007939",
"name": "primary syphilis",
"pos": [
110,
126
]
} |
in this communication it is documented that the compound formed by catalytic reduction of ( - ) -alprenolol with tritium gas is the saturated product ( - ) - [ 3h ] dihydroalprenolol in which tritium is added across the double bond and exchanged into the adjacent benzylic position . | NA | {
"id": "C0002334",
"name": "alprenolol",
"pos": [
97,
107
]
} | {
"id": "C0012278",
"name": "dihydroalprenolol",
"pos": [
165,
182
]
} |
the biological activity of ( - ) - [ 3h ] dihydroalprenolol , dihydroalprenolol , and alprenolol was also shown to be identical as assessed by direct ligand binding and inhibition of catecholamine-stimulated adenylate cyclase . | NA | {
"id": "C0012278",
"name": "dihydroalprenolol",
"pos": [
42,
59
]
} | {
"id": "C0002334",
"name": "alprenolol",
"pos": [
86,
96
]
} |
epimeric 6-amino derivatives of naloxone and naltrexone have been synthesized and the configuration at the c-6 chiral center was determined from nmr studies . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
32,
40
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
45,
55
]
} |
it is suggested that a disk containing trimethoprim and sulphamethoxazole in a ratio of 1 : 2 rather than 1 : 20 would be more appropriate when testing strains from urine for their sensitivity to co-trimoxazole . | NA | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
56,
73
]
} | {
"id": "C0041044",
"name": "co-trimoxazole",
"pos": [
196,
210
]
} |
if , however , iron in the form of ferric citrate was added to the medium , reversion occurred and type 1 colonies rapidly came to predominate . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
15,
19
]
} | {
"id": "C0060231",
"name": "ferric citrate",
"pos": [
35,
49
]
} |
when t7 dna damaged by uv irradiation was treated with an endonuclease from micrococcus luteus that is specific for pyrimidine dimers and then was incubated with an extract of uninfected e. coli capable of removing pyrimidine dimers and restoring the dna of its original ( whole genome size ) molecular weight , this dna showed a higher packaging efficiency than untreated dna , thus demonstrating that the in vitro repair system partially restored the biological activity of uv-damaged dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
8,
11
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
489,
490
]
} |
this cdna was shown not to anneal to moloney mlv rna and to anneal to a portion of the viral rna of about 1,500 to 1,800 nucleotides in length , located 1,000 nucleotides from the 3 ' end of msv rna . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
87,
96
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
195,
198
]
} |
whole-cell rna and nuclear rna annealed to 60 and 40 % , respectively , of l and r strands . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
11,
14
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
19,
30
]
} |
in whole-cell rna and nuclear rna the abundant classes were 57 to 208 and 13 to 27 times more concentrated , respectively , than scarce classes . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
14,
17
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
22,
33
]
} |
rna-rna hybrids were isolated that annealed to about 70 % of both strands , indicating that whole-cell rna and nuclear rna hybridization values were minimal . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
0,
3
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
111,
122
]
} |
two such proteins are seen , one of which is evidently the gene 25 product and one that is a bacterial protein . | NA | {
"id": "C0033684",
"name": "gene",
"pos": [
59,
63
]
} | {
"id": "C0004627",
"name": "bacterial protein",
"pos": [
93,
110
]
} |
a precise value for the size of the terminal repetition in t5 dna was obtained by analyzing si endonuclease digests of ligase-repaired , circular t5 dna in agarose gels . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
62,
65
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
137,
145
]
} |
two virion rna species ( l and s ) , but no 18s rrna species , were detected in pichinde virus preparations obtained from infected bhk-21 cells . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
11,
14
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
48,
52
]
} |
significantly ( p less than .01 ) greater mortality and eventual disability occurred in patients excreting more than 200 microgram of urinary norepinephrine and epinephrine daily early in their acute illness . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
142,
156
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
161,
172
]
} |
[ anti-shock effect of reduced glutathione . effects on survival rate and metabolism in traumatic shock rats ] . | NA | {
"id": "C0036974",
"name": "shock",
"pos": [
7,
12
]
} | {
"id": "C0036986",
"name": "traumatic shock",
"pos": [
88,
103
]
} |
felty 's syndrome appears to be a variant of rheumatoid arthritis with extra-articular manifestations in which leukopenia ( usually due to neutropenia ) and splenomegaly occur , although not always at the same time . | NA | {
"id": "C0015773",
"name": "felty 's syndrome",
"pos": [
0,
17
]
} | {
"id": "C0003873",
"name": "rheumatoid",
"pos": [
45,
55
]
} |
micrometric studies of the sarcomeres of myocytes in the zone of experimentally induced myocardial ischaemia in rats , histological , polarization-microscopic and micrometric studies of the myocardial cells in the zone of infarction in dead humans and model experiments with fixation of distended papillary muscles demonstrated that relaxation of the sarcomeres is characteristic of the myocardial cells damaged by ischaemia . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
222,
232
]
} | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
415,
424
]
} |
most probably it is attributable to the presence of lipoprotein particles with a quantitatively different protein and lipid composition , probably of intermediate lipoprotein metabolites in blood plasma , or conformation changes in the structure of low density lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
118,
123
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
261,
272
]
} |
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