text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
at birth there is a statistically significant correlation between the maternal blood sugar and the umbilical venous and arterial blood glucose . | NA | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
79,
90
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
135,
142
]
} |
a mean maximum serum concentration of pa of 5.78 mg/l was obtained with a loading infusion of 16.6 mg/min pa hcl . | NA | {
"id": "C0033216",
"name": "pa",
"pos": [
38,
40
]
} | {
"id": "C0600311",
"name": "pa hcl",
"pos": [
106,
112
]
} |
an average steady-state serum concentration of pa of 5.05 mg/l was obtained with a mean maintenance infusion of 222 mg/hour pa hcl . | NA | {
"id": "C0033216",
"name": "pa",
"pos": [
47,
49
]
} | {
"id": "C0600311",
"name": "pa hcl",
"pos": [
124,
130
]
} |
the side-effects were well controlled by the anticholinergic agent oxyphenonium bromide ( antrenyl ) and a slight increase in the dose of nitrates . | NA | {
"id": "C0086757",
"name": "oxyphenonium bromide",
"pos": [
67,
87
]
} | {
"id": "C0030082",
"name": "antrenyl",
"pos": [
90,
98
]
} |
cephamandol 6.0 g , cephazolin 6.0 g or cephacetrile or cephalothin 8.0 g were administered as short-term infusions on 3 consecutive days to informed volunteers , who had no history or evidence of impairment of renal function . | NA | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
40,
52
]
} | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
56,
67
]
} |
there were 15 subjects in the cephamandol , cephacetrile and cephalothin groups and 14 subjects in the cephazolin group . | NA | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
44,
56
]
} | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
61,
72
]
} |
an experimental model system is presented for the investigation in humans of the role of hematopoietic stromal elements in the regulation of hematopoiesis as well as in the pathogenesis of myelofibrosis in myeloproliferative disorders . | NA | {
"id": "C0001815",
"name": "myelofibrosis",
"pos": [
189,
202
]
} | {
"id": "C0027022",
"name": "myeloproliferative disorders",
"pos": [
206,
234
]
} |
human diploid fibroblasts deplete 50 % of their cellular glycogen by day 4 after subcultivation in 100 mg % glucose medium . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
14,
25
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
48,
56
]
} |
satellite dna ( ii ) appears in between the main band dna ( rho = 1.695 g/cm3 ) and the rdna satellite ( rho = 1.722 g/cm3 ) . | NA | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
0,
13
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
89,
92
]
} |
shortening the plasma coagulation time according to the thromboplastic activity after quick occurs through activation of the factor x proceeding against the background of falling activity of some other coagulation factors and comes as a result of excess 2.5-ionene in the blood . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
125,
133
]
} | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
202,
221
]
} |
a distinct summertime skin disorder seen in 25 indian patients is described under a tentative designation of summertime actinic lichenoid eruption ( sale ) . | NA | {
"id": "C0037274",
"name": "skin disorder",
"pos": [
22,
35
]
} | {
"id": "C0015230",
"name": "eruption",
"pos": [
138,
146
]
} |
haeme binding to human serum albumin and to the three large cyanogen bromide albumin fragments . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
17,
36
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
77,
84
]
} |
the extent of removal and metabolism of chylomicrons and chylomicron remnants by the individual lobes of the perfused rat liver [ proceedings ] . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
40,
52
]
} | {
"id": "C0443616",
"name": "chylomicron remnants",
"pos": [
57,
77
]
} |
effect of a pulsatile hepatic-vein pressure on the removal and metabolism of chylomicrons and chylomicron remnants by individual lobes of the perfused rat liver [ proceedings ] . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
77,
89
]
} | {
"id": "C0443616",
"name": "chylomicron remnants",
"pos": [
94,
114
]
} |
in experiment 1 , group 1 rats received a diet containing unprocessed dry bracken powder for 3 months , group 2 received the boiling water extract of dry bracken as drinking water for 16 months , group 3 received the cold water extract of dry bracken as drinking water for 16 months , and group 4 received a diet containing the concentrated boiling water extract of dry bracken during the whole experimental period . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
133,
138
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
254,
268
]
} |
we have classified esophageal trauma into three major categories : ( 1 ) iatrogenic trauma including endoscopic perforation , trauma due to dilatation , surgical trauma , tube trauma , radiation trauma , and drug trauma ; | NA | {
"id": "C0034530",
"name": "radiation trauma",
"pos": [
185,
201
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
213,
219
]
} |
the specific binding of wheat germ agglutinin , a dietary plant lectin , to n-acetylglucosamine was used as the basis for purification of this lectin by biospecific chitin affinity chromatography . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
58,
70
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
143,
149
]
} |
in pentobarbital-anesthetized rats or in perfused hind paw of rats , the potentiation induced by cocaine and tripelennamine was more marked to norepinephrine than to epinephrine , but an inverse relation between norepinephrine and epinephrine was observed in the potentiation by i and ii . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
143,
157
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
231,
242
]
} |
the episodic symptom group is made up of pathologically abnormal experiences such as hallucinations and delusions and symptoms due to a decline in the level of consciousness such as confusion , delirium and twilight state . | NA | {
"id": "C0009676",
"name": "confusion",
"pos": [
182,
191
]
} | {
"id": "C0011206",
"name": "delirium",
"pos": [
194,
202
]
} |
[ microbiological evaluation of cefoxitin , a new beta-lactamase resistant cephamycin antibiotic , compared to cephalothin , cephaloridine and cefazolin ] . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
32,
41
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
75,
85
]
} |
of the gramnegative microorganisms a selection of 150 strains was examined regarding susceptibility to the antibiotic combinations cefoxitin/gentamicin and cefoxitin/sisomicin in comparison to cephalothin/gentamicin and cephalothin/sisomicin . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
141,
151
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
232,
241
]
} |
we have evaluated the effect of serotonin ( 5-ht ) and of its biosynthetic precursors 5-hydroxytryptophan ( 5-htp ) and tryptophan ( trp ) on the release of immunoreactive glucagon ( irg ) and insulin ( iri ) from isolated islets and pieces of pancrease of the rat . | NA | {
"id": "C0000578",
"name": "5-htp",
"pos": [
108,
113
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
120,
130
]
} |
trp stimulated the irg and iri response to the low glucose concentration , while 5-htp was ineffective . | NA | {
"id": "C0041249",
"name": "trp",
"pos": [
0,
3
]
} | {
"id": "C0000578",
"name": "5-htp",
"pos": [
81,
86
]
} |
in vitro incubation of anterior pituitary fragments with glucagon failed to decrease the release of gh , suggesting that glucagon does not act directly on the anterior pituitary . | NA | {
"id": "C0037663",
"name": "gh",
"pos": [
100,
102
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
159,
177
]
} |
since cyclic amp and dibutyryl cyclic amp ( dbc ) stimulated lh release , it is suggested that eb directly stimulates the release of lh by augmenting cyclic amp synthesis in the anterior pituitary . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
6,
16
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
21,
41
]
} |
by analogy , the increased o2 affinity of human fetal hemoglobin is interpreted according to previous physiological investigations on blood and fetal hemoglobin by the inactivation of the phosphoglycerate contact point beta143 his in the adult hemoglobin by mutation to gamma 143 ser in the fetal hemoglobin . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
54,
64
]
} | {
"id": "C0015936",
"name": "fetal hemoglobin",
"pos": [
291,
307
]
} |
two cyclic amp-binding proteins , not identical with regulatory subunits of protein kinases , have been isolated from trypanosoma gambiense . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
23,
31
]
} | {
"id": "C0599220",
"name": "subunits",
"pos": [
64,
72
]
} |
the biological function of esterase isoenzymes appears to represent an extension of the range of hydrolytic competence of a single enzyme . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
36,
46
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
131,
137
]
} |
crossed immunoelectrophoresis with antiserum against granulocyte elastase did not reveal the presence of elastase components with the electrophoretic mobility of free elastase , but elastase-alpha1-antitrypsin complexes were detected . | NA | {
"id": "C0064833",
"name": "granulocyte elastase",
"pos": [
53,
73
]
} | {
"id": "C0030306",
"name": "elastase",
"pos": [
182,
190
]
} |
characterization of the modified protein and the binding of l-tryptophan and benzodiazepines to the tryptophan-modified albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
33,
40
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
120,
127
]
} |
of these , the adenocarcinomas constituted the largest group , but because some of them bore a certain likeness to adenoid cystic carcinomas and to mucoepidermoid tumours , we believe that transitions exist between these groups of neoplasms . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
15,
30
]
} | {
"id": "C0010606",
"name": "adenoid cystic",
"pos": [
115,
129
]
} |
to investigate immunogenetics of leprosy , 205 leprosy patients ( 26 with tuberculoid , 57 with borderline-tuberculoid , 21 with borderline , 31 with borderline-lepromatous , and 70 with lepromatous leprosy ) have been typed for hla antigens , and compared with 183 healthy controls from the same region ( northern thailand ) . | NA | {
"id": "C0023343",
"name": "leprosy",
"pos": [
33,
40
]
} | {
"id": "C1562908",
"name": "borderline-tuberculoid",
"pos": [
96,
118
]
} |
to investigate immunogenetics of leprosy , 205 leprosy patients ( 26 with tuberculoid , 57 with borderline-tuberculoid , 21 with borderline , 31 with borderline-lepromatous , and 70 with lepromatous leprosy ) have been typed for hla antigens , and compared with 183 healthy controls from the same region ( northern thailand ) . | NA | {
"id": "C0023343",
"name": "leprosy",
"pos": [
33,
40
]
} | {
"id": "C1562585",
"name": "borderline-lepromatous",
"pos": [
150,
172
]
} |
to investigate immunogenetics of leprosy , 205 leprosy patients ( 26 with tuberculoid , 57 with borderline-tuberculoid , 21 with borderline , 31 with borderline-lepromatous , and 70 with lepromatous leprosy ) have been typed for hla antigens , and compared with 183 healthy controls from the same region ( northern thailand ) . | NA | {
"id": "C1562585",
"name": "borderline-lepromatous",
"pos": [
150,
172
]
} | {
"id": "C0023348",
"name": "lepromatous leprosy",
"pos": [
187,
206
]
} |
nadh-cytochrome b5 reductase ( dia1 , ec . 1.6.2.2 ) from human fibroblasts and from chinese hamster cells , both identified by immunologic studies , were clearly distinguished after polyacrylamide gel isoelectro-focusing followed by staining for nadh diaphorase activity . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
64,
75
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
101,
106
]
} |
microcephaly and craniofacial dysmorphia , cleft palate , cardiac malformation , and hypospadias are observed in a child with 46 , xy , del ( 1 ) ( q42 ) . | NA | {
"id": "C0025958",
"name": "microcephaly",
"pos": [
0,
12
]
} | {
"id": "C0376634",
"name": "craniofacial dysmorphia",
"pos": [
17,
40
]
} |
in a sibship of ten children descending from a first cousin 's marriage , two sibs were affected by kartagener 's syndrome with the typical symptoms of situs inversus , bronchiectasis , and polyposis nasi . | NA | {
"id": "C0022521",
"name": "kartagener 's syndrome",
"pos": [
100,
122
]
} | {
"id": "C0006267",
"name": "bronchiectasis",
"pos": [
169,
183
]
} |
and 49 , xxxxx chromosomal constitution , and in fibroblasts from a patient with xeroderma pigmentosum ( de sanctis-cacchione syndrome ) , the rate of dna replication does not differ from that in normal cells , varying in a single fork from 0.2 to 1.0 micrometer/min with a mean of about 0.6 micrometer/min . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
49,
60
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
196,
208
]
} |
transformed cells had the lowest activity found followed in increasing order by fibroblasts , human and bovine epithelial cells and monkey kidney epithelial cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
80,
91
]
} |
three chlorinated hydrocarbons , proposed or already in use as industrial substitutes for the hydrocarbon trichloroethylene , were tested for in vitro transforming potential in a fischer rat embryo cell system ( f1706 ) , which previously has been shown to be sensitive to transformation by chemical carcinogens . | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
6,
30
]
} | {
"id": "C0040905",
"name": "trichloroethylene",
"pos": [
106,
123
]
} |
neither aflatoxin-treated nor control cultures exhibited cytopathological morphology , formation of cell foci , growth in soft agar , or irregular fibroblast-like growth patterns that could be specifically related to the onset of tumorigenic potential . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
100,
104
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
147,
157
]
} |
in general , those parameters commonly used to monitor fibroblast cultures for transformation in vitro were not applicable for assessing the tumorigenic potential of these epithelial cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
55,
65
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
175,
178
]
} |
isolation from nurse shark serum of immune 7s antibodies with two different molecular weight h-chains . | NA | {
"id": "C0020960",
"name": "serum",
"pos": [
27,
32
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
46,
56
]
} |
the antibodies of these antisera responsible for specific immunosuppression could be absorbed onto adherent peritoneal exudate cells taken from daf1 but not sjl mice . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
24,
32
]
} |
among glass-adherent peritoneal exudate cells ( gapec ) , induced by an inoculation of 1 % glycogen solution , about 4.5 % were classified as antibody-forming cell precursors ( afcp ) on the first day of culture by means of anti-mouse b-cell antibody ( anti-b-ab ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
40,
45
]
} | {
"id": "C0018956",
"name": "cell",
"pos": [
237,
241
]
} |
aqueous phase and butanol phase extracts of group a1 , o , m , n , p1 and p2 human erythrocytes perpared by extraction of red cell stromata with n-butanol were examined for the presence of blood group substances in inhibition of agglutination experiments using antisera and test cells of human origin . | NA | {
"id": "C0001977",
"name": "butanol",
"pos": [
18,
25
]
} | {
"id": "C0089147",
"name": "n-butanol",
"pos": [
145,
154
]
} |
in contrast to conventional rats , the response of germfree rat splenocytes to ca was insignificant before challenge with c. albicans , and it was increased at 9 days after infection . | NA | {
"id": "C0982054",
"name": "ca",
"pos": [
79,
81
]
} | {
"id": "C0006837",
"name": "c",
"pos": [
177,
178
]
} |
staphylococcus aureus s-6 was able to utilize glutamate , proline , histidine , aspartate , alanine , threonine , serine , or glycine as a major energy source , when these were added singly at a concentration of 2.5 g/liter to a base medium containing salts , vitamins , and 30 mg of each of 18 amino acids per liter . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
92,
99
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
295,
306
]
} |
staphylococcus aureus s-6 was able to utilize glutamate , proline , histidine , aspartate , alanine , threonine , serine , or glycine as a major energy source , when these were added singly at a concentration of 2.5 g/liter to a base medium containing salts , vitamins , and 30 mg of each of 18 amino acids per liter . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
126,
133
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
295,
306
]
} |
the highest y values obtained with the other amino acids were 79 , 78 , 56 , 46 , 58 , and 21 g/mol for glutamate , proline , histidine , alanine , threonine , and glycine , respectively . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
45,
50
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
138,
145
]
} |
the highest y values obtained with the other amino acids were 79 , 78 , 56 , 46 , 58 , and 21 g/mol for glutamate , proline , histidine , alanine , threonine , and glycine , respectively . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
45,
50
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
164,
171
]
} |
enterotoxin yields ( mg of toxin per g [ dry wt ] of cells ) higher than in the basal medium were obtained when proline , histidine , alanine , serine , and glycine were the major energy sources . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
0,
11
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
27,
32
]
} |
when proline and alanine were the major energy sources , enterotoxin yields were not affected by the concentration , whereas toxin yields were reduced at high concentrations of the other six amino acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
17,
24
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
191,
202
]
} |
when proline and alanine were the major energy sources , enterotoxin yields were not affected by the concentration , whereas toxin yields were reduced at high concentrations of the other six amino acids . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
57,
68
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
125,
130
]
} |
adherence to monolayer cultures or cell suspensions of detroit cells compared favorably with adherence to suspensions of human oral epithelial cells . | NA | {
"id": "C0038960",
"name": "suspensions",
"pos": [
40,
51
]
} | {
"id": "C0991537",
"name": "suspensions",
"pos": [
106,
117
]
} |
the interferon was stable to ph 2.0 treatment , was produced in moderately high levels ( greater than 1,000 units ) , and met many of the criteria for classification as a type i interferon . | NA | {
"id": "C0021747",
"name": "interferon",
"pos": [
4,
14
]
} | {
"id": "C0021743",
"name": "type i interferon",
"pos": [
171,
188
]
} |
inverse relationship between the susceptibility of lipopolysaccharide ( lipid a ) -pretreated mice to the hypothermic and lethal effect of lipopolysaccharide . | NA | {
"id": "C0023767",
"name": "lipid",
"pos": [
72,
77
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
139,
157
]
} |
since reciprocal hyperreactivity ( day 1 ) and cross-tolerance to lethality ( day 4 ) could be achieved by treatment with salmonella smooth- or rough-form lps as well as with free lipid a , it was concluded that lipid a represents the active principle of lps in inducing both hyperreactivity and tolerance to the lethal effect of lps . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
180,
187
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
330,
333
]
} |
in plf cultures , the strains at initial concentrations of 10 ( 1.3 ) colony-forming units/ml increased within 3 days to 10 ( 6 ) colony-forming units/ml , showed progressive clustering on the cells , and caused some sloughing . | NA | {
"id": "C0016030",
"name": "plf",
"pos": [
3,
6
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
193,
198
]
} |
with 5 h postinoculation , m. hyopneumoniae cultures became intimately associated with the plf culture , but when epithelial cell sloughing occurred , the mycoplasmal cells became dependent on the introduction of a fresh plf monolayer or a tracheal or lung explant for survival . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
167,
172
]
} | {
"id": "C0016030",
"name": "plf",
"pos": [
221,
224
]
} |
k88 antigen , and important virulence factor in porcine enteropathogenic escherichia coli ( eec ) , can be transferred along with the ability to ferment the trisaccharide raffinose ( raf ) . | NA | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
157,
170
]
} | {
"id": "C0034632",
"name": "raffinose",
"pos": [
171,
180
]
} |
the partially purified glucosyltransferase ( gtf ) fraction synthesizing primarily water-insoluble glucans , gtf-a , and the homogeneous fraction synthesizing water-soluble glucans , gtf-b , were utilized to assess the binding of gtf activity to the cell surface of streptococcus mutans gs-5 . | NA | {
"id": "C0991883",
"name": "purified",
"pos": [
14,
22
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
159,
164
]
} |
additional data support the concept that natural antibody to either the polysaccharide or the lipid a region of the lipopolysaccharide , which might be present in rabbit plasma , probably did not play a prominent role in the complement-mediated lytic response . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
94,
101
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
116,
134
]
} |
also , rabbit antisera were prepared to the epstein-bar virus nuclear antigen ( ebna ) and the early antigen ( ea ) and utilized in an indirect immunofluorescence test ( iit ) to detect these antigens in human lymphocytes isolated from various disease states . | NA | {
"id": "C0003342",
"name": "virus",
"pos": [
56,
61
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
192,
199
]
} |
however , patients with lymphoproliferative disorders , including hodgkin 's disease , harbored in their spleens and lymph nodes lymphocytes producing both ebna and ea . | NA | {
"id": "C0003342",
"name": "ebna",
"pos": [
156,
160
]
} | {
"id": "C0003320",
"name": "ea",
"pos": [
165,
167
]
} |
however , a single dose as small as 5 mg/kg caused a temporary but significant reduction in the formation of 4-aminoantipyrine from aminophenazone ( oxidative demethylation ) , where the renal excretion of 4-aminoantipyrine provided a measure of the decrease . | NA | {
"id": "C0002586",
"name": "aminophenazone",
"pos": [
132,
146
]
} | {
"id": "C0002696",
"name": "aminoantipyrine",
"pos": [
208,
223
]
} |
the concentration of lithium was determined in plasma , cerebrospinal fluid ( csf ) and bile in two groups of 5 and 6 patients after oral administration of lithium carbonate ( 0.2 mval/kg b.w . ) in each group . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
21,
28
]
} | {
"id": "C0085217",
"name": "lithium",
"pos": [
156,
163
]
} |
if human red cells are incubated with either noradrenaline or isoprenaline , these catecholamines are adsorbed to the cells surface first in a fast reaction . | NA | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
62,
74
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
83,
97
]
} |
by use of enzyme cytochemistry , fluorescence microscopy , and lipid extraction two types of melanin-containing complex granules were identified : melanin with a cortex of lipofuscin ( melanolipofuscin ) and melanin with a cortex of nonlipid , enzyme reactive material ( melanolysosomes ) . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
63,
68
]
} | {
"id": "C0023789",
"name": "lipofuscin",
"pos": [
191,
201
]
} |
the degree of dna inhibition was correlated with the induction of the ebv-determined antigens ( membrane , early , and nuclear antigens ) in sensitive indicator cells . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
85,
93
]
} | {
"id": "C0069115",
"name": "nuclear",
"pos": [
119,
126
]
} |
the measurement was made in the third trimester of pregnancy in 30 women with pathological pregnancies and in 51 pregnant control subjects . | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
32,
47
]
} | {
"id": "C0032961",
"name": "women",
"pos": [
67,
72
]
} |
inert gas flux across the skin of yorkshire piglets anesthetized with pentobarbital was measured for he , ne , ch4 , c2h4 , n2o , and sf6 . | NA | {
"id": "C0017112",
"name": "inert gas",
"pos": [
0,
9
]
} | {
"id": "C0018880",
"name": "he",
"pos": [
101,
103
]
} |
1-n hapa gentamicin b , a new aminoglycoside active against gentamicin resistant isolates -- activity compared to other aminoglycosides . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
9,
19
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
120,
135
]
} |
the results of this study supported the theoretical explanation of two pain mechanisms involved in combined muscle contraction-migraine headaches as well as the effectiveness of bio-feedback procedures that target directly the specific pain mechanism in the elimination of the two types of head pain . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
71,
75
]
} | {
"id": "C0018681",
"name": "pain",
"pos": [
295,
299
]
} |
however , application of membrane-interacting agents like tris ( hydroxymethyl ) aminomethane ( tris ) -hydrochloride , ethylenediaminetetraacetate ( na salt ) ( edta ) , divalent cations , and sublethal doses of the cationic antibacterial agents polymyxin b and chlorhexidine induced specific fluorescent labeling of envelope proteins and lipids but not of cytoplasmic compounds , with the exception of a soluble protein with a molecular weight of 46,000 in sodium dodecyl sulfate-polyacrylamide gel electrophoresis . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
171,
187
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
217,
225
]
} |
the results are discussed with regard to a possible localization of labeled and unlabeled compounds of the cell envelope on the basis of a model placing cell envelope amino groups into ion-ion interactions with anionic components of other envelope compounds like phosphate and carboxyl groups . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
61,
64
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
211,
218
]
} |
the results are discussed with regard to a possible localization of labeled and unlabeled compounds of the cell envelope on the basis of a model placing cell envelope amino groups into ion-ion interactions with anionic components of other envelope compounds like phosphate and carboxyl groups . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
211,
218
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
263,
272
]
} |
alcohol-oxidizing enzymes of the facultative methylotroph par were investigated after growth of the bacteria on methanol and ethanol . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
112,
120
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
125,
132
]
} |
the contribution of the carbohydrate moiety to the cd and ord spectra was estimated on the basis of data obtained from isolated glycopeptides and the constituent monosaccharides . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
24,
36
]
} | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
162,
177
]
} |
serine protease from rat liver formed a single immunoprecipitation band against antiserum to purified protease from hepatoma 8999 . | NA | {
"id": "C0036734",
"name": "serine",
"pos": [
0,
6
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
102,
110
]
} |
after calcium-gel treatment of the crude enzyme extract , ammonium sulfate precipitation , and removal of polynucleotides with deae-cellulose , the enzyme was nonspecifically adsorbed onto phosphocellulose ( p-cellulose ) , and then eluted specifically with a linear concentration gradient of threonine trna from torula yeast ( candida ( torulopsis ) utilis ) . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
127,
141
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
210,
219
]
} |
these results suggest that chloramphenicol traps aminoacyl-trna at the a-sites of ribosomes by damming-up the small flow of aminoacyl-trna under the restrictive supply of amino acids . | NA | {
"id": "C0035714",
"name": "aminoacyl-trna",
"pos": [
49,
63
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
171,
182
]
} |
the ca2+ , mg2+-atpase with oxalate , so-called `` '' extra atpase , '' '' showed the same response to the ions as did the activity without oxalate during storage . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
11,
14
]
} | {
"id": "C0001473",
"name": "atpas",
"pos": [
16,
21
]
} |
although growth of this phage was markedly inhibited even at 35-37 degrees c even in dna+ host , conversion of the infecting single-stranded dna into the double-stranded parental replicative form ( stage i synthesis ) occurred normally at 43 degrees c in dna+ , dnaa , dnab , dnac ( d ) , and dnae cells . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
125,
144
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
293,
296
]
} |
the assay can be done in the presence of large amounts of contaminating amino acid , protein and/or exopeptidases which may interfere with the ordinary assay of proteinases . | NA | {
"id": "C0117059",
"name": "exopeptidases",
"pos": [
100,
113
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
161,
172
]
} |
transglutaminases were found to catalyze the formation of cross-links between peptide chains by means of a transfer reaction between the carboxamide group of a glutamine residue in each chain and both primary amino groups of a diamine or a polyamine . | NA | {
"id": "C0011957",
"name": "diamine",
"pos": [
227,
234
]
} | {
"id": "C0032433",
"name": "polyamine",
"pos": [
240,
249
]
} |
production of this heretofore undescribed linkage by guinea pig liver transglutaminase was demonstrated by the use of high performance liquid chromatography in a model system using glutamine peptide derivatives and a variety of diamines and polyamines . | NA | {
"id": "C0011957",
"name": "diamines",
"pos": [
228,
236
]
} | {
"id": "C0032433",
"name": "polyamines",
"pos": [
241,
251
]
} |
the modified species were tested as substrates for activation by their cognate aminoacyl-trna synthetases and for misacylation with phenylalanine by yeast phenylalanyl-trna synthetase . | NA | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
79,
105
]
} | {
"id": "C0031460",
"name": "phenylalanyl-trna synthetase",
"pos": [
155,
183
]
} |
flotation rates of vldl subspecies from hypertriglyceridemic and normolipemic plasmas correlated directly with their stokes radii and triglyceride content and inversely with their proportion of cholesterol , cholesteryl esters , phospholipids , and total protein . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
194,
205
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
208,
226
]
} |
in contrast , base analogs that have alterations that appear in the major groove of the dna helix , such as uracil , 5-bromouracil , 5-methylcytosine , 5-hydroxymethylcytosine , and [ 5-hgsr ] pyrimidines , do not prevent utilization of the promoter . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
108,
114
]
} | {
"id": "C0006242",
"name": "5-bromouracil",
"pos": [
117,
130
]
} |
( - ) -isoproterenol has an apparent ki of 2 nm , ( - ) -epinephrine is 1.5 to 3 times weaker , and ( - ) -norepinephrine is 30 to 60 times weaker . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
57,
68
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
107,
121
]
} |
at the intraspecies level , the alpha-subunits of human fsh , human luteinizing hormone , and human chorionic gonadotropin are similar , whereas at the interspecies level there are differences among the alpha-subunits of fsh , luteinizing hormone , and thyroid-stimulating hormone . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
94,
122
]
} | {
"id": "C0017963",
"name": "alpha-subunits",
"pos": [
203,
217
]
} |
by the addition of radioactively labeled hemin and by the analysis of the radioactive heme in hemoglobin , only 60 to 70 % of heme in the newly synthesized hemoglobin was accounted for by the exogenously added hemin . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
86,
90
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
210,
215
]
} |
in keeping with this finding , hemin treatment increased the activity of two enzymes in the heme biosynthetic activity , i.e . delta-aminolevulinate ( ala ) dehydratase and uroporphyrinogen-i ( uro ) synthase in these cells . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
31,
36
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
92,
96
]
} |
incorporation of [ 2 ( -14c ) ] glycine , [ 14c ] ala , and 59fe into heme was also significantly increased in the cells treated with hemin , suggesting that essentially all enzyme activities in the heme biosynethetic pathway were increased after hemin treatment . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
70,
74
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
247,
252
]
} |
these results indicate that heme in the newly synthesized hemoglobin in hemin-treated friend cells derives both from hemin added to the culture and from heme synthesized intracellularly . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
72,
77
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
153,
157
]
} |
in addition , these results suggest that the stimulation of heme biosynthesis by hemin in friend virus-transformed cells is in contrast to the hemin repression of heme biosynthesis in liver cells . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
60,
64
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
143,
148
]
} |
the alpha-keto acid analogs of arginine and citrulline ( and of their next higher homologs , homoarginine and homocitrulline ) were prepared enzymatically and shown to exist in equilibrium with cyclic forms which predominate in solution and in the solid state . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
31,
39
]
} | {
"id": "C0019877",
"name": "homoarginine",
"pos": [
93,
105
]
} |
the cyclic forms of the alpha-keto acid analogs of arginine and homoarginine have the structures pyrrolidine-1-amidino-2-hydroxy-2-carboxylic acid and piperidine-1-amidino-2-hydroxy-2-carboxylic acid , respectively . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
51,
59
]
} | {
"id": "C0019877",
"name": "homoarginine",
"pos": [
64,
76
]
} |
cyclic amp efflux was measured following hormonal stimulation of adenylate cyclase in a variety of animal cells including c-6 rat glioma cells , wi-38 human fibroblasts , and avian erythrocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
106,
111
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
157,
168
]
} |
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