text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
after sodium bicarbonate-loading , however , there was no difference between intact and tptx high-phosphorus animals because bicarbonate inhibited pi reabsorption extensively in both . | NA | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
6,
24
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
125,
136
]
} |
the isolation of an abnormal lipoprotein ( lipoprotein-x ; lp-x ) from the plasma of cholestatic patients was achieved by a combination of various physico-chemical techniques . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
29,
40
]
} | {
"id": "C0023819",
"name": "lp-x",
"pos": [
59,
63
]
} |
the high specificity and power of the lp-x test as clinical-chemical parameter to demonstrate or exclude cholestasis finds its explanation in our knowledge about the origin of this abnormal lipoprotein in cholestasis . | NA | {
"id": "C0023819",
"name": "lp-x",
"pos": [
38,
42
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
190,
201
]
} |
lp-x is formed when a lipoprotein normally excreted with the bile refluxes into the plasma stream to convert into lp-x . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
22,
33
]
} | {
"id": "C0023819",
"name": "lp-x",
"pos": [
114,
118
]
} |
the effects of beta-adrenergic agonists such as isoproterenol , norepinephrine and epinephrine upon the adenylate cyclase activity of human fat cell ghosts were tested , each alone and in combination with the beta-blocking agent propranolol . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
64,
78
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
83,
94
]
} |
the reliability of the angiotensin ii ( at ii ) -antagonist saralasin in the diagnosis of at ii-dependent forms of hypertension was investigated in 61 cases of hypertension of different etiology . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
60,
69
]
} | {
"id": "C0003009",
"name": "at ii",
"pos": [
90,
95
]
} |
in 14 patients , lowering of blood pressure by saralasin suggested an at ii-dependent hypertension which could be ascertained in 8 patients ( 5 had undergone successful surgery ) by increased levels of plasma-renin-activity ( pra ) , at ii , pra-ratio in renal vein blood and by angiography . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
47,
56
]
} | {
"id": "C0003009",
"name": "at ii",
"pos": [
234,
239
]
} |
besides , depressor reactions by saralasin yielded additional information in three patients with renovascular hypertension but normal levels of pra and at ii , in two patients with high renin essential hypertension and one patient with pheochromocytoma . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
33,
42
]
} | {
"id": "C0003009",
"name": "at ii",
"pos": [
152,
157
]
} |
active transport of alanine after incorporation of the alanine carrier into reconstituted proteoliposomes was driven not only by an artificial membrane potential generated by potassium ion diffusion via valinomycin but also by mitochondrial cytochrome oxidase incorporated into the same liposomes and supplemented with both cytochrome c and ascorbic acid . | NA | {
"id": "C0025256",
"name": "artificial membrane",
"pos": [
132,
151
]
} | {
"id": "C0023828",
"name": "liposomes",
"pos": [
287,
296
]
} |
the biosynthetic abilities of wi-38 fibroblasts from early and late population-doubling-level cultures were compared by autoradiography of cells grown with labeled precursors of dna , rna , protein and lipids . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
36,
47
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
139,
144
]
} |
in view of the peculiarities of the clinico-pathological syndrome presented by these patients , the authors raise the questions does it represent a special modality of l.e.d . or a new lupus-like disease ? | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
57,
65
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
196,
203
]
} |
influence of lipid concentrations and age on transfer of plasma lipoprotein into human arterial intima . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
13,
18
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
64,
75
]
} |
in investigations on the action of dkb ( 3 ' 4'-dideoxykanamycin b ) , and aminoglycoside type drug , on the inner ears of mice and guinea pigs by means of scanning and transmission electron microscopy , it was evident that the action of dkb against the inner ear is similar to that of kanamycin . | NA | {
"id": "C0012024",
"name": "dkb",
"pos": [
35,
38
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
286,
295
]
} |
these products , as well as the disaccharides sucrose and lactose , undergo enzymatic hydrolysis to monosaccharides at the brush border surface . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
32,
45
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
46,
53
]
} |
isolation and characterization of ( + ) -cannabitriol and ( - ) -10-ethoxy-9-hydroxy-delta 6a [ 10a ] -tetrahydrocannabinol : two new cannabinoids from cannabis sativa l. extract . | NA | {
"id": "C0039663",
"name": "tetrahydrocannabinol",
"pos": [
103,
123
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
134,
146
]
} |
it was concluded that the decrease in the capacity to synthesize glycerides , rather than limiting substrate concentrations , could be the cause of the decrease in the lipid content in some tissues of the cardiomyopathic hamster . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
65,
75
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
168,
173
]
} |
diester waxes from skin lipids of the feet of biotin depleted and biotin supplemented turkey poults . | NA | {
"id": "C0043076",
"name": "waxes",
"pos": [
8,
13
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
24,
30
]
} |
the neutral lipids of the skin from the feet of turkey poults fed a biotin supplemented or a biotin deficient diet consist mainly of triacyglycerols , and of mono- and diester waxes . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
12,
18
]
} | {
"id": "C0043076",
"name": "waxes",
"pos": [
176,
181
]
} |
effects of a single ingestion of sodium taurocholate on esterified cholesterol concentration in liver and cholesterol turnover in the rat . | NA | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
56,
78
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
106,
117
]
} |
no statistically significant differences were observed between the two isoproterenol treated groups for severity of the induced lesions , changes in heart weight , or heart weight to body weight ratios . | NA | {
"id": "C0005911",
"name": "changes in",
"pos": [
138,
148
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
188,
194
]
} |
in normals fasting resulted in a significant decrease of the blood glucose response to insulin injection , whereas in fasting obese subjects glucose response was unchanged . | NA | {
"id": "C0005802",
"name": "in",
"pos": [
0,
2
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
141,
148
]
} |
this protein remains near the origin upon electrophoresis in polyacrylamide gels containing sodium dodecyl sulfate , has beta electrophoretic mobility in agarose gel , is insoluble in tetramethylurea , and precipitates with antisera to the b-apoprotein isolated from low-density lipoprotein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
5,
12
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
242,
252
]
} |
the induction of cellulase by lactose is regarded as a derepression of the synthesis of this enzyme as a result of slow assimilation of the disaccharide . | NA | {
"id": "C0022949",
"name": "lactose",
"pos": [
30,
37
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
140,
152
]
} |
this form of subtilisin may be the primary product of translation of the structural gene and therefore a precursor of subtilisin . | NA | {
"id": "C0038601",
"name": "subtilisin",
"pos": [
13,
23
]
} | {
"id": "C0038597",
"name": "a",
"pos": [
103,
104
]
} |
the activity of the enzyme is inhibited by fad but not by fmn and riboflavin . | NA | {
"id": "C0016388",
"name": "fmn",
"pos": [
58,
61
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
66,
76
]
} |
in three cases of established cranial diabetes insipidus , the effectiveness of the new vasopressin analogue 1-desamino-8-d-arginine vasopressin ( ddavp ) in controlling diabetes insipidus is demonstrated . | NA | {
"id": "C0687720",
"name": "cranial diabetes insipidus",
"pos": [
30,
56
]
} | {
"id": "C0011848",
"name": "diabetes insipidus",
"pos": [
170,
188
]
} |
sixty subjects participated in a double-blind study comparing methadyl acetate ( 80 mg ) with two dosages of methadone ( 50 mg and 100 mg ) in the maintenance of opiate addicts . | NA | {
"id": "C0025607",
"name": "methadyl acetate",
"pos": [
62,
78
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
109,
118
]
} |
the safety of all three regimens was supported and methadyl acetate was as effective as methadone in the retention of subjects . | NA | {
"id": "C0025607",
"name": "methadyl",
"pos": [
51,
59
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
88,
97
]
} |
coli ribosomal 16s rna prepared by an acetic acid-urea extraction technique individually binds , in addition to the seven established proteins , 6 new 30s ribosomal proteins ( s3 , s5 , s9 , s12 , s18 and s11 ) ( hochkeppel et al. , 1976 ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
134,
142
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
155,
173
]
} |
bacterial proteins coded by lambdafira transducing phages have been examined after infection of a uv-irradiated lambda lysogen , and 2 major fir-specific proteins have been characterized . | NA | {
"id": "C0004627",
"name": "bacterial proteins",
"pos": [
0,
18
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
154,
162
]
} |
several thousand mutagenized clones of escherichia coli were screened for methyl group incorporation into protein in crude extracts , in order to isolate mutants lacking the full complement of methyl groups in ribosomal proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
106,
113
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
210,
228
]
} |
low passaged colon and rectal carcinoma cells , hct-8 and hrt-18 , as well as normal rectal , colon and foreskin fibroblasts were positive for fibrinolytic activity , while long established ( greater than 100 passages ) cultures of malignant cells ( colon carcinoma , hela , hep-2 , kb ) as well as normal cells ( hei , av3 ) were negative . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
113,
124
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
299,
305
]
} |
hypoglycemia was accepted as the correct diagnosis in 72 cases ( group i ) , where 2 or more blood sugar values or at least one blood sugar value and one glucose value in the cerebrospinal fluid were below the limit for the age-group . | NA | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
93,
104
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
154,
161
]
} |
the clastogenic effect of furocoumarins psoralen and angelicin in the presence of near-uv ( 320-380 nm ) differs greatly , as do their modes of interaction with dna . | NA | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
26,
39
]
} | {
"id": "C0016072",
"name": "psoralen",
"pos": [
40,
48
]
} |
effect of ph on the tolerance of penicillium nigricans to copper and other heavy metals . | NA | {
"id": "C0009968",
"name": "copper",
"pos": [
58,
64
]
} | {
"id": "C0347988",
"name": "heavy",
"pos": [
75,
80
]
} |
analyses of survival taking into account other important prognostic variables establish that the presence of complex premature beats ( r on t , runs of 2 or more , multiform or bigeminal premature beats ) in the monitoring hour is associated with a risk of sudden coronary death three times that of the men free of complex ventricular premature beats . | NA | {
"id": "C0340464",
"name": "premature beats",
"pos": [
117,
132
]
} | {
"id": "C0151636",
"name": "ventricular",
"pos": [
323,
334
]
} |
the formation of insoluble complexes of sunflower seed albumin and alginate or pectin is studied by means of turbidimetric titration and by determining the ph-dependent precipitability of protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
55,
62
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
188,
195
]
} |
the results obtained by turbidimetric titration of model systems can , in principle , be extrapolated to the precipitation of albumins from protein extracts . | NA | {
"id": "C0001924",
"name": "albumins",
"pos": [
126,
134
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
140,
147
]
} |
in accordance with the heterogenicity of the protein , the turbidimetric titration of the albumin-alginate and the albumin-pectin complexes exhibits two maxima . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
45,
52
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
115,
122
]
} |
a comparison of the amount of heavy metals taken up by an average smoker ( at most 20 cigarettes per day ) with the mac values adopted in the gdr conveys the impression that the loading with copper , lead and zinc is unimportant , whereas , according to the findings of other authors , the loading with cadmium is but seemingly insignificant . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
30,
42
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
191,
197
]
} |
a comparison of the amount of heavy metals taken up by an average smoker ( at most 20 cigarettes per day ) with the mac values adopted in the gdr conveys the impression that the loading with copper , lead and zinc is unimportant , whereas , according to the findings of other authors , the loading with cadmium is but seemingly insignificant . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
30,
42
]
} | {
"id": "C0023175",
"name": "lead",
"pos": [
200,
204
]
} |
a comparison of the amount of heavy metals taken up by an average smoker ( at most 20 cigarettes per day ) with the mac values adopted in the gdr conveys the impression that the loading with copper , lead and zinc is unimportant , whereas , according to the findings of other authors , the loading with cadmium is but seemingly insignificant . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
30,
42
]
} | {
"id": "C0043481",
"name": "zinc",
"pos": [
209,
213
]
} |
a comparison of the amount of heavy metals taken up by an average smoker ( at most 20 cigarettes per day ) with the mac values adopted in the gdr conveys the impression that the loading with copper , lead and zinc is unimportant , whereas , according to the findings of other authors , the loading with cadmium is but seemingly insignificant . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
30,
42
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
303,
310
]
} |
concentrations and specific radioactivities of choline , acetylcholine , phosphorylcholine , lipid choline , and sn-glycero-3-phosphorylcholine after i.v . injection of methyl-14c-choline were measured in the brain of untreated controls and of rats anesthesized with urethane . | NA | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
73,
90
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
180,
187
]
} |
the specific activity was found to be decreased during deep anesthesia by 40 % in acetylcholine , 20-30 % in phosphorylcholine , 50-75 % in lipid choline , and 30-40 % in sn-glycero-3-phosphoryl-choline . | NA | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
109,
126
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
195,
202
]
} |
chromatographic fractions , assumed to contain tumor specific antigens , antibodies or antigen-antibody complexes were identified by their absorption capacity upon specially prepared syngeneic immune sera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
73,
83
]
} | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
87,
113
]
} |
chromatographic fractions , assumed to contain tumor specific antigens , antibodies or antigen-antibody complexes were identified by their absorption capacity upon specially prepared syngeneic immune sera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
73,
83
]
} | {
"id": "C0020960",
"name": "immune sera",
"pos": [
193,
204
]
} |
free antibody and antigen-antibody complexes , accompanied with a weak cell mediated immunity ( cmi ) were correlated with efficient cti in 2 -- 3 % tw/tbw tumor bearers . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
5,
13
]
} | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
18,
44
]
} |
high levels of free antigen and antigen-antibody complexes , lack of antibodies and cmi were correlated with cti absence in huge tumor bearers , representing 30 -- 37 % of total body weight . | NA | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
32,
58
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
69,
79
]
} |
streptokinase euglobulin lysis time ( sk-elk ) , fibrin and fibrinogen degradation products ( fdp ) and fibrinogen in the blood were determined to know the proper dosage of t-amcha which would not cause the ischemic complications yet suffice to prevent the rebleeding of ruptured intracranial aneurysm . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
49,
55
]
} | {
"id": "C0163275",
"name": "fibrinogen degradation",
"pos": [
60,
82
]
} |
trh administration of prolactin ( prl ) and thyrotropin stimulating hormone ( tsh ) serum levels was studied in order to verify the existence of a ventricular route in man for releasing factor delivery to the anterior pituitary , which has been previously reported in rats . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
44,
55
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
209,
227
]
} |
when premidication is needed or when convulsions occur after amipaque examinations , combined diazepam and phenobarbital therapy ought to be instituted in order to achieve the best control of epileptic reactions . | NA | {
"id": "C0036572",
"name": "convulsions",
"pos": [
37,
48
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
192,
201
]
} |
effect of elevated extracellular potassium on the release of labelled noradrenaline , glutamate , glycine , beta-alanine and other amino acids from rat brain cortex slices . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
98,
105
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
131,
142
]
} |
within the prenatal group , no less than 43 per cent presented firm evidence favouring a genetic etiology , chromosomal syndromes together constituting 36 per cent and mutant gene disorders 7 per cent . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
120,
129
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
180,
189
]
} |
male rats were starved and refed diets containing 40 % disaccharides ( maltose , trehalose , sucrose , turanose ) , trisaccharide ( melezitose ) , starch , or the monosaccharide equivalents . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
55,
68
]
} | {
"id": "C0024658",
"name": "maltose",
"pos": [
71,
78
]
} |
male rats were starved and refed diets containing 40 % disaccharides ( maltose , trehalose , sucrose , turanose ) , trisaccharide ( melezitose ) , starch , or the monosaccharide equivalents . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
55,
68
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
93,
100
]
} |
maltose , trehalose , sucrose , and turanose refeeding resulted in g6pd and me responses which were higher than the responses to their component monosaccharides ( disaccharide effect ) . | NA | {
"id": "C0024658",
"name": "maltose",
"pos": [
0,
7
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
163,
175
]
} |
maltose , trehalose , sucrose , and turanose refeeding resulted in g6pd and me responses which were higher than the responses to their component monosaccharides ( disaccharide effect ) . | NA | {
"id": "C0040815",
"name": "trehalose",
"pos": [
10,
19
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
163,
175
]
} |
maltose , trehalose , sucrose , and turanose refeeding resulted in g6pd and me responses which were higher than the responses to their component monosaccharides ( disaccharide effect ) . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
22,
29
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
163,
175
]
} |
the fractional elimination rate of fat emulsions of soybean oil , emulsified with egg yolk phosphatides with 1 % addition of cholesterol or various cholesteryl fatty acid esters , was studied in rabbits . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
125,
136
]
} | {
"id": "C0008387",
"name": "cholesteryl",
"pos": [
148,
159
]
} |
addition of saturated cholesteryl esters did not affect the lipase activity , but addition of 1 % cholesterol markedly decreased the lipase activity . | NA | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
22,
40
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
98,
109
]
} |
preventability -- the presence or absence of avoidable factors which might have materially lessened the risk of death -- was determined for each perinatal death . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
112,
117
]
} | {
"id": "C0701826",
"name": "perinatal death",
"pos": [
145,
160
]
} |
based on this hypothesis a therapeutic trial with flufenamic acid ( a prostaglandin inhibitor of the fenamates group ) was conducted during 1 year in 5 patients suffering from recurrent ophthalmoplegic migraine . | NA | {
"id": "C0016282",
"name": "flufenamic acid",
"pos": [
50,
65
]
} | {
"id": "C1955898",
"name": "fenamates",
"pos": [
101,
110
]
} |
the conversion of glycine into amino acids on heating at 240 degrees c with basic manganous carbonate and alumina is investigated . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
18,
25
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
31,
42
]
} |
hb a containing erythrocytes of the adult can be distinguished from mainly hb f containing erythrocytes of the newborn by means of the kleihauer staining method . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
0,
2
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
75,
79
]
} |
the ratio of the red blood cell volume of the donor to that of the patient is represented by the ratio of hb a to hb f containing erythrocytes . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
106,
108
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
114,
118
]
} |
corticosterone , cortisol and alodosterone are corticosteroid hormones while dehydrocorticosterone is a product of a metabolic transformation of corticosterone . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
47,
61
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
62,
70
]
} |
it seems likely that the presence of corticosteroid hormones in tissues of a. suum is indicative of their participation in the metabolism of the latter . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
37,
51
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
52,
60
]
} |
persistent fetal circulation : an evolving clinical and radiographic concept of pulmonary hypertension of the newborn . | NA | {
"id": "C0031190",
"name": "persistent fetal circulation",
"pos": [
0,
28
]
} | {
"id": "C0020542",
"name": "pulmonary hypertension",
"pos": [
80,
102
]
} |
all native closed circular dnas examined , including the viral and intracellular forms of sv40 and polyoma dna , bacterial plasmid dnas , and the double stranded closed circular dna genome of the marine bacteriophage , pm2 , are more heterogeneous with respect to the number of superhelical turns present than are the thermal distributions observed in the limit products of the action of nicking-closing ( n-c ) enzyme on the respective dnas . | NA | {
"id": "C0012924",
"name": "bacterial",
"pos": [
113,
122
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
437,
441
]
} |
all native closed circular dnas examined , including the viral and intracellular forms of sv40 and polyoma dna , bacterial plasmid dnas , and the double stranded closed circular dna genome of the marine bacteriophage , pm2 , are more heterogeneous with respect to the number of superhelical turns present than are the thermal distributions observed in the limit products of the action of nicking-closing ( n-c ) enzyme on the respective dnas . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
18,
30
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
437,
441
]
} |
there is a temperature range in which dna : dna rates are negligible and rna : dna rates close to optimal . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
9,
10
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
79,
82
]
} |
the extent of shared sequences was studied by reassociating a labeled preparation of short repetitive dna with an excess of unlabeled long repetitive dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
16,
17
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
150,
153
]
} |
it is shown by melting profile analysis of lac repressor-dna complexes that repressor binds tightly and preferentially ( relative to single-stranded dna ) to double-stranded non-operator dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
133,
152
]
} | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
158,
173
]
} |
the nucleotide sequence of a particular t1 oligonucleotide found in 41s and 28s rnas of several cellular cell lines ( human , mouse , rat and chicken fibroblast ) but absent in 45s ribosomal rna has been deduced . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
96,
100
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
150,
160
]
} |
by analysis with agarose gel electrophoresis and direct examination with dark field electron microscopy , we found that a large amount of the single-nicked circular dna ( form ii ) was produced before the linear sv40 dna ( form iii ) appeared . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
156,
168
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
217,
220
]
} |
the dna remains chemically unaltered after exposure to rbtca as shown by the absence of strand scissions for closed circular dna and by the unimpaired biological activity in transformation assays . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
4,
7
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
116,
128
]
} |
5 ' phosphorylation in vitro with gamma-32p-atp and t4 phage induced polynucleotide kinase was used to obtain rnaase a and rnaase t1 fingerprints of three plant viroids : potato spindle tuber viroid from tomato ( pstv-tom ) , chrysanthemum stunt viroid from cineraria ( chsv-cin ) and citrus exocortis viroid from gynura aurantiaca ( cev-gyn ) . | NA | {
"id": "C0014241",
"name": "rnaase",
"pos": [
110,
116
]
} | {
"id": "C0018364",
"name": "rnaase t1",
"pos": [
123,
132
]
} |
alpha-lactalbumin messenger rna was partially purified from rna extracted from 3-5 day lactating rat mammary glands on a poly ( u ) -sepharose column followed by sucrose gradient centrifugation . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
18,
31
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
60,
63
]
} |
the reaction is hindered by substitution at c-5 with the greatest effect shown in pseudouridine ( r = ribosy1 ) and the least in uridine ( r = h ) . | NA | {
"id": "C0033846",
"name": "pseudouridine",
"pos": [
82,
95
]
} | {
"id": "C0041984",
"name": "uridine",
"pos": [
129,
136
]
} |
it contained besides small amounts of fragmented bulk dna , single-stranded nascent dna and single-stranded pre-labelled dna which could be separated from each other by using brdu as a density label . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
60,
75
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
121,
124
]
} |
half of the cases with cysts and necroses showed an inhomogeneity in the uptake by the tumor . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
23,
28
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
87,
92
]
} |
site specificity of the enzymatic cleavage examined by identifying the 5'-terminal nucleotides in cleaved adenovirus-2 dna and by studies with synthetic polynucleotides of defined sequence , indicates that the initial endonucleolytic cleavage occurs at a site containing a deoxythymidine residue . | NA | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
83,
94
]
} | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
153,
168
]
} |
the 7-methylguanylic acid residue confronting the 5'-terminal nucleotide of mrna through two pyrophosphate linkages was completely removed by tobacco pyrophosphatase from mrnas of cytoplasmic polyhedrosis virus , tobacco mosaic virus ( viral rna ) , and globin without any scission in the inner part of the rna chain . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
236,
245
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
307,
310
]
} |
the importance of arginine residues 13 and 14 in the bee venom neurotoxin , apamin , was teste by the synthesis of replacement analogs . | NA | {
"id": "C0004920",
"name": "bee venom",
"pos": [
53,
62
]
} | {
"id": "C0003521",
"name": "apamin",
"pos": [
76,
82
]
} |
incubation of normal and transformed fibroblasts with these antitubulins led to the disappearance of nonactive cell edges ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
37,
48
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
111,
115
]
} |
glucocorticoid-stimulated accumulation of mouse mammary tumor virus rna : increased rate of synthesis of viral rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
68,
71
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
105,
114
]
} |
in gr cells the hormone causes a 10-fold increase in the rate of synthesis of viral rna without appreciably affecting the overall rate of cellular rna synthesis . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
78,
87
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
147,
150
]
} |
the in vitro regulation of fetal hemoglobin ( hbf was investigated in clones of cultured adult human erythroid cells by in situ immunofluorescent identification of the hemoglobins synthesized . | NA | {
"id": "C0015936",
"name": "hbf",
"pos": [
46,
49
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
168,
179
]
} |
radioactive proline-labeled procollagen , accumulated during a 3-hr incubation of normal and transformed balb 3t3 cultures , was treated with pepsin and the resulting collagen components were analyzed by carboxymethyl-cellulose chromatography and sodium dodecyl sulfate/polyacrylamide gel electrophoresis in the presence or absence of reducing agent . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
28,
39
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
167,
175
]
} |
the human hypoxanthine phosphoribosyl-transferase ( imp : pyrophosphate phosphoribosyltransferase , ec 2.4.2.8 ) gene ( hprt ) has been serially transferred to mouse cells and then to chinese hamster fibroblasts by two cycles of metaphase chromosome isolation and incubation with recipient cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
200,
211
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
290,
295
]
} |
detection of active heteropolymeric beta-glucuronidase in hybrids between mouse cells and human fibroblasts with beta-glucuronidase deficiency . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
80,
85
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
96,
107
]
} |
heteropolymeric beta-glucuronidases are detected in somatic cell hybrids between mouse cells and human fibroblasts deficient in beta-glucuronidase ( beta-d-glucuronide glucuronosohydrolase , ec 3.2.1.31 ) by electrophoresis and column chromatography . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
87,
92
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
103,
114
]
} |
in contrast , adult thymectomized animals , when challenged with adjuvant and allogeneic cells , had a normal cytotoxic response in vivo and their cells could not inhibit the generation of cytotoxic t cells in vitro . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
78,
94
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
201,
206
]
} |
t-cell-mediated lysis of h-2 compatible target cells infected with the strain of virus used to immunize the mice was considerably higher than lysis of either syngeneic cells infected with a different strain of influenza virus or allogeneic cells infected with the immunizing strain of influenza virus . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
47,
52
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
229,
245
]
} |
double-antibody immunoprecipitation procedures with antisera to endorphins and to corticotropin ( acth ) were used to study the biosynthesis of these peptides in a mouse pituitary tumor cell line . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
7,
15
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
52,
60
]
} |
in the cytoplasm of well-spread cultured normal fibroblasts , actin is organized into a network of cables that run the length of the cell just inside the adherent cell membrane . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
48,
59
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
150,
153
]
} |
isoantigenic expression of forssman glycolipid in human gastric and colonic mucosa : its possible identity with `` '' a-like antigen '' '' in human cancer . | NA | {
"id": "C0022145",
"name": "isoantigenic",
"pos": [
0,
12
]
} | {
"id": "C0003320",
"name": "antige",
"pos": [
3,
9
]
} |
two components -- one resembling intact cholecystokinin in size and charge and immunologic specificity , and the other resembling the cooh-terminal octapeptide of cholecystokinin -- have been found in extracts of the pig cerebral cortex . | NA | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
40,
55
]
} | {
"id": "C0037167",
"name": "octapeptide",
"pos": [
148,
159
]
} |
blood glucose profiles in man after ingestion of different loadings of glucose and glucose/fructose mixtures . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
0,
13
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
83,
90
]
} |
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