text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
this portion of the molecule , about 27 % of the protein , contains over 40 % of the lysine and tyrosine residues and has a slight excess of basic amino acids . | NA | {
"id": "C0024337",
"name": "lysine",
"pos": [
85,
91
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
141,
158
]
} |
the amount of zinc incorporated into viral proteins was affected by the absence of various t4d gene products . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
37,
51
]
} | {
"id": "C0033684",
"name": "gene products",
"pos": [
95,
108
]
} |
cells infected with t4d 12- , and to a much less extent those infected with t4d 29- , incorporated the least amount of zinc into proteins , while cells infected with t4d 11- and t4d 51- incorporated increased amounts of zinc into the zinc metalloproteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
129,
137
]
} | {
"id": "C0025544",
"name": "metalloproteins",
"pos": [
239,
254
]
} |
the marked effect of infection of e. coli with t4d 12- on both zinc uptake and zinc incorporation into protein supports the conclusion that t4d gene 12 protein is a zinc metalloprotein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
103,
110
]
} | {
"id": "C0025544",
"name": "metalloprotein",
"pos": [
170,
184
]
} |
certain cells such as cho ( chinese hamster ovary ) and fibroblasts attach to a substrate of type i collagen via proteins that link the cell surface to collagen . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
56,
67
]
} | {
"id": "C0007634",
"name": "the cell",
"pos": [
132,
140
]
} |
the conformation of clq in buffered saline solutions at ph 7.4 or 6.0 did not differ significantly from clq at twice the saline concentration as determined with circular dichroism , difference spectroscopy , and tritium-hydrogen exchange techniques . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
212,
219
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
220,
228
]
} |
these results indicate the two bands represent either two different molecular weight forms of the enzyme or two differently charged isoenzymes . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
98,
104
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
132,
142
]
} |
the evaluation of the efficiency of polymer additives with special emphasis on uv absorbers and antioxidants in polyurethane elastomers has been completed . | NA | {
"id": "C0032521",
"name": "polymer",
"pos": [
36,
43
]
} | {
"id": "C0013766",
"name": "elastomers",
"pos": [
125,
135
]
} |
the evaluation of the efficiency of polymer additives with special emphasis on uv absorbers and antioxidants in polyurethane elastomers has been completed . | NA | {
"id": "C0032616",
"name": "polyurethane",
"pos": [
112,
124
]
} | {
"id": "C0013766",
"name": "elastomers",
"pos": [
125,
135
]
} |
the polyurethane elastomers were either synthesized by ourselves or formulated according to the manufacturer 's recommendation . | NA | {
"id": "C0032616",
"name": "polyurethane",
"pos": [
4,
16
]
} | {
"id": "C0013766",
"name": "elastomers",
"pos": [
17,
27
]
} |
the association of thrombin with cef is specific , since the non-mitogenic serine protease chymotrypsin is internalized to a much lesser extent than thrombin . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
75,
90
]
} | {
"id": "C0008742",
"name": "chymotrypsin",
"pos": [
91,
103
]
} |
growth stimulation of either fetal rat liver cells or rat embryo fibroblasts in culture results in considerable increases in intracellular polyamine levels as cells proceed through the cell cycle . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
65,
76
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
159,
164
]
} |
in 3t3 swiss mouse fibroblasts , incorporation of phosphate into cells and phosphorylation of small organic compounds were increased by shaking dense cultures . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
19,
30
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
65,
70
]
} |
determination of trimethoprim and sulfamethoxazole ( co-trimoxazole ) in body fluids of man by means of high-performance liquid chromatography . | NA | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
34,
50
]
} | {
"id": "C0041044",
"name": "co-trimoxazole",
"pos": [
53,
67
]
} |
rapid quantitative method for the simultaneous determination of carbamazepine , carbamazepine-10,11-epoxide , diphenylhydantion , mephenytoin , phenobarbital and primidone in serum by thin-layer chromatography . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
144,
157
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
162,
171
]
} |
the mechanism by which the kidney reabsorbs sodium bicarbonate could be a result of ( a ) h+ secretion , ( b ) direct hco3- reabsorption , or ( c ) a combination of both processes . | NA | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
44,
62
]
} | {
"id": "C0005367",
"name": "hco3",
"pos": [
118,
122
]
} |
clinical isolates of enterococci ( streptococcus faecalis ) with high-level resistance to both streptomycin and kanamycin ( minimal inhibitory concentration > 2,000 mug/ml ) , and resistant to synergism with penicillin and streptomycin or kanamycin were examined for aminoglycoside-inactivating enzymes . | NA | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
95,
107
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
267,
281
]
} |
clinical isolates of enterococci ( streptococcus faecalis ) with high-level resistance to both streptomycin and kanamycin ( minimal inhibitory concentration > 2,000 mug/ml ) , and resistant to synergism with penicillin and streptomycin or kanamycin were examined for aminoglycoside-inactivating enzymes . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
112,
121
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
267,
281
]
} |
quantitative phosphorylation of amikacin in vitro by a sonicate of the transconjugant strain inactivated the antibiotic , as measured by bioassay , and the phosphorylated drug failed to produce synergism when combined with penicillin against a strain sensitive to penicillin-amikacin synergism.no differences were found in the sensitivity of ribosomes from a sensitive and resistant strain when examined in vitro using polyuridylic acid directed [ ( 14 ) c ] -phenylalanine incorporation in the presence of streptomycin , kanamycin , or amikacin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
522,
531
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
537,
545
]
} |
in vitro studies of gallstones indicate that the presence and magnitude of the acoustic shadow depend on a number of factors and suggest that a group of small stones may be demonstrable even though no acoustic shadow can be seen . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
20,
30
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
159,
165
]
} |
a spontaneously occurring antibasement membrane antibody has been further characterised according to antigenic specificity , immunoglobulin class , and tissue localisation using immunofluorescent and immunoelectron microscopic techniques . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
48,
56
]
} | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
125,
145
]
} |
in nine normal leucocyte extracts , binding measured by sephadex g-75 filtration ranged from 1.3 to 18.2 ( mean 8.2 ) pg/mg protein and by albumin-coated charcoal from 1.0 to 14.8 ( mean 6.7 ) pg/mg protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
139,
146
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
199,
206
]
} |
since pge-like substances are synthesized in the brain , these data suggest the possibility that the prostaglandin may be involved in the regulation of water balance as a component of a reciprocal system in which water intake initiated by the activation of the renin-angiotensin system is halted by the synthesis and release of pge . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
101,
114
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
328,
331
]
} |
the effects of pentobarbital on vep amplitude varied as a function of flash intensity , and this barbiturate anesthetic also produced qualitative vep waveform changes . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
15,
28
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
97,
108
]
} |
four patients had active orbital disease and proptosis , and each was found to have orbital masses accompanied by varying degrees of bone and sinus destruction . | NA | {
"id": "C0029182",
"name": "orbital disease",
"pos": [
25,
40
]
} | {
"id": "C0015300",
"name": "proptosis",
"pos": [
45,
54
]
} |
mammary infusion of the plant lectin concanavalin a , a protein which binds to cell surface receptors , produces similar changes in milk flow to those of the microtubule antagonists . | NA | {
"id": "C0304052",
"name": "plant",
"pos": [
24,
29
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
37,
51
]
} |
dominant cystoid macular dystrophy ( d.c.m.d . ) is characterized by a macular dystrophy but at the same time by a pigmentary dystrophy of the retinal periphery . | NA | {
"id": "C0024440",
"name": "dominant cystoid macular dystrophy",
"pos": [
0,
34
]
} | {
"id": "C0242383",
"name": "macular",
"pos": [
71,
78
]
} |
the empirical evidence of psychosexual functioning does not support money 's schema which suggest that sexual variation ( homosexuality ) , transsexualism , and transvestism are incongruities of gender identity . | NA | {
"id": "C0030482",
"name": "sexual variation",
"pos": [
103,
119
]
} | {
"id": "C0040774",
"name": "transvestism",
"pos": [
161,
173
]
} |
among antisera of 12 rabbits examined during their peak antibody production periods , 1 to 20 mg ( mean , 5.4 mg ) of antidigoxin antibody could be recovered from 1 ml of serum . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
6,
14
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
130,
138
]
} |
antisera from five of these 12 rabbits contained antidigoxin antibodies of restricted heterogeneity as demonstrated by urea-polyacrylamide disc gel electrophoresis of fully reduced and alkylated antibodies . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
0,
8
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
195,
205
]
} |
from the antisera of four of these five rabbits , electrophoretically homogeneous antibodies ( 1 to 5 mg/ml antiserum ) could be isolated by affinity chromatography on ouabain-amine-sepharose columns . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
82,
92
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
108,
117
]
} |
several antisera and strain combinations were evaluated in which the antisera could contain antibodies specific for products of genes encoded by the i-j subregion , but the results were inconclusive . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
8,
16
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
92,
102
]
} |
autocytotoxicity was assessed in vitro ( cytotoxicity of c57bl/6 fibroblasts ) and in vivo ( splenomegaly and popliteal node enlargement in c57bl/6 mice ) . | NA | {
"id": "C0038002",
"name": "splenomegaly",
"pos": [
93,
105
]
} | {
"id": "C0020564",
"name": "enlargement",
"pos": [
125,
136
]
} |
concanavalin a , a plant lectin that inhibited igm but not igg hemolytic activity , inhibited the hemolytic activity of igg-protein a complexes that behaved like igm but had no effect on complexes that behaved functionally like igg . | NA | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
0,
14
]
} | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
19,
31
]
} |
following immunological reaction of the antibodies in an antiserum with the antigen adsorbent , the specific immunoglobulin is chemically bound to the antigen by means of the divalent crosslinking agent . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
40,
50
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
57,
66
]
} |
of the four irradiated patients , one had a child with down 's syndrome and another had a child with multiple congenital anomalies who died . | NA | {
"id": "C0013080",
"name": "down 's syndrome",
"pos": [
55,
71
]
} | {
"id": "C0000772",
"name": "multiple congenital anomalies",
"pos": [
101,
130
]
} |
the isadrine effect was blocked by beta -- blocking agent inderal , whereas those of adrenaline and noradrenaline -- by alpha-blocking drug phentolamine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
85,
95
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
100,
113
]
} |
the remaining 3 balsams , however ( colophony , turpentine and wood tars ) , are also screening agents for essential oils . | NA | {
"id": "C0041411",
"name": "turpentine",
"pos": [
48,
58
]
} | {
"id": "C0028910",
"name": "essential oils",
"pos": [
107,
121
]
} |
mechanism of action of somatostatin : growth-hormone release [ 45ca ] calcium ion efflux and cyclic nucleotide metabolism of bovine anterior-pituitary slices in the presence of prostaglandin e2 and 1-methyl-3-isobutylxanthine . | NA | {
"id": "C0037663",
"name": "growth-hormone",
"pos": [
38,
52
]
} | {
"id": "C0032016",
"name": "anterior-pituitary",
"pos": [
132,
150
]
} |
of these 60 children , 52 had a history suggestive of epilepsy or of febrile convulsions . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
54,
62
]
} | {
"id": "C0009952",
"name": "febrile convulsions",
"pos": [
69,
88
]
} |
mouse myeloid leukemia cells were induced by some corticoid hormones to migrate in agar , phagocytize , and change into forms which were morphologically similar to macrophages and granulocytes . | NA | {
"id": "C0001617",
"name": "corticoid",
"pos": [
50,
59
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
60,
68
]
} |
the tendency for higher levels to occur in those patients with greater disturbances of liver function suggests altered metabolism or excretion of cea . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
119,
129
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
133,
142
]
} |
the administration of oral or parenteral vancomycin to recipients of clindamycin or lincomycin was uniformly protective in 49 patients . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
69,
80
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
84,
94
]
} |
comparative effects of epinephrine and norepinephrine on plasma glucose and hematocrit levels in the american bullfrog ( rana catesbeiana ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
23,
34
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
39,
53
]
} |
body weight change over the life span and longevity for c57bl/6j mice and mutations which differ in maximal body weight . | NA | {
"id": "C0005911",
"name": "body weight change",
"pos": [
0,
18
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
108,
119
]
} |
the serum concentrations of cholic acid ( c ) , chenodeoxycholic acid ( cd ) , and deoxycholic acid ( d ) before and after a standardised meal were determined in five healthy female subjects using a highly specific and accurate gas chromatographic-mass spectrometric technique . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
48,
69
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
83,
99
]
} |
metabolism and toxicity of halogenated carbanilides : absorption , distribution and excretion of radioactivity from 3,4,4'-trichloro [ 14c ] carbanilide ( tcc ) and 3-trifluoromethyl-4,4'-dichloro [ 14c ] carbanilide ( tfc ) in rats . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
0,
10
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
84,
93
]
} |
using nmr techniques , delta deltav 1/2/deltac values , chemical shifts and half-line widths of colchicine protons were analyzed as a function of the dna/colchicine ratio , thus proving the interaction between alkaloid and dna . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
96,
106
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
210,
218
]
} |
by transfusion of [ 3h ] uridine labelled red blood cells it could be shown that the brain nuclear rna preparation was contaminated by 0.41 % rna originating from blood cells . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
91,
102
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
142,
145
]
} |
the binding of the alkaloid colchicine and its metabolite colchiceine to different membranes and gangliosides has been investigated . | NA | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
19,
27
]
} | {
"id": "C0009262",
"name": "colchicine",
"pos": [
28,
38
]
} |
cell membranes were more effective than soluble fractions in adsorbing antibody capacity from the immune sera against whole cells . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
71,
79
]
} | {
"id": "C0020960",
"name": "immune sera",
"pos": [
98,
109
]
} |
these results provide direct evidence for acp activation by opportunist gram-negative bacilli and refute the hypothesis that the lipid a moiety of the lipopolysaccharide cell wall is responsible for acp activation . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
129,
136
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
151,
169
]
} |
although definitive evidence is lacking , there are data suggesting that this peptide is a proteolytic fragment from the adp-ribosylating toxin ( exotoxin a ; molecular weight , 66,000 ) produced by the same strain of p. aeruginosa . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
138,
143
]
} | {
"id": "C0015309",
"name": "exotoxin",
"pos": [
146,
154
]
} |
the purified t-antigen was resistant to enzymatic degradation with trypsin and pepsin , formed a single precipitin line with standard t-1 antiserum , failed to react with antisera for teichoic acid , group a carbohydrate , and cross-reactive protein antigens , stimulated only a single precipitin system when rabbits were immunized , contained glycine , aspartic acid , glutamic acid , lysine , and serine as the five most predominant amino acids , and consisted of subunit size isomers . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
344,
351
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
435,
446
]
} |
syrian hamsters were injected with inactivated , attenuated , and virulent rabies virus ( rv ) , and the antibody response was quantified by a neutralization test and the immunoglobulin class of the virus antibody was characterized by indirect fluorescent microscopy . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
171,
191
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
205,
213
]
} |
immunoglobulin classes of antibodies in milk of swine after intranasal exposure to pseudorabies virus or transmissible gastroenteritis virus . | NA | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
0,
22
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
26,
36
]
} |
experiments were conducted to evaluate whether infection of the respiratory tract of pregnant swine with pseudorabies ( pr ) virus would induce the secretion of immunoglobulin a ( iga ) antibodies in their milk as was observed after enteric infection with transmissible gastroenteritis ( tge ) virus . | NA | {
"id": "C0035243",
"name": "infection",
"pos": [
47,
56
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
241,
250
]
} |
by comparison , tge antibodies were primarily of the iga class , with varying but lesser amounts of antibody associated with the igg class . | NA | {
"id": "C0021017",
"name": "iga class",
"pos": [
53,
62
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
100,
108
]
} |
since the abscess form of the disease was not prevented by immunization with either alpha- or beta-toxin , other virulence factors must be acting to produce this more localized disease . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
99,
104
]
} | {
"id": "C1136170",
"name": "virulence factors",
"pos": [
113,
130
]
} |
moreover , a variety of heat-killed intestinal and gram-negative bacteria , live e. coli , and complexes of lipid a with a variety of proteins substituted for lps in the synergistic toxicity of lps and delta 9-thc . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
108,
115
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
194,
197
]
} |
purified endotoxin ( lps ) caused macrophage migration inhibition ( mmi ) in capillary tube cultures of guinea pig peritoneal macrophages in medium prepared with 15 % fresh-frozen guinea pig serum . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
9,
18
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
21,
24
]
} |
it is suggested that the h-lps-induced alteration of erythrocyte cation content was secondary to an increase in ion permeability localized to the concanavalin a receptor regions of the erythrocyte membrane , possibly combined with indirect effects of membrane-bound h-lps on ethacrynic acid-sensitive adenosine triphosphatase . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
65,
71
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
173,
176
]
} |
this may be a general property of antidepressants , since it has been previously described with other groups of antidepressants . | NA | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
34,
49
]
} | {
"id": "C1579362",
"name": "other",
"pos": [
96,
101
]
} |
enzymes and isoenzymes in different body tissue and fluids in benign and malignant gynecological tumors . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
0,
7
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
12,
22
]
} |
ascites , hepatic encephalopathy , and bleeding esophageal and gastric varices are frequent consequences of hepatic disease and portal hypertension . | NA | {
"id": "C0023895",
"name": "hepatic disease",
"pos": [
108,
123
]
} | {
"id": "C0020541",
"name": "portal hypertension",
"pos": [
128,
147
]
} |
an electrophoretically hba-like hemoglobin component is produced in increasing amounts during storage in hemolysate preparations from macerated tissue ( liver , kidney , spleen ) of fetuses . | NA | {
"id": "C0019016",
"name": "hba",
"pos": [
23,
26
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
32,
42
]
} |
hb vaasa or alpha2beta2 ( 39 ( c5 ) gln replaced by glu ) , a mildly unstable variant found in a finnish family . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
36,
39
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
52,
55
]
} |
the daily dosage of penicillin g ranged from 110,000 to 165,000 u/kg ( 50,000-75,000 u/lb ) , and the dosage of ampicillin varied from 77 to 110 mg/kg ( 35-50 mg/lb ) . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
20,
32
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
112,
122
]
} |
mean concentrations of penicillin g and ampicillin in urines collected at 6-hour intervals after oral administration to clinically normal adult dogs were approximately 350 microgram/ml for both drugs when each was given individually in daily dosages ( divided qid ) of 55 mg/kg ( 25 mg/lb ) . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
23,
35
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
40,
50
]
} |
bl-s786 was compared by in vitro studies with 6 other parenteral cephalosporins ( cefamandole , cefazolin , cefoxitin , cephaloridine , cephalothin and cephradine ) . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
65,
79
]
} | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
120,
133
]
} |
a laboratory and clinical investigation of mecillinam and its ester pivmecillinam in the treatment of urinary tract infections . | NA | {
"id": "C0002435",
"name": "mecillinam",
"pos": [
43,
53
]
} | {
"id": "C0002436",
"name": "pivmecillinam",
"pos": [
68,
81
]
} |
to test this latter concept , we compared three different isomers of dinitrophenol ( i.e. , 2,4-dinitrophenol ( 2,4-dnp ) , 2,5-dinitrophenol ( 2,5 , -dnp ) , 2,6-dinitrophenol ( 2,6-dnp ) with respect to stimulation of ve and with respect to stimulation of oxygen consumption ( vo2 ) . | NA | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
69,
82
]
} | {
"id": "C0045511",
"name": "dnp",
"pos": [
183,
186
]
} |
the process leading to increase in hpns convulsion pressure is initiated at the very beginning of compression , proceeds at increasingly rapid rates as higher pressures are attained , and approaches a limiting upper convulsion pressure . | NA | {
"id": "C0014544",
"name": "hpns convulsion",
"pos": [
35,
50
]
} | {
"id": "C0036572",
"name": "convulsion",
"pos": [
216,
226
]
} |
recovery of cyanide from potassium cyanide at a level equivalent to 243 microgram cn-/g was 101.0 % . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
12,
19
]
} | {
"id": "C0032826",
"name": "potassium cyanide",
"pos": [
25,
42
]
} |
reserpine-rescinnamine group alkaloids are extracted from rauwolfia serpentina preparations into dimethylsulfoxide ( dmso ) -methanol and diluted with 0.5n h2so4 . | NA | {
"id": "C0035179",
"name": "reserpine",
"pos": [
0,
9
]
} | {
"id": "C0035167",
"name": "group",
"pos": [
23,
28
]
} |
a portion of the eluate is treated with a vanadium pentoxide-phosphoric acid solution , and the reserpine-rescinnamine content is determined by measuring the intensity of the resulting fluorescence . | NA | {
"id": "C0035179",
"name": "reserpine",
"pos": [
96,
105
]
} | {
"id": "C0035167",
"name": "content",
"pos": [
119,
126
]
} |
the following means and standard deviations ( 11 collaborators ) were obtained for the determination of reserpine-rescinnamine group alkaloids in 4 samples of rauwolfia serpentina ( nf reference powder , 100 and 50 mg commercial tablets , and 45 mg synthetic tablet formation ) : 0.173 % , 0.0050 ; | NA | {
"id": "C0035179",
"name": "reserpine",
"pos": [
104,
113
]
} | {
"id": "C0035167",
"name": "group",
"pos": [
127,
132
]
} |
a 20 g crop-methanol extract is cleaned up by adsorbing the sample onto gas-chrom s. desorbing etu , and eluting etu from aluminum oxide with chloroform containing ethanol . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
12,
20
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
164,
171
]
} |
a paper disk method based on a procedure described by the international dairy federation is presented for the detection of 4 beta-lactam antibiotics ( penicillin g , ampicillin , cephapirin , and cloxacillin ) in whole milk . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
151,
163
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
166,
176
]
} |
the final products of the arginine catabolism that can be utilized as a nitrogen source in neurospora crassa are ammonium , glutamic acid , and glutamine . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
124,
137
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
144,
153
]
} |
the addition of glutamine or glutamic acid plus ammonium to this strain decreased by threefold the induction of arginase by arginine . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
16,
25
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
29,
42
]
} |
none of the beta-lactamases produced by beta-lactam antibiotic-resistant strains of other species of proteus was affected at all by the antibodies , thus showing that the purified cephalosporin beta-lactamase was of the species-specific type . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
12,
27
]
} | {
"id": "C0728805",
"name": "cephalosporin beta-lactamase",
"pos": [
180,
208
]
} |
neither spontaneous decomposition of noniron metalloporphyrin chelates nor spontaneous formation of hemes from fe2+ and metal-free porphyrins was detected . | NA | {
"id": "C0025541",
"name": "metalloporphyrin",
"pos": [
45,
61
]
} | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
131,
141
]
} |
competition studies employing phenylalanine or non-leucine-containing peptides showed that the uptake of peptides into s. cerevisiae z1-2d is distinct from that of amino acids and that di- and oligopeptides may share a common transport system . | NA | {
"id": "C0030956",
"name": "peptides",
"pos": [
70,
78
]
} | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
193,
206
]
} |
two species of the enzyme ( isozymes i and ii ) were separated by de-52 cellulose column chromatography from healthy , cut , and black-rot diseased tissues . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
19,
25
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
28,
36
]
} |
there was one major glycoprotein , possibly alpha 1-antitrypsin , and two minor proteins one of which was albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
80,
88
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
106,
113
]
} |
further studies on the properties of the polypeptide chain elongation factors tu and ts : hydrogen-tritium exchange , optical rotatory dispersion , and intrinsic fluorescence . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
90,
98
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
99,
106
]
} |
by measuring the fluorescence intensities of the tryptophanyl residues and fad of the holoenzyme solution , and the fluorescence polarization of the holoenzyme solution containing halide anions such as iodide , bromide , chloride , or fluoride , we found that fad dissociates from the holoenzyme in the presence of iodide , bromide , or chloride , and the ability to dissociate fad from the holoenzyme decreases in order iodide , bromide , and chloride . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
187,
193
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
235,
243
]
} |
by measuring the fluorescence intensities of the tryptophanyl residues and fad of the holoenzyme solution , and the fluorescence polarization of the holoenzyme solution containing halide anions such as iodide , bromide , chloride , or fluoride , we found that fad dissociates from the holoenzyme in the presence of iodide , bromide , or chloride , and the ability to dissociate fad from the holoenzyme decreases in order iodide , bromide , and chloride . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
187,
193
]
} | {
"id": "C0021966",
"name": "iodide",
"pos": [
421,
427
]
} |
by measuring the fluorescence intensities of the tryptophanyl residues and fad of the holoenzyme solution , and the fluorescence polarization of the holoenzyme solution containing halide anions such as iodide , bromide , chloride , or fluoride , we found that fad dissociates from the holoenzyme in the presence of iodide , bromide , or chloride , and the ability to dissociate fad from the holoenzyme decreases in order iodide , bromide , and chloride . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
187,
193
]
} | {
"id": "C0006222",
"name": "bromide",
"pos": [
430,
437
]
} |
by measuring the fluorescence intensities of the tryptophanyl residues and fad of the holoenzyme solution , and the fluorescence polarization of the holoenzyme solution containing halide anions such as iodide , bromide , chloride , or fluoride , we found that fad dissociates from the holoenzyme in the presence of iodide , bromide , or chloride , and the ability to dissociate fad from the holoenzyme decreases in order iodide , bromide , and chloride . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
187,
193
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
444,
452
]
} |
this residue was protected by ethylene glycol chitin , n-acetyl glucosamine ( nag ) , and tri-nag , but not by gluconolactone . | NA | {
"id": "C0001056",
"name": "n-acetyl glucosamine",
"pos": [
55,
75
]
} | {
"id": "C0017718",
"name": "nag",
"pos": [
94,
97
]
} |
lipid micelles were prepared by incubating a mixture of glycerides ( triolein , diolein , and monoolein ) , and lecithin in krebs-ringer phosphate buffer at 37 degrees c for 30 min . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
0,
5
]
} | {
"id": "C0017860",
"name": "glycerides",
"pos": [
56,
66
]
} |
dibutyryl cyclic amp , theophylline , and phospholipase c increased the rate of lipolysis in the system but cyclic amp and phospholipase d did not . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
0,
20
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
108,
118
]
} |
relation between the kcl-soluble protein stimulating amino acid incorporation and proteins from the ribosomal wash fraction in sea urchin systems . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
33,
40
]
} | {
"id": "C0035552",
"name": "proteins",
"pos": [
82,
90
]
} |
the exchange reaction of peptide hydrogens with deuterium has been followed by measuring the decrease of the amide ii band for heavy meromyosin ( hmm ) . | NA | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
33,
42
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
48,
57
]
} |
since the gtp-sensitive form of the glucagon receptor complex separates from the gpp ( nh ) p-sensitive form of adenylate cyclase , it is concluded that the receptor and the enzyme are separate molecules , each associated with a distinct nucleotide regulatory site or component . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
10,
13
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
81,
93
]
} |
after affinity chromatography the lectin is pure except for minor contamination with another protein possibly representing a second muscle lectin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
93,
100
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
139,
145
]
} |
for all equilibrium exchanges studied ( atp in equilibrium adp , atp in equilibrium pi , and glu in equilibrium gln ) , the rate of exchange rose smoothly to a maximum as all substrates and products were simultaneously raised in a constant ratio . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
93,
96
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
112,
115
]
} |
activated factor xii converts prekallikrein to kallikrein by limited proteolysis and two disulfide-linked chains designated kallikrein heavy chain ( mr = 52,000 ) and kallikrein light chains ( mr = 36,000 or 33,000 ) are formed . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
30,
43
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
167,
177
]
} |
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