text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
based on the immunoprecipitin turbidimetric reaction enhanced by polyethylene-glycol , the technique , simple and fast , gives precise and accurate results with following cautions : the antigen and antibody concentrations must be carefully chosen according to defined specific antiserum , and two dilutions of each serum sample must be assayed to control quite satisfactory determination and exhibit any antigen excess error . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
198,
206
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
277,
286
]
} |
but unlike pancreatic elastase , leukocyte elastase produces emphysema that is mild , even at a dose sufficient to produce intense lung hemorrhage and a high mortality . | NA | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
11,
30
]
} | {
"id": "C0064833",
"name": "leukocyte elastase",
"pos": [
33,
51
]
} |
out of the discovery of concurrent multiple endocrine neoplasms has evolved the concept of multiple endocrine adenomatosis ( mea1 and mea2 ) . | NA | {
"id": "C0027662",
"name": "multiple endocrine neoplasms",
"pos": [
35,
63
]
} | {
"id": "C0025267",
"name": "multiple endocrine adenomatosis",
"pos": [
91,
122
]
} |
diagnoses were , in descending order of frequency , cardiorespiratory diseases , malignancy , fracture , diseases of the central nervous system , infection/inflammation , hepatic cirrhosis and/or alcoholism , trauma without fracture , infectious mononucleosis , hypothyroidism , uremia , necrosis , pseudomononucleosis , viremia and intestinal obstruction . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
209,
215
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
224,
232
]
} |
partial monosomy 11q due to a de novo 11q231 leads to 11qter deletion was detected in a patient who died at seven days of age with most malformations characteristic of monosomy 11q , including trigonocephaly , facial dysmorphia , and congenital heart disease . | NA | {
"id": "C0008628",
"name": "partial monosomy",
"pos": [
0,
16
]
} | {
"id": "C0026499",
"name": "monosomy",
"pos": [
168,
176
]
} |
[ enzyme-immunoassay of grass-pollen and mites antibodies in rabbit antisera on magnetic polyacrylamide agarose beads ( author 's transl ) ] . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
47,
57
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
68,
76
]
} |
to investigate the role of growth regulatory protein in this process we have determined the patterns of synthesis of acidic ( non-histone , nhcp ) and basic ( histone ) nuclear chromatin proteins , and of cytoplasmic proteins during pha activation of human lymphocytes , protein fractions isolated from a mixture of stimulated ( pulse-labelled with 14c leucine ) and unstimulated ( labelled with 3h-leucine ) lymphocytes were separated on sds-polyacrylamide gel electrophoresis and the ratio of 14c/3h determined on 1 mm gel slices . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
130,
137
]
} | {
"id": "C0028589",
"name": "nuclear",
"pos": [
169,
176
]
} |
to investigate the role of growth regulatory protein in this process we have determined the patterns of synthesis of acidic ( non-histone , nhcp ) and basic ( histone ) nuclear chromatin proteins , and of cytoplasmic proteins during pha activation of human lymphocytes , protein fractions isolated from a mixture of stimulated ( pulse-labelled with 14c leucine ) and unstimulated ( labelled with 3h-leucine ) lymphocytes were separated on sds-polyacrylamide gel electrophoresis and the ratio of 14c/3h determined on 1 mm gel slices . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
169,
176
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
271,
278
]
} |
two cephalosporin antibiotics , cefaclor and cephalexin , were administered orally to healthy , adult male volunteers for comparison of their pharmacological properties . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
32,
40
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
45,
55
]
} |
in doses of 250 mg orally , cefaclor produced a peak serum concentration of 6.01 +/- 0.55 ( standard deviation [ sd ] ) mug/ml compared with 9.43 +/- 2.36 mug/ml for cephalexin ( p < 0.01 ) . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
28,
36
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
166,
176
]
} |
the half-lives were 0.58 +/- 0.07 ( sd ) h and 0.80 +/- 0.12 ( sd ) h , and elimination constants were 1.22 +/- 0.15 and 0.88 +/- 0.13 h ( -1 ) for cefaclor and cephalexin , respectively ( p < 0.001 ) . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
148,
156
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
161,
171
]
} |
a mutant uncoupled for adenosine 5'-triphosphate synthesis from electron transport and membrane mg-adenosine 5'-triphosphatase deficient was hypersensitive to those aminoglycosides tested and spectinomycin , and showed enhanced transport of streptomycin and gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
165,
180
]
} | {
"id": "C0001268",
"name": "spectinomycin",
"pos": [
192,
205
]
} |
a mutant uncoupled for adenosine 5'-triphosphate synthesis from electron transport and membrane mg-adenosine 5'-triphosphatase deficient was hypersensitive to those aminoglycosides tested and spectinomycin , and showed enhanced transport of streptomycin and gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
165,
180
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
241,
253
]
} |
a mutant uncoupled for adenosine 5'-triphosphate synthesis from electron transport and membrane mg-adenosine 5'-triphosphatase deficient was hypersensitive to those aminoglycosides tested and spectinomycin , and showed enhanced transport of streptomycin and gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
165,
180
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
258,
268
]
} |
penicillin/netilmicin and penicillin/sisomicin combinations were found to be synergistic against the majority of isolates tested , including strains resistant to penicillin/streptomycin or penicillin/kanamycin combinations . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
11,
21
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
37,
46
]
} |
this synergy with penicillin could be demonstrated at a concentration of < /=7 mug/ml for either netilmicin or sisomicin . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
97,
107
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
111,
120
]
} |
rabbit antiserum obtained against this mulb 250 beta-lactamase showed no cross-reaction with other penicillinases or cephalosporinases in neutralization tests . | NA | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
48,
62
]
} | {
"id": "C0030841",
"name": "penicillinases",
"pos": [
99,
113
]
} |
rabbit antiserum obtained against this mulb 250 beta-lactamase showed no cross-reaction with other penicillinases or cephalosporinases in neutralization tests . | NA | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
48,
62
]
} | {
"id": "C0728805",
"name": "cephalosporinases",
"pos": [
117,
134
]
} |
comparisons of results obtained with other beta-lactamases , particularly from enterobacter cloacae p99 , indicate that the enterobacter mulb 250 enzyme presents a typical cephalosporinase profile . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
43,
58
]
} | {
"id": "C0728805",
"name": "cephalosporinase",
"pos": [
172,
188
]
} |
inh also inhibited both the oxidized nicotinamide adenine dinucleotide ( nad ( + ) ) and adenosine 5'-monophosphate stimulation of reduced nad ( nadh ) oxidase activity associated with the m. phlei and m. tuberculosis h ( 37 ) r ( a ) electron transport particles . | NA | {
"id": "C0001413",
"name": "adenosine",
"pos": [
89,
98
]
} | {
"id": "C0027270",
"name": "nad",
"pos": [
145,
148
]
} |
therefore , inh inhibition of regulation and/or stabilization of the electron transport pathway by nad ( + ) or adenosine 5'-monophosphate may account , in part , for the lethal action of the drug on mycobacteria . | NA | {
"id": "C0027270",
"name": "nad",
"pos": [
99,
102
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
112,
123
]
} |
penicillin , methicillin , and , possibly , bacitracin appeared more effective at 37 than at 30 degrees c . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
0,
10
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
13,
24
]
} |
simple method for elimination of aminoglycosides from serum to permit bioassay of other antimicrobial agents . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
33,
48
]
} | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
88,
108
]
} |
the in vitro activity of cefaclor and cephalexin against clinical isolates of four bacterial genera was compared . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
25,
33
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
38,
48
]
} |
both agents had a similar range of activity , but cefaclor was significantly more active by weight than cephalexin for most isolates tested . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
50,
58
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
104,
114
]
} |
the cases are described of three patients with a carcinoid syndrome resulting from hepatic metastases of a carcinoid in the distal ileal tract . | NA | {
"id": "C0024586",
"name": "carcinoid syndrome",
"pos": [
49,
67
]
} | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
107,
116
]
} |
the presence of dermatitis may play an important role in the diminished cell-mediated immunity in atopic dermatitis . | NA | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
16,
26
]
} | {
"id": "C0011615",
"name": "atopic dermatitis",
"pos": [
98,
115
]
} |
[ vaginal cytology after intra-amniotic injection of hypertonic urea for interruption of pregnancy during the second trimester ( author 's transl ) ] . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
89,
98
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
110,
126
]
} |
cell populations from all sources included varying proportions of macrophage-like and fibroblast-like cells , with only 1-3 % multinucleated cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
0,
4
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
86,
96
]
} |
spondylolysis was found in 2 subjects ( 4.3 % ) and spondylolisthesis unassociated with spondylolysis in 4 ( 8.7 % ) . | NA | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
52,
69
]
} | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
88,
101
]
} |
this study does not implicate parachuting as a cause of intervertebral disc degeneration , either cervical or lumbar , nor as a cause of spondylolysis or spondylolisthesis . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
137,
150
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
154,
171
]
} |
normal blood pressure , hypokalemic alkalosis , and hyperaldosteronism , with insensitivity to the pressor effect of angiotensin infusion , were present . | NA | {
"id": "C0004775",
"name": "hypokalemic alkalosis",
"pos": [
24,
45
]
} | {
"id": "C0020428",
"name": "hyperaldosteronism",
"pos": [
52,
70
]
} |
ten clinically intact weaned piglets were experimentally intoxicated by intravenous injection of lipoproteide-free lipopolysaccharide endotoxin according to westphal of e. coli o 127 : b8 . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
115,
133
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
134,
143
]
} |
lipopolysaccharide endotoxin alone may be responsible for the development of both edemas and neurotoxic symptoms ( edema disease ) and diarrhoea ( gastro-intestinal form of coli-enterotoxaemia ) . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
0,
18
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
19,
28
]
} |
the amount of catecholamines ( adrenaline and noradrenaline ) in the venous blood plasma and in the adrenal tissue was the index of the sympathoadrenal system condition . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
31,
41
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
46,
59
]
} |
at the ultrastructural level such homeostatic mechanism is realized in two stages : ( 1 ) resorption by macrophages of collagenic fibrillae of the tissue necrotized as a result of trauma and inflammation , induction of collagen genesis by cell contacts between macrophages and fibroblasts , enhanced fibrillogenesis ; | NA | {
"id": "C0969669",
"name": "collagenic fibrillae",
"pos": [
119,
139
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
219,
227
]
} |
at the ultrastructural level such homeostatic mechanism is realized in two stages : ( 1 ) resorption by macrophages of collagenic fibrillae of the tissue necrotized as a result of trauma and inflammation , induction of collagen genesis by cell contacts between macrophages and fibroblasts , enhanced fibrillogenesis ; | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
239,
243
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
277,
288
]
} |
areas of the necrotized muscle obtained at autopsy of 11 individuals who had died of myocardial infarction of various periods of duration , 12 biopsy specimens of the myocardium obtained during the operation for correction of congenital heart defects of the type of fallot 's tetrad and isolated defects of the septum with various periods of extracorporeal circulation and hearts of 35 male wistar rats with a damaged myocardium ( lesions being induced by intro-abdominal injection of noradrenalin in a dose of 2.5 mg/kg ) , which were sacrified 6 hours following the exposure to noradrenalin , were studied . | NA | {
"id": "C0018798",
"name": "of congenital heart defects",
"pos": [
223,
250
]
} | {
"id": "C0018816",
"name": "defects",
"pos": [
296,
303
]
} |
the therapeutics results with the use of different drugs ( diazepam , nitrazepam , clonazepam , diphenylhydantoin , barbiturates -- phenobarbital and primidone -- , sodium dipropylacetate and acth ) in twenty-nine patients with lennox -- gastaut syndrome are carefully analysed . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
132,
145
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
150,
159
]
} |
the uptake was not affected by amodiaquin , a histamine n-methyl-transferase inhibitor , by the metabolites 1,4-methylhistamine or imidazole acetic acid , by compound 48/80 or by the basic amino acid arginine . | NA | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
183,
199
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
200,
208
]
} |
our observations support the concept that these cells are not directly homologous to immunologically competent vertebrate lymphocytes , but may serve as haemopoietic stem cells as proposed by other ( endean , 1954 ; freeman , 1970 ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
48,
53
]
} | {
"id": "C0018956",
"name": "haemopoietic stem cells",
"pos": [
153,
176
]
} |
[ enterotoxin-producing e.-coli bacteria in enteritis and edema disease of swine . quick diagnosis of heat-labile and heat resistant toxin ] . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
2,
13
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
133,
138
]
} |
cathepsin b , a tissue ( lysosomal ) proteinase , and two humoral proteinases , plasmin and kallikrein , activate the latent collagenase ( 'procollagenase ' ) which is released by mouse bone explants in culture . | NA | {
"id": "C0030946",
"name": "proteinase",
"pos": [
37,
47
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
66,
77
]
} |
alanine , glutamine+glutamate and other 'gluconeogenic ' amino acids decrease dramatically by mid-term , but regain their original concentrations at the end of the pregnancy . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
57,
68
]
} |
the enzyme system catalysing the norethindrone-mediated loss of cytochrome p-450 had many characteristics of the microsomal mixed-function oxidases . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
64,
80
]
} | {
"id": "C0003927",
"name": "microsomal mixed-function oxidases",
"pos": [
113,
147
]
} |
cadaverine appeared to be an especially suitable compound for use as an inhibitor of the synthesis of higher polyamines , at least in ehrlich ascites cells , since this diamine also acted as a competitive inhibitor for putrescine in the spermidine synthase reaction without being incorporated into the higher polyamines . | NA | {
"id": "C0011957",
"name": "diamine",
"pos": [
169,
176
]
} | {
"id": "C0032433",
"name": "polyamines",
"pos": [
309,
319
]
} |
the combination of trimethoprim + sulfametrole ( 1 + 20 ) had the same antibacterial activity as the combination co-trimoxazole = trimethoprim + nd- ( 5-methyl-3-isoxazolyl ) -sulfanilamide ( sulfamethoxazole ; smz ) . | NA | {
"id": "C0041044",
"name": "co-trimoxazole",
"pos": [
113,
127
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
192,
208
]
} |
norepinephrine ( 5 x 10 ( -6 ) m ) and epinephrine ( 4.5 x 10 ( -6 ) m ) did not affect acetylcholine-induced contraction , but reduced the contractile response to tm by about 40 % and 60 % , respectively . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
39,
50
]
} |
phentolamine , but not propranolol , abolished the inhibitory effects of norepinephrine and epinephrine on the contraction induced by tm . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
73,
87
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
92,
103
]
} |
the possibility that norepinephrine and epinephrine act on the inhibitory alpha-adrenoreceptors in the ending of cholinergic neuron is discussed . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
21,
35
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
40,
51
]
} |
among oestrogens mestranol ( infecundin ) gives a higher glycogen production in the liver than ethinyloestradiol ( bisecurin ) ; | NA | {
"id": "C0025506",
"name": "mestranol",
"pos": [
17,
26
]
} | {
"id": "C0015011",
"name": "ethinyloestradiol",
"pos": [
95,
112
]
} |
absorption , metabolism and excretion of 14c-gfa following i.v. , i.p . and oral application are investigated in rats . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
13,
23
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
28,
37
]
} |
the 10 mm muscle-strips from the guinea pig terminal ileum digitalis glycosides ( 0.4 microgram/ml beta-acetyl-digoxin or 0.5 microgram/ml k-strophanthin ) induce contractions which are dose-dependently and reversibly prevented by the calcium antagonist n- ( 2-benzyl-ethyl ) -n- ( 1-phenyl-ethyl ) -amine hydrochloride ( fendiline , sensit ) ( 0.01 -- 1 microgram/ml ) . | NA | {
"id": "C0012253",
"name": "digitalis glycosides",
"pos": [
59,
79
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
111,
118
]
} |
in the present investigation a method of induction of experimental arthritis in animals was modified to provide a better model replica of human arthritis . | NA | {
"id": "C0993582",
"name": "experimental arthritis",
"pos": [
54,
76
]
} | {
"id": "C0003864",
"name": "arthritis",
"pos": [
144,
153
]
} |
bm 15.075 decreased very low density lipoproteins ( vldl ) , triglycerides ( tg ) and cholesterol concentration in all types of hyperlipoproteinaemia the effect being dependent on initial lipoprotein concentrations . | NA | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
20,
49
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
188,
199
]
} |
the chemical shifts of the well-resolved ring nitrogen protons of uracil and a series of substituted uracils , including pseudouridine ( 5-ribosyl-uracil ) and uridine ( 1-ribosyl-uracil ) were determined using nuclear magnetic resonance ( nmr ) . | NA | {
"id": "C0033846",
"name": "pseudouridine",
"pos": [
121,
134
]
} | {
"id": "C0041984",
"name": "uridine",
"pos": [
160,
167
]
} |
[ blood sugar and insulin levels during intravenous administration of glucose and the rastinon test in patients with hemicrania ] . | NA | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
2,
13
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
70,
77
]
} |
the diagnostic value of technetium-99m-pyrophosphate ( tc-pyrophosphate ) myocardial scintigraphy was determined in 80 consecutive patients who had been admitted to the coronary care unit in order to rule out an acute myocardial infarction . | NA | {
"id": "C0085250",
"name": "technetium-99m-pyrophosphate",
"pos": [
24,
52
]
} | {
"id": "C0034320",
"name": "pyrophosphate",
"pos": [
58,
71
]
} |
1 the plasma concentration/time curves of ampicillin and mecillinam in normal subjects were measured after oral administration of ampicillin ( 500 mg ) and pivmecillinam ( 400 and 600 mg ) . | NA | {
"id": "C0002435",
"name": "mecillinam",
"pos": [
57,
67
]
} | {
"id": "C0002436",
"name": "pivmecillinam",
"pos": [
156,
169
]
} |
2 similar plasma concentration/time curves of ampicillin and mecillinam in the starved normal subjects followed oral administration of ampicillin ( 500 mg ) and pivmecillinam ( 600 mg ) . | NA | {
"id": "C0002435",
"name": "mecillinam",
"pos": [
61,
71
]
} | {
"id": "C0002436",
"name": "pivmecillinam",
"pos": [
161,
174
]
} |
3 the plasma concentration/time curve of mecillinam was measured in the same normal subjects after oral administration of pivmecillinam ( 400 mg ) with a reproducible standardized lundh test meal . | NA | {
"id": "C0002435",
"name": "mecillinam",
"pos": [
41,
51
]
} | {
"id": "C0002436",
"name": "pivmecillinam",
"pos": [
122,
135
]
} |
4 there was no statistically significant difference in the plasma concentration/time curve of mecillinam after pivmecillinam/400 mg ) and the meal compared with the plasma concentration/time curve after oral pivmecillinam ( 400 mg ) was given to the same subjects when starved . | NA | {
"id": "C0002435",
"name": "mecillinam",
"pos": [
94,
104
]
} | {
"id": "C0002436",
"name": "pivmecillinam",
"pos": [
208,
221
]
} |
the effects of a lundh meal on the plasma concentration/time curve of ampicillin , amoxycillin , pivampicillin and cephalexin in normal subjects [ proceedings ] . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
70,
80
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
83,
94
]
} |
the effects of a lundh meal on the plasma concentration/time curve of ampicillin , amoxycillin , pivampicillin and cephalexin in normal subjects [ proceedings ] . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
70,
80
]
} | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
97,
110
]
} |
1 a simple , rapid and reproducible fluorimetric assay for cephradine , cephalexin and cephaloglycin is described . | NA | {
"id": "C0007738",
"name": "cephradine",
"pos": [
59,
69
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
72,
82
]
} |
1 a simple , rapid and reproducible fluorimetric assay for cephradine , cephalexin and cephaloglycin is described . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
72,
82
]
} | {
"id": "C0007721",
"name": "cephaloglycin",
"pos": [
87,
100
]
} |
when both quinidine bisulphate ( kinidin durules ) and quinidine arabogalactansulphate ( longacor ) were administered plasma levels peaked significantly later than after quinidine sulphate . | NA | {
"id": "C0034414",
"name": "quinidine",
"pos": [
10,
19
]
} | {
"id": "C0034415",
"name": "quinidine sulphate",
"pos": [
170,
188
]
} |
serum concentrations of lithium after three proprietary preparations of lithium carbonate ( priadel , phasal and camcolit ) . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
24,
31
]
} | {
"id": "C0085217",
"name": "preparations",
"pos": [
56,
68
]
} |
1 the serum lithium concentration was measured before dosing , and at 2 , 4 , 6 , 8 , 10 , 20 , 22 , and 24 h after three proprietary preparations of lithium carbonate ( camcolit , phasal or priadel ) . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
12,
19
]
} | {
"id": "C0085217",
"name": "preparations",
"pos": [
134,
146
]
} |
our data demonstrate the suitability of this reagent for mapping available lysyl residues in this and other nucleoproteins and suggest that the related bisimido esters may be reagents of choice for cross-linking of chromatin histones . | NA | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
108,
122
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
215,
224
]
} |
mechanism of lipid-protein interaction in the plasma lipoproteins : lipid-binding properties of synthetic fragments of apolipoprotein a-ii . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
13,
18
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
53,
65
]
} |
these data suggest that factor xii is converted to factor xiia by the cleavage of a specific internal arginyl-valine peptide bond . | NA | {
"id": "C0015525",
"name": "factor xii",
"pos": [
24,
34
]
} | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
51,
62
]
} |
factor xiia , in contrast to factor xii , has hydrolase activity toward arginine-containing substrates and is readily inhibited by antithrombiniii and diisopropyl phosphorofluoridate . | NA | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
0,
11
]
} | {
"id": "C0015525",
"name": "factor xii",
"pos": [
29,
39
]
} |
factor vii is readily converted to factor viia by factor xiia ( activated hageman factor ) employing an enzyme to substrate weight ratio of 1:50 . | NA | {
"id": "C0015502",
"name": "factor vii",
"pos": [
0,
10
]
} | {
"id": "C0015505",
"name": "factor viia",
"pos": [
35,
46
]
} |
endoperoxide trapping experiments employing reduced glutathione show that the conversion of prostaglandin h to prostaglandin f is slow in lipoate containing incubation mixtures . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
92,
105
]
} | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
111,
126
]
} |
further experiments reveal that the reduction of prostaglandin h to prostaglandin f by lipoate is nonenzymatic and occurs after the termination of biosynthesis in the work-up mixture . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
49,
62
]
} | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
68,
83
]
} |
the experiments with isolated and separated lipid classes indicated that the observed increase in fluidity of lipids in choline-starved mycelium is partly due to the difference in physical properties between bulk lipids and membrane lipids . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
110,
116
]
} | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
224,
239
]
} |
surface potential effects on metal ion binding to phosphatidylcholine membranes 31p nmr study of lanthanide and calcium ion binding to egg-yolk lecithin vesicles . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
50,
69
]
} | {
"id": "C0031617",
"name": "lecithin",
"pos": [
144,
152
]
} |
31p nmr of phosphatidylcholine ( lecithin ) from egg-yolk in sonicated vesicles has been measured in the presence of various ions . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
11,
30
]
} | {
"id": "C0031617",
"name": "lecithin",
"pos": [
33,
41
]
} |
the inhibition of rb+ uptake shows saturation kinetics and the phosphate concentration at which half-maximal inhibition is observed is equal to the km of phosphate for the sodium-independent phosphate uptake mechanism . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
63,
72
]
} | {
"id": "C0074757",
"name": "sodium",
"pos": [
172,
178
]
} |
in the case of na+ uptake , the inhibition by phosphate may be partly or completely compensated by stimulation of na+ uptake via a sodium-phosphate cotransport mechanism . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
46,
55
]
} | {
"id": "C0074757",
"name": "sodium-phosphate",
"pos": [
131,
147
]
} |
among a variety of synthetic polynucleotides tested , only poly ( g ) and oligo ( dg ) were effective inhibitors , suggesting a role for guanines or guanine-rich sequences of rna in the inhibition reaction . | NA | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
29,
44
]
} | {
"id": "C0028953",
"name": "oligo",
"pos": [
74,
79
]
} |
nicotine and 2- ( 4-chlorophenylthio ) triethylammonium chloride ( cpta ) each inhibit production of the normal carotenoids of rhodomicrobium vannielii ( rhodospirillaceae ) , especially rhodopin , beta-carotene and spirillixanthin , and cause the accumulation of lycopene . | NA | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
112,
123
]
} | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
198,
211
]
} |
the second derivative absorption spectra of n-acetyl ethyl esters of phenylalanine , tyrosine and tryptophan , as models of the aromatic amino acid residues in proteins , were measured . | NA | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
69,
82
]
} | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
128,
147
]
} |
the second derivative absorption spectra of n-acetyl ethyl esters of phenylalanine , tyrosine and tryptophan , as models of the aromatic amino acid residues in proteins , were measured . | NA | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
85,
93
]
} | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
128,
147
]
} |
the second derivative absorption spectra of n-acetyl ethyl esters of phenylalanine , tyrosine and tryptophan , as models of the aromatic amino acid residues in proteins , were measured . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
98,
108
]
} | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
128,
147
]
} |
physicochemical investigations of the polymer by means of hydrogen-deuterium exchange , potentiometric titrations , and viscosity measurements indicate a non-ordered , flexible conformation in aqueous solution , depending on ph and salt concentration . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
58,
66
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
67,
76
]
} |
the influence of side group charge of tropomyosin ( tm ) on hydrogen-deuterium exchange kinetics in wet tm films is shown to depend solely on the change in alpha-helix conformational motility with the charge . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
60,
68
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
69,
78
]
} |
the influence of uv-irradiation on the electrical stability of black lipid membranes ( blm ) prepared from mitochondrial lipids has been studied . | NA | {
"id": "C0025249",
"name": "lipid",
"pos": [
69,
74
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
121,
127
]
} |
soluble preparations of horse radish peroxidase are obtained by means of its amino groups modification with glutaric aldehyde , maleic anhydride and inert proteins including albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
155,
163
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
174,
181
]
} |
changes of total blood sugars , glucose , fructose , lactate , pyruvate , acid-base balance and free fatty acids were followed in 15 healthy newborns whose mothers received fructose infusions during labour . | NA | {
"id": "C0005802",
"name": "blood sugars",
"pos": [
17,
29
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
32,
39
]
} |
furthermore , from ph titration and comparison of the native protein with chemically modified bpti , the resonance lines of ala 16 in the active site and ala 58 at the c-terminus were identified . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
61,
68
]
} | {
"id": "C0003641",
"name": "bpti",
"pos": [
94,
98
]
} |
n. europaea cytochrome c-552 belongs to the `` '' bacterial-type '' '' cytochrome c , while t. nouellus cytochrome c-550 resembles eucaryolic cytochrome c . | NA | {
"id": "C1256752",
"name": "-typ",
"pos": [
59,
63
]
} | {
"id": "C0010749",
"name": "c cytochrome",
"pos": [
140,
152
]
} |
when uracil is reacted with formaldehyde and formic acid in dilute aqueous solutions at 100-140 degrees c , 5-hydroxymethyluracil ( 5-hmu ) , methylenebiuracil ( mbu ) and thymine are formed . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
5,
11
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
172,
179
]
} |
in the presence of formic acid , 5-hmu gives mbu , thymine and in some cases uracil . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
51,
58
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
77,
83
]
} |
the dynamics of redistribution of the isoenzymatic spectrum of lactate and malate dehydrogenases in the cells of rat embryo fibroblasts ( ref ) having been in contact with human adenovirus type 12 , as compared to the dynamics of changes in the fine structure of the cellular mitochondria of the same models was studied . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
124,
135
]
} | {
"id": "C0007634",
"name": "structure",
"pos": [
250,
259
]
} |
these disturbances occur from the first days of the ref culture interaction with the oncogenic virus and are not connected with the proliferative growth of the cell culture , but they are stipulated by the very fact of the virus influence on the cell . | NA | {
"id": "C0016030",
"name": "ref",
"pos": [
52,
55
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
246,
250
]
} |
tissue cultivation in the presence of standardized fibrin clot containing plasminogen permitted to reveal and to study quantitatively the relase of the fibrinolysis activators into the medium ( by the amount of the fibrin-fibrinogen degradation products ) . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
51,
57
]
} | {
"id": "C0163275",
"name": "fibrin-fibrinogen",
"pos": [
215,
232
]
} |
the amino-terminal sequences of the chains of activated factor vii were found to be ala-asx-gly- and ile-val-gly- , the same as were earlier observed after activation of factor vii by activated factor x . | NA | {
"id": "C0015505",
"name": "activated factor vii",
"pos": [
46,
66
]
} | {
"id": "C0015502",
"name": "factor vii",
"pos": [
170,
180
]
} |
of 13 initial clinical characteristics , 8 were significantly associated with e+ lymphoblasts : mediastinal enlargement ( 86 % of patients e+ ) , leukocyte counts over 100 x 10 ( 9 ) /liter ( 65 % e+ ) , nodes greater than 2 cm in any diameter ( 65 % e+ ) , age over 5 yr ( 46 % e+ ) , hemoglobin over 8 g/dl ( 44 % e+ ) , hepatomegaly greater than 5 cm ( 38 % e+ ) , boys ( 35 % e+ ) , and lymph node enlargement outside of the cervical area ( 28 % e+ ) . | NA | {
"id": "C0020564",
"name": "enlargement",
"pos": [
108,
119
]
} | {
"id": "C0019209",
"name": "hepatomegaly",
"pos": [
323,
335
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.