text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
immunofluorescence of the separated lymphocytes of four healthy volunteers with antiimmunoglobulins igd and igm produced different distribution profiles for each immunoglobulin class , the igd positive cells migrating faster than the igm positive ones . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
162,
182
]
} | {
"id": "C0020843",
"name": "igd",
"pos": [
189,
192
]
} |
isoprenaline , phenylephrine , adrenaline and noradrenaline at doses ( ed50 ) sufficient to induce muscle relaxation did not always increase the cyclic amp level . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
31,
41
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
46,
59
]
} |
the administration of the drug did not significantly reduce the release of prostaglandins from the denervated kidneys , however , the increase in prostaglandin e-like material , in response to both stimuli , was abolished . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
75,
89
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
146,
161
]
} |
male rats weighing 100 g were assigned to groups and injected daily for 10 days with vehicle ( control ) , 0.4 , 2.0 , 4.0 , 10.0 , or 20.0 mg/kg/day of ethane-1-hydroxy-1,1-diphosphonate ( ehdp ) or dichloromethylene diphosphonate ( c12mdp ) . | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
174,
187
]
} | {
"id": "C0012081",
"name": "dichloromethylene diphosphonate",
"pos": [
200,
231
]
} |
the results show that albumin is more readily extracted from bone pieces than from bone powder which implies that tissue disruption exposes additional protein adsorption sites . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
22,
29
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
151,
158
]
} |
the synthesis , interconversion , and catabolism of purine bases , ribonucleosides , and ribonucleotides in wild-type saccharomyces cerevisiae were studied by measuring the conversion of radioactive adenine , hypoxanthine , guanine , and glycine into acid-soluble purine bases , ribonucleosides , and ribonucleotides , and into nucleic acid adenine and guanine . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
52,
58
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
341,
348
]
} |
the reactions with mannose and mannose-bearing compounds ( yeast mannan , horseradish peroxidase ( ec 1.11.1.7 ) , and serum globulins ) , which are not shared with the galactophilic pseudomonas hemagglutinins , indicate a relationship of the mannose-binding protein of pseudomonas to the plant lectin concanavalin a . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
289,
301
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
302,
316
]
} |
the distribution of stainable iron in the lymph nodes , liver and spleen seven days after intramuscular injection of iron dextran in newborn piglets was comparable to that for oral administration at that stage of the experiment . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
30,
34
]
} | {
"id": "C0022092",
"name": "iron dextran",
"pos": [
117,
129
]
} |
the relationship between plasma phenobarbital concentrations and anticonvulsant activity was determined against seizures induced in epileptic chickens by intermittent photic stimulation ( ips ) . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
112,
120
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
132,
141
]
} |
the excretion pattern of human chorionic gonadotropin ( hcg ) or luteinizing hormone ( lh ) was observed in the urine of 77 patients with trophoblastic neoplasia , 109 with complete remission from trophoblastic neoplasia , and 94 with no trophoblastic neoplasia , when the anti-beta-subunit hcg system radioimmunoassay ( anti-beta-subunit ria ) , which specifically measured hcg was used . | NA | {
"id": "C0106132",
"name": "beta-subunit hcg",
"pos": [
278,
294
]
} | {
"id": "C0018062",
"name": "hcg",
"pos": [
375,
378
]
} |
in a study of 256 non-epithelial neoplasms involving the nasal cavity , paranasal sinuses and nasopharynx , only two lesions were classified as adipose tissue tumors ( one lipoma and one liposarcoma ) . | NA | {
"id": "C0206631",
"name": "adipose tissue",
"pos": [
144,
158
]
} | {
"id": "C0023798",
"name": "lipoma",
"pos": [
172,
178
]
} |
in a continuing study of patients with lymphoproliferative diseases , six adult patients were encountered with a distinctive malignant lymphoma of peripheral t-lymphocyte origin . | NA | {
"id": "C0024314",
"name": "lymphoproliferative diseases",
"pos": [
39,
67
]
} | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
125,
143
]
} |
the acute phase reactants ( alpha-1-antitrypsin , haptoglobin , c3 component of complement and orosomucoid ) varied with the disease status . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
4,
15
]
} | {
"id": "C0002191",
"name": "alpha-1-antitrypsin",
"pos": [
28,
47
]
} |
the acute phase reactants ( alpha-1-antitrypsin , haptoglobin , c3 component of complement and orosomucoid ) varied with the disease status . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
4,
15
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
50,
61
]
} |
the acute phase reactants ( alpha-1-antitrypsin , haptoglobin , c3 component of complement and orosomucoid ) varied with the disease status . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
4,
15
]
} | {
"id": "C0009506",
"name": "c3 component",
"pos": [
64,
76
]
} |
the acute phase reactants ( alpha-1-antitrypsin , haptoglobin , c3 component of complement and orosomucoid ) varied with the disease status . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
4,
15
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
95,
106
]
} |
embryonal tumors were rare as smn and adult-type tumors ( carcinomas ) appeared at earlier than expected ages , whether arising after irradiation or not related to that form of therapy . | NA | {
"id": "C0085183",
"name": "smn",
"pos": [
30,
33
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
49,
55
]
} |
studies of multiple primary neoplasms and their relation to the nervous system should consider two important principles : 1 ) neoplasms of the nervous system have certain unusual features that distinguish them from tumors occurring elsewhere in the body ; | NA | {
"id": "C0027663",
"name": "multiple primary neoplasms",
"pos": [
11,
37
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
215,
221
]
} |
graft-versus-host reaction was prevented by treatment with spleen cells from a second allogeneic strain ( cba ) , followed by cyclophosphamide and syngeneic spleen cells . | NA | {
"id": "C3485979",
"name": "cells",
"pos": [
66,
71
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
164,
169
]
} |
we now show that it is not necessary to use syngeneic spleen cells in the final transplant since h-2-compatible , allogeneic cba cells are as effective . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
61,
66
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
114,
124
]
} |
possible mechanisms for the genesis of common chromosome abnormalities , including isochromosomes and the philadelphia chromosome . | NA | {
"id": "C0008626",
"name": "of",
"pos": [
36,
38
]
} | {
"id": "C0242621",
"name": "isochromosomes",
"pos": [
83,
97
]
} |
syrian hamster embryo fibroblasts transformed in vitro with benzo ( a ) pyrene were analyzed for the presence of type c viral components , including extra- and intracellular reverse transcriptase activity , intracellular type c hamster virus-related rna , and cellular hamster virus group-specific antigen . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
22,
33
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
260,
268
]
} |
the presence of tumor cells consistently increased the colony-forming ability of the endothelial cells , an effect not produced by control-killed cells or 3t3 fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
159,
170
]
} |
measurements of respiration , co2 and lactate production , and changes in the levels of various key metabolites of the glycolytic sequence and tricarboxylic acid cycle were made on five lines of rodent ascites tumor cells ( two strains of ehrlich ascites tumor cells , krebs ii carcinoma , as-30d carcinoma , and l1210 cells ) incubated aerobically in the presence of uniformly labeled d- [ 14c ] glucose . | NA | {
"id": "C0007125",
"name": "ehrlich ascites tumor",
"pos": [
239,
260
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
297,
306
]
} |
the formation of new hair follicles was quantitatively demonstrated in the tail skin of adult mice in the course of a two-stage carcinogenesis experiment with 7,12-dimethylbenz ( a ) anthracene as an initiator and the phorbol ester 12-o-tetradecanoylphorbol-13-acetate as a promoter , as well as in experiments with 12-o-tetradecanoylphorbol-13-acetate alone . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
218,
231
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
316,
352
]
} |
since this lymphoma accounts for about 25 % of all non-hodgkin 's lymphoma patients , this regimen represents a useful tool for the chemotherapist . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
11,
19
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
51,
74
]
} |
the architectural arrangement of the neoplastic cells and their cytologic identification form the histologic basis of the rappaport classification of non-hodgkin 's lymphomas clinical studies have shown the favorable prognosis of the nodular lymphomas while the diffuse lymphomas irrespective of cell type have a poor prognosis . | NA | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
150,
174
]
} | {
"id": "C0024301",
"name": "nodular lymphomas",
"pos": [
234,
251
]
} |
these observations , and the fact that the rate of change of degree of polymerisation of h3po4-swollen cellulose was very slow compared with that effected by the randomly acting endoglucanases ( cx , cm-cellulases ) , indicate that c1 is a cellobiohydrolase . | NA | {
"id": "C0007641",
"name": "endoglucanases",
"pos": [
178,
192
]
} | {
"id": "C1260229",
"name": "cellulases",
"pos": [
203,
213
]
} |
these observations , and the fact that the rate of change of degree of polymerisation of h3po4-swollen cellulose was very slow compared with that effected by the randomly acting endoglucanases ( cx , cm-cellulases ) , indicate that c1 is a cellobiohydrolase . | NA | {
"id": "C1260229",
"name": "cellulases",
"pos": [
203,
213
]
} | {
"id": "C0059939",
"name": "cellobiohydrolase",
"pos": [
240,
257
]
} |
using two-dimensional polyacrylamide gel electrophoresis and well characterized deletion mutants of sv40 that produce proteins of smaller size , we show that these two proteins are , indeed , the virus-coded proteins vp1 and vp3 . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
118,
126
]
} | {
"id": "C0042736",
"name": "virus",
"pos": [
196,
201
]
} |
whereas pretreatment with interferon prior to infection reduces the amount of early sv40 rna , post-infection treatment does not inhibit viral rna synthesis . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
89,
92
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
137,
146
]
} |
molecular weight could be determined using the major fragment ion of m/e ( m+-90 ) in the spectra of ceramides and cerebrosides . | NA | {
"id": "C0007745",
"name": "ceramides",
"pos": [
101,
110
]
} | {
"id": "C0007805",
"name": "cerebrosides",
"pos": [
115,
127
]
} |
in the productive cells , the viral rna sequences are expressed in the poly ( a ) -rich rna fraction . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
30,
39
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
88,
91
]
} |
[ sensitivity of transformed ehsvi fibroblasts to the antibody-complement lytic system . cooperation between the lytic units , and existence of a cellular defense ] . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
35,
46
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
146,
154
]
} |
the localization of intracellular calcitonin has been achieved by immunofluorescence in the cytoplasm of all cells forming the epithelium of the ultimobranchial body of eels , using a human antiserum against synthetic salmon calcitonin i . | NA | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
34,
44
]
} | {
"id": "C0073994",
"name": "synthetic salmon",
"pos": [
208,
224
]
} |
we have previously reported that the addition of plasma from normotensive human subjects to renin-renin substrate inhibits the in vitro rate of angiotensin generation . | NA | {
"id": "C0003017",
"name": "renin",
"pos": [
92,
97
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
144,
155
]
} |
the neutral lipid extract was further separated on silica gel chromatographic plates , and several fractions inhibited renin ( p less than 0.01 ) addition of each of six synthetic neutral lipids to renin-renin substrate did not affect the rate of angiotensin generation . | NA | {
"id": "C0003017",
"name": "renin",
"pos": [
119,
124
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
247,
258
]
} |
the relatively loosely bound apob , extractable by standard buffers , may represent intact low density lipoprotein ( ldl ) and/or very low density lipoprotein ( vldl ) , while the tightly bound fraction may represent insoluble complexes of intact lipoproteins within the plaque or delipidated apob . | NA | {
"id": "C0023825",
"name": "very low density",
"pos": [
130,
146
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
247,
259
]
} |
in a group of twenty-three atopic patients skin tests were performed with the dander allergens of horse , cat and guinea-pig , and with house dust and timothy pollen allergens . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
85,
94
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
136,
146
]
} |
a steady-state kinetic method has been revised for measuring lactate dehydrogenase isoenzyme activities , which relates the inhibition of heart-type isoenzyme activity to the overall isoenzyme composition of the enzyme subunits . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
83,
92
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
212,
218
]
} |
fibroblasts may be advantageous in studies of monoamine oxidase in man by providing both types of enzyme as found , for example , in the central nervous system , and by providing a means of removing many in vivo chemical influences from the cells in culture . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
0,
11
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
241,
246
]
} |
an oral d-xylose tolerance test was carried out on 12 patients with portal liver cirrhosis , on 7 patients with active fatty liver disease and on 29 subjects without liver diseases . | NA | {
"id": "C0015695",
"name": "fatty liver",
"pos": [
119,
130
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
166,
180
]
} |
no significant change in d-xylose excretion was observed in liver cirrhosis or in fatty liver disease . | NA | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
60,
75
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
88,
101
]
} |
culture medium from the fibroblasts of mucolipidosis patients exhibited higher activity of acid hydrolases than medium from cells of patients with gm1-gangliosidosis , fabry 's disease , hurler 's disease , and mannosidosis . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
24,
35
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} |
these cells , however , exhibited somewhat higher levels of enzyme activity in their culture medium than control fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
113,
124
]
} |
this syndrome has also been classified into a 'primary ' form in which there has been no prior pituitary irradiation or surgery , and a 'secondary ' form in which the empty sella is found after such procedures . | NA | {
"id": "C0032002",
"name": "pituitary",
"pos": [
95,
104
]
} | {
"id": "C0014008",
"name": "empty sella",
"pos": [
167,
178
]
} |
tumours were found to differ by their secretory properties , one secreting noradrenaline , the other adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
75,
88
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
101,
111
]
} |
the pharmacokinetics , metabolism , and excretion of aromatically labeled tritiated vincristine ( vcr ) was examined in 4 patients . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
23,
33
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
40,
49
]
} |
a total of 161 patients with chronic obstructive pulmonary disease ( copd ) plus 100 control subjects ( identified during a study of heart disease in 6,860 japanese-american men aged 52 to 75 years who were residing in hawaii ) were analyzed for phenotype in search of the antitrypsin gene z , which has been shown to be associated with pulmonary emphysema in other racial groups . | NA | {
"id": "C0024117",
"name": "chronic obstructive pulmonary disease",
"pos": [
29,
66
]
} | {
"id": "C0034067",
"name": "pulmonary emphysema",
"pos": [
337,
356
]
} |
occurrence of side effect related to plasma diazepam , and anxiolytic effect related to plasma nordiazepam . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
44,
52
]
} | {
"id": "C0011279",
"name": "nordiazepam",
"pos": [
95,
106
]
} |
the pharmacokinetics of 3,3',5,5'-tetrachlorobiphenyl ( 4-cb ) was studied to determine the importance of chlorine position to the kinetics of polychlorinated biphenyl ( pcb ) distribution , metabolism , and excretion by the rat . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
191,
201
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
208,
217
]
} |
the rate of 4-cb metabolism and excretion was slower than would be predicted according to its degree of chlorination . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
17,
27
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
32,
41
]
} |
the inhibition of insulin secretion caused by epinephrine , norepinephrine or phenylephrine via alpha-adrenergic receptors in the pancreas of normal rats was no longer observable with the pancreas from pertussis-sensitized rats . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
46,
57
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
60,
74
]
} |
the distribution , excretion , and possible metabolism of ( 14 ) c- and/or ( 74 ) as-cacodylic acid , an organoarsenical herbicide , was studied in rats following a single intravenous injection , intratracheal instillation or oral gavage . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
19,
28
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
44,
54
]
} |
these results support the hypothesis that chronic , low level , arsenic exposure results in selective inhibition of mitochondrial-bound heme biosynthetic pathway enzymes ( ala synthetase and heme synthetase ) resulting in a substantial increase in urinary porphyrins , uniquely characterized by a greater increase in uroporphyrin than coproporphyrin levels . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
256,
266
]
} | {
"id": "C0042093",
"name": "uroporphyrin",
"pos": [
317,
329
]
} |
these results support the hypothesis that chronic , low level , arsenic exposure results in selective inhibition of mitochondrial-bound heme biosynthetic pathway enzymes ( ala synthetase and heme synthetase ) resulting in a substantial increase in urinary porphyrins , uniquely characterized by a greater increase in uroporphyrin than coproporphyrin levels . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
256,
266
]
} | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
335,
349
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
80,
92
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
95,
102
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
80,
92
]
} | {
"id": "C0040238",
"name": "tin",
"pos": [
114,
117
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
80,
92
]
} | {
"id": "C0032207",
"name": "platinum",
"pos": [
111,
119
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
80,
92
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
122,
126
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
80,
92
]
} | {
"id": "C0039738",
"name": "thallium",
"pos": [
133,
141
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0439879",
"name": "metalloids",
"pos": [
159,
169
]
} | {
"id": "C0003818",
"name": "arsenic",
"pos": [
172,
179
]
} |
details of the kinetics and mechanisms for biomethylation of arsenic are presented , with special emphasis on synergistic reactions between metal and metalloids in different oxidation states . | NA | {
"id": "C0003818",
"name": "arsenic",
"pos": [
61,
68
]
} | {
"id": "C0439879",
"name": "metalloids",
"pos": [
150,
160
]
} |
the chemical bases for such speciation reside in several properties of the arsenicals under consideration : ( 1 ) pentavalent inorganic arsenic , methylarsonic , and cacodylic acid are not extracted from tissue matter made strongly acid with hydrochloric acid , while the corresponding trivalent forms ( as halides ) are extracted ; | NA | {
"id": "C0003819",
"name": "arsenicals",
"pos": [
75,
85
]
} | {
"id": "C0006628",
"name": "cacodylic acid",
"pos": [
166,
180
]
} |
arsenic compounds ( as ( iii ) , as ( v ) , methylarsonic acid and dimethylarsinic acid ) in these samples were analyzed by selective volatilization as arsines with determination of arsenic by plasma excitation emission spectrometry . | NA | {
"id": "C0003819",
"name": "arsenic compounds",
"pos": [
0,
17
]
} | {
"id": "C0006628",
"name": "dimethylarsinic acid",
"pos": [
67,
87
]
} |
the occurrence of possible prolonged alterations in plasma levels of cortisol , epinephrine , norepinephrine , selected energy metabolites , and water and electrolyte balance was assessed in six highly trained male marathon runners by measuring blood biochemical constituents on the 10th day before and for the three days following the running of a marathon . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
80,
91
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
94,
108
]
} |
the majority of small messenger-containing rna molecules in the rna prepared from isolated nuclei are of true nuclear origin , since their frequency distribution differs significantly from that of the polysomal 8 -- 14-s mrna . | NA | {
"id": "C0035696",
"name": "messenger",
"pos": [
22,
31
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
222,
225
]
} |
cyanide binding studies are in agreement with these conclusions and also yield a value of 3.6 x 10 ( 6 ) m-1 s-1 for the intrinsic combination constant of cn- anion with the haem . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
0,
7
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
159,
164
]
} |
absorption was a little better from a polyethylene glycol suppository base than from a triglyceride base . | NA | {
"id": "C0032483",
"name": "polyethylene glycol",
"pos": [
38,
57
]
} | {
"id": "C0980441",
"name": "suppository",
"pos": [
58,
69
]
} |
in previous studies we have demonstrated by the antibody-induced redistribution method that the antisera against these specificities contain antibodies against at least two different polypeptide chains . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
96,
104
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
141,
151
]
} |
rat hepatic bile contains three proteins as major constituents : secretory iga ( siga ) , free secretory component ( fsc ) and albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
32,
40
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
127,
134
]
} |
rat hepatic bile contains three proteins as major constituents : secretory iga ( siga ) , free secretory component ( fsc ) and albumin . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
65,
78
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
95,
114
]
} |
the bile duct daily pours between 5-12 mg each of siga and fsc into the rat duodenum . | NA | {
"id": "C0020838",
"name": "siga",
"pos": [
50,
54
]
} | {
"id": "C0036538",
"name": "fsc",
"pos": [
59,
62
]
} |
fetal mouse livers , days 13 to 19 of gestation , were cultured for 21 days and the culture media tested for erythropoietin ( ep ) , thrombopoietin ( tsf ) and colony stimulating factor ( csf ) . | NA | {
"id": "C0040052",
"name": "thrombopoietin",
"pos": [
133,
147
]
} | {
"id": "C0009392",
"name": "colony stimulating factor",
"pos": [
160,
185
]
} |
these studies indicate that fetal liver cells in culture are capable of producing and/or releasing both ep and csf but not tsf . | NA | {
"id": "C0014822",
"name": "ep",
"pos": [
104,
106
]
} | {
"id": "C0009392",
"name": "csf",
"pos": [
111,
114
]
} |
in rats , unilateral injections of the gaba-derivative baclofen into the zona reticulata of the substantia nigra produced a contralateral rotation that was translated to ipsilateral rotation under the influence of amphetamine . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
39,
43
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
55,
63
]
} |
these results mimic those following unilateral elevation of gaba levels in the substantia nigra and suggest that baclofen may have some gaba agonist activity following intracerebral injection . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
60,
64
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
113,
121
]
} |
by lengthening the hexobarbital-induced sleep probon and amidopyrine change the eeg nature typical of the effect produced by barbiturates . | NA | {
"id": "C0019469",
"name": "hexobarbital",
"pos": [
19,
31
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
125,
137
]
} |
preliminary introduction to rats of alpha-methyl-dopa and 1-dopa abolished the blocking action of reserpine on the renal effects of euphylline . | NA | {
"id": "C0025741",
"name": "alpha-methyl-dopa",
"pos": [
36,
53
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
60,
64
]
} |
dopamine is not merely a precursor of norepinephrine and epinephrine , but performs functions of its own in the organism . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
38,
52
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
57,
68
]
} |
in animals with toxic hepatitis produced by a long-term action of the chemical poison polychlorpinene in a dose of 1/10 dl50 and following introduction to such rats of cholic acid in a dose of 30 mg/100 g an intensified elinination of cholates and cholesterol excretion were evident . | NA | {
"id": "C0055568",
"name": "cholic acid",
"pos": [
168,
179
]
} | {
"id": "C0086003",
"name": "cholates",
"pos": [
235,
243
]
} |
further characterisation of the rna structure in the binding region of protein s4 on 16 s ribosomal rna of escherichia coli . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
32,
35
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
90,
103
]
} |
c3h male and female mice , ingesting 10 ppm of the pesticides heptachlor or heptachlor epoxide in the diet , developed highly significant incidences of carcinomas of the liver . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
62,
72
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
76,
94
]
} |
cortisone , hydrocortisone , triamcinolone , dexamethasone and 9-alpha-fluorohydrocortisone protected against lethality , increased liver glycogen and tt , but only triamcinolone induced liver tp . | NA | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
12,
26
]
} | {
"id": "C0016280",
"name": "9-alpha-fluorohydrocortisone",
"pos": [
63,
91
]
} |
on the purpose of specifying more and more the peculiarity of the isoenzymes mbck in regard to enzyme ck , in the diagnosis as well as in the quantitative evaluation of myocardial infarction , we examined 34 patients hospitalized in u.c.i.c . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
66,
76
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
95,
101
]
} |
in dispersed acinar cells from guinea pig pancreas , cholecystokinin variants ( cck39 and cck33 ) or carboxyl-terminal octapeptide of cholecystokinin ( cck-op ) caused significant increases in outflux of 45ca , cyclic gmp , and release of amylase . | NA | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
53,
68
]
} | {
"id": "C0037167",
"name": "cck-op",
"pos": [
152,
158
]
} |
serial amniotic fluid samples were obtained in the last trimester of pregnancy during the course of 12 uneventful pregnancies . | NA | {
"id": "C0032981",
"name": "last trimester",
"pos": [
51,
65
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
114,
125
]
} |
[ comparative study between dobutamine and other catecholamines in their effects on the cardiac contraction and rhythm ( author 's transl ) ] . | NA | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
28,
38
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
49,
63
]
} |
activity of dob to induce spontaneous contractions of papillary muscle was weakest among these ca . | NA | {
"id": "C0012963",
"name": "dob",
"pos": [
12,
15
]
} | {
"id": "C0007412",
"name": "ca",
"pos": [
95,
97
]
} |
arrhythmogenic activity of dob was weaker than other ca employed both in early stages and 48 hr after coronary ligation . | NA | {
"id": "C0012963",
"name": "dob",
"pos": [
27,
30
]
} | {
"id": "C0007412",
"name": "ca",
"pos": [
53,
55
]
} |
the authors presented 16 cases that displayed episodes of pathological over-eating , i.e . kibarashi-gui ( binge eating ) . | NA | {
"id": "C0020505",
"name": "over-eating",
"pos": [
71,
82
]
} | {
"id": "C0006370",
"name": "binge eating",
"pos": [
107,
119
]
} |
swiss male albino mice were treated subcutaneously with the main cannabinoids ( cbn , cbd , delta9-thc ) at the dosage of 1 mg/kg per day for 30 days , and with the crude resin . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
65,
77
]
} | {
"id": "C0006865",
"name": "cbn",
"pos": [
80,
83
]
} |
swiss male albino mice were treated subcutaneously with the main cannabinoids ( cbn , cbd , delta9-thc ) at the dosage of 1 mg/kg per day for 30 days , and with the crude resin . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
65,
77
]
} | {
"id": "C0039663",
"name": "thc",
"pos": [
99,
102
]
} |
it concerns three more or less circumscribed changes ( differentiated carcinoma of the thyroid , autonomous adenoma and focal thyroiditis ) and two diffuse thyroid conditions ( sub-acute and lymphocytic diffuse thyroiditis , hyperthyroidism ) . | NA | {
"id": "C0040128",
"name": "thyroid",
"pos": [
87,
94
]
} | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
225,
240
]
} |
finally the possibility of ultrasonic targeted percutaneous puncture of the kidneys , tumors and cysts as a diagnostic and occasionally therapeutic approach has to be mentioned . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
86,
92
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
97,
102
]
} |
stimulation of the dopamine-sensitive adenylatecyclase proved to be a good indicator of central dopaminergic receptor stimulation . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
19,
27
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
96,
108
]
} |
this activity , unknown in established mammalian cell lines , resulted in the glycosidic cleavage of both adenosine and the antiviral drug arabinosyladenine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
106,
115
]
} | {
"id": "C0042646",
"name": "arabinosyladenine",
"pos": [
139,
156
]
} |
in the present paper we describe attempts to transfer immunity to syphilis by using spleen cells from chancre-immune rabbits . | NA | {
"id": "C0039128",
"name": "syphilis",
"pos": [
66,
74
]
} | {
"id": "C0007939",
"name": "chancre",
"pos": [
102,
109
]
} |
mice receiving purified endotoxin ( lipopolysaccharide ) exhibited varying degrees of protection , both in terms of increased host survival and the amount of inactivation of the challenge population in vivo . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
24,
33
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
36,
54
]
} |
amino acids could be divided into two groups based on their effect on the relative rates of recovery : those amino acids ( leucine and cystine ) that are precursors of protein only , and amino acids ( glutamate/glutamine or lysine ) that are incorporated into both protein and cell wall peptidoglycan . | NA | {
"id": "C0033665",
"name": "precursors",
"pos": [
154,
164
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
265,
272
]
} |
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