text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
immunofluorescence of the separated lymphocytes of four healthy volunteers with antiimmunoglobulins igd and igm produced different distribution profiles for each immunoglobulin class , the igd positive cells migrating faster than the igm positive ones . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
162,
182
]
} | {
"id": "C0020843",
"name": "igd",
"pos": [
189,
192
]
} |
isoprenaline , phenylephrine , adrenaline and noradrenaline at doses ( ed50 ) sufficient to induce muscle relaxation did not always increase the cyclic amp level . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
31,
41
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
46,
59
]
} |
the administration of the drug did not significantly reduce the release of prostaglandins from the denervated kidneys , however , the increase in prostaglandin e-like material , in response to both stimuli , was abolished . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
75,
89
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
146,
161
]
} |
male rats weighing 100 g were assigned to groups and injected daily for 10 days with vehicle ( control ) , 0.4 , 2.0 , 4.0 , 10.0 , or 20.0 mg/kg/day of ethane-1-hydroxy-1,1-diphosphonate ( ehdp ) or dichloromethylene diphosphonate ( c12mdp ) . | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
174,
187
]
} | {
"id": "C0012081",
"name": "dichloromethylene diphosphonate",
"pos": [
200,
231
]
} |
the results show that albumin is more readily extracted from bone pieces than from bone powder which implies that tissue disruption exposes additional protein adsorption sites . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
22,
29
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
151,
158
]
} |
the synthesis , interconversion , and catabolism of purine bases , ribonucleosides , and ribonucleotides in wild-type saccharomyces cerevisiae were studied by measuring the conversion of radioactive adenine , hypoxanthine , guanine , and glycine into acid-soluble purine bases , ribonucleosides , and ribonucleotides , a... | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
52,
58
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
341,
348
]
} |
the reactions with mannose and mannose-bearing compounds ( yeast mannan , horseradish peroxidase ( ec 1.11.1.7 ) , and serum globulins ) , which are not shared with the galactophilic pseudomonas hemagglutinins , indicate a relationship of the mannose-binding protein of pseudomonas to the plant lectin concanavalin a . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
289,
301
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
302,
316
]
} |
the distribution of stainable iron in the lymph nodes , liver and spleen seven days after intramuscular injection of iron dextran in newborn piglets was comparable to that for oral administration at that stage of the experiment . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
30,
34
]
} | {
"id": "C0022092",
"name": "iron dextran",
"pos": [
117,
129
]
} |
the relationship between plasma phenobarbital concentrations and anticonvulsant activity was determined against seizures induced in epileptic chickens by intermittent photic stimulation ( ips ) . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
112,
120
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
132,
141
]
} |
the excretion pattern of human chorionic gonadotropin ( hcg ) or luteinizing hormone ( lh ) was observed in the urine of 77 patients with trophoblastic neoplasia , 109 with complete remission from trophoblastic neoplasia , and 94 with no trophoblastic neoplasia , when the anti-beta-subunit hcg system radioimmunoassay (... | NA | {
"id": "C0106132",
"name": "beta-subunit hcg",
"pos": [
278,
294
]
} | {
"id": "C0018062",
"name": "hcg",
"pos": [
375,
378
]
} |
in a study of 256 non-epithelial neoplasms involving the nasal cavity , paranasal sinuses and nasopharynx , only two lesions were classified as adipose tissue tumors ( one lipoma and one liposarcoma ) . | NA | {
"id": "C0206631",
"name": "adipose tissue",
"pos": [
144,
158
]
} | {
"id": "C0023798",
"name": "lipoma",
"pos": [
172,
178
]
} |
in a continuing study of patients with lymphoproliferative diseases , six adult patients were encountered with a distinctive malignant lymphoma of peripheral t-lymphocyte origin . | NA | {
"id": "C0024314",
"name": "lymphoproliferative diseases",
"pos": [
39,
67
]
} | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
125,
143
]
} |
the acute phase reactants ( alpha-1-antitrypsin , haptoglobin , c3 component of complement and orosomucoid ) varied with the disease status . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
4,
15
]
} | {
"id": "C0002191",
"name": "alpha-1-antitrypsin",
"pos": [
28,
47
]
} |
the acute phase reactants ( alpha-1-antitrypsin , haptoglobin , c3 component of complement and orosomucoid ) varied with the disease status . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
4,
15
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
50,
61
]
} |
the acute phase reactants ( alpha-1-antitrypsin , haptoglobin , c3 component of complement and orosomucoid ) varied with the disease status . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
4,
15
]
} | {
"id": "C0009506",
"name": "c3 component",
"pos": [
64,
76
]
} |
the acute phase reactants ( alpha-1-antitrypsin , haptoglobin , c3 component of complement and orosomucoid ) varied with the disease status . | NA | {
"id": "C0001347",
"name": "acute phase",
"pos": [
4,
15
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
95,
106
]
} |
embryonal tumors were rare as smn and adult-type tumors ( carcinomas ) appeared at earlier than expected ages , whether arising after irradiation or not related to that form of therapy . | NA | {
"id": "C0085183",
"name": "smn",
"pos": [
30,
33
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
49,
55
]
} |
studies of multiple primary neoplasms and their relation to the nervous system should consider two important principles : 1 ) neoplasms of the nervous system have certain unusual features that distinguish them from tumors occurring elsewhere in the body ; | NA | {
"id": "C0027663",
"name": "multiple primary neoplasms",
"pos": [
11,
37
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
215,
221
]
} |
graft-versus-host reaction was prevented by treatment with spleen cells from a second allogeneic strain ( cba ) , followed by cyclophosphamide and syngeneic spleen cells . | NA | {
"id": "C3485979",
"name": "cells",
"pos": [
66,
71
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
164,
169
]
} |
we now show that it is not necessary to use syngeneic spleen cells in the final transplant since h-2-compatible , allogeneic cba cells are as effective . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
61,
66
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
114,
124
]
} |
possible mechanisms for the genesis of common chromosome abnormalities , including isochromosomes and the philadelphia chromosome . | NA | {
"id": "C0008626",
"name": "of",
"pos": [
36,
38
]
} | {
"id": "C0242621",
"name": "isochromosomes",
"pos": [
83,
97
]
} |
syrian hamster embryo fibroblasts transformed in vitro with benzo ( a ) pyrene were analyzed for the presence of type c viral components , including extra- and intracellular reverse transcriptase activity , intracellular type c hamster virus-related rna , and cellular hamster virus group-specific antigen . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
22,
33
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
260,
268
]
} |
the presence of tumor cells consistently increased the colony-forming ability of the endothelial cells , an effect not produced by control-killed cells or 3t3 fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
159,
170
]
} |
measurements of respiration , co2 and lactate production , and changes in the levels of various key metabolites of the glycolytic sequence and tricarboxylic acid cycle were made on five lines of rodent ascites tumor cells ( two strains of ehrlich ascites tumor cells , krebs ii carcinoma , as-30d carcinoma , and l1210 c... | NA | {
"id": "C0007125",
"name": "ehrlich ascites tumor",
"pos": [
239,
260
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
297,
306
]
} |
the formation of new hair follicles was quantitatively demonstrated in the tail skin of adult mice in the course of a two-stage carcinogenesis experiment with 7,12-dimethylbenz ( a ) anthracene as an initiator and the phorbol ester 12-o-tetradecanoylphorbol-13-acetate as a promoter , as well as in experiments with 12-o... | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
218,
231
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
316,
352
]
} |
since this lymphoma accounts for about 25 % of all non-hodgkin 's lymphoma patients , this regimen represents a useful tool for the chemotherapist . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
11,
19
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
51,
74
]
} |
the architectural arrangement of the neoplastic cells and their cytologic identification form the histologic basis of the rappaport classification of non-hodgkin 's lymphomas clinical studies have shown the favorable prognosis of the nodular lymphomas while the diffuse lymphomas irrespective of cell type have a poor pr... | NA | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
150,
174
]
} | {
"id": "C0024301",
"name": "nodular lymphomas",
"pos": [
234,
251
]
} |
these observations , and the fact that the rate of change of degree of polymerisation of h3po4-swollen cellulose was very slow compared with that effected by the randomly acting endoglucanases ( cx , cm-cellulases ) , indicate that c1 is a cellobiohydrolase . | NA | {
"id": "C0007641",
"name": "endoglucanases",
"pos": [
178,
192
]
} | {
"id": "C1260229",
"name": "cellulases",
"pos": [
203,
213
]
} |
these observations , and the fact that the rate of change of degree of polymerisation of h3po4-swollen cellulose was very slow compared with that effected by the randomly acting endoglucanases ( cx , cm-cellulases ) , indicate that c1 is a cellobiohydrolase . | NA | {
"id": "C1260229",
"name": "cellulases",
"pos": [
203,
213
]
} | {
"id": "C0059939",
"name": "cellobiohydrolase",
"pos": [
240,
257
]
} |
using two-dimensional polyacrylamide gel electrophoresis and well characterized deletion mutants of sv40 that produce proteins of smaller size , we show that these two proteins are , indeed , the virus-coded proteins vp1 and vp3 . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
118,
126
]
} | {
"id": "C0042736",
"name": "virus",
"pos": [
196,
201
]
} |
whereas pretreatment with interferon prior to infection reduces the amount of early sv40 rna , post-infection treatment does not inhibit viral rna synthesis . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
89,
92
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
137,
146
]
} |
molecular weight could be determined using the major fragment ion of m/e ( m+-90 ) in the spectra of ceramides and cerebrosides . | NA | {
"id": "C0007745",
"name": "ceramides",
"pos": [
101,
110
]
} | {
"id": "C0007805",
"name": "cerebrosides",
"pos": [
115,
127
]
} |
in the productive cells , the viral rna sequences are expressed in the poly ( a ) -rich rna fraction . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
30,
39
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
88,
91
]
} |
[ sensitivity of transformed ehsvi fibroblasts to the antibody-complement lytic system . cooperation between the lytic units , and existence of a cellular defense ] . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
35,
46
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
146,
154
]
} |
the localization of intracellular calcitonin has been achieved by immunofluorescence in the cytoplasm of all cells forming the epithelium of the ultimobranchial body of eels , using a human antiserum against synthetic salmon calcitonin i . | NA | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
34,
44
]
} | {
"id": "C0073994",
"name": "synthetic salmon",
"pos": [
208,
224
]
} |
we have previously reported that the addition of plasma from normotensive human subjects to renin-renin substrate inhibits the in vitro rate of angiotensin generation . | NA | {
"id": "C0003017",
"name": "renin",
"pos": [
92,
97
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
144,
155
]
} |
the neutral lipid extract was further separated on silica gel chromatographic plates , and several fractions inhibited renin ( p less than 0.01 ) addition of each of six synthetic neutral lipids to renin-renin substrate did not affect the rate of angiotensin generation . | NA | {
"id": "C0003017",
"name": "renin",
"pos": [
119,
124
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
247,
258
]
} |
the relatively loosely bound apob , extractable by standard buffers , may represent intact low density lipoprotein ( ldl ) and/or very low density lipoprotein ( vldl ) , while the tightly bound fraction may represent insoluble complexes of intact lipoproteins within the plaque or delipidated apob . | NA | {
"id": "C0023825",
"name": "very low density",
"pos": [
130,
146
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
247,
259
]
} |
in a group of twenty-three atopic patients skin tests were performed with the dander allergens of horse , cat and guinea-pig , and with house dust and timothy pollen allergens . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
85,
94
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
136,
146
]
} |
a steady-state kinetic method has been revised for measuring lactate dehydrogenase isoenzyme activities , which relates the inhibition of heart-type isoenzyme activity to the overall isoenzyme composition of the enzyme subunits . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
83,
92
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
212,
218
]
} |
fibroblasts may be advantageous in studies of monoamine oxidase in man by providing both types of enzyme as found , for example , in the central nervous system , and by providing a means of removing many in vivo chemical influences from the cells in culture . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
0,
11
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
241,
246
]
} |
an oral d-xylose tolerance test was carried out on 12 patients with portal liver cirrhosis , on 7 patients with active fatty liver disease and on 29 subjects without liver diseases . | NA | {
"id": "C0015695",
"name": "fatty liver",
"pos": [
119,
130
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
166,
180
]
} |
no significant change in d-xylose excretion was observed in liver cirrhosis or in fatty liver disease . | NA | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
60,
75
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
88,
101
]
} |
culture medium from the fibroblasts of mucolipidosis patients exhibited higher activity of acid hydrolases than medium from cells of patients with gm1-gangliosidosis , fabry 's disease , hurler 's disease , and mannosidosis . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
24,
35
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} |
these cells , however , exhibited somewhat higher levels of enzyme activity in their culture medium than control fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
113,
124
]
} |
this syndrome has also been classified into a 'primary ' form in which there has been no prior pituitary irradiation or surgery , and a 'secondary ' form in which the empty sella is found after such procedures . | NA | {
"id": "C0032002",
"name": "pituitary",
"pos": [
95,
104
]
} | {
"id": "C0014008",
"name": "empty sella",
"pos": [
167,
178
]
} |
tumours were found to differ by their secretory properties , one secreting noradrenaline , the other adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
75,
88
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
101,
111
]
} |
the pharmacokinetics , metabolism , and excretion of aromatically labeled tritiated vincristine ( vcr ) was examined in 4 patients . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
23,
33
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
40,
49
]
} |
a total of 161 patients with chronic obstructive pulmonary disease ( copd ) plus 100 control subjects ( identified during a study of heart disease in 6,860 japanese-american men aged 52 to 75 years who were residing in hawaii ) were analyzed for phenotype in search of the antitrypsin gene z , which has been shown to be... | NA | {
"id": "C0024117",
"name": "chronic obstructive pulmonary disease",
"pos": [
29,
66
]
} | {
"id": "C0034067",
"name": "pulmonary emphysema",
"pos": [
337,
356
]
} |
occurrence of side effect related to plasma diazepam , and anxiolytic effect related to plasma nordiazepam . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
44,
52
]
} | {
"id": "C0011279",
"name": "nordiazepam",
"pos": [
95,
106
]
} |
the pharmacokinetics of 3,3',5,5'-tetrachlorobiphenyl ( 4-cb ) was studied to determine the importance of chlorine position to the kinetics of polychlorinated biphenyl ( pcb ) distribution , metabolism , and excretion by the rat . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
191,
201
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
208,
217
]
} |
the rate of 4-cb metabolism and excretion was slower than would be predicted according to its degree of chlorination . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
17,
27
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
32,
41
]
} |
the inhibition of insulin secretion caused by epinephrine , norepinephrine or phenylephrine via alpha-adrenergic receptors in the pancreas of normal rats was no longer observable with the pancreas from pertussis-sensitized rats . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
46,
57
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
60,
74
]
} |
the distribution , excretion , and possible metabolism of ( 14 ) c- and/or ( 74 ) as-cacodylic acid , an organoarsenical herbicide , was studied in rats following a single intravenous injection , intratracheal instillation or oral gavage . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
19,
28
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
44,
54
]
} |
these results support the hypothesis that chronic , low level , arsenic exposure results in selective inhibition of mitochondrial-bound heme biosynthetic pathway enzymes ( ala synthetase and heme synthetase ) resulting in a substantial increase in urinary porphyrins , uniquely characterized by a greater increase in uro... | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
256,
266
]
} | {
"id": "C0042093",
"name": "uroporphyrin",
"pos": [
317,
329
]
} |
these results support the hypothesis that chronic , low level , arsenic exposure results in selective inhibition of mitochondrial-bound heme biosynthetic pathway enzymes ( ala synthetase and heme synthetase ) resulting in a substantial increase in urinary porphyrins , uniquely characterized by a greater increase in uro... | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
256,
266
]
} | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
335,
349
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
80,
92
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
95,
102
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
80,
92
]
} | {
"id": "C0040238",
"name": "tin",
"pos": [
114,
117
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
80,
92
]
} | {
"id": "C0032207",
"name": "platinum",
"pos": [
111,
119
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
80,
92
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
122,
126
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
80,
92
]
} | {
"id": "C0039738",
"name": "thallium",
"pos": [
133,
141
]
} |
methylcobalamin ( methyl-b12 ) has been implicated in the biomethylation of the heavy metals ( mercury , tin , platinum , gold , and thallium ) as well as the metalloids ( arsenic , selenium , tellurium and sulfur ) . | NA | {
"id": "C0439879",
"name": "metalloids",
"pos": [
159,
169
]
} | {
"id": "C0003818",
"name": "arsenic",
"pos": [
172,
179
]
} |
details of the kinetics and mechanisms for biomethylation of arsenic are presented , with special emphasis on synergistic reactions between metal and metalloids in different oxidation states . | NA | {
"id": "C0003818",
"name": "arsenic",
"pos": [
61,
68
]
} | {
"id": "C0439879",
"name": "metalloids",
"pos": [
150,
160
]
} |
the chemical bases for such speciation reside in several properties of the arsenicals under consideration : ( 1 ) pentavalent inorganic arsenic , methylarsonic , and cacodylic acid are not extracted from tissue matter made strongly acid with hydrochloric acid , while the corresponding trivalent forms ( as halides ) are... | NA | {
"id": "C0003819",
"name": "arsenicals",
"pos": [
75,
85
]
} | {
"id": "C0006628",
"name": "cacodylic acid",
"pos": [
166,
180
]
} |
arsenic compounds ( as ( iii ) , as ( v ) , methylarsonic acid and dimethylarsinic acid ) in these samples were analyzed by selective volatilization as arsines with determination of arsenic by plasma excitation emission spectrometry . | NA | {
"id": "C0003819",
"name": "arsenic compounds",
"pos": [
0,
17
]
} | {
"id": "C0006628",
"name": "dimethylarsinic acid",
"pos": [
67,
87
]
} |
the occurrence of possible prolonged alterations in plasma levels of cortisol , epinephrine , norepinephrine , selected energy metabolites , and water and electrolyte balance was assessed in six highly trained male marathon runners by measuring blood biochemical constituents on the 10th day before and for the three day... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
80,
91
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
94,
108
]
} |
the majority of small messenger-containing rna molecules in the rna prepared from isolated nuclei are of true nuclear origin , since their frequency distribution differs significantly from that of the polysomal 8 -- 14-s mrna . | NA | {
"id": "C0035696",
"name": "messenger",
"pos": [
22,
31
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
222,
225
]
} |
cyanide binding studies are in agreement with these conclusions and also yield a value of 3.6 x 10 ( 6 ) m-1 s-1 for the intrinsic combination constant of cn- anion with the haem . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
0,
7
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
159,
164
]
} |
absorption was a little better from a polyethylene glycol suppository base than from a triglyceride base . | NA | {
"id": "C0032483",
"name": "polyethylene glycol",
"pos": [
38,
57
]
} | {
"id": "C0980441",
"name": "suppository",
"pos": [
58,
69
]
} |
in previous studies we have demonstrated by the antibody-induced redistribution method that the antisera against these specificities contain antibodies against at least two different polypeptide chains . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
96,
104
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
141,
151
]
} |
rat hepatic bile contains three proteins as major constituents : secretory iga ( siga ) , free secretory component ( fsc ) and albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
32,
40
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
127,
134
]
} |
rat hepatic bile contains three proteins as major constituents : secretory iga ( siga ) , free secretory component ( fsc ) and albumin . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
65,
78
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
95,
114
]
} |
the bile duct daily pours between 5-12 mg each of siga and fsc into the rat duodenum . | NA | {
"id": "C0020838",
"name": "siga",
"pos": [
50,
54
]
} | {
"id": "C0036538",
"name": "fsc",
"pos": [
59,
62
]
} |
fetal mouse livers , days 13 to 19 of gestation , were cultured for 21 days and the culture media tested for erythropoietin ( ep ) , thrombopoietin ( tsf ) and colony stimulating factor ( csf ) . | NA | {
"id": "C0040052",
"name": "thrombopoietin",
"pos": [
133,
147
]
} | {
"id": "C0009392",
"name": "colony stimulating factor",
"pos": [
160,
185
]
} |
these studies indicate that fetal liver cells in culture are capable of producing and/or releasing both ep and csf but not tsf . | NA | {
"id": "C0014822",
"name": "ep",
"pos": [
104,
106
]
} | {
"id": "C0009392",
"name": "csf",
"pos": [
111,
114
]
} |
in rats , unilateral injections of the gaba-derivative baclofen into the zona reticulata of the substantia nigra produced a contralateral rotation that was translated to ipsilateral rotation under the influence of amphetamine . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
39,
43
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
55,
63
]
} |
these results mimic those following unilateral elevation of gaba levels in the substantia nigra and suggest that baclofen may have some gaba agonist activity following intracerebral injection . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
60,
64
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
113,
121
]
} |
by lengthening the hexobarbital-induced sleep probon and amidopyrine change the eeg nature typical of the effect produced by barbiturates . | NA | {
"id": "C0019469",
"name": "hexobarbital",
"pos": [
19,
31
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
125,
137
]
} |
preliminary introduction to rats of alpha-methyl-dopa and 1-dopa abolished the blocking action of reserpine on the renal effects of euphylline . | NA | {
"id": "C0025741",
"name": "alpha-methyl-dopa",
"pos": [
36,
53
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
60,
64
]
} |
dopamine is not merely a precursor of norepinephrine and epinephrine , but performs functions of its own in the organism . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
38,
52
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
57,
68
]
} |
in animals with toxic hepatitis produced by a long-term action of the chemical poison polychlorpinene in a dose of 1/10 dl50 and following introduction to such rats of cholic acid in a dose of 30 mg/100 g an intensified elinination of cholates and cholesterol excretion were evident . | NA | {
"id": "C0055568",
"name": "cholic acid",
"pos": [
168,
179
]
} | {
"id": "C0086003",
"name": "cholates",
"pos": [
235,
243
]
} |
further characterisation of the rna structure in the binding region of protein s4 on 16 s ribosomal rna of escherichia coli . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
32,
35
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
90,
103
]
} |
c3h male and female mice , ingesting 10 ppm of the pesticides heptachlor or heptachlor epoxide in the diet , developed highly significant incidences of carcinomas of the liver . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
62,
72
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
76,
94
]
} |
cortisone , hydrocortisone , triamcinolone , dexamethasone and 9-alpha-fluorohydrocortisone protected against lethality , increased liver glycogen and tt , but only triamcinolone induced liver tp . | NA | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
12,
26
]
} | {
"id": "C0016280",
"name": "9-alpha-fluorohydrocortisone",
"pos": [
63,
91
]
} |
on the purpose of specifying more and more the peculiarity of the isoenzymes mbck in regard to enzyme ck , in the diagnosis as well as in the quantitative evaluation of myocardial infarction , we examined 34 patients hospitalized in u.c.i.c . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
66,
76
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
95,
101
]
} |
in dispersed acinar cells from guinea pig pancreas , cholecystokinin variants ( cck39 and cck33 ) or carboxyl-terminal octapeptide of cholecystokinin ( cck-op ) caused significant increases in outflux of 45ca , cyclic gmp , and release of amylase . | NA | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
53,
68
]
} | {
"id": "C0037167",
"name": "cck-op",
"pos": [
152,
158
]
} |
serial amniotic fluid samples were obtained in the last trimester of pregnancy during the course of 12 uneventful pregnancies . | NA | {
"id": "C0032981",
"name": "last trimester",
"pos": [
51,
65
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
114,
125
]
} |
[ comparative study between dobutamine and other catecholamines in their effects on the cardiac contraction and rhythm ( author 's transl ) ] . | NA | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
28,
38
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
49,
63
]
} |
activity of dob to induce spontaneous contractions of papillary muscle was weakest among these ca . | NA | {
"id": "C0012963",
"name": "dob",
"pos": [
12,
15
]
} | {
"id": "C0007412",
"name": "ca",
"pos": [
95,
97
]
} |
arrhythmogenic activity of dob was weaker than other ca employed both in early stages and 48 hr after coronary ligation . | NA | {
"id": "C0012963",
"name": "dob",
"pos": [
27,
30
]
} | {
"id": "C0007412",
"name": "ca",
"pos": [
53,
55
]
} |
the authors presented 16 cases that displayed episodes of pathological over-eating , i.e . kibarashi-gui ( binge eating ) . | NA | {
"id": "C0020505",
"name": "over-eating",
"pos": [
71,
82
]
} | {
"id": "C0006370",
"name": "binge eating",
"pos": [
107,
119
]
} |
swiss male albino mice were treated subcutaneously with the main cannabinoids ( cbn , cbd , delta9-thc ) at the dosage of 1 mg/kg per day for 30 days , and with the crude resin . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
65,
77
]
} | {
"id": "C0006865",
"name": "cbn",
"pos": [
80,
83
]
} |
swiss male albino mice were treated subcutaneously with the main cannabinoids ( cbn , cbd , delta9-thc ) at the dosage of 1 mg/kg per day for 30 days , and with the crude resin . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
65,
77
]
} | {
"id": "C0039663",
"name": "thc",
"pos": [
99,
102
]
} |
it concerns three more or less circumscribed changes ( differentiated carcinoma of the thyroid , autonomous adenoma and focal thyroiditis ) and two diffuse thyroid conditions ( sub-acute and lymphocytic diffuse thyroiditis , hyperthyroidism ) . | NA | {
"id": "C0040128",
"name": "thyroid",
"pos": [
87,
94
]
} | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
225,
240
]
} |
finally the possibility of ultrasonic targeted percutaneous puncture of the kidneys , tumors and cysts as a diagnostic and occasionally therapeutic approach has to be mentioned . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
86,
92
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
97,
102
]
} |
stimulation of the dopamine-sensitive adenylatecyclase proved to be a good indicator of central dopaminergic receptor stimulation . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
19,
27
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
96,
108
]
} |
this activity , unknown in established mammalian cell lines , resulted in the glycosidic cleavage of both adenosine and the antiviral drug arabinosyladenine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
106,
115
]
} | {
"id": "C0042646",
"name": "arabinosyladenine",
"pos": [
139,
156
]
} |
in the present paper we describe attempts to transfer immunity to syphilis by using spleen cells from chancre-immune rabbits . | NA | {
"id": "C0039128",
"name": "syphilis",
"pos": [
66,
74
]
} | {
"id": "C0007939",
"name": "chancre",
"pos": [
102,
109
]
} |
mice receiving purified endotoxin ( lipopolysaccharide ) exhibited varying degrees of protection , both in terms of increased host survival and the amount of inactivation of the challenge population in vivo . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
24,
33
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
36,
54
]
} |
amino acids could be divided into two groups based on their effect on the relative rates of recovery : those amino acids ( leucine and cystine ) that are precursors of protein only , and amino acids ( glutamate/glutamine or lysine ) that are incorporated into both protein and cell wall peptidoglycan . | NA | {
"id": "C0033665",
"name": "precursors",
"pos": [
154,
164
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
265,
272
]
} |
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