text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
binding levels of dnp were as high as those with the two acyclic n-nitrosamines dmn and den , but binding levels of npy and npd were lower . | NA | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
67,
79
]
} | {
"id": "C0027253",
"name": "npy",
"pos": [
116,
119
]
} |
spleen cells were separated on nylon wool , sephadex g-10 columns , or plastic petri dishes and tested for activity in the cytostasis assay or for cytotoxicity against 51cr-labeled lymphoma target cells . | NA | {
"id": "C0028736",
"name": "nylon",
"pos": [
31,
36
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
71,
78
]
} |
the processing of newly replicated concatameric t5 dna into both single stranded dna changed of unit length and single-stranded fragments of sizes comparable to those found in mature t5 virion dna occurs in the absence of late t5 protein synthesis . | NA | {
"id": "C0012935",
"name": "dna",
"pos": [
51,
54
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
193,
196
]
} |
contour-length measurements of both nondenatured and partially denatured dna from purified extracellular human cytomegalovirus indicate that more than one size class of viral dna is encapsidated . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
73,
76
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
169,
178
]
} |
the linear dna was obtained by complete cleavage of closed circular dna with hae ii or bam hi endonuclease or partial cleavage with either hae iii endonuclease or nuclease s1 , followed , in some cases , by mild digestion with phage lambda 5 ' -exonuclease . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
11,
14
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
59,
71
]
} |
the linear dna was obtained by complete cleavage of closed circular dna with hae ii or bam hi endonuclease or partial cleavage with either hae iii endonuclease or nuclease s1 , followed , in some cases , by mild digestion with phage lambda 5 ' -exonuclease . | NA | {
"id": "C0019243",
"name": "hae",
"pos": [
77,
80
]
} | {
"id": "C1857728",
"name": "hae iii",
"pos": [
139,
146
]
} |
the 108s material contained viral proteins f , g , h , and d , and the relative amounts of these proteins in the 108s material were similar to those in the infectious 132s particle , which has previously been described as a possible intermediate in the assembly of 114s phage particles . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
28,
42
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
97,
105
]
} |
the tryptic peptides of the fragments overlap with corresponding peptides in protein hp1 , but not with the peptides of protein hp3 , showing that cistron 8 codes for the major head protein hp1 . | NA | {
"id": "C0030935",
"name": "peptides",
"pos": [
12,
20
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
108,
116
]
} |
viral complementary dna ( cdna ) sequences corresponding to the gag , pol , env , src , and c regions of the rous sarcoma virus genome were selected by hybridizing viral cdna to rna from viruses that lack the env or src gene or to polyadenylic acid [ poly ( a ) ] -containing rna fragments of different lengths and isolating either hybridized or unhybridized dna . | NA | {
"id": "C0012939",
"name": "viral",
"pos": [
0,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
359,
362
]
} |
analyses of virus-specific rna , using the specific cdna 's as molecular probes , demonstrated that oncovirus-infected cells contained genome-length ( 30-40s ) rna plus either one or two species of subgenome-length viral rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
27,
30
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
215,
224
]
} |
( iv ) the endogenous viral rna in uninfected cells and the rna from rous-associated virus-0 virions hybridized only partially with dna complementary to the common region of the rous-associated virus-2 genome , whereas the rna of all exogenous viruses tested hybridized almost completely to this complementary dna . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
22,
31
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
223,
226
]
} |
[ studies on the effect of herpes virus infections on human cell-mediated immunity . 1. lymphocyte subpopulations in the peripheral blood from patients with herpes zoster and herpes simplex ( author 's transl ) ] . | NA | {
"id": "C0019372",
"name": "herpes virus infections",
"pos": [
27,
50
]
} | {
"id": "C0019360",
"name": "herpes zoster",
"pos": [
157,
170
]
} |
[ studies on the effect of herpes virus infections on human cell-mediated immunity . 1. lymphocyte subpopulations in the peripheral blood from patients with herpes zoster and herpes simplex ( author 's transl ) ] . | NA | {
"id": "C0019372",
"name": "herpes virus infections",
"pos": [
27,
50
]
} | {
"id": "C0019348",
"name": "herpes simplex",
"pos": [
175,
189
]
} |
one of the factors causing changes in the renal transport of electrolytes postflight could have been an alteration in the ionic composition of the serum , especially a decrease in the potassium concentration and an increase in the calcium and magnesium content . | NA | {
"id": "C0013832",
"name": "electrolytes",
"pos": [
61,
73
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
122,
127
]
} |
the na+-dependent accumulation of alpha-aminoisobutyric acid ( aib ) , measured in normal growing and quiescent ( serum-deprived ) hswp cells ( human diploid fibroblast ) , was found to be twofold higher ( aib/in/aibout = 20-25 ) under the normal growing conditions . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
136,
141
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
158,
168
]
} |
isolation and purification of bacterial membrane proteins by the use of organic solvents : the lactose permease and the carbodiimide-reactive protein of the adenosinetriphosphatase complex of escherichia coli . | NA | {
"id": "C0004627",
"name": "bacterial",
"pos": [
30,
39
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
142,
149
]
} |
the heterophile antigen ( paul-bunnell antigen , pba ) of infectious mononucleosis was isolated by extraction of an aqueous suspension of bovine erythrocyte stromata with chloroform-methanol ( 2:1 ) . | NA | {
"id": "C0003333",
"name": "heterophile antigen",
"pos": [
4,
23
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
39,
46
]
} |
on sds-polyacrylamide gel electrophoresis , it migrated as a single component that stained for protein with coomassie blue , for carbohydrate with periodic acid-schiff reagent , and for lipid with oil red 0 ; | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
186,
191
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
197,
200
]
} |
effects of heavy metals ( cadmium , copper , chromium and lead ) on a freshwater snail : biomphalaria glabrata say ( gastropoda , prosobranchia ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
11,
23
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
26,
33
]
} |
effects of heavy metals ( cadmium , copper , chromium and lead ) on a freshwater snail : biomphalaria glabrata say ( gastropoda , prosobranchia ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
11,
23
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
36,
42
]
} |
effects of heavy metals ( cadmium , copper , chromium and lead ) on a freshwater snail : biomphalaria glabrata say ( gastropoda , prosobranchia ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
11,
23
]
} | {
"id": "C0008574",
"name": "chromium",
"pos": [
45,
53
]
} |
effects of heavy metals ( cadmium , copper , chromium and lead ) on a freshwater snail : biomphalaria glabrata say ( gastropoda , prosobranchia ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
11,
23
]
} | {
"id": "C0023175",
"name": "lead",
"pos": [
58,
62
]
} |
this study concerns the effects of heavy metals ( cadmium , copper and chromium ) on the mortality and fecundity of the adults of biomphalaria glabrata and the viability of their embryos . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
35,
47
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
50,
57
]
} |
this study concerns the effects of heavy metals ( cadmium , copper and chromium ) on the mortality and fecundity of the adults of biomphalaria glabrata and the viability of their embryos . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
35,
47
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
60,
66
]
} |
this study concerns the effects of heavy metals ( cadmium , copper and chromium ) on the mortality and fecundity of the adults of biomphalaria glabrata and the viability of their embryos . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
35,
47
]
} | {
"id": "C0008574",
"name": "chromium",
"pos": [
71,
79
]
} |
a retrospective study of respiratory distress in a special-care baby unit revealed that transient tachypnoea of the newborn ( t.t.n.b . ) lasting more than 24 h was as common as the respiratory distress syndrome ( r.d.s . ) . | NA | {
"id": "C0158940",
"name": "transient tachypnoea of the newborn",
"pos": [
88,
123
]
} | {
"id": "C0035220",
"name": "respiratory distress syndrome",
"pos": [
182,
211
]
} |
several clinical reports suggest allergy as a causative or associated factor in the etiology of meniere 's disease or endolymphatic hydrops . | NA | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
96,
114
]
} | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
118,
139
]
} |
the combination of hyperglycemia and hyperinsulinemia suggested that insulin resistance had developed in these rats , and this was confirmed by demonstrating that the hypoglycemic effect of exogenously administered insulin was attenuated in rats following bilateral ureterotomy as compared to sham-operated rats . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
37,
53
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
69,
87
]
} |
natural electron acceptors tested , such as nad , fmn , riboflavin , and cytochrome c , had no effect on the reaction rate . | NA | {
"id": "C0016388",
"name": "fmn",
"pos": [
50,
53
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
56,
66
]
} |
the response was less impressive for cobined hyperlipidaemia and hypertriglyceridaemia ( about one-half attained normal values in four to six weeks ) , possibly owing to insufficient time for adequate weight loss to have occurred . | NA | {
"id": "C0020473",
"name": "hyperlipidaemia",
"pos": [
45,
60
]
} | {
"id": "C0020557",
"name": "hypertriglyceridaemia",
"pos": [
65,
86
]
} |
these data confirm the high prevalence of hyperlipidaemia in middleaged australians and suggest the simple dietary conselling will frequently correct hypercholesterolaemia at least in the short term . | NA | {
"id": "C0020473",
"name": "hyperlipidaemia",
"pos": [
42,
57
]
} | {
"id": "C0020443",
"name": "hypercholesterolaemia",
"pos": [
150,
171
]
} |
it contains five amino acids : arginine , lysine , glycine , alanine and glutamic acid which make together 74 % of all amino acid residues . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
51,
58
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
119,
129
]
} |
it contains five amino acids : arginine , lysine , glycine , alanine and glutamic acid which make together 74 % of all amino acid residues . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
61,
68
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
119,
129
]
} |
alanine and isoleucine synthetases show sigmoidal kinetics with respect to amino acid concentration and have hill coefficients of 1.21 and 1.40 respectively . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
75,
85
]
} |
hla typing in families with hemochromatosis could provide a means of early detection of subjects at risk before appearance of any sign of iron overload . | NA | {
"id": "C0018995",
"name": "hemochromatosis",
"pos": [
28,
43
]
} | {
"id": "C0282193",
"name": "iron overload",
"pos": [
138,
151
]
} |
loading with l-cysteine hydrochloride and l-methionine further increased the excretion of sulfite and thiosulfate , but not inorganic sulfate excretion . | NA | {
"id": "C0039950",
"name": "thiosulfate",
"pos": [
102,
113
]
} | {
"id": "C0038720",
"name": "inorganic sulfate",
"pos": [
124,
141
]
} |
increased levels of serotonin ( 5-ht ) , 5-hydroxyindoleacetic acid ( 5-hiaa ) and tryptophan as well as enhanced accumulation of 5-hydroxytryptophan , induced by decarboxylase inhibition were also observed . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
83,
93
]
} | {
"id": "C0000578",
"name": "hydroxytryptophan",
"pos": [
132,
149
]
} |
although hormonal stimulation of the enzyme was diminished in toxin-treated membranes , the hormone receptors were still functionally active as revealed after addition of gpp ( nh ) p , gtp or gtpgammas . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
171,
183
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
193,
196
]
} |
although hormonal stimulation of the enzyme was diminished in toxin-treated membranes , the hormone receptors were still functionally active as revealed after addition of gpp ( nh ) p , gtp or gtpgammas . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
186,
189
]
} | {
"id": "C0079469",
"name": "gtpgammas",
"pos": [
193,
202
]
} |
whereas gtp behaves as an antagonist ( or a partial agonist with low intrinsic activity ) compared to gpp ( nh ) p in control membranes , it has similar intrinsic activity as gpp ( nh ) p in the toxin-treated membranes . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
8,
11
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
102,
114
]
} |
none of the antigens , revealed in mammary carcinomas and human milk seems to be either viral structural , or virus-induced cellular antigen . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
12,
20
]
} | {
"id": "C0003342",
"name": "virus",
"pos": [
110,
115
]
} |
5 of prl secreting adenoma , 5 of gh secreting adenoma , 7 of so-called non-functioning pituitary adenoma , 5 of tuberculum sellae meningioma and 3 of craniopharyngioma , were studied in relation to the size of suprasellar extension measured by our own method on pneumoencephalograms . | NA | {
"id": "C0033375",
"name": "prl secreting adenoma",
"pos": [
5,
26
]
} | {
"id": "C0001430",
"name": "adenoma",
"pos": [
98,
105
]
} |
after treatment , chenodeoxycholic acid was the main bile acid and there was a significant fall in cholic and deoxycholic acid . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
18,
39
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
110,
126
]
} |
liver disease ( steatosis and cirrhosis ) 6 months after bypass , together with cholesterol lithiasis in 2/6 patients . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
0,
13
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
30,
39
]
} |
a three-hour radioimmunoassay ( ria ) for serum hcg with a sensitivity of 5 mlu/ml was developed which utilizes an antiserum generated against the beta subunit of hcg , 125i-hcg for tracer purposes , a highly purified hcg standard , and dioxane for separation of bound from free hormone . | NA | {
"id": "C0106132",
"name": "beta subunit",
"pos": [
147,
159
]
} | {
"id": "C0018062",
"name": "hcg",
"pos": [
218,
221
]
} |
mature infants had no severe jaundice ( more than 16 mg/100 ml ) and the resolution of hyperbilirubinemia was more rapid . | NA | {
"id": "C0022346",
"name": "jaundice",
"pos": [
29,
37
]
} | {
"id": "C0020433",
"name": "hyperbilirubinemia",
"pos": [
87,
105
]
} |
the successive differentiation in the series lymphocyte -- ( lymphocyte-type cell -- precursor ) -- weakly differentiated cell ( polyblast ) -- profibroblast -- fibroblast was shown by means of scanning and transmission electron microscopy . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
77,
81
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
161,
171
]
} |
the collagen fibers run from the surface of the differentiated fibroblasts in the ground substance and preserve the direction of their growth with respect to the spatial position of cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
63,
74
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
182,
187
]
} |
the level of intermediates of glycolysis ( hexose monophosphates , fructose-1,6-diphosphate , pyruvate ) and the rate of lactic acid synthesis ( under the aerobic conditions without substrates and in the presence of glucose , glucose-6-phosphate and fructose-1,6-diphosphate ) were measured in the eye tissues ( retina , iris , ciliary bodies , uvea ) of rabbits of different age . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
43,
49
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
250,
258
]
} |
a basic question in eeg feedback training of epileptic patients is whether the decrease in seizures is specifically due to the training or to other factors . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
45,
54
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
91,
99
]
} |
differences were found among the three birth-weight groups , with the children of low birth weight scoring significantly lower than the groups of medium and high birth weight . | NA | {
"id": "C0005612",
"name": "birth-weight",
"pos": [
39,
51
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
168,
174
]
} |
the renal toxicity of aminoglycosides more recent than gentamicin has not yet been fully explored , the same applying to their use in association with cefalotin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
22,
37
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
55,
65
]
} |
trna phee , coli was labeled with the n-hydroxysuccinimide esters of 1-dimethylaminonaphthalene-5-sulfonyl glycine and n-methylanthranilic acid through reaction with the amino acid moiety of its x-base , whereby yields of 66 % and 24 % , respectively , were obtained . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
107,
114
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
170,
180
]
} |
assuming the ylide mechanism of exchange reaction it is suggested that the lower rate of 1h leads to 3h exchange in c ( 8 ) h-groups of purinic residues in polynucleotides of a-form ( rna and other polyribonucleotides ) as compared to those of b-form ( dna and other polydeoxyribonucleotides ) might be accounted for by decreased availability of c ( 8 ) h-groups for oh-ions of the solvent due to a different microenviroment of these groups in a- and b-type helixes . | NA | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
156,
171
]
} | {
"id": "C0032590",
"name": "polyribonucleotides",
"pos": [
198,
217
]
} |
assuming the ylide mechanism of exchange reaction it is suggested that the lower rate of 1h leads to 3h exchange in c ( 8 ) h-groups of purinic residues in polynucleotides of a-form ( rna and other polyribonucleotides ) as compared to those of b-form ( dna and other polydeoxyribonucleotides ) might be accounted for by decreased availability of c ( 8 ) h-groups for oh-ions of the solvent due to a different microenviroment of these groups in a- and b-type helixes . | NA | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
156,
171
]
} | {
"id": "C0032468",
"name": "polydeoxyribonucleotides",
"pos": [
267,
291
]
} |
rates of the synthesis of the trnas and small rrnas after irradiation with various doses of uv light were determined by pulse labeling and quantitation of the rna species after twodimensional gel electrophoreses . | NA | {
"id": "C0035701",
"name": "rrnas",
"pos": [
46,
51
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
159,
162
]
} |
ribo- and 2'-deoxyribonucleoside 5'-di- or triphosphates are commonly synthesized by reaction of inorganic phosphate or pyrophosphate with phosphorimidazolidates obtained by reaction of nucleoside 5'-phosphates with 1,1'-carbonyldiimidazole . | NA | {
"id": "C0011528",
"name": "deoxyribonucleoside",
"pos": [
13,
32
]
} | {
"id": "C0028621",
"name": "nucleoside",
"pos": [
186,
196
]
} |
anti-dpaptpa and anti-dpapapt antisera were found to contain antibodies which were highly specific to the respective hapten sequence . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
30,
38
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
61,
71
]
} |
insertion of uracil for thymine at site 13 ( our nomenclature ) significantly reduced the dissociation half-life of qx86 repressor for lac operator dna ( 21 vs 1.2 min ) . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
13,
19
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
24,
31
]
} |
the minor form of valine trna from baker 's yeast-trnaval 2b -- purified by column chromatography was completely digested with guanylo-rnase and pancreatic rnase . | NA | {
"id": "C0014241",
"name": "rnase",
"pos": [
135,
140
]
} | {
"id": "C0035541",
"name": "pancreatic rnase",
"pos": [
145,
161
]
} |
the halves of trna val 2b were prepared by partial digestion with pancreatic rnase , and their complete guanylo-rnase and pancreatic rnase digests were analysed . | NA | {
"id": "C0014241",
"name": "rnase",
"pos": [
77,
82
]
} | {
"id": "C0035541",
"name": "pancreatic rnase",
"pos": [
122,
138
]
} |
in the case of a short-acting barbiturate , hexobarbital , this effect appears in normotensive rats only if the barbiturate is given 60 min prior to hydralazine administration . | NA | {
"id": "C0019469",
"name": "hexobarbital",
"pos": [
44,
56
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
112,
123
]
} |
excretion of d-glucaric acid and metabolism of salicylamide in man : the effect of phenobarbital-produced enzymatic induction . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
0,
9
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
33,
43
]
} |
the influence of several compounds activating or producing hypofunction of the serotonergic system was studied on the convulsive threshold and anticonvulsive action of benzodiazepines ( chlordiazepoxide , diazepam , oxazepam , nitrazepam ) in the pentylenetetrazol test . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
168,
183
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
186,
202
]
} |
elution with various concentrations of sodium chloride in tris-hcl buffer ( ph 8.0 , 0.01 m ) resulted in fractions that were rich in either secretory immunoglobulin a ( siga ) ( 0.1 m nacl ) or free secretory component ( sc ) ( 0.05 m nacl ) . | NA | {
"id": "C0020838",
"name": "secretory immunoglobulin a",
"pos": [
141,
167
]
} | {
"id": "C0036538",
"name": "secretory",
"pos": [
200,
209
]
} |
repeated fractionation on this column resulted in a single purified fraction , which contained very high siga activity and showed immunological cross-reaction with both sc and serum iga . | NA | {
"id": "C0020838",
"name": "siga",
"pos": [
105,
109
]
} | {
"id": "C0036538",
"name": "sc",
"pos": [
169,
171
]
} |
separate determination of hydrocortisone and corticosterone in the blood of patients with the hypercorticism symptom-complex showed that elevation of the corticosteroid concentration could occur on account of similar elevation of the concentration of both hormones , or one of the hormones alone . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
154,
168
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
281,
289
]
} |
deuterium-exchanged rhodopsin , in which the schiff base hydrogen is replaced by a deuterium , also shows a marked non-arrhenius temperature dependence at low temperatures , consistent with tunneling . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
57,
65
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
83,
92
]
} |
therefore , we postulate that mu dna replicates in situ and the replication generates a form of mu dna active in the integrative recombination between mu dna and host dna . | NA | {
"id": "C0000702",
"name": "a form",
"pos": [
86,
92
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
167,
170
]
} |
the cisa-dna complex ( separated from free cistron a protein ) , upon the addition of escherichia coli rep protein , atp , and dna binding protein , is unwound to generate a single-stranded linear [ presumably the nicked ( + ) strand ] and a circular [ presumably the ( - ) strand ] molecule . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
53,
60
]
} | {
"id": "C0012940",
"name": "dna binding protein",
"pos": [
127,
146
]
} |
to elucidate the basis for these differences , we isolated mrna from induced human fibroblasts and lymphoblastoid ( namalva ) cells and studied the products of translation in xenopus laevis oocytes . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
83,
94
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
126,
131
]
} |
according to this mechanism gtp should activate the toxin-treated preparation of adenylate cyclase , as does the hydrolysis-resistant analog guanosine 5'- ( beta , gamma-immino ) triphosphate [ gpp ( nh ) p ] . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
28,
31
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
194,
206
]
} |
indeed , the toxin-treated adenylate cyclase was maximally activated , in the presence of isoproternol , by either gtp or gpp ( nh ) p , while adenylate cyclase not treated with toxin was stimulated by hormone plus gtp to only one-fifth of the activity achieved with hormone plus gpp ( nh ) p . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
115,
118
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
122,
134
]
} |
the native enzyme , however , was refractory to propranolol only if activated by gpp ( nh ) p but not by gtp . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
81,
93
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
105,
108
]
} |
moreover , the synergism described here between colchicine-like agents and hormones is of potential therapeutic importance in clinical conditions in which either alkaloid or hormone has been useful separately . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
48,
58
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
162,
170
]
} |
furthermore , in the fibroblast cultures derived from cells previously maintained in 10 mum pge ( 2 ) for 14 days , pge ( 2 ) had no effect on dna synthesis , indicating that the pge ( 2 ) -sensitive cells had disappeared from the cultures . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
21,
31
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
200,
205
]
} |
to determine whether any of the missing proteins represent the mutant gene product two experimental approaches have been applied . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
40,
48
]
} | {
"id": "C1564139",
"name": "mutant gene product",
"pos": [
63,
82
]
} |
analysis of revertants of pf1 gave evidence ( altered map positions ) that protein 4 is the mutant gene product . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
75,
82
]
} | {
"id": "C1564139",
"name": "mutant gene product",
"pos": [
92,
111
]
} |
saturated fatty acids such as stearic and arachidic acids had no effect on the guanylate cyclase activity in the presence or absence of lipoxidase , indicating that human plateletguanylate cyclase is stimulated by unsaturated fatty acid peroxides rather than by fatty acids . | NA | {
"id": "C0013724",
"name": "arachidic acids",
"pos": [
42,
57
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
262,
273
]
} |
saturated fatty acids such as stearic and arachidic acids had no effect on the guanylate cyclase activity in the presence or absence of lipoxidase , indicating that human plateletguanylate cyclase is stimulated by unsaturated fatty acid peroxides rather than by fatty acids . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
214,
236
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
262,
273
]
} |
immunoglobulin obtained from the serum of rabbits immunized with a highly purified preparation of estradiol-receptor complex from calf uterine nuclei has been shown to contain specific antibodies to the receptor protein ( estrophilin ) by four criteria : ( a ) precipitation of the radioactive steroid upon addition of goat antibody against rabbit gamma globulin to a mixture of the tritiated estradiol-receptor complex and the immunoglobulin , ( b ) adsorption of the estradiol-receptor complex by the immunoglobulin linked to sepharose , ( c ) adsorption of the estradiol-receptor complex in the presence of the immunoglobulin by staphylococcus aureus protein-a linked to sepharose , and ( d ) the ability of the immunoglobulin to increase the sedimentation rate of the estradiol-receptor complex . | NA | {
"id": "C0017007",
"name": "gamma globulin",
"pos": [
348,
362
]
} | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
715,
729
]
} |
to investigate whether this enrichment of ss-dna in transcribed dna sequences involves provirus dna , radioactive amv rna and cdna copies of amv rna were used . | NA | {
"id": "C0012935",
"name": "ss-dna",
"pos": [
42,
48
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
127,
130
]
} |
most of the 70s amv rna hybridized much faster to ss-dna from productively infected leukemic cells than to bulk dna . | NA | {
"id": "C0012935",
"name": "ss-dna",
"pos": [
50,
56
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
112,
115
]
} |
this was confirmed by the fact that relatively insignificant amounts of the ss-cdna molecules made in the presence of actinomycin d could be annealed to ss-dna as compared with bulk dna . | NA | {
"id": "C0012935",
"name": "ss-dna",
"pos": [
153,
159
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
182,
185
]
} |
electron microscopy was used to study the formation of random complexes between escherichia coli rna polymerase ( nucleosidetriphosphate : rna nucleotidyltransferase , ec 2.7.7.6 ) and a promoterless fragment ( mbo i-c ) of bacteriophage t7 dna , and to determine the location of the polymerase molecules bound at 3 degrees to the promoter-containing ( hinf ) 1100 fragment of the same dna . | NA | {
"id": "C0035681",
"name": "rna polymerase",
"pos": [
97,
111
]
} | {
"id": "C0035673",
"name": "rna",
"pos": [
139,
142
]
} |
after addition of prostaglandin f2alpha ( pgf2alpha ) and insulin to quiescent cultured 3t3 fibroblasts a constant lag phase of 15 hr occurs before an increased rate of cellular exit from g1 is observed . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
92,
103
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
169,
177
]
} |
we found for each of the patients that the alpha/beta mrna sequence ratio was more nearly normal in the nuclear rna than in either cytoplasmic or reticulocyte rna . | NA | {
"id": "C0035700",
"name": "nuclear",
"pos": [
104,
111
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
159,
162
]
} |
the dna of the f plasmid is joined to bacterial dna sequences in the f ' orf203 by directly repeated insertion sequence 2 ( is2 ) elements . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
4,
7
]
} | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
38,
51
]
} |
the immune response to beta-galactosidase ( beta-d-galactoside galactohydrolase ; ec 3.2.1.23 ) is characterized by a wave of early help followed by a wave of suppression to a subsequent in vitro challenge with galactosidase-fluorescein . | NA | {
"id": "C0005220",
"name": "beta-galactosidase",
"pos": [
23,
41
]
} | {
"id": "C0016955",
"name": "galactosidase",
"pos": [
211,
224
]
} |
these data indicate that one small region of an antigen , capable of activating suppressors , can nullify the positive effect induced in helper t cells reactive with other epitopes on beta-galactosidase . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
48,
55
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
172,
180
]
} |
these findings , together with the known potent aldosterone stimulating effect of angiotensin iii and its presence in rat plasma , suggest that this heptapeptide could be the physiologically important steroidogenic angiotensin in this species . | NA | {
"id": "C0003012",
"name": "angiotensin iii",
"pos": [
82,
97
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
215,
226
]
} |
on the actions of noradrenaline , adrenaline and isopropyl noradrenaline on the arterial blood pressure , heart rate and muscle blood flow in man . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
18,
31
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
62,
72
]
} |
a comparison of the actions of noradrenaline and adrenaline on the blood vessels of human skeletal muscle . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
31,
44
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
49,
59
]
} |
the effect of the peroxide concentration and other factors on the decomposition of hydrogen peroxide by catalase . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
18,
26
]
} | {
"id": "C0020281",
"name": "hydrogen peroxide",
"pos": [
83,
100
]
} |
recent chemical studies have indicated that in this process the aldehyde group of retinene ( 1 ) is reduced to the primary alcohol group of vitamin a ( 1 ) ( morton ; wald ) . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
64,
72
]
} | {
"id": "C0035331",
"name": "retinene",
"pos": [
82,
90
]
} |
effect of urea , thiourea , phenylthiourea and thiouracil on the oxygen consumption of blocked and active embryonic cells . | NA | {
"id": "C0039958",
"name": "thiourea",
"pos": [
17,
25
]
} | {
"id": "C0031505",
"name": "phenylthiourea",
"pos": [
28,
42
]
} |
biochemical , cytological and pathological studies of basal cell epithelioma might lead to a clearer understanding of the nature of epitheliomas in general . | NA | {
"id": "C0007117",
"name": "basal cell epithelioma",
"pos": [
54,
76
]
} | {
"id": "C0007097",
"name": "epitheliomas",
"pos": [
132,
144
]
} |
metabolism of uric acid , glutathione and nitrogen , and excretion of 11-oxysteroids and 17-ketosteroids during induction of diabetes in man with pituitary adrenocorticotropic hormone . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
0,
10
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
57,
66
]
} |
on the utilization of exogenous sulfate sulfur by the rat in the formation of ethereal sulfates as indicated by the use of sodium sulfate labeled with radioactive sulfur . | NA | {
"id": "C0038720",
"name": "sulfates",
"pos": [
87,
95
]
} | {
"id": "C0074769",
"name": "sodium sulfate",
"pos": [
123,
137
]
} |
vaso- and broncho-motor actions of noradrenaline ( arterenol ) and of adrenaline in the isolated perfused lungs of the dog . | NA | {
"id": "C0028351",
"name": "arterenol",
"pos": [
51,
60
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
70,
80
]
} |
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