text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
even though ischemia developed during the occlusion , no decline in the adenylate ( atp + adp + amp ) or creatine ( pcr + cr ) pools occurred after the clamp was released , and the energy charge of the adenine nucleotides remained unchanged . | NA | {
"id": "C0031634",
"name": "pcr",
"pos": [
116,
119
]
} | {
"id": "C0010286",
"name": "cr",
"pos": [
122,
124
]
} |
the methaemoglobin content in the blood of the propositus was 17.8 % and isoelectric focusing analysis on a polyacrylamide gel plate showed that the haemoglobin consisted of 65.2 % oxyhaemoglobin ( alpha 2+ beta 2+ ) 2 , 29.6 % half-oxidized forms , 20.9 % ( alpha 3+ beta 2+ ) 2 and 8.7 % ( alpha 2+ beta 3+ ) 2 , and 3... | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
7,
18
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
337,
351
]
} |
to decide between these two possibilities , we prepared ( ca2+ + mg2+ ) -atpase from erythrocytes of normal ( aa ) , sickle cell trait ( as ) and sickle cell disease ( ss ) individuals . | NA | {
"id": "C0037054",
"name": "sickle cell trait",
"pos": [
117,
134
]
} | {
"id": "C0002895",
"name": "sickle cell disease",
"pos": [
146,
165
]
} |
haemoglobin values rose in the second trimester in european pregnancies associated with poor growth , whereas the values fell in the asian pregnancies both with well grown and poorly grown fetuses . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
31,
47
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
139,
150
]
} |
results of experiments with guinea-pig inclusion conjunctivitis as an animal model show that under laboratory conditions flies can readily transmit this chlamydial ocular infection from one animal to another . | NA | {
"id": "C0009770",
"name": "inclusion",
"pos": [
39,
48
]
} | {
"id": "C0008149",
"name": "chlamydial",
"pos": [
153,
163
]
} |
it is a small protein released by a subset of mature t cells following lectin-antigen activation , which in turn acts upon other t-cell subsets that have developed specific receptors for tcgf after lectin-antigen stimulation . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
14,
21
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
198,
204
]
} |
this inhibitor did not affect factor xi activation or the activity of preformed factor xia . | NA | {
"id": "C0015522",
"name": "factor xi",
"pos": [
30,
39
]
} | {
"id": "C0015524",
"name": "factor xia",
"pos": [
80,
90
]
} |
pwm-treated tg- cells showed no significant cfu-c suppressor activity , whereas pwm-treated total t and tg+ cells inhibited colony formation of both autologous and allogeneic marrow cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
16,
21
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
164,
174
]
} |
although we confirmed that hmw kininogen , bovine serum albumin , fibrinogen , cold insoluble globulin , and mixed phospholipids apparently increased prekallikrein activation , we found that the product of prekallikrein activation ( kallikrein ) lost substantial activity in less than 0.5 min after exposure to a variety... | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
150,
163
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
233,
243
]
} |
evidence of continuing hospital admissions of patients with asian rickets and osteomalacia led to a further attempt to provide more effective preventive measures for the glasgow asian community . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
66,
73
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
78,
90
]
} |
when gastric emptying is slow the absorption of alcohol is delayed and peak blood alcohol concentrations are reduced . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
48,
55
]
} | {
"id": "C0684262",
"name": "blood",
"pos": [
76,
81
]
} |
in this retrospective study , the degree of differentiation of atypical lymphoid cells was assessed in pretreatment cutaneous biopsy specimens from 248 patients with cutaneous t-cell lymphomas ( mycosis fungoides and sezary syndrome ) and the findings were correlated with the subsequent therapeutic results . | NA | {
"id": "C0079773",
"name": "cutaneous t-cell lymphomas",
"pos": [
166,
192
]
} | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
217,
232
]
} |
unfavorable prognostic features were poor differentiation of the tumor , lack of histologic evidence of radiation-induced regression of the tumor , and more than three neck lymph node metastases in the initial neck dissection . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
65,
70
]
} | {
"id": "C0027666",
"name": "radiation-induced",
"pos": [
104,
121
]
} |
ultrastructure was correlated with the content of immunoreactive insulin ( iri ) and the percentage of proinsulin-like component ( plc ) in the serum , tumors , and culture fluid . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
65,
72
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
103,
113
]
} |
high levels of iri in the serum and a high percentage of plc in the serum and tumor , found in a patient with a virtually agranular tumor , combined with the fact of rare occurrence of emiocytosis , suggest a defective insulin storage mechanism and alternative routes of insulin release in insulinoma cells . | NA | {
"id": "C0033362",
"name": "plc",
"pos": [
57,
60
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
290,
297
]
} |
sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the immune complexes formed by reacting spent medium of cultured melanoma cells with xenoantiserum 8986 showed that the antiserum contains antibodies reacting with a m.w . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
74,
90
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
209,
219
]
} |
sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the immune complexes formed by reacting spent medium of cultured melanoma cells with xenoantiserum 8986 showed that the antiserum contains antibodies reacting with a m.w . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
159,
168
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
209,
219
]
} |
addition of cations to cytosols also promoted the rapid appearance of this second ionic form of receptor . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
12,
19
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
82,
87
]
} |
the influence of normal human lung fibroblasts ( nlf ) on the clonal growth of human prostatic carcinoma cells ( pc-3 ) in soft agar was studied . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
35,
46
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
105,
110
]
} |
effects of anchored nlf ( proliferating cell monolayer ) and nonanchored nlf ( nonproliferating cells embedded in agar ) on pc-3 growth were compared . | NA | {
"id": "C0016030",
"name": "nlf",
"pos": [
20,
23
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
96,
101
]
} |
the toxic and mutagenic effects of n-methyl-n'-nitro-n-nitrosoguanidine on ruba 7e cells were studied and are similar to those reported for diploid human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
83,
88
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
154,
165
]
} |
unlike human fibroblasts , in which the recovery of 6-thioguanine-resistant mutants is reduced by contact feeding when the inoculum size during selection is increased above 10 ( 4 ) cells per p60 dish , 5 to 10 x 10 ( 4 ) ruba 7e cells can be plated per p60 dish without reducing mutant recovery . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
230,
235
]
} |
furthermore , the binding and the biological action of proinsulin were about 2 % that of native insulin in the two cell lines studied . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
55,
65
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
96,
103
]
} |
the uptake of radioactive putrescine and spermidine by the transformed cells was faster than that of the normal controls . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
26,
36
]
} | {
"id": "C0037871",
"name": "transformed",
"pos": [
59,
70
]
} |
the amount of radioactive putrescine and polyamines taken up by the transformed cells also exceeded that observed with normal fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
80,
85
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
126,
137
]
} |
after 24 hr , 38 % of the sites remained in the bloom 's syndrome cells in comparison with 16 % in normal fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
66,
71
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
106,
117
]
} |
recovery of immunologically reactive antibodies and antigens from breast cancer immune complexes by preparative isoelectric focusing . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
37,
47
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
80,
96
]
} |
type i procollagen mrna activity measured in rna from nine of the lines by an in vitro translation assay also decreased with increasing severity of transformation . | NA | {
"id": "C0035696",
"name": "mrna",
"pos": [
19,
23
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
45,
48
]
} |
pancreatic carcinogenesis appeared to be enhanced in two groups which were fed diets containing 20 % corn oil , i.e. , high in unsaturated fat ; | NA | {
"id": "C0010029",
"name": "corn oil",
"pos": [
101,
109
]
} | {
"id": "C0012172",
"name": "unsaturated fat",
"pos": [
127,
142
]
} |
analysis of the nucleotide content of tumors reveals comparable spectrums of purine and pyrimidine nucleotide levels in the ll/o and ll/pala-c lines , whereas the ll/pala-j line has augmented nucleotide pools . | NA | {
"id": "C0034288",
"name": "pyrimidine nucleotide",
"pos": [
88,
109
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
192,
202
]
} |
to study whether this is a phenomenon related to malignant transformation , the release of surface macromolecules by human and murine melanoma cells was compared to that by normal allogeneic cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
143,
148
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
180,
196
]
} |
likewise in mice , the release of labeled surface macromolecules by b16 melanoma cells ( 36 % in 3 hr ) was no faster than that by normal syngeneic fibroblasts ( 56 % in 3 hr ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
81,
86
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
148,
159
]
} |
seven days after the final intubation of oh-bbn , animals were fed either a placebo diet or a diet supplemented with the following retinoids : for rats , 0.8 mmol 13-cis-retinoic acid , 2 mmol n- ( ethyl ) -all-trans-retinamide , or 2 mmol n- ( 2-hydroxyethyl ) -all-trans-retinamide per kg diet ; | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
131,
140
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic acid",
"pos": [
163,
183
]
} |
excision repair of uv damage in human cells was measured by the incorporation of new bases into dna after exposure to uv light and variety of other carcinogens including x-rays , furocoumarins plus 360 nm light ( 8-methoxypsoralen ( 8-mop ) , 4'-aminomethyl 4,5',8-trimethylpsoralen hydrochloride ( amt ) and angelicin )... | NA | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
179,
192
]
} | {
"id": "C0025684",
"name": "8-methoxypsoralen",
"pos": [
213,
230
]
} |
the availability of pure anhydro-araic 3'-acetate made possible a comparative study of the antineoplastic , antiviral and biochemical potencies of anhydro-araic 3'-acetate with the structurally related agents 2,2'-anhydro-1- ( 3'-o-acetyl-beta-d-arabinofuranosyl ) cytosine ( anhydro-arac 3'-acetate ) and 2,2'-anhydro-1... | NA | {
"id": "C0010711",
"name": "arabinofuranosyl ) cytosine",
"pos": [
246,
273
]
} | {
"id": "C0010557",
"name": "anhydro-arac",
"pos": [
276,
288
]
} |
this was approached by measuring deuterium incorporation into chloroform and 2-chloro-1,1,1-trifluoroethane formed as microsomal metabolites of carbon tetrachloride and halothane , respectively , in a medium enriched in deuterium oxide . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
33,
42
]
} | {
"id": "C0011745",
"name": "deuterium oxide",
"pos": [
220,
235
]
} |
this paper describes the in vitro interaction between benzopyrene and steroids at the level of two rat liver monooxygenases : steroid-16 alpha-hydroxylase and aryl hydrocarbon hydroxylase ( ahh ) . | NA | {
"id": "C0038311",
"name": "steroids",
"pos": [
70,
78
]
} | {
"id": "C0072084",
"name": "steroid-16 alpha-hydroxylase",
"pos": [
126,
154
]
} |
( 2 ) ahh is supported by two cytochrome p-450 forms : a specific form which is inducible by methylcholanthrene and inhibited in vitro by alpha-naphthoflavone , but is insensitive to metyrapone and steroids ; | NA | {
"id": "C0003927",
"name": "ahh",
"pos": [
6,
9
]
} | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
30,
46
]
} |
after 2 h perfusion caffeine was extensively metabolized mainly to dimethyl and monomethyl xanthines , a minor pathway to 1,3,7-trimethyluric acid was also seen . | NA | {
"id": "C0006644",
"name": "caffeine",
"pos": [
20,
28
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
91,
100
]
} |
at na/polynucleotide ratio of 0.15 and nucleic acids concentration 100 microgram/ml the numbers of drug molecules bound per 10 ( 3 ) nucleotides were about 10 -- 13 for native calf thymus dna , 19 -- 28 for denatured dna and 23 -- 36 for rna . | NA | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
6,
20
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
133,
144
]
} |
at na/polynucleotide ratio of 0.15 and nucleic acids concentration 100 microgram/ml the numbers of drug molecules bound per 10 ( 3 ) nucleotides were about 10 -- 13 for native calf thymus dna , 19 -- 28 for denatured dna and 23 -- 36 for rna . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
39,
52
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
217,
220
]
} |
administration of saralasin , an angiotensin ii antagonist , not only prevented the compensation in ap , but also significantly magnified the maximal hypotensive response seen following d ( ch2 ) 5vdavp ( group 4 ) . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
18,
27
]
} | {
"id": "C0003009",
"name": "angiotensin",
"pos": [
33,
44
]
} |
from additional studies with purine-substituted ( n6-methyl-adenosine , n6-phenylisopropyl-adenosine ) and ribose-substituted ( 2'-deoxy-adenosine and arabino-furanosyl-adenine ) adenosine analogues , we conclude that adenosine may inhibit the inotropic responses to hormones as well as the adenylate cyclase activity by... | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
29,
35
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
169,
176
]
} |
when alpha receptors were blocked , isoproterenol and epinephrine had similar vasodilator activity , and when beta receptors were blocked , epinephrine and norepinephrine had marked vasoconstrictor activity . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
54,
65
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
156,
170
]
} |
when a diastolic sound or murmur is best heard apically , even if accompanied by a systolic murmur , mitral valve prolapse should be considered . | NA | {
"id": "C0018808",
"name": "murmur",
"pos": [
26,
32
]
} | {
"id": "C0232257",
"name": "systolic murmur",
"pos": [
83,
98
]
} |
we examined the effects of temperature on the activity and steady-state kinetics of aspartate aminotransferase ( ec 2.6.1.1 ) , using purified human soluble ( s-aspat ) and mitochondrial ( m-aspat ) isoenzymes , human serum , and porcine s-aspat . | NA | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
84,
110
]
} | {
"id": "C0684153",
"name": "m-aspat",
"pos": [
189,
196
]
} |
final preparations of the isoenzymes were homogeneous , with specific activities of 198 and 208 ku/g for the cytoplasmic and the mitochondrial enzymes , respectively . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
26,
36
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
143,
150
]
} |
the antibiotic therapy of aspiration pneumonia was retrospectively reviewed in 74 institutionalized children with lung abscess ( 10 ) , necrotizing pneumonia ( 12 ) , and pneumonitis ( 52 ) . | NA | {
"id": "C0032290",
"name": "aspiration pneumonia",
"pos": [
26,
46
]
} | {
"id": "C0032285",
"name": "pneumonitis",
"pos": [
171,
182
]
} |
the antibiotic therapy of aspiration pneumonia was retrospectively reviewed in 74 institutionalized children with lung abscess ( 10 ) , necrotizing pneumonia ( 12 ) , and pneumonitis ( 52 ) . | NA | {
"id": "C0264515",
"name": "necrotizing pneumonia",
"pos": [
136,
157
]
} | {
"id": "C0032285",
"name": "pneumonitis",
"pos": [
171,
182
]
} |
the mean duration of therapy in the three types of pulmonary infection was : lung abscess 30.2 days , necrotizing pneumonia 26.6 days , and pneumonitis 15.1 days . | NA | {
"id": "C0264515",
"name": "necrotizing",
"pos": [
102,
113
]
} | {
"id": "C0032285",
"name": "pneumonitis",
"pos": [
140,
151
]
} |
the mean time for radiologic clearance was 35.6 days for lung abscess , 39.2 days for necrotizing pneumonia , and 13.5 days for pneumonitis . | NA | {
"id": "C0264515",
"name": "necrotizing pneumonia",
"pos": [
86,
107
]
} | {
"id": "C0032285",
"name": "pneumonitis",
"pos": [
128,
139
]
} |
there were no changes in average body weight or plasma renin for the group , but patients whose body weight increased tended to show less reduction in blood pressure ( correlation coefficient , r = 0.72 , p less than 0.05 ) and smaller increases in heart rate ( r = -.073 , p less than 0.05 ) during treatment with prazo... | NA | {
"id": "C0005911",
"name": "changes in",
"pos": [
14,
24
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
96,
107
]
} |
norepinephrine release was physiologically stimulated by change of posture and dynamic exercise in subjects while they were infused with phenylephrine , a predominant alpha 1-receptor agonist , alpha-methylnorepinephrine , a predominant alpha 2-agonist , and saline . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
194,
220
]
} |
the hemodynamic response and the increase of plasma norepinephrine induced by changes in posture and exercise were of the same order during infusions of alpha-methylnorepinephrine , phenylephrine , and saline . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
52,
66
]
} | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
153,
179
]
} |
correction of plasma concentrations for individual values of norepinephrine clearance provided an index of norepinephrine release into the circulation that was not changed by phenylephrine or alpha-methylnorepinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
61,
75
]
} | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
192,
218
]
} |
extractable radioactivity was found under hplc peaks with retention times of digoxin , digoxigenin , and its mono- and bis-digitoxosides . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
77,
84
]
} | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
87,
98
]
} |
it would appear that the significant defect in dph binding in renal disease can not be attributed to a basic functional defect in the drug-binding protein albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
147,
154
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
155,
162
]
} |
plasma albumin concentration and degree of binding do not correlate , but in normal hypoalbuminemic subjects the free fraction of dl-methadone correlates negatively with the concentration of alpha 1-acid glycoprotein ( alpha 1-agp ) , an acute-phase reactant protein . | NA | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
191,
216
]
} | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
238,
249
]
} |
dexamethasone phosphate ( 100 microgram ) altered the normal circadian rhythm of serum tsh in the adult animals , but the other two dexamethasone treatments did not affect the tsh rhythm . | NA | {
"id": "C0770565",
"name": "dexamethasone phosphate",
"pos": [
0,
23
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
132,
145
]
} |
the tissue distribution of [ 3h ] 1,25- ( oh2d3 8-40 h after iv injection of [ 3h ] 25-hydroxyvitamin d3 ( [ 3h ] 25ohd3 ) was measured in sham controls , hypophysectomized , and gh-treated hypophysectomized rats . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
84,
104
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
114,
120
]
} |
the aromatization of epitestosterone ( 17 alpha-hydroxy-4-androsten-3-one ) and testosterone by lyophilized human placental microsomes was studied . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
21,
36
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
80,
92
]
} |
at increasing substrate concentrations ( 0.1-50 microm ) , the aromatization rate of epitestosterone increased gradually and did not reach a plateau , whereas aromatization rate of testosterone plateaued at about 3 microm . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
85,
100
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
181,
193
]
} |
the presence of either testosterone or 17 beta-estradiol in concentrations 0.1-10 times the concentration of epitestosterone inhibited the aromatization of epitestosterone by about 70 % , while the aromatization of testosterone was not inhibited by either epitestosterone or 17 alpha-estradiol . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
109,
124
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
259,
271
]
} |
lyophilization of fresh microsomes or storage of the lyophilized microsomes at -20 c greatly reduced the aromatizing activity upon epitestosterone but not upon testosterone . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
131,
146
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
160,
172
]
} |
these results suggest that the aromatizing system for epitestosterone is different from that for testosterone . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
54,
69
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
97,
109
]
} |
in 6 cases pre-existing lesions of the kidneys were present ( 1 cyst , 3 hydronephrotic kidneys and 2 tumors ) . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
64,
68
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
102,
108
]
} |
the authors present their clinical experience in conservative surgery for renal cell carcinoma , which was performed in two cases of simultaneous bilateral tumours , in a case of neoplasm in solitary kidney , in two cases of cancers with damaged contralateral kidney and in two cases of association between cyst and smal... | NA | {
"id": "C0027651",
"name": "neoplasm",
"pos": [
179,
187
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
307,
311
]
} |
the quotient , calcium x oxalate/magnesium x inhibition index , was significantly higher in urine from male stone formers ( p less than 0.01 ) and the same was found for the quotient , calcium x oxalate/magnesium x citrate x inhibition index ( p less than 0.005 ) . | NA | {
"id": "C0024467",
"name": "magnesium",
"pos": [
33,
42
]
} | {
"id": "C0126774",
"name": "magnesium",
"pos": [
203,
212
]
} |
in 4 patients tlc of urine showed that interindividual variations in digitoxin elimination could possibly be attributed to variation in metabolism , resulting in the production of different metabolites . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
79,
90
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
136,
146
]
} |
to study this interaction , we selected the synapse between the splanchnic nerve and the chromaffin cells of adrenal medulla because the splanchnic nerve contains acetylcholine and neuropeptides ( multiple molecular forms of enkephalin-like peptides ) , while the membranes of chromaffin cells contain receptors for acet... | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
181,
194
]
} | {
"id": "C0205753",
"name": "opiate",
"pos": [
334,
340
]
} |
to study this interaction , we selected the synapse between the splanchnic nerve and the chromaffin cells of adrenal medulla because the splanchnic nerve contains acetylcholine and neuropeptides ( multiple molecular forms of enkephalin-like peptides ) , while the membranes of chromaffin cells contain receptors for acet... | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
225,
235
]
} | {
"id": "C0205753",
"name": "opiate",
"pos": [
334,
340
]
} |
these peroxides include hydroperoxides of arachidonic acid formed by lipoxygenase and the prostaglandin endoperoxide intermediates produced by action of prostaglandin endoperoxide synthetase . | NA | {
"id": "C0031180",
"name": "peroxides",
"pos": [
6,
15
]
} | {
"id": "C0020281",
"name": "hydroperoxides",
"pos": [
24,
38
]
} |
these peroxides include hydroperoxides of arachidonic acid formed by lipoxygenase and the prostaglandin endoperoxide intermediates produced by action of prostaglandin endoperoxide synthetase . | NA | {
"id": "C0031180",
"name": "peroxides",
"pos": [
6,
15
]
} | {
"id": "C0033541",
"name": "prostaglandin endoperoxide",
"pos": [
153,
179
]
} |
human autologous-rosette-forming t cells ( tar cells ) have many of the characteristics of post-thymic precursor cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
35,
40
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
103,
118
]
} |
in co-cultures in which we placed mononuclear cells ( mnc ) or mnc plus tar cells , or mnc depleted of tar cells or mnc depleted of tar cells plus tar cells stimulated with pwm , we determined that tar cells play a role in the generation of suppression thereby confirming that human tar cells are precursor cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
46,
51
]
} | {
"id": "C0018956",
"name": "precursor",
"pos": [
297,
306
]
} |
antibodies to the purified factor have been produced and binding studies show that omef cross-reacts with other antisera raised to an enhancing factor produced by a mixture of human allogeneic lymphocytes but shows no cross-reactivity to a murine enhancing factor . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
112,
120
]
} |
omsf is bound by antibodies raised specifically against omef and inhibits the binding of omef to this antiserum in a competitive radioimmunoassay . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
17,
27
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
102,
111
]
} |
tuberculin ( ppd ) is a particularly suitable antigenic determinant for this purpose since it behaves in many ways as a 't-cell hapten ' . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
46,
67
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
128,
134
]
} |
temporal modulation sensitivity for a 5 degree flickering field was measured in central and peripheral retina for 46 eyes with glaucoma and ocular hypertension . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
127,
135
]
} | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
140,
159
]
} |
this suggested that the increased ffa availability is an expression of adipose tissue insulin resistance , which , in contrast to glucose disappearance , remains uncompensated by the relative hyperinsulinemia . | NA | {
"id": "C0021655",
"name": "insulin",
"pos": [
86,
93
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
192,
208
]
} |
the properties of aminotransferase iv suggest that this enzyme is actually an aspartate aminotransferase ( ec 2.6.1.1 ) , corresponding to the product of the aspc gene of escherichia coli . | NA | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
18,
34
]
} | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
78,
104
]
} |
although the membrane-associated glycoproteins had molecular weights similar to those of the extracellular glycoproteins , the bulk of the membrane-associated polyuronides were of a molecular weight lower than that of the wall polyuronide . | NA | {
"id": "C0025248",
"name": "membrane",
"pos": [
13,
21
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
107,
120
]
} |
the frequency of substitution of uracil for thymine , estimated by alkaline sucrose sedimentation of phage dna treated in vitro with uracil dna glycosylase , ranged from 0.17 to 1.9 % . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
44,
51
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
133,
139
]
} |
the chromosomal beta-lactamase ( penicillinase , penp ) gene from bacillus licheniformis 749/c has been cloned in escherichia coli . | NA | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
16,
30
]
} | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
33,
46
]
} |
these parameters were quite independent of the growth rate ( the specific growth rate varied from 1.3 h-1 in broth cultures to 0.2 to 0.3 h-1 in chemostat cultures ) and of the nature of the anionic polymer in the wall ( which was teichoic acid in cultures with an excess of phosphate and teichuronic acid in phosphate-l... | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
191,
198
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
309,
318
]
} |
the groe gene product is a bacterial protein essential for the assembly of many diverse bacteriophages . | NA | {
"id": "C0033684",
"name": "gene product",
"pos": [
9,
21
]
} | {
"id": "C0004627",
"name": "bacterial protein",
"pos": [
27,
44
]
} |
the homogeneous lectin ( composed of protein to 80.7 % and of neutral carbohydrates to 14.1 % ) had a molecular weight of 78,000 ( determined by gel filtration ) and consisted of four subunits with a molecular weight of 21,000 each ( determined by gel electrophoresis in the presence of sodium dodecyl sulfate ) . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
16,
22
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
37,
44
]
} |
no gross change of membrane proteins was observed in the stalk-defective mutant cb15 pdr-803 , except a 49,000-molecular-weight ( 49k ) protein which was found reduced . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
19,
36
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
136,
143
]
} |
eighty globomycin-resistant mutants were independently isolated from escherichia coli k-12 which had a deletion mutation in chromosomal lipoprotein gene ( lpp ) , but contained a plasmid carrying the wild-type lpp gene . | NA | {
"id": "C0065058",
"name": "a",
"pos": [
24,
25
]
} | {
"id": "C0023820",
"name": "lpp",
"pos": [
210,
213
]
} |
bacillus stearothermophilus reacted to pseudomonic acid-induced inhibition of isoleucine-transfer ribonucleic acid ( rna ) acylation and to energy downshift caused by alpha-methylglucoside addition with accumulation of guanosine 3',5'-polyphosphates [ ( p ) ppgpp ] and restriction of rna synthesis . | NA | {
"id": "C0035711",
"name": "acid",
"pos": [
51,
55
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
285,
288
]
} |
these mutations resulted in su+ transfer ribonucleic acid molecules that exhibited higher transmission coefficients than their parent su+2 transfer ribonucleic acids . | NA | {
"id": "C0035711",
"name": "transfer ribonucleic acid",
"pos": [
32,
57
]
} | {
"id": "C0035668",
"name": "ribonucleic",
"pos": [
148,
159
]
} |
the purified enzyme was tightly bound to a c-type cytochrome and another peptide existing as a dehydrogenase-cytochrome complex . | NA | {
"id": "C1256752",
"name": "c-type cytochrome",
"pos": [
43,
60
]
} | {
"id": "C0010798",
"name": "cytochrome",
"pos": [
109,
119
]
} |
the effect of amino acid deprivation on the activities of d-alanine carboxypeptidase ( cpase ) and peptidoglycan transpeptidase in escherichia coli was determined . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
14,
24
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
60,
67
]
} |
the genetic determinants for k88 antigen production and the ability to utilize the trisaccharide raffinose ( raf ) are carried on a 50-megadalton plasmid . | NA | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
83,
96
]
} | {
"id": "C0034632",
"name": "raffinose",
"pos": [
97,
106
]
} |
the cloned 6.2-kilobase pair ( kbp ) eco ri fragment contains the adult beta-globin gene and a portion of the embryonic epsilon-globin gene . | NA | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
72,
83
]
} | {
"id": "C0014642",
"name": "epsilon-globin",
"pos": [
120,
134
]
} |
the guanine nucleotides gdp , gtp , and guanosine-5'- ( beta , gamma-imido ) triphosphate inhibit binding of opiates and opioid peptides to receptors solubilized from membranes of neuroblastoma x glioma ng108-15 hybrid cells . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
4,
23
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
24,
27
]
} |
the guanine nucleotides gdp , gtp , and guanosine-5'- ( beta , gamma-imido ) triphosphate inhibit binding of opiates and opioid peptides to receptors solubilized from membranes of neuroblastoma x glioma ng108-15 hybrid cells . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
4,
23
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
30,
33
]
} |
the reversal of the gpp ( nh ) p-activated state of adenylate cyclase by gtp and hormone is by the `` '' collision coupling '' '' mechanism . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
20,
32
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
73,
76
]
} |
these data are consistent with a diabetes-related unmasking of an alpha effect on cardiac phosphorylase activation and an unexplained increase in the sensitivity of phosphorylase kinase activation by protein kinase . | NA | {
"id": "C0031713",
"name": "phosphorylase",
"pos": [
90,
103
]
} | {
"id": "C0033640",
"name": "protein kinase",
"pos": [
200,
214
]
} |
the specific binding of 125i-cesalin to the enzyme was inhibited by concanavalin a , wheat germ agglutinin , macromomycin , and the antibodies prepared in rabbits against the holoenzyme and the glycoprotein subunit , but not by ouabain , simple sugars , or the antibody against the catalytic subunit . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
132,
142
]
} | {
"id": "C0162594",
"name": "antibody",
"pos": [
261,
269
]
} |
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