text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
even though ischemia developed during the occlusion , no decline in the adenylate ( atp + adp + amp ) or creatine ( pcr + cr ) pools occurred after the clamp was released , and the energy charge of the adenine nucleotides remained unchanged . | NA | {
"id": "C0031634",
"name": "pcr",
"pos": [
116,
119
]
} | {
"id": "C0010286",
"name": "cr",
"pos": [
122,
124
]
} |
the methaemoglobin content in the blood of the propositus was 17.8 % and isoelectric focusing analysis on a polyacrylamide gel plate showed that the haemoglobin consisted of 65.2 % oxyhaemoglobin ( alpha 2+ beta 2+ ) 2 , 29.6 % half-oxidized forms , 20.9 % ( alpha 3+ beta 2+ ) 2 and 8.7 % ( alpha 2+ beta 3+ ) 2 , and 3 % full-oxidized methaemoglobin ( alpha 3+ beta 3+ ) 2 . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
7,
18
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
337,
351
]
} |
to decide between these two possibilities , we prepared ( ca2+ + mg2+ ) -atpase from erythrocytes of normal ( aa ) , sickle cell trait ( as ) and sickle cell disease ( ss ) individuals . | NA | {
"id": "C0037054",
"name": "sickle cell trait",
"pos": [
117,
134
]
} | {
"id": "C0002895",
"name": "sickle cell disease",
"pos": [
146,
165
]
} |
haemoglobin values rose in the second trimester in european pregnancies associated with poor growth , whereas the values fell in the asian pregnancies both with well grown and poorly grown fetuses . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
31,
47
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
139,
150
]
} |
results of experiments with guinea-pig inclusion conjunctivitis as an animal model show that under laboratory conditions flies can readily transmit this chlamydial ocular infection from one animal to another . | NA | {
"id": "C0009770",
"name": "inclusion",
"pos": [
39,
48
]
} | {
"id": "C0008149",
"name": "chlamydial",
"pos": [
153,
163
]
} |
it is a small protein released by a subset of mature t cells following lectin-antigen activation , which in turn acts upon other t-cell subsets that have developed specific receptors for tcgf after lectin-antigen stimulation . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
14,
21
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
198,
204
]
} |
this inhibitor did not affect factor xi activation or the activity of preformed factor xia . | NA | {
"id": "C0015522",
"name": "factor xi",
"pos": [
30,
39
]
} | {
"id": "C0015524",
"name": "factor xia",
"pos": [
80,
90
]
} |
pwm-treated tg- cells showed no significant cfu-c suppressor activity , whereas pwm-treated total t and tg+ cells inhibited colony formation of both autologous and allogeneic marrow cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
16,
21
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
164,
174
]
} |
although we confirmed that hmw kininogen , bovine serum albumin , fibrinogen , cold insoluble globulin , and mixed phospholipids apparently increased prekallikrein activation , we found that the product of prekallikrein activation ( kallikrein ) lost substantial activity in less than 0.5 min after exposure to a variety of fresh surfaces . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
150,
163
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
233,
243
]
} |
evidence of continuing hospital admissions of patients with asian rickets and osteomalacia led to a further attempt to provide more effective preventive measures for the glasgow asian community . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
66,
73
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
78,
90
]
} |
when gastric emptying is slow the absorption of alcohol is delayed and peak blood alcohol concentrations are reduced . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
48,
55
]
} | {
"id": "C0684262",
"name": "blood",
"pos": [
76,
81
]
} |
in this retrospective study , the degree of differentiation of atypical lymphoid cells was assessed in pretreatment cutaneous biopsy specimens from 248 patients with cutaneous t-cell lymphomas ( mycosis fungoides and sezary syndrome ) and the findings were correlated with the subsequent therapeutic results . | NA | {
"id": "C0079773",
"name": "cutaneous t-cell lymphomas",
"pos": [
166,
192
]
} | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
217,
232
]
} |
unfavorable prognostic features were poor differentiation of the tumor , lack of histologic evidence of radiation-induced regression of the tumor , and more than three neck lymph node metastases in the initial neck dissection . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
65,
70
]
} | {
"id": "C0027666",
"name": "radiation-induced",
"pos": [
104,
121
]
} |
ultrastructure was correlated with the content of immunoreactive insulin ( iri ) and the percentage of proinsulin-like component ( plc ) in the serum , tumors , and culture fluid . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
65,
72
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
103,
113
]
} |
high levels of iri in the serum and a high percentage of plc in the serum and tumor , found in a patient with a virtually agranular tumor , combined with the fact of rare occurrence of emiocytosis , suggest a defective insulin storage mechanism and alternative routes of insulin release in insulinoma cells . | NA | {
"id": "C0033362",
"name": "plc",
"pos": [
57,
60
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
290,
297
]
} |
sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the immune complexes formed by reacting spent medium of cultured melanoma cells with xenoantiserum 8986 showed that the antiserum contains antibodies reacting with a m.w . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
74,
90
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
209,
219
]
} |
sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the immune complexes formed by reacting spent medium of cultured melanoma cells with xenoantiserum 8986 showed that the antiserum contains antibodies reacting with a m.w . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
159,
168
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
209,
219
]
} |
addition of cations to cytosols also promoted the rapid appearance of this second ionic form of receptor . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
12,
19
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
82,
87
]
} |
the influence of normal human lung fibroblasts ( nlf ) on the clonal growth of human prostatic carcinoma cells ( pc-3 ) in soft agar was studied . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
35,
46
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
105,
110
]
} |
effects of anchored nlf ( proliferating cell monolayer ) and nonanchored nlf ( nonproliferating cells embedded in agar ) on pc-3 growth were compared . | NA | {
"id": "C0016030",
"name": "nlf",
"pos": [
20,
23
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
96,
101
]
} |
the toxic and mutagenic effects of n-methyl-n'-nitro-n-nitrosoguanidine on ruba 7e cells were studied and are similar to those reported for diploid human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
83,
88
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
154,
165
]
} |
unlike human fibroblasts , in which the recovery of 6-thioguanine-resistant mutants is reduced by contact feeding when the inoculum size during selection is increased above 10 ( 4 ) cells per p60 dish , 5 to 10 x 10 ( 4 ) ruba 7e cells can be plated per p60 dish without reducing mutant recovery . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
230,
235
]
} |
furthermore , the binding and the biological action of proinsulin were about 2 % that of native insulin in the two cell lines studied . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
55,
65
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
96,
103
]
} |
the uptake of radioactive putrescine and spermidine by the transformed cells was faster than that of the normal controls . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
26,
36
]
} | {
"id": "C0037871",
"name": "transformed",
"pos": [
59,
70
]
} |
the amount of radioactive putrescine and polyamines taken up by the transformed cells also exceeded that observed with normal fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
80,
85
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
126,
137
]
} |
after 24 hr , 38 % of the sites remained in the bloom 's syndrome cells in comparison with 16 % in normal fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
66,
71
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
106,
117
]
} |
recovery of immunologically reactive antibodies and antigens from breast cancer immune complexes by preparative isoelectric focusing . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
37,
47
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
80,
96
]
} |
type i procollagen mrna activity measured in rna from nine of the lines by an in vitro translation assay also decreased with increasing severity of transformation . | NA | {
"id": "C0035696",
"name": "mrna",
"pos": [
19,
23
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
45,
48
]
} |
pancreatic carcinogenesis appeared to be enhanced in two groups which were fed diets containing 20 % corn oil , i.e. , high in unsaturated fat ; | NA | {
"id": "C0010029",
"name": "corn oil",
"pos": [
101,
109
]
} | {
"id": "C0012172",
"name": "unsaturated fat",
"pos": [
127,
142
]
} |
analysis of the nucleotide content of tumors reveals comparable spectrums of purine and pyrimidine nucleotide levels in the ll/o and ll/pala-c lines , whereas the ll/pala-j line has augmented nucleotide pools . | NA | {
"id": "C0034288",
"name": "pyrimidine nucleotide",
"pos": [
88,
109
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
192,
202
]
} |
to study whether this is a phenomenon related to malignant transformation , the release of surface macromolecules by human and murine melanoma cells was compared to that by normal allogeneic cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
143,
148
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
180,
196
]
} |
likewise in mice , the release of labeled surface macromolecules by b16 melanoma cells ( 36 % in 3 hr ) was no faster than that by normal syngeneic fibroblasts ( 56 % in 3 hr ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
81,
86
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
148,
159
]
} |
seven days after the final intubation of oh-bbn , animals were fed either a placebo diet or a diet supplemented with the following retinoids : for rats , 0.8 mmol 13-cis-retinoic acid , 2 mmol n- ( ethyl ) -all-trans-retinamide , or 2 mmol n- ( 2-hydroxyethyl ) -all-trans-retinamide per kg diet ; | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
131,
140
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic acid",
"pos": [
163,
183
]
} |
excision repair of uv damage in human cells was measured by the incorporation of new bases into dna after exposure to uv light and variety of other carcinogens including x-rays , furocoumarins plus 360 nm light ( 8-methoxypsoralen ( 8-mop ) , 4'-aminomethyl 4,5',8-trimethylpsoralen hydrochloride ( amt ) and angelicin ) , methyl methanesulfonate ( mms ) , dimethyl sulfate ( dms ) and n-methyl-n'-nitro-n-nitrosoguanidine ( mnng ) . | NA | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
179,
192
]
} | {
"id": "C0025684",
"name": "8-methoxypsoralen",
"pos": [
213,
230
]
} |
the availability of pure anhydro-araic 3'-acetate made possible a comparative study of the antineoplastic , antiviral and biochemical potencies of anhydro-araic 3'-acetate with the structurally related agents 2,2'-anhydro-1- ( 3'-o-acetyl-beta-d-arabinofuranosyl ) cytosine ( anhydro-arac 3'-acetate ) and 2,2'-anhydro-1- ( beta-d-arabinofuranosyl ) -5-iodocytosine ( anhydro-araic ) . | NA | {
"id": "C0010711",
"name": "arabinofuranosyl ) cytosine",
"pos": [
246,
273
]
} | {
"id": "C0010557",
"name": "anhydro-arac",
"pos": [
276,
288
]
} |
this was approached by measuring deuterium incorporation into chloroform and 2-chloro-1,1,1-trifluoroethane formed as microsomal metabolites of carbon tetrachloride and halothane , respectively , in a medium enriched in deuterium oxide . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
33,
42
]
} | {
"id": "C0011745",
"name": "deuterium oxide",
"pos": [
220,
235
]
} |
this paper describes the in vitro interaction between benzopyrene and steroids at the level of two rat liver monooxygenases : steroid-16 alpha-hydroxylase and aryl hydrocarbon hydroxylase ( ahh ) . | NA | {
"id": "C0038311",
"name": "steroids",
"pos": [
70,
78
]
} | {
"id": "C0072084",
"name": "steroid-16 alpha-hydroxylase",
"pos": [
126,
154
]
} |
( 2 ) ahh is supported by two cytochrome p-450 forms : a specific form which is inducible by methylcholanthrene and inhibited in vitro by alpha-naphthoflavone , but is insensitive to metyrapone and steroids ; | NA | {
"id": "C0003927",
"name": "ahh",
"pos": [
6,
9
]
} | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
30,
46
]
} |
after 2 h perfusion caffeine was extensively metabolized mainly to dimethyl and monomethyl xanthines , a minor pathway to 1,3,7-trimethyluric acid was also seen . | NA | {
"id": "C0006644",
"name": "caffeine",
"pos": [
20,
28
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
91,
100
]
} |
at na/polynucleotide ratio of 0.15 and nucleic acids concentration 100 microgram/ml the numbers of drug molecules bound per 10 ( 3 ) nucleotides were about 10 -- 13 for native calf thymus dna , 19 -- 28 for denatured dna and 23 -- 36 for rna . | NA | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
6,
20
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
133,
144
]
} |
at na/polynucleotide ratio of 0.15 and nucleic acids concentration 100 microgram/ml the numbers of drug molecules bound per 10 ( 3 ) nucleotides were about 10 -- 13 for native calf thymus dna , 19 -- 28 for denatured dna and 23 -- 36 for rna . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
39,
52
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
217,
220
]
} |
administration of saralasin , an angiotensin ii antagonist , not only prevented the compensation in ap , but also significantly magnified the maximal hypotensive response seen following d ( ch2 ) 5vdavp ( group 4 ) . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
18,
27
]
} | {
"id": "C0003009",
"name": "angiotensin",
"pos": [
33,
44
]
} |
from additional studies with purine-substituted ( n6-methyl-adenosine , n6-phenylisopropyl-adenosine ) and ribose-substituted ( 2'-deoxy-adenosine and arabino-furanosyl-adenine ) adenosine analogues , we conclude that adenosine may inhibit the inotropic responses to hormones as well as the adenylate cyclase activity by specifically interacting with at least two different sites associated with the adenylate cyclase . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
29,
35
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
169,
176
]
} |
when alpha receptors were blocked , isoproterenol and epinephrine had similar vasodilator activity , and when beta receptors were blocked , epinephrine and norepinephrine had marked vasoconstrictor activity . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
54,
65
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
156,
170
]
} |
when a diastolic sound or murmur is best heard apically , even if accompanied by a systolic murmur , mitral valve prolapse should be considered . | NA | {
"id": "C0018808",
"name": "murmur",
"pos": [
26,
32
]
} | {
"id": "C0232257",
"name": "systolic murmur",
"pos": [
83,
98
]
} |
we examined the effects of temperature on the activity and steady-state kinetics of aspartate aminotransferase ( ec 2.6.1.1 ) , using purified human soluble ( s-aspat ) and mitochondrial ( m-aspat ) isoenzymes , human serum , and porcine s-aspat . | NA | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
84,
110
]
} | {
"id": "C0684153",
"name": "m-aspat",
"pos": [
189,
196
]
} |
final preparations of the isoenzymes were homogeneous , with specific activities of 198 and 208 ku/g for the cytoplasmic and the mitochondrial enzymes , respectively . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
26,
36
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
143,
150
]
} |
the antibiotic therapy of aspiration pneumonia was retrospectively reviewed in 74 institutionalized children with lung abscess ( 10 ) , necrotizing pneumonia ( 12 ) , and pneumonitis ( 52 ) . | NA | {
"id": "C0032290",
"name": "aspiration pneumonia",
"pos": [
26,
46
]
} | {
"id": "C0032285",
"name": "pneumonitis",
"pos": [
171,
182
]
} |
the antibiotic therapy of aspiration pneumonia was retrospectively reviewed in 74 institutionalized children with lung abscess ( 10 ) , necrotizing pneumonia ( 12 ) , and pneumonitis ( 52 ) . | NA | {
"id": "C0264515",
"name": "necrotizing pneumonia",
"pos": [
136,
157
]
} | {
"id": "C0032285",
"name": "pneumonitis",
"pos": [
171,
182
]
} |
the mean duration of therapy in the three types of pulmonary infection was : lung abscess 30.2 days , necrotizing pneumonia 26.6 days , and pneumonitis 15.1 days . | NA | {
"id": "C0264515",
"name": "necrotizing",
"pos": [
102,
113
]
} | {
"id": "C0032285",
"name": "pneumonitis",
"pos": [
140,
151
]
} |
the mean time for radiologic clearance was 35.6 days for lung abscess , 39.2 days for necrotizing pneumonia , and 13.5 days for pneumonitis . | NA | {
"id": "C0264515",
"name": "necrotizing pneumonia",
"pos": [
86,
107
]
} | {
"id": "C0032285",
"name": "pneumonitis",
"pos": [
128,
139
]
} |
there were no changes in average body weight or plasma renin for the group , but patients whose body weight increased tended to show less reduction in blood pressure ( correlation coefficient , r = 0.72 , p less than 0.05 ) and smaller increases in heart rate ( r = -.073 , p less than 0.05 ) during treatment with prazosin . | NA | {
"id": "C0005911",
"name": "changes in",
"pos": [
14,
24
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
96,
107
]
} |
norepinephrine release was physiologically stimulated by change of posture and dynamic exercise in subjects while they were infused with phenylephrine , a predominant alpha 1-receptor agonist , alpha-methylnorepinephrine , a predominant alpha 2-agonist , and saline . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
194,
220
]
} |
the hemodynamic response and the increase of plasma norepinephrine induced by changes in posture and exercise were of the same order during infusions of alpha-methylnorepinephrine , phenylephrine , and saline . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
52,
66
]
} | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
153,
179
]
} |
correction of plasma concentrations for individual values of norepinephrine clearance provided an index of norepinephrine release into the circulation that was not changed by phenylephrine or alpha-methylnorepinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
61,
75
]
} | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
192,
218
]
} |
extractable radioactivity was found under hplc peaks with retention times of digoxin , digoxigenin , and its mono- and bis-digitoxosides . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
77,
84
]
} | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
87,
98
]
} |
it would appear that the significant defect in dph binding in renal disease can not be attributed to a basic functional defect in the drug-binding protein albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
147,
154
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
155,
162
]
} |
plasma albumin concentration and degree of binding do not correlate , but in normal hypoalbuminemic subjects the free fraction of dl-methadone correlates negatively with the concentration of alpha 1-acid glycoprotein ( alpha 1-agp ) , an acute-phase reactant protein . | NA | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
191,
216
]
} | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
238,
249
]
} |
dexamethasone phosphate ( 100 microgram ) altered the normal circadian rhythm of serum tsh in the adult animals , but the other two dexamethasone treatments did not affect the tsh rhythm . | NA | {
"id": "C0770565",
"name": "dexamethasone phosphate",
"pos": [
0,
23
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
132,
145
]
} |
the tissue distribution of [ 3h ] 1,25- ( oh2d3 8-40 h after iv injection of [ 3h ] 25-hydroxyvitamin d3 ( [ 3h ] 25ohd3 ) was measured in sham controls , hypophysectomized , and gh-treated hypophysectomized rats . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
84,
104
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
114,
120
]
} |
the aromatization of epitestosterone ( 17 alpha-hydroxy-4-androsten-3-one ) and testosterone by lyophilized human placental microsomes was studied . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
21,
36
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
80,
92
]
} |
at increasing substrate concentrations ( 0.1-50 microm ) , the aromatization rate of epitestosterone increased gradually and did not reach a plateau , whereas aromatization rate of testosterone plateaued at about 3 microm . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
85,
100
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
181,
193
]
} |
the presence of either testosterone or 17 beta-estradiol in concentrations 0.1-10 times the concentration of epitestosterone inhibited the aromatization of epitestosterone by about 70 % , while the aromatization of testosterone was not inhibited by either epitestosterone or 17 alpha-estradiol . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
109,
124
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
259,
271
]
} |
lyophilization of fresh microsomes or storage of the lyophilized microsomes at -20 c greatly reduced the aromatizing activity upon epitestosterone but not upon testosterone . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
131,
146
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
160,
172
]
} |
these results suggest that the aromatizing system for epitestosterone is different from that for testosterone . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
54,
69
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
97,
109
]
} |
in 6 cases pre-existing lesions of the kidneys were present ( 1 cyst , 3 hydronephrotic kidneys and 2 tumors ) . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
64,
68
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
102,
108
]
} |
the authors present their clinical experience in conservative surgery for renal cell carcinoma , which was performed in two cases of simultaneous bilateral tumours , in a case of neoplasm in solitary kidney , in two cases of cancers with damaged contralateral kidney and in two cases of association between cyst and small tumour . | NA | {
"id": "C0027651",
"name": "neoplasm",
"pos": [
179,
187
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
307,
311
]
} |
the quotient , calcium x oxalate/magnesium x inhibition index , was significantly higher in urine from male stone formers ( p less than 0.01 ) and the same was found for the quotient , calcium x oxalate/magnesium x citrate x inhibition index ( p less than 0.005 ) . | NA | {
"id": "C0024467",
"name": "magnesium",
"pos": [
33,
42
]
} | {
"id": "C0126774",
"name": "magnesium",
"pos": [
203,
212
]
} |
in 4 patients tlc of urine showed that interindividual variations in digitoxin elimination could possibly be attributed to variation in metabolism , resulting in the production of different metabolites . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
79,
90
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
136,
146
]
} |
to study this interaction , we selected the synapse between the splanchnic nerve and the chromaffin cells of adrenal medulla because the splanchnic nerve contains acetylcholine and neuropeptides ( multiple molecular forms of enkephalin-like peptides ) , while the membranes of chromaffin cells contain receptors for acetylcholine and opiate peptides . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
181,
194
]
} | {
"id": "C0205753",
"name": "opiate",
"pos": [
334,
340
]
} |
to study this interaction , we selected the synapse between the splanchnic nerve and the chromaffin cells of adrenal medulla because the splanchnic nerve contains acetylcholine and neuropeptides ( multiple molecular forms of enkephalin-like peptides ) , while the membranes of chromaffin cells contain receptors for acetylcholine and opiate peptides . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
225,
235
]
} | {
"id": "C0205753",
"name": "opiate",
"pos": [
334,
340
]
} |
these peroxides include hydroperoxides of arachidonic acid formed by lipoxygenase and the prostaglandin endoperoxide intermediates produced by action of prostaglandin endoperoxide synthetase . | NA | {
"id": "C0031180",
"name": "peroxides",
"pos": [
6,
15
]
} | {
"id": "C0020281",
"name": "hydroperoxides",
"pos": [
24,
38
]
} |
these peroxides include hydroperoxides of arachidonic acid formed by lipoxygenase and the prostaglandin endoperoxide intermediates produced by action of prostaglandin endoperoxide synthetase . | NA | {
"id": "C0031180",
"name": "peroxides",
"pos": [
6,
15
]
} | {
"id": "C0033541",
"name": "prostaglandin endoperoxide",
"pos": [
153,
179
]
} |
human autologous-rosette-forming t cells ( tar cells ) have many of the characteristics of post-thymic precursor cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
35,
40
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
103,
118
]
} |
in co-cultures in which we placed mononuclear cells ( mnc ) or mnc plus tar cells , or mnc depleted of tar cells or mnc depleted of tar cells plus tar cells stimulated with pwm , we determined that tar cells play a role in the generation of suppression thereby confirming that human tar cells are precursor cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
46,
51
]
} | {
"id": "C0018956",
"name": "precursor",
"pos": [
297,
306
]
} |
antibodies to the purified factor have been produced and binding studies show that omef cross-reacts with other antisera raised to an enhancing factor produced by a mixture of human allogeneic lymphocytes but shows no cross-reactivity to a murine enhancing factor . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
112,
120
]
} |
omsf is bound by antibodies raised specifically against omef and inhibits the binding of omef to this antiserum in a competitive radioimmunoassay . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
17,
27
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
102,
111
]
} |
tuberculin ( ppd ) is a particularly suitable antigenic determinant for this purpose since it behaves in many ways as a 't-cell hapten ' . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
46,
67
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
128,
134
]
} |
temporal modulation sensitivity for a 5 degree flickering field was measured in central and peripheral retina for 46 eyes with glaucoma and ocular hypertension . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
127,
135
]
} | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
140,
159
]
} |
this suggested that the increased ffa availability is an expression of adipose tissue insulin resistance , which , in contrast to glucose disappearance , remains uncompensated by the relative hyperinsulinemia . | NA | {
"id": "C0021655",
"name": "insulin",
"pos": [
86,
93
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
192,
208
]
} |
the properties of aminotransferase iv suggest that this enzyme is actually an aspartate aminotransferase ( ec 2.6.1.1 ) , corresponding to the product of the aspc gene of escherichia coli . | NA | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
18,
34
]
} | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
78,
104
]
} |
although the membrane-associated glycoproteins had molecular weights similar to those of the extracellular glycoproteins , the bulk of the membrane-associated polyuronides were of a molecular weight lower than that of the wall polyuronide . | NA | {
"id": "C0025248",
"name": "membrane",
"pos": [
13,
21
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
107,
120
]
} |
the frequency of substitution of uracil for thymine , estimated by alkaline sucrose sedimentation of phage dna treated in vitro with uracil dna glycosylase , ranged from 0.17 to 1.9 % . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
44,
51
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
133,
139
]
} |
the chromosomal beta-lactamase ( penicillinase , penp ) gene from bacillus licheniformis 749/c has been cloned in escherichia coli . | NA | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
16,
30
]
} | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
33,
46
]
} |
these parameters were quite independent of the growth rate ( the specific growth rate varied from 1.3 h-1 in broth cultures to 0.2 to 0.3 h-1 in chemostat cultures ) and of the nature of the anionic polymer in the wall ( which was teichoic acid in cultures with an excess of phosphate and teichuronic acid in phosphate-limited chemostat cultures ) . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
191,
198
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
309,
318
]
} |
the groe gene product is a bacterial protein essential for the assembly of many diverse bacteriophages . | NA | {
"id": "C0033684",
"name": "gene product",
"pos": [
9,
21
]
} | {
"id": "C0004627",
"name": "bacterial protein",
"pos": [
27,
44
]
} |
the homogeneous lectin ( composed of protein to 80.7 % and of neutral carbohydrates to 14.1 % ) had a molecular weight of 78,000 ( determined by gel filtration ) and consisted of four subunits with a molecular weight of 21,000 each ( determined by gel electrophoresis in the presence of sodium dodecyl sulfate ) . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
16,
22
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
37,
44
]
} |
no gross change of membrane proteins was observed in the stalk-defective mutant cb15 pdr-803 , except a 49,000-molecular-weight ( 49k ) protein which was found reduced . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
19,
36
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
136,
143
]
} |
eighty globomycin-resistant mutants were independently isolated from escherichia coli k-12 which had a deletion mutation in chromosomal lipoprotein gene ( lpp ) , but contained a plasmid carrying the wild-type lpp gene . | NA | {
"id": "C0065058",
"name": "a",
"pos": [
24,
25
]
} | {
"id": "C0023820",
"name": "lpp",
"pos": [
210,
213
]
} |
bacillus stearothermophilus reacted to pseudomonic acid-induced inhibition of isoleucine-transfer ribonucleic acid ( rna ) acylation and to energy downshift caused by alpha-methylglucoside addition with accumulation of guanosine 3',5'-polyphosphates [ ( p ) ppgpp ] and restriction of rna synthesis . | NA | {
"id": "C0035711",
"name": "acid",
"pos": [
51,
55
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
285,
288
]
} |
these mutations resulted in su+ transfer ribonucleic acid molecules that exhibited higher transmission coefficients than their parent su+2 transfer ribonucleic acids . | NA | {
"id": "C0035711",
"name": "transfer ribonucleic acid",
"pos": [
32,
57
]
} | {
"id": "C0035668",
"name": "ribonucleic",
"pos": [
148,
159
]
} |
the purified enzyme was tightly bound to a c-type cytochrome and another peptide existing as a dehydrogenase-cytochrome complex . | NA | {
"id": "C1256752",
"name": "c-type cytochrome",
"pos": [
43,
60
]
} | {
"id": "C0010798",
"name": "cytochrome",
"pos": [
109,
119
]
} |
the effect of amino acid deprivation on the activities of d-alanine carboxypeptidase ( cpase ) and peptidoglycan transpeptidase in escherichia coli was determined . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
14,
24
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
60,
67
]
} |
the genetic determinants for k88 antigen production and the ability to utilize the trisaccharide raffinose ( raf ) are carried on a 50-megadalton plasmid . | NA | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
83,
96
]
} | {
"id": "C0034632",
"name": "raffinose",
"pos": [
97,
106
]
} |
the cloned 6.2-kilobase pair ( kbp ) eco ri fragment contains the adult beta-globin gene and a portion of the embryonic epsilon-globin gene . | NA | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
72,
83
]
} | {
"id": "C0014642",
"name": "epsilon-globin",
"pos": [
120,
134
]
} |
the guanine nucleotides gdp , gtp , and guanosine-5'- ( beta , gamma-imido ) triphosphate inhibit binding of opiates and opioid peptides to receptors solubilized from membranes of neuroblastoma x glioma ng108-15 hybrid cells . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
4,
23
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
24,
27
]
} |
the guanine nucleotides gdp , gtp , and guanosine-5'- ( beta , gamma-imido ) triphosphate inhibit binding of opiates and opioid peptides to receptors solubilized from membranes of neuroblastoma x glioma ng108-15 hybrid cells . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
4,
23
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
30,
33
]
} |
the reversal of the gpp ( nh ) p-activated state of adenylate cyclase by gtp and hormone is by the `` '' collision coupling '' '' mechanism . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
20,
32
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
73,
76
]
} |
these data are consistent with a diabetes-related unmasking of an alpha effect on cardiac phosphorylase activation and an unexplained increase in the sensitivity of phosphorylase kinase activation by protein kinase . | NA | {
"id": "C0031713",
"name": "phosphorylase",
"pos": [
90,
103
]
} | {
"id": "C0033640",
"name": "protein kinase",
"pos": [
200,
214
]
} |
the specific binding of 125i-cesalin to the enzyme was inhibited by concanavalin a , wheat germ agglutinin , macromomycin , and the antibodies prepared in rabbits against the holoenzyme and the glycoprotein subunit , but not by ouabain , simple sugars , or the antibody against the catalytic subunit . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
132,
142
]
} | {
"id": "C0162594",
"name": "antibody",
"pos": [
261,
269
]
} |
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