text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these in vitro studies demonstrated that : 1 ) the spleen cells from tb rats ( tb-spleen cells ) showed strongly depressed mitogen responses to concanavalin-a ( con-a ) , phytohemagglutinin-p ( pha-p ) and lipopolysaccharide ( lps ) , 2 ) the mitogen response of lymph node cells from tb rats was slightly depressed , 3 ) the removal of plastic or nylon-wool adherent cells or phagocytic cells from tb-spleen cells resulted in a restoration of the mitogen response , 4 ) the con-a response of normal spleen cells could be suppressed by the addition of tb-whole spleen cells , 5 ) the suppressor cell activity was not abrogated by the in vitro treatment with x-irradiation ( 2000 rads ) , 6 ) carbonyl-iron treated tb-spleen cells showed a normal level of mitogen response , and on addback to normal spleen cells no suppressive activity was detected in them . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
337,
344
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
348,
353
]
} |
the activity of nadph-cytochrome c reductase and the content of cytochrome b5 were enhanced by o-toluidine only in the liver . m-toluidine enhanced the glutathione s-transferase activity while the p-isomer increased both the epoxide hydrolase and the glutathione s-transferase activities . p-toluidine decreased the ahh and aminopyrine demethylase activities and the cytochrome p-450 content . | NA | {
"id": "C0003927",
"name": "ahh",
"pos": [
316,
319
]
} | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
367,
383
]
} |
treatment of rats with 2-hx + chcl3 in vivo did not initiate peroxidation of hepatic fatty acids as determined by formation of conjugated dienes or depletion of unsaturated fatty acids , or as determined by production of malondialdehyde ( mda ) in vitro . | NA | {
"id": "C0015684",
"name": "fatty",
"pos": [
85,
90
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
161,
184
]
} |
the observed changes among poly-unsaturated fatty acids are similar to those appearing after peroxidation and either protein or essential fatty acid malnutrition . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
32,
55
]
} | {
"id": "C0015686",
"name": "essential fatty acid",
"pos": [
128,
148
]
} |
nitrate balance studies indicated that , because of metabolism , excretion of nitrate was lower than ingestion when oral doses were higher than 6.3 mumol/day . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
52,
62
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
65,
74
]
} |
metabolic derangements caused by aflatoxins include depression of protein and enzyme synthesis , disorder of lipid metabolism and immunological suppression . | NA | {
"id": "C0025517",
"name": "metabolic derangements",
"pos": [
0,
22
]
} | {
"id": "C0154251",
"name": "disorder of lipid",
"pos": [
97,
114
]
} |
with the migration of liposomes into the mucous layer on the luminal surface of the intestine up to the glycocalix level of microvilli these undergo degradation with the formation of monolayer liposomes from which polynucleotide is released . | NA | {
"id": "C0023828",
"name": "liposomes",
"pos": [
22,
31
]
} | {
"id": "C1721091",
"name": "monolayer liposomes",
"pos": [
183,
202
]
} |
the concentration of hemopoietic stem cells ( colony-forming cells in the spleen - cfc-s ) decreases in the bone marrow of cba mice during ageing , whereas the concentration of precursors for stromal fibroblasts ( colony-forming cells for fibroblasts-cfc-f ) increases . | NA | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
21,
43
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
229,
234
]
} |
the concentration of hemopoietic stem cells ( colony-forming cells in the spleen - cfc-s ) decreases in the bone marrow of cba mice during ageing , whereas the concentration of precursors for stromal fibroblasts ( colony-forming cells for fibroblasts-cfc-f ) increases . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
38,
43
]
} | {
"id": "C0016030",
"name": "cells",
"pos": [
229,
234
]
} |
adjusted mean birth weight , weaning weight and daily gain were 35.6 , 104.6 and 0.5 kg respectively . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
14,
26
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
37,
43
]
} |
of the three variables studied sex of calf significantly influenced only birth weight whereas season of birth , sire of calf , parity of dam and year of birth significantly influenced weaning weight and daily gain but not birth weight . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
79,
85
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
222,
234
]
} |
sex , season , sire , parity and year all together accounted for 18.35 , 43.49 and 46.09 % of the variation in birth weight , weaning weight and daily gain respectively . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
111,
123
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
134,
140
]
} |
birth weight increased by 0.29 kg/day increase in gestation length and 0.027 kg/kg increase in calving weight , whereas weaning weight increased by 1.31 kg/kg increase in birth weight . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
6,
12
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
171,
183
]
} |
by immunofluorescence , the well-developed filamentous cytoskeleton proved to be actin-rich . beta-hcg ( human chorionic gonadotropin ) and sp1 ( beta 1-specific pregnancy glycoprotein ) were detected in only a few tumor cells , whereas most of them stained for hpl ( human placental lactogen ) . | NA | {
"id": "C0106132",
"name": "beta-hcg",
"pos": [
94,
102
]
} | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
105,
133
]
} |
the effector cell responsible for the enhanced cytotoxicity was characterized by fractionation by adherence to nylon-wool and serum-coated plastic surfaces , density , and reactivity with certain monoclonal antibodies . | NA | {
"id": "C0028736",
"name": "nylon",
"pos": [
111,
116
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
139,
146
]
} |
the studies indicated that the ceroid granules contained an insoluble lipid as well as a component that was stainable with luxol fast blue and mallory 's phloxine stain for hyaline . | NA | {
"id": "C0007831",
"name": "ceroid",
"pos": [
31,
37
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
70,
75
]
} |
hyaline granules were devoid of lipid component and were distinctly different from either ceroid or lipofuscin . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
32,
37
]
} | {
"id": "C0007831",
"name": "ceroid",
"pos": [
90,
96
]
} |
hyaline granules were devoid of lipid component and were distinctly different from either ceroid or lipofuscin . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
32,
37
]
} | {
"id": "C0023789",
"name": "lipofuscin",
"pos": [
100,
110
]
} |
the concentrations of serum proteins ( beta 1 , beta 2 , gamma , alpha 1 , alpha 2 globulins and albumin ) and absolute numbers of eosinophils , neutrophils and lymphocytes were examined in 64 naturally infected horses and ponies in which the number of larvae of strongylus vulgaris in the cranial mesenteric artery and the severity of the lesion of verminous arteritis could be determined . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
28,
36
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
97,
104
]
} |
following an intravenous administration into rats of a shock-inducing dose of endotoxin ( 2 mg ) the lipopolysaccharide ( lps ) was demonstrated immunohistochemically ( light and electron microscopy ) and determined quantitatively ( radio-labelled lps ) in the lung tissue and in isolated alveolar macrophages . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
78,
87
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
248,
251
]
} |
the maximum extent of the immunoperoxidase reaction for endotoxin ( 100 % cells involved ) was observed on day 3 , the vast majority ( 98 % ) of the alveolar macrophages being lps-positive still on day 14 . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
56,
65
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
176,
179
]
} |
by their high capacity for storing endotoxin and their numerical superiority the mononuclear phagocytes are the leading lps-positive cells in the lung , although granulocytes , endothelial cells , and alveolar epithelial cells were sometimes also involved . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
35,
44
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
120,
123
]
} |
the different functions of the m rna are discussed in relation to those of the s rna of ssh virus . | NA | {
"id": "C0887909",
"name": "functions",
"pos": [
14,
23
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
81,
84
]
} |
dna preparations isolated from nadl-2 virus-infected cells contained two viral rf dna species : a 5000-bp infectious molecule very similar if not identical to the nadl-8 virus rf dna , and a noninfectious 4700-bp dna molecule . | NA | {
"id": "C0012939",
"name": "viral",
"pos": [
73,
78
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
213,
216
]
} |
these results indicate that two mutants in complementation group 1-1 produce a thermolabile dna-binding protein and that this protein is required for viral dna synthesis . | NA | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
92,
111
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
126,
133
]
} |
when infected cell nuclei were isolated , and the nuclear and cytoplasmic nucleic acid separately analyzed , the nuclear fraction contained the 2.0-kb dna species . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
74,
86
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
151,
154
]
} |
southern blot analysis of the nucleic acid isolated from the particles revealed the presence of hbv dna forms migrating in positions expected for 3.6- and 3.2-kb linear double-stranded molecules as well as a heterogeneous population of hbv molecules . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
30,
42
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
100,
103
]
} |
digestion of the viral nucleic acid with pancreatic ribonuclease increased the electrophoretic mobility of a portion of the heterogeneous hbv molecules and resulted in the appearance of a distinct 1.9-kb dna band suggesting the same viral dna was complexed with rna . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
23,
35
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
239,
242
]
} |
digestion of the viral nucleic acid with pancreatic ribonuclease increased the electrophoretic mobility of a portion of the heterogeneous hbv molecules and resulted in the appearance of a distinct 1.9-kb dna band suggesting the same viral dna was complexed with rna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
204,
207
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
233,
242
]
} |
thus , supercoiled hbv dna exists free in the nucleus of infected liver cells and cytoplasmic particles contain relaxed circular and linear hbv dna as well as a heterogeneous population of hbv dna and dna-rna hybrid molecules , and a dna polymerase reaction in the particles results in incorporation of dntp into dna strands of these molecules . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
232,
237
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
313,
316
]
} |
patients with esophageal and gastric cancer show a decreased diurnal excretion of dopa matched by a considerable drop in the urine levels of catecholamines and their main metabolites as compared with healthy subjects . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
82,
86
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
141,
155
]
} |
it was found that lp ( a ) is not a metabolic product of other apoprotein b containing lipoproteins , but appears to be synthesized as a separate lipoprotein . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
87,
99
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
142,
143
]
} |
on 197 patients who were admitted to a sanatorium for the purpose of a heart and circulation cure the influence of a daily swimming training , 20-30 minutes 6 times a week with intensities of about 50-60 % vo2 max , on the lipid and lipoprotein spectre , respectively was investigated . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
223,
228
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
233,
244
]
} |
the separation of the lipoproteins by disc electrophoresis and the establishment of their percental distribution resulted in a decrease of the beta-lipoproteins and an increase of the alpha-lipoproteins for the two groups ( i and ii ) . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
22,
34
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
226,
227
]
} |
apart from the still today little known pulmonal and cardiac late manifestations , the surviving persons now suffer from multiple skin tumors , such as basal cell carcinomas , bowen 's disease , bowen 's carcinoma and carcinoma spinocellulare even in unexposed parts of the skin . | NA | {
"id": "C0007117",
"name": "basal cell carcinomas",
"pos": [
152,
173
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
218,
227
]
} |
in spite of early reperfusion the patient developed an extensive myocardial infarction and died three days later from cardiogenic shock . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
65,
86
]
} | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
118,
135
]
} |
central hemodynamic values ( swan-ganz catheter ) as well as free plasma catecholamines noradrenaline and adrenaline were simultaneously determined at rest and during incremental exercise . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
88,
101
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
106,
116
]
} |
the other two produced antibodies in good titer that reacted with the antigen peptide , but were unable to recognize antigenic determinants when tested on membrane glycoproteins solubilized from human lymphoblastoid cells . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
70,
77
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
117,
139
]
} |
the fingertips of 50 hands from 35 corpses were qualitatively examined at early postmortem ( 1-4 h after death ) . | NA | {
"id": "C0006629",
"name": "corpses",
"pos": [
35,
42
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
105,
110
]
} |
the immunization of rats with a formaldehyde-inactivated vaccine of the homologous infection strain does not lead to an improved tendency for an existing infection of the urinary tract to heal in the primarily infected kidney , but it can prevent it spreading to the other one . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
83,
92
]
} | {
"id": "C0042029",
"name": "infection of",
"pos": [
154,
166
]
} |
131 pituitary adenomas ( 50 growth hormone-secreting adenomas , 19 prolactinomas , 7 adenomas associated with cushing 's disease and 55 endocrine-inactive adenomas ) have been investigated morphometrically and densitometrically by use of a system for automated microscope picture analysis ( amba ) . | NA | {
"id": "C0033375",
"name": "prolactinomas",
"pos": [
67,
80
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
155,
163
]
} |
partly clear differences by multidimensional analysis appeared between adenomas associated with cushing 's disease , somatotropic adenomas and prolactinomas . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
71,
79
]
} | {
"id": "C0033375",
"name": "prolactinomas",
"pos": [
143,
156
]
} |
possible targets of hydrolytic attack by candida proteinases in the host are immunoglobulins , the proteinase scavenger alpha-2-macroglobulin , zymogens of regulatory serine proteinases such as coagulation factor x , and angiotensinogen . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
49,
60
]
} | {
"id": "C0030946",
"name": "proteinase",
"pos": [
174,
184
]
} |
possible targets of hydrolytic attack by candida proteinases in the host are immunoglobulins , the proteinase scavenger alpha-2-macroglobulin , zymogens of regulatory serine proteinases such as coagulation factor x , and angiotensinogen . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
49,
60
]
} | {
"id": "C2717971",
"name": "serine proteinases",
"pos": [
167,
185
]
} |
analyses of the cell wall amino acid composition using gas chromatography showed that the strains contained 2.5 to 5 moles of alanine and 1 mole each of glutamic acid and lysine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
26,
36
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
126,
133
]
} |
[ nutritive value of dietary ribonucleic acid and its nucleosides in growing rats on a diet deficient in nonessential amino acid nitrogen . 3. effect of the purine nucleosides adenosine and guanosine on body composition and weight gain and nitrogen metabolism ] . | NA | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
54,
65
]
} | {
"id": "C0034136",
"name": "purine",
"pos": [
157,
163
]
} |
[ nutritive value of dietary ribonucleic acid and its nucleosides in growing rats on a diet deficient in nonessential amino acid nitrogen . 3. effect of the purine nucleosides adenosine and guanosine on body composition and weight gain and nitrogen metabolism ] . | NA | {
"id": "C0034136",
"name": "purine",
"pos": [
157,
163
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
176,
185
]
} |
[ nutritive value of dietary ribonucleic acid and its nucleosides in growing rats on a diet deficient in nonessential amino acid nitrogen . 3. effect of the purine nucleosides adenosine and guanosine on body composition and weight gain and nitrogen metabolism ] . | NA | {
"id": "C0034136",
"name": "purine",
"pos": [
157,
163
]
} | {
"id": "C0018330",
"name": "guanosine",
"pos": [
190,
199
]
} |
turbulent flow was also detected during systole in patients with septal defects ( atrial septal defect in four patients and ventricular septal defect in one patient ) in the right ventricular outflow tract and in three atrial septal defect patients also in the inflow tract , presumably because of increased volume of flow . | NA | {
"id": "C0018816",
"name": "septal defects",
"pos": [
65,
79
]
} | {
"id": "C0018818",
"name": "ventricular septal defect",
"pos": [
124,
149
]
} |
turbulent flow was also detected during systole in patients with septal defects ( atrial septal defect in four patients and ventricular septal defect in one patient ) in the right ventricular outflow tract and in three atrial septal defect patients also in the inflow tract , presumably because of increased volume of flow . | NA | {
"id": "C0018816",
"name": "septal defects",
"pos": [
65,
79
]
} | {
"id": "C0018817",
"name": "atrial septal defect",
"pos": [
219,
239
]
} |
the mean hormone concentrations in pf were significantly higher when the stigma was present ( 17-beta-estradiol , p less than 0,05 ; progesterone , p less than 0,01 ; 17-oh-progesterone , p less than 0,05 ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
133,
145
]
} | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
167,
185
]
} |
in this study normal patients with a tubal sterility were treated with clomiphene citrate and clomiphene plus h.m.g . | NA | {
"id": "C0546859",
"name": "clomiphene citrate",
"pos": [
71,
89
]
} | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
94,
104
]
} |
determination of liver glycogen content of unbled shr and wky indicated that the deficient hyperglycaemic response in shr was not due to inadequate glycogen stores but rather to poor liver perfusion resulting in liver hypoxia . | NA | {
"id": "C0023902",
"name": "liver",
"pos": [
17,
22
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
148,
156
]
} |
there were no significant differences between weight gainers and weight-stable patients with regard to age , sex , pretreatment overweight , duration of treatment , dosage or serum levels of valproate . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
46,
52
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
128,
138
]
} |
isoelectric focusing of csf-enriched proteins obtained by absorption chromatography showed alterations in nine out of 17 exposed individuals : the most prominent change was a relative increase of the protein band with ip 4.7 . | NA | {
"id": "C0007810",
"name": "csf",
"pos": [
24,
27
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
200,
207
]
} |
2500-3000 eyes with ocular hypertension , with or without established glaucoma in the fellow eye , were followed with automatic perimetry for several years . | NA | {
"id": "C0028840",
"name": "eyes",
"pos": [
10,
14
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
70,
78
]
} |
it is stressed that sjogren syndrome is often associated with other diseases of the connective tissue such as rheumatoid arthritis and lupus erythematodes disseminatus . | NA | {
"id": "C1527336",
"name": "sjogren syndrome",
"pos": [
20,
36
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
110,
130
]
} |
plasma adrenaline and noradrenaline concentrations at birth were the same in infants of diabetic mothers and controls after both vaginal and abdominal delivery . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
7,
17
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
22,
35
]
} |
a japanese female infant with typical features of leprechaunism exhibited glucose intolerance despite marked hyperinsulinemia , indicating insulin resistance . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
109,
125
]
} | {
"id": "C0021655",
"name": "insulin",
"pos": [
139,
146
]
} |
it was considered that the tumor was benign and that the regional lymph node involvement probably represents a multicentric hamartomatous or choristomatous growth . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
27,
32
]
} | {
"id": "C0018552",
"name": "hamartomatous",
"pos": [
124,
137
]
} |
studies were made on the effects of butylated hydroxyanisole ( bha ) , butylated hydroxytoluene ( bht ) , sodium l-ascorbate ( sa ) , ethoxyquin ( eq ) and acetaminophen ( aaf ) on the induction of neoplastic lesions in the liver , kidney or urinary bladder of rats initiated by n-ethyl-n-hydroxyethylnitrosamine ( ehen ) , diethylnitrosamine ( den ) or n-butyl-n- ( 4-hydroxybutyl ) nitrosamine ( bbn ) . | NA | {
"id": "C0012200",
"name": "diethylnitrosamine",
"pos": [
324,
342
]
} | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
384,
395
]
} |
the rate of conversion in vitro , of prekallikrein to kallikrein has been measured in 74 reactors to contrast medium and 70 controls . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
37,
50
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
54,
64
]
} |
this retrospective investigation suggests that prekallikrein/kallikrein conversion rate may form the basis of a test for differentiating between reactors and non-reactors . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
47,
60
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
61,
71
]
} |
this model fits the generally accepted opinion that the effect of oestrogen on bone loss in postmenopausal osteoporosis is limited , declines with age , and is dose-related . | NA | {
"id": "C0029458",
"name": "bone loss",
"pos": [
79,
88
]
} | {
"id": "C0029456",
"name": "osteoporosis",
"pos": [
107,
119
]
} |
serious dysrhythmias ( ventricular tachycardia , ventricular fibrillation , and asystole ) were significantly more frequent in hypokalemic patients . | NA | {
"id": "C0003811",
"name": "dysrhythmias",
"pos": [
8,
20
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
49,
73
]
} |
mean body weight decreased by 10 kg during fasting , blood glucose was normalized , urinary glucose disappeared and the k-value at i.v . glucose tolerance test increased . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
53,
66
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
137,
144
]
} |
the median values for plasma triglycerides ( tg ) , cholesterol , low density lipoprotein ( ldl ) cholesterol , apolipoprotein b and lipolytic activities ( lipoprotein lipase and hepatic lipase ) were insignificantly higher in capd plasma than in hd plasma . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
52,
63
]
} | {
"id": "C0023824",
"name": "low density",
"pos": [
66,
77
]
} |
the vacterl-association , i.e . three or more closely defined vacterl-type abnormalities without other major abnormalities may , however , present a distinct congenital abnormality entity because ( i ) the combination of vacterl-type abnormalities is much higher than the expected one , ( ii ) the majority of cases could not be identified as other multiple congenital abnormality entities and ( iii ) it has some epidemiological characteristics ( e.g . male preponderance ) . | NA | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
75,
88
]
} | {
"id": "C0000772",
"name": "multiple congenital",
"pos": [
349,
368
]
} |
incubation with oxidized ldl resulted in a 6 fold increase in cholesterol ester , while incubation with native ldl did not result in cholesterol accumulation . | NA | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
62,
79
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
133,
144
]
} |
as long as these adaptive changes in synthesis are adequate to meet the changing needs for cholesterol in the animal , the rates of receptor-mediated ldl degradation by the liver and intestine remain essentially unchanged as does the plasma ldl-cholesterol concentration . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
91,
102
]
} | {
"id": "C0023824",
"name": "ldl-cholesterol",
"pos": [
241,
256
]
} |
[ a comparative study of the effects of naf , fluor-protector and amine fluoride on the enamel of permanent teeth in children ] . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
40,
43
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
72,
80
]
} |
after the introduction of self-catheterization , urinary tract infection was evaluated on the basis of the incidence of pyuria defined as more than 5 white blood cells per high magnification field . | NA | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
49,
72
]
} | {
"id": "C0034359",
"name": "pyuria",
"pos": [
120,
126
]
} |
the clinical efficacy of ( d-leu6 ) -des gly-nh2 ( 10 ) -lh x rh ethylamide ( leuprolide ) against prostatic cancer was evaluated at the end of twelve weeks of administration of a daily dose of 20 mg subcutaneous injection to 22 patients with prostatic cancer . | NA | {
"id": "C0023610",
"name": "lh",
"pos": [
57,
59
]
} | {
"id": "C0085272",
"name": "leuprolide",
"pos": [
78,
88
]
} |
radiologically , these syndromes had diffuse abnormalities of gastrointestinal motor function manifested by small and large intestinal dilatation , esophageal hypomotility ( progressive systemic sclerosis and visceral myopathy ) , or disordered hypercontractility ( visceral neuropathy ) . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
23,
32
]
} | {
"id": "C0012634",
"name": "disordered",
"pos": [
234,
244
]
} |
among 189 patients treated for massive or repeated hemoptysis by transcatheter techniques between 1973 and 1983 , a prospective study was attempted between 1979 and 1983 ( 72 patients ) to search for bleeding of pulmonary arterial origin . | NA | {
"id": "C0019079",
"name": "hemoptysis",
"pos": [
51,
61
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
200,
208
]
} |
these observations suggest that hla-d/dr antigens , the human counterpart of murine ia antigens coded for by the i-e subregion of the h-2 complex , expressed on non-t cells or activated t cells participate in the stimulation of amlc . | NA | {
"id": "C0019764",
"name": "hla",
"pos": [
32,
35
]
} | {
"id": "C0019754",
"name": "human",
"pos": [
56,
61
]
} |
all of the beta blockers act by antagonizing the actions of the endogenous adrenergic agonists epinephrine and norepinephrine at the beta-adrenergic receptors . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
95,
106
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
111,
125
]
} |
to evaluate myocardial catecholamine balance in heart failure , systemic hemodynamics , coronary sinus blood flow , and arterial and coronary sinus venous norepinephrine ( ne ) and epinephrine ( e ) concentrations were determined in 30 patients with chronic left ventricular failure ( chf ) , and in 25 patients with angina pectoris ( ap ) but without heart failure . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
155,
169
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
181,
192
]
} |
the pathologic anatomic features and associated cardiac anomalies of 63 cases of interruption of the aortic arch ( iaa ) type a ( 54 reported and 9 observed ) and 145 cases of type b ( 124 reported and 21 observed ) were analyzed and compared with those seen in 57 autopsy cases of infant coarctation of the aorta ( ca ) . | NA | {
"id": "C0018798",
"name": "cardiac anomalies",
"pos": [
48,
65
]
} | {
"id": "C0003492",
"name": "of",
"pos": [
301,
303
]
} |
after incubation for 24 h with lipoprotein-depleted serum ( which induces ldl receptor synthesis ) , and then incubation for 24 h with an increasing amount of ldl ( from 10 to 250 micrograms of protein per ml ) , the tocopherol contents of normal fibroblasts increased in a saturable fashion from 19 to 103 ng of tocopherol per mg cell protein . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
247,
258
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
331,
335
]
} |
the amount of pg metabolites , pg-e , sodium , and creatinine in 24-h urine increased with augmented linoleic acid intake . | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
14,
16
]
} | {
"id": "C0033559",
"name": "pg-e",
"pos": [
31,
35
]
} |
eight lactating women were given supplements of a fish oil concentrate rich in omega-3 fatty acids , including dha ( 11 % of fatty acids ) . | NA | {
"id": "C0016157",
"name": "fish",
"pos": [
50,
54
]
} | {
"id": "C0015689",
"name": "omega-3 fatty acids",
"pos": [
79,
98
]
} |
since dietary intakes of cholesterol are not significantly different among the two nonvegetarian groups , the differences in excretion values are attributable to differences in colonic metabolism . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
125,
134
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
185,
195
]
} |
three-day composite diets , and stools were analyzed for neutral detergent fiber ( ndf ) , hemi-cellulose , lignin , cellulose , cutin + silica , and pectin . | NA | {
"id": "C0023705",
"name": "lignin",
"pos": [
108,
114
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
117,
126
]
} |
general population nonvegetarians , 52.5 +/- 4.9 ) , lignin , cellulose , and pectin being the major contributors to this difference . | NA | {
"id": "C0023705",
"name": "lignin",
"pos": [
53,
59
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
62,
71
]
} |
the system is set in motion by clinically significant pain -- such as that resulting from bony fractures or postoperative pain . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
54,
58
]
} | {
"id": "C0030201",
"name": "postoperative pain",
"pos": [
108,
126
]
} |
there is substantial evidence that combining an optimal dose of acetaminophen or aspirin with an oral opioid such as codeine , hydrocodone , or oxycodone produces an additive analgesic effect greater than that obtained by doubling the dose of either constituent administered alone . | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
117,
124
]
} | {
"id": "C0020264",
"name": "hydrocodone",
"pos": [
127,
138
]
} |
there is substantial evidence that combining an optimal dose of acetaminophen or aspirin with an oral opioid such as codeine , hydrocodone , or oxycodone produces an additive analgesic effect greater than that obtained by doubling the dose of either constituent administered alone . | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
117,
124
]
} | {
"id": "C0030049",
"name": "oxycodone",
"pos": [
144,
153
]
} |
utilizing monoclonal antibody l243 , the expression of this glycoprotein on circulating t lymphocytes was studied in five patients with recent-onset idiopathic addison 's disease , one patient with recent-onset adrenal hemorrhage , and nine patients with long-standing adrenal insufficiency ( five with idiopathic addison 's disease and four after bilateral adrenalectomy for cushing 's disease ) . | NA | {
"id": "C0001623",
"name": "adrenal insufficiency",
"pos": [
269,
290
]
} | {
"id": "C0001403",
"name": "addison 's disease",
"pos": [
314,
332
]
} |
an appreciation of the potential for rhabdomyolysis in hyperthyroidism should facilitate prompt initiation of aggressive therapy for myoglobinuria and thereby limit the severity of acute renal failure in these already very sick patients . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
37,
51
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
133,
146
]
} |
radioligand binding studies on the density and characteristics of alpha adrenoceptors have not revealed consistent differences between normotensive and hypertensive subjects , with the exception of pheochromocytoma , in which a consistent down regulation of alpha 2 adrenoceptors in thrombocytes has been demonstrated . | NA | {
"id": "C0034784",
"name": "alpha adrenoceptors",
"pos": [
66,
85
]
} | {
"id": "C0001639",
"name": "alpha 2 adrenoceptors",
"pos": [
258,
279
]
} |
with controls for gestational age and fetal sex , the following maternal variables were positively correlated with birth weight : prepregnant weight , weight gain in pregnancy , stature , bicristal and biacromial diameter , calf and upper arm circumference , and triceps and subscapular skinfold thickness . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
115,
127
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
151,
157
]
} |
diagnoses included alpha-thalassemia trait , beta-thalassemia trait , hemoglobin c trait , hemoglobin s/c disease , hemoglobin s trait , sickle cell anemia , and hemoglobin lepore . | NA | {
"id": "C0037054",
"name": "hemoglobin s trait",
"pos": [
116,
134
]
} | {
"id": "C0002895",
"name": "sickle cell anemia",
"pos": [
137,
155
]
} |
nonetheless , a number of factors , including exposure to water from the tiro-sigli river and consumption of ice , were associated with disease . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
58,
63
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
109,
112
]
} |
this silver stain , when applied to dna , is at least as sensitive as ethidium bromide , and gives a linear response for the type of dna and fragment sizes studied . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
36,
39
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
143,
144
]
} |
its application to porphyrin analysis has been demonstrated using high-performance liquid chromatographic resolution of the uro- to protoporphyrins in normal and porphyric urine . | NA | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
19,
28
]
} | {
"id": "C0033733",
"name": "protoporphyrins",
"pos": [
132,
147
]
} |
a relatively large body of literature data involving a variety of membrane proteins , membrane types , and irradiation conditions ( electron accelerators or 60co sources , and proteins irradiated in lyophilized form or frozen solution ) was examined , and it was concluded that target sizes of membrane proteins , irradiated in the presence of triton x-100 , should be diminished by a factor of about 24 % to obtain the molecular weight value . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
66,
83
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
303,
311
]
} |
the procedure has been applied to nitrogenase , continuously monitoring creatine produced from creatine phosphate by creatine kinase which is used to supply a constant level of atp for nitrogenase . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
72,
80
]
} | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
95,
113
]
} |
in vitro procollagen production rates can be determined by culturing cells in the presence of [ 3h ] proline and measuring the subsequent formation of [ 3h ] hydroxyproline . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
101,
108
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
158,
172
]
} |
confluent fibroblasts ( imr-90 ) were cultured in fresh medium containing [ 3h ] proline , and [ 3h ] hydroxyproline production and prolyl hydroxylation were measured . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
81,
88
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
102,
116
]
} |
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