text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
also , the sera of mrl/l mice contain autoantibodies to nuclear antigens as well as igm and igg rheumatoid factors . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
38,
52
]
} | {
"id": "C0035448",
"name": "rheumatoid factors",
"pos": [
96,
114
]
} |
following controlled alcohol doses to eight healthy volunteers without cimetidine and after three days cimetidine in the two dosage regimens , blood alcohol concentrations were determined and the degree of intoxication was recorded subjectively on a 100 mm scale . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
21,
28
]
} | {
"id": "C0684262",
"name": "blood alcohol concentrations",
"pos": [
143,
171
]
} |
he developed a grand mal seizure at the age of 39 and thereafter , his clinical course was characterized by pyramidal signs , dysarthria and the symptoms of gerstmann 's syndrome , visuo-spatial agnosia , apraxia for dressing and constructive apraxia . | NA | {
"id": "C0017494",
"name": "gerstmann 's syndrome",
"pos": [
157,
178
]
} | {
"id": "C0001816",
"name": "agnosia",
"pos": [
195,
202
]
} |
the potencies of caffeine , theophylline , lysine-theophylline and 3-isobutyl-1-methylxanthine ( ibmx ) in stimulating sperm motility have been compared , and we have found ibmx to be significantly more potent than the other three compounds , which did not exhibit significant differences in potency from each other . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
28,
40
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methylxanthine",
"pos": [
67,
94
]
} |
blood pressure , body weight , na+ and k+ balance , and plasma concentrations of na+ , k+ , active and total renin , angiotensin ii , aldosterone , 11-deoxycorticosterone ( doc ) , 18-hydroxydeoxycorticosterone ( 18-oh doc ) , corticosterone ( b ) , 18-hydroxycorticosterone ( 18-oh b ) and cortisol were measured before and on each day of treatment . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
156,
170
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
250,
274
]
} |
when pregnant patients received the equivalent of either 6 or 12 mg betamethasone in a formulation containing 3.1 mg/ml betamethasone acetate suspended in a solution of 4 mg/ml betamethasone phosphate ( celestone chronodose ) , much of the phosphate ester was absorbed intact but betamethasone acetate was not detected in plasma . | NA | {
"id": "C0005308",
"name": "betamethasone",
"pos": [
68,
81
]
} | {
"id": "C0005310",
"name": "betamethasone",
"pos": [
280,
293
]
} |
patients treated with carbamazepine ( cbz ) , phenytoin ( dph ) , primidone ( pmd ) and phenobarbitone ( pb ) , either alone or in combination , showed higher values of antipyrine clearance and excreted larger amounts of d-ga as compared to controls . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
66,
75
]
} | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
88,
102
]
} |
significant positive correlations were found between the dosage of cbz , dph , pmd and pb and both indices of enzyme induction . | NA | {
"id": "C0033148",
"name": "pmd",
"pos": [
79,
82
]
} | {
"id": "C0031412",
"name": "pb",
"pos": [
87,
89
]
} |
the relative potency at average dose levels for antipyrine clearance was pb ( 1 ) , dph ( 0.92 ) , cbz ( 0.84 ) , pmd ( 0.82 ) and for log d-ga excretion was pb ( 1 ) , cbz ( 0.96 ) , pmd ( 0.95 ) , dph ( 0.90 ) . | NA | {
"id": "C0031412",
"name": "pb",
"pos": [
73,
75
]
} | {
"id": "C0033148",
"name": "pmd",
"pos": [
184,
187
]
} |
the effects of paracetamol dose ( 5 and 20 mg/kg ) and route of administration ( intravenous and oral ) on the urinary excretion of paracetamol and its glucuronide , sulphate , cysteine and mercapturic acid conjugates were studied in five healthy subjects . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
177,
185
]
} | {
"id": "C0001047",
"name": "mercapturic acid",
"pos": [
190,
206
]
} |
blood ethanol concentrations were not influenced by the co-administration of either antidepressant . tmax for trazodone was prolonged by ethanol but the other pharmacokinetic parameters for trazodone and amitriptyline were not influenced by ethanol . | NA | {
"id": "C0684262",
"name": "blood ethanol",
"pos": [
0,
13
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
241,
248
]
} |
pindolol kinetics and bioavailability were studied after a single dose ( oral 5 mg ; intravenous 3 mg ) in nine patients with malabsorption ( two with villous atrophies , seven with short bowel syndromes ) and in six healthy volunteers . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
126,
139
]
} | {
"id": "C0036992",
"name": "short bowel syndromes",
"pos": [
182,
203
]
} |
treatment with difluoromethylornithine decreased the concentrations of putrescine and spermidine in both normal and uninvolved psoriatic keratinocytes , but had no effect on either dna or protein synthesis . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
71,
81
]
} | {
"id": "C0037871",
"name": "normal",
"pos": [
105,
111
]
} |
porphyrin excretion , particularly uroporphyrin in the urine and stools , was still significantly increased in seventeen patients . | NA | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
0,
9
]
} | {
"id": "C0042093",
"name": "uroporphyrin",
"pos": [
35,
47
]
} |
simultaneous measurements of the deuterium magnetic resonance spectra of popc with specifically deuterated choline head groups revealed a linear relationship between the quadrupole splitting and the amount of bound ca2+ . | NA | {
"id": "C0031716",
"name": "popc",
"pos": [
73,
77
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
107,
114
]
} |
we apply our equations to analyze esr data from delipidated sarcoplasmic reticulum membranes and from egg yolk phosphatidylcholine bilayers containing ca2+-atpase , and dph data from dipalmitoylphosphatidylcholine ( dppc ) bilayers containing ca2+-atpase , both for t greater than tc . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
111,
130
]
} | {
"id": "C0000039",
"name": "dipalmitoylphosphatidylcholine",
"pos": [
183,
213
]
} |
the oxidation of ferric cytochrome c peroxidase by hydrogen peroxide yields a product , compound es [ yonetani , t. , schleyer , h. , chance , b. , & ehrenberg , a . ( 1967 ) in hemes and hemoproteins ( chance , b. , estabrook , r. w. , & yonetani , t. , eds . ) p 293 , academic press , new york ] , containing an oxyferryl heme and a protein free radical [ dolphin , d. , forman , a. , borg , d. c. , fajer , j. , & felton , r. h. ( 1971 ) proc . natl . acad . sci . u.s.a. 68 , 614-618 ] . | NA | {
"id": "C0018974",
"name": "hemoproteins",
"pos": [
188,
200
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
336,
343
]
} |
addition of sodium fluoride to fe ( iv ) peroxidase gives a product with an optical spectrum similar to that of the fluoride complex of the ferric enzyme . | NA | {
"id": "C0037508",
"name": "sodium",
"pos": [
12,
18
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
116,
124
]
} |
the supernatant ( total soluble maps ) contained almost no tubulin , most of the nucleosidediphosphate kinase activity of the microtubule protein , good activity in promoting microtubule assembly in 0.1 m mes , and proteins with the electrophoretic mobility of map-1 , map-2 , and tau factor . | NA | {
"id": "C0026045",
"name": "maps",
"pos": [
32,
36
]
} | {
"id": "C0085401",
"name": "tau factor",
"pos": [
281,
291
]
} |
the bound component ( deae-maps ) contained proteins with the electrophoretic mobility of map-1 , map-2 , and tau factor . | NA | {
"id": "C0026045",
"name": "maps",
"pos": [
27,
31
]
} | {
"id": "C0085401",
"name": "tau",
"pos": [
110,
113
]
} |
it has been postulated that the three galactose-combining sites of the lectin are arranged in space at the vertexes of a triangle whose sides are 15 , 22 , and 25 a [ lee , y. c. , townsend , r. r. , hardy , m. r. , lonngren , j. , & bock , k. ( 1984 ) in biochemical and biophysical studies of proteins and nucleic acids ( lo , t. b. , liu , t. y. , & li , c. h. , eds . ) pp 349-360 , elsevier , new york ] . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
71,
77
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
295,
303
]
} |
these measurements were performed on three synthetic polynucleotides having different overall conformations , poly- ( da-dt ) .poly ( da-dt ) ( alternating b-dna ) , poly ( dg-dc ) .poly ( dg-dc ) at low salt ( b-dna ) , and br-poly ( dg-dc ) .br-poly ( dg-dc ) ( left-handed z-dna ) , and on four types of natural dna differing in base composition , clostridium perfringens ( 26 % gc ) , calf thymus ( 40 % gc ) , escherichia coli ( 50 % gc ) , and micrococcus lysodeikticus ( 72 % gc ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
158,
161
]
} | {
"id": "C0919262",
"name": "b-dna",
"pos": [
211,
216
]
} |
these measurements were performed on three synthetic polynucleotides having different overall conformations , poly- ( da-dt ) .poly ( da-dt ) ( alternating b-dna ) , poly ( dg-dc ) .poly ( dg-dc ) at low salt ( b-dna ) , and br-poly ( dg-dc ) .br-poly ( dg-dc ) ( left-handed z-dna ) , and on four types of natural dna differing in base composition , clostridium perfringens ( 26 % gc ) , calf thymus ( 40 % gc ) , escherichia coli ( 50 % gc ) , and micrococcus lysodeikticus ( 72 % gc ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
158,
161
]
} | {
"id": "C0043442",
"name": "left-handed",
"pos": [
264,
275
]
} |
in experiments with rat-liver mitochondria incubated under state-4 conditions , it was found that the extramitochondrial atp/adp ratio , as calculated from the values measured in neutralised perchloric acid extracts , was lower than that estimated from the concentrations of creatine and creatine phosphate , using the metabolite indicator method . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
275,
283
]
} | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
288,
306
]
} |
in the bypass promoted by tmpd its oxidized form ( wurster 's blue ) acts as an electron acceptor from some reduced component prior to the antimycin block , which by exclusion of other possibilities is ubisemiquinone . | NA | {
"id": "C0031468",
"name": "tmpd",
"pos": [
26,
30
]
} | {
"id": "C0039690",
"name": "wurster 's blue",
"pos": [
51,
66
]
} |
when chromatophores were fused with small , unilamellar liposomes , the intramembrane particle density decreased as input liposome phospholipid increased , whereas the particle size remained constant and particle distribution became random . | NA | {
"id": "C1721091",
"name": "unilamellar liposomes",
"pos": [
44,
65
]
} | {
"id": "C0023828",
"name": "liposome",
"pos": [
122,
130
]
} |
the effective dielectric constants of the sodium decyl sulfate , dodecyl sulfate and tetradecyl sulfate micelles were 29 , 31 and 33 , respectively . | NA | {
"id": "C0074769",
"name": "sodium",
"pos": [
42,
48
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
96,
103
]
} |
two protease-sensitive enzymes of the cell interior ( lactate dehydrogenase and nadph-cytochrome c reductase ) are not affected by protease treatment of intact cells . | NA | {
"id": "C0030940",
"name": "protease",
"pos": [
4,
12
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
131,
139
]
} |
three bovine intermediate filament proteins , glial fibrillary acidic protein , desmin and the 70 kda component of the neurofilament are compared by cleavage at cysteine and tryptophan . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
13,
43
]
} | {
"id": "C0017626",
"name": "glial fibrillary acidic protein",
"pos": [
46,
77
]
} |
variants of creatine kinase-mm ( variant of atp : creatine n-phosphotransferase , ec 2.7.3.2 ) , present in human heart and skeletal muscle , have been purified to homogeneity using deae-sepharose column chromatography and column chromatofocusing techniques . | NA | {
"id": "C0010291",
"name": "creatine kinase-mm",
"pos": [
12,
30
]
} | {
"id": "C0010287",
"name": "creatine",
"pos": [
50,
58
]
} |
the enzyme from intestinal mucosa was sharply different from the other two isoenzymes : sds had little effect at ph 7.5 but very rapidly denatured the enzyme at ph 10.3 . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
75,
85
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
151,
157
]
} |
the site of action of the protein appears to be at the level of the guanine nucleotide regulatory ( g ) protein of the plasma membrane adenylate cyclase complex , as the factor , cooperatively with gtp , also permitted cholera toxin to adp-ribosylate ( from 32p-labeled nad ) two integral membrane proteins that migrated on sds-polyacrylamide gel electrophoresis gels with the mobilities ( mr approx . 46 000 and 48 000 ) generally observed for the guanine nucleotide regulator protein subunits . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
26,
33
]
} | {
"id": "C0599220",
"name": "protein",
"pos": [
478,
485
]
} |
the site of action of the protein appears to be at the level of the guanine nucleotide regulatory ( g ) protein of the plasma membrane adenylate cyclase complex , as the factor , cooperatively with gtp , also permitted cholera toxin to adp-ribosylate ( from 32p-labeled nad ) two integral membrane proteins that migrated on sds-polyacrylamide gel electrophoresis gels with the mobilities ( mr approx . 46 000 and 48 000 ) generally observed for the guanine nucleotide regulator protein subunits . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
198,
201
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
449,
467
]
} |
human iduronate 2-sulphate sulphatase ( ec 3.1.6.- ) from urine has been purified by affinity chromatography on concanavalin a-sepharose , ammonium sulphate fractionation and deae-cellulose chromatography . | NA | {
"id": "C0038720",
"name": "sulphate",
"pos": [
18,
26
]
} | {
"id": "C0002620",
"name": "ammonium sulphate",
"pos": [
139,
156
]
} |
the soluble , cytochrome p-450-dependent fatty acid monooxygenase of bacillus megaterium atcc 14581 is induced by phenobarbital and at least twelve other barbiturates ( kim , b.-h. and fulco , a.j . ( 1983 ) biochem . biophys . res . commun . 116 , 843-850 ) . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
114,
127
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
154,
166
]
} |
oxidation of lactaldehyde by cytosolic aldehyde dehydrogenase and inhibition of cytosolic and mitochondrial aldehyde dehydrogenase by metabolites . | NA | {
"id": "C0001985",
"name": "aldehyde dehydrogenase",
"pos": [
39,
61
]
} | {
"id": "C2827577",
"name": "mitochondrial aldehyde dehydrogenase",
"pos": [
94,
130
]
} |
the enzyme was not inhibited by inhibitors of serine proteinases , cysteine proteinases or acid proteinases , but only by the metalloproteinase inhibitor , edta . | NA | {
"id": "C2717970",
"name": "cysteine",
"pos": [
67,
75
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
96,
107
]
} |
the reaction between t-pa or u-pa and the plasminogen activator-binding component was blocked by 5 mm p-aminobenzamidine , while the complexes , once formed , could be cleaved by 1.5 m nh4oh/39 mm sds . | NA | {
"id": "C0032143",
"name": "t-pa",
"pos": [
21,
25
]
} | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
42,
63
]
} |
especially , both spermine and spermidine levels were reduced below 50 % of those in control cells after 48 h and below 30 % after 96 h . | NA | {
"id": "C0037874",
"name": "spermine",
"pos": [
18,
26
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
42,
48
]
} |
a variant of unisotopic optical dna-dna molecular hybridization method basing on the study of reassociation rate of dna renaturation fragments is described . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
116,
119
]
} |
the main topics discussed are silicone rubber , elastomers for artificial blood pumps , and the methodology of model fatigue-life testing . | NA | {
"id": "C0037110",
"name": "silicone rubber",
"pos": [
30,
45
]
} | {
"id": "C0013766",
"name": "elastomers",
"pos": [
48,
58
]
} |
when dextran aldehyde prepared by periodate oxidation of dextran was used as a binder instead of glutaraldehyde , complement activation by f ( ab ' ) 2-polymer conjugate was remarkably reduced , though antibody activity for binding the antigen remained . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
13,
21
]
} | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
97,
111
]
} |
the results are discussed within context of a theory that assigns the exchange of the major part of k in its slow exponential fraction and the na exchange in s2 to interactions of these ions with fixed anionic sites , on intracellular macromolecules , which have been shown previously to interact cooperatively in their association with k and na . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
172,
176
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
202,
209
]
} |
anionic buffer conjugate bases ( phosphate and acetate ) show a greater catalytic effect than neutral ( nitrogen ) bases , especially with cytosine compounds . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
0,
7
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
33,
42
]
} |
the results from in vitro studies showed that the penicillins including oxacillin and dicloxacillin were effective in displacing phenytoin from its binding sites . | NA | {
"id": "C0030842",
"name": "penicillins",
"pos": [
50,
61
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
90,
99
]
} |
the bioavailability and pharmacokinetics of salicylic acid ( sa ) were studied after single and multiple doses of a new slow-release formulation , based on porous membrane diffusion of sodium salicylate ( nasa ) . | NA | {
"id": "C0036079",
"name": "salicylic acid",
"pos": [
44,
58
]
} | {
"id": "C0037549",
"name": "sodium salicylate",
"pos": [
185,
202
]
} |
enalapril , the ethyl ester of a potent angiotensin converting enzyme inhibitor , enalaprilat , was administered to healthy volunteers as a capsule containing 10 mg of the maleate salt , every 24h for eight doses . | NA | {
"id": "C0014025",
"name": "enalapril",
"pos": [
0,
9
]
} | {
"id": "C0014027",
"name": "enalaprilat",
"pos": [
82,
93
]
} |
in the initial stages of the process development , prekallikrein and kallikrein inhibitor were observed to be secreted from the lungs to arterial blood . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
51,
64
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
69,
79
]
} |
the effect was assesed according to the protein specific radioactivity 2 and 3 hours after injection into animals of 14c-protein hydrolysate of chlorella . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
40,
47
]
} | {
"id": "C0033631",
"name": "protein hydrolysate",
"pos": [
121,
140
]
} |
growth , interleukin-2 production , and responsiveness to il-2 in t4-positive t lymphocyte populations from malignant cutaneous t cell lymphoma ( sezary 's syndrome ) : the effect of cyclosporin a . | NA | {
"id": "C0079773",
"name": "t",
"pos": [
4,
5
]
} | {
"id": "C0036920",
"name": "sezary 's",
"pos": [
146,
155
]
} |
conversion of hemoglobin to carboxy-hemoglobin increased an-mediated lp , whereas conversion to met-hemoglobin decreased an-mediated lp . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
14,
24
]
} | {
"id": "C0025635",
"name": "met-hemoglobin",
"pos": [
96,
110
]
} |
increased amounts of phosphatidylcholine ( pc ) and cholesterol were found in the membrane lipids of the affected patient , despite normal plasma lipids . | NA | {
"id": "C0025249",
"name": "membrane",
"pos": [
82,
90
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
146,
152
]
} |
the nature of cytoplasmic anae enzymes was further characterised in 20 cases by isoelectrophoretic analysis of anae isoenzymes . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
31,
38
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
116,
126
]
} |
in particular , the results of this study indicate the lack of discriminatory value of anae cytochemistry in the differentiation of aml from other acute leukaemias of non-monocytic type . | NA | {
"id": "C0023467",
"name": "aml",
"pos": [
132,
135
]
} | {
"id": "C0023465",
"name": "acute leukaemias",
"pos": [
147,
163
]
} |
3-mercaptopropionic acid also prevented these pharmacological actions induced by eda without affecting responses to gaba , 3-aminopropranesulphonic acid , muscimol , baclofen or the twitch responses to transmural stimulation . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
116,
120
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
166,
174
]
} |
uptake was strictly na+-independent but was energy-dependent , and inhibited by 2 , 4'-dinitrophenol ( 2 , 4'-dnp ) and cooling ( 0-4 degrees c ) . | NA | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
87,
100
]
} | {
"id": "C0045511",
"name": "dnp",
"pos": [
110,
113
]
} |
adrenaline ( 5-10 micrograms kg-1 ) , noradrenaline ( 5-20 micrograms kg-1 ) and isoprenaline ( 40-50 micrograms kg-1 ) which depressed spontaneous urinary bladder activity , were antagonized by the beta-receptor blocking agent propranolol ( 1 mg kg-1 ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} |
the effects of adenosine , adenosine analogues ( n6-cyclohexyladenosine ( cha ) , l-n6-phenylisopropyladenosine ( l-pia ) , d-n6-phenylisopropyladenosine ( d-pia ) , n6-methyladenosine and 2-chloroadenosine ) , adenine , inosine , hypoxanthine , cyclic amp and its analogue the dibutyryl cyclic amp ( db cyclic amp ) , and methylxanthines ( theophylline , caffeine and isobutylmethylxanthine ( ibmx ) on compound action potentials were investigated in de-sheathed sciatic nerve preparations of the frog . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
15,
24
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
129,
153
]
} |
the effects of adenosine , adenosine analogues ( n6-cyclohexyladenosine ( cha ) , l-n6-phenylisopropyladenosine ( l-pia ) , d-n6-phenylisopropyladenosine ( d-pia ) , n6-methyladenosine and 2-chloroadenosine ) , adenine , inosine , hypoxanthine , cyclic amp and its analogue the dibutyryl cyclic amp ( db cyclic amp ) , and methylxanthines ( theophylline , caffeine and isobutylmethylxanthine ( ibmx ) on compound action potentials were investigated in de-sheathed sciatic nerve preparations of the frog . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
15,
24
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
189,
206
]
} |
the effects of adenosine , adenosine analogues ( n6-cyclohexyladenosine ( cha ) , l-n6-phenylisopropyladenosine ( l-pia ) , d-n6-phenylisopropyladenosine ( d-pia ) , n6-methyladenosine and 2-chloroadenosine ) , adenine , inosine , hypoxanthine , cyclic amp and its analogue the dibutyryl cyclic amp ( db cyclic amp ) , and methylxanthines ( theophylline , caffeine and isobutylmethylxanthine ( ibmx ) on compound action potentials were investigated in de-sheathed sciatic nerve preparations of the frog . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
278,
298
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
304,
314
]
} |
the order of potencies was : cha greater than d-pia greater than l-pia greater than n6-methyladenosine greater than 2-chloroadenosine greater than adenosine . | NA | {
"id": "C0031484",
"name": "l-pia",
"pos": [
65,
70
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
147,
156
]
} |
in the cat , intravenous infusions of octadecyl-agpc , which produce a hypotensive response , did not attenuate nictitating membrane contractions in vivo in response to intravenous injections of na , adrenaline ( ad ) or to electrical stimulation of the postganglionic fibres of the superior cervical ganglion . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
195,
197
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
200,
210
]
} |
phentolamine , on the other hand , attenuated nictitating membrane contractions and blood pressure responses to ad or na . | NA | {
"id": "C0014563",
"name": "ad",
"pos": [
112,
114
]
} | {
"id": "C0028351",
"name": "na",
"pos": [
118,
120
]
} |
the effectiveness of alpha-adrenoceptor blockade under these experimental conditions was monitored with intravenous na and ad . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
116,
118
]
} | {
"id": "C0014563",
"name": "ad",
"pos": [
123,
125
]
} |
when applied iontophoretically , all four substances enhanced the depressant actions of iontophoretically applied adenosine but did not affect the depressant actions of the uptake-resistant analogue , adenosine 5'-n-ethylcarboxamide ( neca ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
114,
123
]
} | {
"id": "C0050789",
"name": "adenosine 5",
"pos": [
201,
212
]
} |
the p1-purinoceptor blocker , aminophylline , attenuates adenosine-induced vasodilatation , but it does not affect the vasodilatation produced by atp or hypothalamic stimulation . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
57,
66
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
146,
149
]
} |
three of the non-anorexia co-twins had other psychiatric illnesses , and two had minor eating disorders . | NA | {
"id": "C0004936",
"name": "psychiatric illnesses",
"pos": [
45,
66
]
} | {
"id": "C0013473",
"name": "eating disorders",
"pos": [
87,
103
]
} |
in this case , the two syndromes are descriptions of a specific delusional content , and occur as part of the psychopathology within a schizophrenic disorder , rather than as distinct disease entities . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
23,
32
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
184,
191
]
} |
we have reviewed all cases of perforated peptic ulcer in oxford over the last 18 years ( 1965-82 ) to see if a similar change in the incidence of this major complication of peptic ulceration has occurred . | NA | {
"id": "C0030925",
"name": "perforated peptic ulcer",
"pos": [
30,
53
]
} | {
"id": "C0030920",
"name": "peptic ulceration",
"pos": [
173,
190
]
} |
immune-deprived mice bearing hx99 human breast carcinoma xenografts were injected with a radiolabelled monoclonal antibody , licr-lon-m8 ( m8 ) , to investigate the dependence of tumour localization on ( i ) tumour site and ( ii ) antibody radiolabel . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
103,
122
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
231,
239
]
} |
the use of beta adrenoceptor blockade in the treatment of rest angina is controversial , and the effects on severe angina of partial agonist activity in beta blockers are unknown . | NA | {
"id": "C0002965",
"name": "rest angina",
"pos": [
58,
69
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
115,
121
]
} |
ambulatory electrocardiography showed arrhythmia in seven patients , extrasystoles in six , and normal findings in seven . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
38,
48
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
69,
82
]
} |
late deaths from breast cancer may , however , have often been the result of metastases from second primaries rather than the late manifestation of micrometastases from the original primary carcinoma . | NA | {
"id": "C0027627",
"name": "metastases",
"pos": [
77,
87
]
} | {
"id": "C1513276",
"name": "micrometastases",
"pos": [
148,
163
]
} |
minimum inhibitory concentrations ( mics ) of penicillin , ampicillin , tetracycline , cefoxitin , cefuroxime , cefotaxime , sulphamethoxazole-trimethoprim ( ratio 19/1 ) , and spectinomycin , were measured for 100 strains by the agar dilution method . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
99,
109
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
112,
122
]
} |
none of the trout myelin proteins react with anti-rat cns myelin proteolipid protein ( plp ) antiserum . | NA | {
"id": "C0026972",
"name": "myelin proteins",
"pos": [
18,
33
]
} | {
"id": "C0060617",
"name": "myelin proteolipid protein",
"pos": [
58,
84
]
} |
the effect of serotonin ( 5-ht ) deficiency on hypothalamic-pituitary-adrenal ( hpa ) activity was investigated by using 5,7-dihydroxytryptamine ( 5,7-dht ) for the selective destruction of central 5-ht neurons , and corticosterone response to suppression by dexamethasone as the index of hpa activity . | NA | {
"id": "C0020635",
"name": "deficiency",
"pos": [
33,
43
]
} | {
"id": "C0032002",
"name": "hpa",
"pos": [
289,
292
]
} |
proinsulin was effective in doses 30-fold greater than insulin , whereas desoctapeptide insulin had little or no effect . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
0,
10
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
88,
95
]
} |
the sensitivities in the brain of the barbiturates n-methyl-cyclobarbital ( mcb ) and hexobarbital ( hex ) were determined by an anesthesia threshold in male rats . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
38,
50
]
} | {
"id": "C0019469",
"name": "hexobarbital",
"pos": [
86,
98
]
} |
the action of baclofen , a gaba analog , was studied at the crayfish neuromuscular junction ( nmj ) . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
14,
22
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
27,
31
]
} |
the 4 most abundant neuropeptides derived from pre-prosomatostatin ( pre-pross ) and presently characterized are : somatostatin-14 , somatostatin 28 ( 1-12 ) , somatostatin 28 and pre-pross25-100 . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
115,
130
]
} | {
"id": "C0074854",
"name": "somatostatin 28",
"pos": [
160,
175
]
} |
the proteolysis of the chromatin core particle by the arginine-specific endopeptidase clostripain yields a new nucleoprotein particle containing an unaltered dna fragment of about 145 base pairs in length and a protein octameric core made up of twice the four histone fragments h2a , h2b , h3 and h4 . | NA | {
"id": "C0008546",
"name": "chromatin",
"pos": [
23,
32
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
111,
124
]
} |
the proteolysis of the chromatin core particle by the arginine-specific endopeptidase clostripain yields a new nucleoprotein particle containing an unaltered dna fragment of about 145 base pairs in length and a protein octameric core made up of twice the four histone fragments h2a , h2b , h3 and h4 . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
111,
124
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
211,
218
]
} |
this restores the synchronous beatings of the myocardial cells , the viability of which is then even improved while they grow in the absence of fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
14,
17
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
144,
155
]
} |
exacerbation of rickets and osteomalacia by maize : a study of bone histomorphometry and composition in young baboons . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
16,
23
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
28,
40
]
} |
although both groups fed the vitamin d-free diets developed rickets and osteomalacia , the group receiving maize did so far more rapidly and to a much greater degree of severity , as evidenced by clinical , radiological , biochemical , and histological signs . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
60,
67
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
72,
84
]
} |
the alpha 1-adrenoreceptor agonist phenylephrine potentiated the in vivo thermogenic response of bat to isoproterenol or to a suboptimal dose of na and enhanced the release of camp elicited by these catecholamines . | NA | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
104,
117
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
199,
213
]
} |
amoxapine , a member of the dibenzoxazepine drugs which includes loxapine , has recently been introduced for the treatment of depression . | NA | {
"id": "C0002644",
"name": "amoxapine",
"pos": [
0,
9
]
} | {
"id": "C0024056",
"name": "loxapine",
"pos": [
65,
73
]
} |
the human neoplastic cells used were hela ( uterine cervical cancer ) and wi-38 ct-1 ( embryonic lung fibroblasts transformed in culture by 60co gamma ray ) cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
102,
113
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
157,
162
]
} |
however , the antibody content of the cics was isotypically restricted to immunoglobulin g2b and immunoglobulin g3 regardless of the tumor type . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
14,
22
]
} | {
"id": "C0003313",
"name": "cics",
"pos": [
38,
42
]
} |
this serial study indicates that the use of non-antigen-specific assays for cics without regard to tumor burden or possible antibody isotypic restriction may be misleading , and that cic levels can indeed correlate with metastatic tumor burden . | NA | {
"id": "C0003313",
"name": "cics",
"pos": [
76,
80
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
124,
132
]
} |
mdl 72175 depleted putrescine and spermidine levels in the tumors to the same extent as did alpha-difluoromethylornithine . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
19,
29
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
45,
51
]
} |
hybridoma colonies were screened against small cell lung carcinoma cells and normal lung fibroblasts with an enzyme-linked immunosorbent assay . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
67,
72
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
89,
100
]
} |
assay of serum total cholesterol and triglycerides showed that consumption of 23 % corn oil diet significantly depressed serum cholesterol ( but not triglyceride ) levels compared to the lf:5 % corn oil- and the hf : mct-containing diets . | NA | {
"id": "C0041004",
"name": "triglycerides",
"pos": [
37,
50
]
} | {
"id": "C0724624",
"name": "mct",
"pos": [
217,
220
]
} |
in p388/dox cells treated for 3 hr , cytotoxic effects ( based on colony formation in soft agar ) of daunorubicin ( dau ) in the presence of trifluoperazine ( tfp ) were dau concentration-dependent and enhanced 2- to 100-fold . | NA | {
"id": "C0013089",
"name": "dox",
"pos": [
8,
11
]
} | {
"id": "C0011015",
"name": "dau",
"pos": [
170,
173
]
} |
additionally , in the presence of tfp , on a molar basis , equitoxic doses of dau were 4-fold lower than dox for p388/dox cells . | NA | {
"id": "C0011015",
"name": "dau",
"pos": [
78,
81
]
} | {
"id": "C0013089",
"name": "dox",
"pos": [
118,
121
]
} |
in dox-sensitive ( p388/s ) p388 mouse leukemia cells treated for 3 hr , some enhancement in the cytotoxic effects due to tfp were observed with dau and dox but not with acm , ad32 , or n-trifluoroacetyladriamycin . | NA | {
"id": "C0011015",
"name": "dau",
"pos": [
145,
148
]
} | {
"id": "C0013089",
"name": "dox",
"pos": [
153,
156
]
} |
in contrast , dau accumulation in p388/s cells was 4-fold higher than in similarly treated p388/dox cells , and the 2- and 4-fold increase due to tfp in the accumulation and retention , respectively , of dau in p388/dox cells was not observed in p388/s cells . | NA | {
"id": "C0011015",
"name": "dau",
"pos": [
14,
17
]
} | {
"id": "C0013089",
"name": "dox",
"pos": [
216,
219
]
} |
results from this study indicate that in p388/dox cells , the calmodulin inhibitor tfp is more effective with dau than dox , significantly less effective with acm , and ineffective with ad32 and n-trifluoroacetyladriamycin . | NA | {
"id": "C0011015",
"name": "dau",
"pos": [
110,
113
]
} | {
"id": "C0013089",
"name": "dox",
"pos": [
119,
122
]
} |
when mouse peritoneal exudate cells were used , fcr for all igg isotypes were easily detected , and all igg isotypes mediated adcc . | NA | {
"id": "C0020852",
"name": "igg",
"pos": [
60,
63
]
} | {
"id": "C0021017",
"name": "igg isotypes",
"pos": [
104,
116
]
} |
the mr 47,000 protein , a monomeric regulatory subunit of type i kinase , was clearly the dominant protein in tumor specimens , but it was much less abundant in normal kidney . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
14,
21
]
} | {
"id": "C0027642",
"name": "protein",
"pos": [
99,
106
]
} |
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