text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the nitrite lowering effect of ascorbic acid appears to correlate with the rate of oxidation of the vitamin to dehydroascorbic acid , suggesting that ascorbic acid may be involved in the reduction of nitrite to nitrogen oxide . | NA | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
111,
131
]
} | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
150,
163
]
} |
all 16 isolates were the same serotype and were resistant to amikacin , tobramycin , kanamycin , and gentamicin . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
61,
69
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
85,
94
]
} |
a quantitative evaluation of cerebellar ataxia , with an ataxia score ( total , static , kinetic ) and the measurement of objective values relating to the major symptoms , was used in 21 patients with hereditary ataxias treated for 12 months with high doses ( 16 mg/kg/day ) of d-l-5-htp , l-5-htp or the combination d-l... | NA | {
"id": "C0007758",
"name": "cerebellar ataxia",
"pos": [
29,
46
]
} | {
"id": "C0004134",
"name": "ataxia",
"pos": [
212,
218
]
} |
eight cases of hyperthyroidism and thyroid cancer , representing 0.96 % of overall hyperfunctioning thyroid diseases ( 835 ) , surgically treated are reported . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
15,
30
]
} | {
"id": "C0040128",
"name": "thyroid diseases",
"pos": [
100,
116
]
} |
double heterozygotes for the abnormal hemoglobin and beta-thalassemia with a full complement of 4 alpha-globin structural genes tended to have lower amount of the abnormal hb than heterozygotes for this variant who do not have beta-thalassemia . | NA | {
"id": "C0019047",
"name": "abnormal hemoglobin",
"pos": [
29,
48
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
172,
174
]
} |
rats were treated intraperitoneally with the gold-containing compounds sodium aurothiomalate ( myocrisin ) , sodium aurothiosulfate ( sanocrysin ) , and aurothioglucose . | NA | {
"id": "C0206108",
"name": "gold",
"pos": [
45,
49
]
} | {
"id": "C0037512",
"name": "sodium aurothiosulfate",
"pos": [
109,
131
]
} |
excretion of noradrenaline and adrenaline was investigated in two experiments which included 3 physical test sessions and 3 mental test sessions ( experiment x ) and a week of real-life situations ( experiment y ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
13,
26
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
31,
41
]
} |
we found that the rate of inert gas diffusion through human skin , expressed as conductance ( g , in ml stpd x h-1 x m-2 x atm-1 ) , increases exponentially as a function of blood flow , and was indistinguishable between he and n2 ( g = 21.19 x 100.0124q ) . | NA | {
"id": "C0017112",
"name": "inert gas",
"pos": [
26,
35
]
} | {
"id": "C0018880",
"name": "he",
"pos": [
221,
223
]
} |
fifteen epileptic dogs had been treated with high dosages of phenobarbital but had not achieved adequate control of their seizures . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
8,
17
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
122,
130
]
} |
serum concentrations of phenobarbital were measured in all dogs before and after primidone therapy was initiated , to ensure that the primidone dosage achieved comparable or higher values when derived from primidone . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
24,
37
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
206,
215
]
} |
only one dog experienced improvement in seizure control , indicating that there is no advantage to the use of primidone over the use of phenobarbital for the control of seizures in most dogs . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
110,
119
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
136,
149
]
} |
there was no difference in the mean androgen receptor content ( approximately 10,000 sites/cell ) or binding affinity ( approximately 1 nm ) between the patients ' fibroblasts and those from 26 fibroblast strains established from 26 normal males . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
91,
95
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
194,
204
]
} |
it is a cyclic depsipeptide composed of two mol of d-serine and one mol each of beta-hydroxytetradecanoic acid , l-arginine , d- and l-proline , l-3-hydroxyproline and d- and l-beta-hydroxyaspartic acid . | NA | {
"id": "C0033382",
"name": "l-proline",
"pos": [
133,
142
]
} | {
"id": "C0020388",
"name": "l",
"pos": [
175,
176
]
} |
the susceptibilities of 50 clinical isolates of the bacteroides fragilis group to ampicillin , carbenicillin , mezlocillin , azlocillin and piperacillin were similar , modal mics being 8-32 mg/l . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
82,
92
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
111,
122
]
} |
the susceptibilities of 50 clinical isolates of the bacteroides fragilis group to ampicillin , carbenicillin , mezlocillin , azlocillin and piperacillin were similar , modal mics being 8-32 mg/l . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
82,
92
]
} | {
"id": "C0004499",
"name": "azlocillin",
"pos": [
125,
135
]
} |
the susceptibilities of 50 clinical isolates of the bacteroides fragilis group to ampicillin , carbenicillin , mezlocillin , azlocillin and piperacillin were similar , modal mics being 8-32 mg/l . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
82,
92
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
140,
152
]
} |
however , in the presence of clavulanic acid , 45 and 43 strains became susceptible ( mic less than or equal to 4 mg/l ) to ampicillin and carbenicillin respectively whilst 27 , 37 and 35 strains became susceptible ( mic less than or equal to 4 mg/l ) to mezlocillin , azlocillin and piperacillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
124,
134
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
255,
266
]
} |
however , in the presence of clavulanic acid , 45 and 43 strains became susceptible ( mic less than or equal to 4 mg/l ) to ampicillin and carbenicillin respectively whilst 27 , 37 and 35 strains became susceptible ( mic less than or equal to 4 mg/l ) to mezlocillin , azlocillin and piperacillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
124,
134
]
} | {
"id": "C0004499",
"name": "azlocillin",
"pos": [
269,
279
]
} |
however , in the presence of clavulanic acid , 45 and 43 strains became susceptible ( mic less than or equal to 4 mg/l ) to ampicillin and carbenicillin respectively whilst 27 , 37 and 35 strains became susceptible ( mic less than or equal to 4 mg/l ) to mezlocillin , azlocillin and piperacillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
124,
134
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
284,
296
]
} |
mean serum peak erythromycin concentrations ( standard deviation ) were 4.8 mg/l ( +/- 2.0 ) following 1.5 g erythromycin stearate and 2.8 mg/l ( +/- 1.4 ) after 3.0 g erythromycin ethylsuccinate . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
16,
28
]
} | {
"id": "C0059566",
"name": "erythromycin stearate",
"pos": [
109,
130
]
} |
mean serum peak erythromycin concentrations ( standard deviation ) were 4.8 mg/l ( +/- 2.0 ) following 1.5 g erythromycin stearate and 2.8 mg/l ( +/- 1.4 ) after 3.0 g erythromycin ethylsuccinate . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
16,
28
]
} | {
"id": "C0014810",
"name": "erythromycin",
"pos": [
168,
180
]
} |
both types of erythromycin frequently caused mild gastrointestinal side-effects but there were fewer side-effects associated with erythromycin ethylsuccinate . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
14,
26
]
} | {
"id": "C0014810",
"name": "erythromycin ethylsuccinate",
"pos": [
130,
157
]
} |
however , because of the increased serum erythromycin concentrations between 1 and 6 h after the dose of the stearate preparation compared to ethylsuccinate we recommend erythromycin stearate , 1.5 g , as the preferred loading dose , given 1 h before the dental procedure , for preventing endocarditis in susceptible pat... | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
41,
53
]
} | {
"id": "C0059566",
"name": "erythromycin stearate",
"pos": [
170,
191
]
} |
antistaphylococcal activity of three beta-lactam antibiotics , i.e . cefmenoxime , cefotaxime and latamoxef ( moxalactam ) was compared with that of nafcillin by studying cure rates of aortic valvular endocarditis caused by one of three clinical isolates of staphylococcus aureus in new zealand white male rabbits . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
69,
80
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
83,
93
]
} |
the aortic valve was sterilized in 11 of 15 ( 73 % ) animals treated with cefmenoxime , nine of 13 ( 69 % ) treated with cefotaxime , 11 of 13 ( 85 % ) treated with latamoxef and 12 of 15 ( 80 % ) treated with nafcillin . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
74,
85
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
121,
131
]
} |
treatment of non-complicated urogenital , rectal and oropharyngeal gonorrhoea with intramuscular cefotaxime 1.0 g or cefuroxime 1.5 g . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
97,
107
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
117,
127
]
} |
in an open randomized study in a large rotterdam male and female population ( n = 1500 ) , suffering from uncomplicated urogenital , rectal and oropharyngeal gonorrhoea treatment with cefotaxime 1.0 g proved to be more effective than with cefuroxime 1.5 g in all patients studied . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
184,
194
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
239,
249
]
} |
however , statistically significant differences between the failure rates of the cefotaxime and the cefuroxime treatment were found only for all male and female patients , in urethral or urogenital and rectal infections in this group , for all male patients , and in urethral infections in men . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
81,
91
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
100,
110
]
} |
to date , we have not detected prothrombin time prolongation or a haemorrhagic tendency with cefotaxime , ceftizoxime , cefotiam , cefoxitin or cefsulodin . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
93,
103
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
106,
117
]
} |
to date , we have not detected prothrombin time prolongation or a haemorrhagic tendency with cefotaxime , ceftizoxime , cefotiam , cefoxitin or cefsulodin . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
93,
103
]
} | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
120,
128
]
} |
we analysed the hydrolysis of desacetyl-cefotaxime , in comparison with cefotaxime , by 10 beta-lactamases , mostly cephalosporinases , isolated from various gram-negative species . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
91,
106
]
} | {
"id": "C0728805",
"name": "cephalosporinases",
"pos": [
116,
133
]
} |
we investigated the effects of cefoperazone ( 75 % biliary excretion ) , ceftriaxone ( 45 % ) and cefotaxime ( 5 % ) on the aerobic faecal flora . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
73,
84
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
98,
108
]
} |
injectable antibiotic use in nottingham has shown a change in the past 3 years : the quantity of cefotaxime and cefuroxime prescribed by the end of 1983 was double that of aminoglycosides . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
97,
107
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
112,
122
]
} |
this significant increase in use of cephalosporins has not been accompanied by an increase in bacterial resistance to cefuroxime or cefotaxime . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
118,
128
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
132,
142
]
} |
methods have been developed for separation of folates in their monoglutamyl form by using anion-exchange , paired-ion reverse phase , or conventional reverse phase liquid chromatography ( lc ) . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
90,
95
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
144,
147
]
} |
x-ray powder diffraction data for selected drugs : furosemide , hydrochlorothiazide , naproxen , naproxen sodium , propranolol hydrochloride , and the halopheniramine maleates . | NA | {
"id": "C0027396",
"name": "naproxen",
"pos": [
86,
94
]
} | {
"id": "C0546873",
"name": "naproxen sodium",
"pos": [
97,
112
]
} |
the two substrates exhibited different kinetics of depolymerization , and the oligosaccharide products differed in the amount of noncarbohydrate substituents , indicating that the acidic capsular and excreted extracellular polysaccharides from 5-day-old cultures of r. trifolii 0403 were different . | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
78,
93
]
} | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
223,
238
]
} |
a polysaccharide depolymerase isolated from the phage lysate of rhizobium trifolii 4s was used to fragment capsular polysaccharides ( cps ) and extracellular polysaccharides ( eps ) of r. trifolii 0403 into oligosaccharides . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
116,
131
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
207,
223
]
} |
the intact eps did not bind to clover lectin , although the oligosaccharide fragments from eps did . | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
60,
75
]
} | {
"id": "C0032594",
"name": "eps",
"pos": [
91,
94
]
} |
the cps from 5-day-old cultures , its corresponding oligosaccharide fragments , and the oligosaccharide fragments of eps from 5-day-old cultures , all at a concentration of 2.5 micrograms per seedling , stimulated infection thread formation in root hairs of clover seedlings inoculated with r. trifolii 0403 . | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
52,
67
]
} | {
"id": "C0032594",
"name": "eps",
"pos": [
117,
120
]
} |
thus , this bacteriophage-induced polysaccharide depolymerase converted the acidic cps and eps of r. trifolii 0403 into biologically active oligosaccharides capable of binding trifoliin a and stimulating root hair infection . | NA | {
"id": "C0032594",
"name": "eps",
"pos": [
91,
94
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
140,
156
]
} |
methylammonium transport was not significantly inhibited by a variety of amino acids , primary amines , and polyamines . | NA | {
"id": "C0002508",
"name": "amines",
"pos": [
95,
101
]
} | {
"id": "C0032433",
"name": "polyamines",
"pos": [
108,
118
]
} |
the sulfydryl reagent p-chloromercuribenzoic acid and the heavy metal thallium also inhibited uptake , suggesting the presence of an nh4+-specific permease . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
58,
69
]
} | {
"id": "C0039738",
"name": "thallium",
"pos": [
70,
78
]
} |
this is apparently sufficient since a spontaneous mutant , designated fp9 , resistant to the growth-inhibitory phenylalanine analog p-fluorophenylalanine contained a feedback-resistant dahp synthase-phe and cross-fed a phenylalanine auxotroph of bacillus subtilis . | NA | {
"id": "C0030137",
"name": "p-fluorophenylalanine",
"pos": [
132,
153
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
219,
232
]
} |
mutants of escherichia coli with deletions of the recb and recc genes were obtained by two methods using transposable dna elements . | NA | {
"id": "C0012868",
"name": "transposable",
"pos": [
105,
117
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
118,
121
]
} |
cellobiose ( usually considered to be a cellulase inducer ) caused a sharp decrease in camp levels and repressed eg production when added to cellulose-grown cultures . | NA | {
"id": "C0007630",
"name": "cellobiose",
"pos": [
0,
10
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
141,
150
]
} |
the formation of the d-amino acid-peptidoglycan linkage was insensitive to beta-lactam antibiotics such as benzylpenicillin and ampicillin ( 500 micrograms/ml ) and therefore was not due to the reaction of dd-transpeptidation which is involved in the biosynthesis of peptidoglycan . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
107,
123
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
128,
138
]
} |
hemagglutinin activity , however , was detected in culture supernatant , and this observation suggests that fimbriae of a different type or a lectin-like protein may be acting as hemagglutinin in b. gingivalis . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
142,
148
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
154,
161
]
} |
the hydrophobic , putative lipid a fraction of lps i and lps ii contained the above constituents , but the hydrophilic fraction was devoid of ethanolamine . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
27,
34
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
57,
60
]
} |
these results suggest that dmso increases the affinity of f1 and pi and shifts the equilibrium from the enzyme-adp-pi complex to the enzyme-atp complex during the atp synthesis . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
104,
110
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
133,
139
]
} |
in the condensation reaction , n-acetylglucosamine , n-acetylgalactosamine , glucosamine , and galactosamine could not replace n-acetylmannosamine as substrate , and phosphoenolpyruvate , lactate , beta-hydroxypyruvate , and other pyruvate derivatives could not replace pyruvate as substrate . | NA | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
31,
50
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
77,
88
]
} |
in the condensation reaction , n-acetylglucosamine , n-acetylgalactosamine , glucosamine , and galactosamine could not replace n-acetylmannosamine as substrate , and phosphoenolpyruvate , lactate , beta-hydroxypyruvate , and other pyruvate derivatives could not replace pyruvate as substrate . | NA | {
"id": "C0001055",
"name": "n-acetylgalactosamine",
"pos": [
53,
74
]
} | {
"id": "C0016943",
"name": "galactosamine",
"pos": [
95,
108
]
} |
in amino acid analysis , tas-1d3 was distinctive in having proline as a dominant amino acid , and in that it lacked basic amino acids , sulfur-containing amino acids and aromatic amino acids . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
116,
133
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
179,
184
]
} |
bovine plasma inhibitor was shown to be a lipoprotein containing phosphatidylcholine , sphingomyelin , cholesterol ester , and triacyl glycerol as major lipid components . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
42,
53
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
153,
158
]
} |
from the cross-reaction of diiia to rabbit anti-gi-rep and anti-ei-m sera in vitro , it was confirmed that the antigen carried essentially the same antigenic determinant as gi-rep and ei-m , and this was termed type alpha determinant . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
111,
118
]
} | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
148,
169
]
} |
the lanthanide ions lu3+ ( diamagnetic ) and gd3+ ( paramagnetic broadening probe ) were used to displace ca2+ from the high-affinity cation binding site on g-actin . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
15,
19
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
134,
140
]
} |
other inositol phosphates ( inositol 1,4-bisphosphate , inositol 1-phosphate , inositol hexaphosphate , and myo-inositol ) had no effect on protein phosphorylation at 10 ( -6 ) m , although inositol 1,4-bisphosphate at higher concentrations enhanced phosphorylation of the 62-kda protein in brain lysates . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
6,
25
]
} | {
"id": "C0031855",
"name": "inositol hexaphosphate",
"pos": [
79,
101
]
} |
other inositol phosphates ( inositol 1,4-bisphosphate , inositol 1-phosphate , inositol hexaphosphate , and myo-inositol ) had no effect on protein phosphorylation at 10 ( -6 ) m , although inositol 1,4-bisphosphate at higher concentrations enhanced phosphorylation of the 62-kda protein in brain lysates . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
6,
25
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
190,
198
]
} |
the response of hepatic glycogen levels to an intravenous injection of the hormone glucagon was continuously monitored through the glycogen c-1 carbon resonance intensity ; | NA | {
"id": "C0023902",
"name": "hepatic glycogen",
"pos": [
16,
32
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
131,
139
]
} |
the protein is composed of 211 amino acids with the composition 3 aspartic acids , 6 asparagines , 13 threonines , 21 serines , 7 glutamic acids , 7 glutamines , 15 prolines , 14 glycines , 37 alanines , 11 valines , 1 methionine , 3 isoleucines , 14 leucines , 1 tyrosine , 1 phenylalanine , 42 lysines , 15 arginines a... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
31,
42
]
} | {
"id": "C0017890",
"name": "glycines",
"pos": [
179,
187
]
} |
the protein is composed of 211 amino acids with the composition 3 aspartic acids , 6 asparagines , 13 threonines , 21 serines , 7 glutamic acids , 7 glutamines , 15 prolines , 14 glycines , 37 alanines , 11 valines , 1 methionine , 3 isoleucines , 14 leucines , 1 tyrosine , 1 phenylalanine , 42 lysines , 15 arginines a... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
31,
42
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
433,
440
]
} |
the 32p incorporated into the phosphoprotein could be chased with unlabeled atp and the protein-phosphate bond was unstable at alkaline ph suggesting an acylphosphate atpase intermediate like that previously characterized in other ( ca2+-mg2+ ) -atpases . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
30,
44
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
88,
95
]
} |
addition of cis-unsaturated fatty acids to this loading medium ( either oleate , linoleate , linolenate , or eicosadienoate ) resulted in a substantial increase in cellular triglyceride content ( greater than 7 times non-fatty acid-treated ) , cellular cholesteryl esters in a liquid state , and a rate of cholesteryl es... | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
16,
39
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
221,
231
]
} |
addition of a saturated fatty acid ( palmitate ) or a fatty acid with a trans-double bond ( elaidate ) to the cholesterol loading media had little effect on cellular triglyceride content , cholesteryl ester physical state , or the rate of cholesteryl ester clearance . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
110,
121
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
239,
256
]
} |
in order to investigate the nature of hdl3-cell association , we studied the interaction of 125i-hdl3 with porcine aortic endothelial cells , rabbit aortic smooth muscle cells , and normal human skin fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
24,
27
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
200,
211
]
} |
furthermore , both 125i-hdl3 and 125i-t-hdl3 association with fibroblasts preincubated with varying concentrations of cholesterol increased in parallel with the free cholesterol content of the cells ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
62,
73
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
193,
198
]
} |
a very similar peptide can also be seen in the amino acid sequence of the slime mold lectin discoidin i , which itself appears to be the product of a gene duplication . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
85,
91
]
} | {
"id": "C0033684",
"name": "product",
"pos": [
137,
144
]
} |
other components of bee venom show specificity for the mcd peptide-binding site , suggesting that a class of neurotoxins in bee venom ( possibly including secapin and tertiapin , but not apamin ) share the specific action of mcd peptide on the central nervous system . | NA | {
"id": "C0004920",
"name": "bee venom",
"pos": [
20,
29
]
} | {
"id": "C0003521",
"name": "apamin",
"pos": [
187,
193
]
} |
n-bromoacetylethanolamine phosphate and 3-bromo-1,4-dihydroxy-2-butanone 1,4-bisphosphate have been tested in order to study the hexose phosphate binding sites of a bifunctional enzyme , fructose-6-p,2-kinase : fructose-2,6-bisphosphatase . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
129,
135
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
211,
219
]
} |
these results strongly suggest that hexose phosphate binding sites of fructose-6-p,2-kinase and fructose-2,6-bisphosphatase are distinct and located in different regions of this bifunctional enzyme . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
36,
42
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
96,
104
]
} |
an iron-sulfur protein has been purified from beef heart ubiquinol-cytochrome c oxidoreductase ( complex iii ) of the mitochondrial respiratory chain by phenyl-sepharose column chromatography and sephacryl s-200 gel chromatography . | NA | {
"id": "C0022095",
"name": "iron-sulfur protein",
"pos": [
3,
22
]
} | {
"id": "C1176474",
"name": "ubiquinol-cytochrome c",
"pos": [
57,
79
]
} |
to elucidate the role of individual amino acid residues in stabilizing the conformation of a protein , the stabilities of wild-type tryptophan synthase alpha-subunit from escherichia coli and seven mutant proteins substituted by single amino acid residues at position 49 , which is buried in the interior of the protein ... | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
198,
213
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
312,
319
]
} |
the mutant proteins have gln , met , val , tyr , leu , ser , or lys in place of glu in the wild-type protein . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
4,
19
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
101,
108
]
} |
the dissociation constant , pk , of the glu residue at position 49 for the wild-type protein was determined to be 7.5 from a titration curve obtained by comparison of two-dimensional isoelectric focusing electrophoresis of the wild-type and mutant proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
85,
92
]
} | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
241,
256
]
} |
the partially purified proteins resembled similar thioredoxins found in spinach chloroplasts and were designated thioredoxin f ( tf ) for the fraction most effective in activating spinach fru-p2-ase and thioredoxin m ( tm ) for the fraction most effective in activating spinach nadph-malate dehydrogenase . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
23,
31
]
} | {
"id": "C0039938",
"name": "thioredoxins",
"pos": [
50,
62
]
} |
the nucleotide homologies as well as the similarities of intron positions of the two trypsin genes to those of other serine protease genes clearly support an evolutionary relationship between members of this gene family . | NA | {
"id": "C0041236",
"name": "trypsin",
"pos": [
85,
92
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
117,
132
]
} |
the number and location of the intron/exon junctions of the chymotrypsin gene as compared to those of other serine protease genes , as well as the location of the genes on separate chromosomes , suggest that the duplication that resulted in the formation of the chymotrypsin gene was an ancient evolutionary event . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
108,
123
]
} | {
"id": "C0008742",
"name": "chymotrypsin",
"pos": [
262,
274
]
} |
limited amino acid sequence information was obtained on rabbit muscle creatine phosphokinase and this was the basis for design and synthesis of two oligonucleotide probes complementary to a creatine kinase cdna sequence which encodes a pentapeptide . | NA | {
"id": "C0010291",
"name": "muscle creatine phosphokinase",
"pos": [
63,
92
]
} | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
190,
205
]
} |
the 64-68-kda doublet was immunoreactive with antiserum directed against bowes melanoma tissue plasminogen activator but not with antiurokinase antibodies . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
46,
55
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
144,
154
]
} |
the ability of hemoglobin ( myoglobin ) to reduce directly low-molecular-weight complexes of fe ( iii ) to form methemoglobin ( metmyoglobin ) and the fe ( ii ) -tris ( 2,2'-bipyridine ) complex under aerobic conditions is described . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
15,
25
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
112,
125
]
} |
the ability of hemoglobin ( myoglobin ) to reduce directly low-molecular-weight complexes of fe ( iii ) to form methemoglobin ( metmyoglobin ) and the fe ( ii ) -tris ( 2,2'-bipyridine ) complex under aerobic conditions is described . | NA | {
"id": "C0027078",
"name": "myoglobin",
"pos": [
28,
37
]
} | {
"id": "C0025852",
"name": "metmyoglobin",
"pos": [
128,
140
]
} |
by comparison of the amino acid analysis and nh2-terminal residue of each isolated peptide with the known amino acid sequence of the enzyme , the peptides were identified as leu-gly-arg-lys ( cbs ) and ile-gly-his-tyr ( cbs ) -asp . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
21,
31
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
206,
209
]
} |
in experiments carried out with phenylalanine in which all five hydrogens on the aromatic ring have been replaced with deuterium , and in the presence of tetrahydrobiopterin , we have been unable to detect a kinetic isotope effect with either the native hydroxylase or with the hydroxylase activated by limited proteolys... | NA | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
64,
73
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
119,
128
]
} |
[ 32p ] pyrophosphate was not detected with the water-soluble product even when 1 mm sodium pyrophosphate was added to impede pyrophosphatase activity . | NA | {
"id": "C0034320",
"name": "pyrophosphate",
"pos": [
8,
21
]
} | {
"id": "C0074764",
"name": "sodium pyrophosphate",
"pos": [
85,
105
]
} |
a na+ gradient ( extravesicular greater than intravesicular ) increased the rate of inorganic sulfate ( so24- ) uptake into renal brush-border membrane vesicles and energized the transient accumulation of the anion against its concentration gradient , indicating a secondary active transport system . | NA | {
"id": "C0038720",
"name": "inorganic sulfate",
"pos": [
84,
101
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
209,
214
]
} |
the steady-state concentration of the azo anion radical and the arsenazo iii-stimulated cyanide-insensitive oxygen consumption were enhanced by calcium and magnesium , suggesting that , in addition to an enhanced azo anion radical-stabilization by complexation with the metal ions , enhanced reduction of arsenazo iii al... | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
88,
95
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
217,
222
]
} |
the steady-state concentration of the azo anion radical and the arsenazo iii-stimulated cyanide-insensitive oxygen consumption were enhanced by calcium and magnesium , suggesting that , in addition to an enhanced azo anion radical-stabilization by complexation with the metal ions , enhanced reduction of arsenazo iii al... | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
42,
47
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
276,
280
]
} |
nevertheless , wild-type and mutant cells could salvage adenine and utilize adenine as a purine source equally efficiently , suggesting that the adenine deaminase-hypoxanthine-guanine phosphoribosyl-transferase pathway plays an important role in promastigote adenine metabolism . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
56,
63
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
89,
95
]
} |
greater than 87 % of platelet-bound radioactivity migrated as thrombin-cleaved a-chains ( a'-chains ) in sodium dodecyl sulfate-polyacrylamide gels indicating that factor xiiia but not factor xiii binds to platelets . | NA | {
"id": "C0015533",
"name": "factor xiiia",
"pos": [
164,
176
]
} | {
"id": "C0015528",
"name": "factor xiii",
"pos": [
185,
196
]
} |
cell growth following testosterone was preceded by a 4-fold increase between 0-12 h in total cellular rna signifying a large increase in rrnas . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
102,
105
]
} | {
"id": "C0035701",
"name": "rrnas",
"pos": [
137,
142
]
} |
the protein exists in the cell as a phosphoprotein and 32p is released coincident with the molecular weight change . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
36,
50
]
} |
measurement of k+ and cl-diffusion potentials using 3,3-dipropylthiadicarboxocyanine iodide as a potential sensitive dye showed that both resting and stimulated vesicles developed k+ gradient-dependent potentials in the presence of an impermeant anion , but that cl- gradient-dependent potentials were observed only in t... | NA | {
"id": "C0021966",
"name": "iodide",
"pos": [
85,
91
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
246,
251
]
} |
this predicted sequence corresponds to an antifreeze protein of intermediate size which is one 11-amino acid repeat longer than the smallest antifreeze proteins found in the serum of winter flounder during the cold season . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
53,
60
]
} | {
"id": "C0103575",
"name": "antifreeze proteins",
"pos": [
141,
160
]
} |
operative treatment may , however , be indicated , especially with displaced intra-articular fractures , fractures of the glenoid rim associated with humeral head subluxation , or unstable fractures of the scapular neck . | NA | {
"id": "C0332715",
"name": "intra-articular",
"pos": [
77,
92
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
189,
198
]
} |
at various times , the lipid radioactivity was measured in each of the intracellular organelles , in immunoprecipitable apoprotein a1 , and in materials that floated at buoyant densities similar to those of plasma lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
23,
28
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
214,
226
]
} |
the beta 3 mrna is present in overwhelming amounts in rna from chicken testis suggesting that this gene encodes a flagellar or meiotic spindle tubulin . | NA | {
"id": "C0035696",
"name": "mrna",
"pos": [
11,
15
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
54,
57
]
} |
they were recognized by the same monoclonal antibodies and antibodies raised against purified c1 reacted also with c2 . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
33,
54
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
59,
69
]
} |
the surface compartments involved in the production of the corneal stroma were aligned along the fibroblast axes and the orthogonality of the cell was in register with that of the extracellular matrix . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
97,
107
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
176,
179
]
} |
in this manner , corneal fibroblasts formed collagen fibrils , bundles , and lamellae within a controlled environment and thereby determined the architecture of the corneal stroma by the configuration of the cell and its associated compartments . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
25,
36
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
208,
212
]
} |
when the conversion of radiolabeled proinsulin to insulin was inhibited by replacing arginine and lysine with the aminoacid analogs , canavanine and thialysine , the nonconverted radioactive material remained associated with golgi-derived , coated secretory granules . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
36,
46
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
50,
57
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.