text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
immunofluorescence showed deposits of igg and iga with sc and joining chain and complement at vessel walls in the upper dermis , and sc was deposited at the dermoepidermal junction . | NA | {
"id": "C0020838",
"name": "iga",
"pos": [
46,
49
]
} | {
"id": "C0036538",
"name": "sc",
"pos": [
133,
135
]
} |
these observations suggest that in patients with schonlein-henoch purpura circulating immune complexes containing secretory iga and sc deposits in skin lesions and kidney exist in connection with the initial involvements on the mucous membranes of the respiratory and/or intestinal tracts . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
114,
127
]
} | {
"id": "C0036538",
"name": "sc",
"pos": [
132,
134
]
} |
however , cells made refractory to either ss-14 or ss-28 were not made refractory to the same extent to the other form of somatostatin . | NA | {
"id": "C0074854",
"name": "ss-28",
"pos": [
51,
56
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
122,
134
]
} |
effects of monensin on conversion of proinsulin to insulin and secretion of newly synthesized insulin in isolated rat islets . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
37,
47
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
94,
101
]
} |
within the same low range of monensin concentrations , proteolytic conversion of newly synthesized proinsulin to insulin was also blocked . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
99,
109
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
113,
120
]
} |
the receptor binding characteristics and biologic protency of biosynthetic human proinsulin ( rdna ) were determined in isolated rat adipocytes and compared with those of insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
81,
91
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
171,
178
]
} |
in competition with 125i ( a14 ) -iodoinsulin for binding to adipocyte receptors at 15 degrees c , proinsulin showed a 100-fold lower affinity for binding than did insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
99,
109
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
164,
171
]
} |
a proinsulin concentration of 3.2 +/- 0.8 x 10 ( -7 ) m was required for 50 % inhibition of tracer binding as compared with a concentration of 1.7 +/- 0.3 x 10 ( -9 ) m for insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
2,
12
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
173,
180
]
} |
glucose incorporation into lipid was half-maximal at a proinsulin concentration of 1.5 +/- 0.4 x 10 ( -8 ) m , whereas the same response was observed at an insulin concentration of 5.2 +/- 1 x 10 ( -11 ) m . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
55,
65
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
156,
163
]
} |
the time course over which insulin and proinsulin stimulated glucose incorporation into lipid was the same , as was the time course over which the stimulation dissipated after removal of the hormones . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
27,
34
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
39,
49
]
} |
no synergism of insulin and proinsulin stimulation of lipogenesis was observed when fat cells were incubated with submaximal concentrations of the two hormones . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
16,
23
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
28,
38
]
} |
plasma cortisol , epinephrine , and norepinephrine increased significantly from nocturnal nadirs between 4:00 and 6:30 a.m . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
18,
29
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
36,
50
]
} |
we conclude that intestinal fluid secretion caused by bile acids and hydroxy-fatty acids could be controlled partially by ca2+ ion interactions which could include intracellular signal effects of ca2+ on anion permeability of the brush border membrane as well as possible increases in permeability of the tight junctions... | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
40,
43
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
204,
209
]
} |
to determine whether hyperinsulinaemia can cause insulin resistance in man and , if so , whether this occurs at a receptor or post-receptor site , nine normal volunteers were infused with insulin for 6 h at a rate ( 2 mu x kg-1 x min-1 ) which resulted in steady-state plasma insulin concentrations of 140 +/- 13 mu/l an... | NA | {
"id": "C0020459",
"name": "hyperinsulinaemia",
"pos": [
21,
38
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
49,
67
]
} |
these results suggest that hyperinsulinaemia can cause insulin resistance in man and that , at least initially , this occurs at a post-receptor site . | NA | {
"id": "C0020459",
"name": "hyperinsulinaemia",
"pos": [
27,
44
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
55,
73
]
} |
the contact materials tested were all potentially suitable for pump reservoirs on engineering criteria and included metals ( stainless steel , titanium and a titanium alloy ) and various plastics ( polypropylene , polytetrafluoroethylene , polyvinylchloride , polyamide , cellulose butyrate and silicone elastomer ) . | NA | {
"id": "C0032167",
"name": "plastics",
"pos": [
187,
195
]
} | {
"id": "C0032582",
"name": "polypropylene",
"pos": [
198,
211
]
} |
the contact materials tested were all potentially suitable for pump reservoirs on engineering criteria and included metals ( stainless steel , titanium and a titanium alloy ) and various plastics ( polypropylene , polytetrafluoroethylene , polyvinylchloride , polyamide , cellulose butyrate and silicone elastomer ) . | NA | {
"id": "C0032167",
"name": "plastics",
"pos": [
187,
195
]
} | {
"id": "C0028736",
"name": "polyamide",
"pos": [
260,
269
]
} |
strong staining of keratin filaments was also seen in 11 human adenocarcinoma cell lines , but it was only seen in a subpopulation of cells in one out of four squamous-cell carcinoma lines and not at all in two normal diploid human epidermal keratinocyte strains . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
134,
139
]
} | {
"id": "C0022567",
"name": "strains",
"pos": [
255,
262
]
} |
this antibody apparently does not recognize its antigen in the presence of sodium dodecyl sulfate ( sds ) because brief exposure of methanol-fixed cells to 0.1 % sds reversibly inhibited the binding of the h10-1 monoclonal antibody to keratin filaments by immunofluorescence , even when the binding of a rabbit polyclona... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
5,
13
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
212,
231
]
} |
spleen cells from c57bl/6 beige mouse showed significantly lower cytotoxic t lymphocyte ( ctl ) generation in vitro against allogeneic target cells as compared with spleen cells from the wild type , whereas the heterozygous littermate showed a response similar to that of the wild type . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
124,
134
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
172,
177
]
} |
in contrast , the responsiveness of beige spleen cells in the mixed lymphocyte reaction against allogeneic stimulator cells was in the normal range , suggesting that beige spleen cells recognize allogeneic stimulator cells to the same extent as spleen cells from normal mouse , resulting in a significant proliferation . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
96,
106
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
252,
257
]
} |
furthermore , larger gas collections within gallstones can be identified since they produce high-level echoes in the acoustic shadow of the stone , probably due to sound reverberation . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
44,
54
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
140,
145
]
} |
phenylethanolamine n-methyltransferase ( pnmt ) is the enzyme that catalyzes the s-adenosyl-l-methionine-dependent methylation of ( - ) norepinephrine to ( - ) epinephrine in the adrenal medulla . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
136,
150
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
160,
171
]
} |
the localization of the earliest replicated chromosomal segment was shown to be unstable , varying from cell to cell in both lymphocytes and fibroblasts of all persons examined . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
104,
108
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
141,
152
]
} |
we have tested possibilities of escherichia coli strains dependent on drugs streptomycin and paromomycin for selection of spontaneous mutations in the rp4 kan gene specifying resistance to aminoglycosids -- kanamycin , neomycin and paromycin . | NA | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
93,
104
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
219,
227
]
} |
in other pndr mutants only catabolising some of purine nucleosides , this catabolisible nucleosides , namely , deoxyinosine , deoxyadenosine as well as , in some cases , inosine and adenosine , act as inducers of pnpase 2 synthesis . | NA | {
"id": "C0034136",
"name": "purine nucleosides",
"pos": [
48,
66
]
} | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
88,
99
]
} |
in other pndr mutants only catabolising some of purine nucleosides , this catabolisible nucleosides , namely , deoxyinosine , deoxyadenosine as well as , in some cases , inosine and adenosine , act as inducers of pnpase 2 synthesis . | NA | {
"id": "C0034136",
"name": "purine nucleosides",
"pos": [
48,
66
]
} | {
"id": "C0021528",
"name": "inosine",
"pos": [
170,
177
]
} |
in other pndr mutants only catabolising some of purine nucleosides , this catabolisible nucleosides , namely , deoxyinosine , deoxyadenosine as well as , in some cases , inosine and adenosine , act as inducers of pnpase 2 synthesis . | NA | {
"id": "C0034136",
"name": "purine nucleosides",
"pos": [
48,
66
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
182,
191
]
} |
since graves ' disease is considered an autoimmune disease , our case represents an example of an association of a severe hereditary deficiency of a contact factor and an autoimmune disease . | NA | {
"id": "C0018213",
"name": "graves",
"pos": [
6,
12
]
} | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
171,
189
]
} |
18 sheep were randomly selected to receive either lmw heparin ( 2 mg/kg ) , high dose heparin ( hd ; 160 u/kg ) , or low dose heparin ( ld ; 60 u/kg ) . | NA | {
"id": "C0019139",
"name": "lmw heparin",
"pos": [
50,
61
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
126,
133
]
} |
the hd heparin yielded the same circulating anti-activated factor x ( anti-xa ) activities as the lmw heparin and the ld heparin yielded the same anti-thrombin activity . | NA | {
"id": "C0019139",
"name": "lmw heparin",
"pos": [
98,
109
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
121,
128
]
} |
lmw heparin and hd heparin were both effective in preventing blood clotting in the ecc circuit , demonstrating the antithrombotic activity of the lmw heparin . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
4,
11
]
} | {
"id": "C0019139",
"name": "lmw heparin",
"pos": [
146,
157
]
} |
clotting in the circuit was observed following ld heparin administration showing that the efficacy of lmw heparin does not only rely upon its weak anti-activated partial thromboplastin time ( aptt ) and anti-thrombin activity . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
50,
57
]
} | {
"id": "C0019139",
"name": "lmw heparin",
"pos": [
102,
113
]
} |
the drugs used were pargyrine , methamphetamine , reserpine , norepinephrine , epinephrine , propranolol , chlorpromazine , 6-hydroxydopamine , haloperidol , pilocarpine , neostigmine and atropine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
62,
76
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
79,
90
]
} |
spontaneous motor activity measured by animex was increased in pups receiving norepinephrine , epinephrine , chlorpromazine , reserpine , propranolol and atropine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
78,
92
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
95,
106
]
} |
1 ) in non-treated rats , epinephrine , isoproterenol and phenylephrine , which were injected intravenously , clearly increased plasma uric acid and allantoin , and norepinephrine had only a slight effect . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
26,
37
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
165,
179
]
} |
the orders of potency to increase plasma uric acid and allantoin were epinephrine greater than isoproterenol greater than phenylephrine greater than norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
70,
81
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
149,
163
]
} |
pharmacological effects of ritodrine hydrochloride ( ritodrine ) , a beta 2-adrenoceptor agonist , were investigated in comparison with that of isoxsuprine hydrochloride ( isoxsuprine ) on the motor nervous system and the central nervous system . | NA | {
"id": "C0356649",
"name": "ritodrine hydrochloride",
"pos": [
27,
50
]
} | {
"id": "C0035661",
"name": "ritodrine",
"pos": [
53,
62
]
} |
pharmacological effects of ritodrine hydrochloride ( ritodrine ) , a beta 2-adrenoceptor agonist , were investigated in comparison with that of isoxsuprine hydrochloride ( isoxsuprine ) on the motor nervous system and the central nervous system . | NA | {
"id": "C0282213",
"name": "isoxsuprine",
"pos": [
144,
155
]
} | {
"id": "C0022267",
"name": "isoxsuprine",
"pos": [
172,
183
]
} |
[ effect of tachycardia on hemodynamics and coronary circulation . different relevance of ventricular tachycardias for healthy persons , coronary patients and patients with left heart hypertrophy ] . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
12,
23
]
} | {
"id": "C0042514",
"name": "ventricular tachycardias",
"pos": [
90,
114
]
} |
thienamycin proved to be most active in vitro , followed by cefotaxim , ceftriaxon , ceftizoxim , ceftazidim and monobactam ; | NA | {
"id": "C0007554",
"name": "cefotaxim",
"pos": [
60,
69
]
} | {
"id": "C0007561",
"name": "ceftriaxon",
"pos": [
72,
82
]
} |
the effects of endogenous plasma renin substrate ( prs ) on the relationship between plasma renin activity ( pra ) and the plasma renin concentration ( prc ) have been studied in hyperthyroid rats , by i-triiodothyronine ( t3 ) administration and in hypothyroid rats , by propylthiouracil ( ptu ) treatment , to clarify ... | NA | {
"id": "C0003017",
"name": "renin substrate",
"pos": [
33,
48
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
382,
393
]
} |
plasma growth hormone ( hgh ) , prolactin ( prl ) , luteinizing hormone ( lh ) , thyroid stimulating hormone ( tsh ) , cortisol and melatonin were determined during a 24 h period in a pubertal boy with a pinealocytoma . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
7,
21
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
24,
27
]
} |
apart from human and porcine insulin all the other peptide standards tested ( thyrotropin-releasing factor , vaso-active intestinal polypeptide , human c-peptide , porcine c-peptide , somatostatin , porcine glucagon , porcine proinsulin and porcine pancreatic polypeptide ) could be separated simultaneously in 40 minute... | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
152,
161
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
226,
236
]
} |
both immunoreactive c-peptide and immunoreactive insulin ( iri ) were recovered in two peaks , the second common peak representing proinsulin and amounting to 6.5 to 8.4 % of total iri . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
20,
29
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
131,
141
]
} |
both immunoreactive c-peptide and immunoreactive insulin ( iri ) were recovered in two peaks , the second common peak representing proinsulin and amounting to 6.5 to 8.4 % of total iri . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
131,
141
]
} | {
"id": "C0021641",
"name": "iri",
"pos": [
181,
184
]
} |
chromatography of plasma extracts from two infants of diabetic mothers demonstrated that proinsulin accounted for 59-63 % of total iri , while insulin was separated into two peaks corresponding to the standards of human insulin and porcine insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
89,
99
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
240,
247
]
} |
chromatography of plasma extracts from two infants of diabetic mothers demonstrated that proinsulin accounted for 59-63 % of total iri , while insulin was separated into two peaks corresponding to the standards of human insulin and porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
92,
99
]
} | {
"id": "C0795635",
"name": "human",
"pos": [
214,
219
]
} |
chromatography of plasma extracts from two infants of diabetic mothers demonstrated that proinsulin accounted for 59-63 % of total iri , while insulin was separated into two peaks corresponding to the standards of human insulin and porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
92,
99
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
232,
247
]
} |
to elucidate the mechanism of vpa-induced hepatotoxicity , the functional and structural changes associated with administration of sodium valproate ( navpa ) to rats ( 200 or 600 mg per kg , i.p . ) were analyzed . | NA | {
"id": "C0042291",
"name": "vpa",
"pos": [
30,
33
]
} | {
"id": "C0037567",
"name": "sodium",
"pos": [
131,
137
]
} |
after alcohol absorption , ethanol elimination was significantly inhibited by both cimetidine ( 3.99 +/- 0.39 vs. 5.68 +/- 0.23 mmoles kg-1 hr-1 , p less than 0.02 ) and ranitidine ( 4.21 +/- 0.14 vs. 5.68 +/- 0.23 mmoles kg-1 hr-1 , p less than 0.02 ) at high ethanol concentrations ( 60 to 20 mm ) but not at blood eth... | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
27,
34
]
} | {
"id": "C0684262",
"name": "blood ethanol concentrations",
"pos": [
311,
339
]
} |
the amino acid at beta 2 of the major components is glutamic acid while glutamine and histidine are found in the minor components . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
52,
65
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
72,
81
]
} |
although glutamic acid , a binding site for atp , does not interact with 2,3-bisphosphoglycerate , glutamine and histidine in the minor components are responsible for the slight effect of 2,3-bisphosphoglycerate on tapir hemoglobin . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
9,
22
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
99,
108
]
} |
the hemolysate obtained from erythrocytes of the adult white stork ( ciconia ciconia ) contains only one hemoglobin component , identified to be hba . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
105,
115
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
145,
148
]
} |
the current prevalence of ntd at birth can be estimated for germany to be about 1.0-1.5 per thousand newborns with about an even distribution to anencephalus and spina bifida . | NA | {
"id": "C0027794",
"name": "ntd",
"pos": [
26,
29
]
} | {
"id": "C0002902",
"name": "anencephalus",
"pos": [
145,
157
]
} |
life span elongation of werner 's syndrome fibroblasts by co-culture with origin-defective sv-40 dna transformed cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
43,
54
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
113,
118
]
} |
co-culturing with origin-defective sv40 dna-injected transformants , we succeeded in activating the limited growth potential of late-phase-ii fibroblasts from patients with werner 's syndrome ( ws cells ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
142,
153
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
197,
202
]
} |
the ratio of collagen types ( i/iii ) in trisomic strains did not differ from the control data while the amount of the degraded procollagen in trisomic cells was increased . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
13,
21
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
128,
139
]
} |
both mabs ig8 and ig10 subsequently demonstrated specificity for mis by their ability to inhibit biologically active mis by precipitation with a second antibody , directly block mis activity in the organ culture assay , and adsorb and elute active mis when coupled to a solid support . | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
5,
9
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
152,
160
]
} |
monoclonal antibodies to tumor-associated antigens ( taa ) of human colorectal cancer were elicited using immunosorbents of lectins combined with peripheral protein extracts of xenografted colon adenocarcinoma . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
124,
131
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
157,
164
]
} |
the improved elicitation of monoclonal antibodies to taa by the use of lectin immunosorbents and peripheral protein extracts has considerable potential for generating reagents useful in diagnosis and therapy of human tumors . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
71,
77
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
108,
115
]
} |
two new monoclonal antibodies to human monocytes and granulocytes : isolation of membrane antigens and lack of effects of antibodies on leukocyte functions in vitro . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
8,
29
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
122,
132
]
} |
t-lymphocytes , b-lymphocytes and natural killer cells can be enumerated with monoclonal antibodies reacting with surface glycoproteins or with antibodies against surface immunoglobulins . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
78,
99
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
144,
154
]
} |
a conjugate of a hapten ( nip ) and a strongly antigenic protein chicken gamma globulin ( cgg ) , when injected in soluble form into mice , induced weak primary responses , as weak as responses induced by conjugates of nip ( or other haptens ) to polysaccharides ficoll or alpha ( -1-6 ) dextran . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
247,
262
]
} | {
"id": "C0016071",
"name": "ficoll",
"pos": [
263,
269
]
} |
membrane sialoglycoprotein ( gp ) of mouse erythrocytes were incorporated into artificial membranes of liposomes which also contained dnp-aminocaproylphosphatidylethanolamine hapten . | NA | {
"id": "C0025256",
"name": "artificial membranes",
"pos": [
79,
99
]
} | {
"id": "C0023828",
"name": "liposomes",
"pos": [
103,
112
]
} |
the conjugate was entrapped in negatively charged , multilamellar phosphatidylcholine ( lecithin ) liposomes in which the polysaccharide remained surface-exposed , at least partially . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
66,
85
]
} | {
"id": "C0031617",
"name": "lecithin",
"pos": [
88,
96
]
} |
these antibodies detect genetic polymorphism of igg3 isotype among wild mice even though there is no polymorphism found among 40 inbred strains tested ( except x-chromosome-linked immunodeficient cba/n strain which lacks igg3 molecules ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
6,
16
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
53,
60
]
} |
cardiac content of ne ( p less than 0.01 ) , and dopeg ( p less than 0.05 ) was significantly lower , whereas doma and nmn were significantly higher ( p less than 0.01 ) in the 1k1c group as compared to controls . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
19,
21
]
} | {
"id": "C0028385",
"name": "nmn",
"pos": [
119,
122
]
} |
although there were no significant changes in arterial plasma norepinephrine ( ne ) concentration at this time ( control = 148 +/- 40 pg/ml ) , arterial plasma epinephrine ( e ) concentration increased threefold ( control 42 +/- 15 pg/ml ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
62,
76
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
160,
171
]
} |
recent developments in the characterization of the adrenergic receptors have led to the identification and purification of the binding subunits of the various catecholamine receptors . beta-adrenergic receptors have been identified in a wide variety of tissues by photoaffinity labeling with the antagonist [ 125i ] p-az... | NA | {
"id": "C0034783",
"name": "adrenergic receptors",
"pos": [
51,
71
]
} | {
"id": "C0054861",
"name": "catecholamine receptors",
"pos": [
159,
182
]
} |
a new management approach to withdrawal has been evaluated , which uses a combination of alpha 1-blockade ( prazosin ) and cardioselective beta-blockade ( atenolol ) together with a benzodiazepine ( chlordiazepoxide ) . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
182,
196
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
199,
215
]
} |
descending tracts emphasized in this symposium originate in the c-1 epinephrine cells of the medulla , b-1 and b-3 serotonin cells of the medulla , and a-5 norepinephrine cells of the pons . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
68,
79
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
156,
170
]
} |
antigenic phenol-phase soluble lipopolysaccharide isolated from brucella abortus 1119-3 by hot phenol-water extraction was shown by sodium dodecyl sulfate-polyacrylamide gel electrophoresis , controlled hydrolysis , periodate oxidation , methylation , and 1h and 13c nuclear magnetic resonance studies to be an s-type li... | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
31,
49
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
371,
378
]
} |
bordetella pertussis infection in mice : correlation of specific antibodies against two antigens , pertussis toxin , and filamentous hemagglutinin with mouse protectivity in an intracerebral or aerosol challenge system . | NA | {
"id": "C0006015",
"name": "bordetella",
"pos": [
0,
10
]
} | {
"id": "C0043167",
"name": "pertussis",
"pos": [
99,
108
]
} |
two monoclonal antibodies , 1b7 and 3f10 , specific for a subunit which has no binding activity to haptoglobin and sheep erythrocytes , named s1 , and one antibody , 1h2 , for a subunit related to the binding activity of the pertussis toxin molecule to haptoglobin or sheep erythrocytes , named s4 , were examined for mo... | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
4,
25
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
155,
163
]
} |
amino acid analysis of the purified dnt revealed that the toxin was composed of characteristically high proportions of glutamic acid , aspartic acid , glycine , proline , alanine , and leucine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
151,
158
]
} |
amino acid analysis of the purified dnt revealed that the toxin was composed of characteristically high proportions of glutamic acid , aspartic acid , glycine , proline , alanine , and leucine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
171,
178
]
} |
these results indicate that certain plant lectins have specificities similar to that of the actinomyces fimbrial lectin and are , therefore , useful probes for identifying receptors on epithelial cells for certain bacteria . | NA | {
"id": "C0304052",
"name": "plant lectins",
"pos": [
36,
49
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
113,
119
]
} |
expression of lipopolysaccharide o antigen in escherichia coli k-12 hybrids containing plasmid and chromosomal genes from shigella dysenteriae 1 . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
14,
32
]
} | {
"id": "C0069180",
"name": "o antigen",
"pos": [
33,
42
]
} |
to establish whether muramyl dipeptide or glycopeptides structurally related to it are formed as a result of macrophage processing of peptidoglycan , bacillus subtilis cell walls radiolabeled in the muramic acid , glucosamine , and alanine residues of the constituent peptidoglycan were incubated in the presence of the ... | NA | {
"id": "C0001060",
"name": "muramyl dipeptide",
"pos": [
21,
38
]
} | {
"id": "C0017953",
"name": "glycopeptides",
"pos": [
372,
385
]
} |
to establish whether muramyl dipeptide or glycopeptides structurally related to it are formed as a result of macrophage processing of peptidoglycan , bacillus subtilis cell walls radiolabeled in the muramic acid , glucosamine , and alanine residues of the constituent peptidoglycan were incubated in the presence of the ... | NA | {
"id": "C0030958",
"name": "peptidoglycan",
"pos": [
134,
147
]
} | {
"id": "C0017953",
"name": "glycopeptides",
"pos": [
372,
385
]
} |
although muramyl dipeptide was not found in the culture medium , at least three glycopeptides structurally related to it were found , namely glcnac-murnac-ala-isogln-dap-ala , glcnac-murnac-ala-isogln-dap , and glcnac-murnac-ala-isogln . | NA | {
"id": "C0001060",
"name": "muramyl dipeptide",
"pos": [
9,
26
]
} | {
"id": "C0017953",
"name": "glycopeptides",
"pos": [
80,
93
]
} |
among them , based on the experiments with commercially available fatty acids , arachidonic acid was the most intensively hemolytic , followed by linoleic , linolenic , oleic , palmitoleic , and myristic acids in that order , whereas palmitic acid showed weak activity only in the presence of divalent cations . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
66,
77
]
} | {
"id": "C0027139",
"name": "myristic acids",
"pos": [
195,
209
]
} |
we compared the sensitivities of oral and nonoral isolates of actinobacillus actinomycetemcomitans , haemophilus segnis , h. aphrophilus , and h. paraphrophilus to the bactericidal action of reagent hydrogen peroxide ( h2o2 ) . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
208,
216
]
} | {
"id": "C0020281",
"name": "h2o2",
"pos": [
219,
223
]
} |
two integral membrane proteins , enzyme iiscr and enzyme iiglc , each specific for its sugar substrate , sucrose or glucose , were identified by their abilities to catalyze specific sugar : sugar-phosphate exchange reactions . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
87,
92
]
} | {
"id": "C0038655",
"name": "sugar-phosphate",
"pos": [
190,
205
]
} |
thus , fraction ai 34 was considered an optimal purified allergen extract of alder pollen , a suitable material for further biochemical characterization and trials on purification of the allergenic reactive antigens . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
187,
197
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
207,
215
]
} |
another control normal cell strain of fibroblasts derived from a human embryo showed a decreased growth rate in the defined medium as compared with that in the df medium with 10 % fbs . | NA | {
"id": "C0007634",
"name": "normal cell",
"pos": [
16,
27
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
38,
49
]
} |
in 5 out of 7 patients with cirrhosis and extensive shunting , plasma concentrations of isosorbide dinitrate after oral administration of 10 mg of the substance were markedly higher than those found in subjects without hepatic disease . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
28,
37
]
} | {
"id": "C0023895",
"name": "hepatic",
"pos": [
219,
226
]
} |
histological examination of the colonies induced indicated the presence of two types of csf , namely csf1 and csf3 , which give rise to pure macrophage and granulocyte colonies respectively . | NA | {
"id": "C0009392",
"name": "csf",
"pos": [
88,
91
]
} | {
"id": "C0079784",
"name": "csf1",
"pos": [
101,
105
]
} |
auranofin , an oral gold preparation , has an effect similar in size and rapidity to that of ifn but , in contrast , the auranofin effect does not require rna synthesis by the effector cells . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
20,
24
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
121,
130
]
} |
when c57bl/6 mouse spleen cells were cultured for 4-5 days , these precultured cells were shown in mixing experiments to suppress the generation of cytotoxic effector cells ( ctl ) against allogeneic p815 cells or the generation of anti-srbc humoral response by freshly explanted c57bl/6 spleen cells . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
189,
199
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
295,
300
]
} |
blood samples taken from a forearm vein revealed that the intake of nahco3 increased resting ph ( 7.34 to 7.41 ) , hco3 ( 27.5 to 31.0 mm ) , and base excess ( 1.1 to 4.6 mm ) . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
68,
74
]
} | {
"id": "C0005367",
"name": "hco3",
"pos": [
115,
119
]
} |
during and following the exercise , blood ph and hco3 were always higher ( p less than 0.05 ) in the nahco3 than placebo trial . | NA | {
"id": "C0005367",
"name": "hco3",
"pos": [
49,
53
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
101,
107
]
} |
antibiotic sensitivity testing revealed the majority of the strains to be penicillin resistant , but sensitive to isoxazolyl-penicillins , clindamycin and lincomycin . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
139,
150
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
155,
165
]
} |
a comparison was made of the ability of either x-radiation or a dna-specific ligand ( the vital bis-benzimidazole dye ; hoechst 33342 ) to induce : cell killing , inhibition of de novo dna synthesis , dna strand breakage and the delay of cell division in human colon adenocarcinoma cells in vitro . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
62,
67
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
201,
204
]
} |
the status of thiamin , riboflavin and pyridoxine in 717 healthy children aged 1-60 months and 569 mothers aged 16-45 years attending a well-baby clinic in bangkok were determined by using the erythrocyte enzymes , transketolase , glutathione oxidoreductase , aspartate aminotransferase and measuring the degree of stimu... | NA | {
"id": "C0034272",
"name": "healthy children",
"pos": [
57,
73
]
} | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
402,
421
]
} |
the status of thiamin , riboflavin and pyridoxine in 717 healthy children aged 1-60 months and 569 mothers aged 16-45 years attending a well-baby clinic in bangkok were determined by using the erythrocyte enzymes , transketolase , glutathione oxidoreductase , aspartate aminotransferase and measuring the degree of stimu... | NA | {
"id": "C0009235",
"name": "coenzymes",
"pos": [
336,
345
]
} | {
"id": "C0039848",
"name": "thiamin pyrophosphate",
"pos": [
346,
367
]
} |
the status of thiamin , riboflavin and pyridoxine in 717 healthy children aged 1-60 months and 569 mothers aged 16-45 years attending a well-baby clinic in bangkok were determined by using the erythrocyte enzymes , transketolase , glutathione oxidoreductase , aspartate aminotransferase and measuring the degree of stimu... | NA | {
"id": "C0009235",
"name": "coenzymes",
"pos": [
336,
345
]
} | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
402,
421
]
} |
the vitamin b6 status of 60 institutionalised elderly subjects ( group a : 31 men , mean age = 77 yr and 29 women , mean age = 84 yr ) and 41 healthy young adults ( group b or control group : 18 men , mean age = 30 yr and 23 women , mean age = 27 yr ) was evaluated using erythrocyte aspartate aminotransferase activity ... | NA | {
"id": "C0034263",
"name": "pyridoxal",
"pos": [
358,
367
]
} | {
"id": "C0087162",
"name": "vitamin",
"pos": [
394,
401
]
} |
four patients administered phenytoin , primidone , phenobarbital , or carbamazepine , alone or in combination , had reduced plasma biotin levels ( less than 250 ng/l ) and an elevated excretion of certain organic acids indicating a possibly decreased activity of propionyl coa carboxylase ( 3-oh-propionate , methylcitra... | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
39,
48
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
51,
64
]
} |
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