text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
treatment with alpha-difluoromethylornithine plus a spermidine analog leads to spermine depletion and growth inhibition in cultured l1210 leukemia cells . | NA | {
"id": "C0037871",
"name": "analog",
"pos": [
63,
69
]
} | {
"id": "C0037874",
"name": "depletion",
"pos": [
88,
97
]
} |
thus , while the spd analog fulfills the role ( s ) of spd in cell proliferation , spm becomes steadily depleted . | NA | {
"id": "C0037871",
"name": "cell proliferation",
"pos": [
62,
80
]
} | {
"id": "C0037874",
"name": "spm",
"pos": [
83,
86
]
} |
the use of dfmo plus a spd analog is proposed as a system for studying the cellular consequences of spm depletion . | NA | {
"id": "C0037871",
"name": "analog",
"pos": [
27,
33
]
} | {
"id": "C0037874",
"name": "depletion",
"pos": [
104,
113
]
} |
the effect of cell culture age and concomitant changes in cell density on the biosynthesis of sulfated-proteoglycan by rabbit articular chondrocytes in secondary monolayer culture was studied . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
14,
18
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
136,
148
]
} |
the glycosaminoglycan chains of a1d1 were hydrodynamically larger in the younger ld cultures than in the older hd cultures and consisted of only chondroitin 6 and 4 sulfate chains . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
4,
21
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
145,
156
]
} |
colony-stimulating factor ( csf-1 ) purified from l-cell-conditioned medium is a haemopoietic growth factor that specifically stimulates the proliferation and differentiation of mononuclear phagocytes . | NA | {
"id": "C0009392",
"name": "csf-1",
"pos": [
28,
33
]
} | {
"id": "C0021757",
"name": "haemopoietic growth factor",
"pos": [
81,
107
]
} |
at 37 degrees c , incubation with unlabelled csf-1 resulted in a `` '' down-regulation ' of the subsequent [ 125i ] csf-1-binding activity by pem in a time- and dose-dependent fashion . | NA | {
"id": "C0009392",
"name": "csf-1",
"pos": [
45,
50
]
} | {
"id": "C0079784",
"name": "] csf-",
"pos": [
114,
120
]
} |
pentoxifylline and its alcohol metabolite ( as the trifluoroacetate ) and the carboxylic acid metabolites ( as ethyl esters ) were measured in separate gas chromatographic steps using a nitrogen detector . | NA | {
"id": "C0007066",
"name": "carboxylic acid",
"pos": [
78,
93
]
} | {
"id": "C0014898",
"name": "esters",
"pos": [
117,
123
]
} |
a high-performance liquid chromatographic method is described for the determination of digoxigenin , digoxigenin monodigitoxoside , digoxigenin bis-digitoxoside , digoxin , and dihydrodigoxin as the 3,5-dinitrobenzoyl esters . | NA | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
87,
98
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
184,
191
]
} |
derivatized digoxigenin , digoxigenin mono- and bis-digitoxoside , and digoxin each yielded one symmetrical peak with the limit of sensitivity of the method being approximately 100 ng/ml . | NA | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
12,
23
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
71,
78
]
} |
a high performance liquid chromatographic ( hplc ) procedure has been developed for the analysis of ascorbic acid and dehydroascorbic acid in complex matrices . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
100,
113
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
118,
138
]
} |
separation is accomplished with an anion-exchange resin and fluorescent detection is achieved through post-column inline chemistry , involving oxidation of ascorbic acid to dehydroascorbic acid followed by reaction with o-phenylenediamine to form a fluorescent product . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
156,
169
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
173,
193
]
} |
our results show that it is possible to deglycosylate proteins on nitrocellulose blots and then to examine their antigenicity and lectin-binding properties . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
54,
62
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
130,
136
]
} |
to dissociate the effects of dietary sodium from those of circulating angiotensin ii levels on glomerular receptor regulation , a fifth group was placed on high sodium diet and given a continuous infusion of angiotensin via an implanted minipump ( 100 ng/min ) for 21 d . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
70,
84
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
208,
219
]
} |
the infusion of angiotensin ii ( 100 mg/min ) for 15 min or 2 h into anesthetized rats maintained on moderate sodium intake resulted in a 50 % reduction in specific angiotensin binding that could not be reversed by the dissociation of endogenous angiotensin . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
16,
30
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
246,
257
]
} |
the adenosine analogue n6-phenylisopropyladenosine more effectively inhibited lipolysis in the older group ( 77 +/- 6 % ) than in the younger group ( 46 +/- 5 % ) , suggesting that enhanced efficacy of endogenous adenosine may account for the reduced lipolytic response to catecholamines . | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
26,
50
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
213,
222
]
} |
our data indicate that antigenic charge is an important determinant of antigen handling by the joint and , in addition , support the concept that the development of chronic arthritis depends on the amount of antigen retained in the joint . | NA | {
"id": "C0003316",
"name": "determinant",
"pos": [
56,
67
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
208,
215
]
} |
the influence of the duration of the exposure time ( 0.3-114 h ) and of the distribution of radioactivity between free and esterified cholesterol in plasma on the amount of radioactivity found in the arterial wall was studied by the simultaneous use of 3h- and 14c-cholesterol . | NA | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
123,
145
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
265,
276
]
} |
our data thus suggest that removal of esterified cholesterol from aortic tissue without visible atherosclerosis represents a major importance for the cholesterol concentration in the tissue . | NA | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
38,
60
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
150,
161
]
} |
corticotropin-like intermediate lobe peptide ( clip = acth18-39 ) , a naturally occurring derivative of pomc , has been suggested to be an insulin secretagogue . | NA | {
"id": "C0056374",
"name": "corticotropin-like intermediate lobe peptide",
"pos": [
0,
44
]
} | {
"id": "C0033195",
"name": "pomc",
"pos": [
104,
108
]
} |
histiocytic reticulum cells have been counted in 160 lymph nodes , comprising 50 high grade non-hodgkin 's lymphomas , 90 lymphomas of low grade histology , and 20 specimens exhibiting reactive follicular hyperplasia . | NA | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
92,
106
]
} | {
"id": "C0079747",
"name": "lymphomas",
"pos": [
122,
131
]
} |
retrograde transport of lectin-conjugated horseradish peroxidase ( wga-hrp ) or the fluorescent dye fast blue ( fb ) , injected into the ion , was used to localize regions in the midbrain and caudal diencephalon containing neurons which project to the inferior olive . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
42,
64
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
67,
74
]
} |
efficiency of conversion of feed protein to milk protein declined , but digestibility of dry matter , organic matter , and nitrogen was improved with increasing dietary protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
33,
40
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
161,
176
]
} |
efficiency of conversion of feed protein to milk protein declined , but digestibility of dry matter , organic matter , and nitrogen was improved with increasing dietary protein . | NA | {
"id": "C0026138",
"name": "milk protein",
"pos": [
44,
56
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
161,
176
]
} |
recovery of a water-soluble marker , included in drinking water offered after water was withheld for 4.5 or 9 h following feeding , was used to estimate ruminal bypass . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
49,
63
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
78,
83
]
} |
various sucrose derivatives and a sucrose analogue were enzymatically synthesized on the assumption that structural similarities of the sugars to sucrose would endow them with an ability to inhibit the cariogenicity of sucrose . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
136,
142
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
219,
226
]
} |
the effect of these sugars on sucrose-dependent synthesis and adherence of insoluble glucan and on acid fermentation of sucrose by streptococcus mutans was examined in vitro . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
20,
26
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
120,
127
]
} |
one hundred patients with drug-refractory recurrent sustained ventricular tachycardia associated with coronary artery disease who underwent mapping-directed subendocardial resection for ventricular tachycardia were retrospectively evaluated with respect to a number of morphologically distinct tachycardias on a 12 lead ... | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
62,
85
]
} | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
294,
306
]
} |
on the basis of mapping data , multiple configurations of ventricular tachycardia appear to originate in the same or adjacent sites in the majority of patients , although in 16 % of patients with multiple tachycardias , the tachycardias originate at widely separated sites . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
58,
81
]
} | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
224,
236
]
} |
in all six dogs pretreated with the peripheral dopaminergic antagonist domperidone ( group 3 ) , bromocriptine , 50 micrograms/kg , slowed ventricular tachycardia and in three of the six , tachycardia terminated . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
139,
162
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
189,
200
]
} |
the fall in antibody concentration ( in percent ) and elevations during exacerbation appeared to be similar for these antibody classes and are related with the number of precipitates measured by double immunodiffusion . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
12,
20
]
} | {
"id": "C0021017",
"name": "antibody classes",
"pos": [
118,
134
]
} |
rast inhibition of binding to anhydride-hsa substrates was done with various concentrations of sodium salts , lysine , and hsa conjugates of pa , hhpa , ha , and trimellitic anhydride ( tma ) in order to characterize cross-reactivity and specificity of humoral responses in these workers . | NA | {
"id": "C0003030",
"name": "anhydride",
"pos": [
30,
39
]
} | {
"id": "C0031783",
"name": "pa",
"pos": [
148,
150
]
} |
measurement of protein concentrations ( albumin , igg , iga , and igm ) by laser nephelometry and crossed immunoelectrophoresis indicates that transudation of proteins occurs from the circulation into the lung compartment during the acute stage of abpa . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
40,
47
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
159,
167
]
} |
those data , coupled with the tendency toward greater weight , suggested a greater incidence of overweight among kansas children than among elementary school children nationally . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
54,
60
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
96,
106
]
} |
levels of seven heavy metal residues , arsenic , cadmium , chromium , copper , lead , mercury and zinc were monitored in samples of the american oyster ( crassostrea virginica ) , the soft shell clam ( mya arenaria ) , the hard shell clam ( mercinaria mercinaria ) and the blue crab ( callinectes sapidus ) . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
16,
27
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
49,
56
]
} |
levels of seven heavy metal residues , arsenic , cadmium , chromium , copper , lead , mercury and zinc were monitored in samples of the american oyster ( crassostrea virginica ) , the soft shell clam ( mya arenaria ) , the hard shell clam ( mercinaria mercinaria ) and the blue crab ( callinectes sapidus ) . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
16,
27
]
} | {
"id": "C0008574",
"name": "chromium",
"pos": [
59,
67
]
} |
levels of seven heavy metal residues , arsenic , cadmium , chromium , copper , lead , mercury and zinc were monitored in samples of the american oyster ( crassostrea virginica ) , the soft shell clam ( mya arenaria ) , the hard shell clam ( mercinaria mercinaria ) and the blue crab ( callinectes sapidus ) . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
16,
27
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
70,
76
]
} |
levels of seven heavy metal residues , arsenic , cadmium , chromium , copper , lead , mercury and zinc were monitored in samples of the american oyster ( crassostrea virginica ) , the soft shell clam ( mya arenaria ) , the hard shell clam ( mercinaria mercinaria ) and the blue crab ( callinectes sapidus ) . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
16,
27
]
} | {
"id": "C0023175",
"name": "lead",
"pos": [
79,
83
]
} |
levels of seven heavy metal residues , arsenic , cadmium , chromium , copper , lead , mercury and zinc were monitored in samples of the american oyster ( crassostrea virginica ) , the soft shell clam ( mya arenaria ) , the hard shell clam ( mercinaria mercinaria ) and the blue crab ( callinectes sapidus ) . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
16,
27
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
86,
93
]
} |
levels of seven heavy metal residues , arsenic , cadmium , chromium , copper , lead , mercury and zinc were monitored in samples of the american oyster ( crassostrea virginica ) , the soft shell clam ( mya arenaria ) , the hard shell clam ( mercinaria mercinaria ) and the blue crab ( callinectes sapidus ) . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
16,
27
]
} | {
"id": "C0043481",
"name": "zinc",
"pos": [
98,
102
]
} |
nocturnal and daytime recumbent secretory patterns of norepinephrine , epinephrine and dopamine were determined at 30 min intervals in 9 normotensive males . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
54,
68
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
71,
82
]
} |
plasma levels of dopamine as well as those of norepinephrine and epinephrine followed a circadian pattern in these recumbent males . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
46,
60
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
65,
76
]
} |
as for norepinephrine and epinephrine , the sleep period in all 9 males was characterized by a paucity of dopamine secretory peaks as well as lower mean dopamine levels than during the awake state . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
7,
21
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
26,
37
]
} |
there was a strong relationship between the circadian changes in plasma dopamine levels and those of norepinephrine ( r = 0.92 ) and epinephrine ( r = 0.78 ) throughout the 24-h period of recumbency . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
101,
115
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
133,
144
]
} |
fifteen euthyroid volunteers were studied , 5 men and 10 women , with a mean age of 64.2 yr , who suffered from various cardiac arrhythmias ( atrial fibrillation or multiple ventricular extrasystoles ) . | NA | {
"id": "C0003811",
"name": "cardiac arrhythmias",
"pos": [
120,
139
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
142,
161
]
} |
antibodies specific to the isoantigens a and b were purified from human antisera by affinity chromatography using an immunoabsorbent containing chemically synthesized antigenic determinants . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
72,
80
]
} |
human muscle sections were examined for the presence of carbonic anhydrase using fluorescent second antibody and antisera specific for the three isozymes , carbonic anhydrase i ( cai ) , carbonic anhydrase ii ( caii ) , and carbonic anhydrase ( caiii ) . | NA | {
"id": "C0007033",
"name": "carbonic anhydrase i",
"pos": [
156,
176
]
} | {
"id": "C0007028",
"name": "carbonic anhydrase",
"pos": [
224,
242
]
} |
human muscle sections were examined for the presence of carbonic anhydrase using fluorescent second antibody and antisera specific for the three isozymes , carbonic anhydrase i ( cai ) , carbonic anhydrase ii ( caii ) , and carbonic anhydrase ( caiii ) . | NA | {
"id": "C0007034",
"name": "carbonic anhydrase ii",
"pos": [
187,
208
]
} | {
"id": "C0007028",
"name": "carbonic anhydrase",
"pos": [
224,
242
]
} |
the denatured catalytic polypeptide of mouse brain ( na+ + k+ ) -adenosine triphosphatase ( atpase ) was separated from microsomal membranes on polyacrylamide gels and used as an immunogen . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
6,
8
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
92,
98
]
} |
the present contribution deals with histochemical mapping of acetylcholinesterase , butyrylcholinesterase and non-specific esterase in the rhombencephalon and mesencephalon of the turtle ( l. punctata ) . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
61,
81
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
84,
105
]
} |
arginine has been shown to be essential for the replication of several orthopoxviruses in mouse sarcoma 180 cells and in chick embryo fibroblast cultures . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
108,
113
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
134,
144
]
} |
rosetted cells were subjected to very slow ( 100 x g ) density gradient centrifugation to isolate t rosettes ( and deplete pbmc of b cells ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
9,
14
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
123,
127
]
} |
mean values for plasmacytoid cells per 1000 cells recovered were as follows : t cells 168.16 +/- 96.7 sd , b cells 226.67 +/- 161.1 , pbmc 225.67 +/- 78.9 . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
29,
34
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
134,
138
]
} |
gating on log 90 degrees light scatter and log red fluorescence in this fashion reduced the incidence of nonspecific binding to peripheral blood mononuclear cells of a fluorescein-conjugated irrelevant monoclonal antibody by 98 % from 308 cells per million to 5 cells per million . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
128,
162
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
262,
267
]
} |
the normal range of calla-positive cells in adults is less than 16 cells per million peripheral blood mononuclear cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
35,
40
]
} | {
"id": "C1321301",
"name": "peripheral",
"pos": [
85,
95
]
} |
each mcab reacts poorly with formalin-fixed staphylococcus aureus or s. aureus protein a , which requires that an additional incubation with second antibody ( goat anti-rat immunoglobulin g ) is included in each radioimmunoassay paradigm . | NA | {
"id": "C0003250",
"name": "mcab",
"pos": [
5,
9
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
148,
156
]
} |
igg , iga and igm antibodies were determined in the sera of patients with pemphigus , pemphigoid , dermatitis herpetiformis , several autoimmune diseases , in a patient with massive cutaneous hyalinosis , in coeliac disease , and in control subjects . | NA | {
"id": "C0030807",
"name": "pemphigus",
"pos": [
74,
83
]
} | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
134,
153
]
} |
igg , iga and igm antibodies were determined in the sera of patients with pemphigus , pemphigoid , dermatitis herpetiformis , several autoimmune diseases , in a patient with massive cutaneous hyalinosis , in coeliac disease , and in control subjects . | NA | {
"id": "C0030805",
"name": "pemphigoid",
"pos": [
86,
96
]
} | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
134,
153
]
} |
igg , iga and igm antibodies were determined in the sera of patients with pemphigus , pemphigoid , dermatitis herpetiformis , several autoimmune diseases , in a patient with massive cutaneous hyalinosis , in coeliac disease , and in control subjects . | NA | {
"id": "C0011608",
"name": "dermatitis herpetiformis",
"pos": [
99,
123
]
} | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
134,
153
]
} |
one monoclonal antibody recognized a conformational determinant expressed only on native hcg molecule and another monoclonal antibody had the specificity for the epitopes located on the beta-subunit of hcg . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
89,
92
]
} | {
"id": "C0106132",
"name": "beta-subunit",
"pos": [
186,
198
]
} |
this assay was highly specific for hcg and there was no cross-reactivity with alpha , beta-subunit of hcg , luteinizing hormone and follicle stimulating hormone . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
35,
38
]
} | {
"id": "C0106132",
"name": "beta-subunit",
"pos": [
86,
98
]
} |
although pv antibodies have been localized on the epidermal cell surface by several techniques , little is known about the fate of these autoantibodies subsequent to their surface binding . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
12,
22
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
137,
151
]
} |
the following cells were cultured : normal skin fibroblasts ( f ) , normal ( k ) and sv 40 transformed ( svk14 ) keratinocytes , and a number of squamous carcinoma cell ( scc ) lines in which the defective terminal differentiation was found to occur in the following order of intensity : scc-12f2 less than scc-25 approx... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
14,
19
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
48,
59
]
} |
compared with normal human fibroblasts , most of the cells under study showed a defective response to changes of the extracellular serum ldl concentration . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
27,
38
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
53,
58
]
} |
the degree of inducibility of cholesterol synthesis after the cells were deprived of extracellular sources of cholesterol as well as the degree of the ldl-induced suppression of the intracellular cholesterol synthesis in cells preincubated in medium supplemented with lipoprotein-deficient serum decreased in the followi... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
30,
41
]
} | {
"id": "C0023824",
"name": "ldl",
"pos": [
151,
154
]
} |
the transformation of keratinocytes by sv 40 virus did not lead to any change in the response of the cells to changes in the extracellular ldl concentration since both the normal and the transformed keratinocytes showed the same response to ldl ( i.e. , no response ) . | NA | {
"id": "C0022567",
"name": "transformation",
"pos": [
4,
18
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
101,
106
]
} |
one hundred three young children were inoculated intranasally with either influenza a/california/10/78 cold-recombinant vaccine ( 10 ( 6.7 ) 50 % tissue culture infective doses [ tcid50 ] per child ) , cr-37 ( h1n1 ) , or influenza a/washington/897/80 cold-recombinant vaccine ( 10 ( 6.5 ) tcid50 per child ) , cr-48 ( h... | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
18,
32
]
} | {
"id": "C0008059",
"name": "child",
"pos": [
301,
306
]
} |
protein exudation and platelet deposition in lesions were measured with 125i-labeled albumin and 111in-labeled platelets . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
0,
7
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
85,
92
]
} |
natural beta interferon ( beta ifn ) , derived from diploid fibroblasts , has been evaluated for its antiproliferative activity using a panel of twelve different histologic types of fresh human tumor cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
60,
71
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
200,
205
]
} |
to study the changes in steroid concentrations in amniotic fluid ( af ) in relation to the initiation of parturition , eleven steroids in af which included cortisol ( f ) , progesterone ( p4 ) , 20 alpha-dihydroprogesterone , free ( f- ) and conjugated ( c- ) pregnenolone , dha , estradiol ( e2 ) and estriol ( e3 ) wer... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
173,
185
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
195,
223
]
} |
because circulating pla2 had been shown experimentally to cause profound systemic hypotension and degradation of pulmonary surfactant , this suggests a mechanistic relationship between the massive release of pla2 into the systemic circulation during the course of gram-negative septicemia , and the resultant hypotension... | NA | {
"id": "C0031667",
"name": "pla2",
"pos": [
20,
24
]
} | {
"id": "C0031672",
"name": "a",
"pos": [
379,
380
]
} |
the assay of plasma prekallikrein requires activation of prekallikrein to kallikrein and sufficient inactivation of the plasma protease inhibitors of kallikrein to accurately measure the generated kallikrein activity . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
20,
33
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
197,
207
]
} |
the addition of methylamine to plasma pretreated with chloroform in the plasma prekallikrein assay allowed for only a slight increase in the amount of kallikrein measured at 1 minute kaolin activation times , but provided for sustained measurement of activated prekallikrein when kaolin activation times were 5 to 7 minu... | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
82,
92
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
261,
274
]
} |
ventricular fibrillation ( vf ) and transient arrhythmias after defibrillation were analyzed from the recordings of 28 patients containing at least one episode of ventricular fibrillation . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
46,
57
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
163,
187
]
} |
the main transient arrhythmias generated by circulatory arrest during vf and by the defibrillation shock were : total arrest , total av-block and/or bradycardia . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
19,
30
]
} | {
"id": "C0042510",
"name": "vf",
"pos": [
70,
72
]
} |
comparison of episodes of vt and vf recorded in a single patient also shows that arrhythmias are more unfavourable and of longer duration after vf than after vt . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
81,
92
]
} | {
"id": "C0042510",
"name": "vf",
"pos": [
144,
146
]
} |
blockade of lh and fsh secretion by lh-releasing hormone , by the lh-releasing hormone analogue , buserelin , and by combined treatment with lh-releasing hormone and oestradiol benzoate . | NA | {
"id": "C0006456",
"name": "buserelin",
"pos": [
98,
107
]
} | {
"id": "C0023610",
"name": "lh-releasing hormone",
"pos": [
141,
161
]
} |
the lh and fsh release-stimulating ( experiment 1 ) and -blocking ( experiment 2 ) effects of lh-releasing hormone ( lhrh ) and of the lhrh analogue d-ser ( but ) 6-des-gly10-lhrh-ethylamide ( buserelin ) , as well as the effect of combined treatment with lhrh and oestradiol benzoate ( ob ; experiment 3 ) on the 'supra... | NA | {
"id": "C0006456",
"name": "buserelin",
"pos": [
193,
202
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
333,
337
]
} |
pretreatment with lhrh ( 250 or 500 ng/h ) or buserelin ( 250 ng/h ) for 6 days was effected by means of subcutaneously implanted alzet osmotic minipumps ; | NA | {
"id": "C0023610",
"name": "lhrh",
"pos": [
18,
22
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
46,
55
]
} |
experiment 1 revealed that after infusion of lhrh and buserelin , both at the rate of 1 microgram/h , plasma lhrh concentrations were established which were about twice as low as the plasma buserelin concentrations . | NA | {
"id": "C0023610",
"name": "lhrh",
"pos": [
45,
49
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
190,
199
]
} |
as an lh and fsh release-stimulating substance , however , it appeared that buserelin was about as effective as lhrh . | NA | {
"id": "C0006456",
"name": "buserelin",
"pos": [
76,
85
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
112,
116
]
} |
experiment 2 , however , suggested that as an lh/fsh release-blocking agent buserelin was much more effective than lhrh . | NA | {
"id": "C0006456",
"name": "buserelin",
"pos": [
76,
85
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
115,
119
]
} |
in addition , after buserelin pretreatment the pituitary glands contained much less lh and fsh than after lhrh pretreatment at both dose levels used . | NA | {
"id": "C0006456",
"name": "buserelin",
"pos": [
20,
29
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
106,
110
]
} |
the addition of 2 microm dihydrocytochalasin b ( or cytochalasin b ) together with aphidicolin during the second half of the inductive period inhibits the formation of supernumerary buds and upon removal of the cytochalasin rapid formation of buds takes place . | NA | {
"id": "C0010737",
"name": "cytochalasin b",
"pos": [
32,
46
]
} | {
"id": "C0010739",
"name": "cytochalasin",
"pos": [
211,
223
]
} |
85.5 % of the drivers whose bloods contained ethanol and 67.8 % of all drivers had becs greater than or equal to 1.0 g/l . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
45,
52
]
} | {
"id": "C0684262",
"name": "becs",
"pos": [
83,
87
]
} |
the two earliest human isolates , c/taylor/1233/47 and c/great lakes/1167/54 , had faster migrating np proteins , and another human strain , c/georgia/1/69 , displayed a faster migrating gp88 . | NA | {
"id": "C0028612",
"name": "np",
"pos": [
100,
102
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
103,
111
]
} |
antigenic sites present on these fragments may therefore represent essential constituents of a synthetic vaccine . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
0,
9
]
} | {
"id": "C0042213",
"name": "synthetic",
"pos": [
95,
104
]
} |
they show , furthermore , that not only is p21 present in some epithelial cells transformed by kimsv , but also that it is functionally active , as has been shown for fibroblasts transformed by the same virus , and that its functioning is maintained after passaging in vivo of the transformed cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
167,
178
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
293,
298
]
} |
when chick embryo fibroblasts infected with high multiplicities of a non-revertible temperature-sensitive ( ts ) mutant ( ts53 ) of newcastle disease virus ( ndv ) at the permissive temperature ( 34 degrees c ) and incubated to allow the appearance of virus-induced proteins were shifted up to and incubated at the non-p... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
18,
29
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
448,
456
]
} |
when chick embryo fibroblasts infected with high multiplicities of a non-revertible temperature-sensitive ( ts ) mutant ( ts53 ) of newcastle disease virus ( ndv ) at the permissive temperature ( 34 degrees c ) and incubated to allow the appearance of virus-induced proteins were shifted up to and incubated at the non-p... | NA | {
"id": "C0042736",
"name": "virus",
"pos": [
150,
155
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
397,
405
]
} |
residual nonspecific binding of iga in colostra appeared mainly due to antigen lipids or to lipoproteins . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
79,
85
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
92,
104
]
} |
enzymatic reduction of synthetic polymer-bound hemin derivatives : efficient method to prepare a heme-oxygen adduct in cooled aqueous medium . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
47,
52
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
97,
101
]
} |
eighteen patients with delayed traumatic intracerebral haematoma were selected as the study subjects from 268 consecutive patients with head trauma and compared with another two groups of patients with closed head injury ( 20 cases ) and with multiple injuries ( 24 cases ) . | NA | {
"id": "C0018674",
"name": "head trauma",
"pos": [
136,
147
]
} | {
"id": "C0085094",
"name": "closed head injury",
"pos": [
202,
220
]
} |
a major reason for the conflicting views concerning prognosis in epilepsy has been the failure to account for the temporal aspects of seizure relapse and remission . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
65,
73
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
134,
141
]
} |
the patterns of epilepsy are established relatively early in its course in most cases , and long term prognosis might therefore be predictable within a few years of the onset of seizures in most patients . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
16,
24
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
178,
186
]
} |
although the cell cultures appeared heterogeneous and sometimes included fibroblasts , most of the cells were glial and many were identified as astrocytes by their morphology and immunochemical label . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
73,
84
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
99,
104
]
} |
adenylate cyclase activity in bovine retina was stimulated approximately 50 % by guanosine 5'-triphosphate ( gtp ) , but the nonhydrolyzable gtp analogue , guanosine-5'- ( beta , gamma-imido ) triphosphate ( gpp ( nh ) p ) , was able to activate the enzyme nearly 5-fold . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
109,
112
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
208,
220
]
} |
the current study demonstrates that the ability of guanosine 5'-triphosphate ( gtp ) and its nonhydrolyzable analogue guanylyl-5'-imidodiphosphate ( gpp ( nh ) p ) to inhibit opiate agonist binding to rat brain membranes can be altered by two methods : by preincubating with edta , and by preincubating at ph 4.5 . | NA | {
"id": "C0018353",
"name": "guanosine",
"pos": [
51,
60
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
149,
161
]
} |
the alkaloid nicotinic agonists , cytisine and lobeline , were potent inhibitors of binding , while acetylcholine in the presence of the cholinesterase inhibitor di-isopropylfluorophosphate was equipotent with ( + ) -nicotine . | NA | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
4,
12
]
} | {
"id": "C0023929",
"name": "lobeline",
"pos": [
47,
55
]
} |
because iecps may serve as precursors to ops , these results suggest increased processing of op precursors following treatment with catecholamine-depleting drugs in addition to an increased rate of op precursor synthesis . | NA | {
"id": "C0014298",
"name": "iecps",
"pos": [
8,
13
]
} | {
"id": "C0205753",
"name": "op",
"pos": [
198,
200
]
} |
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