text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the forced random noise method for measuring respiratory resistance was studied in terms of reproducibility and correlation with spirometry and flow volumes in 30 older children ( four to 17 years ) with asthma and in 16 infants and children below three years of age . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
163,
177
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
233,
241
]
} |
in halothane-anaesthetized cats implanted with several push-pull cannulae the release of dopamine from nerve terminals and dendrites of the two nigrostriatal dopaminergic pathways is shown to be asymmetrically or symmetrically regulated bilaterally when dopaminergic or gabaergic drugs are infused into one side of the n... | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
89,
97
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
254,
266
]
} |
overnight studies did not reveal hypoglycemia ( blood glucose less than 2 mmol/l ) in either group , but improved overnight glucose profiles were demonstrated on the `` '' increased '' '' dosage and were associated with higher free insulin levels . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
48,
61
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
124,
131
]
} |
the metabolism and excretion of 2- , 3- , and 4-nitrotoluene ( 2nt , 3nt , and 4nt , respectively ) were studied in male fischer 344 rats . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
4,
14
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
19,
28
]
} |
the renal clearances of sulfisoxazole ( sx ) and n4-acetylsulfisoxazole ( nsx ) were studied in the isolated perfused rat kidney ( ipk ) . | NA | {
"id": "C0038745",
"name": "sulfisoxazole",
"pos": [
24,
37
]
} | {
"id": "C0081437",
"name": "acetylsulfisoxazole",
"pos": [
52,
71
]
} |
the results presented herein indicate that the disposition of sulfisoxazole by the ipk involves both metabolism and excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
101,
111
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
116,
125
]
} |
the absorption , metabolism , and excretion of 14c-labeled xamoterol ( ici 118,587 ) has been examined in mice , rats , rabbits , dogs , and humans . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
17,
27
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
34,
43
]
} |
the results indicate that the risk for the child from rubella vaccination of the mother before pregnancy and in the first trimester is minimal . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
95,
104
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
116,
131
]
} |
[ demonstration of igg- and iga-antibodies against epstein-barr virus-associated antigens with a microtiter enzyme immunoassay system . the determination of serum antibodies against the viral capsid antigen and the early antigen complex in the sera of tumor and infectious mononucleosis patients ] . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
81,
89
]
} | {
"id": "C0003342",
"name": "viral",
"pos": [
186,
191
]
} |
the levels of growth hormone , vasopressin , prolactin , calcitonin , gastrin , insulin , epinephrine , norepinephrine and dopamine were measured in six lactating women during breast feeding . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
90,
101
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
104,
118
]
} |
no differences were detected in the rate of phosphate anion transfer through the erythrocyte membranes in the examined persons . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
44,
53
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
54,
59
]
} |
the time relations of epileptic events have been studied in 3 sets of data : ( i ) counts of individual epileptiform discharges in twelve 48 h eeg recordings , ( iia ) seizure calendars of 30 therapy-resistant outpatients participating in a drug trial , ( iib ) seizure calendars of 10 mentally subnormal epileptic patie... | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
168,
175
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
305,
314
]
} |
the first part of this article presents the hypotheses of the mechanism of action of the anti-epileptic drug , valproic acid ( vpa ) . | NA | {
"id": "C3537002",
"name": "anti-epileptic drug",
"pos": [
89,
108
]
} | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
111,
124
]
} |
carbidopa treatment was not associated with changes in left ventricular filling pressure , arterial blood pressure , glomerular filtration rate , renal blood flow , renal excretion of norepinephrine or epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
184,
198
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
202,
213
]
} |
despite an overall 2-fold decrease in protein synthesis in cells treated with actd at 24 h , the synthesis of individual proteins maximally induced by tsh during the first 8 h is increased , whereas that of some proteins maximally synthesized after 24-30 h is markedly reduced . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
46,
55
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
212,
220
]
} |
the 320,000 mol wt protein constituted only a minute amount of total radiolabeled membrane protein , because it was not apparent on electrophoresis of the membrane extract before immunoprecipitation . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
19,
26
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
82,
98
]
} |
no specific immunoprecipitation of any protein was observed when radiolabeled guinea pig membrane proteins were used . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
39,
46
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
89,
106
]
} |
to facilitate analyses of the cellular processing of pre-proglucagon and to begin studies of the regulation of glucagon gene expression in the rat , we have cloned and sequenced two cdnas derived from rat neonatal pancreas . | NA | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
57,
68
]
} | {
"id": "C0017687",
"name": "glucagon",
"pos": [
111,
119
]
} |
the coding region of pre-proglucagon contains , in addition to the sequence of glucagon , the sequences of two peptide domains that are related in their structures to glucagon . | NA | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
25,
36
]
} | {
"id": "C0017687",
"name": "glucagon",
"pos": [
167,
175
]
} |
comparisons of the nucleotide sequence of the rat pre-proglucagon cdna with those of the two pre-proglucagons of the anglerfish pancreas encoded by two separate genes indicate that the pre-proglucagon genes probably evolved by intragenic duplications of a dna segment corresponding to the coding sequences of glucagon an... | NA | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
54,
65
]
} | {
"id": "C0017687",
"name": "glucagon",
"pos": [
326,
334
]
} |
comparisons of the nucleotide sequence of the rat pre-proglucagon cdna with those of the two pre-proglucagons of the anglerfish pancreas encoded by two separate genes indicate that the pre-proglucagon genes probably evolved by intragenic duplications of a dna segment corresponding to the coding sequences of glucagon an... | NA | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
54,
65
]
} | {
"id": "C0014361",
"name": "glucagon-like peptides",
"pos": [
326,
348
]
} |
the stimulatory effects of both hormones are dependent on hormone concentration , time , and the guanine nucleotide gtp . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
97,
115
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
116,
119
]
} |
in the present study , the igf , multiplication stimulating activity ( msa ) , at concentrations of 100-1000 ng/ml , stimulated 35so4 incorporation into proteoglycans by endothelial cells cultured from bovine pulmonary arteries . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
27,
30
]
} | {
"id": "C0021666",
"name": "msa",
"pos": [
71,
74
]
} |
somatomedin used for gag synthesis and displacement was the partially purified somatomedin a with a biological activity of 80 u/mg . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
0,
11
]
} | {
"id": "C0021666",
"name": "somatomedin a",
"pos": [
79,
92
]
} |
in order to elucidate the relationship between cyclic amp and the ca2+-calmodulin system in the steroidogenic response to adrenocorticotropic hormone ( acth ) , the effects of calmodulin inhibitors ( trifluoperazine and w-7 ) on cortisol production and cellular cholesterol ester hydrolysis induced by acth or dibutyryl ... | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
47,
57
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
310,
330
]
} |
reproductive endpoints included pup survival in utero ( percent of live litters/pregnant survivors ) , pup perinatal and postnatal survival ( number of live pups per litter , number of dead pups per litter , and pup survival to 2.5 days of age ) , and pup body weight statistics ( weight at birth and weight at 2.5 days ... | NA | {
"id": "C0005612",
"name": "weight",
"pos": [
261,
267
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
301,
307
]
} |
pretreatment with the aldehyde dehydrogenase inhibitors disulfiram or pargyline did not ameliorate the testicular toxicity of egme . | NA | {
"id": "C2917344",
"name": "aldehyde dehydrogenase inhibitors",
"pos": [
22,
55
]
} | {
"id": "C0012772",
"name": "disulfiram",
"pos": [
56,
66
]
} |
i-cell fibroblasts can accumulate cystine at levels comparable to those seen in homozygous cystinotic fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
2,
6
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
102,
113
]
} |
normal , cystinotic and i-cell fibroblasts were exposed to radioactive cystine dimethyl ester , and the clearance of the generated radioactive cystine was measured . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
26,
30
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
31,
42
]
} |
cystinotic cells showed a marked defect in cystine clearance in situ , as compared to normal fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
11,
16
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
93,
104
]
} |
in i-cell fibroblasts , we observed slow hydrolysis of cystine dimethyl ester to cystine , indicating low esterase activity , but no defect in clearance of the generated cystine . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
5,
9
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
10,
21
]
} |
cysteine production from the exogenous cystine dimethyl ester , presumably by cytoplasmic hydrolysis of the generated cystine , is normal in i-cell fibroblasts . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
131,
137
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
148,
159
]
} |
while monoclonal antibodies theoretically represent an excellent ( perhaps superior ) alternative to conventional antisera as diagnostic , therapeutic or laboratory reagents , traditional antisera may be preferable to monoclonal antibody in some circumstances because of the fixed affinity and specificity as well as the... | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
114,
122
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
359,
369
]
} |
while monoclonal antibodies theoretically represent an excellent ( perhaps superior ) alternative to conventional antisera as diagnostic , therapeutic or laboratory reagents , traditional antisera may be preferable to monoclonal antibody in some circumstances because of the fixed affinity and specificity as well as the... | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
218,
237
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
359,
369
]
} |
the half-life of this mrna was determined both from the decay kinetics , after a chase with actinomycin d , and from the labeling kinetics during an accumulation experiment . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
4,
13
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
130,
138
]
} |
the free enzyme and the enzyme-glucose complex exhibit , upon ph jumps , conformational transitions which may be followed by monitoring the fluorescence of enzyme-bound toluidinylnaphthalene sulfonate . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
9,
15
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
156,
162
]
} |
we conclude that in the perfused liver , anoxia and kcn stimulate glycogen breakdown and glucose output , at least in part , by a mechanism that does not involve conversion of phosphorylase b to phosphorylase a . | NA | {
"id": "C0031711",
"name": "phosphorylase b",
"pos": [
176,
191
]
} | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
195,
208
]
} |
these experiments indicate that liberation of the sporulation pigment ( s ) from the complexes with ribosomal proteins and assembly of de novo synthesized proteins and proteins from a preexisting pool in the spore are involved in the reactivation of the ribosomes of dormant spores of s. granaticolor . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
100,
118
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
168,
176
]
} |
two proteic inhibitors ( i and ii ) of serine proteases have been purified from the parasitic worm parascaris equorum by affinity chromatography on immobilized trypsin followed by preparative electrophoresis . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
39,
55
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
160,
167
]
} |
to elucidate the potential harmful effects of sodium nitroprusside ( np ) on myocardial ischaemia , eleven patients with coronary artery disease were studied before and during two doses np infusion . | NA | {
"id": "C0037533",
"name": "sodium nitroprusside",
"pos": [
46,
66
]
} | {
"id": "C0028193",
"name": "np",
"pos": [
186,
188
]
} |
unidirectional or temporary local block of conduction , a mechanism always involved in initiation of reciprocating rhythms but also of importance for the maintenance of the arrhythmia . | NA | {
"id": "C0018794",
"name": "block",
"pos": [
34,
39
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
173,
183
]
} |
examples of such arrhythmias are reciprocating sinus tachycardia ( rst ) , reciprocating atrial tachycardia ( rat ) , reciprocating junctional tachycardia ( rjt ) , reciprocating atrioventricular tachycardia in connection with accessory pathways and ventricular tachycardia in the chronic stages of myocardial infarction... | NA | {
"id": "C0242514",
"name": "reciprocating",
"pos": [
33,
46
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
262,
273
]
} |
one cr and three pr have been seen out of 13 malignant lymphomas ( four hodgkin 's disease and nine non-hodgkin 's lymphomas ) . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
45,
64
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
72,
90
]
} |
one cr and three pr have been seen out of 13 malignant lymphomas ( four hodgkin 's disease and nine non-hodgkin 's lymphomas ) . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
45,
64
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
100,
124
]
} |
the overall population of early passaged cells consisted of a mixture of predominantly epithelial-like cells and few fibroblast-like cells ; | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
117,
127
]
} |
this is the first report of the use of dhm 32-550 a dehydrogenated peptide ergot alkaloid with both alpha and beta adrenoceptor blocking activity , in patients with angina-like chest pain . | NA | {
"id": "C0008031",
"name": "in",
"pos": [
133,
135
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
165,
171
]
} |
two rat igg2b monoclonal antibodies bound to different epitopes on a offgle rt1aa antigen molecule synergize in their induction of complement-mediated lysis of the red cells . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
55,
63
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
82,
89
]
} |
when one of the antibodies was used alone , the number of c1q molecules bound relative to the amount of antibody was higher than expected from theoretical considerations based on a presumed random distribution of antigen-antibody complex . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
104,
112
]
} | {
"id": "C0003313",
"name": "antigen-antibody complex",
"pos": [
213,
237
]
} |
highly purified samples of granulocyte/macrophage colony-stimulating factor , colony-stimulating factor 1 and multilineage-hematopoietic growth factor are effective in this assay suggesting that the colony-stimulating factors are the active components under these conditions . | NA | {
"id": "C0079784",
"name": "colony-stimulating factor 1",
"pos": [
78,
105
]
} | {
"id": "C0009392",
"name": "colony-stimulating factors",
"pos": [
199,
225
]
} |
highly purified samples of granulocyte/macrophage colony-stimulating factor , colony-stimulating factor 1 and multilineage-hematopoietic growth factor are effective in this assay suggesting that the colony-stimulating factors are the active components under these conditions . | NA | {
"id": "C0021757",
"name": "hematopoietic growth factor",
"pos": [
123,
150
]
} | {
"id": "C0009392",
"name": "colony-stimulating factors",
"pos": [
199,
225
]
} |
the localization of the three best-defined thymic hormones , namely , thymulin , thymopoietin and thymosin alpha 1 was studied by immunofluorescence using antibodies directed against these three molecules . | NA | {
"id": "C0040114",
"name": "thymic hormones",
"pos": [
43,
58
]
} | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
81,
93
]
} |
the double-labeling experiments using the different anti-thymic hormone antibodies showed that the same epithelial cells contained the three hormones . | NA | {
"id": "C0040114",
"name": "thymic hormone",
"pos": [
57,
71
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
141,
149
]
} |
in the mouse vas deferens preparation , naltrexone and naloxone were equipotent in antagonizing both morphine and [ d-ala2-d-leu5 ] enkephalin . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
40,
50
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
55,
63
]
} |
these findings also point out the uniqueness of the mu receptor system in the guinea pig ileum which is reflected by the potency differences between naltrexone and naloxone . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
149,
159
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
164,
172
]
} |
bladder activity was consistently inhibited by the mu-agonists morphiceptin and [ d-ala2 , mephe4 , gly- ( ol ) 5 ] enkephalin ( dago ) and by [ d-ala2 , d-leu5 ] enkephalin ( dadle , delta-agonist ) . | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
129,
133
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
163,
173
]
} |
the sulfonylurea glyburide , a 'second-generation ' oral hypoglycemic compound , was studied in vitro in order to determine its cellular mechanism of action in adipocytes prepared from cultured rat epididymal fat tissue . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
4,
16
]
} | {
"id": "C0017628",
"name": "glyburide",
"pos": [
17,
26
]
} |
effect of cyclic amp on cellular contractility and dna synthesis in chorioretinal fibroblasts maintained in collagen matrices . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
24,
32
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
82,
93
]
} |
complementary adhesive responses of human skin fibroblasts to the cell-binding domain of fibronectin and the heparan sulfate-binding protein , platelet factor-4 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
47,
58
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
66,
70
]
} |
plasma fibronectin ( pfn ) contains binding domains for an unidentified receptor on the surface of fibroblasts and for heparan sulfate chains of proteoglycans on these same cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
99,
110
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
173,
178
]
} |
density-dependent regulation of growth in somatic hybrids between normal chinese hamster fibroblasts and v79-8 ( g1- ) cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
89,
100
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
119,
124
]
} |
somatic hybrids were obtained between normal fibroblasts from newborn chinese hamsters , which show a strong response to ddr , and v79-8 chinese hamster cells , which are insensitive to ddr . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
45,
56
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
153,
158
]
} |
our results may mean that the g1- property provided by v79-8 is unable to overcome the very long g1 of normal fibroblasts , or in cells that can be arrested in g1 in response to ddr , some function prevents the dominant effect of the g1- cell on at least part of the g1 period . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
110,
121
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
263,
266
]
} |
correcting the colony number for this , we obtained a cell mixture consisting of 88 % psc , contaminated with 4 % committed precursor cells and about 10 % ganuloid cells . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
124,
139
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
164,
169
]
} |
significant concentrations of norepinephrine ( mean = 4.4 nmol l-1 ) and epinephrine ( mean = 3.7 nmol l-1 ) were detected in some of the subjects . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
30,
44
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
73,
84
]
} |
a 130 000 molecular weight peptide ( gpii ) specifically bound con a , wga , dolichos biflorus agglutinin , ( dba ) ulex europaeus agglutinin ( uea ) and pa , whereas the major 142 000 d protein ( gpi ) of the photoreceptor membrane bound only con a and wga implying a rather simple hexose chain consisting mainly of man... | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
283,
289
]
} | {
"id": "C0024742",
"name": "mannose",
"pos": [
317,
324
]
} |
while other in vitro synthesized lens proteins under these conditions migrate as theoretically expected , gamma-crystallin is retarded , having a mobility comparable to a 92 000 dalton component . | NA | {
"id": "C0010422",
"name": "lens proteins",
"pos": [
33,
46
]
} | {
"id": "C0017030",
"name": "gamma-crystallin",
"pos": [
106,
122
]
} |
since other in vitro synthesized lens proteins have molecular weights of approximately 20 000 daltons , it is only with this methodology that gamma-crystallin synthesis can be unequivocally followed in a simple , rapid , one-dimensional fractionation system . | NA | {
"id": "C0010422",
"name": "lens proteins",
"pos": [
33,
46
]
} | {
"id": "C0017030",
"name": "gamma-crystallin",
"pos": [
142,
158
]
} |
a 2 hr treatment of the rat lens with 1 mm cdnb resulted in a nearly total depletion of lens gsh with neither formation of gssg nor glutathione-protein mixed disulfides . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
123,
127
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
132,
143
]
} |
electrically elicited seizures from the inferior colliculus : a potential site for the genesis of epilepsy ? | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
22,
30
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
98,
106
]
} |
in vitro e-s product contained less negatively charged glycosaminoglycan than either heparin or chondroitin sulfate , and proteins of various molecular weights . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
55,
72
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
85,
92
]
} |
several tetracyclines ( minocycline , doxycycline , tetracycline ) , in levels approximating physiologic concentrations , were found to inhibit parathyroid hormone-induced bone resorption in organ culture ; | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
8,
21
]
} | {
"id": "C0026187",
"name": "minocycline",
"pos": [
24,
35
]
} |
several tetracyclines ( minocycline , doxycycline , tetracycline ) , in levels approximating physiologic concentrations , were found to inhibit parathyroid hormone-induced bone resorption in organ culture ; | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
8,
21
]
} | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
38,
49
]
} |
in doses of 6-23 mg/kg , the compounds under study prevented the development of the mixed type arrhythmia induced by intravenous injection of aconitine , prolonged the time of survival and prevented the animals ' death during intravenous injection of the arrhythmogenic doses of strophanthine , prolonged the refractory ... | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
95,
105
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
360,
384
]
} |
treatment of rats or liver homogenates with catecholamines ( isoproterenol or noradrenaline ) increased activities of both nad+ -dependent isocitrate dehydrogenase and nad ( p ) +-transhydrogenase ( in the direction of hydrogen transfer nadph -- -- nad+ ) with no change in nadp+ -dependent isocitrate dehydrogenase . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
44,
58
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
61,
74
]
} |
based on the assumption that pp60c-src might play a role in the control of cell proliferation , we have studied its behaviour as a substrate for phosphorylation known to occur when quiescent , serum-deprived cells are stimulated to enter cell cycle following addition of either serum , platelet-derived growth factor or ... | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
324,
337
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
351,
388
]
} |
when hl-60 cells were induced to differentiate into macrophages by 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) , cell-associated pa activity and secretion of pa into the conditioned medium increased profoundly . | NA | {
"id": "C0032143",
"name": "tpa",
"pos": [
107,
110
]
} | {
"id": "C0032144",
"name": "pa",
"pos": [
160,
162
]
} |
the small nuclear rnp ( alpha-rnp ) tightly bound to chromatin has been isolated . alpha-rnp can be removed from chromatin together with the acid-soluble proteins . | NA | {
"id": "C0142661",
"name": "small nuclear rnp",
"pos": [
4,
21
]
} | {
"id": "C0035544",
"name": "rnp",
"pos": [
89,
92
]
} |
assembly of these subunits was not observed in mitochondria incubated in the presence of heme b ( hemin ) or in the absence of heme . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
98,
103
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
127,
131
]
} |
adenosine and its 'ri'- and ' p'-site analogs , n6-phenylisopropyladenosine and 2'-deoxyadenosine , stimulate , like insulin , lipoprotein lipase ( lpl ) activity in adipose tissue , an effect which is suppressed by cycloheximide . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
51,
75
]
} |
phosphorylation of histones and non-histone nuclear proteins in liver cells stimulated by glucagon and cyclic amp . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
19,
26
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
44,
60
]
} |
the xanes ( x-ray absorption near edge structure ) spectra of deoxy human adult haemoglobin ( hba ) and myoglobin ( mb ) have been measured at the wiggler beam line of the frascati synchrotron radiation facility . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
80,
91
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
94,
97
]
} |
ascorbate reduces superoxide to peroxide , as indicated by measurements of the stoichiometry of ascorbate and oxygen consumption . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
18,
28
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
32,
40
]
} |
two human glucagon-like peptides , glp-1 and glp-2 , which are coencoded with pancreatic glucagon in the preproglucagon gene , do not significantly inhibit [ 125i ] monoiodoglucagon binding to rat liver and brain membranes and do not activate adenylate cyclase in liver plasma membranes . | NA | {
"id": "C0014361",
"name": "glucagon-like peptides",
"pos": [
10,
32
]
} | {
"id": "C0061355",
"name": "glp-1",
"pos": [
35,
40
]
} |
two human glucagon-like peptides , glp-1 and glp-2 , which are coencoded with pancreatic glucagon in the preproglucagon gene , do not significantly inhibit [ 125i ] monoiodoglucagon binding to rat liver and brain membranes and do not activate adenylate cyclase in liver plasma membranes . | NA | {
"id": "C0014361",
"name": "glucagon-like peptides",
"pos": [
10,
32
]
} | {
"id": "C0912332",
"name": "glp-2",
"pos": [
45,
50
]
} |
immunoneutralization of maternal rcp results in a greater than 90 % decrease in the content and the incorporation of [ 2-14c ] riboflavin into embryonic fad as well as a percentage redistribution of both embryonic fmn and riboflavin . | NA | {
"id": "C0016388",
"name": "fmn",
"pos": [
214,
217
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
222,
232
]
} |
the results all support a model of aars complex function wherein the high-molecular-weight complexes form aminoacyl-trna by utilizing extracellular amino acids immediately on their transport and before they have equilibrated with the internal pool . | NA | {
"id": "C0035714",
"name": "aminoacyl-trna",
"pos": [
106,
120
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
148,
159
]
} |
kinase ii was found , on the one hand , to phosphorylate tyrosine 3-monooxygenase and tryptophan 5-monooxygenase , leading to the activation of these monooxygenases in the presence of activator protein and , on the other hand , to phosphorylate tubulin and microtubule-associated protein 2 , which results in disassembly... | NA | {
"id": "C0041491",
"name": "tyrosine 3-monooxygenase",
"pos": [
57,
81
]
} | {
"id": "C0020364",
"name": "monooxygenases",
"pos": [
150,
164
]
} |
kinase ii was found , on the one hand , to phosphorylate tyrosine 3-monooxygenase and tryptophan 5-monooxygenase , leading to the activation of these monooxygenases in the presence of activator protein and , on the other hand , to phosphorylate tubulin and microtubule-associated protein 2 , which results in disassembly... | NA | {
"id": "C0041252",
"name": "tryptophan 5-monooxygenase",
"pos": [
86,
112
]
} | {
"id": "C0020364",
"name": "monooxygenases",
"pos": [
150,
164
]
} |
this study investigates the prevalence of chlamydia trachomatis antibodies in 164 infertile women who underwent diagnostic laparoscopy and dye insufflation as part of routine infertility investigations . | NA | {
"id": "C0021361",
"name": "infertile women",
"pos": [
82,
97
]
} | {
"id": "C0021359",
"name": "infertility",
"pos": [
175,
186
]
} |
these data demonstrate that the ectopic endometrium in infertile women with endometriosis does not secrete prl in amounts sufficient to elevate pf concentrations and suggest that the infertility observed in these women is probably not dependent upon the secretory activity of endometriotic implants . | NA | {
"id": "C0021361",
"name": "infertile women",
"pos": [
55,
70
]
} | {
"id": "C0021359",
"name": "infertility",
"pos": [
183,
194
]
} |
in absence of the bivalent cations in the extracellular space the ca channels loose their selectivity and allow monovalent cations to pass , the reason for this transformation beeing a disruption between the bound ca ions and the specific regulating compound within the ca channels . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
27,
34
]
} | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
112,
130
]
} |
in absence of the bivalent cations in the extracellular space the ca channels loose their selectivity and allow monovalent cations to pass , the reason for this transformation beeing a disruption between the bound ca ions and the specific regulating compound within the ca channels . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
27,
34
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
217,
221
]
} |
restriction of motor activity and motor-alimentary conditioning in dogs reduced the adrenaline ( a ) and noradrenaline ( na ) contents in the myocardium , dopamine , too , revealing a tendency to reduction . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
84,
94
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
105,
118
]
} |
in the present study , the effects of o , p'-ddd on plasma levels of pregnenolone , 17 alpha-hydroxypregnenolone , progesterone , 17 alpha-hydroxyprogesterone , 11-deoxycorticosterone , deoxycortisol , corticosterone , cortisol , androstenedione and testosterone were studied in 6 patients with adrenal carcinoma ( 3 wit... | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
69,
81
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
84,
112
]
} |
in the present study , the effects of o , p'-ddd on plasma levels of pregnenolone , 17 alpha-hydroxypregnenolone , progesterone , 17 alpha-hydroxyprogesterone , 11-deoxycorticosterone , deoxycortisol , corticosterone , cortisol , androstenedione and testosterone were studied in 6 patients with adrenal carcinoma ( 3 wit... | NA | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
322,
341
]
} | {
"id": "C0001622",
"name": "cushing 's disease",
"pos": [
424,
442
]
} |
the decrement of progesterone and 17 alpha-hydroxyprogesterone was greater than that of pregnenolone and 17 alpha-hydroxypregnenolone . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
88,
100
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
105,
133
]
} |
plasma levels of pregnenolone and 17 alpha-hydroxypregnenolone showed a twofold increase on the 7th day after consecutive administrations of o , p'-ddd in patients with cushing 's disease . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
17,
29
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
34,
62
]
} |
significantly elevated values of ig g class apa ( ig g-apa ) were detected in the sera from patients with graves ' or hashimoto 's disease . | NA | {
"id": "C0021017",
"name": "ig g class",
"pos": [
33,
43
]
} | {
"id": "C0020852",
"name": "ig g",
"pos": [
33,
37
]
} |
a 42-year-old man had suffered from skin psoriasis for 27 years , psoriasis arthritis for 6 years and corneal crystalline deposits for 1 year , when an igg-kappa monoclonal immunoglobulin was detected in his serum electrophoretic pattern . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
41,
50
]
} | {
"id": "C0003872",
"name": "psoriasis",
"pos": [
66,
75
]
} |
2 young patients with schonlein-henoch purpura were investigated to detect secretory iga and secretory component ( sc ) in skin lesions and urine in connection with the upper respiratory and intestinal symptoms at onset . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
75,
88
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
93,
112
]
} |
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