text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
however , microsomal acyl-coa:1-acylglycerol 3-phosphate acyltransferase ( 1-acyl-gpat ) activity increased ( 24-33 per cent , p less than 0.01 ) in the diabetic animals using 3 different acyl-coa donors : palmitoyl-coa , oleoyl-coa and linoleoyl-coa . | NA | {
"id": "C0001374",
"name": "acyl-coa",
"pos": [
21,
29
]
} | {
"id": "C0030239",
"name": "palmitoyl-coa",
"pos": [
206,
219
]
} |
gamma linolenic and docosotetraenoic hydroperoxides were reduced rapidly , whereas the peroxides of docosohexaenoic and 11,14 eicosodienoic were reduced at the lowest rate . | NA | {
"id": "C0020281",
"name": "hydroperoxides",
"pos": [
37,
51
]
} | {
"id": "C0031180",
"name": "peroxides",
"pos": [
87,
96
]
} |
it is concluded that the short chain fatty acids are incorporated into the milk triacylglycerols during the final stage of biosynthesis via the phosphatidic acid pathway , and that the overall fatty acid distribution is consistent with the 1-random 2-random 3-random hypothesis . | NA | {
"id": "C0015691",
"name": "short chain",
"pos": [
25,
36
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
193,
203
]
} |
the results showed a marked asymmetry in the distribution of the fatty acids in all samples , with the saturated acids predominantly in the sn-1-position and the unsaturated fatty acids distributed about equally between the sn-2- and sn-3-positions . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
65,
76
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
162,
185
]
} |
in 20 patients with non-malignant diffuse liver disease ( cirrhosis or fatty liver ) and 33 with malignant liver disease , initial volumes ranged from 1000 to 4900 ml and did not correlate with body weight . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
42,
55
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
58,
67
]
} |
in 20 patients with non-malignant diffuse liver disease ( cirrhosis or fatty liver ) and 33 with malignant liver disease , initial volumes ranged from 1000 to 4900 ml and did not correlate with body weight . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
42,
55
]
} | {
"id": "C0015695",
"name": "fatty liver",
"pos": [
71,
82
]
} |
the paper is concerned with the results of a study of the aldosterone concentration and renin activity , the general level of catecholamines and their fractions ( epinephrine , norepinephrine and dopamine ) in the peripheral blood and blood taken at selective venography from the vena cava inferior , renal and adrenal v... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
163,
174
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
177,
191
]
} |
recognition of ah is not usually difficult , but does require a high index of suspicion , since many disease processes may give rise to hemoptysis with infiltrates on chest roentgenogram . | NA | {
"id": "C0019080",
"name": "ah",
"pos": [
15,
17
]
} | {
"id": "C0019079",
"name": "hemoptysis",
"pos": [
136,
146
]
} |
in 36 workers occupationally exposed to polychlorinated pesticides ( gammexane , ddt ) and in a control group , cytochemical investigations of lactate and succinate dehydrogenases ( ldh and sdh , respectively ) in peripheral blood leukocytes were performed . | NA | {
"id": "C0038615",
"name": "succinate dehydrogenases",
"pos": [
155,
179
]
} | {
"id": "C0283592",
"name": "sdh",
"pos": [
190,
193
]
} |
the binding and action of insulin and of the insulin-like growth factor , multiplication-stimulating activity ( msa ) , were studied in cultured skin fibroblasts from an infant with leprechaunism and associated insulin resistance . | NA | {
"id": "C0037657",
"name": "insulin-like growth factor",
"pos": [
45,
71
]
} | {
"id": "C0021666",
"name": "multiplication-stimulating activity",
"pos": [
74,
109
]
} |
three actions of insulin were reduced in the leprechaun cells : activation of glycogen synthase was 30 % as great as in control fibroblasts , the increase in 2-deoxyglucose transport was 33 % of the control value , and the uptake of alpha-aminoisobutyric acid was sevenfold less sensitive to enhancement . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
56,
61
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
128,
139
]
} |
to localize the site of insulin resistance , the binding of both [ 125i ] -insulin and [ 125i ] -msa to fibroblasts was measured and found to be reduced in the leprechaun cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
104,
115
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
171,
176
]
} |
a dna fragment of the broad host range plasmid rp4 carrying the cis-acting dna recognition site for conjugative dna transfer between bacterial cells ( mobsite ) was cloned into the kanamycin-neomycin resistance transposon tn5 . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
0,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
112,
115
]
} |
epinephrine and norepinephrine increased the frequency of vasomotion and reduced mean diameter at low dosages . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} |
chitin and chitosan were found to exhibit a protective effect on mice administered these polysaccharides intraperitoneally against infection of the viable cells of candida albicans nih a-207 strain . | NA | {
"id": "C0008141",
"name": "chitin",
"pos": [
0,
6
]
} | {
"id": "C0162969",
"name": "chitosan",
"pos": [
11,
19
]
} |
a significant difference was observed between the protective effects of chitin and chitosan , i.e. , chitin was much more effective than chitosan when the c. albicans cells were challenged via the intravenous route . | NA | {
"id": "C0008141",
"name": "chitin",
"pos": [
72,
78
]
} | {
"id": "C0162969",
"name": "chitosan",
"pos": [
137,
145
]
} |
in intraperitoneal inoculations of c. albicans cells , however , chitosan provided stronger resistance for mice than chitin . | NA | {
"id": "C0162969",
"name": "chitosan",
"pos": [
65,
73
]
} | {
"id": "C0008141",
"name": "chitin",
"pos": [
117,
123
]
} |
it has also been revealed that the number of polymorphonuclear leukocytes from circulating blood of chitin-administered mice increased remarkably compared with that of untreated and chitosan-treated mice , and that the increase of active oxygen-generating phagocytic cells was significant . | NA | {
"id": "C0008141",
"name": "chitin",
"pos": [
100,
106
]
} | {
"id": "C0162969",
"name": "chitosan",
"pos": [
182,
190
]
} |
on the other hand , the number of peritoneal exudate cells ( pec ) and the amounts of active oxygen generated from these cells in chitosan-treated mice were larger than those of chitin-treated mice . | NA | {
"id": "C0162969",
"name": "chitosan",
"pos": [
130,
138
]
} | {
"id": "C0008141",
"name": "chitin",
"pos": [
178,
184
]
} |
however , candidacidal activities of pec per fixed cell number in mice treated with chitin or with chitosan were almost the same and greater than those of untreated mice . | NA | {
"id": "C0008141",
"name": "chitin",
"pos": [
84,
90
]
} | {
"id": "C0162969",
"name": "chitosan",
"pos": [
99,
107
]
} |
duration of known uraemia , total cumulative aluminium hydroxide consumption , present level of aluminium hydroxide consumption and chronic interstitial nephropathy as primary kidney pathology were all positively correlated to serum aluminium concentration . | NA | {
"id": "C0041948",
"name": "uraemia",
"pos": [
18,
25
]
} | {
"id": "C0022658",
"name": "nephropathy",
"pos": [
153,
164
]
} |
these tumors consisted of 195 adenomas , 140 solitary adenomatous nodules , 121 multiple adenomatous goiters , 31 cysts , and 176 carcinomas . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
6,
12
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
114,
119
]
} |
primary aldosteronism ( 43 cases ) , cushing 's syndrome ( 53 cases ) , pheochromocytoma ( 39 cases ) , and doc-producing tumor ( 1 case ) , whereas , only 3 cases were non-functioning adenoma and cyst . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
122,
127
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
197,
201
]
} |
the third generation cephems , cefotaxime , ceftizoxime , cefmenoxime and latamoxef , have been developed to aim opportunistic gram negative pathogens and applied for surgical infections since 1980 . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
31,
41
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
44,
55
]
} |
the third generation cephems , cefotaxime , ceftizoxime , cefmenoxime and latamoxef , have been developed to aim opportunistic gram negative pathogens and applied for surgical infections since 1980 . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
31,
41
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
58,
69
]
} |
when 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine ( ddc ) is given to animals , it produces a hepatic porphyria resembling human variegate porphyria thus providing an experimental system in which to study this disease . | NA | {
"id": "C0162533",
"name": "hepatic porphyria",
"pos": [
106,
123
]
} | {
"id": "C0162532",
"name": "variegate porphyria",
"pos": [
141,
160
]
} |
treatment with alpha-difluoromethylornithine ( dfmo ) , an enzyme-activated irreversible inhibitor of ornithine decarboxylase ( odc ) , depletes the putrescine and spermidine content , and reduces the growth rate of ehrlich ascites tumor cells . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
149,
159
]
} | {
"id": "C0037871",
"name": "content",
"pos": [
175,
182
]
} |
the addition of putrescine , which is the immediate precursor of spermidine , promptly replenished the intracellular putrescine and spermidine pools and completely reversed the antiproliferative effect of dfmo . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
16,
26
]
} | {
"id": "C0037871",
"name": "pools",
"pos": [
143,
148
]
} |
mg2+ , which can replace putrescine in many in vitro reactions , completely lacked the capacity to reverse the antiproliferative effect of putrescine and spermidine deficiency . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
25,
35
]
} | {
"id": "C0037871",
"name": "deficiency",
"pos": [
165,
175
]
} |
in the present paper on the basis of analysis of literary data it is postulated that along with the aug codon at n743 there exists a second initiation codon in the poliovirus rna ( the aug codon at n586 ) . | NA | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
140,
156
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
189,
194
]
} |
oligoribonucleotide derivatives containing the photoactivated arylazidogroup at 5'-end of the oligonucleotide fragment [ 2- ( n-2,4-dinitro-5-azidophenyl ) aminoethyl ] phosphamides of the oligoribonucleotides , azido-nh ( ch2 ) 2nhpn ( pn ) n-1 , were prepared . | NA | {
"id": "C0028953",
"name": "oligonucleotide",
"pos": [
94,
109
]
} | {
"id": "C0028956",
"name": "oligoribonucleotides",
"pos": [
189,
209
]
} |
it has been found that the testis-specific fraction has in its c-terminal half of the molecule 15 arginine residues and a high proportion of basic amino acid residues ( 0,49 ) and thereby resembles the histone h5 of birds and fishes . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
98,
106
]
} | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
141,
157
]
} |
the n-terminal half of this fraction however is close to the somatic variants of lysine-rich histones by the number of arginine residues and by the proportion of basic amino acid residues . | NA | {
"id": "C0024337",
"name": "lysine",
"pos": [
81,
87
]
} | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
162,
178
]
} |
the n-terminal half of this fraction however is close to the somatic variants of lysine-rich histones by the number of arginine residues and by the proportion of basic amino acid residues . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
119,
127
]
} | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
162,
178
]
} |
the scheme of behaviour of affinity labels is assumed to be as follows : a ) the formation of specific reagent-enzyme complex , b ) the covalent attachment of the reagent to the enzyme , c ) the covalent binding induced disruption of the specific complex formed before . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
111,
125
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
178,
184
]
} |
the amino acid and nucleotide sequences encoded by the unmutated gene predict that a guanine-to-adenine transition is responsible for the glycine-to-aspartic acid mutation at codon 244 and would also result in the loss of a haeiii site . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
138,
145
]
} |
the variants that were deficient in accumulating camp were obtained by using a protocol in which 1 microm 8-bromo-camp was included in addition to the agonist . | NA | {
"id": "C0001455",
"name": "camp",
"pos": [
49,
53
]
} | {
"id": "C0000661",
"name": "8-bromo-camp",
"pos": [
106,
118
]
} |
different 3 ' coding exons in the rat calcitonin gene are used to generate distinct mrnas encoding either the hormone calcitonin in thyroidal c-cells or a new neuropeptide referred to as calcitonin gene-related peptide in neuronal tissue , indicating the rna processing regulation is one strategy used in tissue-specific... | NA | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
38,
48
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
159,
171
]
} |
different 3 ' coding exons in the rat calcitonin gene are used to generate distinct mrnas encoding either the hormone calcitonin in thyroidal c-cells or a new neuropeptide referred to as calcitonin gene-related peptide in neuronal tissue , indicating the rna processing regulation is one strategy used in tissue-specific... | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
159,
171
]
} | {
"id": "C0006669",
"name": "calcitonin gene-related peptide",
"pos": [
187,
218
]
} |
when the cyc1 aug initiation codon preceded the galk aug codon and coding sequence and either the two augs were out of frame with each other or a nonsense codon was located between them , the expression of the galk gene was extremely low . | NA | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
18,
34
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
155,
160
]
} |
furthermore the codon uug , when preceded by an a three nucleotides upstream , served as a better initiation codon than when a u was substituted for the a . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
16,
21
]
} | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
98,
114
]
} |
to assess the factors required for integration and expression of retroviral dna , we have examined viral dna , rna , and protein in nih/3t3 mouse cells transformed by transfection with various forms of cloned rous sarcoma virus ( rsv ) dna . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
70,
79
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
236,
239
]
} |
linear rsv dna molecules , derived from circular dna containing two long terminal repeats ( ltrs ) and permuted by cleavage at the saci restriction endonuclease site in the leader sequence , were integrated near the ends of the linear molecule , with the ltrs on the 3 ' side of the src gene . | NA | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
11,
24
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
40,
52
]
} |
analyses of viral polyadenylated rna , together with the patterns of viral dna in transformed cells , indicated that viral dna can be integrated and expressed without regard to ltr sequences , with adjacent host dna presumably supplying signals required for the promotion and processing of functional src mrna . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
69,
78
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
212,
215
]
} |
disappearance of cairns intermediate dna occurs at the same rate in irradiated and unirradiated cells , whereas completion of the relaxed circular intermediate dna occurs at a slow rate , relatively independent of uv fluence . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
37,
40
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
138,
146
]
} |
the phosphate-binding specificity was further confirmed by inhibition by phosphocholine , inositol hexaphosphate , atp , amp and even sodium phosphate , but not by choline or inositol . | NA | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
73,
87
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
164,
171
]
} |
monoclonal antibodies to native bsa were specific for the homologous antigen , while one of three clones prepared by immunization with denatured bsa produced an antibody cross-reactive with native bsa . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
161,
169
]
} |
the structural components of antigen molecules that interact with class ii major histocompability complex ( mhc ) molecules on antigen-presenting cells ( apcs ) ( agretopes ) and with antigen receptors of t-lymphocytes ( epitopes ) in class ii restricted t-cell responses have not been precisely defined . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
29,
36
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
221,
229
]
} |
these three kinds of antigens are : endopeptidase digests of hcytc , cytochrome c peptides 81-104 of several species and several isolated chymotryptic peptide fragments of hcytc . | NA | {
"id": "C0030956",
"name": "peptides",
"pos": [
82,
90
]
} | {
"id": "C0030935",
"name": "peptide fragments",
"pos": [
151,
168
]
} |
bisulfite-induced deamination of cytosine produces uracil , a thymine analog reported to be mutagenic both in vitro and in vivo . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
51,
57
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
62,
69
]
} |
5 compounds , i.e . o-aminophenol in ta97 and methanol , ethanol , cadmium chloride and cadmium sulfate in ta102 , induced a reproducible increase in revertants over controls , but this was less than 2-fold . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
46,
54
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
57,
64
]
} |
to learn more about the natural history of low-grade non-hodgkin 's lymphoma , we have studied 83 patients in whom the advanced disease was initially managed without therapy . | NA | {
"id": "C0079747",
"name": "low-grade",
"pos": [
43,
52
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
53,
67
]
} |
we report here that gene trans-complementation occurs in cells heterozygous for the hla-d region , resulting in the expression of hybrid hla-dc molecules in addition to the parental forms . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
84,
89
]
} | {
"id": "C0019761",
"name": "hla-dc",
"pos": [
137,
143
]
} |
the structure recognized seems to be a common epitope determinant of human ia antigens , as ( htlv-infected ) t cells primed in vitro to one hla-d/dr specificity display amplified responses to all other hla-d/dr antigens . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
141,
146
]
} | {
"id": "C0019764",
"name": "hla",
"pos": [
203,
206
]
} |
our results show that degranulation occurs spontaneously and reproducibly if the gtp analogue , gtp-gamma-s , and mg-atp are present in the pipette filling solution . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
81,
84
]
} | {
"id": "C0079469",
"name": "gtp-gamma-s",
"pos": [
96,
107
]
} |
this enzyme is also activated by phorbol esters ( for example , 12-o-tetradecanoyl phorbol 13-acetate , tpa ) and this is assumed to account for the pleiotropic effects of tpa on cell function and growth . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
33,
47
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl phorbol 13-acetate",
"pos": [
64,
101
]
} |
most attempts to treat humans affected with mps vi or other mucopolysaccharidoses have been ineffective or logistically prohibitive , but allogeneic bone marrow transplantation ( bmt ) offers promise for cure of certain inborn errors of metabolism . | NA | {
"id": "C0026709",
"name": "mps vi",
"pos": [
44,
50
]
} | {
"id": "C0026703",
"name": "mucopolysaccharidoses",
"pos": [
60,
81
]
} |
the immunoglobulins , which serve as antigen receptors on b cells , have been well characterized with respect to gene structure , unlike the t-cell receptors . | NA | {
"id": "C0034788",
"name": "antigen receptors",
"pos": [
37,
54
]
} | {
"id": "C0034790",
"name": "t-cell receptors",
"pos": [
141,
157
]
} |
these antibodies bind to and immunoprecipitate a phosphoprotein of relative molecular mass 185,000 ( 185 k ) from a dna donor rat neuroblastoma and 13 independent rat neuroblastoma dna transfectants . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
114,
119
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
181,
184
]
} |
the protein contains four distinct domains , and we have observed a marked similarity between the second and fourth domains and the papain-like thiol proteases and calmodulin-like calcium-binding proteins , respectively . | NA | {
"id": "C0030346",
"name": "papain",
"pos": [
132,
138
]
} | {
"id": "C0010661",
"name": "thiol proteases",
"pos": [
144,
159
]
} |
in this way , cell lines have been established that secrete hapten-specific antibodies in which the fc portion has been replaced either with an active enzyme moiety or with polypeptide displaying c-myc antigenic determinants . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
60,
66
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
202,
224
]
} |
we report here experiments in which we have co-transfected the murine cellular gene encoding for p53 with a ras gene into primary rat embryo fibroblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
70,
78
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
141,
152
]
} |
our results indicate that the p53-encoding gene can play a causal role in the conversion of normal fibroblasts into tumorigenic cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
99,
110
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
128,
133
]
} |
compared with the control groups , in the nonsplenectomized patients both the mean relative increments in the level of some positive acute-phase proteins ( such as orosomucoid ) and the mean relative decrements in the level of some negative acute-phase proteins ( such as alpha 2hs-glycoprotein ) were 3 times the values... | NA | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
164,
175
]
} | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
241,
261
]
} |
the latent enzyme may be , therefore , an enzyme -- inhibitor complex or an inactive precursor of cathepsin b due to an altered processing in golgi endoplasmatic reticulum-lysosome compartment . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
11,
17
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
42,
48
]
} |
thyroid hormones effectively inhibited partially purified cyclic amp phosphodiesterase from the anterior and posterior lobes of bovine pituitary gland competitively with the substrate , but thyronine , diiodotyrosine , monoiodotyrosine , thyrotropin , thyrotropin releasing hormone , dexamethasone , and luteinizing horm... | NA | {
"id": "C0040135",
"name": "thyroid hormones",
"pos": [
0,
16
]
} | {
"id": "C0012344",
"name": "diiodotyrosine",
"pos": [
202,
216
]
} |
thyroid hormones effectively inhibited partially purified cyclic amp phosphodiesterase from the anterior and posterior lobes of bovine pituitary gland competitively with the substrate , but thyronine , diiodotyrosine , monoiodotyrosine , thyrotropin , thyrotropin releasing hormone , dexamethasone , and luteinizing horm... | NA | {
"id": "C0040135",
"name": "thyroid hormones",
"pos": [
0,
16
]
} | {
"id": "C0021996",
"name": "monoiodotyrosine",
"pos": [
219,
235
]
} |
l-glutamic acid ( l-glu ) and other excitatory amino acids and amino acid analogs enhanced [ 35s ] thiocyanate ( scn- ) uptake in isolated-resealed synaptic membrane vesicles . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
2,
5
]
} | {
"id": "C0243046",
"name": "excitatory amino acids",
"pos": [
36,
58
]
} |
the inhibition by aoaa , but not that by dtnb , was prevented by increasing the concentration of the pyridoxal phosphate ( plp ) coenzyme . | NA | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
101,
120
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
129,
137
]
} |
in addition , the results are in agreement with the suggestion that phosphatidylcholine and cholesterol are not the primary sites of high-affinity binding [ 3h ] imipramine and [ 3h ] cocaine to brain membranes , although it can not be ruled out that these lipids have different properties in natural biological membrane... | NA | {
"id": "C0025256",
"name": "artificial",
"pos": [
329,
339
]
} | {
"id": "C0023828",
"name": "liposome",
"pos": [
340,
348
]
} |
it was found that polar cholesterol derivatives and exogenous cholesterol contained in lipoprotein complexes greatly enhanced intracellular cholesteryl ester formation . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
24,
35
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
140,
157
]
} |
further evidence of the existence of the acyl-coa : cholesterol acyltransferase ( acat ) in glioblastoma cells came from the conversion of radioactive cholesterol to cholesteryl ester by glial cell homogenates . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
52,
63
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
166,
183
]
} |
s49-reactive antibodies from the rabbit anti-mbp antiserum were directed solely against a sequential determinant comprising residues 69-71 , s49-reactive antibodies from all three antisera reacted in liquid phase with purified intact rat , guinea pig , and bovine mbp showing that the determinant is exposed for b cell r... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
13,
23
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
180,
188
]
} |
the average labeling index ( li ) obtained from a pulse of 3h-thymidine is very high in medulloblastomas and glioblastoma multiforme ( 5-15 % ) , low in well-differentiated gliomas ( less than 1 % ) , and intermediate in anaplastic astrocytomas . | NA | {
"id": "C0025149",
"name": "medulloblastomas",
"pos": [
88,
104
]
} | {
"id": "C0017638",
"name": "gliomas",
"pos": [
173,
180
]
} |
the role of prostaglandins ( pgs ) in the physiological secretion of the adenohypophyseal hormones , growth hormone ( gh ) and thyrotropin ( tsh ) , in the unanesthetized , freely behaving male rat was investigated using pharmacological agents . | NA | {
"id": "C0032016",
"name": "adenohypophyseal hormones",
"pos": [
73,
98
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
101,
115
]
} |
the role of prostaglandins ( pgs ) in the physiological secretion of the adenohypophyseal hormones , growth hormone ( gh ) and thyrotropin ( tsh ) , in the unanesthetized , freely behaving male rat was investigated using pharmacological agents . | NA | {
"id": "C0032016",
"name": "adenohypophyseal hormones",
"pos": [
73,
98
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
127,
138
]
} |
the authors describe their experience with an unusual postoperative syndrome of pseudobulbar palsy occurring a few days after the extirpation of large midline vermian/4th ventricular tumors in children . | NA | {
"id": "C0033790",
"name": "syndrome",
"pos": [
68,
76
]
} | {
"id": "C0522224",
"name": "palsy",
"pos": [
93,
98
]
} |
[ hemoperitoneum caused by spontaneous rupture of a hepatoblastoma in an adult , with arrest of the hemorrhage by peroperative cryoapplication ] . | NA | {
"id": "C0019065",
"name": "hemoperitoneum",
"pos": [
2,
16
]
} | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
100,
110
]
} |
monoclonal antibodies have in fact been used to identify new antigenic determinants in various microorganisms , to show antigenic differences between species , strains , types and development cycles and to reveal the existence of natural antigenic variants . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
61,
83
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
238,
247
]
} |
the toxicology of tin is almost entirely the toxicology of the organic compounds of tin , for the metal itself and its inorganic compounds appear to be nearly harmless for practical purposes . | NA | {
"id": "C0025552",
"name": "metal",
"pos": [
98,
103
]
} | {
"id": "C0021521",
"name": "inorganic compounds",
"pos": [
119,
138
]
} |
epidoxorubicin ( edx ) was administered to a group of 26 patients with acute leukaemia or lymphoma , replacing either daunorubicin or doxorubicin ( dxr ) as a component of multiple-chemotherapy regimens . | NA | {
"id": "C0014582",
"name": "epidoxorubicin",
"pos": [
0,
14
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
134,
145
]
} |
epidoxorubicin ( edx ) was administered to a group of 26 patients with acute leukaemia or lymphoma , replacing either daunorubicin or doxorubicin ( dxr ) as a component of multiple-chemotherapy regimens . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
118,
130
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
134,
145
]
} |
it is of interest that such results were obtained in patients of high median age with dosages of edx much lower than those employed for dxr . | NA | {
"id": "C0014582",
"name": "edx",
"pos": [
97,
100
]
} | {
"id": "C0013089",
"name": "dxr",
"pos": [
136,
139
]
} |
the differential diagnosis of cystlike swelling in the floor of the mouth should include sialolithiasis , mucous retention phenomenon ( mucocele , ranula ) , dermoid and epidermal inclusion cyst , thyroglossal duct cyst , branchial cleft cyst , hemangioma , lymphangioma , cystic hygroma , lipoma , and occasionally pleo... | NA | {
"id": "C0024221",
"name": "lymphangioma",
"pos": [
258,
270
]
} | {
"id": "C0206620",
"name": "cystic hygroma",
"pos": [
273,
287
]
} |
no antigenic determinants were detected in extracts of worms labelled by the chloramine-t method but 3 antigens were detected in extracts of the bolton-hunter labelled worms . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
3,
25
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
103,
111
]
} |
additionally , a robust effect of gender was found with uncatheterized females showing more hypothermia and more gastric disease than uncatheterized males . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
34,
40
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
149,
154
]
} |
hyperphenylalaninemia due to a biopterin synthesis defect was detected in an infant with decreased biopterin and increased neopterin levels in plasma and urine . | NA | {
"id": "C0005562",
"name": "biopterin",
"pos": [
31,
40
]
} | {
"id": "C0068527",
"name": "neopterin",
"pos": [
123,
132
]
} |
one early-morning water sample taken from the family household contained a copper level of 7.8 mg/l , which is above the standard for drinking water ( 1.0 mg/l ) . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
18,
23
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
134,
148
]
} |
all 134 infants received , via nasogastric tube , 100 mg/kg/d of vitamin e daily ( dl-alpha-tocopheryl acetate in mct [ medium-chain triglyceride ] oil ; 150 mosm ) for at least 8 weeks with the first dose administered within the first eight hours of life . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
65,
74
]
} | {
"id": "C0994472",
"name": "dl-alpha-tocopheryl acetate",
"pos": [
83,
110
]
} |
the adduct formation between np2- and i to iii is based on an anion-anion interaction . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
17,
18
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
68,
73
]
} |
the role of the cation is to reduce the coulombic repulsion between the reactants by ion-pair formation . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
16,
22
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
100,
103
]
} |
in control and in leukemic spleens the same glycosaminoglycans were present , that is hyaluronic acid , heparan sulphate , dermatan sulphate , chondroitin-4-sulphate and chondroitin-6-sulphate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
44,
62
]
} | {
"id": "C0019143",
"name": "heparan sulphate",
"pos": [
104,
120
]
} |
in fact in control spleens hyaluronic acid , heparan sulphate and the chondroitin sulphates were present in almost equal proportions , whereas in leukemic spleens the chondroitin sulphate group alone represented almost 9/10 of all the glycosaminoglycans . | NA | {
"id": "C0019143",
"name": "heparan sulphate",
"pos": [
45,
61
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
235,
253
]
} |
the surrounding chromatin , including the tata box regions shows a more typical , but expression dependent nucleoprotein , probably nucleosomal , organization . | NA | {
"id": "C0008546",
"name": "chromatin",
"pos": [
16,
25
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
107,
120
]
} |
the interaction of two water-soluble furocoumarins , 8- ( omega-diethyl aminopropyloxy ) psoralen hydrochloride ( i ) and its 5-isomer ( ii ) , with dna has been investigated by spectroscopic , equilibrium dialysis , hydrodynamic and chiroptical techniques . | NA | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
37,
50
]
} | {
"id": "C0016072",
"name": "psoralen",
"pos": [
89,
97
]
} |
the ability of bd-40 , a dna intercalative ellipticine analogue , to induce dna protein-cross links ( dpls ) in mammalian cell dna was studied by measuring dna extractability with 0.5m kcl . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
23,
28
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
156,
159
]
} |
tachycardia-terminating devices can induce tachycardias , and individual precautions must be taken in order to prevent or minimize the risk of pacemaker reversion of sinus rhythm to paroxysmal tachycardia or hazardous arrhythmias . | NA | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
43,
55
]
} | {
"id": "C0039236",
"name": "paroxysmal",
"pos": [
182,
192
]
} |
( 3 ) even when arrhythmias are associated with reentry , the triggering extrasystole can arise from a focal origin . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
16,
27
]
} | {
"id": "C0340464",
"name": "extrasystole",
"pos": [
73,
85
]
} |
of those patients with ventricular tachycardia , 30 ( 58 % ) remain alive ( mean follow-up 1.1 years ) and use the device for tachycardia termination . | NA | {
"id": "C0042514",
"name": "ventricular",
"pos": [
23,
34
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
126,
137
]
} |
in addition , several cardiac arrhythmias , including rapid ventricular tachycardia , accelerated idioventricular rhythm , and transient av block are frequently observed . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
60,
83
]
} | {
"id": "C0078888",
"name": "accelerated idioventricular rhythm",
"pos": [
86,
120
]
} |
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