text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the following anti-epileptic drugs and metabolites were used in the comparison of hplc with gc : ethosuximide , primidone , phenobarbital , phenytoin , carbamazepine , n-desmethylmethsuximide , and phenylethylmalonediamide . | NA | {
"id": "C3537002",
"name": "anti-epileptic drugs",
"pos": [
14,
34
]
} | {
"id": "C0015043",
"name": "ethosuximide",
"pos": [
97,
109
]
} |
the following anti-epileptic drugs and metabolites were used in the comparison of hplc with gc : ethosuximide , primidone , phenobarbital , phenytoin , carbamazepine , n-desmethylmethsuximide , and phenylethylmalonediamide . | NA | {
"id": "C3537002",
"name": "anti-epileptic drugs",
"pos": [
14,
34
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
112,
121
]
} |
the following anti-epileptic drugs and metabolites were used in the comparison of hplc with gc : ethosuximide , primidone , phenobarbital , phenytoin , carbamazepine , n-desmethylmethsuximide , and phenylethylmalonediamide . | NA | {
"id": "C3537002",
"name": "anti-epileptic drugs",
"pos": [
14,
34
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
140,
149
]
} |
the following anti-epileptic drugs and metabolites were used in the comparison of hplc with gc : ethosuximide , primidone , phenobarbital , phenytoin , carbamazepine , n-desmethylmethsuximide , and phenylethylmalonediamide . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
112,
121
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
124,
137
]
} |
seven isolates of leishmania from mainland china were characterized on the basis of their isoenzyme profiles for 10 enzymes . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
90,
99
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
116,
123
]
} |
the clinical features of c. jejuni infections vary from those of a mild gastroenteritis to a severe enterocolitis . | NA | {
"id": "C0017160",
"name": "gastroenteritis",
"pos": [
72,
87
]
} | {
"id": "C0014356",
"name": "enterocolitis",
"pos": [
100,
113
]
} |
interaction of aspartyl- and valyl-trna-synthetases from muscles of normal and long-fasted rabbits with substrates is accompanied by the essential quenching of tryptophan fluorescence of arsases . | NA | {
"id": "C0042301",
"name": "valyl-trna-synthetases",
"pos": [
29,
51
]
} | {
"id": "C0002529",
"name": "arsases",
"pos": [
187,
194
]
} |
the incorporation of 14c from [ u-14c ] glucose and 3h from 3h2o into the total lipids fatty acids and glycogen of the liver incorporation of 3h from 3h2o into blood glucose was studied in rats totally irradiated in a dose of 14.4 gy . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
40,
47
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
160,
173
]
} |
histopathological examination of the amputated femur disclosed an intimate relation between the old focus of bone infarction and the tumor tissue , which was composed of a mixture of fibroblast-like cells and histiocyte-like cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
183,
193
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
225,
230
]
} |
the cancer cells are distinguished by abnormal levels of dna per cell , which can be quantified with acridine orange , a metachromatic fluorescent dye for dna and rna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
57,
60
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
165,
166
]
} |
commercial dairy cows were given a routine injection of dinoprost tromethamine ( prostaglandin f2 alpha tham ) in the early post partum period . | NA | {
"id": "C0058310",
"name": "dinoprost tromethamine",
"pos": [
56,
78
]
} | {
"id": "C0012471",
"name": "prostaglandin f2 alpha",
"pos": [
81,
103
]
} |
pmn migration inhibition was eliminated in pbl by the addition of polymyxin b , which binds the lipid a moiety of lps . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
96,
103
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
114,
117
]
} |
carrageenan treatment of chickens resulted in splenomegaly and enlargement of bursa but had no effect on the thymus . | NA | {
"id": "C0038002",
"name": "splenomegaly",
"pos": [
46,
58
]
} | {
"id": "C0020564",
"name": "enlargement",
"pos": [
63,
74
]
} |
the growth patterns of mesoblastic nephroma , wilms ' tumour and bone metastasizing renal tumour of childhood ( bmrtc ) are distinct from one another and are therefore useful in distinguishing children 's kidney tumours . | NA | {
"id": "C0206628",
"name": "mesoblastic nephroma",
"pos": [
23,
43
]
} | {
"id": "C0022665",
"name": "kidney tumours",
"pos": [
205,
219
]
} |
the growth patterns of mesoblastic nephroma , wilms ' tumour and bone metastasizing renal tumour of childhood ( bmrtc ) are distinct from one another and are therefore useful in distinguishing children 's kidney tumours . | NA | {
"id": "C0027708",
"name": "wilms",
"pos": [
46,
51
]
} | {
"id": "C0022665",
"name": "kidney tumours",
"pos": [
205,
219
]
} |
[ estrogen content of the blood of men with chronic hepatitis and liver cirrhosis in various phases of the disease ] . | NA | {
"id": "C0023895",
"name": "liver",
"pos": [
66,
71
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
72,
81
]
} |
content of thiamine triphosphate ( ttp ) was studied in rat liver tissue under conditions of normal state , thiamine deficiency and after loading with thiamine . | NA | {
"id": "C0039853",
"name": "thiamine triphosphate",
"pos": [
11,
32
]
} | {
"id": "C0039840",
"name": "thiamine",
"pos": [
151,
159
]
} |
the concentration of ttp in hepatocytes of control animals was found to be 3.2-3.6 micrograms/g , corresponding to 40 % of the total thiamine pool in the cells . | NA | {
"id": "C0039853",
"name": "ttp",
"pos": [
21,
24
]
} | {
"id": "C0039840",
"name": "thiamine",
"pos": [
133,
141
]
} |
the ttp appears to serve as a reserve of vitamin b1 deposited in mitochondria of the cells in which the biosynthesis of thiamine pyrophosphate of their own did not take place . | NA | {
"id": "C0039853",
"name": "ttp",
"pos": [
4,
7
]
} | {
"id": "C0039840",
"name": "vitamin b1",
"pos": [
41,
51
]
} |
a base composition of single-stranded dna regions differed from those of total rat dna mainly due to increase in content of 5-methylcytosine . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
22,
41
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
83,
86
]
} |
the procedure for estimation of the tissue diene conjugates involved extraction with heptane-isopropanol , purification and spectrophotometric measurement of the extinction in the alcohol fraction . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
93,
104
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
180,
187
]
} |
characteristic properties of reactions between heparin and pregnancy proteins are discussed as well as the perspectives of the use of this method for study of proteins reacting with heparin . | NA | {
"id": "C0032974",
"name": "pregnancy proteins",
"pos": [
59,
77
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
159,
167
]
} |
development of pancreatitis was accompanied by a decrease in content of adrenaline and noradrenaline in all the glands studied , while histamine content was increased in pancreas and-unaltered in salivary and lacrimal glands . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
72,
82
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
87,
100
]
} |
this interaction did not occur between retinol and alpha-tocopherol acetate as well as between m-retinyl acetate and alpha-tocopherol . | NA | {
"id": "C1999896",
"name": "alpha-tocopherol acetate",
"pos": [
51,
75
]
} | {
"id": "C0969677",
"name": "alpha-tocopherol",
"pos": [
117,
133
]
} |
the drug was tried on 53 patients with chronic and acute diarrheal syndrome chronic or acute enterocolitis , ulcerous colitis -- chuhc , dyskinesia coli , biliary-colic fistula , crohn 's disease , gastric carcinoma with diarrheal syndrome , postresectional syndrome and some other diseases ) with a very good result . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
67,
75
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
282,
290
]
} |
the 24-h excretion of free , conjugated and total fractions of dopa , dopamine , noradrenaline and adrenaline was studied in 32 patients with diabetes mellitus . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
81,
94
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
99,
109
]
} |
the excretion and metabolism of radiolabelled s-methyl-l-cysteine ( 150 mg orally ) was studied in three male volunteers . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
4,
13
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
18,
28
]
} |
reaction of this reactive free radical with hepatic microsomes led to the covalent spin labelling of microsomal protein . | NA | {
"id": "C0016693",
"name": "free radical",
"pos": [
26,
38
]
} | {
"id": "C0037914",
"name": "spin labelling",
"pos": [
83,
97
]
} |
the 1,2-disubstituted hydrazines and hydrazides , procarbazine and iproniazid , acted similarly to the monosubstituted hydrazines , while 1,2-dimethylhydrazine elicited no response , either in observable spectral changes or loss of co-reactive cytochrome p-450 . | NA | {
"id": "C0022059",
"name": "iproniazid",
"pos": [
67,
77
]
} | {
"id": "C0020233",
"name": "hydrazines",
"pos": [
119,
129
]
} |
the absorption , distribution , metabolism and excretion of [ 14c ] oxmetidine in rat , dog and man has been studied following both i.v . and oral administration . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
32,
42
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
47,
56
]
} |
glutathione-s-transferase ( gst ) from the liver cytosol of phenobarbital ( pb ) -treated rabbits was purified by deae-cellulose , cm-cellulose and hydroxylapatite column chromatography . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
114,
128
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
134,
143
]
} |
in comparison to controls elevated plasma concentrations of threonine , alanine , glutamic acid , glutamine , histidine , methionine , taurine , valine , isoleucine and leucine ; | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
82,
95
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
98,
107
]
} |
the paper concludes with references to the acknowledgement of a disability card in arterial obstructive diseases and to the motor-car driving ability of patients with vascular diseases . | NA | {
"id": "C0003838",
"name": "arterial",
"pos": [
83,
91
]
} | {
"id": "C0042373",
"name": "vascular diseases",
"pos": [
167,
184
]
} |
hemiparesis , paraparesis , pareses of the facial and other cranial nerves as well as segmental pareses can be observed . | NA | {
"id": "C0221166",
"name": "paraparesis",
"pos": [
14,
25
]
} | {
"id": "C0030552",
"name": "pareses",
"pos": [
96,
103
]
} |
the ed50 values ascertained in golden hamsters ( extraintestinal amoebiasis ) and rats ( intestinal amoebiasis ) after the oral route were 136 and 199 mg/kg ( x4 ) , respectively . | NA | {
"id": "C0002438",
"name": "amoebiasis",
"pos": [
65,
75
]
} | {
"id": "C0013370",
"name": "intestinal amoebiasis",
"pos": [
89,
110
]
} |
the authors describe the role of maternal body weight , duration of pregnancy and sex of newborn in the intrauterine growth of the fetus , more exactly in the development of birth weight . | NA | {
"id": "C0005910",
"name": "body weight",
"pos": [
42,
53
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
174,
186
]
} |
at the statement of the weight limit a differentiation is necessary taking into consideration the constitutional difference in the populations as well as the average birth weight of the newborn and the sex . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
24,
30
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
166,
178
]
} |
[ nutritive value of dietary ribonucleic acid and its nucleosides in growing rats on a diet deficient in nonessential amino acid nitrogen . 4. effect of the pyrimidine nucleosides cytidine and uridine on the composition of the body mass and on nitrogen metabolism ] . | NA | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
54,
65
]
} | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
157,
179
]
} |
[ nutritive value of dietary ribonucleic acid and its nucleosides in growing rats on a diet deficient in nonessential amino acid nitrogen . 4. effect of the pyrimidine nucleosides cytidine and uridine on the composition of the body mass and on nitrogen metabolism ] . | NA | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
157,
179
]
} | {
"id": "C0010715",
"name": "cytidine",
"pos": [
180,
188
]
} |
[ nutritive value of dietary ribonucleic acid and its nucleosides in growing rats on a diet deficient in nonessential amino acid nitrogen . 4. effect of the pyrimidine nucleosides cytidine and uridine on the composition of the body mass and on nitrogen metabolism ] . | NA | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
157,
179
]
} | {
"id": "C0041984",
"name": "uridine",
"pos": [
193,
200
]
} |
the influence of cucumarioside , triterpene glycoside obtained from cucumaria japonica ( echinodermata , holoturioidea ) , or sea cucumbers , on the resistance of mice to bordetella pertussis infection ( with the use experimental pertussis meningoencephalitis as a model ) and on the development of immune response to co... | NA | {
"id": "C0006015",
"name": "bordetella",
"pos": [
171,
181
]
} | {
"id": "C0043167",
"name": "pertussis",
"pos": [
330,
339
]
} |
killed s. aureus cells increased the relative content of blood-forming stem cells in the marrow , while in the spleen a rise in both absolute and relative content of such cells occurred , which was detected in the exocolonization test . | NA | {
"id": "C0018956",
"name": "blood-forming stem cells",
"pos": [
57,
81
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
171,
176
]
} |
children with the generalized form of meningococcal infection aggravated by infectious-toxic shock and brain oedema showed a correlation between symptoms of central nervous system dysfunction and diffuse disturbances of cerebral bioelectrical activity combined with the attenuation of the intercentral relationships of t... | NA | {
"id": "C0243026",
"name": "generalized",
"pos": [
18,
29
]
} | {
"id": "C0009450",
"name": "infectious",
"pos": [
76,
86
]
} |
this caused a 50-fold increase of plasma adrenaline and a 15-fold increase of plasma noradrenaline after 90 min . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
41,
51
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
85,
98
]
} |
cytologic smears showed both adenocarcinoma and carcinoid cell populations while the endoscopic biopsy specimen showed only adenocarcinoma . | NA | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
48,
57
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
124,
138
]
} |
by the same preparation , the production of [ 3h ] aldosterone but not [ 3h ] 18-hydroxycorticosterone from [ 1,2-3h ] corticosterone is decreased in a dose-dependent manner by addition of non-radioactive 18-hydroxycorticosterone . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
88,
102
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
205,
229
]
} |
normal newborn rat adrenal cells kept in primary culture up to 2 1/2 months respond to acth stimulation and produced corticosteroid hormones and smaller amounts of 20 alpha-reduced progesterone metabolites . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
117,
131
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
132,
140
]
} |
the effect of occlusion of the abdominal aorta for 10 , 20 and 40 minutes on the concentration of aspartic and glutamic acids , glutamine , glycine , alanine and gamma-amino butyric acid in the anterior and posterior horns of the lumbosacral spinal cord was studied in the dog , further , concentration of amino acids ( ... | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
140,
147
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
306,
317
]
} |
the effect of occlusion of the abdominal aorta for 10 , 20 and 40 minutes on the concentration of aspartic and glutamic acids , glutamine , glycine , alanine and gamma-amino butyric acid in the anterior and posterior horns of the lumbosacral spinal cord was studied in the dog , further , concentration of amino acids ( ... | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
150,
157
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
306,
317
]
} |
the changes were most marked after 40 minutes of occlusion with a rise in concentration of alanine , glutamine and glutamic acid in the dorsal part of grey matter . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
101,
110
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
115,
128
]
} |
in 38 of 55 cases of astrocytoma , glioblastoma , gliosarcoma , and oligoastrocytoma , gfap immunoreactivity was greater in the invading cells as compared with the main part of the neoplasm . | NA | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
21,
32
]
} | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
35,
47
]
} |
according to the immunohistochemical staining patterns , the tumors were able to be divided into two groups : one group consisted of pleomorphic adenoma , adenoid cystic carcinoma , and adenocarcinoma which showed a mixture of keratin- and myosin-positive cells , respectively , mimicking the structures of the intercala... | NA | {
"id": "C0010606",
"name": "adenoid cystic",
"pos": [
155,
169
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
186,
200
]
} |
cultured cells with a high content of the extremely cysteine-rich protein metallothionein ( mt ) have previously been shown to exhibit resistance when exposed to otherwise lethal doses of cis-dichlorodiammineplatinum ( cis-ddp ) , chlorambucil or prednimustine , and to have a significant proportion of intracellular dru... | NA | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
231,
243
]
} | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
247,
260
]
} |
carbidopa , an extracerebral inhibitor of l-aromatic amino acid decarboxylation , increased dose dependently the brain bioavailability of systemically administered 5-htp not only by peripheral enzyme inhibition , but also by inhibition of the decarboxylase activity within the blood-brain barrier as indicated by a rise ... | NA | {
"id": "C0006982",
"name": "carbidopa",
"pos": [
0,
9
]
} | {
"id": "C2917347",
"name": "inhibitor",
"pos": [
29,
38
]
} |
the antidopaminergic potencies of some new substituted benzamides related to remoxipride have been studied in the rat using in vitro ( 3h-spiperone binding ) and in vivo techniques ( antagonism of apomorphine induced stereotypies ) . | NA | {
"id": "C0005029",
"name": "benzamides",
"pos": [
55,
65
]
} | {
"id": "C0073047",
"name": "remoxipride",
"pos": [
77,
88
]
} |
when total 3h-dihydroalprenolol binding and inhibition of total 3h-dihydroalprenolol binding by ( - ) isoprenaline , ( - ) alprenolol and ( +/- ) cyanopindolol was investigated , it was found that all agents were bound to two classes of saturable binding sites . | NA | {
"id": "C0012278",
"name": "dihydroalprenolol",
"pos": [
14,
31
]
} | {
"id": "C0002334",
"name": "alprenolol",
"pos": [
123,
133
]
} |
the effect of three stable adenosine analogues , l-phenylisopropyl-adenosine ( l-pia ) , 2-chloroadenosine , and adenosine 5'-ethylcarboxamide ( neca ) , on cyclic amp accumulation was studied in five different cell lines derived from the nervous system . | NA | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
89,
106
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
113,
122
]
} |
the effect of three stable adenosine analogues , l-phenylisopropyl-adenosine ( l-pia ) , 2-chloroadenosine , and adenosine 5'-ethylcarboxamide ( neca ) , on cyclic amp accumulation was studied in five different cell lines derived from the nervous system . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
27,
36
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
145,
149
]
} |
in n18-neuroblastoma cells , with cholinergic properties , all three analogues caused an increased accumulation of cyclic amp with the following relative order of potency : neca greater than 2-chloroadenosine greater than l-pia . | NA | {
"id": "C0050789",
"name": "neca",
"pos": [
173,
177
]
} | {
"id": "C0001443",
"name": "l-pia",
"pos": [
222,
227
]
} |
the administration of a stable adenosine analogue , l-n6-phenylisopropyladenosine ( l-pia , 0.3 mg/kg i. p. ) , caused a decrease in the accumulation of l-dopa in the rat hippocampus after blockade of aromatic amino acid decarboxylase by nsd 1015 ( 150 mg/kg ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
31,
40
]
} | {
"id": "C0031484",
"name": "l",
"pos": [
230,
231
]
} |
these were extended comminuted fractures , impression fractures , linear fractures ( fissures ) , ethmoidal fractures , as well as a petrosal bone fracture . | NA | {
"id": "C0476171",
"name": "comminuted fractures",
"pos": [
20,
40
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
108,
117
]
} |
the impaired performance of the task by this blood alcohol concentration was ameliorated by prior administration of naloxone at one testing point in the study sequence ( 40 minutes after ingesting the alcohol ) . | NA | {
"id": "C0684262",
"name": "blood alcohol concentration",
"pos": [
45,
72
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
201,
208
]
} |
results are presented of a protocol of hyposensitizing treatment per os in 19 cases of food allergy ( allergy to milk in 8 , to egg in 8 , to fish in 2 , and to orange in one ) . | NA | {
"id": "C0016470",
"name": "food allergy",
"pos": [
87,
99
]
} | {
"id": "C0079840",
"name": "allergy",
"pos": [
102,
109
]
} |
six months of mr produced a marked decrease in the index of myocardial contractility and function associated with a decrease in intracellular ca++ and na+ , and an increase in intracellular k+ , extracellular space , sarcolemmal na+-k+-atpase , and mg++-atpase . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
151,
153
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
254,
260
]
} |
inferoseptal myocardial infarction : another cause of precordial st-segment depression in transmural inferior wall myocardial infarction ? | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
13,
34
]
} | {
"id": "C0340305",
"name": "inferior wall myocardial infarction",
"pos": [
101,
136
]
} |
8 patients were free of tachycardias and 4 had occasional recurrences of svt that required no hospital visit . | NA | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
24,
36
]
} | {
"id": "C0039240",
"name": "svt",
"pos": [
73,
76
]
} |
patients with mac had a higher prevalence of cardiomegaly on chest x-ray ( p less than 0.0001 ) , left atrial and left ventricular enlargement by echocardiography ( p less than 0.0001 ) , precordial murmurs ( p less than 0.0001 ) , diabetes mellitus ( p less than 0.0001 ) , systemic hypertension ( p less than 0.025 ) a... | NA | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
45,
57
]
} | {
"id": "C0149721",
"name": "left ventricular enlargement",
"pos": [
114,
142
]
} |
the overall 24-h recoveries of cholesterol and fatty acid in lymph were similar in the four groups , as were the distribution of lipids among the major lipid fractions and lipoprotein classes of thoracic duct lymph . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
129,
134
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
172,
183
]
} |
in order to evaluate the influence of guar supplementation on plasma lipoproteins and apolipoprotein c-ii ( apoc-ii ) and apolipoprotein c-iii ( apoc-iii ) isoforms ( apoc-iii2 , apoc-iii1 , apoc-iii0 ) , 16 g/day of guar gum were administered to 12 outpatients affected by familial combined hyperlipoproteinemia for a p... | NA | {
"id": "C0052190",
"name": "apolipoprotein c-ii",
"pos": [
86,
105
]
} | {
"id": "C0003594",
"name": "apoc",
"pos": [
191,
195
]
} |
in order to evaluate the influence of guar supplementation on plasma lipoproteins and apolipoprotein c-ii ( apoc-ii ) and apolipoprotein c-iii ( apoc-iii ) isoforms ( apoc-iii2 , apoc-iii1 , apoc-iii0 ) , 16 g/day of guar gum were administered to 12 outpatients affected by familial combined hyperlipoproteinemia for a p... | NA | {
"id": "C0052191",
"name": "apolipoprotein c-iii",
"pos": [
122,
142
]
} | {
"id": "C0003594",
"name": "apoc",
"pos": [
191,
195
]
} |
while low-density lipoprotein cholesterol paralleled the reduction of total plasma cholesterol , we did not observe any change in the cholesterol content of high-density lipoprotein ( hdl ) subfractions ( hdl2 and hdl3 ) during the study . | NA | {
"id": "C0023824",
"name": "low-density lipoprotein cholesterol",
"pos": [
6,
41
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
134,
145
]
} |
a redistribution of the relative content of very low-density lipoprotein apoc-iii isoforms with a significant increase of apoc-iii1 and a decrease of apoc-iii0 was observed after 15 , 30 , and 60 days of guar gum administration . | NA | {
"id": "C0052191",
"name": "apoc-iii",
"pos": [
73,
81
]
} | {
"id": "C0003594",
"name": "apoc",
"pos": [
150,
154
]
} |
glucose , maltose , and maltotriose from amylitic digestion of 10 foods tested in vitro ( expressed as the digestibility index ) and the blood glucose response to 50-g carbohydrate portions of the same foods eaten by diabetics ( expressed as the glycemic index ) , ( r = 0.815 , n = 10 , p greater than 0.01 ) . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
0,
7
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
137,
150
]
} |
plasma triglyceride , cholesterol and low-density lipoprotein cholesterol concentrations decreased significantly , while high-density lipoprotein cholesterol levels tended to rise . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
22,
33
]
} | {
"id": "C0023824",
"name": "low-density lipoprotein cholesterol",
"pos": [
38,
73
]
} |
values of creatine phosphokinase , aspartic aminotransferase , alanine aminotransferase , glucose , triglycerides , urea nitrogen , uric acid , and total bilirubin were higher in men than in women . | NA | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
44,
60
]
} | {
"id": "C0001899",
"name": "alanine aminotransferase",
"pos": [
63,
87
]
} |
alcohol consumption by men correlated positively with aspartic aminotransferase and alanine aminotransferase but not with high-density lipoprotein cholesterol . | NA | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
63,
79
]
} | {
"id": "C0001899",
"name": "alanine aminotransferase",
"pos": [
84,
108
]
} |
mitoxantrone ( nsc-301739 ) is a synthetic amino anthraquinone dna intercalater active in several experimental tumor systems . | NA | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
0,
12
]
} | {
"id": "C0003174",
"name": "anthraquinone",
"pos": [
49,
62
]
} |
in addition to ethanol there is a linear relationship between osmolality and isopropanol or methanol when added in vitro to serum . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
15,
22
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
77,
88
]
} |
in addition to ethanol there is a linear relationship between osmolality and isopropanol or methanol when added in vitro to serum . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
15,
22
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
92,
100
]
} |
hospitalized patients with duodenal or gastric ulcer , pathologic gastric hypersecretory states ( such as zollinger-ellison syndrome ) , gastric outlet obstruction , esophagitis , severe gastritis or duodenitis , sepsis , trauma ( particularly head injury or burns ) , and some patients receiving high-dose corticosteroi... | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
222,
228
]
} | {
"id": "C0006434",
"name": "burns",
"pos": [
259,
264
]
} |
auriculin is a potent vasoactive and natriuretic peptide that was recently isolated and purified from rat atrial tissue . | NA | {
"id": "C0027481",
"name": "auriculin",
"pos": [
0,
9
]
} | {
"id": "C1144709",
"name": "natriuretic peptide",
"pos": [
37,
56
]
} |
we examined the results of one generation of selection for serum cholesterol ( sc ) concentration on low density lipoprotein cholesterol ( ldl-c ) , high density lipoprotein cholesterol ( hdl-c ) , and triglyceride concentrations and weight in baboons ( papio cynocephalus ) . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
65,
76
]
} | {
"id": "C0023822",
"name": "high density",
"pos": [
149,
161
]
} |
abnormalities of chromosome number , such as the autosomal trisomies and sex chromosome aneuploidies , are considered to be sporadic events with low and constant recurrence risk across populations . | NA | {
"id": "C0008626",
"name": "abnormalities of chromosome",
"pos": [
0,
27
]
} | {
"id": "C0002938",
"name": "aneuploidies",
"pos": [
88,
100
]
} |
the prenatal diagnosis of aspartylglucosaminuria ( agu ) , a lysosomal storage disorder of glycoprotein degradation , was made by demonstrating the deficiency of n-aspartylglucosaminidase on cultured cells from a midterm amniotic fluid sample . | NA | {
"id": "C0085078",
"name": "lysosomal storage",
"pos": [
61,
78
]
} | {
"id": "C0268225",
"name": "deficiency",
"pos": [
148,
158
]
} |
complementation studies in which fibroblasts from a gsd ii dog were fused with fibroblasts derived from control dogs and from human patients with different clinical forms of the disease did not lead to restoration of acid alpha-glucosidase activity in the heterokaryon cell populations . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
33,
44
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
269,
273
]
} |
twenty patients were in their first trimester and were receiving diuretics at time of entry to the study : ten patients were allowed to continue their diuretic medication throughout pregnancy ( diuretic group ) , whereas for the other 10 patients , diuretics were discontinued immediately . | NA | {
"id": "C0032979",
"name": "first",
"pos": [
30,
35
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
182,
191
]
} |
concentrations of the stable metabolites of prostaglandin e2 , prostaglandin f2 alpha , and prostaglandin i2 ( prostacyclin ) were quantified by specific radioimmunoassays in the plasma of nonpregnant women , women pregnant in the late third trimester , and women pregnant in the late third trimester with either pregnan... | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
236,
251
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
313,
322
]
} |
kcs activated in vitro by either endotoxins ( lipopolysaccharide ) or lymphokines were rendered highly cytotoxic against syngeneic melanoma or fibrosarcoma target cells . | NA | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
33,
43
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
46,
64
]
} |
the affected animals appear in 25 % of the litters , indicating an autosomal recessive gene , and present with a spontaneous and progressive nephrotic syndrome detected as early as 3-5 weeks and associated with obesity , hypertension , hypoalbuminemia , hypercholesterolemia , and hyperlipidemia . | NA | {
"id": "C0020443",
"name": "hypercholesterolemia",
"pos": [
254,
274
]
} | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
281,
295
]
} |
two of the tumors were pontine astrocytomas , one was a mixed ependymoma and astrocytoma involving the fourth ventricle and the brainstem , and one was an extraspinal malignant astrocytoma in the lumbar region of a young boy who earlier had been diagnosed as having a pontine glioma for which he received radiation treat... | NA | {
"id": "C0014474",
"name": "ependymoma",
"pos": [
62,
72
]
} | {
"id": "C0017638",
"name": "glioma",
"pos": [
276,
282
]
} |
to distinguish between these two possibilities , isolated rat pancreatic islets were perifused with agents that raise intracellular levels of camp [ 3-isobutyl-1-methylxanthine ( ibmx ) and forskolin ] and others that increase intracellular concentrations of ca2+ either by blocking na2+-ca2+ exchange ( ouabain and chol... | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
316,
323
]
} | {
"id": "C0006945",
"name": "carbachol",
"pos": [
386,
395
]
} |
these findings indicate that the adrenal cortex contains approximately 40 % of the total gland content of da and less than 8 % of the total gland content of ne and epi . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
157,
159
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
164,
167
]
} |
freely moving rats were then infused into the lha and vmh with norepinephrine ( ne ) , epinephrine ( e ) , or acetylcholine or intravenously with ne or e . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
66,
77
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
146,
148
]
} |
lymphatic lipid output was measured , and lymph lipoproteins were sized by use of electron microscopy . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
10,
15
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
48,
60
]
} |
based on agarose gel electrophoresis , sizing of intestinal lymph lipoproteins , and also the determination of lipid in the intestinal lymph cm and vldl as separated by ultracentrifugation , vldl were the major lipoproteins present in lymph during the infusion of egg lecithin . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
111,
116
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
211,
223
]
} |
based on agarose gel electrophoresis , sizing of intestinal lymph lipoproteins , and also the determination of lipid in the intestinal lymph cm and vldl as separated by ultracentrifugation , vldl were the major lipoproteins present in lymph during the infusion of egg lecithin . | NA | {
"id": "C0008731",
"name": "cm",
"pos": [
141,
143
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
211,
223
]
} |
based on agarose gel electrophoresis , sizing of intestinal lymph lipoproteins , and also the determination of lipid in the intestinal lymph cm and vldl as separated by ultracentrifugation , vldl were the major lipoproteins present in lymph during the infusion of egg lecithin . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
148,
152
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
211,
223
]
} |
the results suggest that cm and vldl are assembled separately by the enterocytes and indicate the usefulness of l-81 in further investigating the pathways and regulation of intestinal lipoprotein synthesis , assembly , and secretion . | NA | {
"id": "C0008731",
"name": "cm",
"pos": [
25,
27
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
184,
195
]
} |
the results suggest that cm and vldl are assembled separately by the enterocytes and indicate the usefulness of l-81 in further investigating the pathways and regulation of intestinal lipoprotein synthesis , assembly , and secretion . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
32,
36
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
184,
195
]
} |
in contrast , dna , protein , and sucrase activities were elevated in contents from the isolated segments exposed to ea in sensitized rats . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
20,
27
]
} | {
"id": "C0001924",
"name": "ea",
"pos": [
117,
119
]
} |
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