text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
volatile nitrite in the form of amyl nitrite was used for 100 years for the treatment of angina pectoris . | NA | {
"id": "C0028137",
"name": "nitrite",
"pos": [
9,
16
]
} | {
"id": "C0002711",
"name": "nitrite",
"pos": [
37,
44
]
} |
bladder contractions were inhibited by equipotent intracerebroventricular ( icv ) doses of the selective mu-agonist dago [ d-ala2 , mephe4 , gly- ( ol ) 5 ] enkephalin and the delta-agonist dpdpe [ d-pen2 , d-pen5 ] enkephalin . | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
116,
120
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
216,
226
]
} |
bladder contractions were inhibited by equipotent intracerebroventricular ( icv ) doses of the selective mu-agonist dago [ d-ala2 , mephe4 , gly- ( ol ) 5 ] enkephalin and the delta-agonist dpdpe [ d-pen2 , d-pen5 ] enkephalin . | NA | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
190,
195
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
216,
226
]
} |
insulin analogues inhibited 125i-insulin binding with potencies relative to porcine insulin ( % ) : human insulin 100 , rat insulin ( i + ii ) 71 , coypu insulin 47 , rat multiplication stimulating activity 8 , porcine proinsulin 5 , among which the three last values were significantly higher than in rat liver and fat ... | NA | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
76,
91
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
222,
229
]
} |
insulin analogues inhibited 125i-insulin binding with potencies relative to porcine insulin ( % ) : human insulin 100 , rat insulin ( i + ii ) 71 , coypu insulin 47 , rat multiplication stimulating activity 8 , porcine proinsulin 5 , among which the three last values were significantly higher than in rat liver and fat ... | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
100,
113
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
222,
229
]
} |
insulin analogues inhibited 125i-insulin binding with potencies relative to porcine insulin ( % ) : human insulin 100 , rat insulin ( i + ii ) 71 , coypu insulin 47 , rat multiplication stimulating activity 8 , porcine proinsulin 5 , among which the three last values were significantly higher than in rat liver and fat ... | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
219,
229
]
} |
all normal epithelia were stained with the monoclonal cytokeratin antibody kg 8.13 whereas certain monoclonal antibodies stained only simple epithelia . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
66,
74
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
99,
120
]
} |
acyclovir [ 9- ( 2-hydroxyethoxymethyl ) guanine ] is a newly licensed acyclic nucleoside analog that is active in vitro and in vivo against herpes simplex virus ( hsv ) and varicella zoster virus ( vzv ) . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
0,
9
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
41,
48
]
} |
an abnormal pt , with or without an abnormal aptt but with normal results in the other three tests , indicates an abnormal reduction in the vitamin k-dependent clotting factors ( ii , vii , ix , x ) or factor v . | NA | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
160,
176
]
} | {
"id": "C0015491",
"name": "ix",
"pos": [
190,
192
]
} |
an abnormal pt , with or without an abnormal aptt but with normal results in the other three tests , indicates an abnormal reduction in the vitamin k-dependent clotting factors ( ii , vii , ix , x ) or factor v . | NA | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
160,
176
]
} | {
"id": "C0015498",
"name": "factor v",
"pos": [
202,
210
]
} |
in the two cases reported here , acute respiratory failure developed as a manifestation of motor neuron disease ( amyotrophic lateral sclerosis ) . | NA | {
"id": "C0085084",
"name": "motor neuron disease",
"pos": [
91,
111
]
} | {
"id": "C0002736",
"name": "amyotrophic lateral sclerosis",
"pos": [
114,
143
]
} |
if serum samples are taken at 0700 h , there is a slight negative correlation between pp12 concentration and placental weight ( p less than 0.05 ) , but not between pp12 level and birthweight of the child . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
119,
125
]
} | {
"id": "C0005612",
"name": "birthweight",
"pos": [
180,
191
]
} |
it is proposed that acetoacetate utilization by placental mitochondria proceeds via the conversion to acetoacetyl-coa catalysed by 3-oxoacid-coa transferase , and then to acetyl-coa , catalysed by acetoacetyl-coa thiolase . | NA | {
"id": "C0000988",
"name": "acetoacetate",
"pos": [
20,
32
]
} | {
"id": "C0022618",
"name": "oxoacid",
"pos": [
133,
140
]
} |
in contrast , choriocarcinoma cells incorporated substantially more purine bases ( adenine and hypoxanthine ) and nucleoside ( adenosine ) into nucleotides , mainly atp . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
68,
74
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
83,
90
]
} |
the weights of the fetuses in the unilaterally ovariectomized group were not significantly different from those of the controls , thus affording no evidence of a causal connection between fetal weight and gross placental weight . | NA | {
"id": "C0751992",
"name": "fetal weight",
"pos": [
188,
200
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
221,
227
]
} |
the arrhythmia was converted directly into sinus rhythm in 8 patients and into atrial fibrillation followed by spontaneous reversion to sinus rhythm in 2 patients . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
4,
14
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
79,
98
]
} |
experience is too short to evaluate the effectiveness of benzimidazoles ( notably albendazole ) , administered post-operatively or alone when surgery is contra-indicated , in the treatment of hepatic or alveolar hydatid disease . | NA | {
"id": "C0005050",
"name": "benzimidazoles",
"pos": [
57,
71
]
} | {
"id": "C0001911",
"name": "albendazole",
"pos": [
82,
93
]
} |
the procollagen iii aminoterminal peptide immunoassay therefore is a non-invasive and sensitive method for accurate assessment of bone marrow progressive involvement in myeloproliferative diseases associated with myelofibrosis . | NA | {
"id": "C0027022",
"name": "myeloproliferative diseases",
"pos": [
169,
196
]
} | {
"id": "C0001815",
"name": "myelofibrosis",
"pos": [
213,
226
]
} |
[ association of thrombosis and thrombopenia induced by heparin . treatment with a low molecular weight heparin ] . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
56,
63
]
} | {
"id": "C0019139",
"name": "low molecular weight heparin",
"pos": [
83,
111
]
} |
behavioral variables included the frequency of mild intoxication , leisure-time physical activity , cigarette smoking , relative weight , and change in weight . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
129,
135
]
} | {
"id": "C0005911",
"name": "change in weight",
"pos": [
142,
158
]
} |
computer searches of the national biomedical research foundation protein and nucleic acid sequence data bases using the nh2 terminus of the bovine factor va 94-kilodalton heavy chain , the nh2 terminus of the 74-kilodalton factor va light chain , and an internal 98-residue segment of porcine factor viii revealed that b... | NA | {
"id": "C0015501",
"name": "factor va",
"pos": [
147,
156
]
} | {
"id": "C0015498",
"name": "factor v",
"pos": [
352,
360
]
} |
characterization of a somatostatin-28 containing the ( tyr-7 , gly-10 ) derivative of somatostatin-14 : a terminal active product of prosomatostatin ii processing in anglerfish pancreatic islets . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
22,
37
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
86,
101
]
} |
anglerfish ( lophius piscatorius ) brockmann organs contain a form of somatostatin-14 , identical to the hypothalamic tetradecapeptide , and two distinct forms of somatostatin-28 , which can be separated by reversed-phase high-pressure liquid chromatography ( hplc ) . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
70,
85
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
163,
178
]
} |
exposure of this somatostatin-28 species to an endopeptidase activity from the rat brain cortex generates a peptide immunologically related to somatostatin and undistinguishable from synthetic ( tyr-7 , gly-10 ) somatostatin-14 ii by hplc . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
17,
32
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
212,
224
]
} |
one of the clones , ck52g8 , was sequenced by the dideoxy m13 method and was found to encode a mr 42,941 protein , which is 68 % homologous to a known partial sequence of rabbit muscle creatine kinase and which has a composition similar to creatine kinases from chicken and rabbit tissues . | NA | {
"id": "C0010291",
"name": "muscle creatine kinase",
"pos": [
178,
200
]
} | {
"id": "C0010287",
"name": "creatine kinases",
"pos": [
240,
256
]
} |
we could characterize the glutamine residues acting as acyl-donor sites in three beta-crystallin chains , which are the only substrates for lens transglutaminase among the various lens-specific structural proteins , the crystallins . | NA | {
"id": "C0005203",
"name": "beta-crystallin",
"pos": [
81,
96
]
} | {
"id": "C0010422",
"name": "crystallins",
"pos": [
220,
231
]
} |
these experiments support the concept that reca protein first forms a filament with single-stranded dna , which in turn binds to duplex dna to mediate both homologous pairing and subsequent strand exchange . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
84,
103
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
136,
139
]
} |
using sandwich rna hybridizations , we have found that cells expressing igg1 contain nuclear rnas that have both c mu and c gamma 1 sequences , and that cells expressing iga contain nuclear rnas that have both c mu and c alpha sequences . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
15,
18
]
} | {
"id": "C0035700",
"name": "nuclear rnas",
"pos": [
182,
194
]
} |
a bacterial fusion protein constructed from a portion of the reading frame and escherichia coli beta-galactosidase was used to produce sera in rabbits against the previously unidentified gene product . | NA | {
"id": "C0004627",
"name": "bacterial",
"pos": [
2,
11
]
} | {
"id": "C0033684",
"name": "gene",
"pos": [
187,
191
]
} |
two of these antibodies bound to more than one glycine receptor polypeptide : mab glyr 4a stained the 48,000- and 58,000-dalton polypeptides , and mab glyr 7a stained the 48,000- and 93,000-dalton polypeptides . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
13,
23
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
147,
150
]
} |
the presence in pig brain of an endogenous equivalent of apamin , the bee venom peptide that specifically blocks ca2+-dependent k+ channels . | NA | {
"id": "C0003521",
"name": "apamin",
"pos": [
57,
63
]
} | {
"id": "C0004920",
"name": "bee venom",
"pos": [
70,
79
]
} |
electrical stimulation of the superior cervical ganglion of the rat increased the phosphorylation of tyrosine hydroxylase ( tyrosine 3-monooxygenase , ec 1.14.16.2 ) in this tissue . | NA | {
"id": "C0020364",
"name": "hydroxylase",
"pos": [
110,
121
]
} | {
"id": "C0041491",
"name": "tyrosine 3-monooxygenase",
"pos": [
124,
148
]
} |
our results show that intracellular superoxide can be spin-trapped using 5,5-dimethyl-1-pyrroline-1-oxide and that secondary free-radical injury to membrane lipids , due to excess production of partially reduced species of oxygen by intact cells , can be detected by spin-trapping lipid free radicals with phenyl n-tert-... | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
148,
163
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
281,
286
]
} |
the in vitro translation product of the selected mrna was immunoprecipitated by anti-chicken creatine kinase antibodies and comigrated with torpedo muscle creatine kinase on two-dimensional gels at the same position as the cytosolic 43,000-dalton protein referred to as nu 2 . | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
93,
108
]
} | {
"id": "C0010291",
"name": "muscle creatine kinase",
"pos": [
148,
170
]
} |
the presequence contains 8 basic amino acid residues , no acidic residues , and no hydrophobic amino acid stretch . | NA | {
"id": "C0301714",
"name": "basic amino",
"pos": [
27,
38
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
95,
105
]
} |
treatment of human fibroblasts with epidermal growth factor ( egf ) results in a rapid increase ( less than 5 min ) in the ability of the cells to bind 125i-labeled transferrin to surface receptors . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
19,
30
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
138,
143
]
} |
duchenne fibroblasts in calcium-deficient low-serum ( 0.5 % ) medium supported viral replication at a rate 7- to 10-fold greater than did normal cells infected under the same conditions . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
9,
20
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
138,
150
]
} |
therefore , a cell 's ability to grow and support viral replication in calcium-deficient medium can be used to readily distinguish duchenne muscular dystrophy fibroblasts from normal ones . | NA | {
"id": "C0007634",
"name": "cell 's",
"pos": [
14,
21
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
159,
170
]
} |
a fraction of merozoites , labeled with 3h-proline , and containing the membrane proteins and a fraction containing soluble proteins released by the merozoite were added to the glycophorin beads . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
72,
89
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
124,
132
]
} |
profiles of effects of seven benzodiazepines in the present model of agonistic interaction to some extent differed : triazolam , clonazepam and flunitrazepam were more sedating ( reduced timidity only at doses inhibiting locomotion ) while nitrazepam , oxazepam , diazepam and chlordiazepoxide were less sedating ( reduc... | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
29,
44
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
277,
293
]
} |
the behavioral effects of delta-9-tetrahydrocannabinol ( thc ) , one of the major psychoactive cannabinoids in marijuana , were tested in two models of psychostimulant-induced behaviors in rats ( locomotor behavior and stereotyped gnawing ) induced by amphetamine ( amph ) and methylphenidate ( meph ) . | NA | {
"id": "C0039663",
"name": "delta-9-tetrahydrocannabinol",
"pos": [
26,
54
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
95,
107
]
} |
on trials with no delay between sample offset and onset of the choice phase , d-amphetamine produced a bias toward choosing the color that was correct after long samples , suggesting that the birds overestimated the sample durations under amphetamine . | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
78,
91
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
239,
250
]
} |
heart rate at rest and chronotropic effects of catecholamines remained unchanged after chemical sympathectomy , while the arrhythmogenic effects of epinephrine , norepinephrine and isoprenaline were potentiated markedly . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
47,
61
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
181,
193
]
} |
heart rate at rest and chronotropic effects of catecholamines remained unchanged after chemical sympathectomy , while the arrhythmogenic effects of epinephrine , norepinephrine and isoprenaline were potentiated markedly . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
148,
159
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
162,
176
]
} |
[ extraction behavior of polypropylenes . 87. problems in the use of plastic containers for fluid drugs ] . | NA | {
"id": "C0032582",
"name": "polypropylenes",
"pos": [
25,
39
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
69,
76
]
} |
the neurochemical specificity of physiological , biochemical , and psychological responses to dextroamphetamine was tested by pretreating volunteers with haloperidol ( 0.014 mg/kg im ) , propranolol ( 0.1 mg/kg iv ) , thymoxamine ( 0.1 mg/kg iv ) , or placebo prior to 0.3 mg/kg iv amphetamine . | NA | {
"id": "C0011812",
"name": "dextroamphetamine",
"pos": [
94,
111
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
282,
293
]
} |
displacement studies with ltd4 , the selective srs-a antagonist fpl 55712 and with leukotriene c4 revealed respective ki values of 3.4 ; | NA | {
"id": "C0023544",
"name": "ltd4",
"pos": [
26,
30
]
} | {
"id": "C0038091",
"name": "srs-a",
"pos": [
47,
52
]
} |
displacement studies with ltd4 , the selective srs-a antagonist fpl 55712 and with leukotriene c4 revealed respective ki values of 3.4 ; | NA | {
"id": "C0038091",
"name": "srs-a",
"pos": [
47,
52
]
} | {
"id": "C0023542",
"name": "leukotriene c4",
"pos": [
83,
97
]
} |
this finding suggests that factors other than tumor-to-tumor differences in oxygenation produce most of the variability in the radiation responses of individual tumors from an experimental tumor line . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
161,
167
]
} | {
"id": "C0027659",
"name": "experimental tumor",
"pos": [
176,
194
]
} |
the erythrocyte sedimentation rate and the acute phase proteins alpha 1 acid glycoprotein , c-reactive protein and prealbumin were correlated with survival . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
43,
63
]
} | {
"id": "C0029297",
"name": "alpha 1 acid",
"pos": [
64,
76
]
} |
the erythrocyte sedimentation rate and the acute phase proteins alpha 1 acid glycoprotein , c-reactive protein and prealbumin were correlated with survival . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
43,
63
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
92,
110
]
} |
subcellular distribution of somatostatin-14 , somatostatin-28 and somatostatin-28 ( 1-12 ) in rat brain cortex and comparisons of their respective binding sites in brain and pituitary . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
28,
43
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
66,
81
]
} |
subcellular distribution and binding characteristics of the three endogenous peptides somatostatin-14 ( srif-14 ) , somatostatin-28 ( srif-28 ) and somatostatin-28 ( 1-12 ) ( srif-28 ( 1-12 ] derived from preprosomatostatin were investigated in the rat brain cortex . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
116,
131
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
175,
179
]
} |
by forward alpha scattering technique ( fast ) light elements , from hydrogen through fluorine , are shown to be determined nondestructively and simultaneously , though these elements can not be measured satisfactorily by any other physical method . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
69,
77
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
175,
183
]
} |
absence of plasmid dna sequences in non-tumorigenic ( crown gall tumor ) strains of agrobacterium tumefaciens was confirmed by dna-dna hybridization between purified tumor-inducing ( ti ) plasmid dnas isolated from the progenitor tumorigenic strains and 3h-labeled whole cell dnas from tumorigenic strains and their non-... | NA | {
"id": "C0012930",
"name": "tumor",
"pos": [
40,
45
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
276,
280
]
} |
in dogs , treatment with guanabenz , carteolol , and muzolimine for 7 days , reduced the blood pressure responses to bilateral occlusion of the carotid arteries , electric stimulation of central vagus nerve , acetylcholine after atropinization , nicotine , l-noradrenaline , angiotensin ii , l-adrenaline , kc1 and asphy... | NA | {
"id": "C0028351",
"name": "l-noradrenaline",
"pos": [
257,
272
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
294,
304
]
} |
in order to determine whether the recovery from damage of central noradrenergic fibers could be modified by an opioid specific action of morphine , animals treated with the neurotoxin , 6-hydroxydopa ( 6-ohdopa ) , were co-treated with morphine sulfate ( 3.33 mg/kg i.p . ) . | NA | {
"id": "C0026549",
"name": "morphine",
"pos": [
137,
145
]
} | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
236,
252
]
} |
electronystagmographic recordings were performed in 82 patients , 2 to 3 days after a closed head injury with cerebral concussion . | NA | {
"id": "C0085094",
"name": "closed head injury",
"pos": [
86,
104
]
} | {
"id": "C0006107",
"name": "cerebral concussion",
"pos": [
110,
129
]
} |
the result of a study on the modifications of the expectancy wave ( or contingent negative variation ) induced in 10 cases by a new benzodiazepine , midazolam , is reported . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
132,
146
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
149,
158
]
} |
transient global amnesia is a well known syndrome , characterised by sudden loss of short term memory with retrospective amnesia , that appears in otherwise good healthy subjects . | NA | {
"id": "C0338591",
"name": "transient global amnesia",
"pos": [
0,
24
]
} | {
"id": "C0002622",
"name": "amnesia",
"pos": [
121,
128
]
} |
hormone-dependent tumors have a decreased requirement for growth stimulating hormones compared with the normal tissues from which the tumors originate . | NA | {
"id": "C0027661",
"name": "hormone-dependent tumors",
"pos": [
0,
24
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
134,
140
]
} |
radioimmunoassay of the ca 12 5 antigen in ovarian carcinomas : advantages compared with ca 19-9 and cea . | NA | {
"id": "C0003341",
"name": "ca",
"pos": [
24,
26
]
} | {
"id": "C0006613",
"name": "ca 19-9",
"pos": [
89,
96
]
} |
3 ) with the age of the subjects , an increase in the density of the clones ( number of clones per mm2 ) and the density of clonal cells ( number of clonal cells per mm2 ) together with a decrease in the mean number of chondrocytes per clone . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
9,
12
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
219,
231
]
} |
iodinated platelets of a glanzmann thrombasthenia patient failed to show any material precipitated by these antisera or the antiserum luc , known to contain antibodies against both glycoproteins . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
124,
133
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
157,
167
]
} |
suppression was observed against any epitope on such a haptenized immunogen , thus largely excluding cross-reactions at the level of antigen-binding or idiotypy . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
37,
44
]
} | {
"id": "C0003320",
"name": "immunogen",
"pos": [
66,
75
]
} |
both phenomena express the conventional requirements for physical linkage between hapten and immunogen to have an impact on the antibody response against the epitopes of the carrier . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
82,
88
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
158,
166
]
} |
both phenomena express the conventional requirements for physical linkage between hapten and immunogen to have an impact on the antibody response against the epitopes of the carrier . | NA | {
"id": "C0003320",
"name": "immunogen",
"pos": [
93,
102
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
158,
166
]
} |
the role of viral glycoproteins in adcc enhancement was investigated by using a panel of monoclonal antibodies raised in mice against mumps virions . | NA | {
"id": "C0003241",
"name": "adcc",
"pos": [
35,
39
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
89,
110
]
} |
the antibody-containing supernatants from these cultures were usually of high titres and the reactive antibodies of igm isotype . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
4,
12
]
} | {
"id": "C0021017",
"name": "antibodies",
"pos": [
102,
112
]
} |
the sudden and transient loss of consciousness and muscular tone from which the patient usually recovers spontaneously , i.e . syncope , is a frequent symptom . | NA | {
"id": "C0041657",
"name": "loss of consciousness",
"pos": [
25,
46
]
} | {
"id": "C0039070",
"name": "syncope",
"pos": [
127,
134
]
} |
three major mammalian tachykinins have been identified -- substance k , neuromedin k , and substance p -- but only two tachykinin receptors have been postulated . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
22,
33
]
} | {
"id": "C0038581",
"name": "substance k",
"pos": [
58,
69
]
} |
three major mammalian tachykinins have been identified -- substance k , neuromedin k , and substance p -- but only two tachykinin receptors have been postulated . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
22,
33
]
} | {
"id": "C0027847",
"name": "neuromedin k",
"pos": [
72,
84
]
} |
three major mammalian tachykinins have been identified -- substance k , neuromedin k , and substance p -- but only two tachykinin receptors have been postulated . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
22,
33
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
91,
102
]
} |
analysis of the ability of heteroantisera , monoclonal antibodies , and antibodies to synthetic peptides to react with viral glycoproteins deglycosylated with endoglycosidase f revealed that the reactivities of most of the antibodies to these glycoprotein antigens were influenced by the attached carbohydrate moieties . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
44,
65
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
223,
233
]
} |
a human papovavirus , jcv , is the etiologic agent of the fatal demyelinating disease , progressive multifocal leukoencephalopathy . | NA | {
"id": "C0011303",
"name": "demyelinating",
"pos": [
64,
77
]
} | {
"id": "C0023524",
"name": "progressive multifocal leukoencephalopathy",
"pos": [
88,
130
]
} |
then various psychiatric diagnoses are considered in the light of published criteria , including types of psychoses , psychosexual disorders , and personality disorders . | NA | {
"id": "C0004936",
"name": "psychoses",
"pos": [
106,
115
]
} | {
"id": "C0033953",
"name": "psychosexual",
"pos": [
118,
130
]
} |
a diagnosis of sjogren 's syndrome or rheumatoid arthritis was made in five women in whom multiple myeloma was first suspected . | NA | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
15,
34
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
38,
58
]
} |
recrudescence rates and gametocyte rates were highest among children in the 1-4 years age-group and this could be attributed to their lower level of acquired immunity compared to the older children and adults . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
60,
68
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
183,
197
]
} |
although reactions in both serological tests were invariably strongest with homologous antigen : antibody systems , antisera from rabbits immunized with a. fumigatus , blastomyces dermatitidis , candida albicans and paracoccidioides brasiliensis reacted in the elisa test with all of the aspergillus antigens . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
97,
105
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
116,
124
]
} |
although reactions in both serological tests were invariably strongest with homologous antigen : antibody systems , antisera from rabbits immunized with a. fumigatus , blastomyces dermatitidis , candida albicans and paracoccidioides brasiliensis reacted in the elisa test with all of the aspergillus antigens . | NA | {
"id": "C0004037",
"name": "fumigatus",
"pos": [
156,
165
]
} | {
"id": "C0004034",
"name": "aspergillus",
"pos": [
288,
299
]
} |
isolates of neisseria gonorrhoeae from 150 patients attending a venereal disease clinic were examined for their susceptibility to four antibiotics ( norfloxacin , cefotaxime , cefuroxime , and erythromycin ) by a plate-dilution method . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
163,
173
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
176,
186
]
} |
study by phase contrast light microscopy and transmission and scanning electron microscopy found that changes were primarily in the endothelium and consisted of endothelial cell degeneration and loss with focal fibroblastic and epithelial-like cell transformation . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
173,
177
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
211,
223
]
} |
thyroid-stimulating hormone ( 0.3 iu/ml ) , guanosine triphosphate ( 10 ( -4 ) m ) , and gpp ( nh ) p ( 10 ( -4 ) m ) stimulated ac in all thyroid tissues , although in two tissues ( normal ) gpp ( nh ) p failed to cause a significant increase . | NA | {
"id": "C0018353",
"name": "guanosine triphosphate",
"pos": [
44,
66
]
} | {
"id": "C0018366",
"name": "gpp",
"pos": [
192,
195
]
} |
isoproterenol ( 10 ( -4 ) m ) , in contrast , had no effect on basal ac activity or on guanosine triphosphate , and gpp ( nh ) p stimulated ac activity in 26 of the 29 thyroid tissues . | NA | {
"id": "C0018353",
"name": "guanosine",
"pos": [
87,
96
]
} | {
"id": "C0018366",
"name": "gpp",
"pos": [
116,
119
]
} |
thyroid disease consisted of 21 cancers , six adenomas , four colloid goiters , and two cases of thyroiditis resulting in four deaths caused by cancer , for a 20 % mortality rate . | NA | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
0,
15
]
} | {
"id": "C0040147",
"name": "thyroiditis",
"pos": [
97,
108
]
} |
the material consisted of 17 children , who had been advised to suck on 1 naf tablet ( fludent , 0.25 mg f ) daily at bedtime from 3 to 6 years of age ( test group ) , and 17 children without tablet supply ( control group ) . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
74,
77
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
145,
146
]
} |
it was concluded that the posteruptively increased enamel fluorine concentration probably contributes to the caries-preventive effect of naf tablets . | NA | {
"id": "C0016327",
"name": "fluorine",
"pos": [
58,
66
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
137,
140
]
} |
a number of low molecular weight heparin fractions produce less bleeding than standard heparin for an equivalent antithrombotic effect in experimental animals . | NA | {
"id": "C0019139",
"name": "low",
"pos": [
12,
15
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
87,
94
]
} |
for a similar antithrombotic effect , standard heparin produced significantly more bleeding than the other 3 glycosaminoglycans . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
47,
54
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
109,
127
]
} |
standard heparin had a greater inhibitory effect on collagen-induced platelet aggregation than the low molecular weight glycosaminoglycans , supporting the possibility that the increased bleeding observed with heparin is related in part to its inhibitory effect on platelet function . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
120,
138
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
210,
217
]
} |
in addition , the effect of protamine exposure to heparin-alcohol and lmw heparin-alcohol treated grafts as well as native human umbilical veins ( huv ) was studied . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
50,
57
]
} | {
"id": "C0019139",
"name": "lmw heparin",
"pos": [
70,
81
]
} |
surface-bound lmw heparin exhibited a significantly lower ability to inactivate thrombin as compared with conventional heparin , but lmw heparin-alcohol surfaces were better than non-heparinized ones . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
18,
25
]
} | {
"id": "C0019139",
"name": "lmw heparin",
"pos": [
133,
144
]
} |
the findings indicate that lmw heparin , despite its weaker thrombin inhibiting capacity , may be an alternative to conventional heparin , for `` '' heparinizing '' '' the human umbilical vein graft . | NA | {
"id": "C0019139",
"name": "lmw",
"pos": [
27,
30
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
149,
156
]
} |
streptokinase- ( human ) plasmin activator complex ( sk-pm ) and brl 26921 ( p-anisoylated streptokinase- ( human ) plasminogen activator complex ) were each given at equivalent doses ( 28,500 iu/kg and 800 micrograms/kg respectively ) to groups of beagle dogs by rapid injection over 10 sec and their effects on blood p... | NA | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
0,
13
]
} | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
116,
137
]
} |
aspartic acid , proline , glycine , threonine , glutamic acid , valine , serine and alanine were the major amino acids , amounting to 82-89 % in total , in these acidic glycopeptides , although their contents differed from each other . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
26,
33
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
107,
118
]
} |
aspartic acid , proline , glycine , threonine , glutamic acid , valine , serine and alanine were the major amino acids , amounting to 82-89 % in total , in these acidic glycopeptides , although their contents differed from each other . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
84,
91
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
107,
118
]
} |
neonatal rat hearts were separated into separate cultures of beating myocytes ( m cells ) , endothelial cells ( e cells ) and fibroblasts ( f cells ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
126,
137
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
142,
147
]
} |
separate cultures of beating myocytes ( m cells ) , endothelial cells ( e cells ) and fibroblasts ( f cells ) from neonatal rat hearts were compared for their susceptibilities to the toxic effects of doxorubicin , 5-fluorouracil and cyclophosphamide . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
86,
97
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
102,
107
]
} |
cells were exposed to the anti-tumor agents for 3 days with myocytes and 7 days for endothelial cells and fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
0,
5
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
106,
117
]
} |
this paper describes efforts to determine whether 2-hexanone or 2,5-hexanedione is more neurotoxic than 2-hexanone and that it first affects the distal axon . | NA | {
"id": "C0025708",
"name": "2-hexanone",
"pos": [
50,
60
]
} | {
"id": "C0019464",
"name": "hexanone",
"pos": [
106,
114
]
} |
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