text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
to maintain a constant internal ionic content and volume , they must continuously adjust the passive cation permeabilities of their membranes as the rate of transport varies . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
32,
37
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
101,
107
]
} |
exposure of larvae to high concentrations of glutamate , glycine , or serine ( greater than 50 microm ) produces large increases in these substrates in the internal pool of faa . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
57,
64
]
} | {
"id": "C0002520",
"name": "faa",
"pos": [
173,
176
]
} |
analysis of data indicates that abnormally high internal serine leads to carrier-mediated efflux of serine as well as other neutral amino acids . | NA | {
"id": "C0036720",
"name": "serine",
"pos": [
57,
63
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
124,
143
]
} |
it is suggested that results be expressed as the rosette inhibition antibody concentration ( riac ) or the more accurate extrapolated 25 % rosette inhibition antibody concentration ( 25 % riac ) , in place of the previously used rosette inhibition titer ( rit ) , when monoclonal antibodies are used . | NA | {
"id": "C0003241",
"name": "riac",
"pos": [
93,
97
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
269,
290
]
} |
in the tumors , vimentin was present in occasional periductular myoepithelial cells , stellate myxoid cells , and especially in chondroid cells and chondrocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
78,
83
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
148,
160
]
} |
since : 1 ) dfmo has very low toxicity , 2 ) suramin is one of the least toxic of the presently used trypanocides , and 3 ) suramin and dfmo act synergistically in mouse models of both acute and late stage trypanosomiasis , we conclude that this combination offers special promise in the treatment of african trypanosomi... | NA | {
"id": "C0041227",
"name": "trypanosomiasis",
"pos": [
206,
221
]
} | {
"id": "C0041228",
"name": "african trypanosomiasis",
"pos": [
301,
324
]
} |
among the amicrofilaremic patients , 47 % of those with lymphedema , lymphangitis , hydrocele , etc. , and 25 % of those with elephantiasis had circulating antigen . | NA | {
"id": "C0024236",
"name": "lymphedema",
"pos": [
56,
66
]
} | {
"id": "C0013882",
"name": "elephantiasis",
"pos": [
126,
139
]
} |
it may be induced by sensitization with a variety of antigens ( viruses , allografts , parasites , fungal antigens , etc . ) in incomplete freund 's adjuvant and elicited by skin testing 7 days later with the specific antigens . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
53,
61
]
} | {
"id": "C0003330",
"name": "fungal",
"pos": [
99,
105
]
} |
in vivo changes were followed with a calcium electrode positioned in the animal 's aorta , and this showed that the ionisation of calcium gluconate on its first pass through the circulation is as great as that of calcium chloride . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
37,
44
]
} | {
"id": "C0006686",
"name": "calcium chloride",
"pos": [
213,
229
]
} |
we conclude from this study that 1 ) the mucous secretory granule contains carbohydrate throughout all phases of the granule , 2 ) the mucous granule contains periodate-reactive sulfated glycoconjugates , with sulfate esters concentrated in the core of the granule , and 3 ) the mucous granules of rhesus trachea morphol... | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
75,
87
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
187,
202
]
} |
anesthesia was induced with either fentanyl ( 75 micrograms/kg ) , sufentanil ( 15 micrograms/kg ) , or alfentanil ( 125 micrograms/kg ) . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
35,
43
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
67,
77
]
} |
anesthesia was induced with either fentanyl ( 75 micrograms/kg ) , sufentanil ( 15 micrograms/kg ) , or alfentanil ( 125 micrograms/kg ) . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
35,
43
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
104,
114
]
} |
however , initial reports concerning two of the newer agonist opioids , sufentanil and alfentanil , suggest that they may prove to be suitable alternatives and perhaps provide advantages over morphine and fentanyl in patients with or without cardiovascular disease . | NA | {
"id": "C1883695",
"name": "agonist opioids",
"pos": [
54,
69
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
72,
82
]
} |
however , initial reports concerning two of the newer agonist opioids , sufentanil and alfentanil , suggest that they may prove to be suitable alternatives and perhaps provide advantages over morphine and fentanyl in patients with or without cardiovascular disease . | NA | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
72,
82
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
205,
213
]
} |
however , initial reports concerning two of the newer agonist opioids , sufentanil and alfentanil , suggest that they may prove to be suitable alternatives and perhaps provide advantages over morphine and fentanyl in patients with or without cardiovascular disease . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
87,
97
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
205,
213
]
} |
the presence in serum of ige antibodies to food antigens is not uncommon in some patients with atopic dermatitis , although the clinical relevance of the antibodies for the dermatitis is not always clear . | NA | {
"id": "C0011615",
"name": "atopic dermatitis",
"pos": [
95,
112
]
} | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
173,
183
]
} |
high concentrations of ige antibodies not only to classical food antigens such as egg , fish , cow 's milk , nuts , shellfish , peanuts and cereals but also to less typical allergens such as celery , some spices and other vegetables often indicate a pronounced food allergy that can give rise to a serious reaction upon ... | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
65,
73
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
173,
182
]
} |
only six patients had emetine or cephaeline in their blood by two hours ( range , 5 to 73 ng/ml ) , although ten patients had detectable concentrations of the alkaloids in their urine . | NA | {
"id": "C0013974",
"name": "emetine",
"pos": [
22,
29
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
159,
168
]
} |
an attenuation of eia and a tendency to less asthma after budesonide therapy suggest a decrease in bronchial reactivity , but the results gave no clear evidence of an association between nasal airway function and asthma . | NA | {
"id": "C0004099",
"name": "eia",
"pos": [
18,
21
]
} | {
"id": "C0004096",
"name": "asthma",
"pos": [
213,
219
]
} |
subjects were challenged , on separate days , with 50 mg of mb in citric acid and so2 gas , via a steady-state system , at increasing concentrations ( 0.5 , 1.5 , 3 , 5 ppm ) . | NA | {
"id": "C0038777",
"name": "so2",
"pos": [
82,
85
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
86,
89
]
} |
in five patients , only chrysotile ore components ( chrysotile and tremolite/actinolite/anthophyllite types of amphibole asbestos ) were found , while the sixth patient presented both chrysotile ore components and amosite , a type of asbestos that is not derived from the mining process . | NA | {
"id": "C0206121",
"name": "amphibole asbestos",
"pos": [
111,
129
]
} | {
"id": "C0051740",
"name": "amosite",
"pos": [
214,
221
]
} |
in five patients , only chrysotile ore components ( chrysotile and tremolite/actinolite/anthophyllite types of amphibole asbestos ) were found , while the sixth patient presented both chrysotile ore components and amosite , a type of asbestos that is not derived from the mining process . | NA | {
"id": "C0206121",
"name": "amphibole asbestos",
"pos": [
111,
129
]
} | {
"id": "C0003947",
"name": "asbestos",
"pos": [
234,
242
]
} |
unstimulated blood and nonadherent lung mononuclear cells had no consistent effect on fibroblast growth , whereas pha stimulated cells inhibited fibroblast growth in a dose-dependent fashion . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
52,
57
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
145,
155
]
} |
age , sex , lavage cell yield and differential , peripheral lymphocyte count , and percentage of activated t-lymphocytes did not differentiate patients whose mononuclear cells spontaneously inhibited fibroblast growth from those patients whose cells did not . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
200,
210
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
244,
249
]
} |
however , patients whose lung mononuclear cells spontaneously inhibited fibroblast growth had fewer pulmonary function abnormalities than did patients whose cells did not . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
72,
82
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
157,
162
]
} |
both inhibitors were specific for neutrophil elastase and did not affect pancreatic elastase or trypsin . | NA | {
"id": "C0064833",
"name": "neutrophil elastase",
"pos": [
34,
53
]
} | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
73,
92
]
} |
inhibition depended on ionic interaction with the cationic enzyme and could be blocked by 0.15 m nacl . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
23,
28
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
50,
58
]
} |
the effects of variations in blood glucose were made allowance for by using molar c-peptide/glucose ratio . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
29,
42
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
92,
99
]
} |
the results of routine assay in 5 other patients groups are reported : 30 spontaneous sle ( 9 positive aha ) , 63 rheumatoid arthritis ( 2 positive aha ) , 19 sjogren syndrome ( no aha ) , 11 primary biliary cirrhosis ( 1 positive aha ) and 7 mixed connective tissue disease ( no aha ) . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
114,
134
]
} | {
"id": "C1527336",
"name": "sjogren syndrome",
"pos": [
159,
175
]
} |
carbohydrates and amino acids ( except for glycine ) were not used as carbon and energy sources . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
18,
29
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
43,
50
]
} |
four cases of different types of orbital , benign and malignant histiocytosis syndromes are presented to demonstrate the diagnostic presentation , medical evaluation , and therapy of these diseases with orbital involvement . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
78,
87
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
189,
197
]
} |
the endolymphatic ducts and sacs of 25 temporal bones with idiopathic endolymphatic hydrops from individuals with meniere 's disease were studied and compared with the same number of control bones without endolymphatic hydrops from individuals with no premortem history of otologic disease . | NA | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
114,
132
]
} | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
205,
226
]
} |
extraadrenal paragangliomas are tumors of the paraganglion system , usually arising from the carotid bodies , the glomus jugulare , or the glomus tympanicum . | NA | {
"id": "C0030422",
"name": "extraadrenal paragangliomas",
"pos": [
0,
27
]
} | {
"id": "C0030421",
"name": "tumors of the paraganglion",
"pos": [
32,
58
]
} |
the administration of cd ( 3 mg per kg , s.c. , three days ) increased the urinary excretions of lactic dehydrogenase ( ldh ) , glutamic oxalacetic transaminase ( got ) , and total proteins , decreased renal activities ldh and got and increased concentration in kidney tissue of cd , cu , and zn , cadmium also increased... | NA | {
"id": "C0002594",
"name": "got",
"pos": [
163,
166
]
} | {
"id": "C0001899",
"name": "gpt",
"pos": [
415,
418
]
} |
the concentration of serum na+ and k+ ions also demonstrated marked diurnal changes but unlike prolactin levels , the highest cation concentrations were encountered during mid darkphase and the lowest at the middle of photophase . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
38,
42
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
126,
132
]
} |
na+- and k+ -dependent adenosine triphosphatase [ ( na+ + k+ ) -atpase ] plays a pivotal role in the homeostasis of na+ , k+ , and ca2+ in cells . | NA | {
"id": "C0001473",
"name": "adenosine triphosphatase",
"pos": [
23,
47
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
116,
118
]
} |
because high extracellular k+ concentrations ( 18-20 mm ) increased glial na+- and k+ -dependent adenosine triphosphatase [ ( na+ + k+ ) -atpase ] activities , while this increase was not observed in neuronal preparations , it is hypothesized that k+ released in the extracellular space during neuronal firing is activel... | NA | {
"id": "C0001473",
"name": "adenosine triphosphatase",
"pos": [
97,
121
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
299,
301
]
} |
together with genetic studies using restriction-fragment-length polymorphisms , these experiments should distinguish between the respective contributions of genetic and environmental factors in multifactorial forms of partial epilepsies , such as temporal lobe epilepsy . | NA | {
"id": "C0014547",
"name": "partial epilepsies",
"pos": [
218,
236
]
} | {
"id": "C0014556",
"name": "temporal lobe epilepsy",
"pos": [
247,
269
]
} |
these data would be consistent with an impairment of gaba-mediated inhibitory synaptic transmission that contributes to susceptibility to the genesis or spread of seizures in some kinds of epilepsy . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
163,
171
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
189,
197
]
} |
the quantum-chemical estimation of the highest occupied molecular orbital energy for the aglycons of carminomycin , rubomycin , adriamycin and aclacinomycin a in the neutral and ionized states was performed with a semiempirical method . | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
101,
113
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
116,
125
]
} |
on the basis of the quantum-chemical and experimental data it was concluded that the electron donor properties amplified as follows : aclacinomycin a less than adriamycin-rubomycin less than carminomycin . | NA | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
171,
180
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
191,
203
]
} |
the effect of levorene on the intracellular level of the neutral amino acids was higher than that on the main amino acids which was associated with different sensitivity of the amino acid transport systems to the antibiotic . | NA | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
57,
76
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
110,
121
]
} |
the cells of enterobacter aerogenes 11030 contained beta-lactamases of classes v and iii and the cells of klebsiella pneumonia 970 beta-lactamases of classes ii and iii . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
52,
67
]
} | {
"id": "C0728805",
"name": "beta-lactamases",
"pos": [
131,
146
]
} |
a single administration of the ld50 of bruneomycin , carminomycin , rubomycin or olivomycin and the use of the antibiotics for 10 days in a dose 2 times higher than the therapeutic one and amounting to 10 per cent of the ld50 induced dystrophic and destructive changes in the sexual glands of mice . | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
53,
65
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
68,
77
]
} |
recovery processes were observed in the testis beginning from the middle of the third week after the use of carminomycin and rubomycin and from the end of the second week after the use of olivomycin . | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
108,
120
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
125,
134
]
} |
the 12 antimicrobial agents tested were ampicillin , amoxicillin , clindamycin , chloramphenicol , erythromycin , furazolidone , norfloxacin , nalidixic acid , rosoxacin , rosaramicin , tetracycline , and sch 32063 . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
40,
50
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
53,
64
]
} |
the in vitro activity of enoxacin ( ci 919 , at 2266 ) , a new oral quinolone carboxylic acid compound , was compared with those of gentamicin , tobramycin , amikacin , azlocillin , piperacillin , aztreonam , moxalactam , imipenem , cefsulodin , ceftazidime , and cefoperazone against 101 aminoglycoside-susceptible and ... | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
132,
142
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
324,
338
]
} |
all the strains were resistant to trimethoprim but were susceptible to clavulanate-potentiated amoxicillin ( augmentin ; beecham research laboratories , london ) , chloramphenicol , co-trimoxazole , erythromycin , cefotaxime , and cefuroxime . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
214,
224
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
231,
241
]
} |
glycosidases ( alpha-1,6-glucosidase , alpha-1,4-glucosidase , beta-1,4-glucosidase , and beta-1,4-xylosidase ) were induced in b. ovatus b4-11 by crude hemicellulose and heteroxylan . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
0,
12
]
} | {
"id": "C0017764",
"name": "glucosidase",
"pos": [
72,
83
]
} |
glycosidases ( alpha-1,6-glucosidase , alpha-1,4-glucosidase , beta-1,4-glucosidase , and beta-1,4-xylosidase ) were induced in b. ovatus b4-11 by crude hemicellulose and heteroxylan . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
0,
12
]
} | {
"id": "C0043376",
"name": "xylosidase",
"pos": [
99,
109
]
} |
glycosidases ( alpha-1,6-glucosidase , alpha-1,4-glucosidase , beta-1,4-glucosidase , and beta-1,4-xylosidase ) were induced in b. ovatus b4-11 by crude hemicellulose and heteroxylan . | NA | {
"id": "C0015278",
"name": "alpha-1,4-glucosidase",
"pos": [
39,
60
]
} | {
"id": "C0017764",
"name": "glucosidase",
"pos": [
72,
83
]
} |
we have been treating such patients with a combination chemotherapy consisting of vincristine 0.25 mg/day i.v . push daily for 4 days , pepleomycin 5 mg/day s.c. by continuous infusion daily for 4 days , and prednisolone 1 g/day p.o . or methylprednisolone 1 g/day d.i.v . every other day for 4 days pop combination ) ad... | NA | {
"id": "C0032950",
"name": "g/day",
"pos": [
100,
105
]
} | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
238,
256
]
} |
twelve patients with advanced non-hodgkin 's lymphoma , including 8 t-cell lymphoma patients , entered this pilot study when they were cytopenic or had been treated with cytotoxic agents or radiation therapy immediately prior to pop therapy . | NA | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
30,
53
]
} | {
"id": "C0079772",
"name": "t-cell lymphoma",
"pos": [
68,
83
]
} |
blm is a bifunctional compound comprised of a binding site to dna and a reaction site with dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
62,
65
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
93,
94
]
} |
vitamin e ( dl-alpha tocopherol acetate ) , 800 mg/day , was then administered for up to three months , and dapsone therapy was continued at the same dose . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
0,
9
]
} | {
"id": "C0994472",
"name": "dl-alpha tocopherol acetate",
"pos": [
12,
39
]
} |
two japanese outbreaks of erythema infectiosum were investigated for evidence of human parvovirus infection by a solid phase antibody capture radioimmunoassay based on a monoclonal antibody to human parvovirus . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
125,
133
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
170,
189
]
} |
significantly higher mean serum pp12 levels were found in the third trimester in two high risk pregnancy groups ( 281.09 +/- 117.08 micrograms/l in pre-eclamptic toxaemia and 203.71 +/- 73.77 micrograms/l in diabetes ) while serum pp12 levels remained normal ( 114.94 +/- 58.06 micrograms/l ) in twin pregnancy . | NA | {
"id": "C0032981",
"name": "third",
"pos": [
62,
67
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
301,
310
]
} |
this new technique redirects the anomalous pulmonary venous flow into the left atrium through the cardiac end of the svc , transected and oversewn above the anomalous pulmonary vein or veins , by coaptation of the atrial septal defect ( or of the surgically created septal defect in patients with an intact atrial septum... | NA | {
"id": "C0018817",
"name": "atrial septal defect",
"pos": [
214,
234
]
} | {
"id": "C0018816",
"name": "septal defect",
"pos": [
266,
279
]
} |
the order of potencies for inducing vasoconstriction was epinephrine greater than norepinephrine greater than phenylephrine greater than methoxamine greater than dopamine much greater than tyramine greater than clonidine greater than or equal to xylazine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
57,
68
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
82,
96
]
} |
two had received a drug containing a sulfhydryl group ( methimazole and penicillamine ) as treatment for an autoimmune disorder ( graves ' disease and rheumatoid arthritis , respectively ) . | NA | {
"id": "C0004364",
"name": "autoimmune disorder",
"pos": [
108,
127
]
} | {
"id": "C0018213",
"name": "graves",
"pos": [
130,
136
]
} |
in 12 arrhythmias with more varied mechanisms ( extrasystoles , tachysystole , paroxysmal atrial fibrillation ) an intermediate score was obtained ( 2.8 ) . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
6,
17
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
48,
61
]
} |
both anatomical and functional benefits were recorded in frykman type v , vi , and viii fractures and in the group of displaced intra-articular fractures . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
88,
97
]
} | {
"id": "C0332715",
"name": "intra-articular fractures",
"pos": [
128,
153
]
} |
each of the groups v-x , defining a specific infectious category , can also use the aps , which has been verified in patients in intensive care and in those with intra-abdominal infection . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
45,
55
]
} | {
"id": "C1112209",
"name": "intra-abdominal infection",
"pos": [
162,
187
]
} |
dogs and baboons were infused intravenously ( iv ) with escherichia coli and treated with the opiate antagonist , naloxone hydrochloride , and the antibiotic , gentamicin sulfate , to determine the therapeutic efficacy of naloxone . | NA | {
"id": "C0700549",
"name": "naloxone hydrochloride",
"pos": [
114,
136
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
222,
230
]
} |
bovine testicular cells treated at 40 degrees c for 24 hours with high concentrations of bhv-2-induced bovine monocyte interferon or bhv-2 antigen-stimulated immune peripheral blood leukocyte interferon , and then infected with bhv-2 and retreated with interferon at 40 degrees c , had little or no viral growth or cytop... | NA | {
"id": "C0021745",
"name": "immune",
"pos": [
158,
164
]
} | {
"id": "C0021747",
"name": "interferon",
"pos": [
253,
263
]
} |
the investigation has been performed in 132 kidneys of corpses of persons at various ages , 96 of them died from some cardiovascular diseases and 36 -- from mechanical asphyxia . | NA | {
"id": "C0006629",
"name": "corpses",
"pos": [
55,
62
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
103,
107
]
} |
before that the pieces taken from various parts of surgical material were put into one block by means of tissue protein or 5 % egg albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
112,
119
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
131,
138
]
} |
cynomolgus monkeys were anesthetized with either intravenous ( iv ) ketamine hydrochloride , iv ketamine and intramuscular ( im ) diazepam , im methohexital sodium and im pentobarbital sodium , or endotracheal halothane . | NA | {
"id": "C0700541",
"name": "ketamine",
"pos": [
68,
76
]
} | {
"id": "C0022614",
"name": "ketamine",
"pos": [
96,
104
]
} |
plasma low density lipoprotein ( ldl ) kinetics and their relation to plasma very low density lipoprotein ( vldl ) and ldl composition were determined in patients with familial combined hyperlipidemia ( fchl ) of varying lipoprotein phenotypes . | NA | {
"id": "C0023825",
"name": "very",
"pos": [
77,
81
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
221,
232
]
} |
furthermore , the isolated apoprotein mixture was less soluble in urea solutions and formed a gel , probably as a result of cross-linking by inter-protein disulfides . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
27,
37
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
147,
154
]
} |
a child with the classical signs and symptoms of type 1 glycogen storage disease is presented , who on investigation was shown to have a recently described variant of this disease known as type 1b glycogen storage disease . | NA | {
"id": "C0017920",
"name": "type 1 glycogen storage disease",
"pos": [
49,
80
]
} | {
"id": "C0017919",
"name": "glycogen storage disease",
"pos": [
197,
221
]
} |
kinetic analysis of the ca2+-stimulated reaction showed that the apparent km of factor x was 4.6 microm , whereas the apparent vmax . for factor xa formation was 0.0088 mol of xa/min per mol of ixa . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
80,
88
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
138,
147
]
} |
inhibition experiments with unlabelled ha and oligosaccharides from ha indicate that each molecule is bound by several receptors acting co-operatively and that the single receptor recognizes a tetra- or hexa-saccharide sequence of the polysaccharide . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
46,
62
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
235,
249
]
} |
affinities for a number of angiotensin-related peptides calculated from competitive binding curves were in the order 125i-angiotensin ii = angiotensin ii greater than angiotensin iii greater than [ sar1 , ile8 ] angiotensin ii greater than [ sar1 , gly8 ] angiotensin ii . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
27,
38
]
} | {
"id": "C0003012",
"name": "angiotensin iii",
"pos": [
167,
182
]
} |
affinities for a number of angiotensin-related peptides calculated from competitive binding curves were in the order 125i-angiotensin ii = angiotensin ii greater than angiotensin iii greater than [ sar1 , ile8 ] angiotensin ii greater than [ sar1 , gly8 ] angiotensin ii . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
27,
38
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
256,
270
]
} |
the major form irreversibly reduced 5 alpha- and 5 beta-dihydrotestosterones , menadione and lauryl aldehyde with low km values of 10-70 microm , whereas the minor form not only reduced 17-oxosteroids , of which 3 alpha-hydroxy-5 beta-androstan-17-one was the best substrate , but also oxidized 17-hydroxysteroids in the... | NA | {
"id": "C0000167",
"name": "17-oxosteroids",
"pos": [
186,
200
]
} | {
"id": "C0015124",
"name": "3 alpha-hydroxy-5 beta-androstan-17-one",
"pos": [
212,
251
]
} |
the phorbol ester 12-o-tetradecanoyl-phorbol 13-acetate ( tpa ) , which is known to activate protein kinase c , a ca2+-regulated enzyme , also inhibited the association of egf with acini . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol 13-acetate",
"pos": [
18,
55
]
} |
corticosteroids increased the rate of pi efflux , although the loss rate partially declined towards the control value with prolonged exposure to the hormones . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
0,
15
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
149,
157
]
} |
the removal of cytosolic-type aldehyde dehydrogenase from preparations of sheep liver mitochondrial aldehyde dehydrogenase and the unusual properties of the purified mitochondrial enzyme in assays . | NA | {
"id": "C0001985",
"name": "aldehyde dehydrogenase",
"pos": [
30,
52
]
} | {
"id": "C2827577",
"name": "mitochondrial aldehyde dehydrogenase",
"pos": [
86,
122
]
} |
mitochondrial enzyme that had been purified to remove pi approximately 5.2 isoenzymes shows concentration-dependent lag phases in assays . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
14,
20
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
75,
85
]
} |
regulatory proteins , troponin and tropomyosin , and other myofibrillar proteins , such as m- and c-proteins , showed specific isoforms in type-i and type-ii fibres . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
11,
19
]
} | {
"id": "C0597298",
"name": "isoforms",
"pos": [
127,
135
]
} |
this collagen is similar to short-chain collagens synthesized by chick-embryo tibiotarsus , rabbit growth-plate cartilage and chick chondrocytes grown in three-dimensional gels . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
5,
13
]
} | {
"id": "C0969670",
"name": "short-chain collagens",
"pos": [
28,
49
]
} |
choline-depleted cells that were exposed to [ 3h ] choline contained [ 3h ] cdp-choline as the principal water-soluble choline derivative . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
0,
7
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
76,
87
]
} |
as the extracellular concentration of choline was increase , however , the amount of 3h in phosphocholine greatly exceeded that in all other water-soluble derivatives . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
38,
45
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
91,
105
]
} |
treatment with alpha-difluoromethylornithine decreased putrescine and spermidine contents by more than 98 % and that of spermine by 60 % , but cells exposed to exogenous polyamines did not require complete replenishment of the polyamine pools to resume growth . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
55,
65
]
} | {
"id": "C0037871",
"name": "contents",
"pos": [
81,
89
]
} |
treatment with alpha-difluoromethylornithine decreased putrescine and spermidine contents by more than 98 % and that of spermine by 60 % , but cells exposed to exogenous polyamines did not require complete replenishment of the polyamine pools to resume growth . | NA | {
"id": "C0037871",
"name": "contents",
"pos": [
81,
89
]
} | {
"id": "C0037874",
"name": "spermine",
"pos": [
120,
128
]
} |
in fact , a virtually normal growth rate was obtained in cells lacking putrescine , having 2 % of normal spermidine content and 156 % of normal spermine . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
71,
81
]
} | {
"id": "C0037871",
"name": "content",
"pos": [
116,
123
]
} |
these results suggest that the well-known increase in putrescine and spermidine in cells stimulated for growth is not essential for this to occur and that mammalian cells can utilize spermine as their only polyamine . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
54,
64
]
} | {
"id": "C0037871",
"name": "cells",
"pos": [
165,
170
]
} |
these results suggest that the well-known increase in putrescine and spermidine in cells stimulated for growth is not essential for this to occur and that mammalian cells can utilize spermine as their only polyamine . | NA | {
"id": "C0037871",
"name": "cells",
"pos": [
83,
88
]
} | {
"id": "C0037874",
"name": "only",
"pos": [
201,
205
]
} |
a substantial reversal of the growth-inhibitory effect of alpha-difluoromethylornithine was produced by a number of polyamines not normally found in mammalian cells , including the spermidine analogues aminopropylcadaverine and sym-homospermidine , which were partially converted into their respective spermine analogues... | NA | {
"id": "C0037871",
"name": "analogues",
"pos": [
192,
201
]
} | {
"id": "C0037874",
"name": "analogues",
"pos": [
311,
320
]
} |
rabbit iris smooth muscle was prelabelled with myo- [ 3h ] inositol for 90 min and the effect of carbachol on the accumulation of inositol phosphates from phosphatidylinositol 4,5-bisphosphate [ ptdins ( 4,5 ) p2 ] , phosphatidylinositol 4-phosphate ( ptdins4p ) and phosphatidylinositol ( ptdins ) was monitored with an... | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
59,
67
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
130,
149
]
} |
the data presented demonstrate that , in the iris , carbachol ( 50 microm ) stimulates the rapid breakdown of ptdins ( 4,5 ) p2 into [ 3h ] inositol trisphosphate ( insp3 ) and diacylglycerol , measured as phosphatidate , and that the accumulation of insp3 precedes that of [ 3h ] inositol bisphosphate ( insp2 ) and [ 3... | NA | {
"id": "C0021549",
"name": "insp3",
"pos": [
165,
170
]
} | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
324,
342
]
} |
the data presented demonstrate that , in the iris , carbachol ( 50 microm ) stimulates the rapid breakdown of ptdins ( 4,5 ) p2 into [ 3h ] inositol trisphosphate ( insp3 ) and diacylglycerol , measured as phosphatidate , and that the accumulation of insp3 precedes that of [ 3h ] inositol bisphosphate ( insp2 ) and [ 3... | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
140,
148
]
} | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
324,
342
]
} |
dose-response studies revealed that 5 microm-carbachol significantly increased ( 16 % ) the accumulation of insp3 whereas a significant increase in accumulation of insp2 and insp was observed only at agonist concentrations greater than 10 microm . | NA | {
"id": "C0021549",
"name": "insp3",
"pos": [
108,
113
]
} | {
"id": "C0021554",
"name": "insp",
"pos": [
174,
178
]
} |
the presence of 0.5 mm-acetoacetate in the medium significantly increased the specific activity of 3-oxoacid coa-transferase in neuroblastoma cells during the early exponential growth phase . | NA | {
"id": "C0000988",
"name": "acetoacetate",
"pos": [
23,
35
]
} | {
"id": "C0022618",
"name": "oxoacid",
"pos": [
101,
108
]
} |
although two preparations of pituitary bgh stimulated a significant ( p less than 0.01 ) increase in glycerol production , neither rebgh nor recombinant-dna-derived chicken gh was lipolytic . | NA | {
"id": "C0012931",
"name": "rebgh",
"pos": [
131,
136
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
153,
156
]
} |
the report of a recent fatality due to agranulocytosis provoked an examination of the plausible mechanisms of neutropenia and agranulocytosis . | NA | {
"id": "C0023530",
"name": "neutropenia",
"pos": [
110,
121
]
} | {
"id": "C0001824",
"name": "agranulocytosis",
"pos": [
126,
141
]
} |
such metabolites have not been reported earlier in connection with beta oxidation of prostaglandins or prostaglandin analogs . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
85,
99
]
} | {
"id": "C0033568",
"name": "prostaglandin analogs",
"pos": [
103,
124
]
} |
these results indicated that alcoholic liver cirrhosis presented a more deranged plasma amino acid pattern than nonalcoholic , and the amino acid imbalances , except for depressed bcaa and elevated proline , were derived , in part , from the hyperglucagonemia . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
88,
98
]
} | {
"id": "C0002521",
"name": "bcaa",
"pos": [
180,
184
]
} |
significant elevation of glutamic acid and glutamine concentrations in csf was observed in hepatic encephalopathic patients with fulminant hepatitis and liver cirrhosis . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
25,
38
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
43,
52
]
} |
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