text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
since m phi-sf appears to be modified sirs , oxidized by peroxide , and not a distinct second mediator produced by m phi in response to sirs , we propose eliminating the term m phi-sf and using sirsox to denote the active form of sirs produced either by the sirs-h2o2 reaction or sirs-treated m phi . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
57,
65
]
} | {
"id": "C0020281",
"name": "h2o2",
"pos": [
263,
267
]
} |
the distribution of peripheral blood t cells bearing fc receptors for igg ( t gamma ) and igm ( t mu ) was determined in 18 patients with cutaneous t-cell lymphoma ( sezary syndrome , mycosis fungoides ) and 15 normal controls . | NA | {
"id": "C0079773",
"name": "cutaneous t-cell",
"pos": [
138,
154
]
} | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
166,
181
]
} |
gentamicin-ticarcillin synergy in these infections is due , in part , to antimicrobial suppression of slowly growing aminoglycoside-resistant subpopulations of bacteria . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
0,
10
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
117,
131
]
} |
gentamicin-ticarcillin synergy in these infections is due , in part , to antimicrobial suppression of slowly growing aminoglycoside-resistant subpopulations of bacteria . | NA | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
73,
86
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
117,
131
]
} |
in mononuclear cells ( pbmc ) of healthy donors the enzyme level was remarkably constant , but in the cells of about 85 % of patients with viral infections enzyme activity was significantly elevated . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
23,
27
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
102,
107
]
} |
synthetase activity could be also detected in granulocytes , although normally its level in these cells was considerably lower than in pbmc . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
98,
103
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
135,
139
]
} |
after administration of ds and uk , improvement of clinical findings such as a fall of bp , disappearance of edema , reduction in urine protein , and increase in ccr were observed . | NA | {
"id": "C0037088",
"name": "clinical findings",
"pos": [
51,
68
]
} | {
"id": "C0013604",
"name": "edema",
"pos": [
109,
114
]
} |
concentrations of estradiol ( e2 ) , progesterone ( p ) , 17-hydroxyprogesterone ( 17-ohp ) , hcg and hpl were measured by radioimmunoassay in sera obtained serially from 35 subjects who received artificial termination of pregnancy and 24 of them were administered 10,000 iu of hcg 3 to 5 days later when endogenous hcg ... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
37,
49
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
58,
80
]
} |
an attempt was made in vitro and in vivo to clarify the significance of aminoglycoside-resistant subpopulations that can be isolated from gentamicin-susceptible pseudomonas aeruginosa . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
72,
86
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
138,
148
]
} |
the apoc-iii/c-ii ratio in very low density lipoproteins ( vldl ) and in the lighter hdl subfraction ( hdl2 ) was lower indicating net lipoprotein enrichment with apoc-ii than with apoc-iii ; | NA | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
27,
56
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
135,
146
]
} |
isocaloric changes in dietary carbohydrate and fat cause significant alterations in plasma levels of vldl and hdl 2 , the two major lipoproteins that transport apoc-iii and apoc-ii . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
101,
105
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
132,
144
]
} |
to permit separation of the hdl ( 1 ) from vldl , ldl , and lp ( a ) , the apob-containing lipoproteins were first precipitated from serum using the phosphotungstic acid/magnesium chloride ( pta/mgcl ( 2 ) ) method after which the supernatant fraction was subjected to zonal ultracentrifugation . | NA | {
"id": "C0065058",
"name": "lp ( a",
"pos": [
60,
66
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
91,
103
]
} |
variant lipoproteins vhdl ( a species with density greater than that of hdl ( 3 ) ) , mdl ( a species , most likely lp ( a ) , with density intermediate between that of hdl and ldl ) , and idl are subsequently quantitated by a method combining difference calculations with curve shapes . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
8,
20
]
} | {
"id": "C0065058",
"name": "lp ( a",
"pos": [
116,
122
]
} |
dihydroxypropyl theophylline ( dyphylline ) was administered by aerosol in a single dose of 250 mg aerosolized over five minutes to two asthmatic volunteers and in a single dose of 375 mg aerosolized over ten minutes to two other asthmatic volunteers . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
16,
28
]
} | {
"id": "C0013360",
"name": "dyphylline",
"pos": [
31,
41
]
} |
to determine whether the plasma ferritin assay reliably reflects body iron stores , as determined by the presence of stainable iron in the marrow , 63 iron-deficient patients were serially studied after receiving a total dose infusion of iron dextran ( imferon ) . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
70,
74
]
} | {
"id": "C0022092",
"name": "iron dextran",
"pos": [
238,
250
]
} |
the frequencies of precursors of c57bl/6 t lymphocytes that respond to dba/2 alloantigens by secreting the lymphokines interleukin 2 ( il-2 ) , macrophage-activating factor ( maf ) , and granulocyte-macrophage colony-stimulating factor ( gm-csf ) have been directly compared with cytolytic t lymphocyte precursor ( ctl-p... | NA | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
107,
118
]
} | {
"id": "C0079786",
"name": "macrophage-activating factor",
"pos": [
144,
172
]
} |
bone samples from the iliac crest were taken from 20 subjects and the content of some trace elements ( iron , zinc , selenium , cobalt , strontium , aluminium , scandium , rubidium and fluorine ) and of the matrix elements calcium , phosphorus and sodium was determined . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
92,
100
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
233,
243
]
} |
antigenic analysis of a recombinant virus by neuraminidase-inhibition tests with specific antisera to the isolated neuraminidases of a/victoria/3/75 and a/aichi/2/68 revealed that the neuraminidase antigen of the recombinant virus , a/swine/kanagawa/2/78 ( h1n2 ) , was closely related to those of a/tokyo/6/73 ( h3n2 ) ... | NA | {
"id": "C0003342",
"name": "antigenic",
"pos": [
0,
9
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
198,
205
]
} |
a remarkable low level of dopamine and a high level of homovanillic acid measured indicate this case would have had an increased turnover rate of dopamine in the dopaminergic nerve terminals . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
26,
34
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
162,
174
]
} |
adrenergic amines ( dopamine [ da ] , norepinephrine [ ne ] , epinephrine [ e ] and related compounds ( dopa , 3-methoxytyramine [ mt ] , normetanephrine [ nmn ] , metanephrine [ mn ] , 3-5-dihydroxyphenylacetic acid [ dopac ] , vanilmandelic acid [ vma ] were analyzed in urine of human from one day to 40 years of age ... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
38,
52
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
62,
73
]
} |
adrenergic amines ( dopamine [ da ] , norepinephrine [ ne ] , epinephrine [ e ] and related compounds ( dopa , 3-methoxytyramine [ mt ] , normetanephrine [ nmn ] , metanephrine [ mn ] , 3-5-dihydroxyphenylacetic acid [ dopac ] , vanilmandelic acid [ vma ] were analyzed in urine of human from one day to 40 years of age ... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
38,
52
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
138,
153
]
} |
adrenergic amines ( dopamine [ da ] , norepinephrine [ ne ] , epinephrine [ e ] and related compounds ( dopa , 3-methoxytyramine [ mt ] , normetanephrine [ nmn ] , metanephrine [ mn ] , 3-5-dihydroxyphenylacetic acid [ dopac ] , vanilmandelic acid [ vma ] were analyzed in urine of human from one day to 40 years of age ... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
41,
52
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
164,
176
]
} |
in neonatal life ( 1 day to 3.5 months ) , the total amounts of urinary ( e + mn ) and ( ne + nmn + vma ) were lower in girls than in boys , the former two compounds being mainly of adrenal medullary origin and the latter three coming largely from the sympathetic neurons . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
3,
5
]
} | {
"id": "C0028385",
"name": "nmn",
"pos": [
94,
97
]
} |
in adulthood , women excreted epinephrine ( 12.5 +/- 2.2 micrograms/24 hours ) at lower levels then men ( 22.8 +/- 4.5 micrograms/24 hours ) but no sex related differences occurred in the total amounts of urinary e + mn and ne + nmn + vma . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
30,
41
]
} | {
"id": "C0025562",
"name": "mn",
"pos": [
230,
232
]
} |
in adulthood , women excreted epinephrine ( 12.5 +/- 2.2 micrograms/24 hours ) at lower levels then men ( 22.8 +/- 4.5 micrograms/24 hours ) but no sex related differences occurred in the total amounts of urinary e + mn and ne + nmn + vma . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
30,
41
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
224,
226
]
} |
in adulthood , women excreted epinephrine ( 12.5 +/- 2.2 micrograms/24 hours ) at lower levels then men ( 22.8 +/- 4.5 micrograms/24 hours ) but no sex related differences occurred in the total amounts of urinary e + mn and ne + nmn + vma . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
33,
35
]
} | {
"id": "C0028385",
"name": "nmn",
"pos": [
229,
232
]
} |
excitatory effects of kynurenine and its metabolites , amino acids and convulsants administered into brain ventricles : differences between rats and mice . | NA | {
"id": "C0022818",
"name": "kynurenine",
"pos": [
22,
32
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
55,
66
]
} |
when introduced intracerebroventricularly , quinolinic acid appeared to be the only kynurenine metabolite among those tested ( l- and dl-kynurenine sulfate , kynurenic and nicotinic acids , nicotinamide ) which induced locomotor excitement and clonic seizures in rats ; | NA | {
"id": "C0028049",
"name": "nicotinic acids",
"pos": [
172,
187
]
} | {
"id": "C0027996",
"name": "nicotinamide",
"pos": [
190,
202
]
} |
neither the excitatory amino acids , l-glutamic and l-aspartic acids nor the inhibitory amino acids , gaba , glycine and taurine induced excitement or seizures in rats but did in mice . | NA | {
"id": "C0243046",
"name": "excitatory",
"pos": [
12,
22
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
88,
99
]
} |
neither the excitatory amino acids , l-glutamic and l-aspartic acids nor the inhibitory amino acids , gaba , glycine and taurine induced excitement or seizures in rats but did in mice . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
23,
34
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
109,
116
]
} |
thus mice may be preferable for studies of this type on excitatory amino acids ( including kynurenine pathway metabolites ) and rats for those on inhibitory amino acids . | NA | {
"id": "C0243046",
"name": "excitatory",
"pos": [
56,
66
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
157,
168
]
} |
thus mice may be preferable for studies of this type on excitatory amino acids ( including kynurenine pathway metabolites ) and rats for those on inhibitory amino acids . | NA | {
"id": "C0022818",
"name": "kynurenine",
"pos": [
91,
101
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
157,
168
]
} |
dibutyryl camp appears to stimulate dopamine metabolism within dopaminergic nerve endings but does not stimulate dopamine release . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
63,
75
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
113,
121
]
} |
we studied the action of the following phosphodiesterase inhibitors ( pdeis ) : rolipram ( 4- [ 3-cyclopentoxy-5-methoxyphenyl ] -2-pyrrolidione ) , ro 20-1724 ( 4- [ 3-butoxy-4-methoxybenzyl ] -2-imidazolidione ) , 1-methyl-3-isobutylxanthine ( imbx ) and theophylline on flexor reflex activity of the hind limb in the ... | NA | {
"id": "C0000096",
"name": "1-methyl-3-isobutylxanthine",
"pos": [
216,
243
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
257,
269
]
} |
all the inhibitors potentiated flexor reflex activity in a dose-dependent manner in the following order of potency : rolipram greater than ro 20-1724 greater than ibmx greater than theophylline . | NA | {
"id": "C0000096",
"name": "ibmx",
"pos": [
163,
167
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
181,
193
]
} |
the finding that carbonic anhydrase ( ca ) inhibitors have no effect on the tet-induced structural changes indicates that the swelling we observe is not related to a ca-dependent process . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
4,
11
]
} | {
"id": "C0013604",
"name": "swelling",
"pos": [
126,
134
]
} |
vitamin d-deficient fish showed no change in bone ash but exhibited clinical manifestations of tetany with no hypocalcemia . | NA | {
"id": "C0039621",
"name": "tetany",
"pos": [
95,
101
]
} | {
"id": "C0020598",
"name": "hypocalcemia",
"pos": [
110,
122
]
} |
the ratios of plasma valtine : glycine and indispensable : dispensable amino acids were affected by nitrogen intake as well as by uremia , whereas plasma citrulline : tryptophan was influenced only by the uremic state . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
31,
38
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
71,
82
]
} |
this elevation in total niacin was mainly due to increases in niacin ( 14 times ) and niacinamide nucleotides ( 2 times ) . | NA | {
"id": "C0027996",
"name": "niacin",
"pos": [
24,
30
]
} | {
"id": "C0028027",
"name": "niacinamide",
"pos": [
86,
97
]
} |
in the presence of atp and mn2+ , enzyme-bound hydroxocobalamin , cyanocobalamin and methylcobalamin were rapidly displaced by added adenosylcobalamin . | NA | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
47,
63
]
} | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
66,
80
]
} |
when the glycerol-inactivated holoenzymes in situ were dialyzed against a buffer containing atp and mg2+ , the inactivated coenzyme moiety dissociated from the enzymes leaving apoproteins . | NA | {
"id": "C0282109",
"name": "holoenzymes",
"pos": [
30,
41
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
160,
167
]
} |
a band phagocytosis , following z line and i band loss , is described in polymyositis , in epsilon amino caproic acid induced myopathy and in an experimental myositis of guinea pigs . | NA | {
"id": "C0026848",
"name": "myopathy",
"pos": [
126,
134
]
} | {
"id": "C0027121",
"name": "myositis",
"pos": [
158,
166
]
} |
interstitial edema and focal nephritis was prominent in both groups , a finding which minimises their role in the pathogenesis of renal failure in experimental leptospirosis . | NA | {
"id": "C0013604",
"name": "interstitial edema",
"pos": [
0,
18
]
} | {
"id": "C0037088",
"name": "finding",
"pos": [
72,
79
]
} |
the chemotherapeutic action of 5-fluorouracil ( 5-fu ) monotherapy on l-1210 leukemia in mice was compared with combinations of pyrimidines ( uracil , uridine , deoxyuridine , cytosine , cytidine , deoxycytidine , thymine and thymidine ) or purines ( adenine , adenosine , deoxyadenosine , guanine , guanosine , deoxygua... | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
39,
45
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
214,
221
]
} |
the chemotherapeutic action of 5-fluorouracil ( 5-fu ) monotherapy on l-1210 leukemia in mice was compared with combinations of pyrimidines ( uracil , uridine , deoxyuridine , cytosine , cytidine , deoxycytidine , thymine and thymidine ) or purines ( adenine , adenosine , deoxyadenosine , guanine , guanosine , deoxygua... | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
39,
45
]
} | {
"id": "C0016360",
"name": "5-fu",
"pos": [
346,
350
]
} |
the chemotherapeutic action of 5-fluorouracil ( 5-fu ) monotherapy on l-1210 leukemia in mice was compared with combinations of pyrimidines ( uracil , uridine , deoxyuridine , cytosine , cytidine , deoxycytidine , thymine and thymidine ) or purines ( adenine , adenosine , deoxyadenosine , guanine , guanosine , deoxygua... | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
187,
195
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
198,
211
]
} |
the chemotherapeutic action of 5-fluorouracil ( 5-fu ) monotherapy on l-1210 leukemia in mice was compared with combinations of pyrimidines ( uracil , uridine , deoxyuridine , cytosine , cytidine , deoxycytidine , thymine and thymidine ) or purines ( adenine , adenosine , deoxyadenosine , guanine , guanosine , deoxygua... | NA | {
"id": "C0034140",
"name": "purines",
"pos": [
241,
248
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
251,
258
]
} |
the antitumor activity of 5-fu was enhanced by coadministration of uracil , thymine or guanosine , but the toxicity of the first two compounds was also enhanced . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
28,
30
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
67,
73
]
} |
the antitumor activity of 5-fu was enhanced by coadministration of uracil , thymine or guanosine , but the toxicity of the first two compounds was also enhanced . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
67,
73
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
76,
83
]
} |
125i-labelled proteins ( albumin and fibrinogen ) were encapsulated under similar conditions to determine the efficiency of the microencapsulation process . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
14,
22
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
25,
32
]
} |
the interaction of 39 drugs and model compounds of diverse chemical structure with povidone and crospovidone was studied . | NA | {
"id": "C0032856",
"name": "povidone",
"pos": [
83,
91
]
} | {
"id": "C0728803",
"name": "crospovidone",
"pos": [
96,
108
]
} |
( - ) -baclofen depressed the amplitude of the extracellular excitatory postsynaptic potential with an ic50 of 3.7 microm and was 180 times more potent than ( + ) -baclofen . gamma-aminobutyric acid , 3-aminopropanesulfonic acid and imidazole-4-acetic acid also inhibited transmission at this site . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
7,
15
]
} | {
"id": "C0016904",
"name": "gamma-aminobutyric acid",
"pos": [
175,
198
]
} |
inhibition of gentamicin uptake in rat renal cortex in vivo by aminoglycosides and organic polycations . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
14,
24
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
63,
78
]
} |
conh was about equally effective in reducing brain norepinephrine and epi concentrations in both animal strains , but conh was more effective in elevating brain dopamine and 3,4-dihydroxyphenylacetic acid concentrations in shr than in wky . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
51,
65
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
70,
73
]
} |
the results of this study suggest that brain epi-containing neurons may be directly involved in the regulation of blood pressure or alternatively they may indirectly control cardiovascular function by modulating brain norepinephrine- and/or dopamine-neuronal activity . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
45,
48
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
218,
232
]
} |
nisoldipine is a new dihydropyridine derivative which is structurally related to the calcium current blocker nifedipine . | NA | {
"id": "C0028116",
"name": "nisoldipine",
"pos": [
0,
11
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
21,
36
]
} |
nisoldipine is a new dihydropyridine derivative which is structurally related to the calcium current blocker nifedipine . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
21,
36
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
109,
119
]
} |
a hypothesis that this enhancement is due to a stimulation of the glycoside binding to sarcolemmal na+ , k+-adenosine triphosphatase ( atpase ) caused by an increase in intracellular na+ available to the sodium pump was tested in isolated left atrial muscle preparations of guinea-pig heart , incubated at 30 degrees c a... | NA | {
"id": "C0001479",
"name": "na",
"pos": [
99,
101
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
135,
141
]
} |
morphine and the opioid peptides [ d-ala2 , d-leu5 ] -enkephalin ( dadl ) , beta-endorphin and tyr-d-ser-gly-phe-leu-thr ( a delta agonist ) caused a concentration-dependent shift to the left in the input-output curve constructed by plotting population spike amplitude ( a measure of evoked firing ) as a function of the... | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
17,
32
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
54,
64
]
} |
these findings suggest different effects on membrane matrix lipids than on boundary lipids adjacent to the enzyme . | NA | {
"id": "C0025249",
"name": "membrane",
"pos": [
44,
52
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
84,
90
]
} |
vagal stimulation applied during periods of high-rate ventricular tachycardia reduced sinus , atrioventricular nodal and ventricular ectopic beats , with no uncoupled ectopic beats seen during stimulation . | NA | {
"id": "C0151636",
"name": "ventricular ectopic beats",
"pos": [
121,
146
]
} | {
"id": "C0340464",
"name": "ectopic",
"pos": [
167,
174
]
} |
on the fetal side the maximal uptake ( u ( max ) ) determined at tracer concentrations was high for the short-chain neutral amino acid alanine ( 76 % ) and the long-chain neutrals , leucine ( 75 % ) , phenylalanine ( 90 % ) and tyrosine ( 82 % ) and for the basic amino acid lysine ( 65 % ) . | NA | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
258,
274
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
275,
281
]
} |
the uptake of alanine and phenylalanine on the fetal side was inhibited by both short-chain ( alanine , serine , cysteine ) and long-chain ( phenylalanine , methionine , leucine ) neutral amino acids . d-alanine had no effect on l-alanine uptake whereas d-phenylalanine significantly inhibited that of l-phenylalanine . | NA | {
"id": "C0036720",
"name": "serine",
"pos": [
104,
110
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
180,
199
]
} |
the uptake of alanine and phenylalanine on the fetal side was inhibited by both short-chain ( alanine , serine , cysteine ) and long-chain ( phenylalanine , methionine , leucine ) neutral amino acids . d-alanine had no effect on l-alanine uptake whereas d-phenylalanine significantly inhibited that of l-phenylalanine . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
113,
121
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
180,
199
]
} |
unlike alpha-receptors , the receptors on the rat basilar artery were activated equally well by dopamine , adrenaline , and both optical isomers of noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
107,
117
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
148,
161
]
} |
lipolytic activity of pregastric and gastric secretions and extracts of the gastric wall of weaned and non weaned rabbit was measured in vitro on several substrates : lipids from rabbit and cow milk or from several lipid emulsions ( triglycerides containing 3 identical chains , medium or long ; coconut or sunflower oil... | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
167,
172
]
} | {
"id": "C0015677",
"name": "fats",
"pos": [
323,
327
]
} |
plasma epinephrine , norepinephrine and substrate concentrations ( glycemia , free fatty acids ( ffa ) , lactic acid ) have been compared in same dogs exposed to cold then made to perform a running test . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
7,
18
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
21,
35
]
} |
however plasma epinephrine and norepinephrine concentrations were respectively 2,5 and 3 times higher during cold exposure than they were during muscular exercise . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
15,
26
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
31,
45
]
} |
a series of 26 cases of injury to the extracranial carotid artery included 3 patients with false aneurysms , 21 dissecting aneurysms , and 3 aneurysms following direct trauma . | NA | {
"id": "C1510412",
"name": "false aneurysms",
"pos": [
91,
106
]
} | {
"id": "C0002940",
"name": "aneurysms",
"pos": [
141,
150
]
} |
polyarthritis is only induced in conjunction with certain ( oily ) lipids = coarthritogens : some of these lipids are present in/on skin , intestines , etc . | NA | {
"id": "C0028908",
"name": "oily",
"pos": [
60,
64
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
107,
113
]
} |
plasma and erythrocyte gold concentrations were measured in 35 patients taking gold sodium thiomalate ( gstm ) for rheumatoid arthritis . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
23,
27
]
} | {
"id": "C0018034",
"name": "gold sodium thiomalate",
"pos": [
79,
101
]
} |
a prospective study on 15 patients commencing treatment with gstm showed that the higher concentrations of erythrocyte gold seen in smokers were achieved within the first 2 weeks of treatment . | NA | {
"id": "C0018034",
"name": "gstm",
"pos": [
61,
65
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
119,
123
]
} |
auranofin ( af ) , a new gold compound , has been suggested as an alternative to parenteral gold in the treatment of rheumatoid arthritis ( ra ) . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
0,
9
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
92,
96
]
} |
af also suppressed '7s ' hemagglutinin antibody response to sheep red blood cells in adjuvant arthritic rats , whereas neither gstm nor gold sodium thioglucose significantly suppressed hemagglutinin antibody titers at doses which produced antiinflammatory activity . | NA | {
"id": "C0004320",
"name": "af",
"pos": [
0,
2
]
} | {
"id": "C0018033",
"name": "gold",
"pos": [
136,
140
]
} |
auranofin ( af ) differs significantly from gold sodium thiomalate ( gstm ) in formulation , i.e. , aurous gold is stabilized by dual sulfur and phosphorus ligands , hydrophobic rather than hydrophilic characteristics , and lack of ionic charge . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
0,
9
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
107,
111
]
} |
auranofin ( af ) differs significantly from gold sodium thiomalate ( gstm ) in formulation , i.e. , aurous gold is stabilized by dual sulfur and phosphorus ligands , hydrophobic rather than hydrophilic characteristics , and lack of ionic charge . | NA | {
"id": "C0018034",
"name": "gold sodium thiomalate",
"pos": [
44,
66
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
107,
111
]
} |
these attributes facilitate : oral absorption of af , plasma membrane penetration , increase in intracellular lymphocyte gold concentration ; | NA | {
"id": "C0004320",
"name": "af",
"pos": [
49,
51
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
121,
125
]
} |
in further contrast to gstm , af gold is orally absorbed , exhibits protracted blood levels , is bound to cellular elements of the blood , excreted mainly in the feces , and exhibits less tissue retention . | NA | {
"id": "C0018034",
"name": "gstm",
"pos": [
23,
27
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
33,
37
]
} |
in further contrast to gstm , af gold is orally absorbed , exhibits protracted blood levels , is bound to cellular elements of the blood , excreted mainly in the feces , and exhibits less tissue retention . | NA | {
"id": "C0004320",
"name": "af",
"pos": [
30,
32
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
33,
37
]
} |
with gstm and gk there were no measurable amounts of gold in the red cell lysate or erythrocyte membranes whereas with af 40 % of gold was localized within erythrocytes . | NA | {
"id": "C0004320",
"name": "af",
"pos": [
119,
121
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
130,
134
]
} |
the amount of gold in granulocytes and mononuclear cells after incubation with af is considerably higher than with gk and gstm . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
14,
18
]
} | {
"id": "C0004320",
"name": "af",
"pos": [
79,
81
]
} |
gold from orally administered auranofin ( af ) was absorbed 17-23 % in rats and 15-38 % in dogs . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
0,
4
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
30,
39
]
} |
evidence indicated that af was rapidly degraded to triethylphosphine oxide with the remaining molecular fragments postulated to be a protein-gold complex and acetylthioglucose . | NA | {
"id": "C0004320",
"name": "af",
"pos": [
24,
26
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
141,
145
]
} |
nearly 70 % of parenteral gold is excreted in the urine and 30 % in feces , while only 5 % of af is in urine and 95 % in feces . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
26,
30
]
} | {
"id": "C0004320",
"name": "af",
"pos": [
94,
96
]
} |
the amount of gold retained following intravenous 195au-labelled gold sodium thiomalate is 43 % at 60 days and 25 % at 250 days , but only 15 % with oral radiolabeled af 10 days after ingestion . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
14,
18
]
} | {
"id": "C0018034",
"name": "gold sodium thiomalate",
"pos": [
65,
87
]
} |
the amount of gold retained following intravenous 195au-labelled gold sodium thiomalate is 43 % at 60 days and 25 % at 250 days , but only 15 % with oral radiolabeled af 10 days after ingestion . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
14,
18
]
} | {
"id": "C0004320",
"name": "af",
"pos": [
178,
180
]
} |
mouse amniotic fluid ( af ) strongly inhibited the in vitro generation of cell mediated cytolytic responses to allogeneic el4 tumor cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
47,
50
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
111,
121
]
} |
under normal ionic conditions dye transfer from an injected muscle cell to neighboring muscle cells occurs rapidly ( in less than 6 sec ) while transfer to neighboring fibroblasts occurs more slowly . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
94,
99
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
168,
179
]
} |
significant group differentiation ( controls/headache prone ) was possible on the basis of auditory stimulus sensitivity , irrespective of current pain state . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
45,
53
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
147,
151
]
} |
rats were supplied with 25 kinds of food , which were divided into 5 classes of protein and 5 classes of fat content , to examine the effect of dietary protein and fat on the metabolism and retention of ddt in the liver . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
80,
87
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
144,
159
]
} |
alcoholic and nonalcoholic liver disease was still 100 % differentiable when equated for number of patients with cirrhosis , hepatitis , and hepatitis combined with cirrhosis or fibrosis . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
27,
40
]
} | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
141,
150
]
} |
alcoholic and nonalcoholic liver disease was still 100 % differentiable when equated for number of patients with cirrhosis , hepatitis , and hepatitis combined with cirrhosis or fibrosis . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
27,
40
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
165,
174
]
} |
in the 12 cases with significant stenosis due to atherosclerosis , only 4 patients received corticosteroid hormone for more than one year . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
92,
106
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
107,
114
]
} |
the underlying diseases in the 64 patients included in the evaluation of efficacy were acute myelocytic leukemia ( 30 cases ) , acute lymphocytic leukemia ( 9 ) , acute promyelocytic leukemia ( 3 ) , acute monocytic leukemia ( 2 ) , chronic myelocytic leukemia-blastic crisis ( 10 ) , erythroleukemia ( 2 ) , malignant l... | NA | {
"id": "C0023467",
"name": "acute",
"pos": [
87,
92
]
} | {
"id": "C0023487",
"name": "acute",
"pos": [
200,
205
]
} |
the underlying diseases in the 64 patients included in the evaluation of efficacy were acute myelocytic leukemia ( 30 cases ) , acute lymphocytic leukemia ( 9 ) , acute promyelocytic leukemia ( 3 ) , acute monocytic leukemia ( 2 ) , chronic myelocytic leukemia-blastic crisis ( 10 ) , erythroleukemia ( 2 ) , malignant l... | NA | {
"id": "C0023467",
"name": "acute",
"pos": [
87,
92
]
} | {
"id": "C0023465",
"name": "acute monocytic leukemia",
"pos": [
200,
224
]
} |
the tests for susceptibility of the strains to the 3 aminoglycosides ( gentamicin , tobramycin , amikacin ) and 3 tetracyclines ( tetracycline , doxycycline , minocycline ) were all performed by the serial 2-fold agar plate dilution method on heart infusion agar , standardized by the japan society of chemotherapy , usi... | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
53,
68
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
71,
81
]
} |
the tests for susceptibility of the strains to the 3 aminoglycosides ( gentamicin , tobramycin , amikacin ) and 3 tetracyclines ( tetracycline , doxycycline , minocycline ) were all performed by the serial 2-fold agar plate dilution method on heart infusion agar , standardized by the japan society of chemotherapy , usi... | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
114,
127
]
} | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
145,
156
]
} |
the tests for susceptibility of the strains to the 3 aminoglycosides ( gentamicin , tobramycin , amikacin ) and 3 tetracyclines ( tetracycline , doxycycline , minocycline ) were all performed by the serial 2-fold agar plate dilution method on heart infusion agar , standardized by the japan society of chemotherapy , usi... | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
114,
127
]
} | {
"id": "C0026187",
"name": "minocycline",
"pos": [
159,
170
]
} |
experimental and clinical studies were carried out on cefmetazole ( cmz ) , a synthetic antibiotic of cephamycin group , and the following results were obtained . | NA | {
"id": "C0007550",
"name": "cefmetazole",
"pos": [
54,
65
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
102,
112
]
} |
cephalosporins developed recently such as cefotaxime , cefoperazone , ceftizoxime , latamoxef etc . show very potent antimicrobial activity against gram-negative bacilli , but their activity against s. aureus and s. epidermidis is weaker than that of cefotiam , cephalothin , cefazolin etc . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
42,
52
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
70,
81
]
} |
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