text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the child was treated successfully with allopurinol , and a reduction in dietary purine but with only partial return of renal function . | NA | {
"id": "C0002144",
"name": "allopurinol",
"pos": [
40,
51
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
81,
87
]
} |
the urinary polyamines putrescine ( pu ) and spermidine ( spd ) were measured for 67 patients with lymphomas : 48 non-hodgkin ( nhl ) and 18 hodgkin 's disease ( hd ) . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
99,
108
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
128,
131
]
} |
the urinary polyamines putrescine ( pu ) and spermidine ( spd ) were measured for 67 patients with lymphomas : 48 non-hodgkin ( nhl ) and 18 hodgkin 's disease ( hd ) . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
99,
108
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
141,
159
]
} |
in 10 patients plasma levels of renin , noradrenaline , adrenaline and cholesterol were measured during placebo and after 3 months of therapy . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
40,
53
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
56,
66
]
} |
changes in plasma noradrenaline and adrenaline were small and not significant , but renin and cholesterol were significantly reduced . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
18,
31
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
36,
46
]
} |
plasma concentrations of noradrenaline and adrenaline were not influenced by amezinium during rest or tilt . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
25,
38
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
43,
53
]
} |
epileptic patients exhibited similar pb kinetics : disposition half-lives were 77 to 128 h , vss 0.61 +/- 0.05 l/kg , and cl 3.9 +/- 0.76 ml/h/kg . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
40,
48
]
} | {
"id": "C0018517",
"name": "half-lives",
"pos": [
63,
73
]
} |
the main pulmonary artery was found to be less sensitive to epinephrine , norepinephrine and phenylephrine than its left and right main branches . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
60,
71
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
74,
88
]
} |
the difference in sensitivity was larger for adrenergic agonists which are known to be taken up by adrenergic neurons ( epinephrine , norepinephrine , phenylephrine ) than for an agonist which is not taken up by these neurons ( methoxamine ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
120,
131
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
134,
148
]
} |
these results suggest an alpha 1-adrenoceptor may also mediate the central hypotensive action of clonidine , or possibly that the central alpha-adrenoceptors in which clonidine acts , may show pharmacological differences to peripheral alpha 1- and alpha 2-subtypes . | NA | {
"id": "C0001638",
"name": "alpha 1-adrenoceptor",
"pos": [
25,
45
]
} | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
138,
157
]
} |
the trained rats dose dependently generalized the effect of dl- , d- and l-skf 10,047 , as well as cyclazocine , phencyclidine and ketamine but did not generalize the effect of either fentanyl , morphine , bremazocine , ethylketocyclazocine , pentazocine , nalorphine , naloxone , mr 2266 , d-lysergic acid diethylamide ... | NA | {
"id": "C0010526",
"name": "cyclazocine",
"pos": [
99,
110
]
} | {
"id": "C0079314",
"name": "ethylketocyclazocine",
"pos": [
220,
240
]
} |
the values obtained for both types of muscle were similar to those obtained for [ 3h ] nitrendipine binding , as were the potencies of a series of dihydropyridines for competing with [ 3h ] nimodipine . | NA | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
87,
99
]
} | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
147,
163
]
} |
the values obtained for both types of muscle were similar to those obtained for [ 3h ] nitrendipine binding , as were the potencies of a series of dihydropyridines for competing with [ 3h ] nimodipine . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
147,
163
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
190,
200
]
} |
the effect of vasoactive intestinal polypeptide ( vip ) on in vitro acth release and adenylate cyclase activity was investigated in human acth-secreting pituitary adenomas from 4 patients with cushing 's disease and 2 patients with nelson 's syndrome . | NA | {
"id": "C1306214",
"name": "acth-secreting",
"pos": [
138,
152
]
} | {
"id": "C0027577",
"name": "nelson 's syndrome",
"pos": [
232,
250
]
} |
in initial studies conducted in the presence of uptake1 blocker desipramine ( 10 ( -6 ) m ) and uptake 2 blocker , normetanephrine ( 10 ( -5 ) m ) there was an apparent uncoupling of the influence of yohimbine on nerve-stimulated contractile response from norepinephrine overflow . | NA | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
115,
130
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
256,
270
]
} |
these results were found to be due to the electrolytic o-demethylation of normetanephrine with the resultant generation of large quantities of norepinephrine obscuring the influence of yohimbine on nerve-stimulated norepinephrine overflow from the vas deferens . | NA | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
74,
89
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
215,
229
]
} |
these findings serve as a warming to the use of normetanephrine as an uptake1 blocker when radioenzymatic assay is used to measure norepinephrine overflow from transmural-stimulated isolated tissue preparations . | NA | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
48,
63
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
131,
145
]
} |
glucose and low molecular weight dextrans inhibited the histamine release induced by high molecular weight dextrans but the inhibition could not be explained in terms of a simple competitive model . | NA | {
"id": "C0011793",
"name": "low molecular weight dextrans",
"pos": [
12,
41
]
} | {
"id": "C0011806",
"name": "dextrans",
"pos": [
107,
115
]
} |
the primordial stem cell for the osteoclast ( haematopoietic stem cell ? ) is thus not a cfus . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0018956",
"name": "haematopoietic stem cell",
"pos": [
46,
70
]
} |
the observations suggest that measurement can be used in clinical practice to diagnose the presence of asthma , to help assess the severity of asthma and , in the assessment of occupational asthma , to determine if exposure can heighten bronchial responsiveness . | NA | {
"id": "C0004096",
"name": "asthma",
"pos": [
103,
109
]
} | {
"id": "C0264423",
"name": "occupational asthma",
"pos": [
177,
196
]
} |
an analysis of a commercial sample of symphyti radix originating from poland with a total alkaloid content of 0.07 % revealed the presence of 7 pyrrolizidine alkaloid-n-oxides : 7-acetyl intermedine , 7-acetyl lycopsamine as the main constituents and lycopsamine , intermedine , symphytine and traces of 2 further not ye... | NA | {
"id": "C0034335",
"name": "pyrrolizidine",
"pos": [
144,
157
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
333,
342
]
} |
concurrent application of the subthreshold dose of enkephalins and morphine has revealed a possibility of the effects summation , the highest pharmacological activity being exhibited by leu-enkephalin combined with morphine . | NA | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
51,
62
]
} | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
186,
200
]
} |
administration of cholestyramine changed both the concentration and the ratio of lipid components in all the classes of lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
81,
86
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
120,
132
]
} |
the paper concerns changes in the activity of some enzymes of azurophil granules of mouse neutrophils under a single administration of the bacterial polysaccharide prodigiosan and the synthetic anabolic hormone retabolil . | NA | {
"id": "C0032595",
"name": "bacterial",
"pos": [
139,
148
]
} | {
"id": "C0033260",
"name": "prodigiosan",
"pos": [
164,
175
]
} |
( 5 ) the endorphins are endogeneous opiate peptides and are derived from a common acth/ beta-lipotropin precursor . | NA | {
"id": "C0014242",
"name": "endorphins",
"pos": [
10,
20
]
} | {
"id": "C0205753",
"name": "opiate peptides",
"pos": [
37,
52
]
} |
subclinical infections with chlamydia trachomatitis may be a major cause of tubal infertility in the united states , and chlamydial serologic studies may be useful in identifying the subset of infertile women likely to have tubal factor . | NA | {
"id": "C0021359",
"name": "infertility",
"pos": [
82,
93
]
} | {
"id": "C0021361",
"name": "infertile women",
"pos": [
193,
208
]
} |
serum high-density lipoprotein ( hdl ) cholesterol , low density lipoprotein ( ldl ) cholesterol , triglyceride , and cholesterol were measured prior to the initiation of oc therapy and were repeated after treatment cycles 2 and 4 . | NA | {
"id": "C0023824",
"name": "low density lipoprotein",
"pos": [
53,
76
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
118,
129
]
} |
in order to examine whether somatostatin-28 originally isolated from porcine and ovine tissues was present in the human gut and pancreas or not , immunohistochemical methods using specific antisera against somatostatin-28 and somatostatin-14 antisera were carried out in the fetal and adult human gut and pancreas . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
28,
43
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
226,
241
]
} |
the specific antisera against somatostatin-28 were prepared from somatostatin-28 antisera by absorption of somatostatin-28 antisera with sepharose 4b-somatostatin-14 . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
30,
45
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
150,
165
]
} |
although detection of somatostatin-28 like immunoreactivity was not inhibited in the sections in which specific antisera against somatostatin-28 pretreated with either somatostatin-14 or other kinds of peptide hormones were employed to replace primary antisera in the immunohistochemical staining process , it was comple... | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
168,
183
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
408,
423
]
} |
although the finding seemed to imply that full sequences of somatostain-28 may be present in the human gut and pancreas , it remained obscure whether or not somatostatin-28 and somatostatin-14 like immunoreactivities may be present independently in the cells since somatostatin-14 antisera have a crossreactivity to soma... | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
157,
172
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
265,
280
]
} |
relatedness among the following carrier proteins was assessed on the basis of amino acid compositions : eight acyl carrier proteins ( acp 's ) associated with fatty acid synthesis , acp 's associated with citrate lyase and citramalate lyase , a biotin carboxyl carrier protein and cytochrome 552 . | NA | {
"id": "C0007292",
"name": "carrier proteins",
"pos": [
32,
48
]
} | {
"id": "C0001369",
"name": "acyl carrier proteins",
"pos": [
110,
131
]
} |
the acceptor potency is methanol greater than ethanol greater than i-propanol greater than n-propanol greater than i-butanol greater than n-butanol . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
24,
32
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
46,
53
]
} |
the acceptor potency is methanol greater than ethanol greater than i-propanol greater than n-propanol greater than i-butanol greater than n-butanol . | NA | {
"id": "C0001977",
"name": "butanol",
"pos": [
117,
124
]
} | {
"id": "C0089147",
"name": "n-butanol",
"pos": [
138,
147
]
} |
metabolic studies revealed that estrogen inhibited androsterone , androstenedione , 5 alpha-androstane-3 alpha , 17 beta-diol , and testosterone accumulation by 80 % , dehydroepiandrosterone and 17 alpha-hydroxypregnenolone by 40 % , 17 alpha-hydroxyprogesterone by 30 % , while pregnenolone and progesterone were unchan... | NA | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
195,
223
]
} | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
279,
291
]
} |
rna synthesized in response to the hormone hybridized to both the 5 ' and 3 ' end of the gene for the precursor to ribosomal rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
0,
3
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
115,
128
]
} |
in contrast , membrane-bound adenylate cyclase seems to be linked to g/f , since it is stimulated by sodium fluoride , guanyl-5'-imidodiphosphate ( gpp ( nh ) p ) and by cholera toxin ; | NA | {
"id": "C0016327",
"name": "f",
"pos": [
71,
72
]
} | {
"id": "C0037508",
"name": "sodium",
"pos": [
101,
107
]
} |
the hormonal effect is independent of gtp concentration and is observed even in the presence of the non-hydrolysable analogue of gtp , gpp ( nh ) p . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
38,
41
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
135,
147
]
} |
in the present double-blind study the influence of keto analogs of the branched chain amino acids valine , leucine and isoleucine on plasma ammonia and encephalopathy was investigated in 12 patients with cirrhosis of the liver and surgical portal systemic shunts . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
71,
97
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
98,
104
]
} |
in the present double-blind study the influence of keto analogs of the branched chain amino acids valine , leucine and isoleucine on plasma ammonia and encephalopathy was investigated in 12 patients with cirrhosis of the liver and surgical portal systemic shunts . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
71,
97
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
122,
129
]
} |
the heidenhain pouch acid output to graded does of pentagastrin and the maximal heidenhain pouch acid and serum gastrin responses to feeding were determined in conscious cats before and after exclusion of the proximal small intestine . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
51,
63
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
112,
119
]
} |
compared with the control subjects , the content of cholesterol and apo e in the vldl was elevated in the diabetic subjects , while the area ratio of apo c-ii to apo c-iii1 was lowered . | NA | {
"id": "C0052190",
"name": "apo c-ii",
"pos": [
150,
158
]
} | {
"id": "C0003594",
"name": "apo c",
"pos": [
162,
167
]
} |
the effect of the biguanide metformin ( dimethyl-biguanide ) on insulin binding in vitro to im-9 lymphocytes and mcf-7 human breast cancer cells was studied . | NA | {
"id": "C0025598",
"name": "metformin",
"pos": [
28,
37
]
} | {
"id": "C0005382",
"name": "biguanide",
"pos": [
49,
58
]
} |
in contrast , insulin replacement ( 150 microunits . kg-1 . min-1 ) diminished lipolysis , lowered ketone production , and elevated the metabolic clearance rate of ketone bodies . | NA | {
"id": "C0022634",
"name": "ketone",
"pos": [
99,
105
]
} | {
"id": "C0022631",
"name": "ketone bodies",
"pos": [
164,
177
]
} |
a special algorithm was developed which utilizes a given blood glucose value and the glucose rate of change obtained from two to four consecutive samples as input variables . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
57,
70
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
85,
92
]
} |
a preliminary dna-binding protein analysis suggests that none of the stage-specific proteins mentioned above are dna-binding proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
84,
92
]
} | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
113,
133
]
} |
the antitumor activity of 1- ( 2-chloroethyl ) -3-isobutyl-3- ( beta-maltosyl ) -1-nitrosourea ( ta-077 ) , a novel water-soluble nitrosourea derivative , against leukemia l1210 , ehrlich carcinoma , sarcoma 180 , lewis lung carcinoma , yoshida sarcoma , rat ascites hepatomas and walker 256 carcinosarcoma was examined ... | NA | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
188,
197
]
} | {
"id": "C0243038",
"name": "lewis lung carcinoma",
"pos": [
214,
234
]
} |
in order to determine whether or not acute viral gastroenteritis predisposes to exacerbations of inflammatory bowel disease , patients with crohn 's disease and ulcerative colitis were observed longitudinally . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
97,
123
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
140,
156
]
} |
the effect of acute hyperthermia in excitatory transmitter amino acids was opposite , glutamic acid increased and aspartic acid decreased . | NA | {
"id": "C0243046",
"name": "excitatory",
"pos": [
36,
46
]
} | {
"id": "C0061472",
"name": "glutamic",
"pos": [
86,
94
]
} |
evidence is presented that streptomycin-dependent mutants of escherichia coli k-12 are incompatible with the functional activity of streptomycin-resistance genes coding for aminoglycoside adenilyl transferase . | NA | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
27,
39
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
173,
187
]
} |
the efficacy of three pilocarpine preparations in different concentrations ( pilocarpine borate 0.5 % , 1 % , 2 % ; pilocarpine hydrochloride 0.5 % , 1 % , 2 % ; pilocarpine nitrate 1 % , 2 % ) was investigated in 57 glaucomatous patients . | NA | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
22,
33
]
} | {
"id": "C0770456",
"name": "pilocarpine hydrochloride",
"pos": [
116,
141
]
} |
the efficacy of three pilocarpine preparations in different concentrations ( pilocarpine borate 0.5 % , 1 % , 2 % ; pilocarpine hydrochloride 0.5 % , 1 % , 2 % ; pilocarpine nitrate 1 % , 2 % ) was investigated in 57 glaucomatous patients . | NA | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
22,
33
]
} | {
"id": "C0351975",
"name": "pilocarpine nitrate",
"pos": [
162,
181
]
} |
the c1q subcomponent of complement ( human ) , acetylcholinesterase ( electric eel ) , and elastin ( bovine ) had no platelet aggregating activity , despite compositional homologies with collagen in terms of hydroxyproline , hydroxylysine , proline and glycine contents . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
208,
222
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
241,
248
]
} |
two complexes of lakes and canals supplying water for two electric power plants , their steam condensors and an adjoining river were investigated by means of culture methods for the presence of naegleria fowleri in poland in the period from 1974 to 1980 . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
44,
49
]
} | {
"id": "C0038225",
"name": "steam",
"pos": [
88,
93
]
} |
these strains were found in the steam condensor of the power station a and in waters polluted with warm water of this plant . | NA | {
"id": "C0038225",
"name": "steam",
"pos": [
32,
37
]
} | {
"id": "C0043047",
"name": "waters",
"pos": [
78,
84
]
} |
cefmetazole , cefamandole , and cefoperazone did not change the blood ethanol level , but these antibiotics increased the blood ach level dose-dependently . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
14,
25
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
32,
44
]
} |
these results suggested that the disulfiram-like reaction of cefmetazole , cefamandole , and cefoperazone results from an increase of the blood ach level , and the 3-substituent group in in aminocephalosporanic acid , i.e. , tz , is an important factor for the reaction . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
75,
86
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
93,
105
]
} |
the most abundantly occurring phenol compounds ( phenol , cresols , 2,4-dimethylphenol , brenzcatechine , syringol , eugenol , vanilline and guaiacol ) gave negative results when they were tested for mutagenicity at five concentrations up to 5000 micrograms/plate , with and without s-9 mix , using five strains of s. ty... | NA | {
"id": "C0031428",
"name": "phenol",
"pos": [
30,
36
]
} | {
"id": "C0010305",
"name": "cresols",
"pos": [
58,
65
]
} |
the results of the study indicated that traces of nitrosamines , usually n-nitrosodimethylamine , were present in many samples of blood , urine and gastric contents , even after an 8-hr fast . | NA | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
50,
62
]
} | {
"id": "C0012431",
"name": "nitrosodimethylamine",
"pos": [
75,
95
]
} |
the differentiation of this renal hamartoma from its most important differential diagnosis , carcinoma of the kidney , is possible only occasionally even when one includes epidemiological , clinical and angiographic findings , ct , in the other hand , provides certain pre-operative diagnosis in most cases by showing po... | NA | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
34,
43
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
334,
340
]
} |
therefore the plasma concentrations of adrenaline , noradrenaline , cortisol and some metabolic parameters ( glucose , glycerol , nefa , ketone bodies ) as well as heart rate and arterial blood pressure were measured before , during and after surgery . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
39,
49
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
52,
65
]
} |
post-infection reactions are possible not only as arthritis or septicemia but also as meningitis , conjunctivitis , carditis , pneumonia , cholecystitis , peritonitis , urinary tract infection and abortion . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
5,
14
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
169,
192
]
} |
the determination of c-peptide and proinsulin which was mainly carried out in serum or plasma essentially improved our knowledge about the function of the beta-cells in the islets of langerhans in healthy subjects and diabetic patients . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
21,
30
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
35,
45
]
} |
the paper reports on the occurrence and the course of c-peptide and proinsulin in healthy subjects and in diabetics of type i and ii . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
54,
63
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
68,
78
]
} |
strains of staphylococci sensitive and resistant to ampicillin were examined in their resistance to oxacillin , propicillin and penicillin g . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
52,
62
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
128,
140
]
} |
no crossreactions with a number of other gastrointestinal hormones such as glucagon , secretin , gip , hpp or substance p was detected . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
41,
66
]
} | {
"id": "C0036534",
"name": "secretin",
"pos": [
86,
94
]
} |
in patients with acute myelocytic leukemia ( aml , n=112 ) , acute promyelocytic leukemia ( apl , n=18 ) and acute lymphocytic leukemia ( all , n=15 ) , mean fpa levels in patients with active signs and symptoms were significantly higher ( aml : 13.5 ng/ml , apl : 20.8 ng/ml , all : 12.4 ng/ml ) than those examined dur... | NA | {
"id": "C0023487",
"name": "acute promyelocytic leukemia",
"pos": [
61,
89
]
} | {
"id": "C0023467",
"name": "aml",
"pos": [
343,
346
]
} |
in these animals , the administration of 0.5 microgram of l-thyroxine per day was associated with a marked rise in the plasma level of most amino acids , while only basic amino acid levels increased with 1.0 microgram , and levels decreased with 2.0 micrograms . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
140,
151
]
} | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
165,
181
]
} |
the parallel effects of l-leucine and bch on glutamate dehydrogenase and their vastly different abilities to act as transamination partners may account for both analogies and discrepancies in the metabolic and functional responses of the islets to these two branched-chain amino acids . | NA | {
"id": "C0023401",
"name": "leucine",
"pos": [
26,
33
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
258,
284
]
} |
half-maximal displacement was achieved by 250 ng/ml of unlabeled igf ( zurich ) , by 1.2 micrograms/ml of igf ( ulm ) , by 6.3 micrograms/ml of pro-insulin and by 17.8 micrograms/ml of insulin . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
65,
68
]
} | {
"id": "C0021666",
"name": "2",
"pos": [
87,
88
]
} |
rats produce 2 alpha-macroglobulin ( alpha m ) proteinase inhibitors , the alpha 1 m , normally found in the plasma , and the alpha 2 m , an acute phase protein . | NA | {
"id": "C0002215",
"name": "alpha-macroglobulin",
"pos": [
15,
34
]
} | {
"id": "C0001347",
"name": "acute phase protein",
"pos": [
141,
160
]
} |
in addition to other changes , the polyenoic fatty acids of the main glycerophospholipids were markedly reduced between the 3rd and 14th day of chloroquine treatment : to one half in phosphatidylcholine , to about one tenth in phosphatidylethanolamine , and to one quarter in phosphatidylinositol . | NA | {
"id": "C0162448",
"name": "glycerophospholipids",
"pos": [
69,
89
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
183,
202
]
} |
in addition to other changes , the polyenoic fatty acids of the main glycerophospholipids were markedly reduced between the 3rd and 14th day of chloroquine treatment : to one half in phosphatidylcholine , to about one tenth in phosphatidylethanolamine , and to one quarter in phosphatidylinositol . | NA | {
"id": "C0162448",
"name": "glycerophospholipids",
"pos": [
69,
89
]
} | {
"id": "C0031618",
"name": "phosphatidylethanolamine",
"pos": [
227,
251
]
} |
in addition to other changes , the polyenoic fatty acids of the main glycerophospholipids were markedly reduced between the 3rd and 14th day of chloroquine treatment : to one half in phosphatidylcholine , to about one tenth in phosphatidylethanolamine , and to one quarter in phosphatidylinositol . | NA | {
"id": "C0162448",
"name": "glycerophospholipids",
"pos": [
69,
89
]
} | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
276,
296
]
} |
the presence of these filaments combined with basal lamina suggests myoepithelial differentiation , yet it is not known whether these tumors truly originate from myoepithelium or show differentiation toward myoepithelium as a part of the neoplastic process . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
134,
140
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
238,
256
]
} |
porcine insulin effectively competed for [ 125i ] insulin binding to the cultured cells and was 30 and 90 times as potent as guinea pig insulin and porcine proinsulin in causing 50 % inhibition of [ 125i ] insulin binding ; | NA | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
0,
15
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
206,
213
]
} |
porcine insulin effectively competed for [ 125i ] insulin binding to the cultured cells and was 30 and 90 times as potent as guinea pig insulin and porcine proinsulin in causing 50 % inhibition of [ 125i ] insulin binding ; | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
8,
15
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
156,
166
]
} |
this clone , conv , which was characterized by rounded and spindle-shaped cell morphology , was not highly melanotic under the usual culture condition but had high tyrosinase ( dopa oxidase ) activity . | NA | {
"id": "C0012524",
"name": "tyrosinase",
"pos": [
164,
174
]
} | {
"id": "C0041484",
"name": "dopa oxidase",
"pos": [
177,
189
]
} |
the effect of uv irradiation on proliferation and life span of human diploid fibroblast-like cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
77,
87
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
93,
98
]
} |
the effect of low dose uv irradiation on the reinitiation of proliferative activity and on the life span of human diploid fibroblast-like cells is described . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
122,
132
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
138,
143
]
} |
the c-reactive serum protein ( crp ) is a classical acute-phase reactant of increasing diagnostical value in clinical practice . | NA | {
"id": "C0006560",
"name": "c-reactive",
"pos": [
4,
14
]
} | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
52,
72
]
} |
in the adcc assay employed , balb/c lc-containing ec at different effector/target cell ratios consistently failed to lyse bovine red blood cell ( brbc ) targets which were either trinitrophenyl ( tnp ) -modified or not modified and reacted with an appropriate antibody : a purified rabbit igg anti-brbc , or a mouse or r... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
260,
268
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
335,
344
]
} |
when target cells whose phospholipids were specifically radiolabelled at the c-2 position with [ 14c ] -arachidonic acid were treated with glt , radioactivity in the phospholipid fraction decreased . | NA | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
24,
37
]
} | {
"id": "C0771648",
"name": "phospholipid fraction",
"pos": [
166,
187
]
} |
these vesicles were also susceptible to lysis by antisera raised against placental alkaline phosphatase but were resistant to attack by antibodies raised against normal human serum and hla ( multispecific ) determinants and by a cytotoxic monoclonal antibody against human beta 2-microglobulin . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
49,
57
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
136,
146
]
} |
since the active factors could be found in the tissues other than thymocytes and non-stimulated lymphocytes , they appear to be different from thymosin , transfer factor or lymphokines derived from sensitized lymphocytes , and they were most likely not synthesized de novo . | NA | {
"id": "C0040673",
"name": "transfer factor",
"pos": [
154,
169
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
173,
184
]
} |
as measured by incorporation of extracellular radiolabeled hexoses [ 1-14c ] glucose or [ 3h ] deoxyglucose ) , the soluble chemotaxin-aggregants of granulocytes , nf-met-leu-phe , c5ades arg , bacterial filtrate , or arachidonic acid all augment transmembrane hexose uptake . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
77,
84
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
261,
267
]
} |
in addition , 10 of 11 healthy subjects not known to have had systemic h. influenzae disease also had antibodies to individual outer membrane proteins , with older children having greater amounts than did their younger siblings and with children showing a different spectrum of response than that for adults . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
158,
172
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
237,
245
]
} |
when the major surface protein ( both the 43,000- and 40,000-dalton moieties ) was electrophoretically separated from the other cell wall proteins and used to immunize a rabbit , antibodies that neutralized the infectivity of intact c. psittaci were elicited . | NA | {
"id": "C0025252",
"name": "surface protein",
"pos": [
15,
30
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
138,
146
]
} |
hsv-primed splenocytes which have been depleted of adherent cells by sequential incubation on plastic , nylon wool , and sephadex g-10 are not able to respond with a ctl response when restimulated in vitro . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
94,
101
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
104,
109
]
} |
the strong correlation of agglutination titer with mouse virulence and the expression in vivo of the antigenic determinant ( s ) reacting with wa-saa suggest that the antigen ( s ) may be associated with the pathogenicity of y. enterocolitica . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
101,
122
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
167,
174
]
} |
adrenaline , noradrenaline , glucose , glycerol and the free fatty acids ( ffa ) in the blood , as well as the heart rate and oxygen intake , were tested in six healthy male volunteers ( age : 28 +/- 6 years ) during graduated ( i ) and continuously ( ii ) increasing bicycle ergometric exercise ( upright body position ... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
13,
26
]
} |
the maximum heart rate , the vo2 max , the maximum lactate and ffa concentration show no significant difference , whereas adrenaline , noradrenaline and the glucose levels are significantly lower , and the glycerol concentration is slightly higher during the maximum test ii as compared with test i . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
122,
132
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
135,
148
]
} |
at some submaximum exercise levels , the lactate concentration and the heart rate are slightly lower , adrenaline and noradrenaline are significantly lower during test ii ; | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
103,
113
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
118,
131
]
} |
the single-stranded dna complementary to rna of the human fetal particle hybridized to dna obtained from different tissues of human adults , showing that the nucleic acids of the virus-like particles were endogenous . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
4,
23
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
87,
90
]
} |
we sought s-100 protein in sections prepared from formalin-fixed paraffin-embedded tumor and normal tissues by an immunoperoxidase technique with a rabbit anti-bovine s-100 protein antiserum as first antibody and aminoethyl carbazole as developer . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
181,
190
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
200,
208
]
} |
although the last-named drugs inhibit other arachidonate metabolic pathways too , conclusive evidence that the metabolites of the lipoxygenase pathway , and leukotrienes in particular , mediate the lai response was the fact that fpl 55712 , a competitive antagonist of srs , nullified a positive response at levels as lo... | NA | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
157,
169
]
} | {
"id": "C0038091",
"name": "a",
"pos": [
322,
323
]
} |
the calcium blocking drugs often provide an additive effect in reducing anginal episodes when combined with beta-blocking agents and sometimes provide effective relief of chronic stable angina when beta-blocking drugs are unsuccessful . | NA | {
"id": "C0002962",
"name": "anginal",
"pos": [
72,
79
]
} | {
"id": "C0340288",
"name": "chronic stable",
"pos": [
171,
185
]
} |
pulse label studies with 3h-labelled aminoacids showed that dibutyryl camp ( dbcamp ) impaired the secretion of newly synthesised protein , both total ( acid-precipitable ) and individual complement proteins ( precipitated antibody by antisera to c4 , c2 , c3 , c5 , b , p , c3b inactivator and beta 1h ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
223,
231
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
235,
243
]
} |
in the present study , their stimulating properties on rabbit peritoneal exudate cells or human peripheral blood mononuclear cells were simultaneously evaluated by testing lymphocyte activating property and pyrogenic effect of the culture supernatant . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
81,
86
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
96,
130
]
} |
at 15 min epinephrine and norepinephrine had increased 2.8- and 7-fold above the respective pre-exercise values ( p less than 0.001 ) ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
10,
21
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
26,
40
]
} |
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