text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the incidence rate of reduction limb deformities was 5.0 per 10 000 births ( 481 cases ) , of polydactyly 5.8 ( 559 ) and of syndactyly 3.1 ( 299 ) , respectively . | NA | {
"id": "C0206762",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0152427",
"name": "polydactyly",
"pos": [
94,
105
]
} |
the incidence rate of reduction limb deformities was 5.0 per 10 000 births ( 481 cases ) , of polydactyly 5.8 ( 559 ) and of syndactyly 3.1 ( 299 ) , respectively . | NA | {
"id": "C0206762",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0039075",
"name": "syndactyly",
"pos": [
125,
135
]
} |
a monoclonal antibody with a broad anti-human leucocyte specificity , designated bk 19.45 and the plant lectin concanavalin a have been labelled with the alpha-emitting cyclotron produced radiohalogen astatine-211 . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
98,
110
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
111,
125
]
} |
thus , although the total content of vitamin a in the rat fetus is low , its concentration increases more rapidly than growth during the third trimester , the liver is its preferred albeit not its sole storage site , and its fetal metabolism and excretion through the placenta to the maternal circulation are appreciable... | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
231,
241
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
246,
255
]
} |
an experiment was conducted to study the effect of dietary vitamin e ( basal alpha-tocopherol plus supplemental dl-alpha-tocopheryl acetate ) on the muscle alpha-tocopherol levels in rainbow trout . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
59,
68
]
} | {
"id": "C0994472",
"name": "alpha",
"pos": [
156,
161
]
} |
redox properties of the compounds : ascorbic acid , dehydroascorbic acid , thiols such as glutathion , cistein , british anti-lewisite ( bal ) , thiamin , riboflavin , para amino benzoic acid , biotin , 1-4 dihydronaphtoquinone and flavonoids ( flavone and derived salts , quercetin rutin , 1-epicatechin and dimer ) are... | NA | {
"id": "C0003968",
"name": "ascorbic",
"pos": [
36,
44
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
52,
72
]
} |
redox properties of the compounds : ascorbic acid , dehydroascorbic acid , thiols such as glutathion , cistein , british anti-lewisite ( bal ) , thiamin , riboflavin , para amino benzoic acid , biotin , 1-4 dihydronaphtoquinone and flavonoids ( flavone and derived salts , quercetin rutin , 1-epicatechin and dimer ) are... | NA | {
"id": "C0038734",
"name": "thiols",
"pos": [
75,
81
]
} | {
"id": "C0012383",
"name": "british",
"pos": [
113,
120
]
} |
of the several halogenated deoxyribonucleosides evaluated , iodinated deoxyuridine ( idurd ) was found to be the only viable choice as a tyd analog for pat . | NA | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
27,
47
]
} | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
70,
82
]
} |
of the several halogenated deoxyribonucleosides evaluated , iodinated deoxyuridine ( idurd ) was found to be the only viable choice as a tyd analog for pat . | NA | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
27,
47
]
} | {
"id": "C0040077",
"name": "tyd",
"pos": [
137,
140
]
} |
infectivity was quantitated in rsb-1 ( rabbit skin fibroblast ) and bhk-21 cells , and dose-response curves were found to depend on both the cell system and side effects of heat . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
51,
61
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
141,
145
]
} |
on the contrary , blue dextran interacts strongly only with human albumin , but does not bind appreciably to bovine albumin . | NA | {
"id": "C0304925",
"name": "human albumin",
"pos": [
60,
73
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
116,
123
]
} |
these results suggest that the binding sites are exposed and easily accessible in human albumin , while in bovine albumin they are sterically hindered and therefore not accessible to the bulky blue dextran . | NA | {
"id": "C0304925",
"name": "human albumin",
"pos": [
82,
95
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
114,
121
]
} |
aortic chemoreceptor activity , from single- or few-fiber afferent nerve preparations , was measured in response to dopamine and a dopaminergic blocker , haloperidol , in 18 anesthetized cats . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
116,
124
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
131,
143
]
} |
in the arctic significant daily increases over the control period of urine volume ( +86 % ) , urinary norepinephrine ( +48 % ) , epinephrine ( +84 % ) , and 17-hydroxycorticosteroids ( +34 % ) occurred in the npa group . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
102,
116
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
129,
140
]
} |
we have determined the sensitivity , linearity , and reproducibility of this system by measuring blood-to-gas phase calibration curves for the following inert gases : sulfur hexafluoride , krypton , freon 12 , enflurane , diethyl ether , and acetone . | NA | {
"id": "C0017112",
"name": "inert gases",
"pos": [
153,
164
]
} | {
"id": "C0022792",
"name": "krypton",
"pos": [
189,
196
]
} |
the proportion of unlabelled lymphocyte-like cells and granulated metrial gland precursor cells fell significantly during the period of study . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
45,
50
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
80,
95
]
} |
adrenaline- , noradrenaline- and small granule- containing cells in the adrenal gland of discoglossus pictus ( amphibia , anura ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
14,
27
]
} |
in the adrenal gland of discoglossus pictus , various types of chromaffin cells are described : noradrenaline cells , adrenaline cells and small granule-containing cells ( on the basis of electron density and shape of the granules ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
96,
109
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
118,
128
]
} |
analysis of several selection indexes combining either birth weight and yearling weight or gestation length and yearling weight indicated that continued response to selection for growth without excessive increase in birth weight is feasible . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
61,
67
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
216,
228
]
} |
the increased excretion of fecal aa following starch infusion resulted in lowered ( p less than .05 ) ad ( percentage units ) of indispensable aa , threonine ( 8.4 ) , methionine ( 6.7 ) , valine ( 6.6 ) and lysine ( 5.0 ) ; | NA | {
"id": "C0002525",
"name": "indispensable aa",
"pos": [
129,
145
]
} | {
"id": "C0040005",
"name": "threonine",
"pos": [
148,
157
]
} |
the increased excretion of fecal aa following starch infusion resulted in lowered ( p less than .05 ) ad ( percentage units ) of indispensable aa , threonine ( 8.4 ) , methionine ( 6.7 ) , valine ( 6.6 ) and lysine ( 5.0 ) ; | NA | {
"id": "C0002525",
"name": "indispensable aa",
"pos": [
129,
145
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
168,
178
]
} |
magnesium loading ( 2.4 mg/kg bw ) through continuous intrajugular infusion of mgcl2 facilitated the measurement of changes in mg clearance rate and reabsorption due to treatment . | NA | {
"id": "C0024467",
"name": "magnesium",
"pos": [
0,
9
]
} | {
"id": "C0024472",
"name": "mgcl2",
"pos": [
79,
84
]
} |
less than 100 ng nitrosamine in the total extract , or approximately 2 ng ndma or 3 ng npyr injected into the gc-ms instrument , can be confirmed by this method . | NA | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
17,
28
]
} | {
"id": "C0012431",
"name": "ndma",
"pos": [
74,
78
]
} |
the test is based on a competition between 14c-penicillin and beta-lactam antibiotics in the milk samples for sites on a microbial cell wall that specifically binds beta-lactam . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
47,
57
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
165,
176
]
} |
the test is based on a competition between 14c-penicillin and beta-lactam antibiotics in the milk samples for sites on a microbial cell wall that specifically binds beta-lactam . | NA | {
"id": "C0026458",
"name": "beta-lactam",
"pos": [
62,
73
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
165,
176
]
} |
these beta-lactamases included two types of penicillinases mediated by r plasmids and six kinds of species-specific cephalosporinases . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
6,
21
]
} | {
"id": "C0030841",
"name": "penicillinases",
"pos": [
44,
58
]
} |
these beta-lactamases included two types of penicillinases mediated by r plasmids and six kinds of species-specific cephalosporinases . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
6,
21
]
} | {
"id": "C0728805",
"name": "cephalosporinases",
"pos": [
116,
133
]
} |
short chain fatty acyl coas , such as butyryl coa , propionyl coa and acetyl coa , coa , na-palmitate , na-myristate , and palmitoyl carnitine had hardly any effect on dynein atpase . | NA | {
"id": "C0001374",
"name": "fatty acyl coas",
"pos": [
12,
27
]
} | {
"id": "C0001026",
"name": "acetyl coa",
"pos": [
70,
80
]
} |
glycyl-trna synthetase is one of two escherichia coli aminoacyl trna synthetases which has two different subunits . | NA | {
"id": "C0017983",
"name": "glycyl-trna synthetase",
"pos": [
0,
22
]
} | {
"id": "C0002529",
"name": "aminoacyl trna synthetases",
"pos": [
54,
80
]
} |
the native molecular weight of the feline enzyme was estimated to be about twice that the human isozyme by gel filtration , analytical polyacrylamide gel electrophoresis , and sucrose density-gradient centrifugation . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
42,
48
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
96,
103
]
} |
it is concluded that the majority of the rapid ca2+ efflux is mediated by partial backward reactions of the calcium pump atpase . | NA | {
"id": "C0001476",
"name": "calcium pump",
"pos": [
108,
120
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
121,
127
]
} |
measurements of polyphosphoinositides by phosphorus estimation show that , 10 s after thrombin stimulation , there is a decrease of 15-20 % of the total phosphatidylinositol 4,5-bisphosphate without any significant change in phosphatidylinositol 4-monophosphate . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
16,
37
]
} | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
225,
245
]
} |
substitution of deuterium for the alpha-hydrogen decreases the rate of reduction 1.4-fold , without any effect on the apparent kd . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
16,
25
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
40,
48
]
} |
this series of recombinant dnas was designed to study systematically the effect of neighboring dna sequences on the lac promoter . | NA | {
"id": "C0012931",
"name": "recombinant dnas",
"pos": [
15,
31
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
95,
98
]
} |
the mitochondrial proteins included 7 proteins of the inner membrane , 2 proteins of the matrix , 2 proteins of the intermembrane space , and 1 protein of the outer membrane . | NA | {
"id": "C0949610",
"name": "mitochondrial proteins",
"pos": [
4,
26
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
144,
151
]
} |
the resulting pattern of single-stranded dna fragments suggests that the nh2 termini of the core histones no longer bind strongly to the nucleosomal dna of the `` '' early '' '' mononucleosomes , and thus enhance the rate of dnase i digestion , while the presence of hmg 14 increased the solubility of these mononucleoso... | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
25,
44
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
225,
228
]
} |
there were six protein substrates uniquely affected by glucagon and one phosphoprotein uniquely stimulated by the ca2+-linked hormones . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
15,
22
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
72,
86
]
} |
thirty-eight patients who were initially treated with grafts and pulsed electromagnetic fields for ununited fractures with wide gaps , synovial pseudarthrosis , and malalignment achieved a rate of successful healing of 87 per cent . | NA | {
"id": "C0016665",
"name": "ununited fractures",
"pos": [
99,
117
]
} | {
"id": "C0033785",
"name": "pseudarthrosis",
"pos": [
144,
158
]
} |
using repeated cloning and treatment with cis-hpl ( 200 micrograms/ml ) , an analogue of a procollagen precursor inhibitory to the growth of collagen-synthesizing cells of mesenchymal origin , clonally premature epithelial cell lines were isolated from fetal sgh lungs cultured on the 15th day of gestation . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
91,
102
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
141,
149
]
} |
in immunofluorescence of keratinocyte cultures , fibronectin staining was prominent in the lining marginal cells of the expanding periphery of the epidermal cell islands but was not detected in the terminally differentiating cells in the upper layers of stratified colonies . | NA | {
"id": "C0022567",
"name": "cultures",
"pos": [
38,
46
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
225,
230
]
} |
basement membrane collagen of the 3t3 cells was found deposited as apparently unprocessed procollagen alpha 1 ( iv ) and alpha 2 ( iv ) chains . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
18,
26
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
90,
101
]
} |
the products of the in vitro assay were n-acetylglucosaminylpyrophosphoryl-lipid and n , n'-diacetylchitobiosylpyrophosphoryl-lipid for membranes from both tm-resistant and wild-type cells . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
75,
80
]
} | {
"id": "C0025249",
"name": "lipid",
"pos": [
126,
131
]
} |
fibroblasts of the estrus endometrial stroma were elongated cells with a fibrillar pattern of fibronectin on their surfaces . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
0,
11
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
60,
65
]
} |
the membrane-damaging c5b-9 ( m ) complex of complement is a cylindrically structured , amphiphilic molecule that is generated on a target membrane during complement attack . | NA | {
"id": "C0009545",
"name": "c5b-9",
"pos": [
22,
27
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
155,
165
]
} |
readdition of glucose ( 5.55 mm ) for six hours to glucose-starved cells led to a rapid decrease in hexose transport that could be blocked by cycloheximide but not actinomycin d . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
14,
21
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
100,
106
]
} |
previous studies have shown that the phorbol ester 12-o-tetradecanoylphorbol-13-acetate ( tpa ) stimulates hexose transport in undifferentiated and differentiated balb/c 3t3 cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
37,
50
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
51,
87
]
} |
to explore the relationship between energy metabolism and the limited replicative life span of cultured human fibroblasts , we studied several bioenergetic parameters in normal fibroblasts at early passage ( young cells ) and at late passage ( old cells ) and early passage cells from a subject with the hutchinson-gilfo... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
110,
121
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
274,
279
]
} |
rna polynucleotide kinase has been shown to transfer [ gamma 32p ] from atp to 5-oh termini of endogenous nuclear rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
0,
3
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
106,
117
]
} |
the cellular uptake of horseradish peroxidase and its poly ( lysine ) conjugate by cultured fibroblasts is qualitatively similar despite a 900-fold difference in rate . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
4,
12
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
92,
103
]
} |
analyses of the amount and function of rna revealed that treatment with retinoic acid leads to reductions in total rna content , in the proportion of ribosomes in polysomes , in the amount of poly ( a ) rna , and in the amount of polysome-associated mrna . | NA | {
"id": "C0887909",
"name": "function",
"pos": [
27,
35
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
251,
254
]
} |
the fused silica column gave complete resolution of all peaks ( two per hexose and one per hexitol ) arising from glucose , galactose , mannose , fructose , sorbitol , mannitol and dulcitol . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
72,
78
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
124,
133
]
} |
the fused silica column gave complete resolution of all peaks ( two per hexose and one per hexitol ) arising from glucose , galactose , mannose , fructose , sorbitol , mannitol and dulcitol . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
72,
78
]
} | {
"id": "C0024742",
"name": "mannose",
"pos": [
136,
143
]
} |
the fused silica column gave complete resolution of all peaks ( two per hexose and one per hexitol ) arising from glucose , galactose , mannose , fructose , sorbitol , mannitol and dulcitol . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
72,
78
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
146,
154
]
} |
the detection limits were 2 micrograms/ml 5-hydroxytryptophan , 1.75 micrograms/ml 5-hydroxyindolyl-3-acetic acid , 1.5 micrograms/ml tryptophan , 0.8 micrograms/ml indolyl-3-acetic acid , 0.9 micrograms/ml indolyl-3-butyric acid , 1.75 micrograms/ml serotonin , and 1.25 micrograms/ml tryptamine . | NA | {
"id": "C0000578",
"name": "hydroxytryptophan",
"pos": [
44,
61
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
134,
144
]
} |
the extraction and recovery of diazepam and its major pharmacologically active metabolites , i.e. , 3-hydroxydiazepam , desmethyldiazepam and oxazepam from blood were higher than 88 % for all compounds . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
31,
39
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
120,
137
]
} |
the simultaneous determination of azathioprine and its metabolite 6-mercaptopurine in serum by reversed-phase high-performance liquid chromatography is described . | NA | {
"id": "C0004482",
"name": "azathioprine",
"pos": [
34,
46
]
} | {
"id": "C0000618",
"name": "serum",
"pos": [
86,
91
]
} |
a small degree of cross-reactivity was detected with mumps viral antigens , both with vero cell-derived ( wild-type strain ) and egg-derived ( enders strain ) purified virus preparations and with a cell lysate antigen prepared from wild-type mumps virus-infected vero cells . | NA | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
59,
73
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
210,
217
]
} |
reactions of the viruses with rabbit antisera indicated that at least some of the virus particles were ruptured by adsorption to the polystyrene and the exposed nucleoprotein could react with antibody . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
37,
45
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
192,
200
]
} |
the results of this study are consistent with a humoral substance produced by the malignant tissue causing generalized bone resorption in addition to bone dissolution around metastases . | NA | {
"id": "C0005974",
"name": "bone resorption",
"pos": [
119,
134
]
} | {
"id": "C0221204",
"name": "bone dissolution",
"pos": [
150,
166
]
} |
insulin-like growth factors ( igfs ) in pygmies and subjects with the pygmy trait : characterization of the metabolic actions of igf i and igf ii in man . | NA | {
"id": "C0037657",
"name": "igfs",
"pos": [
30,
34
]
} | {
"id": "C0021665",
"name": "igf i",
"pos": [
139,
144
]
} |
insulin-like growth factors ( igfs ) in pygmies and subjects with the pygmy trait : characterization of the metabolic actions of igf i and igf ii in man . | NA | {
"id": "C0037657",
"name": "igfs",
"pos": [
30,
34
]
} | {
"id": "C0021666",
"name": "igf ii",
"pos": [
139,
145
]
} |
to determine whether the abnormalities in dopaminergic regulation of prl secretion in patients with prolactinomas persist after resection of the adenoma , we evaluated prl inhibitory responses to l-dopa alone and l-dopa given after pretreatment with the dopa decarboxylase inhibitor carbidopa before and after transsphen... | NA | {
"id": "C0001430",
"name": "adenoma",
"pos": [
145,
152
]
} | {
"id": "C0033375",
"name": "prolactinomas",
"pos": [
349,
362
]
} |
peripheral blood mononuclear cells obtained from patients with various skin disorders were studied by indirect immunofluorescence using the monoclonal antibodies okt3 , okt4 , and okt8 which react with human t cells ( okt3+ cells ) , helper-inducer ( okt4+ ) and suppressor-cytotoxic ( okt8+ ) t cell subsets , respectiv... | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
0,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
224,
229
]
} |
the phenotype of the cutaneous immunocompetent cells in lesions of cutaneous t cell lymphoma ( mycosis fungoides , sezary syndrome ) , lichen planus , and chronic graft-vs.-host reaction infiltrates , was examined by the use of monoclonal antibodies directed against t cell populations and langerhans cells ( okt3 , okt4... | NA | {
"id": "C0079773",
"name": "of cutaneous t",
"pos": [
64,
78
]
} | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
115,
130
]
} |
these cells respond poorly to t cell mitogens and will suppress the response of normal peripheral blood mononuclear cells to mitogens . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
87,
121
]
} |
the suggestions for technological advances in this field are : signal amplification using mixtures of monoclonal antibodies directed against different epitopes on the same antigen ( e.g . okt4a+b+d ) , triple layer amplification systems using hapten-labelled antibodies , and informative double staining methods with com... | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
102,
123
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
333,
343
]
} |
the suggestions for technological advances in this field are : signal amplification using mixtures of monoclonal antibodies directed against different epitopes on the same antigen ( e.g . okt4a+b+d ) , triple layer amplification systems using hapten-labelled antibodies , and informative double staining methods with com... | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
151,
159
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
243,
249
]
} |
using a new differentiation antigen , okt17 , which recognizes a surface antigen present on the majority of resting normal peripheral t lymphocytes but is present only on a subset of okt4+ cells after activation , evidence was obtained that two functionally mature subsets can be distinguished within the okt4+ populatio... | NA | {
"id": "C0003324",
"name": "differentiation antigen",
"pos": [
12,
35
]
} | {
"id": "C0003339",
"name": "surface antigen",
"pos": [
65,
80
]
} |
a patient is described with premature labor at 32 weeks of gestation complicated by chorioamnionitis associated with lactobacillus species , subsequent premature delivery , and possible neonatal infection . | NA | {
"id": "C0022876",
"name": "premature labor",
"pos": [
28,
43
]
} | {
"id": "C0151526",
"name": "premature",
"pos": [
152,
161
]
} |
( 10 ) presented data that suggested that human platelets contain an activated form of factor v and a factor v activator . | NA | {
"id": "C0015501",
"name": "activated",
"pos": [
69,
78
]
} | {
"id": "C0015498",
"name": "factor v",
"pos": [
102,
110
]
} |
gel chromatographic analysis showed this immunoreactivity to consist of forms corresponding to tetradecapeptide somatostatin ( s-14 ) , somatostatin-28 ( s-28 ) , and a 15,000-mol-wt molecule . | NA | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
112,
124
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
136,
151
]
} |
differential action of the bisphosphonates ( 3-amino-1-hydroxypropylidene ) -1,1-bisphosphonate ( apd ) and disodium dichloromethylidene bisphosphonate ( cl2mdp ) on rat macrophage-mediated bone resorption in vitro . | NA | {
"id": "C0012544",
"name": "bisphosphonates",
"pos": [
27,
42
]
} | {
"id": "C0012081",
"name": "cl2mdp",
"pos": [
154,
160
]
} |
this assay system permits the quantitative assessment of the action of apd and cl ( 2 ) mdp on the two major phases of bone resorption ( cell-substrate attachment and osteolysis ) under circumstances where the drugs are present continuously or , most importantly for the issues in question , after the separate pretreatm... | NA | {
"id": "C0005974",
"name": "bone resorption",
"pos": [
119,
134
]
} | {
"id": "C0221204",
"name": "osteolysis",
"pos": [
167,
177
]
} |
the number of anae-positive cells ( 1.4-3.2 % ) in reactive lymph nodes was similar to that in low-grade nhl nodes . | NA | {
"id": "C0079747",
"name": "low-grade nhl",
"pos": [
95,
108
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
105,
108
]
} |
the distribution of cholecystokinin ( cck ) -like ( cck-l ) immunoreactive cells and nerve terminals was studied in the brains from rats and guinea pigs by using antibodies to the octapeptide cholecystokinin ( cck-8 ) . | NA | {
"id": "C0008328",
"name": "cck",
"pos": [
38,
41
]
} | {
"id": "C0037167",
"name": "octapeptide cholecystokinin",
"pos": [
180,
207
]
} |
we measured the serum level and urinary excretion of clindamycin on the third day and the twenty-seventh day of therapy in thirteen patients who were applying 1 % clindamycin hydrochloride topically for acne . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
53,
64
]
} | {
"id": "C0282105",
"name": "clindamycin hydrochloride",
"pos": [
163,
188
]
} |
she delivered a 2,056-gm stillborn female fetus in the seventh month , 2 days after ultrasonography had demonstrated absence of fetal cardiac activity and other evidence of intrauterine fetal death . | NA | {
"id": "C0595939",
"name": "stillborn",
"pos": [
25,
34
]
} | {
"id": "C0015927",
"name": "intrauterine fetal death",
"pos": [
173,
197
]
} |
plasma factors ( c-reactive protein , acid alpha 1-glycoprotein , fibrinogen , fibrinopeptide a , fibrinogen-fibrin split products , factor xiii , antithrombin iii , complement factors c3 and c4 , inter-alpha-trypsin-inhibitor and alpha 2-macroglobulin ) measured during hyperdynamic septic shock were highly abnormal . | NA | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
79,
95
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
109,
115
]
} |
plasma factors ( c-reactive protein , acid alpha 1-glycoprotein , fibrinogen , fibrinopeptide a , fibrinogen-fibrin split products , factor xiii , antithrombin iii , complement factors c3 and c4 , inter-alpha-trypsin-inhibitor and alpha 2-macroglobulin ) measured during hyperdynamic septic shock were highly abnormal . | NA | {
"id": "C0163275",
"name": "fibrinogen",
"pos": [
66,
76
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
109,
115
]
} |
( 3 ) low cost of reagents due to ease of preparation -- pacia does not require purified antibodies to measure ige but only f ( ab ' ) 2 fragments of the igg fraction of the anti-ige antiserum to coat latex ; | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
89,
99
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
183,
192
]
} |
plasma catecholamines epinephrine ( e ) , norepinephrine ( ne ) , and dopamine ( da ) were measured by a radioenzymatic assay at baseline and after administration of theophylline at 1 , 2 , and 3 hr . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
22,
33
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
42,
56
]
} |
epinephrine plasma concentration was significantly greater ( p less than 0.001 ) at 3 hr compared with baseline ( 105 +/- 16 vs 56 +/- 18 pg/ml ) , while ne ( 448 +/- 52 vs 320 +/- 36 pg/ml ) did not attain significance ( p = 0.136 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
154,
156
]
} |
it was therefore apparent that immune responses of guinea pigs immunized with protein conjugates of bifunctional isocyanates were heterogeneous and involved multiple specificities for hapten , carrier protein , and new antigenic determinants . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
78,
85
]
} | {
"id": "C0007292",
"name": "carrier protein",
"pos": [
193,
208
]
} |
it was therefore apparent that immune responses of guinea pigs immunized with protein conjugates of bifunctional isocyanates were heterogeneous and involved multiple specificities for hapten , carrier protein , and new antigenic determinants . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
184,
190
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
219,
241
]
} |
antihistamines are not advised for elderly patients who have viral or bacterial infections of the nose or throat , and oral preparations containing nasal mucosal vasoconstrictors should also be avoided in managing the elderly patient who has hypertension , vascular disease , or prostatism . | NA | {
"id": "C0020538",
"name": "hypertension",
"pos": [
242,
254
]
} | {
"id": "C0042373",
"name": "vascular disease",
"pos": [
257,
273
]
} |
the development and use of dipivalyl epinephrine , an epinephrine pro-drug , represents a major advance in the pharmacological treatment of open angle glaucoma . | NA | {
"id": "C0058415",
"name": "dipivalyl epinephrine",
"pos": [
27,
48
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
54,
65
]
} |
relative to its less lipid soluble parent compound , dipivefrin has been shown in clinical trials to control intraocular pressure effectively at concentrations 10-20 times less than epinephrine with a resultant decreased incidence of ocular and systemic side effects . | NA | {
"id": "C0058415",
"name": "dipivefrin",
"pos": [
53,
63
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
182,
193
]
} |
hormone regulation of adrenaline and noradrenaline release in the inferior mesenteric ganglion of the dog . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
22,
32
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
37,
50
]
} |
the effects of hormones , hydrocortisone , cortin , prostaglandin e2 ( pge2 ) , insulin , and triiodothyronine , on the release of adrenaline ( a ) and noradrenaline ( na ) into the superfusate of the inferior mesenteric ganglion ( img ) of the dog were studied in rest and during 3 stimulations : ( 1 ) electrical stimu... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
131,
141
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
152,
165
]
} |
it is suggested that cyclic nucleotide accumulation occurs in the nerve terminals or an unknown transmitter or substance participates in the postsynaptic accumulation of the cyclic nucleotides . | NA | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
28,
38
]
} | {
"id": "C0028631",
"name": "cyclic nucleotides",
"pos": [
174,
192
]
} |
the percentage of [ 3h ] orotic acid incorporated into poly ( a ) -rna as ribosomal rna ( 38s , 18s , and 5s rnas ) or transfer rna was similar for 12- and 30-month-old rats . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
67,
70
]
} | {
"id": "C0035701",
"name": "rna",
"pos": [
128,
131
]
} |
the percentage of [ 3h ] orotic acid incorporated into poly ( a ) -rna as ribosomal rna ( 38s , 18s , and 5s rnas ) or transfer rna was similar for 12- and 30-month-old rats . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
67,
70
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
119,
131
]
} |
the association of cytochrome p-450 with the inner mitochondrial membrane , in a manner similar to that previously reported for adrenodoxin and adrenodoxin reductase ( f mitani , y ishimura , s izumi , k watanabe , acta endocrinol 90:317 , 1979 ) , establishes that the steroid monooxygenase systems exist at this site . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
19,
35
]
} | {
"id": "C0038311",
"name": "steroid monooxygenase",
"pos": [
270,
291
]
} |
human tissues obtained early postmortem were immunostained to demonstrate carbonic anhydrase ( ca ) and , in some instances , to differentiate ca i and ca ii , employing an immunoglobulin-peroxidase bridge method . | NA | {
"id": "C0007028",
"name": "carbonic anhydrase",
"pos": [
74,
92
]
} | {
"id": "C0007033",
"name": "ca i",
"pos": [
152,
156
]
} |
human tissues obtained early postmortem were immunostained to demonstrate carbonic anhydrase ( ca ) and , in some instances , to differentiate ca i and ca ii , employing an immunoglobulin-peroxidase bridge method . | NA | {
"id": "C0007028",
"name": "carbonic anhydrase",
"pos": [
74,
92
]
} | {
"id": "C0007034",
"name": "ca ii",
"pos": [
152,
157
]
} |
in fact , heavy metals with high affinity for sh groups , such as hg and cu , do prevent the silver staining reaction . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
10,
22
]
} | {
"id": "C0025424",
"name": "hg",
"pos": [
66,
68
]
} |
ouchterlony double diffusion test of the trh antisera revealed that low levels of antibodies against albumin but not immunoglobulin g or ovalbumin were also produced . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
101,
108
]
} | {
"id": "C0029923",
"name": "ovalbumin",
"pos": [
137,
146
]
} |
glycosidases ( beta-galactosidase , beta-glucosidase and beta-glucuronidase ) , in diencephalon of turtle , are observed in the myelinated fibers of tractus opticus and dorsal and ventral peduncles of lateral fore-brain bundles . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
0,
12
]
} | {
"id": "C0017776",
"name": "beta-glucuronidase",
"pos": [
57,
75
]
} |
it was found that children under five , who were scalded , were more likely to have moved than older children who had sustained a flame burn . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
18,
26
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
95,
109
]
} |
the inhibitory effect was dose-related and appeared to be specific for lps ( including naturally occurring endotoxin ) . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
71,
74
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
107,
116
]
} |
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