text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
cephalosporins developed recently such as cefotaxime , cefoperazone , ceftizoxime , latamoxef etc . show very potent antimicrobial activity against gram-negative bacilli , but their activity against s. aureus and s. epidermidis is weaker than that of cefotiam , cephalothin , cefazolin etc . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
42,
52
]
} | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
251,
259
]
} |
the therapeutic efficacy and safety of cefmetazole , a cephamycin-derived antibiotic in an injectable form were evaluated in patients with pyogenic infection in the dermatological field . | NA | {
"id": "C0007550",
"name": "cefmetazole",
"pos": [
39,
50
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
55,
65
]
} |
analysis of lipoprotein profile of plasma showed a significant increase of very low density lipoproteins ( vldl ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
12,
23
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
75,
104
]
} |
ultracentrifugation of plasma lipoproteins revealed a marked increase in chylomicron+vldl ( very low density lipoprotein ) fraction . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
30,
42
]
} | {
"id": "C0008731",
"name": "chylomicron",
"pos": [
73,
84
]
} |
ultracentrifugation of plasma lipoproteins revealed a marked increase in chylomicron+vldl ( very low density lipoprotein ) fraction . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
30,
42
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
92,
108
]
} |
paralysis was caused by gaba , avermectin bia ( av-bia ) , piperazine and alpha-adrenergic agonists such as adrenaline , noradrenaline , phenylephrine , clonidine and methoxamine , but not by beta-adrenergic agonists such as isoproterenol . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
108,
118
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
121,
134
]
} |
promotion-sensitive and promotion-resistant clonal derivatives of jb6 showed similar basal levels of collagen synthesis as well as similar degrees of tpa-dependent procollagen loss indicating that the collagen decrease may be necessary but is not sufficient to produce the promotion response . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
164,
175
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
201,
209
]
} |
lymphocyte blast transformation and granulocyte motility were studied in 20 clinically stable hemodialysis patients , 10 of whom were receiving 50 mg of zinc ( as zinc acetate ) per day and 10 of whom were not . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
153,
157
]
} | {
"id": "C0149368",
"name": "zinc acetate",
"pos": [
163,
175
]
} |
compliance with the dialysis regimen did not predict pain and the validity of the category `` '' dialysis headache '' '' was questioned . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
53,
57
]
} | {
"id": "C0018681",
"name": "headach",
"pos": [
106,
113
]
} |
choline kinase catalyzes the phosphorylation of choline to phosphorylcholine which is thus made available for phosphatidylcholine biosynthesis . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
0,
7
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
59,
76
]
} |
non-rhabdomyosarcomatous soft tissue sarcomas ( 123/238 = 51.7 % ) were synovial sarcomas ( 20 = 8.4 % ) , fibrosarcomas including spindle cell sarcoma ( 17 = 7.4 % ) , leiomyosarcomas ( 12 = 5.0 % ) , malignant tumors of the vascular system ( 11 = 4.6 % ) and neurofibrosarcomas ( 9 = 3.8 % ) . | NA | {
"id": "C0016057",
"name": "fibrosarcomas",
"pos": [
107,
120
]
} | {
"id": "C0206729",
"name": "neurofibrosarcomas",
"pos": [
261,
279
]
} |
the study showed a loss of hemodynamic reactions under mental stress in tetraplegics , namely the pressure response , the typical increase in heart rate and in plasma noradrenaline and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
167,
180
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
185,
195
]
} |
the response of plasma renin activity ( pra ) , plasma aldosterone , 18-hydroxycorticosterone ( 18-oh-b ) , 18-hydroxydeoxycorticosterone ( 18-oh-doc ) and corticosterone to furosemide were compared in 20 normal control subjects , 16 patients with normal-renin essential hypertension ( nreh ) and 12 patients with low-re... | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
69,
93
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
156,
170
]
} |
red blood cells from 10 anemic patients exhibited less glutathione and also less malondialdehyde , while gsh-peroxidase and gssg-reductase contents were higher . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
105,
108
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
124,
128
]
} |
despite the similarity of the clinical manifestations to those expected from immediate immunological hypersensitivity ( anaphylaxis ) , relatively few reactions involve antibodies . | NA | {
"id": "C0020523",
"name": "immediate",
"pos": [
77,
86
]
} | {
"id": "C0002792",
"name": "anaphylaxis",
"pos": [
120,
131
]
} |
heme was administered as hemoglobin or hemin chloride by means of an intragastric tube and also by injection into a closed duodenal loop . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
0,
4
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
39,
44
]
} |
after portocaval shunt , we observed lower plasma levels of the branched chain amino acids valine , isoleucine , leucine , and net higher levels of the aromatic tyrosine and phenylalanine and of glutamine . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
64,
90
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
100,
110
]
} |
after portocaval shunt , we observed lower plasma levels of the branched chain amino acids valine , isoleucine , leucine , and net higher levels of the aromatic tyrosine and phenylalanine and of glutamine . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
64,
90
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
113,
120
]
} |
c. absonum , when added to eubacterium sp . cultures totally prevented lithocholic acid formation when the substrate was chenodeoxycholic acid and halved deoxycholic acid formation when the substrate was cholic acid . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
121,
142
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
154,
170
]
} |
steroids were measured either directly ( testosterone and progesterone ) or after previous oxidation and thin layer chromatographic purification of the steroid extracts ( 4-androstene-3,17-dione , 5 alpha-androstane-3,17-dione , progesterone , 5 alpha-pregnane-3,20-dione ) . | NA | {
"id": "C0038317",
"name": "steroid",
"pos": [
0,
7
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
252,
260
]
} |
the dopamine agonist serotonin antagonist lisuride completely inhibited the aldosterone response to 5-methoxytryptamine ( 10 ( -8 ) mol/l ) and serotonin ( 10 ( -7 ) mol/l ) . | NA | {
"id": "C0000589",
"name": "methoxytryptamine",
"pos": [
102,
119
]
} | {
"id": "C0036751",
"name": "serotonin",
"pos": [
144,
153
]
} |
a few experiments examining lyophilization effects on steroid receptors from human breast biopsies did note some diminution of the 8s form of both er and pgr following lyophilization , although this effect was variable in extent . | NA | {
"id": "C0034840",
"name": "steroid receptors",
"pos": [
54,
71
]
} | {
"id": "C0034804",
"name": "er",
"pos": [
147,
149
]
} |
a few experiments examining lyophilization effects on steroid receptors from human breast biopsies did note some diminution of the 8s form of both er and pgr following lyophilization , although this effect was variable in extent . | NA | {
"id": "C0034840",
"name": "steroid receptors",
"pos": [
54,
71
]
} | {
"id": "C0034833",
"name": "pgr",
"pos": [
154,
157
]
} |
these findings are discussed in relation to two forms of androgen receptors that exist in a different proportion in extracts of brain and in relation to other steroid receptors . | NA | {
"id": "C0034786",
"name": "androgen receptors",
"pos": [
57,
75
]
} | {
"id": "C0034840",
"name": "steroid",
"pos": [
159,
166
]
} |
to assess the response to encainide in patients with malignant arrhythmias , we treated 22 patients with recurrent ventricular tachycardia ( vt ) or fibrillation ( vf ) refractory to an average of 5.7 drugs . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
63,
74
]
} | {
"id": "C0042510",
"name": "vf",
"pos": [
164,
166
]
} |
both drugs converted the arrhythmias at doses from 2.5 to 10 mg . kg-1 and reduced that atrial flutter rate before conversion . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
25,
36
]
} | {
"id": "C0004239",
"name": "atrial flutter",
"pos": [
88,
102
]
} |
however , women with breast cancer in their first trimester of pregnancy and in whom axillary lymph nodes are involved , should receive chemotherapy and have their pregnancy terminated . | NA | {
"id": "C0032979",
"name": "first",
"pos": [
44,
49
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
164,
173
]
} |
dna cruciform structures : implications for telomer replication in eukaryotes and instability of long palindromic dna sequences in prokaryotes . | NA | {
"id": "C1258072",
"name": "dna cruciform",
"pos": [
0,
13
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
114,
117
]
} |
mnu and mms react with dna without being first metabolized and show a higher uds in lower concentration than dmn which is metabolized enzymatically prior to the reaction . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
23,
26
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
163,
164
]
} |
it is therefore postulated that defective repair of 0 ( 6 ) -methylguanine could be one of the factors determining the susceptibility of autoimmune diseases in genetically predisposed individuals . | NA | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
119,
133
]
} | {
"id": "C0314657",
"name": "genetically",
"pos": [
160,
171
]
} |
this observation has led to the hypothesis that overactivity of dopaminergic pathways is the cause of the psychotic symptoms , but a seeming anomaly is that the turnover of dopamine is not increased in schizophrenia . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
64,
76
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
173,
181
]
} |
chronic intrathecal infusion of dadl for 5 days caused a shift of dose response curves of both dadl and morphine sulfate injected intrathecally to the right indicating that tolerance and cross tolerance to morphine had developed after long term intrathecal infusion of dadl . | NA | {
"id": "C0066814",
"name": "morphine",
"pos": [
104,
112
]
} | {
"id": "C0026549",
"name": "morphine",
"pos": [
206,
214
]
} |
tissue copper levels of brindled ( mobr ) mice and normal litter-mates after single and repeated dosing with cucl2 and/or d-penicillamine are examined , together with a study of the cytosol distribution of copper after cucl2 treatment . | NA | {
"id": "C0009968",
"name": "copper",
"pos": [
7,
13
]
} | {
"id": "C0056593",
"name": "cucl2",
"pos": [
219,
224
]
} |
specific binding and pharmacological interactions of apamin , the neurotoxin from bee venom , with guinea pig colon . | NA | {
"id": "C0003521",
"name": "apamin",
"pos": [
53,
59
]
} | {
"id": "C0004920",
"name": "bee venom",
"pos": [
82,
91
]
} |
this paper describes the interaction of apamin , the bee venom neurotoxin , with its receptor in the guinea pig colon . | NA | {
"id": "C0003521",
"name": "apamin",
"pos": [
40,
46
]
} | {
"id": "C0004920",
"name": "bee venom",
"pos": [
53,
62
]
} |
neurotensin ( nt ) , a neuropeptide found both centrally and peripherally , stimulated release of histamine from rat peritoneal mast cells in a dose-dependent manner . | NA | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
0,
11
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
23,
35
]
} |
all the halogenated biphenyls increased microsomal benzo [ a ] pyrene hydroxylase ( or aryl hydrocarbon hydroxylase , ahh ) , ethoxyresorufin ( er ) o-deethylase and dimethylaminoantipyrine ( dmap ) n-demethylase . | NA | {
"id": "C0005080",
"name": "benzo [ a ] pyrene hydroxylase",
"pos": [
51,
81
]
} | {
"id": "C0003927",
"name": "aryl hydrocarbon",
"pos": [
87,
103
]
} |
all the halogenated biphenyls increased microsomal benzo [ a ] pyrene hydroxylase ( or aryl hydrocarbon hydroxylase , ahh ) , ethoxyresorufin ( er ) o-deethylase and dimethylaminoantipyrine ( dmap ) n-demethylase . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon",
"pos": [
87,
103
]
} | {
"id": "C0059735",
"name": "ethoxyresorufin",
"pos": [
126,
141
]
} |
chronotropic responses to sympathomimetic amines of isolated atrial preparations from toads ( bufo marinus ) were mediated by beta-adrenoceptors since isoprenaline was more potent than adrenaline and noradrenaline , and propranolol was a potent antagonist ( pa2 , adrenaline as agonist = 9.33 ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
200,
213
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
264,
274
]
} |
there was no evidence that the response was mediated by both beta 1- and beta 2-adrenoceptors since schild plots for ici 118,551 using three agonists of differing selectivity ( adrenaline , rimiterol and noradrenaline ) were superimposed . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
177,
187
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
204,
217
]
} |
in the plasma of 4 subjects homozygous for deficiency of lecithin : cholesterol acyltransferase , the level of many apolipoproteins ( apo a-i , apo a-ii , apo b , apo d ) was greatly relative to normal , while that of apo e is increased 5-fold . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
116,
131
]
} | {
"id": "C0003593",
"name": "apo b",
"pos": [
155,
160
]
} |
in the plasma of 4 subjects homozygous for deficiency of lecithin : cholesterol acyltransferase , the level of many apolipoproteins ( apo a-i , apo a-ii , apo b , apo d ) was greatly relative to normal , while that of apo e is increased 5-fold . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
116,
131
]
} | {
"id": "C0052193",
"name": "apo d",
"pos": [
163,
168
]
} |
in the plasma of 4 subjects homozygous for deficiency of lecithin : cholesterol acyltransferase , the level of many apolipoproteins ( apo a-i , apo a-ii , apo b , apo d ) was greatly relative to normal , while that of apo e is increased 5-fold . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
116,
131
]
} | {
"id": "C0003595",
"name": "apo e",
"pos": [
218,
223
]
} |
when fibroblasts were incubated with fibrinogen-free unfractionated lcat-deficient plasma , there was no spontaneous net transport of sterol either into or from the cells , indicating that efflux and influx rates were in balance . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
5,
16
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
165,
170
]
} |
no sex related differences in body weight , body fat mass , sum of skinfold thickness or fat cell weight were found throughout the study . | NA | {
"id": "C0005911",
"name": "differences",
"pos": [
15,
26
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
98,
104
]
} |
based upon these observations , we suggest that fructose feeding produces hypertriglyceridemia by directly stimulating hepatic vldl-tg secretion , as well as by producing insulin resistance and hyperinsulinemia , and that it is the combined effect of these two separate actions which accounts for the magnitude of fructo... | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
171,
189
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
194,
210
]
} |
to investigate the interaction of subunits a and b of dna gyrase during dna supercoiling , a cour mutant of escherichia coli was obtained and the effect of nalidixic acid on the supercoiling of dna by wild-type and mutant enzymes was assayed . | NA | {
"id": "C0919262",
"name": "b",
"pos": [
36,
37
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
194,
197
]
} |
separation of pbm into purified t cells , b cells and macrophages showed that cell-cell cooperation of t cells with b cells or macrophages is necessary for the observed synergistic effect of bu-wsa with con a . | NA | {
"id": "C1321301",
"name": "pbm",
"pos": [
14,
17
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
118,
122
]
} |
in vitro activity of cefotaxime , ceftizoxime , cefmenoxime , and latamoxef in comparison with other beta-lactam antibiotics against recent clinical isolates of haemophilus influenzae and haemophilus parainfluenzae . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
21,
31
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
34,
45
]
} |
in vitro activity of cefotaxime , ceftizoxime , cefmenoxime , and latamoxef in comparison with other beta-lactam antibiotics against recent clinical isolates of haemophilus influenzae and haemophilus parainfluenzae . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
21,
31
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
48,
59
]
} |
an improvement of liver diseases could be reached as follows : lupoid hepatitis 84 % , chronic aggressive hepatitis with strong activity 78 % , chronic aggressive hepatitis with low activity 53 % , chronic persisting hepatitis 34 % , mixed form of chronic aggressive hepatitis and primary biliary cirrhosis 34 % , hbsag-... | NA | {
"id": "C0023895",
"name": "of liver diseases",
"pos": [
15,
32
]
} | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
467,
476
]
} |
an improvement of liver diseases could be reached as follows : lupoid hepatitis 84 % , chronic aggressive hepatitis with strong activity 78 % , chronic aggressive hepatitis with low activity 53 % , chronic persisting hepatitis 34 % , mixed form of chronic aggressive hepatitis and primary biliary cirrhosis 34 % , hbsag-... | NA | {
"id": "C0023895",
"name": "of liver diseases",
"pos": [
15,
32
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
363,
372
]
} |
an improvement of liver diseases could be reached as follows : lupoid hepatitis 84 % , chronic aggressive hepatitis with strong activity 78 % , chronic aggressive hepatitis with low activity 53 % , chronic persisting hepatitis 34 % , mixed form of chronic aggressive hepatitis and primary biliary cirrhosis 34 % , hbsag-... | NA | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
70,
79
]
} | {
"id": "C0019189",
"name": "chronic",
"pos": [
448,
455
]
} |
the effects of agonists on 32p labeling of phosphatidylinositol , in order of potency , were epinephrine greater than or equal to norepinephrine greater than phenylephrine much greater than normetanephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
130,
144
]
} |
the effects of agonists on 32p labeling of phosphatidylinositol , in order of potency , were epinephrine greater than or equal to norepinephrine greater than phenylephrine much greater than normetanephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
130,
144
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
190,
205
]
} |
therefore , although hamster hepatic coasac-dependent sulfamethazine n-acetyltransferase may be associated with n-arylhydroxamic acid n , o-acyltransferase , the coasac-dependent p-aminobenzoic acid n-acetyltransferase appears to be a different enzyme . | NA | {
"id": "C0001390",
"name": "acyltransferase",
"pos": [
140,
155
]
} | {
"id": "C0001068",
"name": "acetyltransferase",
"pos": [
201,
218
]
} |
the use of n-arylhydroxamic acids as suicide substrates is a promising technique for probing the mechanism of n-arylhydroxamic acid n , o-acyltransferase-mediated reactions , for exploring the relationships between n-arylhydroxamic acid n , o-acyltransferase and coasac-dependent n-acetyltransferases , and for selective... | NA | {
"id": "C0001390",
"name": "acyltransferase",
"pos": [
138,
153
]
} | {
"id": "C0001068",
"name": "acetyltransferases",
"pos": [
383,
401
]
} |
nucleotide levels and incorporation of 5-fluorouracil and uracil into dna of cells treated with 5-fluorodeoxyuridine . | NA | {
"id": "C0016360",
"name": "fluorouracil",
"pos": [
41,
53
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
58,
64
]
} |
exposure of bovine caudate homogenates to 53 degrees rapidly ( less than 4 min ) abolishes subsequent specific binding of the agonist ligand [ 3h ] dopamine to d-3 sites but not that of the butyrophenone dopaminergic antagonist [ 3h ] spiroperidol to d-2 sites in bovine caudate membranes . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
148,
156
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
204,
216
]
} |
exposure of bovine caudate homogenates to 53 degrees rapidly ( less than 4 min ) abolishes subsequent specific binding of the agonist ligand [ 3h ] dopamine to d-3 sites but not that of the butyrophenone dopaminergic antagonist [ 3h ] spiroperidol to d-2 sites in bovine caudate membranes . | NA | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
190,
203
]
} | {
"id": "C0037956",
"name": "spiroperidol",
"pos": [
235,
247
]
} |
in addition , heat treatment and maximal guanine nucleotide addition ( 300 microm gtp ) cause identical decreases in the affinities of agonists in the displacement of [ 3h ] spiroperidol , and similar increases in pseudo-hill coefficient of these displacements . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
41,
59
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
82,
85
]
} |
this activation of phosphodiesterase by calmodulin was completely inhibited by two opioid peptides , beta-endorphin and dynorphin , at concentrations that had no appreciable effect on the basal phosphodiesterase activity . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
83,
98
]
} | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
120,
129
]
} |
inhibition of erythroid differentiation appears to require the incorporation of thymidine analogs into dna , and thus only 5-ethyl-2'-deoxyuridine and 5-bromo-2'-deoxyuridine were effective in inhibiting dimethyl sulfoxide-induced differentiation . | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
134,
146
]
} | {
"id": "C0006233",
"name": "5-bromo-2",
"pos": [
151,
160
]
} |
small nuclear rnp isolated from human cells under the same conditions as used for drosophila and selected by the anti-u1 rnp-specific antibody contains eight proteins , two of which are similar in molecular weight to the two drosophila u1 rnp proteins . | NA | {
"id": "C0142661",
"name": "small nuclear rnp",
"pos": [
0,
17
]
} | {
"id": "C0035544",
"name": "rnp",
"pos": [
239,
242
]
} |
a recombinant library of human dna sequences was screened with a segment of simian virus 40 ( sv40 ) dna that spans the viral origin of replication . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
101,
104
]
} |
a half-life of 2 min was found for the permease mrna in labeling kinetics experiments . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
2,
11
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
65,
73
]
} |
genetically homozygous line 413 dystrophic chickens were given twice-daily intraperitoneal injections of solutions containing branched-chain amino acids ( bcca-leucine , valine , isoleucine ) either alone or in combination ; | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
126,
152
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
182,
189
]
} |
genetically homozygous line 413 dystrophic chickens were given twice-daily intraperitoneal injections of solutions containing branched-chain amino acids ( bcca-leucine , valine , isoleucine ) either alone or in combination ; | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
126,
152
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
170,
176
]
} |
genetically homozygous line 413 dystrophic chickens were given twice-daily intraperitoneal injections of solutions containing branched-chain amino acids ( bcca-leucine , valine , isoleucine ) either alone or in combination ; | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
126,
152
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
179,
189
]
} |
in an effort to decrease deaths from gram-negative bacteremia and endotoxin shock , we treated bacteremic patients with human antiserum to endotoxin ( lipopolysaccharide ) core . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
66,
75
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
151,
169
]
} |
intraarterial injection of alpha-latrotoxin ( alpha ltx ) , the major toxin of the black widow spider ( latrodectus mactans tredecimguttatus ) venom , into carotid catheterized rats , induced prompt and marked rises in plasma adrenaline and noradrenaline concentrations , indicating that the toxin stimulates catecholami... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
226,
236
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
241,
254
]
} |
pretreatment with the ganglionic blocker chlorisondamine greatly reduced the plasma adrenaline response to alpha ltx but had almost no effect on the noradrenaline response , indicating that alpha ltx-stimulation of sympathetic nerve terminals is direct , whereas catecholamine release from the adrenal medulla is probabl... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
84,
94
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
149,
162
]
} |
the spontaneous release of norepinephrine , epinephrine and dopamine of tracheal incubates was increased at days 1 and 4 following vaccination . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
27,
41
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
44,
55
]
} |
adrenaline and noradrenaline produced both constriction and dilatation of the toad renal vasculature : constrictor effects were mediated by alpha-adrenoceptors ; | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
} |
there was a marked seasonal variation in the constrictor responses to adrenaline , but not to noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
70,
80
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
94,
107
]
} |
the response to adrenaline in summer was also significantly greater than the responses to noradrenaline in both summer and winter . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
16,
26
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
90,
103
]
} |
determination of dissociation constants for phentolamine indicated that adrenaline and noradrenaline acted on the same population of alpha-adrenoceptors in both summer and winter . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
72,
82
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
87,
100
]
} |
a 70k and a 120k radioiodinated proteins were immunoprecipitated from all transformed cells and , to a markedly lesser extent from untransformed fibroblasts by the immune serum against rat type-c endogenous virus . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
86,
91
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
145,
156
]
} |
in some cases where dyskinesias are associated with sensory deafferentation , but not with chronic pain or hyperpathia , the same positive effect of thalamic stimulation on the control of abnormal movements is achieved while in other cases of tremor or dyskinesias without sensory deafferentation such as parkinsonism , ... | NA | {
"id": "C0040822",
"name": "tremor",
"pos": [
243,
249
]
} | {
"id": "C0013384",
"name": "dyskinesias",
"pos": [
253,
264
]
} |
hence , discriminative sensory deaffrentation is the common link between the cases of tremor or dyskinesias that use to respond to i.t.s . which is up to now the only therapy of proven efficacy in such conditions . | NA | {
"id": "C0040822",
"name": "tremor",
"pos": [
86,
92
]
} | {
"id": "C0013384",
"name": "dyskinesias",
"pos": [
96,
107
]
} |
the results indicate that morphine and the enkephalins evoke hypothalamo-pituitary-adrenocortical activity by stimulating specific receptors in the hypothalamus and raise the possibility that opioid peptides and their receptors are physiologically important in the control of the secretion of crf . | NA | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
43,
54
]
} | {
"id": "C0205753",
"name": "opioid",
"pos": [
192,
198
]
} |
the amino acids glycine and glutamine serve as substrates for the synthesis of purines in man . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
4,
15
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
16,
23
]
} |
abnormal anterior pituitary responsiveness to acute administration of thyrotropin-releasing hormone was investigated in 8 patients , 6 women and 2 men , with primary affective disorders in a depressive phase and in 2 women with schizoaffective disorders . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
9,
27
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
70,
81
]
} |
adrenoleukodystrophy -- its diverse ct appearances and an evolutive or phenotypic variant : the leukodystrophy without adrenal insufficiency . | NA | {
"id": "C0162309",
"name": "adrenoleukodystrophy",
"pos": [
0,
20
]
} | {
"id": "C0001623",
"name": "adrenal insufficiency",
"pos": [
119,
140
]
} |
in three cases , neurological signs , ct scans , and conjunctival and skin biopsies were highly suggestive of adrenoleukodystrophy , but there was no adrenal insufficiency . | NA | {
"id": "C0162309",
"name": "adrenoleukodystrophy",
"pos": [
110,
130
]
} | {
"id": "C0001623",
"name": "adrenal insufficiency",
"pos": [
150,
171
]
} |
even if we also excluded all headache , all trauma , all alcoholism , and all vertebrogenic pain states , 3.6 % of the general population at any one time should be under neurologic care . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
29,
37
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
92,
96
]
} |
the activities and isozyme patterns of seven enzymes involved in glycolysis , the malate-aspartate shuttle and the pentose phosphate pathway have been examined in five transplantable murine hepatomas , adult liver and fetal liver . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
19,
26
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
45,
52
]
} |
the developmental expression of the activity and isozyme pattern of these enzymes have been determined . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
49,
56
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
74,
81
]
} |
cells with protoplasmic pigment granules on the surface of intraocular lens implants can be divided by their basic nature into histiocytes , epitheloid cells , giant cells , small fibroblast-like cells , iris melanocytes , pigment epithelium , and probably corneal endothelium . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
0,
5
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
180,
190
]
} |
because of the consistent association of chronic smoking with the development of cancers of the head and neck , the effects of smoking and age on levels of acute phase proteins ( alpha 1-antitrypsin , haptoglobin , alpha 1-acid glycoprotein ) and other immune reactive proteins ( alpha 2hs-glycoprotein , prealbumin ) we... | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
156,
176
]
} | {
"id": "C0002191",
"name": "alpha 1-antitrypsin",
"pos": [
179,
198
]
} |
because of the consistent association of chronic smoking with the development of cancers of the head and neck , the effects of smoking and age on levels of acute phase proteins ( alpha 1-antitrypsin , haptoglobin , alpha 1-acid glycoprotein ) and other immune reactive proteins ( alpha 2hs-glycoprotein , prealbumin ) we... | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
156,
176
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
201,
212
]
} |
because of the consistent association of chronic smoking with the development of cancers of the head and neck , the effects of smoking and age on levels of acute phase proteins ( alpha 1-antitrypsin , haptoglobin , alpha 1-acid glycoprotein ) and other immune reactive proteins ( alpha 2hs-glycoprotein , prealbumin ) we... | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
156,
176
]
} | {
"id": "C0029297",
"name": "alpha 1-acid",
"pos": [
215,
227
]
} |
the hemolytic-uremic syndrome is a distinct entity of variable severity and unknown etiology characterized by hemolytic anemia , renal failure , and thrombocytopenia . | NA | {
"id": "C0019061",
"name": "hemolytic-uremic syndrome",
"pos": [
4,
29
]
} | {
"id": "C0002878",
"name": "hemolytic anemia",
"pos": [
110,
126
]
} |
the putrescine/spermidine ratio increased in the lv and decreased in the rv immediately after birth up to day 7 . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
4,
14
]
} | {
"id": "C0037871",
"name": "ratio",
"pos": [
26,
31
]
} |
a supplement of the branched chain amino acids , valine , isoleucine , and leucine ( vil ) was administered orally to patients with phenylketonuria , either together with unrestricted diet of natural protein or with a low phenylalanine diet . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
20,
46
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
49,
55
]
} |
a supplement of the branched chain amino acids , valine , isoleucine , and leucine ( vil ) was administered orally to patients with phenylketonuria , either together with unrestricted diet of natural protein or with a low phenylalanine diet . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
20,
46
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
58,
68
]
} |
a supplement of the branched chain amino acids , valine , isoleucine , and leucine ( vil ) was administered orally to patients with phenylketonuria , either together with unrestricted diet of natural protein or with a low phenylalanine diet . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
20,
46
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
75,
82
]
} |
[ clinical importance of the comprehensive study of transamidinase , lactate and malate dehydrogenases and isoenzymes of the redox enzymes in glomerulonephritis and pyelonephritis in children ] . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
107,
117
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
131,
138
]
} |
hedamycin forms a stable complex with dna and introduces alkali labile linkages in the dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
3,
4
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
87,
90
]
} |
extracts obtained from cells infected with the geminivirus tomato golden mosaic ( tgmv ) are shown to contain , in addition to viral single-stranded dna , several novel species of virus-specific single- and double- stranded dna ( ss and ds dna ) . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
133,
152
]
} | {
"id": "C0012854",
"name": "double",
"pos": [
207,
213
]
} |
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