text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the microcirculatory effects were pronounced in response to epinephrine , but blood-borne and nerve-released norepinephrine also evoked marked effects . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
60,
71
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
109,
123
]
} |
to test this hypothesis , homozygous brattleboro strain rats were given arginine vasopressin ( avp ) or 1-desamino-8-d-arginine vasopressin ( ddavp ) in the drinking water in concentrations of 10-10,000 micrograms/l ( avp ) and 5-10,000 micrograms/l ( ddavp ) . | NA | {
"id": "C0011701",
"name": "drinking water",
"pos": [
157,
171
]
} | {
"id": "C0003779",
"name": "avp",
"pos": [
254,
257
]
} |
epinephrine and norepinephrine concentrations were measured by radioenzymatic assay in plasma obtained simultaneously from the distal aorta and inferior vena cava in 15 chronically catheterized fetuses with the mother breathing 20 , 10 , or 8 % oxygen mixtures . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} |
their products have been tested in radioimmunoassays using 125i-labeled hcg , luteinizing hormone ( lh ) , follicle-stimulating hormone ( fsh ) , thyroid-stimulating hormone ( tsh ) , the alpha ( alpha ) and beta ( beta ) subunits of hcg and lh , and the c-terminal peptide 109-145 ( ctp ) of cg . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
72,
75
]
} | {
"id": "C0106132",
"name": "beta",
"pos": [
215,
219
]
} |
the extent of complement-mediated sperm immobilization varied with immunoglobulin class and with the location of antibody bound to the sperm surface . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
67,
87
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
113,
121
]
} |
the pathologic conditions that were encountered were hypercortisolism ( 74 patients ) , hyperaldosteronism ( 46 patients ) , adrenocortical carcinoma ( 35 patients ) , pheochromocytoma ( 77 patients ) , and nonfunctioning adenoma ( 47 patients ) . | NA | {
"id": "C0001622",
"name": "hypercortisolism",
"pos": [
53,
69
]
} | {
"id": "C0020428",
"name": "hyperaldosteronism",
"pos": [
88,
106
]
} |
mortality was significantly high in cases with the following clinical features : ( 1 ) epilepsy with onset before the first birthday ( mortality being 25.5 % ) , ( 2 ) symptomatic epilepsy in etiology ( 17.2 % ) , ( 3 ) infantile spasms ( 40.7 % ) , tonic epilepsy ( 33.3 % ) or myoclonic epilepsy ( 33.3 % ) as compared... | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
87,
95
]
} | {
"id": "C0014550",
"name": "myoclonic",
"pos": [
279,
288
]
} |
mortality was significantly high in cases with the following clinical features : ( 1 ) epilepsy with onset before the first birthday ( mortality being 25.5 % ) , ( 2 ) symptomatic epilepsy in etiology ( 17.2 % ) , ( 3 ) infantile spasms ( 40.7 % ) , tonic epilepsy ( 33.3 % ) or myoclonic epilepsy ( 33.3 % ) as compared... | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
87,
95
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
349,
356
]
} |
after 120 min , when steady-state bronchodilation was achieved , five terbutaline inhalations ( 1.25 mg terbutaline sulphate ) were added to both treatment regimens . | NA | {
"id": "C0039542",
"name": "terbutaline",
"pos": [
70,
81
]
} | {
"id": "C0039543",
"name": "terbutaline sulphate",
"pos": [
104,
124
]
} |
thus , the allergenicity of the complex mixture of antigens in a timothy extract is similarly expressed in animals immunized parenterally with alum as in patients sensitized by inhalation . | NA | {
"id": "C0002092",
"name": "allergenicity",
"pos": [
11,
24
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
51,
59
]
} |
anti-igg antibodies ( anti-igg ) of the ige class were studied in sera from patients with juvenile rheumatoid arthritis ( jra ) , rheumatoid arthritis ( ra ) and patients with felty 's syndrome ( fs ) by use of an indirect immunofluorescence technique . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
99,
119
]
} | {
"id": "C0015773",
"name": "felty 's syndrome",
"pos": [
176,
193
]
} |
sixty-three per cent of 30 patients with ra and 80 % of 20 patients with fs had ige anti-igg , the titers found in fs patients being significantly higher . | NA | {
"id": "C0003873",
"name": "ra",
"pos": [
41,
43
]
} | {
"id": "C0015773",
"name": "fs",
"pos": [
115,
117
]
} |
differences obtained in the levels of apo a-i in hdl2 and in hdl3 by immunoprecipitation show that the more lipoproteins are lipid rich the less their apo a-i are reached by antibodies . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
108,
120
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
125,
130
]
} |
serum angiotensin conversion enzyme ( serum ace ) is a dipeptidylcarboxypeptidase which activates angiotensin i to angiotensin ii and inactivates bradykinine . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
6,
17
]
} | {
"id": "C0003006",
"name": "angiotensin i",
"pos": [
115,
128
]
} |
serum angiotensin conversion enzyme ( serum ace ) is a dipeptidylcarboxypeptidase which activates angiotensin i to angiotensin ii and inactivates bradykinine . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
6,
17
]
} | {
"id": "C0003009",
"name": "angiotensin",
"pos": [
115,
126
]
} |
in addition , the considerable surface area represented by the endothelium of the pulmonary circulation is a site of synthesis and elimination , the implications of which are increasingly important in the area of the metabolism of endogenous substances : prostaglandins , vasomotor substances and the bioconversion of dr... | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
131,
142
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
217,
227
]
} |
pulmonary mycoses are represented above all by candidiosis , aspergillosis and rarely cryptococcosis which also commonly occur in the presence of an impaired underlying state . | NA | {
"id": "C0024116",
"name": "pulmonary",
"pos": [
0,
9
]
} | {
"id": "C0004030",
"name": "aspergillosis",
"pos": [
61,
74
]
} |
in our experience , kenalog injection into a hypertrophic burn scar always has resulted in improvement of the condition although it is usually necessary to give multiple injections into the hypertrophic burn scar at eight week intervals . | NA | {
"id": "C2004491",
"name": "scar",
"pos": [
63,
67
]
} | {
"id": "C0162810",
"name": "hypertrophic",
"pos": [
190,
202
]
} |
piperacillin and mezlocillin demonstrate significant activity against the enterobacteriaceae , including many strains of klebsiella pneumoniae against which the older penicillins carbenicillin , ticarcillin , and ampicillin are ineffective . | NA | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
0,
12
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
213,
223
]
} |
piperacillin and mezlocillin demonstrate significant activity against the enterobacteriaceae , including many strains of klebsiella pneumoniae against which the older penicillins carbenicillin , ticarcillin , and ampicillin are ineffective . | NA | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
17,
28
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
213,
223
]
} |
it is pointed out that , before c-peptide determination on serum from insulin-treated diabetic subjects , a peg precipitation , to remove antibody-bound proinsulin , should be done . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
32,
41
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
153,
163
]
} |
it is pointed out that , before c-peptide determination on serum from insulin-treated diabetic subjects , a peg precipitation , to remove antibody-bound proinsulin , should be done . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
70,
77
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
153,
163
]
} |
finally , it is necessary for the investigator to be thoroughly familiar with the enzyme and its isozymes and the clinical heterogeneity of the disease . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
82,
88
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
97,
105
]
} |
immunoreactive insulin ( iri ) and its three constituents as determined by gel filtration : high molecular weight substances with insulin immunoreactivity ( hwiri ) , proinsulin ( pi ) and insulin ( i ) , were measured hourly during 28 hours in the portal , hepatic and peripheral venous systems of a patient operated fo... | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
167,
177
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
189,
196
]
} |
the clinical findings in the patient included intrauterine growth retardation , microcephaly , truncus arteriosus type 1 , respiratory distress and craniofacial dysmorphism . | NA | {
"id": "C0025958",
"name": "microcephaly",
"pos": [
80,
92
]
} | {
"id": "C0376634",
"name": "craniofacial dysmorphism",
"pos": [
148,
172
]
} |
the single-cell proteins may contain trehalose , the absorption of which by the human intestine necessitates prior hydrolysis by trehalase , a specific brush-border disaccharidase . | NA | {
"id": "C0040814",
"name": "trehalase",
"pos": [
129,
138
]
} | {
"id": "C0012610",
"name": "disaccharidase",
"pos": [
165,
179
]
} |
the membranolytic c5b-9 complement membrane attach complex ( mac ) is assembled after activation of either the classic or the alternative complement pathway . | NA | {
"id": "C0009545",
"name": "c5b-9",
"pos": [
18,
23
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
138,
148
]
} |
in 66 biopsy specimens containing necrotic muscle fibers ( duchenne dystrophy , 13 ; other dystrophies , 15 ; inflammatory myopathies , 31 ; miscellaneous myopathies , 7 ) all of the necrotic fibers reacted for mac neoantigen ( s ) . | NA | {
"id": "C0027121",
"name": "inflammatory myopathies",
"pos": [
110,
133
]
} | {
"id": "C0026848",
"name": "myopathies",
"pos": [
155,
165
]
} |
n-monoethyl derivatives of carminomycin , rubomycin , 13-dihydrocarminomycin and 13-dihydrorubomycin were synthesized by condensation of their amino groups with acetic aldehyde in the presence of sodium boron hydride . | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
27,
39
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
91,
100
]
} |
antibacterial activity of n-ethyl- and n , n-diethyl derivatives of carminomycin and rubomycin determined with the use of bac . mycoides as the test microbe was 40-50 per cent and that of n-ethyl- and n , n-diethyl-13-dihydro-derivatives was 15-30 per cent of the activity of the respective antibiotics , carminomycin an... | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
68,
80
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
322,
331
]
} |
they were resistant to nalidixic acid , clindamycin and lincomycin and sensitive to novobiocin and vancomycin . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
40,
51
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
56,
66
]
} |
the ability of clavulanic acid to protect amoxicillin in vivo was confirmed by the efficacy of amoxicillin-clavulanic acid formulations in the treatment of the infections studied , most of which were refractory to therapy with amoxicillin . | NA | {
"id": "C0054066",
"name": "amoxicillin-clavulanic acid",
"pos": [
95,
122
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
227,
238
]
} |
with the 10 american leishmania isolates tested , several purines reversed the inhibitory effects of allopurinol , but only adenine countered the inhibitory effects of app . | NA | {
"id": "C0034140",
"name": "purines",
"pos": [
58,
65
]
} | {
"id": "C0002144",
"name": "allopurinol",
"pos": [
101,
112
]
} |
with the 10 american leishmania isolates tested , several purines reversed the inhibitory effects of allopurinol , but only adenine countered the inhibitory effects of app . | NA | {
"id": "C0034140",
"name": "purines",
"pos": [
58,
65
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
124,
131
]
} |
finally , and contrary to previous claims , the reversal by purines of the allopurinol-induced growth inhibition was not a leishmania species-specific effect . | NA | {
"id": "C0034140",
"name": "purines",
"pos": [
60,
67
]
} | {
"id": "C0002144",
"name": "allopurinol",
"pos": [
75,
86
]
} |
in staphylococcus aureus , using the imidazoles miconazole and ketoconazole , detailed studies of minimal inhibitory concentrations , kinetics of growth , viability , and release of intracellular k+ confirm that the two imidazoles work differently in this bacterium . | NA | {
"id": "C0025942",
"name": "miconazole",
"pos": [
48,
58
]
} | {
"id": "C0020924",
"name": "imidazoles",
"pos": [
220,
230
]
} |
of the new beta-lactam antibiotics tested , azthreonam and moxalactam were the most active , followed by cefoperazone , cefotaxime , and ceftizoxime . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
120,
130
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
137,
148
]
} |
cloning the gentamicin resistance gene from a pseudomonas aeruginosa plasmid in escherichia coli enhances detection of aminoglycoside modification . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
12,
22
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
119,
133
]
} |
exposure to ambient levels of ozone ( 0.5 ppm ) was shown to alter the pathogenesis of respiratory infection after aerosol infection of mice with influenza a virus . | NA | {
"id": "C0035243",
"name": "respiratory infection",
"pos": [
87,
108
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
123,
132
]
} |
adrenocorticotropin-dependent particulate guanylate cyclase in rat adrenal and adrenocortical carcinoma : comparison of its properties with soluble guanylate cyclase and its relationship with acth-induced steroidogenesis . | NA | {
"id": "C0018358",
"name": "guanylate cyclase",
"pos": [
42,
59
]
} | {
"id": "C1097411",
"name": "soluble guanylate",
"pos": [
140,
157
]
} |
forty-eight ( 70 % ) children presented with gastrointestinal symptoms ( vomiting , diarrhoea , colic , abdominal pain , failure to thrive ) , 16 ( 24 % ) children with skin manifestations ( eczema , urticaria , angioneurotic oedema , other rashes ) , and 4 ( 6 % ) children with wheeze . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
200,
209
]
} | {
"id": "C0002994",
"name": "angioneurotic oedema",
"pos": [
212,
232
]
} |
the bowel obstruction caused by the intussusception was evident within 8 days of major laparotomy in 8 children and within 39 days in the other two . | NA | {
"id": "C0021843",
"name": "bowel obstruction",
"pos": [
4,
21
]
} | {
"id": "C0021933",
"name": "intussusception",
"pos": [
36,
51
]
} |
the overall incidence of symptomatic postoperative arrhythmias was 31 % in the control group : 6 patients ( 19 % ) had atrial fibrillation or flutter and 4 patients ( 12 % ) , ventricular arrhythmias . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
51,
62
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
119,
138
]
} |
a total of 40 patients with drug-refractory , life-threatening cardiac rhythm disturbances -- ventricular tachycardia in 23 patients and ventricular fibrillation in 17 patients -- underwent extended endocardial resection ( eer ) of scar tissue . | NA | {
"id": "C0003811",
"name": "cardiac rhythm",
"pos": [
63,
77
]
} | {
"id": "C0042510",
"name": "ventricular",
"pos": [
137,
148
]
} |
at the oral doses of racemic fenfluramine tested the ration of the auc for d-norfenfluramine to d-fenfluramine was 4.4 , 2.0 , 0.8 , 0.3 , and the dog , rat man and mouse respectively . | NA | {
"id": "C0028362",
"name": "norfenfluramine",
"pos": [
77,
92
]
} | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
98,
110
]
} |
na stores in heart sympathetic nerves were depleted , but the drug had no effect on the adrenaline content of adrenal glands . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
0,
2
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
88,
98
]
} |
on the contrary , agonist ( clonidine , guanfacine , alpha-methyl-noradrenaline , noradrenaline and adrenaline ) displacement curves were shallow with hill-coefficients of approximately 0.7 . | NA | {
"id": "C0025805",
"name": "alpha-methyl-noradrenaline",
"pos": [
53,
79
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
82,
95
]
} |
on the contrary , agonist ( clonidine , guanfacine , alpha-methyl-noradrenaline , noradrenaline and adrenaline ) displacement curves were shallow with hill-coefficients of approximately 0.7 . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
66,
79
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
100,
110
]
} |
pv , ivc and pa obtained from shr were less extensible , developed more tension , exhibited an enhanced sensitivity to serotonin and a thromboxane-like prostanoid , accumulated more of the protein precursors 2-14c-leucine , 2-14c-glucosamine , 7-3h-fucose , exhibited a normal rate of uptake of 2-14c-thymidine , and inc... | NA | {
"id": "C0033665",
"name": "protein precursors",
"pos": [
189,
207
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
327,
334
]
} |
seizure activity in animals given enprofylline and theophylline , two xanthines with partly different mechanisms of action . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
51,
63
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
70,
79
]
} |
the pheochromocytomas secreted epinephrine as well as norepinephrine and resided in or next to the adrenal gland . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
31,
42
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
54,
68
]
} |
in a case of death from burning , the examination of the corpse ( 80 year old female pensioner , walking disability , almost blind , heavy smoker ) resulted in a number of remarkable findings : epidural burn hematoma , retraction and rupture of the dura mater , cauliflower-like swelling of the brain in the frontal area... | NA | {
"id": "C0011065",
"name": "death",
"pos": [
13,
18
]
} | {
"id": "C0006629",
"name": "corpse",
"pos": [
57,
63
]
} |
the underlying malformations were : certain forms of fallot 's tetralogy ( 16 cases ) , transposition of the great arteries with ventricular septal defect and pulmonary stenosis ( 8 cases ) , truncus arteriosus ( 9 cases ) , double outlet right ventricle ( 6 cases ) , other malformations ( 4 cases ) . | NA | {
"id": "C0040761",
"name": "transposition of the great arteries",
"pos": [
88,
123
]
} | {
"id": "C0013069",
"name": "double outlet right ventricle",
"pos": [
225,
254
]
} |
a breast lump in a 46-year-old woman proved on histologic examination to be an adenoma of the `` '' mixed '' '' salivary type ( pleomorphic adenoma ) . | NA | {
"id": "C0001430",
"name": "adenoma",
"pos": [
79,
86
]
} | {
"id": "C0026277",
"name": "( pleomorphic adeno",
"pos": [
126,
145
]
} |
the patient is a young man with paraplegia whose hospitalization was prolonged due to isolated right long thoracic nerve palsy . | NA | {
"id": "C0030486",
"name": "paraplegia",
"pos": [
32,
42
]
} | {
"id": "C0522224",
"name": "palsy",
"pos": [
121,
126
]
} |
c-hdl/tc ratio was calculated and ldl-cholesterol value ( c-ldl ) according to the friedwald-fredrickson 's formula was obtained . | NA | {
"id": "C0008377",
"name": "c-hdl",
"pos": [
0,
5
]
} | {
"id": "C0023824",
"name": "ldl-cholesterol",
"pos": [
34,
49
]
} |
of the total neutral lipids , 77.3 per cent were represented by free fatty acids , 14.7 per cent by cholesterol , 4.1 per cent by triglycerides and 3.2 per cent by cholesterol esters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
100,
111
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
164,
182
]
} |
the glycolipid fraction was comprised of simple glycosphingolipids ( 11.3 per cent ) , mainly lactosyl- and glucosylceramides , and of neutral and sulphated glyceroglucolipids ( 88.7 per cent ) . | NA | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
4,
14
]
} | {
"id": "C0017978",
"name": "glycosphingolipids",
"pos": [
48,
66
]
} |
the neurohypophysial hormones vasopressin ( the antidiuretic hormone ) and oxytocin have been quantified in xerophilic and mesophilic rodents under normal and dehydrated conditions in order to study the relative contribution of these hormones to survival under drought conditions . | NA | {
"id": "C0032017",
"name": "neurohypophysial hormones",
"pos": [
4,
29
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
75,
83
]
} |
the neurohypophysial hormones vasopressin ( the antidiuretic hormone ) and oxytocin have been quantified in xerophilic and mesophilic rodents under normal and dehydrated conditions in order to study the relative contribution of these hormones to survival under drought conditions . | NA | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
30,
41
]
} | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
48,
68
]
} |
the putative central catecholamine neurotransmitters , adrenaline , noradrenaline and dopamine , have been quantified by enzyme radiochemical methods in the hypothalamo-neurohypophysial system ( hns ) of the xeric rodents , notomys alexis and pseudomys australis , using the laboratory rat for comparison . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
55,
65
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
68,
81
]
} |
all three catecholamines were found ( noradrenaline greater than dopamine greater than adrenaline ) in the hypothalami of the three species . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
87,
97
]
} |
these findings , which were comparable with those induced by partial hepatectomy , indicate the existence in dmna-treated cells of a chromatin dna relaxation similar to the g0-g1 transition previously described for human diploid fibroblasts stimulated to proliferate . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
229,
240
]
} |
the influence of different fixatives ( 4 % formaldehyde , methanol-acetic acid , methanol-formalin-acetic acid ) and hydrolysis kinetics ( performed at 23 degrees c and 60 degrees c ) on the chromatin availability to the feulgen reaction of cerebellar purkinje neurons has been examined . | NA | {
"id": "C0016564",
"name": "formaldehyde",
"pos": [
43,
55
]
} | {
"id": "C0949307",
"name": "formalin",
"pos": [
90,
98
]
} |
( 3 ) the levels of activity of total esterases , carboxylesterases , mixed-function oxidases , epoxide hydrase , and glutathione transferase in the parent strains and their hybrids were measured quantitatively . | NA | {
"id": "C0014894",
"name": "esterases",
"pos": [
38,
47
]
} | {
"id": "C0007067",
"name": "carboxylesterases",
"pos": [
50,
67
]
} |
the three esterases were designated carboxylesterases based on their responses to the two esterase inhibitors , eserine and paraoxon ( diethyl-p-nitrophenyl phosphate ) . | NA | {
"id": "C0014894",
"name": "esterases",
"pos": [
10,
19
]
} | {
"id": "C0007067",
"name": "carboxylesterases",
"pos": [
36,
53
]
} |
the beta-adrenergic catecholamine receptor , reflected by isoproterenol 's effect on activation by pretreatment with p [ nh ] ppg , increased the concentration of catalytic subunits in the c* state but had an insignificant ( p > 0.05 ) effect on the k ( m ) at every temperature . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
20,
33
]
} | {
"id": "C0022245",
"name": "isoproterenol 's",
"pos": [
58,
74
]
} |
the amino acid composition of highly-purified pig intestinal peroxidase showed a relative abundance of basic amino acids ( lysine and arginine ) and was similar to that of lactoperoxidase , but not that of myeloperoxidase . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0301714",
"name": "basic",
"pos": [
103,
108
]
} |
the amino acid composition of highly-purified pig intestinal peroxidase showed a relative abundance of basic amino acids ( lysine and arginine ) and was similar to that of lactoperoxidase , but not that of myeloperoxidase . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
103,
108
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
123,
129
]
} |
the amino acid composition of highly-purified pig intestinal peroxidase showed a relative abundance of basic amino acids ( lysine and arginine ) and was similar to that of lactoperoxidase , but not that of myeloperoxidase . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
103,
108
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
134,
142
]
} |
treatment of human immunoglobulin g , albumin and fibronectin with water-soluble carbodi-imide at ph4.75 in the presence of glycine ethyl ester resulted in an avid binding of ( 125 ) i-labelled native fibrinectin to the modified proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
38,
45
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
229,
237
]
} |
the binding of radiolabelled fibronectin to the carbodi-imide-treated proteins was inhibited by unlabelled fibronectin in relatively low concentrations , but also by albumin in higher concentrations . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
70,
78
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
166,
173
]
} |
the results were interpreted as showing that : ( 1 ) fibronectin is capable of binding to itself , to immunoglobulin g and to albumin after a reduction of the negative surface charge of these proteins , and may have a general ability to bind such modified proteins ; | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
126,
133
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
256,
264
]
} |
incubation of iron with isolated rat liver nuclei stimulated fragmentation of single-stranded dna , incorporation of [ 3h ] thymidine into dna and the binding of 59fe to dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
78,
97
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
170,
173
]
} |
a distance plot obtained using the blocked nucleotide concept , which regards the repeating nucleotide moieties to be made up of two blocks of nearly equal magnitude , has permitted us to visualize the polynucleotide backbone folding in yeast trnaphe . | NA | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
43,
53
]
} | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
202,
216
]
} |
diethyldithiocarbamate ( dtc ) and carbon disulfide ( cs2 ) , at nearly equimolar oral dose levels , protected mice against liver damage induced by carbon tetrachloride , chloroform , bromotrichloromethane , thioacetamide , bromobenzene , furosemide , acetaminophen , dimethylnitrosamine and trichloroethylene , as evide... | NA | {
"id": "C0008238",
"name": "chloroform",
"pos": [
171,
181
]
} | {
"id": "C0006241",
"name": "bromotrichloromethane",
"pos": [
184,
205
]
} |
cytidine , deoxycytidine , adenosine and deoxyadenosine seem to inhibit thymidine degradation by reducing the intracellular transport of thymidine . | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
0,
8
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
11,
24
]
} |
turkey erythrocyte membranes , whose adenylate cyclase enzyme is usually poorly responsive to the direct actions of gtp or its analogue , gpp ( nh ) p , became markedly responsive after previous exposure to isoproterenol in a sucrose-containing buffer . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
116,
119
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
138,
150
]
} |
the repressive effect of sp was dependent on its proteolytic activity and was far stronger than those of other proteases tested . | NA | {
"id": "C0030946",
"name": "sp",
"pos": [
25,
27
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
111,
120
]
} |
other classes of anticonvulsants failed to antagonise pentobarbital activation , suggesting that these interactions may occur at a specific barbiturate site in the membrane . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
54,
67
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
140,
151
]
} |
there is some similarity in patterns of isotype distribution of anti-f ( ab ' ) 2 antibodies and rheumatoid factors . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
40,
47
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
82,
92
]
} |
the combination of this sterilization procedure with an adsorption and elution procedure leads to coagulation factor concentrates such as fibrinogen , factor viii and factor ix concentrate and a stabilized serum preparation for intravenous use . | NA | {
"id": "C0005789",
"name": "coagulation factor",
"pos": [
98,
116
]
} | {
"id": "C0015506",
"name": "factor viii",
"pos": [
151,
162
]
} |
it was shown that the biological activity of the immunoglobulins , transport proteins and inhibitor proteins was not affected by the manufacturing process . | NA | {
"id": "C0007292",
"name": "transport proteins",
"pos": [
67,
85
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
100,
108
]
} |
the cholesterol-benzarone diet causes a body weight reduction of 10 % , a relative increase of serum hdl and a corresponding decrease of serum ldl and vldl , as compared with the effects of the cholesterol diet . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
4,
15
]
} | {
"id": "C0008395",
"name": "cholesterol diet",
"pos": [
194,
210
]
} |
the duration of the hypotensive effect was 2-3 h shorter with lofexidine than with clonidine . | NA | {
"id": "C0065152",
"name": "shorter",
"pos": [
49,
56
]
} | {
"id": "C0009014",
"name": "clonidine",
"pos": [
83,
92
]
} |
to determine the nature of lipid and apoprotein exchange between human high density lipoproteins ( hdl ) and intralipid particles of sf greater than 400 ( ilip ) we have studied their in vitro interaction during incubation in aqueous buffer and in lipoprotein-deficient serum ( lpds ) . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
27,
32
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
248,
259
]
} |
in the presence of lpds the exchange of nonpolar lipids occurred between the two particles : in the case of hdl , cholesteryl ester content decreased , accompanied by an increase in triglyceride , causing a decrease in the hydrated density of the lipoprotein and an increase in its molecular weight ; | NA | {
"id": "C0023820",
"name": "lpds",
"pos": [
19,
23
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
49,
55
]
} |
effects of fibrin and fibrinogen-degradation products on the growth of rabbit aortic smooth muscle cells in culture . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
11,
17
]
} | {
"id": "C0163275",
"name": "fibrinogen-degradation products",
"pos": [
22,
53
]
} |
effects of fibrin and fibrinogen degradation products ( fdp ) on the growth of smooth muscle cells ( smc ) of rabbit aortas in culture were investigated , in relation to atherogenesis . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
11,
17
]
} | {
"id": "C0163275",
"name": "fibrinogen degradation",
"pos": [
22,
44
]
} |
the reduction in absolute amounts of apo c-ii was also reflected in a reduction of the ratio apo c-ii/apo c-iii in very low density lipoproteins ( vldl ) and in a reduction in the ability of the sera to activate skim milk lipoprotein lipase . | NA | {
"id": "C0052190",
"name": "apo c-ii",
"pos": [
37,
45
]
} | {
"id": "C0003594",
"name": "apo c-ii/apo c-iii",
"pos": [
93,
111
]
} |
the paper deals with a comparative analysis of the results of using 2 methods of investigation ( daily holter 's monitoring of ecg and bicycle ergometry in patients with paroxysmal heart rhythm disturbances ( group 1 ) and in those with extrasystole ( group 2 ) . | NA | {
"id": "C0003811",
"name": "heart rhythm disturbances",
"pos": [
181,
206
]
} | {
"id": "C0340464",
"name": "extrasystole",
"pos": [
237,
249
]
} |
in 40.9 % of patients with paroxysmal rhythm disturbances and 64.7 % of those with extrasystole , arrhythmias were provoked by trials with a dosed physical exercise . | NA | {
"id": "C0340464",
"name": "extrasystole",
"pos": [
83,
95
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
98,
109
]
} |
the concentrations of heavy metals hg , pb and cd found in zooplankton samples collected in two stations off cesenatico ( northern adriatic sea ) from march 1978 to january 1979 , have been reported . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
22,
34
]
} | {
"id": "C0025424",
"name": "hg",
"pos": [
35,
37
]
} |
for decades , neurooncologists have argued for the use of primary , autochthonous tumors rather than transplanted tumors such as c 6 glioma cells and 9 l gliosarcoma cells . | NA | {
"id": "C0017638",
"name": "glioma",
"pos": [
133,
139
]
} | {
"id": "C0206726",
"name": "cells",
"pos": [
166,
171
]
} |
in order to study the effects of antipsychotics on kindling process and the epileptic events , pharmacological action of antipsychotics on kindling process and the kindled convulsions , and changes in ( 3h ) -spiperon binding following kindling were studied in this study . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
76,
85
]
} | {
"id": "C0036572",
"name": "convulsions",
"pos": [
172,
183
]
} |
active drug or placebo was continued for 7 days or until ( a ) detection of `` '' warning arrhythmias ' requiring i.v . lignocaine intervention ( greater than 5 for 7 days or until ( a ) detection of `` '' warning arrhythmias ' requiring i.v . lignocaine intervention ( greater than 5 premature ventricular contractions ... | NA | {
"id": "C0003811",
"name": "g arrhythmi",
"pos": [
88,
99
]
} | {
"id": "C0042510",
"name": "r ventricul",
"pos": [
410,
421
]
} |
the 6 nitroimidazole compounds in order of increasing effectiveness as potentiators of melphalan activity were : metro , ro 05-9963 , miso , rsu 1047 , ro 03-8800 and ro 03-8799 . | NA | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
6,
20
]
} | {
"id": "C0025872",
"name": "metro",
"pos": [
113,
118
]
} |
125i-propylthiouracil is also accumulated in melanotic melanoma cells in vivo and in vitro , but at a lower level than in 125i-tu and 14c-tu . | NA | {
"id": "C0033511",
"name": "propylthiouracil",
"pos": [
5,
21
]
} | {
"id": "C0039957",
"name": "14c-tu",
"pos": [
134,
140
]
} |
lectins are proteins which have the ability to interact specifically with carbohydrate residues of glycoproteins and other glycoconjugates . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
0,
7
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
104,
112
]
} |
lectins are proteins which have the ability to interact specifically with carbohydrate residues of glycoproteins and other glycoconjugates . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
74,
86
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
123,
138
]
} |
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