text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
lectins are proteins which have the ability to interact specifically with carbohydrate residues of glycoproteins and other glycoconjugates . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
99,
112
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
123,
138
]
} |
the optically detected magnetic resonance ( odmr ) spectra of the covalent dna adduct of 9,10-epoxy-9,10,11,12-tetrahydrobenzo [ e ] pyrene ( bepe ) reveal that the excited triplet state chromophore is perturbed by the nucleic acid and that this perturbation is diminished successively by denaturation and enzymatic hydr... | NA | {
"id": "C0242958",
"name": "dna",
"pos": [
75,
78
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
343,
346
]
} |
the optically detected magnetic resonance ( odmr ) spectra of the covalent dna adduct of 9,10-epoxy-9,10,11,12-tetrahydrobenzo [ e ] pyrene ( bepe ) reveal that the excited triplet state chromophore is perturbed by the nucleic acid and that this perturbation is diminished successively by denaturation and enzymatic hydr... | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
219,
231
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
343,
346
]
} |
other properties of phfi are a pi of 8.3 , 29 amino acid residues , amino-terminal arginine , carboxyl-terminal glycine , 3 cystine residues , undetectable sulfhydryl groups and carbohydrate , and arginine at the reactive site . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
46,
56
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
112,
119
]
} |
these observations , and those previously reported for activation of spin-labeled pig pepsinogen , are incorporated into a model of pepsinogen activation . | NA | {
"id": "C0030913",
"name": "pepsinogen",
"pos": [
86,
96
]
} | {
"id": "C0077923",
"name": "a",
"pos": [
148,
149
]
} |
in the presence of cytochrome c , edc promotes formation of amide cross-links between lysine amino groups on cytochrome c and their complementary carboxyl groups on cytochrome c oxidase . | NA | {
"id": "C0010749",
"name": "cytochrome c",
"pos": [
19,
31
]
} | {
"id": "C1256752",
"name": "groups",
"pos": [
155,
161
]
} |
for the study of the protein -- protein and protein -- nucleic acid interactions in the assembly of virus particles , laser raman spectra have been obtained in h2o and d2o solutions and as a function of temperature for the following salmonella phage p22 components : mature phage particles , isolated mature phage dna , ... | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
55,
67
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
351,
354
]
} |
for the study of the protein -- protein and protein -- nucleic acid interactions in the assembly of virus particles , laser raman spectra have been obtained in h2o and d2o solutions and as a function of temperature for the following salmonella phage p22 components : mature phage particles , isolated mature phage dna , ... | NA | {
"id": "C0033665",
"name": "precursor protein",
"pos": [
357,
374
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
446,
454
]
} |
cleavage of alpha 2m by four serine proteases ( plasmin , thrombin , trypsin , and elastase ) as determined by sodium dodecyl sulfate gel electrophoretic analyses and the binding of plasmin and thrombin as measured by macromolecular inhibitor assays corresponded to the increase in fluorescence intensity . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
29,
45
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
69,
76
]
} |
cleavage of alpha 2m by four serine proteases ( plasmin , thrombin , trypsin , and elastase ) as determined by sodium dodecyl sulfate gel electrophoretic analyses and the binding of plasmin and thrombin as measured by macromolecular inhibitor assays corresponded to the increase in fluorescence intensity . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
29,
45
]
} | {
"id": "C0030306",
"name": "elastase",
"pos": [
83,
91
]
} |
cleavage of alpha 2m by four serine proteases ( plasmin , thrombin , trypsin , and elastase ) as determined by sodium dodecyl sulfate gel electrophoretic analyses and the binding of plasmin and thrombin as measured by macromolecular inhibitor assays corresponded to the increase in fluorescence intensity . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
29,
45
]
} | {
"id": "C0016016",
"name": "plasmin",
"pos": [
182,
189
]
} |
the interaction of monovalent cations with activated bovine plasma protein c ( apc ) has been examined by kinetic methods , with h-d-phenylalanylpipecolylarginine-p-nitroanilide ( s-2238 ) being employed as the substrate . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
19,
37
]
} | {
"id": "C0033727",
"name": "h",
"pos": [
208,
209
]
} |
these data indicate that an active participation of the cation in the amidolytic activity of apc exists , which is correlated with the ionic radius of the cation . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
135,
140
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
155,
161
]
} |
the various metal hybrid enzymes do not differ appreciably in their abilities to incorporate noncomplementary nucleotide or deoxyribonucleotide into rna product . | NA | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
110,
120
]
} | {
"id": "C0011529",
"name": "deoxyribonucleotide",
"pos": [
124,
143
]
} |
the lifetime for opening of individual base pairs in a dna ( dca5g + dct5g ) , and rna ( rca5g + rcu5g ) , and a hybrid dna-rna ( rca5g + dct5g ) helix have been measured by proton nuclear magnetic resonance . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
53,
58
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
120,
123
]
} |
the ca2+-atpase ( atp phosphohydrolase , ec 3.6.1.3 ) in human erythrocyte membranes , which is part of the ca2+ pump , can be activated by binding of calmodulin . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
4,
7
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
18,
38
]
} |
determination of the transfer kinetics shows ( 1 ) that pancreatic microsomal phosphatidylinositol is partitioned approximately equally between a non-exchangeable and a single exchangeable pool and ( 2 ) that cholinergic stimulation does not significantly change the relative sizes of the two pools nor the exchange half... | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
30,
38
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
316,
325
]
} |
differences of fatty acid composition of phospholipids and unsaturated percentage of fatty acids were observed between these two vesicles . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
15,
25
]
} | {
"id": "C0015690",
"name": "unsaturated",
"pos": [
59,
70
]
} |
in diamide-treated g6pd-deficient red cells ( and in glucose deprived normal cells ) , glutathione ( gsh ) is oxidized to glutathione disulfide ( gssg ) . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
101,
104
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
146,
150
]
} |
two nadph-linked aldehyde reductases ( alcohol : nadp+ oxidoreductase , ec 1.1.1.2 ) , referred to here as aldehyde reductases i and ii , have been purified to homogeneity from human liver by using ammonium sulfate precipitation , ion-exchange chromatography , affinity chromatography and gel filtration . | NA | {
"id": "C0027298",
"name": "nadph",
"pos": [
4,
9
]
} | {
"id": "C0027312",
"name": "nadp",
"pos": [
49,
53
]
} |
substrate specificity studies show that neither aldehyde reductase i nor ii uses glucose as substrate but that both are capable of reducing various other aldehydes such as pyridine 3-aldehyde , butyraldehyde and dl-glyceraldehyde . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
154,
163
]
} | {
"id": "C0017854",
"name": "glyceraldehyde",
"pos": [
215,
229
]
} |
this phenomeon ( deinhibition ) was caused by monovalent anions , cl- , br- , i- and scn- . f- and clo4- showed partial deinhibition . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
57,
63
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
129,
130
]
} |
this phenomeon ( deinhibition ) was caused by monovalent anions , cl- , br- , i- and scn- . f- and clo4- showed partial deinhibition . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
57,
63
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
92,
93
]
} |
elution peaks from ion-exchange chromatography of the hemoglobins termed hba1a , hba1b , hba1c and hba studied by isoelectric focusing revealed that : hba1a formed two bands and hba1b one band far toward the anode ; | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
54,
65
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
178,
181
]
} |
the activator was inhibited by benzamidine , leupeptin , soybean trypsin inhibitor and diisopropyl fluorophosphate , suggesting that the activator is a trypsin-type serine protease . | NA | {
"id": "C0041236",
"name": "trypsin",
"pos": [
65,
72
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
165,
180
]
} |
among proteins that could be identified , dopamine beta-hydroxylase was at a low level in the microsomes , while the granule membrane protein cytochrome b-561 appeared to be in both fractions . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
6,
14
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
125,
141
]
} |
at the same time , there occurred a significant accumulation of radioactivity in either cholinephosphate or diacylglycerol molecule from [ 14c ] choline or [ 3h ] glycerol , respectively , suggesting that 3-methylcholanthrene could cause an inhibitory effect on hepatic phosphatidylcholine synthesis at the cholinephosph... | NA | {
"id": "C0031716",
"name": "cholinephosphate",
"pos": [
88,
104
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
340,
347
]
} |
in vitro incubations of human or pig plasma containing a tracer amount of [ 3h ] cholesterol have been performed to determine which lipoprotein fractions are the immediate recipients of the esterified cholesterol formed in the reaction catalysed by lecithin : cholesterol acyltransferase . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
81,
92
]
} | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
190,
212
]
} |
these results show that the supplementation of a glyceryl ether to l-m fibroblast growth media selectively inhibits the utilization of choline for choline glycerophospholipid biosynthesis and causes a reduction in cell growth rate when cells are continually passaged in the presence of the glyceryl ether . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
71,
81
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
236,
241
]
} |
the synthesis and maintenance of membrane lipids ( phospholipids and free sterols ) and their coupling in cellular metabolism are discussed in light of these results . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
33,
48
]
} | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
51,
64
]
} |
under such conditions , tsh did not stimulate the adenylate cyclase activity unless exogenous gtp or gpp [ nh ] p was added . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
94,
97
]
} | {
"id": "C0018366",
"name": "gpp [ nh ] p",
"pos": [
101,
113
]
} |
our finding that ceramide is accumulated in the lysosomal fraction of farber 's fibroblasts and that these cells also show membranous inclusions strongly suggests that the accumulation of ceramide is directly involved in the formation of lysosomal inclusions . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
80,
91
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
107,
112
]
} |
incubation of platelets with prostaglandin e1 and isobutylmethylxanthine inhibited thrombin-stimulated secretion and the phosphorylation of the 38 and 20 kda protein and increased the phosphorylation of the 67 and 27 kda phosphoproteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
158,
165
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
221,
236
]
} |
replicative dna synthesis in normal human fibroblasts was inhibited by 50 % when they were x-irradiated ( 8 gy ) and made permeable 30 min later , whereas only a slight inhibition ( 20 % ) was observed in similarly treated ataxia-telangiectasia cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
42,
53
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
245,
250
]
} |
two iminoxyl radicals mainly localized in a lipid bilayer and in the membrane lipid layers adjacent to protein were applied . | NA | {
"id": "C0023768",
"name": "lipid bilayer",
"pos": [
44,
57
]
} | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
69,
83
]
} |
156 globulin reacts 4.6-fold more efficiently with denatured reca protein , and it reacts partially with the native tif-1 , lexb30 , reca44 , and reca629 proteins , as well as with peptide fragments which are not common to all four proteins . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
4,
12
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
232,
240
]
} |
the only common properties shared by these four enzymes are : an activity twice as high on single stranded dna than on double stranded dna and no requirement for divalent cation for maximal activity . | NA | {
"id": "C0012935",
"name": "single stranded dna",
"pos": [
91,
110
]
} | {
"id": "C0012854",
"name": "double stranded dna",
"pos": [
119,
138
]
} |
stationary cultures of human fibroblasts were exposed to various doses of carcinogens ( uv-light at 254 nm , n-acetoxy-acetyl-aminofluorene , ethyl-methane sulfonate , n-methylnitro-nitrosoguanidine , mitomycin c and 4-nitroquinoline-n-oxide ) at different time-intervals before preparing crude cellular extracts and ass... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
29,
40
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
295,
303
]
} |
b. the carcinogen treatment of either repair-proficient human fibroblasts or repair-deficient xeroderma pigmentosum cells ( complementation group a ) seems to induce a specific increase of the 4s-form of dna ligase . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
62,
73
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
116,
121
]
} |
in these analogs the amino acid statin essential for the inhibitory action was substituted for the residues of natural amino acids serine , threonine and glycine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
119,
130
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
154,
161
]
} |
the role of estradiol-17 beta ( e2 ) in migration of the porcine embryo was examined ( experiment 1 ) by observing the distribution of silastic ( polydimethyl siloxane , medical adhesive silicone type a , dow corning ) beads impregnated with cholesterol or e2 ( n=5 gilts per treatment ) after 5 days in utero ( day 12 o... | NA | {
"id": "C0012436",
"name": "polydimethyl",
"pos": [
146,
158
]
} | {
"id": "C0037114",
"name": "silicone",
"pos": [
187,
195
]
} |
on day 6 of gestation the tip of each uterine horn was exposed and the subserosa of each of 5 gilts was injected with either vehicle , 8 mg of cromolyn sodium ( an inhibitor of histamine release ) or 8 mg of cromolyn sodium plus 1 mg of histamine . | NA | {
"id": "C0012694",
"name": "cromolyn sodium",
"pos": [
143,
158
]
} | {
"id": "C0086073",
"name": "cromolyn",
"pos": [
208,
216
]
} |
ion-solvent interactions play a very important role in the studies of stoichiometry , structure , and stability of complexes of cations with natural and synthetic ionophores . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
0,
3
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
128,
135
]
} |
the implications of these findings for fundamental studies on subunit proteins and protein assemblies and for conventional applications of ultracentrifugation are discussed . | NA | {
"id": "C0599220",
"name": "subunit proteins",
"pos": [
62,
78
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
83,
90
]
} |
brown-adipose-tissue mass , protein content , and mitochondrial protein were all decreased in the food-deprived rats , and specific and total depot mitochondrial gdp-binding capacity were 29 and 53 % lower than controls . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
28,
35
]
} | {
"id": "C0949610",
"name": "mitochondrial protein",
"pos": [
50,
71
]
} |
a condensation of pyroglutamic acid , alanine and another amino acid component xxx ( xxx = gly , val , leu or gly-tyr ) preferentially yielded the dipeptide pyroglu-ala , but the formation of the tripeptide pyroglu-ala-ala became strongly reduced because of competing reactions . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
38,
45
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
58,
68
]
} |
a condensation of pyroglutamic acid , alanine and another amino acid component xxx ( xxx = gly , val , leu or gly-tyr ) preferentially yielded the dipeptide pyroglu-ala , but the formation of the tripeptide pyroglu-ala-ala became strongly reduced because of competing reactions . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
58,
68
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
235,
238
]
} |
heparin anticoagulant activity estimated by the aptt disappeared faster than heparin anticoagulant activity estimated by the anti-xa activity in the first phase . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
0,
7
]
} | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
125,
132
]
} |
after the same procedure of incubation the production of volatile alkanes ( pentane , ethane , ethylene , n-butane , and propane ) was estimated by gas chromatography . | NA | {
"id": "C0002065",
"name": "alkanes",
"pos": [
66,
73
]
} | {
"id": "C0014969",
"name": "ethane",
"pos": [
86,
92
]
} |
after the same procedure of incubation the production of volatile alkanes ( pentane , ethane , ethylene , n-butane , and propane ) was estimated by gas chromatography . | NA | {
"id": "C0002065",
"name": "alkanes",
"pos": [
66,
73
]
} | {
"id": "C0033434",
"name": "propane",
"pos": [
121,
128
]
} |
cultures wer made from thawed skin and growing cells were found to contain epithelial-like or fibroblast-like elements . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
47,
52
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
94,
104
]
} |
1 leukotriene c4 ( ltc4 ) , ltd4 , slow-reacting substance of anaphylaxis ( srs-a ) ( from guinea-pig lung ) , bradykinin ( bk ) and arachidonic acid ( aa ) release thromboxane a2 ( txa2 ) and prostaglandin-like materials from guinea-pig isolated perfused lungs . | NA | {
"id": "C0023542",
"name": "leukotriene c4",
"pos": [
2,
16
]
} | {
"id": "C0038091",
"name": "slow-reacting substance of anaphylaxis",
"pos": [
35,
73
]
} |
1 leukotriene c4 ( ltc4 ) , ltd4 , slow-reacting substance of anaphylaxis ( srs-a ) ( from guinea-pig lung ) , bradykinin ( bk ) and arachidonic acid ( aa ) release thromboxane a2 ( txa2 ) and prostaglandin-like materials from guinea-pig isolated perfused lungs . | NA | {
"id": "C0023544",
"name": "ltd4",
"pos": [
28,
32
]
} | {
"id": "C0038091",
"name": "slow-reacting substance of anaphylaxis",
"pos": [
35,
73
]
} |
6 fpl 55712 ( 1.9 microm ) , the srs-a antagonist , blocks contractions of gpps induced by ltc4 and ltd4 but not those due to ltb4 or bk . | NA | {
"id": "C0038091",
"name": "srs-a",
"pos": [
33,
38
]
} | {
"id": "C0023542",
"name": "ltc4",
"pos": [
91,
95
]
} |
6 fpl 55712 ( 1.9 microm ) , the srs-a antagonist , blocks contractions of gpps induced by ltc4 and ltd4 but not those due to ltb4 or bk . | NA | {
"id": "C0038091",
"name": "srs-a",
"pos": [
33,
38
]
} | {
"id": "C0023544",
"name": "ltd4",
"pos": [
100,
104
]
} |
the competitive affinity of adrenaline and noradrenaline determined by inhibition of [ 3h ] -dihydroergocryptine binding , was unchanged in the presence of either cation . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
28,
38
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
43,
56
]
} |
5 addition of the purine nucleotides adp , atp , gdp or gtp ( final concentration 10 microm ) , either alone or in the presence of 1 mm ca2+ or 1 mm mg2+ , had no effect on the binding of [ 3h ] -dihydroergocryptine or on the competitive affinity of adrenaline or noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
250,
260
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
264,
277
]
} |
1 the effects of leu-enkephalin , met-enkephalin and morphine on excitatory junction potentials ( e.j.ps ) and inhibitory junction potentials ( i.j.ps ) elicited by stimulation of efferent parasympathetic nerves were studied in cats and rabbits , anaesthetized and in vitro.2 enkephalins ( 0.008 mg/kg in vivo and 10 ( -... | NA | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
17,
31
]
} | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
276,
287
]
} |
1 the effects of leu-enkephalin , met-enkephalin and morphine on excitatory junction potentials ( e.j.ps ) and inhibitory junction potentials ( i.j.ps ) elicited by stimulation of efferent parasympathetic nerves were studied in cats and rabbits , anaesthetized and in vitro.2 enkephalins ( 0.008 mg/kg in vivo and 10 ( -... | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
34,
48
]
} | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
276,
287
]
} |
1 in homogenates of rat brain , the binding characteristics of tritiated opiates and opioid peptides were examined and the relative capacities of mu- , delta- and kappa-binding sites of the opiate receptor determined by saturation analysis.2 in competition experiments , binding of the selective mu-ligand [ ( 3 ) h ] - ... | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
85,
100
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
717,
727
]
} |
sacroiliac uptake ratios based on 99tcm methylene diphosphonate images were calculated in 14 patients with ankylosing spondylitis , 23 patients with non-specific backache , 33 patients with inflammatory bowel disease ( ulcerative colitis 19 , crohn 's disease 14 ) and 33 control subjects . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
190,
216
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
243,
259
]
} |
if extended to human insulin and different hla-dr and hla-b antigen patterns , these finding should help in the therapeutic selection of the appropriate insulin and thus reduce the induction of an anti-insulin response in patients with diabetes . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
15,
28
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
202,
209
]
} |
after an earlier study into the practical aspects of the management of perinatal death , a counselling service was introduced for parents whose baby had died in the perinatal period . | NA | {
"id": "C0701826",
"name": "perinatal",
"pos": [
71,
80
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
153,
157
]
} |
the specific , high affinity uptake of [ 3h ] dopamine by dopaminergic nerve terminals was studied in a synaptosomal preparation by pharmacological exclusion , using desmethylimipramine , of dopamine uptake into other monoaminergic nerve terminals . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
46,
54
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
58,
70
]
} |
the data of this study provide evidence for a further mechanism by which beta-endorphin may alter dopaminergic neurotransmission , namely by increasing dopamine reuptake into dopaminergic nerve endings . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
98,
106
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
175,
187
]
} |
with 3 proteases of different substrate specificities ( trypsin , chymotrypsin and s. griseus protease ) smooth microsomal opiate receptors from rat brain were consistently less sensitive to limited proteolysis than were synaptic membrane receptors . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
7,
16
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
94,
102
]
} |
regional concentrations of noradrenaline and dopamine in the frontal cortex of the rat : dopaminergic innervation of the prefrontal subareas and lateralization of prefrontal dopamine . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
89,
101
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
174,
182
]
} |
this factor also induced dna synthesis in glioma cells ( 354a and lrm55 ) and fibroblast ( swiss 3t3 ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
49,
54
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
78,
88
]
} |
receptor affinities of these various opiate/opioid drugs suggest that these two actions are mediated by different receptors which appear not to include high affinity mu receptors . | NA | {
"id": "C0034801",
"name": "receptor",
"pos": [
0,
8
]
} | {
"id": "C0066908",
"name": "mu receptors",
"pos": [
166,
178
]
} |
mdp is the smallest active component of peptidoglycan , whereas lps is the active component of endotoxin . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
64,
67
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
95,
104
]
} |
the increase in plasma epinephrine parallelled the increase in heart rate and cardiac output , and the decrease in plasma norepinephrine paralleled the decrease in systemic vascular resistance . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
23,
34
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
122,
136
]
} |
characterization of indicator bacteria in municipal raw water , drinking water , and new main water samples . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
56,
61
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
64,
78
]
} |
in four years , 11 514 bacterial cultures were isolated from either raw water , drinking water , or new main water samples submitted to three environmental laboratories . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
72,
77
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
80,
94
]
} |
bulk dna and dna extracted by methods which increase the yield of circular dna moieties were analyzed by cesium chloride and cesium chloride -- ethidium bromide buoyant density ultracentrifugation and by horizontal and vertical agarose gel electrophoresis . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
5,
8
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
66,
78
]
} |
analysis of acid esterase activity and polymorphism as an aid for the classification of human low-grade malignant non-hodgkin 's lymphomas . | NA | {
"id": "C0079747",
"name": "low-grade malignant",
"pos": [
94,
113
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
114,
128
]
} |
six of these were classical neuroblastomas while the other three exhibited olfactory differentiation in addition to the classical neuroblastoma component . | NA | {
"id": "C0027819",
"name": "neuroblastomas",
"pos": [
28,
42
]
} | {
"id": "C0206717",
"name": "olfactory",
"pos": [
75,
84
]
} |
edxa studies demonstrated an amphibole core in 88 of the 90 asbestos bodies ( amosite or crocidolite in 80 of 88 , anthophyllite or tremolite in eight of 88 ) , and chrysotile in two instances . | NA | {
"id": "C0206121",
"name": "amphibole",
"pos": [
29,
38
]
} | {
"id": "C0051740",
"name": "amosite",
"pos": [
78,
85
]
} |
edxa studies demonstrated an amphibole core in 88 of the 90 asbestos bodies ( amosite or crocidolite in 80 of 88 , anthophyllite or tremolite in eight of 88 ) , and chrysotile in two instances . | NA | {
"id": "C0206121",
"name": "amphibole",
"pos": [
29,
38
]
} | {
"id": "C0056502",
"name": "crocidolite",
"pos": [
89,
100
]
} |
immunization of high risk populations with the hepatitis b vaccine and prevention of mother-to-child transmission of hbv with hepatitis b immunoglobulin should prevent the development of chronic hepatitis b infection and , therefore , should also prevent the development of hepatocellular carcinoma . | NA | {
"id": "C0019163",
"name": "hbv",
"pos": [
117,
120
]
} | {
"id": "C0524909",
"name": "chronic hepatitis b",
"pos": [
187,
206
]
} |
cytogenetic , morphologic , and clinical data of 33 acute nonlymphocytic leukemia ( anll ) patients with t ( 8q - ; 21q+ ) and 19 patients with acute promyelocytic leukemia ( apl ) were collected from seven laboratories in japan . | NA | {
"id": "C0023467",
"name": "acute nonlymphocytic leukemia",
"pos": [
52,
81
]
} | {
"id": "C0023487",
"name": "acute promyelocytic",
"pos": [
144,
163
]
} |
the t ( 8q - ; 21q+ ) and t ( 15q + ; 17q- ) translocations were each shown to be associated with a specific type of anll , namely , aml-m2 and apl-m3 , respectively . | NA | {
"id": "C0023467",
"name": "aml",
"pos": [
133,
136
]
} | {
"id": "C0023487",
"name": "apl",
"pos": [
144,
147
]
} |
at saturation density in culture , the cell surface glycosaminoglycan of c1-s1 cells was approximately 80 % heparan sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
52,
69
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
108,
123
]
} |
methylation reactions carried out with mammalian transfer rna ( trna ) methyltransferases and rna prepared from the homologous source do not normally show significant incorporation of methyl groups into the trna . | NA | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
49,
61
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
208,
211
]
} |
methylation of tumor rna eluted from polyacrylamide gels after separation by electrophoresis indicated that while methyl-accepting material is found throughout the rna-containing region of the gel , rnas migrating slower than the bulk of mature trna are particularly good substrates for adenine methyltransferase . | NA | {
"id": "C0035699",
"name": "tumor rna",
"pos": [
15,
24
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
246,
249
]
} |
anchorage-independent growth promotion , however , is not seen with normal mammary epithelial cells , although mtf is mitogenic for these cells as well as normal rat kidney cells , balb/c-3t3 cells , and chick embryo fibroblasts in monolayer culture , mtf is not mitogenic for primary cultures of the tumor cells from wh... | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
68,
74
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
217,
228
]
} |
these lines , uct-mel 1 and uct-mel 2 , were used to study the effects of retinoic acid and other derivatives of vitamin a . | NA | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
74,
87
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
113,
122
]
} |
histologic diagnosis included 11 gliomas , seven ependymomas , one dysgerminoma , one teratocarcinoma , one pinealoma , and one small cell tumor . | NA | {
"id": "C0017638",
"name": "gliomas",
"pos": [
33,
40
]
} | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
49,
60
]
} |
the effects of 4'epi-doxorubicin ( 4'-epi-dx ) on survival of in situ murine bone marrow hematopoietic precursor cells ( hpc ) were studied . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
21,
32
]
} | {
"id": "C0014582",
"name": "4",
"pos": [
35,
36
]
} |
the cells released both epinephrine and norepinephrine in response to stimulation by 100 microm acetylcholine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
24,
35
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
40,
54
]
} |
the ratio of epinephrine to norepinephrine in the medium following non-stimulated ( basal ) release , was similar to that found in the intact cells . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
13,
24
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
28,
42
]
} |
on the other hand , a lower ratio of epinephrine to norepinephrine was found in the medium following stimulation by acetylcholine due mainly to preferential secretion of norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
37,
48
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
170,
184
]
} |
the dna insertions that cause the highly unstable mutations wc and wdzl share extensive homology with the fb family of transposable elements . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
4,
7
]
} | {
"id": "C0012868",
"name": "transposable elements",
"pos": [
119,
140
]
} |
a portion ( the u3 region ) of the long terminal repeat of fsv dna appears to be unusual among avian retroviruses in its close similarity in sequence and overall organization to the same region of the endogenous viral ev1 dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
63,
66
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
212,
217
]
} |
to maintain blood levels of antibiotics known to be effective in the treatment of chlamydial infections with a dosage schedule possible in a trachoma control programme , one of the long-acting tetracyclines ( doxycycline or minocycline ) might be considered . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
193,
206
]
} | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
209,
220
]
} |
to maintain blood levels of antibiotics known to be effective in the treatment of chlamydial infections with a dosage schedule possible in a trachoma control programme , one of the long-acting tetracyclines ( doxycycline or minocycline ) might be considered . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
193,
206
]
} | {
"id": "C0026187",
"name": "minocycline",
"pos": [
224,
235
]
} |
these data suggest that use of surface water is important in the transmission of v. cholerae and that , in addition to providing safe drinking water , education regarding the risk of transmission of infection by water from potentially contaminated sources used for other purposes , especially bathing , may also be neces... | NA | {
"id": "C0043047",
"name": "water",
"pos": [
39,
44
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
134,
148
]
} |
chagas ' disease is an endemic human trypanosomiasis produced by trypanosoma cruzi , which is usually transmitted by blood-sucking triatomid bugs . | NA | {
"id": "C0041234",
"name": "chagas",
"pos": [
0,
6
]
} | {
"id": "C0041227",
"name": "trypanosomiasis",
"pos": [
37,
52
]
} |
prednimustine , an ester of chlorambucil and prednisolone , was evaluated for efficacy and toxicity in a selected group of leukemia patients with a poor prognosis . | NA | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
0,
13
]
} | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
28,
40
]
} |
we have found that high-resolution two-dimensional gel electrophoretic analysis of nuclear proteins is a valuable technique for studying the effects of cytotoxic agents on the synthesis and/or extractability of specific cellular proteins . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
83,
99
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
229,
237
]
} |
the results indicate that the liver tumor promoting action of phb and of barbiturates is dependent upon biological effects related to the presence of an alkyl group in their side chain . | NA | {
"id": "C0031412",
"name": "phb",
"pos": [
62,
65
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
73,
85
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.