text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the transcript was characterized rigorously by two-dimensional separation and analysis of the oligonucleotides formed on digestion with t1-rnase and pancreatic rnase and by nearest neighbor analyses of the oligonucleotides obtained when different alpha-32p-labeled ribonucleoside triphosphates were used as substrates . | NA | {
"id": "C0014241",
"name": "rnase",
"pos": [
139,
144
]
} | {
"id": "C0035541",
"name": "pancreatic rnase",
"pos": [
149,
165
]
} |
an examination of the base modifications of the primary transcript during treatment of the latter with e. coli s-100 extract showed couplete modification of uridine to pseudouridine and partial methylation of uridine to ribosylthymine in tpsicg sequence and partial formation of pseudouridine in the anticodon loop . | NA | {
"id": "C0033846",
"name": "pseudouridine",
"pos": [
168,
181
]
} | {
"id": "C0041984",
"name": "uridine",
"pos": [
285,
292
]
} |
in solutions whose sole anion is phosphate a 645 nm form is the only demonstrable spectral species . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
24,
29
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
33,
42
]
} |
the polymerase is unable to work at nicks or at short gaps of approximately 20 to 30 nucleotides in length , and it measures a surprisingly invariant effective template length on optimally activated dna and on dna molecules that have been gapped to varying extents with escherichia coli exonuclease iii . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
11,
12
]
} | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
210,
223
]
} |
we conclude that bhk21/c13 cells contain both the fibroblast and the muscle form of 10 nm filament protein . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
27,
32
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
50,
60
]
} |
the formation of s-3-sulfopropylcysteine in proteins and the subsequent hydrolysis of the proteins with methanesulfonic acid are particularly useful for complete amino acid analysis at the picomole level using a single sample . | NA | {
"id": "C0034861",
"name": "formation",
"pos": [
4,
13
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
90,
98
]
} |
escherichia coli heat-labile enterotoxin ( labile toxin , lt ) catalyzed the hydrolysis of nad to adp-ribose and nicotinamide and the adp-ribosylation of arginine ( moss , j. , and richardson , s.h . ( 1978 ) j. clin . invest . 62 , 281-285 ) . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
29,
40
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
50,
55
]
} |
this result is consistent with the covalent attachment by the enterotoxin of adp-ribose rather than poly ( adp-ribose ) to protein . | NA | {
"id": "C0001461",
"name": "adp-ribose",
"pos": [
77,
87
]
} | {
"id": "C0032403",
"name": "poly ( adp-ribose",
"pos": [
100,
117
]
} |
factor ixa beta , the ultimate activation product of factor ix , in the intrinsic system , likewise contains at least two strong ca2+ sites , of average kd 0.1 mm , as well as seven additional weaker sites , possessing an average kd of 1.0 mm . | NA | {
"id": "C0015494",
"name": "factor ixa",
"pos": [
0,
10
]
} | {
"id": "C0015491",
"name": "factor",
"pos": [
53,
59
]
} |
the results revealed that cholesterol nitrate , cholesterol phosphate , and a series of acyl esters of cholesterol can also be cleaved by the enzyme system to their respective pregnenolone derivatives without first being hydrolyzed to cholesterol . | NA | {
"id": "C0008387",
"name": "esters",
"pos": [
93,
99
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
235,
246
]
} |
this conclusion was based on the fact that 1 ) both radiolabeled l-proline and trans-4-hydroxy-l-proline are precursors of the bound d-imino acid as noted previously by hook and vining ( ( 1973 ) j. chem . soc . chem . commun . 185-186 ; ( 1973 ) can . j. biochem . 51 , 1630-1637 ) , 2 ) the unlabeled trans isomer spec... | NA | {
"id": "C0020931",
"name": "imino acid",
"pos": [
135,
145
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
526,
533
]
} |
the major polypeptide chain present ( 58,000 daltons ) is shown to cosediment with a dna-dependent gtpase ( and atpase ) activity , and to induce extensive in vitro dna synthesis on both single- and double-stranded dna templates when incubated with our preparations of five other purified t4 dna replication proteins ( p... | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
83,
88
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
199,
218
]
} |
same doses of epinephrine and norepinephrine ( which correspond to a slight hypercatecholamine blood level under stress ) are injected intravenously , comparatively before and after lumbar sympathectomy . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
14,
25
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
30,
44
]
} |
the gh dependency of somatomedin ( sm ) peptide content in plasma was assessed using the placental membrane radioreceptor assay ( rra ) to measure whole and acid-chromatographed plasma using both [ 125i ] sm a and [ 125i ] sm c . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
21,
32
]
} | {
"id": "C0021666",
"name": "sm a",
"pos": [
205,
209
]
} |
the gh dependency of somatomedin ( sm ) peptide content in plasma was assessed using the placental membrane radioreceptor assay ( rra ) to measure whole and acid-chromatographed plasma using both [ 125i ] sm a and [ 125i ] sm c . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
21,
32
]
} | {
"id": "C0021665",
"name": "sm c",
"pos": [
223,
227
]
} |
on the first day of collection , the major radiolabeled metabolites were 21-hydroxylated steroids ( e.g . allo-tetrahydrocorticosterone and 5 alpha- and beta-pregnane-3 alpha,11 beta,20 alpha,21-tetrol ) , but by the third day , at least 75 % of the excreted activity was associated with 21-deoxysteroids , such as 3 alp... | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
89,
97
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
401,
409
]
} |
thyrotropin : alpha- and beta-subunits of thyrotropin , and prolactin responses to four-hour constant infusions of thyrotropin-releasing hormone in normal subjects and patients with pituitary-thyroid disorders . | NA | {
"id": "C0076641",
"name": "beta-subunits",
"pos": [
25,
38
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
115,
126
]
} |
by contrast , transient elevations in pregnenolone and 17-hydroxypregnenolone levels probably corresponded to the nomral morning rise in plasma levels of these steroids ; | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
38,
50
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
55,
77
]
} |
effect of intravenous cortisol infusion on maternal concentrations of estriol , 16 alpha-hydroxyprogesterone , 17 alpha-hydroxyprogesterone , progesterone , 20 alpha-dihydroprogesterone , delta 5-pregnenolone , delta5-pregnenolone sulfate , dehydroepiandrosterone sulfate , and cortisol . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
96,
108
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
157,
185
]
} |
maternal concentrations of estriol , 16 alpha-hydroxyprogesterone , 17 alpha-hydroxyprogesterone , progesterone , 20 alpha-dihydroprogesterone , delta 5-pregnenolone , delta 5-pregnenolone sulfate , dehydroepiandrosterone sulfate , and cortisol were measured by ria before and at 8 and 12 h after iv cortisol infusions a... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
53,
65
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
114,
142
]
} |
binding of 125i-insulin by platelets was inhibited by unlabeled porcine insulin and to a lesser extent by catfish insulin and porcine proinsulin but not by glucagon , prolactin , growth hormone , and thrombin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
16,
23
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
134,
144
]
} |
among 14 amino acids measured in plasma of these patients , the concentrations of alanine , serine , ornithine , and arginine were significantly ( p < 0.05 ) elevated to approximately twice that of normal : alanine and serine are both substrates for gluconeogenesis , whereas ornithine and arginine are involved in the f... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
9,
20
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
207,
214
]
} |
the effects of continuous infusions of insulin in physiologic doses on glucose kinetics and circulating counterregulatory hormones ( epinephrine , norepinephrine , glucagon , cortisol , and growth hormone ) were determined in normal subjects and diabetics . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
133,
144
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
147,
161
]
} |
plasma norepinephrine and glucagon failed to rise during the insulin infusion , whereas plasma epinephrine , cortisol , and growth hormone rose to values comparable to controls receiving the same insulin dose . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
7,
21
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
95,
106
]
} |
the following tests were within normal limits : platelet count , bleeding time , thrombin time , prothrombin time , partial thromboplastin time , titers of known clotting factors , platelet glass bead retention , factor viii-related antigen , platelet aggregation by adp , collagen and ristocetin , and clot retraction . | NA | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
162,
178
]
} | {
"id": "C0042971",
"name": "factor",
"pos": [
213,
219
]
} |
a human neutrophil neutral protease which generates a low molecular weight peptide from a plasma protein substrate and cleaves the basic amino acid ester substrates alpha-n-p-tosyl-l-arginine methyl ester hcl , alpha-n-benzoyl-l-arginine-methyl ester hcl , and alpha-n-carbobenzoxy-l-lysine-p-nitrophenyl ester has been ... | NA | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
131,
147
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
284,
290
]
} |
arterial plasma concentrations of norepinephrine and epinephrine , measured by a single isotopic radioenzymatic assay , rose ( from 117.9 +/- 6.7 to 201.8 +/- 13.3 pg/ml , p less than 0.001 ; and from 71.6 +/- 4.5 to 124.1 +/- 8.4 pg/ml , p less than 0.001 , respectively ) during nicotine infusion . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
34,
48
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
53,
64
]
} |
mitogen-activated suppressor cells were simultaneously assayed for their ability to inhibit ( a ) pokeweed mitogen-induced generation of plasma cells , ( b ) blastogenic response of lymphocytes to allogeneic cells , and ( c ) generation of killer cells in the cell-mediated lymphocytotoxicity assay . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
197,
213
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
260,
264
]
} |
when added alone in concentrations ranging between 10 nm and 0.1 mm , the adrenergic agonists , epinephrine and norepinephrine , had no effect on cle accumulation . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
96,
107
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
112,
126
]
} |
however , the effect of t ( 3 ) was clearly potentiated by the concomitant addition of epinephrine , norepinephrine , and possibly isoproterenol , whereas terbutaline and phenylephrine were without effect . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
87,
98
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
101,
115
]
} |
their possible participation in the sequence of events leading from the biosynthesis and conversion of proinsulin to the release of newly synthesized insulin was investigated in rat isolated islets exposed to colchicine ( 0.1 mm ) . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
103,
113
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
150,
157
]
} |
in fasting nonpregnant animals , urinary norepinephrine ( ne ) excretion decreases and epinephrine ( e ) excretion remains unchanged , whereas the excretion of both catecholamines rises significantly with refeeding . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
41,
55
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
87,
98
]
} |
small chylomicrons ( cm ) labeled with cholesterol , cholesterol ester , phospholipid , and , in some cases , protein , were used to study the fate of these constituents as the cm are catabolized in the circulations of the hepatectomized and intact rat . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
39,
50
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
53,
70
]
} |
compared to the injected cm , the chemically altered particles , called cm `` '' remnants , '' '' have a reduction in volume of 96 % and in surface area of 88 % . | NA | {
"id": "C0008731",
"name": "cm",
"pos": [
25,
27
]
} | {
"id": "C0443616",
"name": "cm",
"pos": [
72,
74
]
} |
the labeled cholesterol esters remain with the cm remnants but , strikingly , a major fraction of the labeled phospholipids and labeled soluble apoproteins leave the cm and are found in the high density lipoprotein ( hdl ) fraction . | NA | {
"id": "C0443616",
"name": "cm remnants",
"pos": [
47,
58
]
} | {
"id": "C0008731",
"name": "cm",
"pos": [
166,
168
]
} |
thyroid disease is often accompanied by changes in the concentrations of serum lipids and lipoproteins . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
79,
85
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
90,
102
]
} |
to evaluate the hepatic contribution to the serum abnormalities in thyroid disease , we examined fatty acid metabolism in perfused livers from pair-fed rats made hypothyroid with propylthiouracil ( ptu ) or made hyperthyroid by treatment with triiodothyronine ( t ( 3 ) ) . | NA | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
67,
82
]
} | {
"id": "C0020676",
"name": "hypothyroid",
"pos": [
162,
173
]
} |
to evaluate the hepatic contribution to the serum abnormalities in thyroid disease , we examined fatty acid metabolism in perfused livers from pair-fed rats made hypothyroid with propylthiouracil ( ptu ) or made hyperthyroid by treatment with triiodothyronine ( t ( 3 ) ) . | NA | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
67,
82
]
} | {
"id": "C0020550",
"name": "hyperthyroid",
"pos": [
212,
224
]
} |
in this study , we detected dna : anti-dna compexes by identification of both the antigen and ( or ) the antibody , the necessary requisites for immune complex definition , in 14 of 24 plasmas ( 7 of 11 patients ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
105,
113
]
} | {
"id": "C0003313",
"name": "immune",
"pos": [
145,
151
]
} |
these antibodies were specific for native dna and could be adsorbed by anti-immunoglobulin ( ig ) g antisera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
6,
16
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
100,
108
]
} |
the lack of correlation with other methods of detection of immune complexes and with the presence of heavy igg ( above 13 s ) is in favor of the existence of other antigen-antibody systems ( or aggregated immunoglobulins ) in systemic lupus erythematosus plasmas . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
59,
75
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
172,
180
]
} |
bovine parathyroid hormone stimulated the 1- and reduced the 24-hydroxylase in 6 h , but this only occurred in cultures either previously treated with 1,25 ( oh ) 2d3 and egta to lower ca to 0.8 mm or in cultures grown in the presence of 25-hydroxyvitamin d3 ( 25 ( oh ) d3 ) . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
238,
258
]
} | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
261,
273
]
} |
these in vitro studies suggest a direct inhibitory role for dopamine on the late phase of aldosterone biosynthesis , which may account for the in vivo inhibition of the aldosterone response to angiotensin in subjects treated with a dopaminergic agent . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
60,
68
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
232,
244
]
} |
during the first 6-12 h , intracellular labeled glycosaminoglycans accumulated in the dominant dystrophic epidermolysis bullosa cells at about twice the rate as that of control fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
128,
133
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
177,
188
]
} |
neutrophils were sensitized for 30 min at 22 degrees c with antibodies from three patients with antineutrophil autoantibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
60,
70
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
111,
125
]
} |
when erythrocytes from cord blood and from hbc and sickle cell anemia patients were incubated with elevated concentrations of glucose , fetal hb , hbc , and sickle hb decreased , whereas hemoglobins focusing at isoelectric points near those expected for the corresponding glycosylated derivatives appeared in proportiona... | NA | {
"id": "C0015936",
"name": "fetal hb",
"pos": [
136,
144
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
187,
198
]
} |
a patient with lambda bence-jones proteinuria , waldenstrom 's macroglobulinaemia , and franklin 's disease ( gamma hcd ) , but without clinical evidence of a lymphoproliferative disorder , is presented . | NA | {
"id": "C0024419",
"name": "waldenstrom 's macroglobulinaemia",
"pos": [
48,
81
]
} | {
"id": "C0024314",
"name": "lymphoproliferative disorder",
"pos": [
159,
187
]
} |
the prevalence of viral antibodies with the exception of antibody to hepatitis b surface antigen ( anti-hbs ) and cytomegalovirus ( cmv ) was normal when compared to that in the general population . | NA | {
"id": "C0003253",
"name": "viral antibodies",
"pos": [
18,
34
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
57,
65
]
} |
to test whether this correlation was causal , central catecholamines were increased by the intraperitoneal administration of l-3,4-dihydroxyphenylalanine ( l-dopa ) , 10 -- 40 mg/kg ) after inhibition of extracerebral l-amino acid decarboxylase . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
54,
68
]
} | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
131,
153
]
} |
pretreatment with the catecholamine antagonist chlorpromazine ( 1 -- 2 mg/kg ) blocked the increase in locomotor exploration and investigation produced by l-dopa in 6-hydroxydopamine rats . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
22,
35
]
} | {
"id": "C0013023",
"name": "l-dopa",
"pos": [
155,
161
]
} |
the results suggest , but do not prove , that l-dopa produced these behavioral effects by increasing central catecholamines at the denervated catecholamine receptor sites in the forebrain . | NA | {
"id": "C0013023",
"name": "l-dopa",
"pos": [
46,
52
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
109,
123
]
} |
d-ascorbic acid ( daa ) and dehydroascorbic acid ( dhaa ) were also equally active in enhancing cgmp concentrations but metabolic precursors of ascorbic acid and other inorganic acids did not increase cgmp levels . | NA | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
28,
48
]
} | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
144,
157
]
} |
determination of the amount of dhaa contaminating the laa precluded the possibility that it was solely responsible for the enhanced cgmp levels . | NA | {
"id": "C0011177",
"name": "dhaa",
"pos": [
31,
35
]
} | {
"id": "C0003968",
"name": "laa",
"pos": [
54,
57
]
} |
in broken cell preparations , laa , daa , and dhaa and to a lesser extent sodium ascorbate ( naa ) enhanced guanylate cyclase activity while neither inhibited camp or cgmp phosphodiesterase ( pde ) activity . | NA | {
"id": "C0003968",
"name": "daa",
"pos": [
36,
39
]
} | {
"id": "C0011177",
"name": "dhaa",
"pos": [
46,
50
]
} |
in broken cell preparations , laa , daa , and dhaa and to a lesser extent sodium ascorbate ( naa ) enhanced guanylate cyclase activity while neither inhibited camp or cgmp phosphodiesterase ( pde ) activity . | NA | {
"id": "C0003968",
"name": "daa",
"pos": [
36,
39
]
} | {
"id": "C0887557",
"name": "sodium ascorbate",
"pos": [
74,
90
]
} |
in desensitized cells that were subsequently washed free of catecholamine , the decrement in isoproterenol-stimulated adenylate cyclase activity and the decrease in the capacity of isoproterenol to inhibit 125ihyp binding returned to control levels within 15 min . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
60,
73
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
181,
194
]
} |
besides generally studied glutamate oxalacetate transaminase and glutamate pyruvate transaminase , a large number of other microbial transaminases also have been detected in the rumen of both the ruminant species . | NA | {
"id": "C0001899",
"name": "glutamate pyruvate transaminase",
"pos": [
65,
96
]
} | {
"id": "C0002594",
"name": "transaminases",
"pos": [
133,
146
]
} |
the chloride corrosion behavior of five silver-palladium dental casting alloys was investigated in a 1 % nacl solution through the use of electrochemical hysteresis technique . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
4,
12
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
105,
109
]
} |
after digestion with collagenase , the resulting phosphoprotein fraction still contained a few residues of hydroxyproline and hydroxylysine , and an enhanced content of proline , compared to the equivalent directly extractable phosphophoryn of the matrix . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
107,
121
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
169,
176
]
} |
there was no consistent relationship between reactivity to ganoderma antigen and any of the common inhaled allergens . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
69,
76
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
107,
116
]
} |
the findings indicate that ganoderma antigen is commonly encountered , can induce human sensitization , and has unique antigenicity among common allergens of clinical importance . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
37,
44
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
145,
154
]
} |
immunocytochemical localizations of carbonic anhydrase isozymes i and ii in different histologic sites , by means of affinity column purified antibodies , agreed with the distribution of these enzymes in the various sites , as indicated by immunologic assays . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
55,
63
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
193,
200
]
} |
the specificity of the immunological localization for each antigen was confirmed by testing with specific antisera following absorption with homologous and heterologous antigens . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
59,
66
]
} | {
"id": "C0003333",
"name": "heterologous antigens",
"pos": [
156,
177
]
} |
the results indicated that antigenic determinants of rat prolactin and growth hormone were not completely destroyed or inactivated by fixation with osmium and embedment in epoxy resin , and that removal of the polymerized epoxy resin was necessary to obtain light microscopic postembedding immunocytochemical staining of... | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
27,
49
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
327,
335
]
} |
in addition , we demonstrate that antibodies of the igm , igg1 , and igg2 immunoglobulin classes express the cgat idiotype . | NA | {
"id": "C0020861",
"name": "antibodies",
"pos": [
34,
44
]
} | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
74,
96
]
} |
in principle , the 125i staph a assay may be applied ot igg quantitation for crude allergen extracts as well as purified antigens . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
83,
91
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
121,
129
]
} |
precursor cells for the two suppressor systems investigated belong to the short-lived cortical thymus cell population . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
0,
15
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
102,
106
]
} |
the kinetics of appearance of the precursors of suppa cells ( capable of inhibiting ctlp leads to ctl ) or suppb cells ( capable of inhibiting ( stem cells leads to ctlp ) in neonatal mice , as well as the appearance of suppa/suppb cells in mice given neonatal innoculations of semiallogeneic spleen cells has been inves... | NA | {
"id": "C0018956",
"name": "precursors",
"pos": [
34,
44
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
300,
305
]
} |
the results of these studies support our previous observations that activation of the alternative c pathway is required for platelet lysis and that preparations of lps that activate only the classical pathway ( e.g. , lipid a ) do not cause lysis . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
164,
167
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
218,
225
]
} |
on the basis of a number of experiments , including inhibition with polymyxin b , treatment of lps with alkali , and blocking experiments with polysaccharide-free lps preparations , it is concluded that the lipid a region of the lps molecule is responsible for attaching the lps to the platelet . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
207,
214
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
275,
278
]
} |
finally , a comparison of the activity of lipid a-associated protein-lps complexes with protein-free lps demonstrated that an equivalent extent of platelet lysis was achieved with one-one hundredth the concentration of the former as that required for protein-free lps . | NA | {
"id": "C0023767",
"name": "a",
"pos": [
3,
4
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
264,
267
]
} |
these two idiotypes were detected by lewis rat anti-idiotypic antisera prepared against affinity-purified a/j and sjl antinuclease antibodies , termed the a/j and sjl idiotypes , respectively . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
62,
70
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
131,
141
]
} |
the larger , carboxyl terminal polypeptides bound efficiently to homologous antiserum but about two orders of magnitude less efficiently to heterologous antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
76,
85
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
153,
161
]
} |
endotoxin protein , an outer membrane protein of gram-negative bacteria associated with lipopolysaccharide endotoxin , has been found to be a potent activator of lymphocytes . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
88,
106
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
107,
116
]
} |
this stimulation is greater than that obtained with two well known murine b cell activators , lipopolysaccharide endotoxin or ppd-tuberculin . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
94,
112
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
113,
122
]
} |
antiserum absorption experiments , two-stage cytotoxicity assays , and results of immunoprecipitations performed after prebinding antibody to radiolabeled thymocytes suggest that some t100 is accessible to antibody on the intact cell surface . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
0,
9
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
206,
214
]
} |
spleen cells from athymic nu/nu mice contain two kinds of physically separable active cells that can have very different effects on the generation of cl ( cytotoxic lymphocytes ) by normal ln cells in an in vitro response against allogeneic stimulator cells . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
182,
188
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
230,
240
]
} |
in cells prelabeled with [ 14c ] arachidonic acid , phytohemagglutinin ( pha ) produced substantial ( 3.5- to 12-fold ) increases in 5-hete , 12-hete , and tb2 radiolabeling . | NA | {
"id": "C0020349",
"name": "hete",
"pos": [
135,
139
]
} | {
"id": "C0044800",
"name": "12-hete",
"pos": [
142,
149
]
} |
these findings indicate that a non-t cell , presumably a b cell , is capable of recognizing the carrier epitopes of this thymus-independent hapten-carrier complex . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
104,
112
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
140,
146
]
} |
in addition , acid and heat lability of pglc-33h if suggested similarity to type ii if . | NA | {
"id": "C0021747",
"name": "if",
"pos": [
49,
51
]
} | {
"id": "C0021745",
"name": "type ii if",
"pos": [
76,
86
]
} |
moreover , co-culture with allogeneic cells did not affect the net tnp-conjugate proliferative responses of primed responder cells , suggesting that hla-d region preference was due to a requirement for representation of tnp-molecules in association or combination with autologous mhc structures . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
27,
43
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
59,
62
]
} |
sensitization of human lymphocytes to allogeneic cells alone did not prime responses to autologous modified cells . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
38,
54
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
108,
113
]
} |
the results of a comparative idiotypic analysis of multiple ig paraproteins isolated from the serum of an individual patient , ca , with sjogren 's syndrome and waldenstrom 's macroglobulinemia are reported . | NA | {
"id": "C0021027",
"name": "ig",
"pos": [
60,
62
]
} | {
"id": "C0030490",
"name": "paraproteins",
"pos": [
63,
75
]
} |
this n-terminal sequence homology in the v-regions of cam igm kappa and igg kappa paraproteins and the shared idiotypy expressed by cam igm , igg , and iga proteins strongly suggest the existence of complete structural homology in the variable regions of the and l chains of these ig molecules of three separate ig class... | NA | {
"id": "C0030490",
"name": "paraproteins",
"pos": [
82,
94
]
} | {
"id": "C0021027",
"name": "ig",
"pos": [
312,
314
]
} |
the effector cells were neither macrophages nor b cells ( plastic and nylon-wool nonadherent ) and did not form e-rosettes with neuraminidase-treated sheep red blood cells . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
58,
65
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
70,
75
]
} |
the appearance of anti-malarial antibodies and malarial antigens in the serum was closely associated with a depression of c3 levels and the presence of cic . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
32,
42
]
} | {
"id": "C0003313",
"name": "cic",
"pos": [
152,
155
]
} |
3 ) the ribonuclease-resistant mitogenic activity in polynucleotide preparations has properties unlike those of lps or lipid a ; | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
112,
115
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
119,
126
]
} |
generation on infected fibroblasts of human t and non-t lymphocytes with specific cytotoxicity , influenced by histocompatibility , against measles virus-infected cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
23,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
163,
168
]
} |
induction of autoreactive cells by the preculture of human peripheral blood mononuclear cells with the autologous fresh plasma . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
26,
31
]
} | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
59,
75
]
} |
the nonparallel behavior of adcc and neutralizing antibodies suggests the heterogeneity of either the antigen involved or the mechanism of antibody production in the two antibody systems . | NA | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
37,
60
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
170,
178
]
} |
treatment of human lymphoblastoid cells with either phytohemagglutinin ( pha ) , concanavalin a , staphylococcus protein a , or polyinosinic acid-polycytidylic acid , in combination with 5-iodo-2 ' deoxyuridine ( iudr ) markedly increased the expression of epstein-barr virus ( ebv ) early antigen ( ea ) relative to iud... | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
198,
210
]
} | {
"id": "C0020811",
"name": "iudr",
"pos": [
317,
321
]
} |
there was no evidence that the anti-viral antibody response was impaired in steroid-treated mice since concentrations of neutralizing antibody in the circulation were normal . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
42,
50
]
} | {
"id": "C0475463",
"name": "neutralizing",
"pos": [
121,
133
]
} |
we conclude that alphamo sera detect almost exclusively viral antigens on lstra cells , and these antigens are almost exclusively virion env gene products . | NA | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
56,
70
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
98,
106
]
} |
since this reaction is defective in patients with cll and sle and the homologous mouse syngeneic mlc is defective in nzb mice , the failure of this t-b interaction may be related to the pathogenesis of certain lymphoproliferative and autoimmune disorders . | NA | {
"id": "C0024141",
"name": "sle",
"pos": [
58,
61
]
} | {
"id": "C0004364",
"name": "autoimmune disorders",
"pos": [
234,
254
]
} |
dicarboxylic acids from c8 to c14 are competitive inhibitors of tyrosinase in vitro , and here , the effect of a cream containing 15 % azelaic acid ( c9 ) on 3 cases of lentigo maligna is described . | NA | {
"id": "C0012063",
"name": "dicarboxylic acids",
"pos": [
0,
18
]
} | {
"id": "C0052761",
"name": "azelaic acid",
"pos": [
135,
147
]
} |
in order to trace the origins of age-dependent diseases to the cellular level , we studied cultured human fibroblasts from subjects with 3 discrete inherited disorders and normal controls of various ages . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
63,
71
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
106,
117
]
} |
there was a decreased response of progeric fibroblasts to insulin-like hormones , and in normal cells the response decreased as a function of the passage level and donor age . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
43,
54
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
89,
101
]
} |
an understanding of fibroblast aging in vitro may help us explain various concomitant phenomena of organismic aging such as diabetes mellitus , cell dropout , impaired hormone responsiveness , and increased atherothrombosis . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
20,
30
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
144,
148
]
} |
in this paper we report on in vitro cytogenetic and cell fusion studies that indicate cultured fibroblast-like cells derived from werner patients differ from cells of normal donors . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
95,
105
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
158,
163
]
} |
the effects in mice of oral treatment with amoxicillin , ampicillin , and oxytetracycline against an otherwise lethal intranasal infection with chlamydia trachomatis ( mouse pneumonitis ) were studied . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
43,
54
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
57,
67
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.