text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
if 14 oral treatments were given , these values were 1.6 mg/kg for amoxicillin , 12.7 mg/kg for ampicillin , and 12.3 mg/kg for oxytetracycline . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
67,
78
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
96,
106
]
} |
the accumulated lipids are disposed of in part as serum lipoprotein , resulting in moderate hyperlipemia . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
16,
22
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
56,
67
]
} |
translation in vivo and in vitro of proteins resembling apoproteins of rat plasma very low density lipoprotein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
36,
44
]
} | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
56,
67
]
} |
ribonucleic acid ( rna ) extracted from this immunoprecipitate contained species with polyadenylate ( poly [ a ] sequences characteristic of eukaryotic messenger rna ( mrna ) . | NA | {
"id": "C0035668",
"name": "ribonucleic acid",
"pos": [
0,
16
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
152,
165
]
} |
there is evidence that cytotoxicity is related to the phagocytic property of cells since non-phagocytic fibroblasts survive under conditions lethal to p388d1 cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
104,
115
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
158,
163
]
} |
a sensitive color reaction after two-dimensional tlc described earlier for zeranol determination in veal samples is proposed for the detection of the zeranol metabolite zearalanone and the mycotoxin zearalenone . | NA | {
"id": "C0043465",
"name": "zeranol",
"pos": [
75,
82
]
} | {
"id": "C0043454",
"name": "zearalenone",
"pos": [
199,
210
]
} |
the data suggest that zeranol is biotransformed in vitro to a less active estrogen which has a marked similarity to the mycotoxin zearalenone . | NA | {
"id": "C0043465",
"name": "zeranol",
"pos": [
22,
29
]
} | {
"id": "C0043454",
"name": "zearalenone",
"pos": [
130,
141
]
} |
thus , the clearance of malaria parasites is regulated by several elements of the immune system , in addition to levels of specific antimerozoite antibodies , including the amount of antibodies bound to reticulocytes , the presence of circulating immune complexes , and the degree of macrophage stimulation . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
146,
156
]
} | {
"id": "C0003313",
"name": "circulating immune complexes",
"pos": [
235,
263
]
} |
an extracellular product of group a streptococci which induces lymphocyte blastogenesis has been purified to homogeneity by deae-cellulose and cm-cellulose chromatography . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
124,
138
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
146,
155
]
} |
allotype suppressor t-cell ( ts ) populations that persist for the life of the animal arise in ( balb/c x sjl ) f ( 1 ) hybrids exposed perinatally to antibody to the paternal ( ig-1b ) allotype on igg ( 2a ) -isotype immunoglobulin h chains . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
151,
159
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
210,
217
]
} |
in this publication , we show that specific ig-1 allotype ts are induced by perinatal exposure to antisera which interfere with normal b-cell maturation , i.e. , by antibodies reactive with surface igm on immature precursors of igg ( 2a ) , memory cells . | NA | {
"id": "C0021006",
"name": "ig",
"pos": [
44,
46
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
165,
175
]
} |
in this publication , we show that specific ig-1 allotype ts are induced by perinatal exposure to antisera which interfere with normal b-cell maturation , i.e. , by antibodies reactive with surface igm on immature precursors of igg ( 2a ) , memory cells . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
98,
106
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
165,
175
]
} |
the direct measurement of the axoplasmic transport of individual rna species : transfer but not ribosomal rna is transported . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
65,
68
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
96,
109
]
} |
estimation of activity of the brush border disaccharidases ( sucrase , lactase , and maltase ( showed that the mean level of each enzyme did not differ significantly from control subjects . | NA | {
"id": "C0012610",
"name": "disaccharidases",
"pos": [
43,
58
]
} | {
"id": "C0038634",
"name": "sucrase",
"pos": [
61,
68
]
} |
csf ig components of restricted heterogeneity , i.e . oligoclonal bands and/or regional increases of gamma-globulins , were more frequent in patients with ( meningo- ) encephalitic or ( meningo- ) -myelitis/radiculitic disorders ( respectively 69 and 48 % ) than in subjects with meningitis or guillain-barre syndrome ( ... | NA | {
"id": "C0021027",
"name": "ig",
"pos": [
4,
6
]
} | {
"id": "C0017007",
"name": "gamma-globulins",
"pos": [
101,
116
]
} |
in the methionine plus arginine group , free amino acid analysis showed that free glutamine and glutamic acid content significantly decreased in liver while no differences were found in plasma . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
82,
91
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
96,
109
]
} |
since glutamine may play an important role in the formation of uric acid for chickens , the reduced amount of free glutamine and glutamic acid in the liver of cocks fed the diet suplemented with methionine plus arginine might account for the reduced excretion of uric acid , and therefore for the nitrogen sparing action... | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
6,
15
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
129,
142
]
} |
an additional study showed that asparagine , alanine , aspartic acid , cystine , glutamic acid , proline , tyrosine , serine and glycine can be classified as dispensable amino acids for the immature dog . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
45,
52
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
170,
181
]
} |
an additional study showed that asparagine , alanine , aspartic acid , cystine , glutamic acid , proline , tyrosine , serine and glycine can be classified as dispensable amino acids for the immature dog . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
129,
136
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
170,
181
]
} |
in two experiments , young rats were preconditioned with dietary cholesterol by : 1 ) nursing from dams with a high cholesterol milk or , 2 ) receiving 10 mg cholesterol dissolved in 0.5 ml of corn oil daily from 6 to 30 days of age . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
57,
76
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
158,
169
]
} |
in scorbutic guinea pigs fed an ascorbic acid-deficient diet for 18 days , the ascorbic acid contents of the liver and plasma were less than 4 % those of the control animals , while the content in the brain was about one-third that of the controls . | NA | {
"id": "C0036474",
"name": "scorbutic",
"pos": [
3,
12
]
} | {
"id": "C0003969",
"name": "ascorbic acid-deficient",
"pos": [
32,
55
]
} |
the absorption of glucose was also decreased in these infants , as shown by a reduced rise in blood sugar . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
18,
25
]
} | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
94,
105
]
} |
serologic evaluation revealed that the syndrome was accompanied by the presence of 3 autoantibodies -- cold-active hemagglutinin , immunoconglutinin , and antibody to fibrinogen/fibrin products . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
85,
99
]
} | {
"id": "C0063413",
"name": "immunoconglutinin",
"pos": [
131,
148
]
} |
the pattern of incorporation of radioactivity from 14c-fructose and 14c-mannose into intermediates of hexose metabolism was indistinguishable from that reported elsewhere for the initial post-absorptive metabolism of 14c-glucose under comparable conditions ; | NA | {
"id": "C0016745",
"name": "fructose",
"pos": [
55,
63
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
102,
108
]
} |
these hexoses were phosphorylated rapidly following their absorption , and much of the radioactivity absorbed as mannose or fructose was recovered in the nonreducing disaccharide trehalose [ alpha-d-glucopyranosyl- ( 1 leads to 1 ) -alpha-d-glucopyranoside ] . | NA | {
"id": "C0019494",
"name": "hexoses",
"pos": [
6,
13
]
} | {
"id": "C0024742",
"name": "mannose",
"pos": [
113,
120
]
} |
these hexoses were phosphorylated rapidly following their absorption , and much of the radioactivity absorbed as mannose or fructose was recovered in the nonreducing disaccharide trehalose [ alpha-d-glucopyranosyl- ( 1 leads to 1 ) -alpha-d-glucopyranoside ] . | NA | {
"id": "C0019494",
"name": "hexoses",
"pos": [
6,
13
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
124,
132
]
} |
the extensive incorporation of hexose moieties into trehalose or a trehalose-like disaccharide rather than glycogen underscores the probable importance of trehalose metabolism to carbohydrate assimilation in moniliformis . | NA | {
"id": "C0040815",
"name": "trehalose",
"pos": [
52,
61
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
82,
94
]
} |
synchronous growth of both the htc and fibroblast cultures occurred after removal of drug as indicated by the sequence of changes in [ 3h ] thymidine incorporation into dna , cellular dna content , mitotic index and cell number . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
39,
49
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
175,
183
]
} |
studies of agonist-specific desensitization of camp accumulation show that pge1 or pge2 can desensitize for subsequent pge or pgi2 activation , and that subthreshold levels of pgi2 desensitize for subsequent pge1 stimulation . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
83,
87
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
208,
211
]
} |
pgd2 desensitizes for consequent pgd2 activation , but not for pge1 , pge2 or pgi2 , and pge compounds and pgi2 do not desensitize for subsequent pgd2 activation . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
70,
74
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
89,
92
]
} |
the most common arrhythmias associated with the high doses of cantharidin were frequent ventricular ectopics , ventricular tachycardia , ventricular fibrillation or asytole . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
16,
27
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
137,
161
]
} |
n-nitroso compounds , consisting of nitrosamines and nitrosamides , are potentially important in the etiology of human cancer . | NA | {
"id": "C0028199",
"name": "nitroso compounds",
"pos": [
2,
19
]
} | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
36,
48
]
} |
in this analogue , the hydrogens of the primary carboxamide moiety in the side chain of the asparagine residue in position 5 of the posterior pituitary hormone oxytocin have been replaced by two methyl groups . | NA | {
"id": "C0032017",
"name": "posterior",
"pos": [
132,
141
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
160,
168
]
} |
the magnitude of the hco3 secretion remained unchanged , but shifted from a hco3-cl exchange to a net secretion of nahco3 and khco3 . | NA | {
"id": "C0005367",
"name": "hco3",
"pos": [
21,
25
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
115,
121
]
} |
the magnitude of the hco3 secretion remained unchanged , but shifted from a hco3-cl exchange to a net secretion of nahco3 and khco3 . | NA | {
"id": "C0005367",
"name": "hco3",
"pos": [
21,
25
]
} | {
"id": "C0071751",
"name": "khco3",
"pos": [
126,
131
]
} |
we have developed a photoplethysmographic technique for monitoring early signs of vascular compromise in extremities affected by direct vessel trauma , crushing trauma , or circumferential burns . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
143,
149
]
} | {
"id": "C0006434",
"name": "burns",
"pos": [
189,
194
]
} |
clinically , we have used this monitoring technique on 29 trauma patients thus far , including 18 with circumferential full-thickness burns of at least one extremity . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
58,
64
]
} | {
"id": "C0006434",
"name": "burns",
"pos": [
134,
139
]
} |
after rigorous antibody treatment , four of seven clones still released virus spontaneously upon removal of antiserum ; | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
15,
23
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
108,
117
]
} |
the number of rous viral genomes in the cellular dna from two subclones ( rs2/3 , rs2/6 ) derived from the same clone of hamster bhk-21 cells transformed by rous sarcoma virus was determined by hybridization with viral complementary dna made in vitro , and the capacity of the cellular dna to infect ( transfect ) chicke... | NA | {
"id": "C0012939",
"name": "viral",
"pos": [
19,
24
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
385,
388
]
} |
the number of rous viral genomes in the cellular dna from two subclones ( rs2/3 , rs2/6 ) derived from the same clone of hamster bhk-21 cells transformed by rous sarcoma virus was determined by hybridization with viral complementary dna made in vitro , and the capacity of the cellular dna to infect ( transfect ) chicke... | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
40,
48
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
329,
340
]
} |
it was shown that cells of both subclones contain a single copy of rous dna and yield infectious dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
4,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
97,
100
]
} |
failure to control the thyrotoxic state with antithyroid drugs in one patient prior to treatment with radioactive iodine led to exacerbation of the thyrotoxicosis with thyroid storm and death . | NA | {
"id": "C0040156",
"name": "thyrotoxicosis",
"pos": [
148,
162
]
} | {
"id": "C0040127",
"name": "thyroid storm",
"pos": [
168,
181
]
} |
the hemodynamic effects of daily treadmill exercise were evaluated in hamsters with experimental thiamine deficiency to test the hypothesis that increased energy consumption might be a contributory factor in the pathogenesis of beriberi heart disease . | NA | {
"id": "C0039841",
"name": "thiamine deficiency",
"pos": [
97,
116
]
} | {
"id": "C0005122",
"name": "beriberi",
"pos": [
228,
236
]
} |
thus , it was suggested that prostaglandins ( especially pge ) modulated the pulmonary vasoconstrictor effects of angiotensin ii . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
29,
43
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
57,
60
]
} |
[ nursing of a patient with difficulty in swallowing due to esophageal disease - nursing of an aged patient having undergone surgery of esophageal cancer ] . | NA | {
"id": "C0011168",
"name": "difficulty in swallowing",
"pos": [
28,
52
]
} | {
"id": "C0014852",
"name": "esophageal disease",
"pos": [
60,
78
]
} |
several investigations into the prophylactic use of lidocaine to prevent the development of arrhythmias have shown that lidocaine , given in therapeutic doses , is effective in preventing ventricular fibrillation and in reducing early mortality . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
92,
103
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
188,
212
]
} |
spontaneous hemothorax may represent a form of spontaneous hemopneumothorax or it may be a complication of a variety of situations . | NA | {
"id": "C0019123",
"name": "hemothorax",
"pos": [
12,
22
]
} | {
"id": "C0019077",
"name": "hemopneumothorax",
"pos": [
59,
75
]
} |
a feeder layer of mitomycin c-treated human fibroblasts increased the plating efficiency of both normal and malignant cells in primary culture and also facilitated passage of these cells to secondary and tertiary cultures . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
44,
55
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
181,
186
]
} |
electrophoretic resolution of these protein fractions allowed the direct comparison of dna-binding proteins from pools of serum from cancer patients , fetuses , or normal humans . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
36,
43
]
} | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
87,
107
]
} |
a 26-year-old woman was discovered to have a left atrial myxoma during the second trimester of pregnancy . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
75,
91
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
95,
104
]
} |
leukemic cell lines reveal a new approach for the search after leukemia-associated proteins and represent another possibility for the experimental investigation of the etiology of leukemia . | NA | {
"id": "C0023418",
"name": "associated",
"pos": [
72,
82
]
} | {
"id": "C0023441",
"name": "experimental",
"pos": [
134,
146
]
} |
one week after birth the low molecular weight proteins predominated because there was a substantial decrease in the excretion of albumin and of high molecular weight proteins ( mw greater than or equal to 150 000 dt ) . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
129,
136
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
166,
174
]
} |
additional possible indices of adrenergic dysfunction such as the pressor response to cold stimulus , plasma renin levels and noradrenaline or adrenaline excretion rates did not differ significantly between normal subjects and diabetics . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
126,
139
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
143,
153
]
} |
proximal tubular cells of albumin-exchanged animals contained fewer protein absorption droplets and no intraluminal material . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
26,
33
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
68,
75
]
} |
the presence of immune receptors ( igg-fc and complement receptors ) was examined in normal human tissues from various organs . | NA | {
"id": "C0034817",
"name": "immune receptors",
"pos": [
16,
32
]
} | {
"id": "C0034793",
"name": "complement receptors",
"pos": [
46,
66
]
} |
nuclei isolated by grinding 9l rat brain tumors gave a dna distribution consisting of a 2c dna peak due to noncycling normal cells and a bimodal distribution beginning at about 4c dna due to the cycling tumor cells . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
55,
58
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
182,
183
]
} |
estrogen receptors ( er ) were measured on biopsy specimens of melanoma ( two patients ) , soft-tissue sarcoma ( four patients ) , cystosarcoma phylloides ( five patients ) , benign breast tissues ( 27 patients ) , and breast carcinoma ( 109 patients ) . | NA | {
"id": "C1261473",
"name": "soft-tissue sarcoma",
"pos": [
91,
110
]
} | {
"id": "C0010701",
"name": "cystosarcoma phylloides",
"pos": [
131,
154
]
} |
one of the five cystosarcoma phylloides and five of the six nonmammary sarcoma tissues contained er ( mainly of the 4 svedburg ( s ) variety ) of more than 7 femtomoles ( fmoles ) /mg cytosol proteins ( 6/11 = 54 % ) . | NA | {
"id": "C0010701",
"name": "cystosarcoma phylloides",
"pos": [
16,
39
]
} | {
"id": "C1261473",
"name": "sarcoma",
"pos": [
71,
78
]
} |
six of the 10 aneurysms were false ( pseudoaneurysms ) , and four were classified as true aneurysms . | NA | {
"id": "C1510412",
"name": "pseudoaneurysms",
"pos": [
37,
52
]
} | {
"id": "C0002940",
"name": "aneurysms",
"pos": [
90,
99
]
} |
three of four patients with true inferior aneurysms had mitral valve dysfunction , whereas only two of six patients with false aneurysms required mitral valve replacement ( one because of infective endocarditis ) . | NA | {
"id": "C0002940",
"name": "aneurysms",
"pos": [
42,
51
]
} | {
"id": "C1510412",
"name": "false aneurysms",
"pos": [
121,
136
]
} |
therefore , it may be said that there are rhythmic lymph flows in lower leg of subjects without edema and of patients with cardiac edema not only in supine but also in sitting position , and also that lymphatic contractility plays some role in propelling lymph in human leg . | NA | {
"id": "C0013604",
"name": "edema",
"pos": [
96,
101
]
} | {
"id": "C0013608",
"name": "cardiac edema",
"pos": [
123,
136
]
} |
they also seem to indicate a distinct advantage of marrow cells over peripheral-blood mononuclear cells in their ability to correct marrow aplasia . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
58,
63
]
} | {
"id": "C1321301",
"name": "peripheral-blood mononuclear cells",
"pos": [
69,
103
]
} |
these findings do not provide evidence for the involvement of hepatitis-a virus in the outbreak of hepatitis and effectively exclude a role for this virus in the chrnoic liver disease which developed subsequently in 8 ( 28 % ) of the patients . | NA | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
62,
71
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
170,
183
]
} |
in children aged 15 -- 16 years receiving routine reinforcement tetanus immunisation , adsorbed vaccine caused more severe and more frequent local reactions than did plain formol toxoid , and a higher incidence of pyrexia . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
96,
103
]
} | {
"id": "C0040555",
"name": "toxoid",
"pos": [
179,
185
]
} |
we have seen that in the case of positive rast reactions to household dust , which is a mixed antigen unspecific as such , evidence can be found for at least one of the antigens `` '' mould fungus '' '' , `` '' household dust mite '' '' , or `` '' animal hair '' '' in positive rast categories . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
94,
101
]
} | {
"id": "C0003330",
"name": "antigens",
"pos": [
169,
177
]
} |
so-called tantalum-visors are used to refixate the multifractured facial skeleton , torn off the base of the skull by trauma , in a three dimensional way to avoid dishface and pseudotelorismus . | NA | {
"id": "C0043246",
"name": "torn",
"pos": [
84,
88
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
118,
124
]
} |
the co2 laser has been found to be an indispensable tool in the transoral management of t1 carcinomas , multiple superficial carcinoma , extensive leukoplakia and verrucous carcinoma . | NA | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
91,
100
]
} | {
"id": "C0206706",
"name": "verrucous carcinoma",
"pos": [
163,
182
]
} |
therefore endoscopic retrograde cholangiopancreaticography ( ercp ) was performed , allowing to establish congenital biliary tract anomalies , cholelithiasis and benign obstruction of the extrahepatic biliary tract as causes of the cholestatic syndromes . | NA | {
"id": "C0005398",
"name": "obstruction",
"pos": [
169,
180
]
} | {
"id": "C0008370",
"name": "cholestatic",
"pos": [
232,
243
]
} |
superoxide and hydrogen peroxide production and nadph oxidation stimulated by nitrofurantoin in lung microsomes : possible implications for toxicity . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
0,
10
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
24,
32
]
} |
benzophenanthridine alkaloids , fagaronine 4 , o-methylfagaronine 5 , nitidine 1 , allonitidine 3 and methoxydihydronitidine 2 have been shown to possess inhibitory activity against reverse transcriptase of rna tumor viruses . | NA | {
"id": "C1720921",
"name": "benzophenanthridine",
"pos": [
0,
19
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
20,
29
]
} |
the results suggested that the benzophenanthridine alkaloids interacted with the template primers ( particularly of the a : t base pairs ) and not with the enzyme proteins . | NA | {
"id": "C1720921",
"name": "benzophenanthridine",
"pos": [
31,
50
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
51,
60
]
} |
but , while prohibiting gallstone growth , it did not affect stone dissolution over 24 months ' treatment . | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
24,
33
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
61,
66
]
} |
free sterols and sterols esters were also isolated in a liquid fraction obtained by low temperature crystallization ( -80 c ) of the oils and enriched with minor lipid classes . | NA | {
"id": "C0028908",
"name": "oils",
"pos": [
133,
137
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
162,
167
]
} |
a simple procedure for determination of levels of free choline and phosphorylcholine in hepatic tissue is outlined . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
55,
62
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
67,
84
]
} |
the method makes use of the enzyme acid phosphatase to liberate choline from phosphorylcholine and incorporates the ability of choline to react with potassium triiodide to yield choline periodide for the measurement of choline and phosphorylcholine in liver . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
64,
71
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
231,
248
]
} |
the method is accurate for both entities ( recovery of 97-100 % for choline and 92-98 % for phosphorylcholine ) . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
68,
75
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
92,
109
]
} |
the applicability of the method was shown when it was demonstrated that diets containing different amounts of choline influenced the level of choline and phosphorylcholine in liver . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
110,
117
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
154,
171
]
} |
the clinical presentations in 12 patients varied markedly , as did their urinary excretion rates of norepinephrine , epinephrine and their metabolites . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
100,
114
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
117,
128
]
} |
most cases are associated with a paraprotein , cryoglobulin , or autoantibody , which presumably initiates c1 activation and c1 inhibitor consumption . | NA | {
"id": "C0030490",
"name": "paraprotein",
"pos": [
33,
44
]
} | {
"id": "C0010404",
"name": "cryoglobulin",
"pos": [
47,
59
]
} |
with hypoglycemia , the lowering of plasma triglyceride concentration correlated significantly with the stimulation of urinary epinephrine output ( r = 0.86 ) but with neither the urinary norepinephrine response nor with the increase in plasma immunoreactive glucagon levels . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
127,
138
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
188,
202
]
} |
it is suggested that the observed increase in fatty acids in the heart following thyroxine or isoprenaline treatment is related to the increase in serum free fatty acids , which is followed by an increase in the removal of serum fatty acids by the heart . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
153,
169
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
229,
240
]
} |
the male/female diabetic ratio was affected by weight status -- in the underweight , diabetes was more prevalent in males , in the overweight , the rate of diabetes in females equaled that of males . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
47,
53
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
131,
141
]
} |
in nontoxic dose ranges , the induction of mutants and recombinants was parallel after treatment with ethyl methanesulfonate ( ems ) , methyl methanesulfonate ( mms ) , n-methyl-n'-nitro-m-nitrosoguanidine ( mnng ) , triethylene melamine ( tem ) , 4-nitroquinoline 1-oxide ( 4-nqo ) , sodium nitrite ( nano2 ) , and 1-fl... | NA | {
"id": "C0012459",
"name": "dinitrobenzene",
"pos": [
329,
343
]
} | {
"id": "C0012463",
"name": "dnfb",
"pos": [
350,
354
]
} |
( ii ) electron micrographs of prsd1-dna isolated from tetracycline-stressed cells reveal a heterogeneous population of circular dna molecules ranging between 1.7 and 21.6 micron . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
37,
40
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
120,
132
]
} |
analysis of particles with dna fragments derived from different regions of the salmonella chromosome indicated that the replication of the bacterial dna carried by these transducing particles was not initiated specifically at the normal origin for bacterial chromosome replication . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
27,
30
]
} | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
139,
152
]
} |
analysis of a subgroup of 126 children showed that birthweight , weight at one year of age , and current nutrition did not affect the level of the fvc . | NA | {
"id": "C0005612",
"name": "birthweight",
"pos": [
51,
62
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
65,
71
]
} |
for the treatment of pseudomonas aeruginosa infections of all penicillins azlocillin is the most favourable drug ( instead of carbenicillin ) , for treatment of esch . coli infections it is mezlocillin ( instead of ampicillin ) . | NA | {
"id": "C0004499",
"name": "azlocillin",
"pos": [
74,
84
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
215,
225
]
} |
for the treatment of pseudomonas aeruginosa infections of all penicillins azlocillin is the most favourable drug ( instead of carbenicillin ) , for treatment of esch . coli infections it is mezlocillin ( instead of ampicillin ) . | NA | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
190,
201
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
215,
225
]
} |
becampicillin and equally amoxycillin are more than ampicillin suitable for oral application ( because of almost complete absorption ) . | NA | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
26,
37
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
52,
62
]
} |
cefaclor has a broader spectrum and stronger activity than cefalexin and will replace cefalexin in future . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
0,
8
]
} | {
"id": "C0007716",
"name": "cefalexin",
"pos": [
86,
95
]
} |
both type a and b isoenzymes were found in normal tissues , but the myeloblasts showed only one enzyme type , indicating that at the time of study , the disease had a clonal origin . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
18,
28
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
96,
102
]
} |
we found immune interferon in the serums of patients with systemic lupus erythematosus , rheumatoid arthritis , scleroderma and sjogren 's syndrome . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
89,
109
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
128,
147
]
} |
microneurosurgical procedures on the trigeminal-nerve root are often followed by reactivation of herpes simplex virus infection , manifested by herpes labialis or oropharyngeal herpesvirus shedding or both . | NA | {
"id": "C0019348",
"name": "herpes simplex virus infection",
"pos": [
97,
127
]
} | {
"id": "C0019345",
"name": "herpes labialis",
"pos": [
144,
159
]
} |
phosphatidyl choline was the major phospholipid fraction and along with phosphatidyl ethanolamine accounted for 60 -- 65 % of the total phospholipid . | NA | {
"id": "C0771648",
"name": "phospholipid fraction",
"pos": [
35,
56
]
} | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
136,
148
]
} |
by using specific cell lines to such a mycotoxin and specific inactivators as coumarin for aflatoxin , or sulfhydryl compounds for penicillic acid and patulin . | NA | {
"id": "C0026955",
"name": "mycotoxin",
"pos": [
39,
48
]
} | {
"id": "C0030710",
"name": "patulin",
"pos": [
151,
158
]
} |
role of the dendritic release of dopamine in the reciprocal control of the two nigro-striatal dopaminergic pathways . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
33,
41
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
94,
106
]
} |
[ biguanides , rejection of treatment with buformin and fenformin , and restriction of indications for the use of metformin ] . | NA | {
"id": "C0005382",
"name": "biguanides",
"pos": [
2,
12
]
} | {
"id": "C0006359",
"name": "buformin",
"pos": [
43,
51
]
} |
[ biguanides , rejection of treatment with buformin and fenformin , and restriction of indications for the use of metformin ] . | NA | {
"id": "C0005382",
"name": "biguanides",
"pos": [
2,
12
]
} | {
"id": "C0031404",
"name": "fenformin",
"pos": [
56,
65
]
} |
[ biguanides , rejection of treatment with buformin and fenformin , and restriction of indications for the use of metformin ] . | NA | {
"id": "C0005382",
"name": "biguanides",
"pos": [
2,
12
]
} | {
"id": "C0025598",
"name": "metformin",
"pos": [
114,
123
]
} |
the lysis of cross-linked fibrin in intraglomerular deposits , as evidenced by the presence of dimeric fragment d in the urine , appeared to contribute only a small amount to the total urinary fdp excretion . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
26,
32
]
} | {
"id": "C0163275",
"name": "fdp",
"pos": [
193,
196
]
} |
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