text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
both types of glial cells were shown to develop biochemical tolerance to pentobarbital as defined by an attenuated response to the depressant effects of a challenging dose of pentobarbital on cellular respiration in barbiturate-cultivated cells compared to those grown in drug-free medium . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
73,
86
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
216,
227
]
} |
a cohort of 666 children who had convulsions with fever were followed to determine the risks of subsequent epilepsy . | NA | {
"id": "C0009952",
"name": "convulsions",
"pos": [
33,
44
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
107,
115
]
} |
the risk of developing epilepsy by age 20 was about 6 percent for all children who had experienced febrile convulsions . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
23,
31
]
} | {
"id": "C0009952",
"name": "febrile convulsions",
"pos": [
99,
118
]
} |
of the 16 perinatal deaths 6 died antepartum , 2 died in labor , and 8 died as neonates . | NA | {
"id": "C0701826",
"name": "perinatal deaths",
"pos": [
10,
26
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
71,
75
]
} |
in only 2 instances was a reactive nst followed by a death from apparent asphyxia . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
53,
58
]
} | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
73,
81
]
} |
as a result largely of therapeutic trials with various metabolites of vitamin d , we now know something of their probable involvement in the development of rickets and osteomalacia . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
156,
163
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
168,
180
]
} |
[ principles of treatment of nerve injuries of the hand and fingers at late periods after trauma ] . | NA | {
"id": "C0018571",
"name": "of",
"pos": [
13,
15
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
90,
96
]
} |
pneumomediastinum , pneumothorax , cervical emphysema and ectopic location of a feeding catheter , alone or in combination , were identified in the chest roentgenograms of 16 patients . | NA | {
"id": "C0025062",
"name": "pneumomediastinum",
"pos": [
0,
17
]
} | {
"id": "C0013990",
"name": "emphysema",
"pos": [
44,
53
]
} |
a total population study of drowning and near-drowning accidents involving honolulu infants has enabled the risks to be specified with greater detail . | NA | {
"id": "C0013142",
"name": "drowning",
"pos": [
28,
36
]
} | {
"id": "C0027516",
"name": "near-drowning",
"pos": [
41,
54
]
} |
the cdna product is 95 % sensitive to sl-nuclease and hybridisation analysis against viral rna reveals it to be a faithful copy of the rna . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
85,
94
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
135,
138
]
} |
dnase i digestion of nu 1 ( da-dt ) produces a ladder of dna fragments fiffering in lengthy by one base residue . nu 1 ( da-dt ) contain 146 base pairs of dna and exhibit an average dna helix pitch of 10.4-10.5 bases per turn . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
2,
3
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
182,
185
]
} |
second , the synthesis of nucleic acids is catalyzed by a complex enzyme system which contains at least two separate enzymes , one responsible for nucleic acid polymerization and the other for energy conservation via pyrophosphate condensation . | NA | {
"id": "C0026741",
"name": "complex enzyme",
"pos": [
58,
72
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
117,
124
]
} |
we conclude that this segregation , as determined by tightly-bound nonhistone chromosomal proteins , selects a subset of total genomic dna sequences , and suggests sequence-specific interaction between the tightly-bound nonhistones and dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
14,
15
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
236,
239
]
} |
it is shown by hybridization with a purified dna component complementary to total nuclear rna that nuclear poly a+rna in both cell types has only one fifth of total nuclear rna complexity ( as has polysomal rna ) , but still contains all poly a+rna present in polysomal poly a+rna . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
82,
93
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
277,
280
]
} |
firstly , the identity of the ribonuclease t1 octanucleotide attached to s7 is confirmed by a new method , which involves isolation and analysis of s7-polynucleotide complexes containing 30 -- 40 nucleotides . | NA | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
151,
165
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
196,
207
]
} |
the sequences confirm the two main homologies found between other known promoters for e. coli rna polymerase ( nucleoside triphosphate : rna nucleotidyl transferase , e.c . | NA | {
"id": "C0035681",
"name": "rna polymerase",
"pos": [
94,
108
]
} | {
"id": "C0035673",
"name": "rna nucleotidyl transferase",
"pos": [
137,
164
]
} |
the chest roentgenogram also apprises of the development , and consequently of the need for treatment , of such complications as interstital emphysema , pneumothorax , pneumomediastinum , pneumoperitoneum and subcutaneous emphysema . | NA | {
"id": "C0013990",
"name": "emphysema",
"pos": [
141,
150
]
} | {
"id": "C0025062",
"name": "pneumomediastinum",
"pos": [
168,
185
]
} |
the chest roentgenogram also apprises of the development , and consequently of the need for treatment , of such complications as interstital emphysema , pneumothorax , pneumomediastinum , pneumoperitoneum and subcutaneous emphysema . | NA | {
"id": "C0013990",
"name": "emphysema",
"pos": [
141,
150
]
} | {
"id": "C0038536",
"name": "subcutaneous emphysema",
"pos": [
209,
231
]
} |
the relationship between the effects of isoproterenol and prostaglandin e ( 1 ) ( pge ( 1 ) ) on contractile state , cyclic amp accumulation , and the activation states of protein kinase ( atp : protein phosphotransferase , ec 2.7.1.37 ) , phosphorylase kinase , glycogen synthase , and glycogen phosphorylase have been ... | NA | {
"id": "C0033640",
"name": "protein phosphotransferase",
"pos": [
195,
221
]
} | {
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
240,
260
]
} |
in contrast , replacement of cytosine with 5-bromocytosine , which forms stronger pairs with guanine , enhanced termination at this site . rho-independent termination was not altered by replacing uracil with 5-bromouracil . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
196,
202
]
} | {
"id": "C0006242",
"name": "5-bromouracil",
"pos": [
208,
221
]
} |
the incorporation of 5-bromouracil instead of uracil into rna did not alter the site specificity of rho action but rho was rendered inactive when cytosine was replaced by 5-bromocytosine . | NA | {
"id": "C0006242",
"name": "bromouracil",
"pos": [
23,
34
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
46,
52
]
} |
replication in vitro of the replicative form ( rf ) i dna of bacteriophage varphix174 requires the phage-induced cistron a ( cisa ) protein , the host rep protein , dna-binding protein , atp , and dna polymerase iii plus replication factors . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
132,
139
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
165,
184
]
} |
furthermore , the large ppgpp stimulation of lacp ( + ) dna enabled the level of expression of this template to approach that of lacp ( r ) l8uv5 dna , an observation expected from results in vivo but not obtained with other transcription-translation systems in vitro . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
56,
59
]
} | {
"id": "C0012933",
"name": "r",
"pos": [
265,
266
]
} |
procollagen and fibronectin are major products of confluent fibroblasts in culture and both are released from the cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
60,
71
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
114,
119
]
} |
two independent experimental approaches were used : ( i ) non-virus-producing fibroblasts prepared from homozygous balb/mo embryos were fused to chinese hamster wg3-h-o cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
78,
89
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
169,
174
]
} |
myeloma-spleen cell hybrids ( hybridomas ) producing antibody to mouse immunoglobulin allotypes have been labeled with fluorescent microspheres coupled with myeloma protein antigens . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
53,
61
]
} | {
"id": "C0021006",
"name": "immunoglobulin allotypes",
"pos": [
71,
95
]
} |
the results support the concept that muscle cell damage in graves ophthalmopathy is immunological , cell-mediated , and of two types : ( i ) k lymphocytes reacting to immune complex , tga , on the eye muscle cell surface ( i.e. , antibody-dependent cytotoxicity ) and ( ii ) sensitized t lymphocytes reacting to tg on th... | NA | {
"id": "C0003313",
"name": "immune complex",
"pos": [
167,
181
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
230,
238
]
} |
at physiological concentration ( 50 microgram/ml ) , alpha 2pi inhibited the clot-promoting and prekallikrein-activating activity of hageman factor fragments , the amidolytic , kininogenase , and clot-promoting activities of plasma kallikrein , and the clot-promoting properties of activated plasma thromboplastin antece... | NA | {
"id": "C0015522",
"name": "plasma thromboplastin antecedent",
"pos": [
292,
324
]
} | {
"id": "C0015524",
"name": "factor xia",
"pos": [
333,
343
]
} |
studies on the immunoprecipitation of the proteins of several different measles and subacute sclerosing panencephalitis ( sspe ) virus strains from lysates of infected cells have revealed a relative lack of antibodies to the nonglycosylated viral membrane protein ( m ) in the sera of patients with sspe , in contrast to... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
42,
50
]
} | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
357,
371
]
} |
the charge/site ratios are 6.0 with ferrocyanide and with succinate + tmpd ( at ph < 7.0 ) and 4.0 with ascorbate + tmpd ; | NA | {
"id": "C0031468",
"name": "tmpd",
"pos": [
70,
74
]
} | {
"id": "C0048678",
"name": "4",
"pos": [
95,
96
]
} |
hybrid cells containing the human alpha globin structural genes were derived by fusion of populations of adult human peripheral blood mononuclear cells ( devoid of identifiable erythroid cells ) with adenine phosphoribosyl-transferase-deficient mouse erythroleukemia cells that contained close to a tetraploid complement... | NA | {
"id": "C1321301",
"name": "peripheral",
"pos": [
117,
127
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
267,
272
]
} |
the inhibition of binding is competitive with respect to oligo ( dt ) - or oligo ( da ) -celluloses , suggesting that the effect of the dye is directly on the polynucleotide binding site of the receptor . | NA | {
"id": "C0028953",
"name": "oligo",
"pos": [
57,
62
]
} | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
159,
173
]
} |
by competition studies , antibody [ ( 3 ) h ] dihydroalprenolol binding was found to display a specificity and stereoselectivity resembling that of the beta-adrenergic receptor , [ i.e. , ( - ) -isoproterenol > ( - ) -epinephrine > ( - ) -norepinephrine ; alprenolol approximately propranolol > > phentolamine = aloperid... | NA | {
"id": "C0012278",
"name": "dihydroalprenolol",
"pos": [
46,
63
]
} | {
"id": "C0002334",
"name": "alprenolol",
"pos": [
256,
266
]
} |
by competition studies , antibody [ ( 3 ) h ] dihydroalprenolol binding was found to display a specificity and stereoselectivity resembling that of the beta-adrenergic receptor , [ i.e. , ( - ) -isoproterenol > ( - ) -epinephrine > ( - ) -norepinephrine ; alprenolol approximately propranolol > > phentolamine = aloperid... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
218,
229
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
239,
253
]
} |
the implications of these findings for biosynthesis of membrane proteins in general and multimeric membrane proteins in particular , as well as the role of beta 2-microglobulin in expression of hla-a and hla-b antigens , are discussed . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
64,
72
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
99,
107
]
} |
the defect in responsiveness to endotoxin lipopolysaccharide ( lps ) by macrophages from c3h/hej mice extends equally to the synthesis of cs-factor and pge . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
32,
41
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
42,
60
]
} |
furthermore , they all contain a subset of peptides that are accounted for by the peptides from two known spectrin-binding fragments . | NA | {
"id": "C0030956",
"name": "peptides",
"pos": [
43,
51
]
} | {
"id": "C0030935",
"name": "peptides",
"pos": [
82,
90
]
} |
polyadenylylated rna [ poly ( a ) -rna ] , which is enriched in messenger and messenger-precursor rna sequences , was isolated from the above fibroblast lines . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
17,
20
]
} | {
"id": "C0035696",
"name": "messenger",
"pos": [
78,
87
]
} |
these tests included chemically induced sarcomas , leukemias , spontaneously transformed fibroblasts , and cells transformed by simian virus 40 and murine sarcoma virus . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
89,
100
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
107,
112
]
} |
aspartate aminotransferase , l-aspartate:2-oxoglutarate aminotransferase , ec 2.6.1.1 ) were determined for 201 patients on chronic renal dialysis . | NA | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
0,
26
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
56,
72
]
} |
leghaemoglobin is a product of the symbiotic interaction , since the globin is produced by the plant while the haem is synthesized by the bacteria . | NA | {
"id": "C0023235",
"name": "leghaemoglobin",
"pos": [
0,
14
]
} | {
"id": "C0017645",
"name": "globin",
"pos": [
69,
75
]
} |
furthermore , urinary excretions of epinephrine and norepinephrine increased in the flushing cases after the drinking . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
36,
47
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
52,
66
]
} |
behavioral effects and blood or plasma levels of d-amphetamine , ethanol , cocaine , and diazepam were examined in rhesus monkeys treated chronically with alpha-l-acetylmethadol ( laam ) , methadone , or vehicle . | NA | {
"id": "C0025607",
"name": "acetylmethadol",
"pos": [
163,
177
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
189,
198
]
} |
behavioral depression after diazepam was prolonged substantially in laam- and methadone-maintained monkeys , but blood levels of diazepam and metabolites were not increased prolonged in those animals . | NA | {
"id": "C0025607",
"name": "laam",
"pos": [
68,
72
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
78,
87
]
} |
naloxone partially antagonized the residual depression laam- and methadone-maintained monkeys 24 hr after diazepam , but had no effect on the weaker sesidual depression in vehicle-maintained aniamals . | NA | {
"id": "C0025607",
"name": "laam",
"pos": [
55,
59
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
65,
74
]
} |
the protein binding of colchicine and its derivatives demecolcine and desacetylcolchiceine was studied by equilibrium dialysis at 22 degrees c and ph 7.38 in bovine and human serum albumin and human plasma . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
23,
33
]
} | {
"id": "C0011259",
"name": "demecolcine",
"pos": [
54,
65
]
} |
colchicine and demecolcine ( 2 x 10 ( -4 ) -5 x 10 ( -4 ) mol/l ) is not bound to proteins . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
0,
10
]
} | {
"id": "C0011259",
"name": "demecolcine",
"pos": [
15,
26
]
} |
the binding profiles for desacetylcholchiceine were quite similar in human serum albumin ( 4 % conc . ) and human plasma ( 3.8 % conc . of albumin fraction ) . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
69,
88
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
139,
146
]
} |
the relative toxicity of the cannabinoids in these studies was delta9-thc greater than cbn greater than cbd . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
29,
41
]
} | {
"id": "C0039663",
"name": "delta9-thc",
"pos": [
63,
73
]
} |
the relative toxicity of the cannabinoids in these studies was delta9-thc greater than cbn greater than cbd . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
29,
41
]
} | {
"id": "C0006865",
"name": "cbn",
"pos": [
87,
90
]
} |
in our unoperated patients with orbital hypertelorism or craniofacial dysostosis , preoperative evaluation of the olfactory and gustatory functions showed normal values . | NA | {
"id": "C0020534",
"name": "orbital hypertelorism",
"pos": [
32,
53
]
} | {
"id": "C0010273",
"name": "craniofacial dysostosis",
"pos": [
57,
80
]
} |
toward an optimal dtpa therapy for decorporation of actinides : time-dose relationships for plutonium in the dog . | NA | {
"id": "C0025553",
"name": "actinides",
"pos": [
52,
61
]
} | {
"id": "C0032259",
"name": "plutonium",
"pos": [
92,
101
]
} |
in cases of trauma , ct was able to identify , localize , and characterize fracture fragments and bone or joint displacement . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
12,
18
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
75,
83
]
} |
the vlue of epinephrine enhanced angiography in the preoperative distinction of isolated hamartoma ( angiomyolipoma without stigma of tuberous sclerosis ) from hypernephroma has been largely discounted in the past . | NA | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
89,
98
]
} | {
"id": "C0041341",
"name": "tuberous sclerosis",
"pos": [
134,
152
]
} |
comparison of response of experimental tumors to adjuvant chemotherapy for minimal disease with the response of solid large tumors to similar drug regimens has indicated that for many tumors the small microscopic foci are more responsive . | NA | {
"id": "C0027659",
"name": "experimental tumors",
"pos": [
26,
45
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
184,
190
]
} |
the time course for changes in hepatic oxidized glutathione ( gssg ) after acetaminophen administration followed that for gsh in both control and diabetic rats . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
62,
66
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
122,
125
]
} |
as a group , these patients in whom embolism was judged probable approached fairly closely the profiles of previous studies of patients with documented pulmonary emboli . | NA | {
"id": "C0013922",
"name": "embolism",
"pos": [
36,
44
]
} | {
"id": "C0034065",
"name": "pulmonary emboli",
"pos": [
152,
168
]
} |
nor could generation of traces of factor xia in such mixtures be detected by incubation with purified factor ix and testing for the generation of activated factor ix ( ixa ) in clotting and amidolytic assays . | NA | {
"id": "C0015491",
"name": "factor ix",
"pos": [
102,
111
]
} | {
"id": "C0015494",
"name": "activated",
"pos": [
146,
155
]
} |
moreover , when blood or platelet-rich plasma containing added 125i-factor ix was incubated with calcium ions and collagen and then subjected to reduced sodium dodecyl sulfate polyacrylamide gel electrophoresis , the radioactivity profiles revealed only native 125i-factor ix without evidence of the polypeptide chains o... | NA | {
"id": "C0015491",
"name": "factor ix",
"pos": [
68,
77
]
} | {
"id": "C0015494",
"name": "factor ixa",
"pos": [
322,
332
]
} |
investigation revealed not only impaired synthesis of coagulation factors but also abnormal proteolysis by plasmin as well as by other proteolytic enzymes liberated from leucocytes and damaged tissue cells affecting especially factor viii and factor xiii . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
54,
73
]
} | {
"id": "C0015506",
"name": "factor",
"pos": [
243,
249
]
} |
investigation revealed not only impaired synthesis of coagulation factors but also abnormal proteolysis by plasmin as well as by other proteolytic enzymes liberated from leucocytes and damaged tissue cells affecting especially factor viii and factor xiii . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
54,
73
]
} | {
"id": "C0015528",
"name": "factor xiii",
"pos": [
243,
254
]
} |
on may 1 , 1976 , a randomized , controlled clinical trial commenced : patients admitted for fresh burns were divided into groups : one group was unsuited for trail ( u ) , ( e.g . small children , electric burns etc . ) ; | NA | {
"id": "C0006434",
"name": "burns",
"pos": [
99,
104
]
} | {
"id": "C0006436",
"name": "electric",
"pos": [
198,
206
]
} |
chemical agents were mainly responsible for this type of burn , whereas electrical burns were chiefly full thickness skin injuries . | NA | {
"id": "C0006434",
"name": "burn",
"pos": [
57,
61
]
} | {
"id": "C0006436",
"name": "electrical burns",
"pos": [
72,
88
]
} |
in the case of the severely burned patient who has already sustained gross trauma , any further destruction of tissues is to be avoided at all costs . | NA | {
"id": "C0006434",
"name": "burned",
"pos": [
28,
34
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
75,
81
]
} |
d-penicillamine treatment in rheumatoid arthritis monitored by plasma alfa-1-antitrypsin-iga complexes and plasma and urinary sulphur containing aminoacids . | NA | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
2,
15
]
} | {
"id": "C0002527",
"name": "sulphur",
"pos": [
126,
133
]
} |
[ protection from exertion-induced bronchial asthma with disodium cromoglycate ( dscg ) ( cromolyn , lomudal , intal ) and with ketotifen ( zaditen ) . doubly crossed double-blind study ] . | NA | {
"id": "C0012694",
"name": "disodium cromoglycate",
"pos": [
57,
78
]
} | {
"id": "C0086073",
"name": "cromolyn",
"pos": [
90,
98
]
} |
16 cooperative asthmatic patients with exercise-induced asthma ( with more than 15 % decrease in fev1 after strenuous work on a treadmill with 10 % upward ; pulse rates over 180 per minute during the work-phase ) were selected to take part in a double-blind crossover trial . | NA | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
15,
24
]
} | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
39,
62
]
} |
we have examined the in vivo conversion of 3h- ( 25,26 ) -25-hydroxyvitamin d3 ( 25ohd3 ) to 3h- ( 25,26 ) -1 alpha,25-dihydroxyvitamin d3 [ 1 alpha,25 ( oh ) 2d3 ] in vitamin d-deficient , pregnant and nonpregnant rats . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
58,
78
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
81,
87
]
} |
kindling is an experimental model of epilepsy in which periodic brain stimulation induces the progressive development of electrical and behavioral seizures . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
37,
45
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
147,
155
]
} |
the data reported predict the previously unknown sequence of the signal peptide of human growth hormone and , by comparison with the previously determined sequences of rat growth hormone and human chorionic somatomammotropin , strengthens the hypothesis that these genes evolved by gene duplication from a common ancestr... | NA | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
83,
103
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
172,
186
]
} |
the underlying cause of this clinical syndrome was established by computerized axial tomography as vascular infarction or ischemia , involving the contralateral visual cortex . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
108,
118
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
122,
130
]
} |
adjuvant effects of hemoglobin , methemoglobin , hematin , and ferric nitrilotriacetate ( fenta ) on the lethality of e. coli peritonitis in rats were compared . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
20,
30
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
33,
46
]
} |
the effects of hemoglobin and methemoglobin were virtually identical , suggesting that the oxidation state of the metallic center is immaterial , and analyses of peritoneal contents during lethal peritonitis promoted by either adjuvant revealed insignificant interconversions of these compounds . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
15,
25
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
30,
43
]
} |
[ glycoproteins , mucoproteins and collagen metabolites in the assessment of lung inflammation and sclerosis in chronic pneumonia ] . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
2,
15
]
} | {
"id": "C0026714",
"name": "mucoproteins",
"pos": [
18,
30
]
} |
in cells sending out cytoplasmic projections during migration and development , for example , axons in embryonic , newly hatched or pupal tissues , tracheoles or fibroblasts , the intramembranous ridges are always aligned parallel to the longitudinal axis of the cellular process . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
162,
173
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
263,
271
]
} |
the metabolites identified were as follows : the parent drug , monohydroxy tsaa-291 having the additional hydroxy function in the steroid skeleton , 17 beta-hydroxy-16 beta- ( 1 xi-hydroxyethyl ) -4-estren-3-one , 16 beta-ethyl-17 beta-hydroxy-5 beta-estran-3-one , 16 beta-ethyl-17 beta-hydroxy-5 alpha-estran-3-one , 1... | NA | {
"id": "C0038317",
"name": "steroid",
"pos": [
130,
137
]
} | {
"id": "C0014924",
"name": "estrane",
"pos": [
395,
402
]
} |
the usefulness of cetylpyridium chloride and cetylpyridium bromide , at a final concentration of 1 % in 1 % solution of sodium chloride , for the transportation of sputum in tuberculosis bacteriology , was evaluated . | NA | {
"id": "C0007907",
"name": "cetylpyridium chloride",
"pos": [
18,
40
]
} | {
"id": "C0007906",
"name": "cetylpyridium",
"pos": [
45,
58
]
} |
under these conditions permeability of erythrocytes and leucocytes membranes as well as of the liver and brain mitochondria increases for [ 14c ] nicotinate , [ 35s ] lipoate , riboflavin and flavin mononucleotide , the total activity and the activity of the unprecipitable protinase of the liver cell lysosomas rise . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
177,
187
]
} | {
"id": "C0016388",
"name": "flavin",
"pos": [
192,
198
]
} |
considering technical and economical factors it seems to be proven that silicon elastomer and polyurethane are the most appropriate materials for splints and catheters , whereas rubber and pvc are less suitable for long time application . | NA | {
"id": "C0013766",
"name": "elastomer",
"pos": [
80,
89
]
} | {
"id": "C0032616",
"name": "polyurethane",
"pos": [
94,
106
]
} |
not infrequently lactational mastitis occurred as a result of a pathological delivery and hospitalism , in 8 % of patients lactational mastitis being nothing but a local manifestation of a general purulent infection -- sepsis . | NA | {
"id": "C0243026",
"name": "general",
"pos": [
189,
196
]
} | {
"id": "C0036690",
"name": "sepsis",
"pos": [
219,
225
]
} |
on the grounds of morphologic studies the authors suppose that pulmonary complications of a severe mechanical trauma without injuries to thoracic organs are due to microcirculatory disorders and to microatelectases resulting from the trauma . | NA | {
"id": "C0039980",
"name": "injuries",
"pos": [
125,
133
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
234,
240
]
} |
a-protein and ligandin are the isoforms of binding proteins , which characterize different steps of the differentiation of the hepatocytes . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
2,
9
]
} | {
"id": "C0597298",
"name": "isoforms",
"pos": [
31,
39
]
} |
the alteration referred primarily to neutral lipids , especially to triacyl glycerides , content of which exceeded 3- and more-fold the initial one to the end of a day . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
45,
51
]
} | {
"id": "C0017860",
"name": "glycerides",
"pos": [
76,
86
]
} |
the similarity was observed in alteration of triacyl glycerides , phospho- and glycolipids in presence of both lipid preparations . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
53,
63
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
111,
116
]
} |
serological investigations gave no evidence of disseminated immune vasculitis , systemic lupus erythematosus or any other autoimmune disease . | NA | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
80,
108
]
} | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
122,
140
]
} |
it is possible to solve most of the problems of differential diagnosis ( primarily distinguishing between cyst and tumour ) by means of renal angiography and sonography . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
106,
110
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
115,
121
]
} |
in distal ( type 1 ) rta , renal acid excretion is impaired by the inability to establish adequate ph gradients between plasma and distal tubular fluid at any level of acidosis . | NA | {
"id": "C0001126",
"name": "rta",
"pos": [
21,
24
]
} | {
"id": "C0001122",
"name": "acidosis",
"pos": [
168,
176
]
} |
the effects of exogenous prostaglandin e ( 1 ) ( pge ( 1 ) ) or prostaglandin e ( 2 ) ( pge ( 2 ) ) were studied in the isolated perfused rat liver and in the intact canine liver in order to determine the possible physiological role of prostaglandins on hepatic carbohydrate and lipid metabolism . | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
25,
40
]
} | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
236,
250
]
} |
based on the histological evaluation of liver biopsy specimens from 18 patients , 6 of whom died with cirrhosis and liver failure , we speculate that liver disease in this condition is caused by protoporphyrin deposits in hepatobiliary structures . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
102,
111
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
150,
163
]
} |
two one-injection insulin regimens -- a combination of intermediate-action nph insulin with regular insulin and a combination of long-acting pzi insulin with regular insulin , all of porcine origin and manufactured by nordisk insulin laboratories -- were compared to a group of 10 juvenile diabetics , each child serving... | NA | {
"id": "C0021658",
"name": "nph",
"pos": [
75,
78
]
} | {
"id": "C0304870",
"name": "long-acting",
"pos": [
129,
140
]
} |
because of its insidious nature , intramuscular bleeding , in contrast to hemarthrosis , is missed or belatedly recognized in hemophiliacs . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
48,
56
]
} | {
"id": "C0018924",
"name": "hemarthrosis",
"pos": [
74,
86
]
} |
uncommon causes of mitral incompetence that may require valve replacement are endocardial fibroelastosis , marfan 's syndrome , calcified mitral anulus , osteogenesis imperfecta , methysergide-induced heart disease and carcinoid heart disease . | NA | {
"id": "C0018799",
"name": "heart disease",
"pos": [
201,
214
]
} | {
"id": "C0007093",
"name": "carcinoid heart disease",
"pos": [
219,
242
]
} |
sickle cell anemia patients treated with 150 iu vitamin e ( dl-alpha-tocopheryl acetate ) three times a day for 1 to 2 months had plasma tocopherol levels similar to control subjects . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
48,
57
]
} | {
"id": "C0994472",
"name": "dl-alpha-tocopheryl acetate",
"pos": [
60,
87
]
} |
the hormone antibodies are applied to deparaffinized tissue sections as the primary specific immune sera using the standard peroxidase technic . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
12,
22
]
} | {
"id": "C0020960",
"name": "immune sera",
"pos": [
93,
104
]
} |
the data indicate that percutaneous needle biopsy of the parietal pleura is less efficacious in the diagnosis of malignant pleural disease than is cytologic evaluation of the fluid sediment , whereas in the diagnosis of tuberculous pleurisy , pleural biopsy proved superior . | NA | {
"id": "C0032226",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0041326",
"name": "tuberculous pleurisy",
"pos": [
220,
240
]
} |
the authors conclude that the combined esterase reaction can distinguish among acute granulocytic leukemia , acute monocytic leukemia , and acute myelomonocytic leukemia . | NA | {
"id": "C0023467",
"name": "acute granulocytic leukemia",
"pos": [
79,
106
]
} | {
"id": "C0023465",
"name": "acute",
"pos": [
140,
145
]
} |
utilizing the criteria of whitehead , et al , atrophic gastritis was diagnosed histologically in three of four patients with diffuse gastritis but in one of those considered to have circumscribed atrophic gastritis . | NA | {
"id": "C0017152",
"name": "gastritis",
"pos": [
55,
64
]
} | {
"id": "C0017154",
"name": "atrophic gastritis",
"pos": [
196,
214
]
} |
in addition , the pulmonary disease developed in the absence of underlying chronic hepatic disease or extrahepatic portal vein thrombosis which , reportedly , can lead to pulmonary hypertension . | NA | {
"id": "C0024115",
"name": "pulmonary disease",
"pos": [
18,
35
]
} | {
"id": "C0020542",
"name": "pulmonary",
"pos": [
171,
180
]
} |
2 ) more children with brain tumors had a sibling with epilepsy or seizures than did normal children , and several of the mothers of children with brain tumors had themselves had epilepsy or a stroke at a relatively young age ; | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
67,
75
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
179,
187
]
} |
surveillance for influenza virus infections began in mid-1976 , continued through three small influenza a outbreaks ( mixed a/victoria and a/texas outbreaks in spring , 1977 , and winter , 1977-1978 and an a/ussr outbreak peaking in march , 1978 ) . | NA | {
"id": "C0029342",
"name": "influenza virus infections",
"pos": [
17,
43
]
} | {
"id": "C0021400",
"name": "influenza",
"pos": [
94,
103
]
} |
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