text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
tay-sachs disease and related gm2 ganglioside storage disorders result from the absence of one form of hexosaminidase , hex a . | NA | {
"id": "C0005270",
"name": "hexosaminidase",
"pos": [
103,
117
]
} | {
"id": "C0162330",
"name": "hex a",
"pos": [
120,
125
]
} |
using immunologic and biochemical techniques , it has been demonstrated that the two major isozymes of hexosaminidase , hex a and hex b , share a common subunit , the structure of hex a being designated ( alpha beta ) n and the structure of hex b being designated as ( beta2 ) n . | NA | {
"id": "C0005270",
"name": "hexosaminidase",
"pos": [
103,
117
]
} | {
"id": "C0162330",
"name": "hex a",
"pos": [
180,
185
]
} |
using immunologic and biochemical techniques , it has been demonstrated that the two major isozymes of hexosaminidase , hex a and hex b , share a common subunit , the structure of hex a being designated ( alpha beta ) n and the structure of hex b being designated as ( beta2 ) n . | NA | {
"id": "C0005270",
"name": "hexosaminidase",
"pos": [
103,
117
]
} | {
"id": "C0019481",
"name": "hex b",
"pos": [
241,
246
]
} |
antirheumatic drugs reviewed are salicylates ( including aspirin , sodium salicylate , choline salicylate , choline magnesium salicylate , salsalate ) , phenylpropionic acid derivatives ( fenoprofen , ibuprofen , naproxen ) , indole derivatives ( sulindac , tolmetin and indomethacin ) , pyrazolone derivatives ( phenylb... | NA | {
"id": "C0036077",
"name": "salicylates",
"pos": [
33,
44
]
} | {
"id": "C0004057",
"name": "aspirin",
"pos": [
57,
64
]
} |
antirheumatic drugs reviewed are salicylates ( including aspirin , sodium salicylate , choline salicylate , choline magnesium salicylate , salsalate ) , phenylpropionic acid derivatives ( fenoprofen , ibuprofen , naproxen ) , indole derivatives ( sulindac , tolmetin and indomethacin ) , pyrazolone derivatives ( phenylb... | NA | {
"id": "C0036077",
"name": "salicylates",
"pos": [
33,
44
]
} | {
"id": "C0073983",
"name": "salsalate",
"pos": [
139,
148
]
} |
antirheumatic drugs reviewed are salicylates ( including aspirin , sodium salicylate , choline salicylate , choline magnesium salicylate , salsalate ) , phenylpropionic acid derivatives ( fenoprofen , ibuprofen , naproxen ) , indole derivatives ( sulindac , tolmetin and indomethacin ) , pyrazolone derivatives ( phenylb... | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
313,
327
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
330,
345
]
} |
as the disease progresses , aspirin remains the drug of choice for antiinflammatory activity but the phenylpropionic acid or indole derivatives may be preferred in patients unable to tolerate salicylates . | NA | {
"id": "C0004057",
"name": "aspirin",
"pos": [
28,
35
]
} | {
"id": "C0036077",
"name": "salicylates",
"pos": [
192,
203
]
} |
based upon the frequency of gallstones over the age of 10 , the likelihood of symptoms or serious complications and the apparent ease with which the properly prepared sickle cell patient comes through surgery , we recommend routine cholecystograms in all adolescent and adult sickle cell anemia patients with elective ch... | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
28,
38
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
353,
359
]
} |
the effects of estrone , estradiol-17beta , estriol , testosterone , progesterone , and 20alpha-dihydroprogesterone on incorporation of 3h-thymidine into cultured lymphocytes from normal men and nonpregnant women in response to allogeneic stimulation was investigated with two-way mlr . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
69,
81
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
96,
115
]
} |
sera from lifetime residents in 16 localities of the indo-australian archipelago and adjacent areas were tested for hemagglutination-inhibition antibody against four alpha-viruses ( sindbis , getah , chikungunya , and ross river ) and for neutralizing antibody against six flaviviruses ( dengue 2 and 3 , japanese enceph... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
144,
152
]
} | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
239,
260
]
} |
the maintainance of body weight occurred despite alterations at the level of the intestinal brush border as indicated by a depression of intestinal disaccharidase activities ( sucrase and lactase ) and by reduction of monosaccharide absorption ( measured as accumulation of beta-methyl glucoside ) in the proximal , heav... | NA | {
"id": "C0012610",
"name": "disaccharidase",
"pos": [
148,
162
]
} | {
"id": "C0038634",
"name": "sucrase",
"pos": [
176,
183
]
} |
the predominant amino acid in shell hydrolysates was found to be glycine , which accounted for 37 % of s. mansoni and 45 % of s. japonicum amino acids . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
65,
72
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
139,
150
]
} |
four components ( glycine , aspartic acid , lysine , and serine ) totalled 68 -- 75 % of amino acids in the eggshells . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
18,
25
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
89,
100
]
} |
carbohydrates were estimated to comprise 7.5 -- 10 % of the eggshell weight , based on hexose assay , and glucosamine was identified as the principal amino sugar in shell hydrolysates . | NA | {
"id": "C0007004",
"name": "carbohydrates",
"pos": [
0,
13
]
} | {
"id": "C0002531",
"name": "amino sugar",
"pos": [
150,
161
]
} |
a new form of abdominal zygomycosis different from mucormycosis : report of two cases and review of the literature . | NA | {
"id": "C0043541",
"name": "zygomycosis",
"pos": [
24,
35
]
} | {
"id": "C0026718",
"name": "mucormycosis",
"pos": [
51,
63
]
} |
the effects of pentobarbital on survival times of mice exposed to oxygen , 5 per cent , were studied over a large dosage range in normal mice and in mice made tolerant to the effect of barbiturates . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
15,
28
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
185,
197
]
} |
this shift was not explained by lower brain concentrations of pentobarbital in tolerant animals , but rather parallelled the increased tolerance to the anesthetic effect of the barbiturate . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
62,
75
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
177,
188
]
} |
the authors studied the effects of substituting deuterium for hydrogen in several volatile anesthetics on their metabolism in the fischer rat . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
48,
57
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
62,
70
]
} |
total replacement of hydrogen by deuterium resulted in a 29 per cent decrease in the amount of fluoride produced , while deuteration of only the methoxyl group produced a 33 per cent decrease in fluoride produced . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
21,
29
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
33,
42
]
} |
the authors believe atropine and atropine derivatives deserve ongoing investigation , especially regarding potential side effects of retarding mucociliary clearance and the clinical significance of apparent failure to dilate small airways . | NA | {
"id": "C0004259",
"name": "atropine",
"pos": [
20,
28
]
} | {
"id": "C0004260",
"name": "atropine derivatives",
"pos": [
33,
53
]
} |
the quantitative effects of theophylline anhydrous upon exercise-induced asthma ( eia ) were evaluated in asthmatic children . | NA | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
56,
79
]
} | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
106,
115
]
} |
the results suggested differences between allergenic and antigenic capacities which may be based on structural differences of the antigenic determinants . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
42,
52
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
130,
139
]
} |
the results suggested differences between allergenic and antigenic capacities which may be based on structural differences of the antigenic determinants . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
57,
66
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
130,
152
]
} |
passive immunity in transmissible gastroenteritis of swine : immunoglobulin classes of milk antibodies after oral-intranasal inoculation of sows with a live low cell culture-passaged virus . | NA | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
61,
75
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
92,
102
]
} |
twelve arterial and 12 venous preparations all contracted dose dependently when epinephrine , norepinephrine , serotonin , or histamine were added to the bathing fluid . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
80,
91
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
94,
108
]
} |
however , when hydrocortisone or betamethasone was added to vessel strips that were partially contracted ( 40 % to 60 % maximal ) by epinephrine , norepinephrine , or serotonin , each vessel strip invariably underwent an additional contraction . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
133,
144
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
147,
161
]
} |
the degree of corticosteroid/amine potentiation was greater for epinephrine than for norepinephrine and greater in the digital vein than in the corresponding artery from the same animal . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
64,
75
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
85,
99
]
} |
a more sensitive procedure utilizing gas-liquid chromatography revealed that , of the substrates tested , the following were bein hydrolyzed : bovine and egg yolk phosphatidyl choline , lysophosphatidyl choline , alpha-palmito-beta-eleoyl-l-alpha lecithin and alpha-oleoyl-betal-palmitoyl-l-alpha lecithin . | NA | {
"id": "C1959616",
"name": "phosphatidyl choline",
"pos": [
163,
183
]
} | {
"id": "C0031617",
"name": "lecithin",
"pos": [
297,
305
]
} |
the pahtophysiology depends upon physical invasion of hair , lint , and other foreign material into the subcutaneum and the formation of a foreign body reaction . | NA | {
"id": "C0016542",
"name": "foreign material",
"pos": [
78,
94
]
} | {
"id": "C0016549",
"name": "foreign body reaction",
"pos": [
139,
160
]
} |
a clinical comparison of the effect of piloplex ( an emulsion containing a new pilocarpine polymer compound ) to that of pilocarpine hydrochloride 2 % q.i.d.hloride on the intraocular pressure ( iop ) was performed on 93 eyes of 51 open-angle glaucoma cases . | NA | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
79,
90
]
} | {
"id": "C0770456",
"name": "pilocarpine hydrochloride",
"pos": [
121,
146
]
} |
the plasma creatine phosphate ( cp ) level showed a tendency to decrease when the atp level dropped in anaphylactic shock , although the cp level did not recover to the same extent as the atp level . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
11,
19
]
} | {
"id": "C0031634",
"name": "cp",
"pos": [
137,
139
]
} |
amongst the latter are included somatotroph adenomas , prolactin cell adenomas , melanocorticotroph adenomas and thyrotroph adenomas . | NA | {
"id": "C0346302",
"name": "somatotroph adenomas",
"pos": [
32,
52
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
124,
132
]
} |
amongst the latter are included somatotroph adenomas , prolactin cell adenomas , melanocorticotroph adenomas and thyrotroph adenomas . | NA | {
"id": "C0033375",
"name": "prolactin cell adenomas",
"pos": [
55,
78
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
124,
132
]
} |
in these cases the culture lipids were characterized by lower content of phospholipids ( 35 -- 45 per cent from the total lipids as compared to 70 -- 80 per cent when grown on the control medium without fats ) and significantly increased content of unsaturated fatty acids ( 3 -- 4 times ) . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
27,
33
]
} | {
"id": "C0015677",
"name": "fats",
"pos": [
203,
207
]
} |
aminoglycoside phosphotransferase was isolated from the mycelium of act . fradiae , the neomycin-producing organism , with paromomycin , neomycin and to a less extent ribostamycin being substrates of aminoglycoside-phosphotransferase . | NA | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
123,
134
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
137,
145
]
} |
aminoglycoside phosphotransferase was isolated from the mycelium of act . fradiae , the neomycin-producing organism , with paromomycin , neomycin and to a less extent ribostamycin being substrates of aminoglycoside-phosphotransferase . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
88,
96
]
} | {
"id": "C0035554",
"name": "ribostamycin",
"pos": [
167,
179
]
} |
the maximum activity of the enzyme preparations was observed at ph 7.7 -- 7.8 ; km for neomycin and paromomycin was about 20 micron and km for atp was 150 micron . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
87,
95
]
} | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
100,
111
]
} |
the findings of the elementary analysis of neomycin phosphate showed the presence of 1 mole of phosphorus per 1 mole of the antibiotic . | NA | {
"id": "C0013879",
"name": "elementary",
"pos": [
20,
30
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
95,
105
]
} |
[ comparison of the action of carminomycin and rubomycin on the dynamics of the primary and secondary immune responses ] . | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
30,
42
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
47,
56
]
} |
the effect of rubomycin and carminomycin on the dynamics of the primary and secondary immune response and formation of the immunologic memory to sheep red cells in mice was studied . | NA | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
14,
23
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
28,
40
]
} |
investigation of the properties of antibiotic-resistant variants obtained experimentally from various species of brucella indicated that benzylpenicillin , ampicillin and ceporin induced significant changes in the main properties of brucella , i.e . phagolysability , agglutinability , production of brucellacin and hydr... | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
137,
153
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
156,
166
]
} |
the determination of the lipid a content of bacterial lipopolysaccharide by using a dim mutant of the luminous bacterium beneckea harveyi is described . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
25,
32
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
54,
72
]
} |
we suggest that this is a further family with immune deficiency presenting with common variable immunodeficiency and lymphoid malignancy . | NA | {
"id": "C0021051",
"name": "immune deficiency",
"pos": [
46,
63
]
} | {
"id": "C0009447",
"name": "common variable",
"pos": [
80,
95
]
} |
blunt trauma occurred in 46 patients ( 24 % ) , low velocity gunshot wounds in 82 patients ( 43 % ) , shotgun wounds in 22 patients ( 12 % ) , stab wounds in 20 patients ( 10 % ) , iatrogenic injury in nine patients ( 5 % ) , high velocity gunshot wounds in two patients ( 1 % ) and other penetrating wounds in ten patie... | NA | {
"id": "C0043255",
"name": "stab wounds",
"pos": [
143,
154
]
} | {
"id": "C0043254",
"name": "penetrating wounds",
"pos": [
289,
307
]
} |
blunt trauma occurred in 46 patients ( 24 % ) , low velocity gunshot wounds in 82 patients ( 43 % ) , shotgun wounds in 22 patients ( 12 % ) , stab wounds in 20 patients ( 10 % ) , iatrogenic injury in nine patients ( 5 % ) , high velocity gunshot wounds in two patients ( 1 % ) and other penetrating wounds in ten patie... | NA | {
"id": "C0043252",
"name": "gunshot wounds",
"pos": [
61,
75
]
} | {
"id": "C0043254",
"name": "penetrating wounds",
"pos": [
289,
307
]
} |
the present study was performed to evaluate scintigraphic imaging with technetium 99m-labeled glucoheptonate and serum enzyme levels of creatine phosphokinase isoenzyme ( mb-cpk ) in the early diagnosis of perioperative acute myocardial infarction associated with saphenous vein bypass graft operations . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
119,
125
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
159,
168
]
} |
the use of internal and external vascular conduits for correction of d-transposition of the great arteries and double-outlet right ventricle with pulmonary atresia . | NA | {
"id": "C0040761",
"name": "transposition of the great arteries",
"pos": [
71,
106
]
} | {
"id": "C0013069",
"name": "double-outlet right ventricle",
"pos": [
111,
140
]
} |
the patient was restudied because of progressive cyanosis and was diagnosed as having d-transposition of the great arteries and double-outlet right ventricle with pulmonary atresia . | NA | {
"id": "C0040761",
"name": "transposition of the great arteries",
"pos": [
88,
123
]
} | {
"id": "C0013069",
"name": "double-outlet",
"pos": [
128,
141
]
} |
at operation , vein grafts were placed to bypass the aneurysm and the orifice of the left coronary artery was oversewn to exclude the aneurysm from the coronary circulation . | NA | {
"id": "C0002940",
"name": "aneurysm",
"pos": [
53,
61
]
} | {
"id": "C0010051",
"name": "aneurysm",
"pos": [
134,
142
]
} |
( 3 ) transformation of sm cells to leiomyoid cells that resemble both sm cells and fibroblasts ; | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
27,
32
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
84,
95
]
} |
lack of history of injury and insidious onset suggested neoplasia , but the morphology was that of a reactive rather than neoplastic process . | NA | {
"id": "C0027651",
"name": "neoplasia",
"pos": [
56,
65
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
122,
140
]
} |
contrary to a recent report , corneal fibroblasts of patients with macular corneal dystrophy were indistinguishable from control cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
38,
49
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
129,
134
]
} |
from extracts of the excreta , we isolated tetra- and trichlorobenzene with two or three sulphur-containing substituents on the ring , analogous compounds in which thiol groups were converted into sulphoxide and sulphone groups , as well as analogous compounds with a phenolic oxygen in addition to sulphur , and sulphur... | NA | {
"id": "C0038761",
"name": "sulphone",
"pos": [
212,
220
]
} | {
"id": "C0038776",
"name": "sulphur",
"pos": [
313,
320
]
} |
monkey interferon ( mkif ) produced in monkey bsc-1 cells infected with newcastle disease virus showed antiviral activity on human foreskin fibroblasts and rd114cells -- a human line transformed by feline sarcoma virus . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
52,
57
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
140,
151
]
} |
infectious virus could be recovered from the infected cells by co-cultivation with human lung fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
54,
59
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
94,
105
]
} |
the best results are achieved in treatment of sections with pure antibody instead of antisera . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
65,
73
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
85,
93
]
} |
however , an unusually high prevalence of congenital anomalies of the ear and oral cavity , ie , oral clefts , facial paralysis in diabetics , and the absence of otosclerosis , suggest racial inheritance as a predominant factor for their pattern or ear disease . | NA | {
"id": "C0029899",
"name": "otosclerosis",
"pos": [
162,
174
]
} | {
"id": "C0013447",
"name": "ear disease",
"pos": [
249,
260
]
} |
the rates of o2 uptake in the presence of glutamine or glutamate are sufficient to account for the formation of the carbon skeleton of alanine from the amino acid substrate , i.e . the ratio of o2 used/alanine formed is greater than 1.5 . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
152,
162
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
202,
209
]
} |
daily intramuscular injections of clofibrate begun 6h before the initiation of inflammation induced by the subcutaneous injection of turpentine exerted a differential , dose-dependent inhibition of the anticipated acute-phase globulin response . | NA | {
"id": "C0021368",
"name": "inflammation",
"pos": [
79,
91
]
} | {
"id": "C0001349",
"name": "acute-phase",
"pos": [
214,
225
]
} |
2,4-diamino-5-methyl-6- [ ( 3,4,5-trimethoxyanilino ) methyl ] quinazoline ( tmq ) , a potent non-classical folate antagonist inhibitor -- i effect on dihydrofolate reductase and growth of rodent tumors in vitro and in vivo . | NA | {
"id": "C0034407",
"name": "quinazoline",
"pos": [
63,
74
]
} | {
"id": "C0085176",
"name": "tmq",
"pos": [
77,
80
]
} |
sera from patients with felty 's syndrome ( fs ) and rheumatoid arthritis ( ra ) were examined for the presence of circulating immune complexes ( ic ) by using the 125i-c1q binding and monoclonal rheumatoid factor ( mrf ) techniques . | NA | {
"id": "C0015773",
"name": "felty 's syndrome",
"pos": [
24,
41
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
53,
73
]
} |
of 15 patients with fs , 9 ( 60 % ) had high 125i-c1q binding as compared to 3 of 26 ra patients ( 12 % ) . | NA | {
"id": "C0015773",
"name": "fs",
"pos": [
20,
22
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
85,
87
]
} |
the average c1q binding was significantly higher in the fs patients than in the ra patients without fs . | NA | {
"id": "C0003873",
"name": "ra",
"pos": [
7,
9
]
} | {
"id": "C0015773",
"name": "fs",
"pos": [
100,
102
]
} |
c1q binding in both fs and ra patients was significantly higher than a group of 90 normal controls . | NA | {
"id": "C0015773",
"name": "fs",
"pos": [
20,
22
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
27,
29
]
} |
in addition , serum c4 levels were significantly lower in the fs patients than in the ra patients . | NA | {
"id": "C0015773",
"name": "fs",
"pos": [
62,
64
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
86,
88
]
} |
in contrast to these findings , ic levels in fs and ra patients were very similar when measured by the mrf technique . | NA | {
"id": "C0015773",
"name": "fs",
"pos": [
45,
47
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
52,
54
]
} |
these studies indicate that fs patients have higher levels of complement-fixing ic in their sera than ra patients without fs . | NA | {
"id": "C0003873",
"name": "ra",
"pos": [
94,
96
]
} | {
"id": "C0015773",
"name": "fs",
"pos": [
122,
124
]
} |
the incidence of positive ana , rheumatoid factors , immune complexes , and antibodies to intestinal flora was the same in both groups . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
53,
69
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
76,
86
]
} |
we conclude from this study that urate binding to serum albumin is not an important determinant of the renal clearance of uric acid , and by inference there is no significant binding of urate to serum albumin in vivo . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
56,
63
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
195,
208
]
} |
human peripheral neutrophils generated superoxide radicals as assessed by ferricytochrome c reduction in response to activation by the synthetic chemotactic factor , n-formyl-methionyl-leucyl-phenylalanine . | NA | {
"id": "C0008013",
"name": "chemotactic factor",
"pos": [
145,
163
]
} | {
"id": "C0027229",
"name": "n-formyl-methionyl-leucyl-phenylalanine",
"pos": [
166,
205
]
} |
the lipid -- lipoprotein analysis showed that serum and ldl cholesterol concentrations in the 13 hypercholesterolemic children and their parents were significantly higher compared to controls ( children and parents ) . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
4,
9
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
13,
24
]
} |
in conclusion the results of our study stress the importance of determining the lipid -- lipoprotein composition , rather then merely evaluating total serum cholesterol in order to make a correct diagnosis of the hypercholesterolemic state . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
80,
85
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
89,
100
]
} |
the arterial walls of 3 cholesterol-fed rabbits were exposed for 3 -- 4 hours in vivo to homologous cholesterol-labelled plasma with a 20-fold higher [ 3h/14c ] ratio in esterified cholesterol ( ec ) than in free cholesterol ( fc ) . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
24,
35
]
} | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
170,
192
]
} |
influence of oral polyunsaturated and saturated phospholipid treatment on the lipid composition and fatty acid profile of chimpanzee lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
55,
60
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
133,
145
]
} |
the diets of experimental groups were supplemented additionally with either aspirin , phenylbutazone , mefenamic acid , flufenamic acid , oxyphenylbutazone or aminopyrine . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
86,
100
]
} | {
"id": "C0030078",
"name": "oxyphenylbutazone",
"pos": [
138,
155
]
} |
phenylbutazone , flufenamic acid and oxyphenylbutazone produced significant reductions in atherosclerotic plaque formation without major changes in blood cholesterol levels or blood cholesterol -- phospholipid ratios . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
0,
14
]
} | {
"id": "C0030078",
"name": "oxyphenylbutazone",
"pos": [
37,
54
]
} |
the mean ( +/- se ) 3-methylhistidine excretion in patients fed an egg protein diet ( devoid of meat protein ) was 256 +/- 35 mumoles/day and decreased to 190 +/- 14 mumoles/day during fasting . | NA | {
"id": "C0013700",
"name": "egg protein",
"pos": [
67,
78
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
101,
108
]
} |
these observations confirm the previous suggestion that while brain serotonin synthesis depends on the plasma trp/lnaa ratio ( which varies inversely with the proportion of protein to total calories in the diet ) , gut serotonin synthesis depends largely on the trp/lnaa ratio in the dietary protein itself ( and , proba... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
173,
180
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
284,
299
]
} |
three subjects restudied following the ingestion of an equivalent amount of chloride administered as nacl , failed to demonstrate a significant rise in unav . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
76,
84
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
101,
105
]
} |
photosynthetically active vesicles with attached phycobilisomes from anabaena variabilis , were isolated and shown to transfer excitation energy from phycobiliproteins to f696 chlorophyll ( photosystem ii ) . | NA | {
"id": "C0136979",
"name": "phycobilisomes",
"pos": [
49,
63
]
} | {
"id": "C0070980",
"name": "phycobiliproteins",
"pos": [
150,
167
]
} |
this reaction was driven by photosystem ii , and did not involve photo-system i-generated superoxide or peroxide . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
90,
100
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
104,
112
]
} |
using the valinomycin-stimulated k+-atpase and h+ accumulation as an index , the sequence for anion permeation was no-3 greater than br- greater than cl- greater than i- greater than acetate approximately isethionate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
94,
99
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
210,
211
]
} |
effectiveness of labeling of the surface membrane of intact erythrocytes after incubation with [ 125i ] ddisa was assessed by th ratio of 125i incorporated into membrane proteins compared to intracellular proteins . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
161,
178
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
205,
213
]
} |
the vesicles have a functional anion transprot system since they display sulfate transport that is inhibited by the fluorescent probe 8-anilinonaphthalene 1-sulfonate ( ans ) with similar potency as in red cells . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
31,
36
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
73,
80
]
} |
anionic drugs : di- and trinitro-phenols , indomethacin and octanoic acid did not affect the total number of beta-adrenergic receptor sites and , with the exception of trinitrophenol , did not change the association constant for alprenolol but they abolished the stimulation of adenylate cyclase by isoproterenol , fluor... | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
0,
7
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
315,
323
]
} |
membranes prepared from 10-day-old rats contained 32 % protein , 43 % lipid and 25 % carbohydrate with lactase and maltase estimated to comprise in excess of 10 % and 2 % , respectively , of the membrane protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
55,
62
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
195,
211
]
} |
an antibody against the major rnaase ( component b ) reacted with the major rnaase to form a single precipitin line on double immunodiffusion and inhibited the activity of the major rnaase but did not cross-react with the other three components and bovine pancreatic rnaase a . | NA | {
"id": "C0014241",
"name": "rnaase",
"pos": [
30,
36
]
} | {
"id": "C0035541",
"name": "pancreatic rnaase",
"pos": [
256,
273
]
} |
mitochondrial alanine aminotransferase l-alanine:2-oxoglutarate aminotransferase , ec 2.6.1.2 ) has been isolated in homogeneous form from both porcine liver and kidney cortex , but in low yield . | NA | {
"id": "C0001899",
"name": "alanine aminotransferase",
"pos": [
14,
38
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
64,
80
]
} |
d-penicillamine disulfide can be substituted for oxidized glutathione and the mixed disulfide of cysteine and glutathione can serve as the sole substrate giving as one product of interchange , oxidized glutathione . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
58,
69
]
} | {
"id": "C0061516",
"name": "oxidized",
"pos": [
193,
201
]
} |
arylsulfatase c ( aryl-sulfate sulfohydrolase , ec 3.1.6.1 ) from sheep brain acetone powder was solubilized with the chaotropic agent , kscn . | NA | {
"id": "C0052456",
"name": "arylsulfatase c",
"pos": [
0,
15
]
} | {
"id": "C0003940",
"name": "aryl-sulfate sulfohydrolase",
"pos": [
18,
45
]
} |
the neutrophile elastase was found to differ from porcine pancreatic elastase in its specificity towards insulin b chain . | NA | {
"id": "C0064833",
"name": "neutrophile elastase",
"pos": [
4,
24
]
} | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
58,
77
]
} |
the neutrophile elastase preferred mostly valine near the cleaved bond in contrast to pancreatic elastase which preferred alanine as well as valine near the cleaved bond . | NA | {
"id": "C0064833",
"name": "neutrophile elastase",
"pos": [
4,
24
]
} | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
86,
105
]
} |
hydrogenase ( hydrogen : ferricytochrome c3 oxidoreductase , ec 1.12.2.1 ) catalyzes three types of reactions , i.e. , ( 1 ) conversion between hydrogen modifications , para-h2 and ortho-h2 , ( 2 ) exchange reaction between hydrogen isotopes , and ( 3 ) reversible oxidoreduction of an electron carrier with h2 and proto... | NA | {
"id": "C0020284",
"name": "hydrogenase",
"pos": [
0,
11
]
} | {
"id": "C0030016",
"name": "oxidoreductase",
"pos": [
44,
58
]
} |
comparison of cholesterol egress from cultured cells enriched with cholesterol ester after exposure to cationized ldl or to ldl and chloroquine . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
14,
25
]
} | {
"id": "C0008387",
"name": "cholesterol",
"pos": [
67,
78
]
} |
amino acid analysis indicated that both the inhibitors contain four cysteine residues and are rich in aspartic acid , glutamic acid , glycine , valine and leucine ; | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
134,
141
]
} |
we have studied the reaction of ferricytochrome c , methemoglobin and metmyoglobin with oh and alcohol radicals ( methanol , ethanol , ethylene glycol and glycerol ) . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
114,
122
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
125,
132
]
} |
the labelled proteins were subsequently separated by two-dimensional gel electrophoresis with an excess of untreated ribosomal proteins from the same species . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
13,
21
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
117,
135
]
} |
similar coelectrophoresis of e. coli 125i-labelled proteins with unlabelled rat liver and wheat germ ribosomal proteins showed the former to overlap with proteins l1 , l11 , l14 , l16 , l19 , l20 and the latter with l2 , l5 , l6 , l15 , l17 from e. coli . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
101,
119
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
154,
162
]
} |
the amino acid composition is distinguished by being relatively rich in threonine , glycine and lysine , but poor in valine , leucine and tyrosine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
84,
91
]
} |
human fibroblasts were labeled by the 125i-lactoperoxidase technique and the sodium dodecyl sulfate soluble proteins examined by two-dimensional gel electrophoresis to determine the charge heterogeneity of the surface proteins and test for differences in surface proteins in several hereditary disorders . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
108,
116
]
} | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
255,
271
]
} |
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