text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
ten cases of primary bone tumours in infants ( 1 osteosarcoma , 3 ewing 's sarcoma , 1 chondroblastoma and 5 angiomatosis ) are reported . | NA | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
49,
61
]
} | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
66,
82
]
} |
the authors believe that bone dysplasia associated with cloverleaf is neither identical with thanatophoric dysplasia nor achondroplasia . | NA | {
"id": "C0039743",
"name": "thanatophoric dysplasia",
"pos": [
93,
116
]
} | {
"id": "C0001080",
"name": "achondroplasia",
"pos": [
121,
135
]
} |
each responder had at least 5 % activity for branched chain alpha-ketoacid dehydrogenase in their mononuclear blood cells and in whole cell fibroblasts from cultured skin when compared to the activity in normal control cells . | NA | {
"id": "C1321301",
"name": "mononuclear blood cells",
"pos": [
98,
121
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
219,
224
]
} |
each responder had at least 5 % activity for branched chain alpha-ketoacid dehydrogenase in their mononuclear blood cells and in whole cell fibroblasts from cultured skin when compared to the activity in normal control cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
140,
151
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
219,
224
]
} |
the concentrations of ala , lys , val , glu , pro , thr , and gly , in descending order , accounted for about 70 % of the amino acids in amniotic fluids . | NA | {
"id": "C0017890",
"name": "gly",
"pos": [
62,
65
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
122,
133
]
} |
women receiving the supplement of 4.0 mg compared with 0.5 mg of vitamin b6 per day had significantly higher plasma pyridoxal phosphate ( p less than .01 ) and breast milk total vitamin b6 concentrations ( p less than .05 ) beginning at 1 month postpartum and continuing through the duration of the study . | NA | {
"id": "C0034263",
"name": "pyridoxal",
"pos": [
116,
125
]
} | {
"id": "C0087162",
"name": "vitamin b6",
"pos": [
178,
188
]
} |
at a concentration of 30 microm , adrenaline markedly augmented the ouabain-sensitive na+-efflux , but other biogenic amines were less effective ( noradrenaline and dopamine ) or ineffective ( histamine and serotonin ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
34,
44
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
147,
160
]
} |
5-methylcytosine represents 2.9 % of the total cytosine in spore dna and is located in approximately the same amount at any of the four ca , ct , cc or cg dinucleotides . | NA | {
"id": "C0049308",
"name": "5-methylcytosine",
"pos": [
0,
16
]
} | {
"id": "C0010843",
"name": "cytosine",
"pos": [
47,
55
]
} |
moreover , viscometry data which clearly exhibited a slight decrease of dna length in the presence of bithiazole derivative led to the proposal of a binding model involving a partial insertion of a thiazole ring which wedges in between the bases at a bending point of dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
23,
24
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
268,
271
]
} |
the rna genome of poliovirus hybridizes to 28s and 18s rrnas of higher eukaryotes under stringent conditions . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
4,
7
]
} | {
"id": "C0035701",
"name": "rrnas",
"pos": [
55,
60
]
} |
southern blot analysis of dna clones of mouse rrna genes leads us to conclude that several regions of 28s rrna , and at least one region in 18s rrna , are involved in the hybridization to polio rna , and that g/c regions are not responsible for this phenomenon . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
46,
50
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
194,
197
]
} |
the ada+ gene product , a dna methyltransferase present in extracts from an escherichia coli strain constitutive for the adaptive response , removes only half of the methyl phosphotriesters from alkylated dna . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
24,
29
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
205,
208
]
} |
the nucleotide sequence of a transposon tn7 dna fragment encoding a 3 '' '' ( 9 ) -o-nucleotidyltransferase , an aminoglycoside-modifying enzyme , which mediates bacterial resistance to spectinomycin and streptomycin , was determined . | NA | {
"id": "C0002556",
"name": "aminoglycosid",
"pos": [
113,
126
]
} | {
"id": "C0001268",
"name": "spectinomyci",
"pos": [
186,
198
]
} |
the nucleotide sequence of a transposon tn7 dna fragment encoding a 3 '' '' ( 9 ) -o-nucleotidyltransferase , an aminoglycoside-modifying enzyme , which mediates bacterial resistance to spectinomycin and streptomycin , was determined . | NA | {
"id": "C0002556",
"name": "aminoglycosid",
"pos": [
113,
126
]
} | {
"id": "C0038425",
"name": "streptomyci",
"pos": [
204,
215
]
} |
treatment of supercoiled pbr322 dna with ozone resulted in the conversion of closed circular dna to open circular dna . | NA | {
"id": "C0012937",
"name": "supercoiled",
"pos": [
13,
24
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
105,
117
]
} |
a sequence that is conserved at around -300 bp in the s-rich prolamins is also conserved at similar locations in genes encoding the two major classes of maize prolamin ( the z19 and z21 zeins ) and appears to be unique to prolamin genes . | NA | {
"id": "C2350325",
"name": "prolamins",
"pos": [
61,
70
]
} | {
"id": "C0043458",
"name": "zeins",
"pos": [
186,
191
]
} |
our results show that the relative amounts of mrna for plp and that for the major extrinsic protein of the myelin membrane , myelin basic protein , increase coordinately during the course of myelination in the brain . | NA | {
"id": "C0026972",
"name": "protein",
"pos": [
92,
99
]
} | {
"id": "C0014063",
"name": "myelin basic protein",
"pos": [
125,
145
]
} |
truncated mouse ribosomal dna ( rdna ) genes were stably incorporated into rat htc-5 cells by dna-mediated cell transfection techniques . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
16,
29
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
94,
97
]
} |
a 68-year-old woman suffering from frequent attacks of supraventricular tachycardia received an implantable , automatic scanning pacemaker for tachycardia termination ( pasar ) . | NA | {
"id": "C0039240",
"name": "supraventricular",
"pos": [
55,
71
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
143,
154
]
} |
from isolates of staphylococcus aureus derived from patients suffering from toxic shock syndrome a toxin was identified by tests in monkeys and was found to be distinct from the enterotoxin responsible for staphylococcal food poisoning . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
99,
104
]
} | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
178,
189
]
} |
in a separate series of experiments adrenal cells were stimulated with ( a ) the cortisol precursor steroids ( all at 10 ( -5 ) mol/l ) pregnenolone , 17-hydroxypregnenolone , progesterone , 17-hydroxyprogesterone and 11-deoxycortisol , ( b ) dibutyryl camp ( 10 ( -3 ) mol/l ) or ( c ) acth ( 100 ng/l ) in the presence... | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
136,
148
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
151,
173
]
} |
in a separate series of experiments adrenal cells were stimulated with ( a ) the cortisol precursor steroids ( all at 10 ( -5 ) mol/l ) pregnenolone , 17-hydroxypregnenolone , progesterone , 17-hydroxyprogesterone and 11-deoxycortisol , ( b ) dibutyryl camp ( 10 ( -3 ) mol/l ) or ( c ) acth ( 100 ng/l ) in the presence... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
176,
188
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
191,
213
]
} |
in general , total cellular nucleic acids are precipitated with either ethanol or isopropanol after lysates , in 3 % w/v nacl , are extracted with a phenol-chloroform mixture . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
71,
78
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
82,
93
]
} |
the rna- containing , plasmid enriched fraction , is once again precipitated with either ethanol or isopropanol , dried in a vacuum , and redissolved . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
89,
96
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
100,
111
]
} |
quantification of aryl hydrocarbon hydroxylase and 7-ethoxycoumarin o-deethylase activity in human placentae : development of a protocol suitable for studying effects of environmental exposures on human metabolism . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
18,
46
]
} | {
"id": "C0000644",
"name": "7-ethoxycoumarin o-deethylase",
"pos": [
51,
80
]
} |
u.s.s.r. and u.s. nutrient intake , plasma lipids , and lipoproteins in men ages 40-59 sampled from lipid research clinics populations . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
56,
68
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
100,
105
]
} |
correlates of high-density lipoprotein ( hdl ) cholesterol and other lipids and lipoproteins were studied in white men ages 40-59 who were part of the 15 % random sample recalled to visit 2 of the lipid research clinics program prevalence study . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
80,
92
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
197,
202
]
} |
the partially purified enzyme did not have any detectable nuclease activity when tested with single-stranded or double-stranded bacteriophage t7 substrate dna and did not have detectable endonuclease activity when tested with bacteriophage m13 viral dna or plasmid pbr322 covalently closed circular dna . | NA | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
112,
127
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
244,
253
]
} |
our findings on apob structure might be important for understanding the role of apob-100-containing lipoproteins in atherosclerosis . | NA | {
"id": "C0003593",
"name": "apob",
"pos": [
16,
20
]
} | {
"id": "C0205666",
"name": "apob-100",
"pos": [
80,
88
]
} |
the third band was of much greater relative intensity in the albumin mrna-specific proteins than in total poly ( a ) messenger ribonucleoprotein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
61,
68
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
83,
91
]
} |
the results suggest that the proteins bound to albumin mrna represent only a subset of the total population of poly ( a ) mrna-associated protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
47,
54
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
138,
145
]
} |
aggregation was blocked by a monoclonal antibody against the platelet membrane glycoprotein , gpib , as well as by an anti-gpiib/iiia antibody . | NA | {
"id": "C0032195",
"name": "platelet membrane glycoprotein",
"pos": [
61,
91
]
} | {
"id": "C0016011",
"name": "gpiib/iiia",
"pos": [
123,
133
]
} |
standardization of lipid and lipoprotein measurements is of concern to laboratories that serve pediatric as well as adult populations , since preventive measures taken during pediatric years can help control atherosclerotic cardiovascular problems that can arise during adult years . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
19,
24
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
29,
40
]
} |
multiple analytical and physiologic problems that exist inherently in the lipids and lipoproteins and in application of measurements to the pediatric population must be controlled to gain standardization and produce highly precise and accurate results . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
74,
80
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
85,
97
]
} |
in collaboration with nhlbi , the cdc has offered lipid and lipoprotein standardization services for the united states since 1957 and , on an international scale , has cooperated with who since 1962 . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
50,
55
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
60,
71
]
} |
before the start of and at the end of treatment with pizotifen , protracted insulin tolerance tests were performed , during which blood glucose and growth hormone ( hgh ) levels were measured ( 10 times over 2 hours ) . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
148,
162
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
165,
168
]
} |
patients were treated topically with either a cream containing the amino acids l-cysteine , glycine and dl-threonine or the cream base alone ( placebo ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
67,
78
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
92,
99
]
} |
due to pergolide mesylate 's action as a postsynaptic dopamine agonist , a dopaminergic neural system is implicated in pergolide induced anorexia . | NA | {
"id": "C0031008",
"name": "pergolide mesylate 's",
"pos": [
7,
28
]
} | {
"id": "C0031007",
"name": "pergolide",
"pos": [
119,
128
]
} |
to test this possibility , various doses of d-ala-2-leu-enk , d-ala-2-met-enk , naloxone and naltrexone were injected into the cdp and gp through chronically implanted cannulae . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
80,
88
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
93,
103
]
} |
the injections of met and leu-enk caused dose-dependent ipsiversive rotations while injections of naloxone and naltrexone caused contraversive rotations . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
98,
106
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
111,
121
]
} |
absorption of cytidine diphosphate choline radioactivity was complete after oral treatment with the low dose and accounted for 94.5 % of the dose when 300 mg/kg of cytidine diphosphate [ methyl-14c ] choline were administered . | NA | {
"id": "C0010725",
"name": "cytidine",
"pos": [
14,
22
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
200,
207
]
} |
as a consequence of these alterations , the hepatic microsomal mixed-function oxidase system was impaired as evidenced by a decrease in cytochrome p-450 content and in the activities of nadph-cytochrome c reductase and aminopyrine-demethylase . | NA | {
"id": "C0003927",
"name": "microsomal mixed-function oxidase",
"pos": [
52,
85
]
} | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
136,
152
]
} |
the cytochrome p-450-dependent aryl hydrocarbon hydroxylase ( ahh ) metabolizes a wide variety of endogenous and exogenous compounds to nontoxic metabolites and/or toxic products . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
4,
20
]
} | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
31,
59
]
} |
we have utilized a series of 18 flavone modulators of ahh to distinguish and probe for different cytochrome p-450 isozymes in liver microsomes from control and 3-methylcholanthrene ( mc ) -injected rats . some flavones ( maackiain acetate , flavanone , mollisacacidin , embinin , sciadopitysin ) activated , while most o... | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
97,
113
]
} | {
"id": "C0003927",
"name": "ahh",
"pos": [
376,
379
]
} |
leukotrienes ( lt ) lta4 , ltb4 , ltc4 , ltd4 and lte4 induced marked contractions of guinea pig lung parenchymal strips mounted in organ baths . | NA | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
0,
12
]
} | {
"id": "C0125631",
"name": "lta4",
"pos": [
20,
24
]
} |
in another experiment , the time dependence of liver gluconeogenesis enzyme ( pepck and fructose-1,6-diphosphatase /fdp-ase/ ) and transaminase ( alanine and aspartate aminotransferase /alt , ast/ ) activities during 24 days ' administration of the diet were determined . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
131,
143
]
} | {
"id": "C0004002",
"name": "aspartate",
"pos": [
158,
167
]
} |
a transient delirium , including hallucinations and disorientation , occurred at some time during a 48 to 72 hr postoperative period in patients recovering from elective surgery in an intensive care unit . | NA | {
"id": "C0011206",
"name": "delirium",
"pos": [
12,
20
]
} | {
"id": "C0009676",
"name": "disorientation",
"pos": [
52,
66
]
} |
d-amphetamine ( 20 mg ) was administered intravenously in a double-blind design to 17 schizophrenic patients with and without concurrent 3-week lithium carbonate pretreatment to evaluate the lithium attenuation of d-amphetamine effects which we had observed in affective disorder patients . | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
0,
13
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
216,
227
]
} |
d-amphetamine ( 20 mg ) was administered intravenously in a double-blind design to 17 schizophrenic patients with and without concurrent 3-week lithium carbonate pretreatment to evaluate the lithium attenuation of d-amphetamine effects which we had observed in affective disorder patients . | NA | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
144,
161
]
} | {
"id": "C0023870",
"name": "lithium",
"pos": [
191,
198
]
} |
the authors measured plasma fluphenazine levels in 20 schizophrenic patients receiving 25 or 50 mg fluphenazine decanoate ( fpz-d ) by im injection every 2 weeks . | NA | {
"id": "C0016368",
"name": "fluphenazine",
"pos": [
28,
40
]
} | {
"id": "C0060580",
"name": "fluphenazine decanoate",
"pos": [
99,
121
]
} |
based on the study of plasma levels achieved with fpz-d injection and oral fpz-h ( fluphenazine hc1 ) in 6 patients , the dosage requirement of fpz-d appeared to be difficult to predict from the oral dosage of fpz-h in the same patient . | NA | {
"id": "C0016368",
"name": "fluphenazine",
"pos": [
83,
95
]
} | {
"id": "C0060580",
"name": "fpz-d",
"pos": [
144,
149
]
} |
if the criteria concerning formal thought disorders and affective blunting of the schizophrenic axial syndrome or of sans ( andreasen ) are fulfilled , as a rule the patient loses the ability of perceiving , communicating , and coping with the disorders , and at the same time there is a break from an only quantitative ... | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
102,
110
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
244,
253
]
} |
two instruments were used for evaluation concerning thought and language disorders : the 'scale for assessment of thought , language and communication ' developed by andreasen and the 'endogenomorphic schizophrenic axial syndrome ' by berner with its emphasis on thought disorders . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
221,
229
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
271,
280
]
} |
both spondylitis and spondylodiscitis may also be produced by fungi that can be histologically identified . | NA | {
"id": "C0038012",
"name": "spondylitis",
"pos": [
5,
16
]
} | {
"id": "C0012624",
"name": "spondylodiscitis",
"pos": [
21,
37
]
} |
after progressive destruction and narrowing of the intervertebral disks , spondylitis and spondylodiscitis results in subluxation and fusion of vertebral bodies and square anterior corners . | NA | {
"id": "C0038012",
"name": "spondylitis",
"pos": [
74,
85
]
} | {
"id": "C0012624",
"name": "spondylodiscitis",
"pos": [
90,
106
]
} |
bacteriology , however , was positive in only 5 out of 23 cases with spondylitis or spondylodiscitis . | NA | {
"id": "C0038012",
"name": "spondylitis",
"pos": [
69,
80
]
} | {
"id": "C0012624",
"name": "spondylodiscitis",
"pos": [
84,
100
]
} |
with this technique , nonuniform fatty infiltration of the liver can be differentiated from hepatic metastases , and the technique may prove useful in the differentiation of some hepatic disorders . | NA | {
"id": "C0015695",
"name": "fatty infiltration of",
"pos": [
33,
54
]
} | {
"id": "C0023895",
"name": "hepatic disorders",
"pos": [
179,
196
]
} |
the frequency with which hyperemia was present in association with cartilage damage and synovitis indicates that osteoarthritis of the knee is capable of producing hyperemia and further implies that increased perfusion can not be used to distinguish with confidence between osteoarthritis and septic processes involving ... | NA | {
"id": "C0409959",
"name": "osteoarthritis of the knee",
"pos": [
113,
139
]
} | {
"id": "C0029408",
"name": "osteoarthritis",
"pos": [
274,
288
]
} |
quantification of the hydroxyeicosatetraenoic and hydroxyeicosapentaenoic acids ( hetes ; hepes ) in the lesional skin of psoriatic patients demonstrated that , of the metabolites measured , 12-hete was present in the greatest amounts . | NA | {
"id": "C0020349",
"name": "hetes",
"pos": [
82,
87
]
} | {
"id": "C0044800",
"name": "12-hete",
"pos": [
191,
198
]
} |
we studied the molecular forms of somatostatin-like immunoreactivity ( sli ) , newly released from isolated perfused preparations of the porcine antrum , stomach , pancreas and upper small intestine : perfusion effluents were concentrated by sep-pak c-18 adsorption , eluted with ethanol , dessicated , and subjected to ... | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
373,
388
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
404,
419
]
} |
all the sli newly released from the stomach and antrum eluted at the position of somatostatin-14 , and such was also the case for more than 95 % of the sli newly released from the pancreas , while 68 -/+ 7 % and 75 -/+ 8 % of the sli newly released from the isolated perfused jejunum and ileum , respectively , correspon... | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
81,
96
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
327,
342
]
} |
adsorption of anionic chloro complexes of 59fe and 195au on non-ionic resins of macro-reticular type . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
14,
21
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
64,
69
]
} |
the molar ratio of excitatory amino acid neurotransmitters ( glutamate and aspartate ) to inhibitory amino acid neurotransmitters ( r-aminobutyric acid , gaba , and glycine ) in the brain was diminished in acute hepatic failure rats with hyperammonemia , brain edema , and abnormal electroencephalograms . | NA | {
"id": "C0243046",
"name": "excitatory amino acid",
"pos": [
19,
40
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
101,
111
]
} |
the molar ratio of excitatory amino acid neurotransmitters ( glutamate and aspartate ) to inhibitory amino acid neurotransmitters ( r-aminobutyric acid , gaba , and glycine ) in the brain was diminished in acute hepatic failure rats with hyperammonemia , brain edema , and abnormal electroencephalograms . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
30,
40
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
165,
172
]
} |
considering studies on discontinuation of maintenance digoxin therapy in general practice and also the findings in this study it is suggested that the use of digitalis glycosides in the egilsstadir health district and in iceland could be even lower . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
54,
61
]
} | {
"id": "C0012253",
"name": "digitalis glycosides",
"pos": [
158,
178
]
} |
the histological criteria of condyloma and cervical intra-epithelial neoplasia ( dysplasia and cis ) are recalled , and relationships between them are discussed . | NA | {
"id": "C0206708",
"name": "cervical intra-epithelial neoplasia",
"pos": [
43,
78
]
} | {
"id": "C0007099",
"name": "cis",
"pos": [
95,
98
]
} |
they observed a significant increase in the serum copper level during the first trimester of at risk pregnancies and the increased serum copper level is maintained from the start and throughout the pregnancy , in high risk pregnancies . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
74,
89
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
198,
207
]
} |
the pathomechanism of the phenomenon , which may lead to the formation of an emphysema of the soft parts via the pneumomediastinum , is discussed , and the possible complications which must be taken into account are pointed out . | NA | {
"id": "C0013990",
"name": "emphysema",
"pos": [
77,
86
]
} | {
"id": "C0025062",
"name": "pneumomediastinum",
"pos": [
113,
130
]
} |
clinical data and lymphoma biopsies were analyzed in 651 patients with non-hodgkin lymphoma in order to describe the prognostic influence of different grades of follicular architecture compared to diffuse architecture . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
18,
26
]
} | {
"id": "C0024305",
"name": "non-hodgkin lymphoma",
"pos": [
71,
91
]
} |
because of the association of pseudo- and true lymphomas with phenytoin it is possible that this lymphoproliferative disorder arose as a result of the treatment with phenytoin , possibly in conjunction with sulthiame . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
47,
56
]
} | {
"id": "C0024314",
"name": "lymphoproliferative disorder",
"pos": [
97,
125
]
} |
a prerequisite for optimum therapy is exact staging of the disease into : uncomplicated early stages with short , self-limiting episodes of pancreatitis : conservative therapy , persistent pain , mainly due to pseudocysts ( diagnosis by morphological tests ) : surgical therapy , advanced painless forms of chronic pancr... | NA | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
140,
152
]
} | {
"id": "C0149521",
"name": "chronic pancreatitis",
"pos": [
307,
327
]
} |
[ accuracy of prenatal weight estimation using ultrasound in the case of birth weights less than 2000 grams ] . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
23,
29
]
} | {
"id": "C0005612",
"name": "birth",
"pos": [
73,
78
]
} |
in this study foetal weight as estimated by ultrasound was compared with the true birth weight of children having a birth weight of less than 2000 g ( n = 105 ) . | NA | {
"id": "C0751992",
"name": "foetal weight",
"pos": [
14,
27
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
122,
128
]
} |
in this study foetal weight as estimated by ultrasound was compared with the true birth weight of children having a birth weight of less than 2000 g ( n = 105 ) . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
21,
27
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
116,
128
]
} |
only in the group less than 1200 g a significant overestimation of foetal weight could be shown by using the weight curve of the population of bonn , whereas the percentage deviation of both weight curves was comparable : when using the curve of bonn 68 % of readings had a deviation of less than 10 % , whereas with the... | NA | {
"id": "C0751992",
"name": "foetal weight",
"pos": [
67,
80
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
191,
197
]
} |
in view of recent interest in the relationship of haematocrit and blood viscosity to hypertension and vascular disease , we have analysed retrospectively the relationship of haematocrit to blood pressure , vascular complications and other variables in 2,381 patients referred to the glasgow blood pressure clinic . | NA | {
"id": "C0020538",
"name": "hypertension",
"pos": [
85,
97
]
} | {
"id": "C0042373",
"name": "vascular disease",
"pos": [
102,
118
]
} |
the dahl rat is used as a model of hypertension that is `` '' sensitive '' '' to dietary salt ( sodium chloride , nacl ) . | NA | {
"id": "C0206136",
"name": "o dieta",
"pos": [
79,
86
]
} | {
"id": "C0037494",
"name": ", na",
"pos": [
112,
116
]
} |
a synthetic 18-amino acid peptide containing two tandem repeats binds to a monoclonal antibody directed to the cs protein of plasmodium vivax and inhibits the interaction of this antibody with the native protein in sporozoite extracts . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
75,
94
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
179,
187
]
} |
hematopoietic progenitor cells able to form colonies of granulocytes or macrophages ( or both ) in semisolid medium in the presence of colony stimulating factor were present in the nonadherent cell population . | NA | {
"id": "C0018956",
"name": "hematopoietic progenitor cells",
"pos": [
0,
30
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
193,
197
]
} |
two patients are described who developed posterior longitudinal ligament ossification following treatment with the synthetic retinoid 13-cis-retinoic acid . | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
125,
133
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic",
"pos": [
134,
149
]
} |
the differences in the rates of absorption , volumes of distribution , distribution half-lives , compartmental kinetics , metabolism and elimination half-lives between individual benzodiazepines are reviewed . | NA | {
"id": "C0018517",
"name": "half-lives",
"pos": [
84,
94
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
111,
119
]
} |
the cytogenetics of 419 patients with amenorrhoea are discussed under headings such as gonadal dysgenesis , monosomy x , chromosome mosaics and the xy female phenotype . | NA | {
"id": "C0018051",
"name": "gonadal dysgenesis",
"pos": [
87,
105
]
} | {
"id": "C0041408",
"name": "monosomy x",
"pos": [
108,
118
]
} |
in this study the effect of vitamin a and retinoic acid on fibroblast growth and collagen accumulation in vitro was examined . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
28,
37
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
42,
55
]
} |
vitamin a and retinoic acid added to balb 3t3 mouse fibroblasts in tissue culture resulted in induction of cell differentiation as manifested by a decrease in cell growth rate , enhanced collagen accumulation , and morphologic differentiation . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
0,
9
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
14,
27
]
} |
the results of this in vitro study suggest that the stimulatory in vivo effect of vitamin a and retinoic acid on collagen accumulation and fibroplasia in healing wounds is due in a major way to fibroblast differentiation and enhanced collagen synthesis . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
82,
91
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
96,
109
]
} |
cariogenicity of isomaltulose ( palatinose ) , sucrose and mixture of these sugars in rats infected with streptococcus mutans e-49 . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
47,
54
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
76,
82
]
} |
oral submucous fibrosis ( osf ) is a disease of the mouth and oropharynx characterised by progressive deposition of collagen leading to severe limitation of movement of the jaw in advanced cases . | NA | {
"id": "C0029172",
"name": "oral submucous fibrosis",
"pos": [
0,
23
]
} | {
"id": "C0026636",
"name": "disease of",
"pos": [
37,
47
]
} |
in both cases , the antibodies were detectable in the platelet enzyme immuno-assay ( elisa ) , while the platelet specific alloantibodies could be ascertained neither in the platelet suspension immunofluorescence test ( psift ) nor in the platelet fixation test ( cft ) due to coexisting potent multispecific hla-antibod... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
20,
30
]
} | {
"id": "C0022144",
"name": "alloantibodies",
"pos": [
123,
137
]
} |
the above enzymes were removed from hemoglobin derived from each species and the order of susceptibility to pgdn-induced methemoglobin formation remained essentially the same with dog greater than guinea pig greater than human = rat . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
36,
46
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
121,
134
]
} |
however , the net rate of pgdn-mediated oxidation of hemoglobin to methemoglobin increased in purified hemoglobin preparations from each species . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
53,
63
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
67,
80
]
} |
kinetic analysis of inhibition of brain and red blood cell acetylcholinesterase and plasma cholinesterase by acephate or methamidophos . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
59,
79
]
} | {
"id": "C0008429",
"name": "plasma cholinesterase",
"pos": [
84,
105
]
} |
the affinity ( as measured by ka values ) of acephate was greater than that of methamidophos to both the ache and the che active sites . | NA | {
"id": "C0001044",
"name": "ache",
"pos": [
105,
109
]
} | {
"id": "C0008429",
"name": "che",
"pos": [
118,
121
]
} |
thus thymectomy and aging give rise to disproportions of splenic t cell sets , and in c3h female mice to a heightened capacity for male skin rejection , both effects being largely abrogated by the tp-5 derivative of thymopoietin . | NA | {
"id": "C0080225",
"name": "tp-5",
"pos": [
197,
201
]
} | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
216,
228
]
} |
although synergy has so far only been studied for rat monoclonal antibodies we also show that it is possible with mouse antibodies or with combinations of mouse and rat antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
54,
75
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
169,
179
]
} |
depending on the magnesium concentration the chromatin of isolated nuclei is present in the two conditions : diffuse ( at 0-1.5 mm mgcl2 ) and condensed ( at 2-5 mm mgcl2 ) . | NA | {
"id": "C0024467",
"name": "magnesium",
"pos": [
17,
26
]
} | {
"id": "C0024472",
"name": "mgcl2",
"pos": [
165,
170
]
} |
results obtained by the indirect immunofluorescence method employing specific monoclonal antibodies show that during the first 24 hours of cultivation in a monolayer there appears another protein of intermediate filaments -- vimentin , which is a characteristic of most mesenchymal cells . | NA | {
"id": "C0021769",
"name": "protein",
"pos": [
188,
195
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
225,
233
]
} |
using immunoenzyme method followed by the cytophotometrical determination of individual protein content in single cells , a comparative analysis was made of albumin contents in hepatocytes of inbred mouse stocks significantly differing in their albumin contents in the blood . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
88,
95
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
245,
252
]
} |
of the 1174 incidents reported during the course of 706,259 dives , decompression sickness and barotraumas were the most prevalent . | NA | {
"id": "C0011119",
"name": "decompression sickness",
"pos": [
68,
90
]
} | {
"id": "C0004760",
"name": "barotraumas",
"pos": [
95,
106
]
} |
the tissue concentrations of a modified nucleoside , pseudouridine , and a normal nucleoside , uridine , were measured with high-performance liquid chromatography . | NA | {
"id": "C0033846",
"name": "pseudouridine",
"pos": [
53,
66
]
} | {
"id": "C0041984",
"name": "uridine",
"pos": [
95,
102
]
} |
the ascending route of infection is responsible for the vast majority of uti , and colonization of the periurethral region by group-specific escherichia coli precedes the development of uti . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
23,
32
]
} | {
"id": "C0042029",
"name": "of uti",
"pos": [
183,
189
]
} |
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