text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these findings were repeated when extracts from infected chick embryo cells containing np , m and ns1 proteins radiolabelled in vivo , were injected into the cytoplasm of oocytes . | NA | {
"id": "C0028612",
"name": "np",
"pos": [
87,
89
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
102,
110
]
} |
the fetal anomalies recognized were isolated malformations ( 14,4 % ) , multiple malformations ( 5,1 % ) , syndromes ( 3,2 % ) and chromosomal anomalies ( 3,9 % ) . | NA | {
"id": "C0000768",
"name": "fetal anomalies",
"pos": [
4,
19
]
} | {
"id": "C0000772",
"name": "multiple malformations",
"pos": [
72,
94
]
} |
41 % of the necropsied infants have at least one malformation and 34 % of the malformed show multiple birth defects . | NA | {
"id": "C0000768",
"name": "malformed",
"pos": [
78,
87
]
} | {
"id": "C0000772",
"name": "multiple birth defects",
"pos": [
93,
115
]
} |
a new lethal skeletal dysplasia is reported in addition to the micromelia this malformed fetus presented spondylocostal dysostosis and multiple internal anomalies including a dandy-walker cyst . | NA | {
"id": "C0000768",
"name": "malformed",
"pos": [
79,
88
]
} | {
"id": "C0000772",
"name": "multiple",
"pos": [
135,
143
]
} |
these pathological findings may reflect a host cell response to various pathological and viral stimuli resulting from immune deficiency owing to infection with htlv-iii/lav . | NA | {
"id": "C0021051",
"name": "immune",
"pos": [
118,
124
]
} | {
"id": "C0019693",
"name": "infection",
"pos": [
145,
154
]
} |
the concentrations of seven amino acids ( aspartate , glutamate , gamma-aminobutyric acid , glycine , glutamine , serine , and taurine ) were determined in brain regions from 17-day-old undernourished offspring and from 35-day-old rehabilitated rats . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
28,
39
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
92,
99
]
} |
in both tests , there were no differences between the two groups in heart rate , systolic and diastolic blood pressure or plasma noradrenaline , adrenaline and dopamine concentrations . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
129,
142
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
145,
155
]
} |
in contrast , lysine as a basic amino acid is found to be correlated with the same transport system as the five neutral amino acids . | NA | {
"id": "C0024337",
"name": "lysine",
"pos": [
14,
20
]
} | {
"id": "C0301714",
"name": "basic amino",
"pos": [
26,
37
]
} |
for proline and hydroxyproline a special control system has to be suggested because of their smaller biological variance in csf than in blood . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
4,
11
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
16,
30
]
} |
contrary to the other amino acids proline and hydroxyproline have a smaller biological variation in csf than in serum . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
34,
41
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
46,
60
]
} |
fatty acids of plasma and erythrocyte membrane sphingomyelin were determined by gas chromatography-mass spectrometry in adrenoleukodystrophy ( ald ) without adrenal insufficiency . | NA | {
"id": "C0162309",
"name": "ald",
"pos": [
143,
146
]
} | {
"id": "C0001623",
"name": "adrenal insufficiency",
"pos": [
157,
178
]
} |
in general , within the the better differentiated tumours ( grade i/ii astrocytomas ) higher concentrations of five neuropeptides ( neuropeptide y , somatostatin , substance p , vasoactive intestinal peptide and cholecystokinin ) were measured in comparison to the poorly differentiated tumours . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
116,
129
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
132,
146
]
} |
3h-thymidine incorporation in malignant cells increased exponentially with time , while 3h-thymidine incorporation in the benignant glia cells and fibroblasts was inhibited . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
40,
45
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
147,
158
]
} |
four cases of glioma , i.e. , two cases of astrocytoma , grade ii , and two cases of glioblastoma , were used as materials . | NA | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
43,
54
]
} | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
85,
97
]
} |
at the light microscopic level , mg2+-atpase activity was observed in the capillary wall and glial cells of both astrocytoma and glioblastoma . | NA | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
113,
124
]
} | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
129,
141
]
} |
in this study , we addressed the contribution of pmnls to hyperalgesia evoked by the peptide chemotactic factors n-formyl-methionyl-leucyl-phenylalanine ( fmlp ) and the anaphylatoxin fragment of the fifth component of the complement pathway ( c5a ) . | NA | {
"id": "C0008013",
"name": "chemotactic factors",
"pos": [
93,
112
]
} | {
"id": "C0027229",
"name": "formyl-methionyl-leucyl-phenylalanine",
"pos": [
115,
152
]
} |
indirect immunoperoxidase staining by the peroxidase-antiperoxidase ( pap ) technique was carried out on 23 human primary intracranial germ-cell tumors ( 17 germinomas , one embryonal carcinoma , one yolk-sac tumor , three teratomas , and one teratoma with embryonal carcinoma ) and on six human primary pineal non-germ-... | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
377,
389
]
} | {
"id": "C0017636",
"name": "glioblastoma multiforme",
"pos": [
400,
423
]
} |
comparative effects of protein , protein hydrolysate and amino acid diets on nitrogen metabolism of normal , protein-deficient , gastrectomized or hepatectomized rats . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
23,
30
]
} | {
"id": "C0033631",
"name": "protein hydrolysate",
"pos": [
33,
52
]
} |
the effects of diets containing protein , protein hydrolysate or an amino acid mixture on nitrogen metabolism of normal and severely protein-deficient rats and on rats after gastrectomy and hepatectomy were compared . | NA | {
"id": "C0033631",
"name": "protein hydrolysate",
"pos": [
42,
61
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
133,
140
]
} |
in normal , protein-deficient and hepatectomized rats , most results were similar for the groups fed protein , protein hydrolysate or amino acid diets , except that urinary ammonia was higher in the group fed the amino acid diet than in the other two groups . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
12,
19
]
} | {
"id": "C0033631",
"name": "protein hydrolysate",
"pos": [
111,
130
]
} |
thirty-six patients undergoing extraoral or combined intraoral and extraoral procedures received penicillin and oxacillin perioperatively , with nine receiving one postoperative dose and 27 receiving an average of seven postoperative doses ( regimen b ) . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
97,
107
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
112,
121
]
} |
a patient who had malignant hyperthermia that apparently was triggered by nitrous oxide anesthesia even though he was premedicated with dantrolene sodium was successfully managed on a separate occasion using dantrolene without nitrous oxide . | NA | {
"id": "C0010977",
"name": "dantrolene sodium",
"pos": [
136,
153
]
} | {
"id": "C0010976",
"name": "dantrolene",
"pos": [
208,
218
]
} |
the cells in these lesions appear to be distinct from myofibroblasts and the high affinity complement binding fibroblasts characterized by bordin et al . ( 1 ) . | NA | {
"id": "C0007634",
"name": "the cells",
"pos": [
0,
9
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
110,
121
]
} |
isozyme mobilities of 5 enzymes were identical in all adult worms examined from both strains . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
0,
7
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
24,
31
]
} |
these stimulatory effects suggest that the ribose moiety of adenosine or guanosine can be transferred to another purine base to form a new nucleoside , and that the purine nucleosides are the immediate precursors of e. histolytica nucleotides . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
60,
69
]
} | {
"id": "C0034136",
"name": "purine nucleosides",
"pos": [
165,
183
]
} |
these stimulatory effects suggest that the ribose moiety of adenosine or guanosine can be transferred to another purine base to form a new nucleoside , and that the purine nucleosides are the immediate precursors of e. histolytica nucleotides . | NA | {
"id": "C0018330",
"name": "guanosine",
"pos": [
73,
82
]
} | {
"id": "C0034136",
"name": "purine nucleosides",
"pos": [
165,
183
]
} |
these stimulatory effects suggest that the ribose moiety of adenosine or guanosine can be transferred to another purine base to form a new nucleoside , and that the purine nucleosides are the immediate precursors of e. histolytica nucleotides . | NA | {
"id": "C0028621",
"name": "nucleoside",
"pos": [
139,
149
]
} | {
"id": "C0034136",
"name": "purine nucleosides",
"pos": [
165,
183
]
} |
the form of periodontitis with onset at puberty and affecting predominantly the first molars and incisors is called juvenile periodontitis ( jp ) . | NA | {
"id": "C0031099",
"name": "periodontitis",
"pos": [
12,
25
]
} | {
"id": "C0031106",
"name": "juvenile periodontitis",
"pos": [
116,
138
]
} |
dogs , surgically implanted with a chronic gastric fistula , were chronically dosed with n-desmethyldiazepam ( 32 mg/kg/day ) in four divided doses to attain n-desmethyldiazepam plasma levels comparable to those observed in dogs dependent on diazepam ( 60 mg/kg/day ) . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
91,
108
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
242,
250
]
} |
the abstinence syndrome observed after abrupt discontinuation of n-desmethyldiazepam was similar to the diazepam abstinence syndrome but differed in several important aspects . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
67,
84
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
104,
112
]
} |
signs of abstinence such as tremor , hot foot walking and twitches and jerks were more frequently observed in n-desmethyldiazepam-dependent dogs than in diazepam-dependent dogs as were decreases in food and water intake and in body weight . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
112,
129
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
153,
161
]
} |
the overall intensity of abstinence , as measured by the diazepam withdrawal abstinence scale , was greater in n-desmethyldiazepam-dependent dogs than in dogs dependent on either lorazepam or diazepam . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
113,
130
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
192,
200
]
} |
plasma levels of n-desmethyldiazepam and oxazepam were nearly equal in dogs dependent on diazepam or on n-desmethyldiazepam and were 4 to 10 times greater than the plasma levels of diazepam or lorazepam in diazepam- or lorazepam-dependent dogs , respectively . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
19,
36
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
206,
214
]
} |
furthermore , the plasma levels of n-desmethyldiazepam and oxazepam declined much more slowly than the levels of diazepam and lorazepam . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
37,
54
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
113,
121
]
} |
these results suggest that physical dependence on diazepam is caused by the accumulation and actions of n-desmethyldiazepam . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
50,
58
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
106,
123
]
} |
these beta-funaltrexamine-insensitive sites appear to interact only with opioid peptides ( [ d-ala2 , d-leu5 ] enkephalin , [ d-ala2 , met5 ] enkephalinamide , tyr-d-ser-gly-phe-leu-thr and [ d-ala2 , mephe4 , gly-ol5 ] enkephalin ) but not with nonpeptide agonists . | NA | {
"id": "C0205753",
"name": "opioid",
"pos": [
73,
79
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
220,
230
]
} |
phenytoin inhibited binding of the dihydropyridine ca channel antagonist [ 3h ] nitrendipine to pc12 membranes ( ki = 31 +/- 3 microm ) by decreasing binding affinity , with no change in the maximal number of binding sites . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
35,
50
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
80,
92
]
} |
these results suggest that the discrete trial shock titration paradigm is suitable for demonstration of the antinociceptive effects of opiate and certain nonopiate analgesics , but not nonsteroidal anti-inflammatory analgesics in the rhesus monkey . | NA | {
"id": "C0002771",
"name": "analgesics",
"pos": [
164,
174
]
} | {
"id": "C1875546",
"name": "nonsteroidal anti-inflammatory analgesics",
"pos": [
185,
226
]
} |
rank order of the maximum increase in the suppressing dose of morphine that each antagonist produced was : naltrexone = win 44,441 greater than beta-funaltrexamine greater than naloxone = buprenorphine greater than mr 2266 greater than diprenorphine . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
107,
117
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
177,
185
]
} |
the benzodiazepines midazolam , chlordiazepoxide , diazepam and n-desmethyldiazepam , the cyclopyrrolone zopiclone and the triazolopyridazine cl 218,872 had qualitatively similar stimulus effects regardless of the type of consequence ( food presentation or stimulus-shock termination ) that maintained responding . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
4,
19
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
20,
29
]
} |
the benzodiazepines midazolam , chlordiazepoxide , diazepam and n-desmethyldiazepam , the cyclopyrrolone zopiclone and the triazolopyridazine cl 218,872 had qualitatively similar stimulus effects regardless of the type of consequence ( food presentation or stimulus-shock termination ) that maintained responding . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
4,
19
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
32,
48
]
} |
the benzodiazepines midazolam , chlordiazepoxide , diazepam and n-desmethyldiazepam , the cyclopyrrolone zopiclone and the triazolopyridazine cl 218,872 had qualitatively similar stimulus effects regardless of the type of consequence ( food presentation or stimulus-shock termination ) that maintained responding . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
51,
59
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
66,
83
]
} |
the order of potency was : midazolam = diazepam greater than or equal to n-desmethyldiazepam greater than or equal to zopiclone greater than cl 218,872 greater than or equal to chlordiazepoxide . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
39,
47
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
75,
92
]
} |
after 3 h incubation in these solutions , the total cellular cl was reduced by the anions in the order br greater than no3 greater than i greater than scn greater than f greater than glucuronate . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
83,
89
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
136,
137
]
} |
after 3 h incubation in these solutions , the total cellular cl was reduced by the anions in the order br greater than no3 greater than i greater than scn greater than f greater than glucuronate . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
83,
89
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
168,
169
]
} |
the ability of foreign anions to inhibit a 3 min uptake of high specific activity , low concentration cl ( 6.5 mm ) suggests an apparent affinity series of no3 greater than cl = scn = br greater than i greater than f at the external site . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
23,
29
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
234,
235
]
} |
the ability of foreign anions to inhibit a 3 min uptake of high specific activity , low concentration cl ( 6.5 mm ) suggests an apparent affinity series of no3 greater than cl = scn = br greater than i greater than f at the external site . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
23,
29
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
215,
216
]
} |
the precise order of the affinity of these anions remains uncertain but the following sequence : no3 greater than cl = scn = br greater than i greater than f is considered to be the most likely . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
43,
49
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
188,
189
]
} |
the precise order of the affinity of these anions remains uncertain but the following sequence : no3 greater than cl = scn = br greater than i greater than f is considered to be the most likely . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
43,
49
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
156,
157
]
} |
especially , glycogen contents of the soleus and red-gastrocnemius significant increased ( p less than 0.05 ) , and liver glycogen content under the same condition increased significantly ( p less than 0.02 ) . | NA | {
"id": "C0017911",
"name": "glycogen",
"pos": [
13,
21
]
} | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
116,
130
]
} |
in light of the continued marketing of new alloys , bonding agents , and porcelains , further research is needed to determine the mechanism of action of bonding agents as well as the porcelain-bonding agent-alloy interaction of various commercial products . | NA | {
"id": "C0002154",
"name": "alloys",
"pos": [
43,
49
]
} | {
"id": "C0085402",
"name": "bonding",
"pos": [
193,
200
]
} |
insulin does not compete for igf-ii binding sites and proinsulin competes only weakly , suggesting that this is a type 2 igf receptor and not an insulin receptor . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
54,
64
]
} |
c3b receptor mediated clearance by the reticuloendothelial system ( res ) was tested in vivo using autologous c3b coated , technetium labelled erythrocytes in patients with rheumatoid arthritis ( ra ) and rheumatoid vasculitis . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
173,
193
]
} | {
"id": "C0240903",
"name": "rheumatoid vasculitis",
"pos": [
205,
226
]
} |
diminished c3b mediated erythrocyte clearance was found in all patients with rheumatoid vasculitis and some patients with active ra . | NA | {
"id": "C0240903",
"name": "rheumatoid",
"pos": [
77,
87
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
129,
131
]
} |
we assessed the frequency of retinal toxicity in patients receiving either chloroquine or hydroxychloroquine and factors which may predict patient susceptibility to toxicity . | NA | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
75,
86
]
} | {
"id": "C0020336",
"name": "hydroxychloroquine",
"pos": [
90,
108
]
} |
the percentage of patients withdrawn for adverse effects per patient-year was less with af when compared to injectable gold ( 14 vs 40 % ) . | NA | {
"id": "C0004320",
"name": "af",
"pos": [
88,
90
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
119,
123
]
} |
to evaluate the role of immunoglobulin ( ig ) allotypes in the pathogenesis of amyloidosis , 8 gm allotypes and the km 1 allotype were determined in the sera of patients with amyloid al ( n = 27 ) and amyloid aa ( n = 43 ) . | NA | {
"id": "C0021006",
"name": "immunoglobulin",
"pos": [
24,
38
]
} | {
"id": "C0021010",
"name": "gm allotypes",
"pos": [
95,
107
]
} |
to evaluate the role of immunoglobulin ( ig ) allotypes in the pathogenesis of amyloidosis , 8 gm allotypes and the km 1 allotype were determined in the sera of patients with amyloid al ( n = 27 ) and amyloid aa ( n = 43 ) . | NA | {
"id": "C0021006",
"name": "immunoglobulin",
"pos": [
24,
38
]
} | {
"id": "C0021016",
"name": "km",
"pos": [
116,
118
]
} |
l-proline uptake via the intestinal brush-border imino carrier was tested for inhibition by 41 compounds which included sugars , n-methylated , alpha- , beta- , gamma- and epsilon- amino and imino acids , and heterocyclic analogs of pyrrolidine , piperidine and pyridine . | NA | {
"id": "C0033382",
"name": "l-proline",
"pos": [
0,
9
]
} | {
"id": "C0020931",
"name": "imino acids",
"pos": [
191,
202
]
} |
a systematic study of the specificity of insertion of the transposable element is1 into small defined-sequence plasmids ( pbr322 and derivatives ) was conducted to determine the features of the dna sequence that influence target site selection . | NA | {
"id": "C0012868",
"name": "transposable element",
"pos": [
58,
78
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
194,
197
]
} |
although the latter enzyme contains 25 additional amino acid residues at the n terminus , both preparations yielded isomorphous tetragonal , bipyramidal crystals of the ternary complex of the enzyme with co2 and mg2+ . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
20,
26
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
177,
184
]
} |
based on the rates of amino acid substitution for 60 mammalian genes of 50 codons or more , it is shown that the rate of amino acid substitution of a protein is correlated with its amino acid composition . | NA | {
"id": "C0301714",
"name": "based",
"pos": [
0,
5
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
181,
191
]
} |
concentrations of hepatic reduced and oxidized glutathione ( gsh and gssg ) tended to increase after cobalt , but changes were not statistically significant . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
61,
64
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
69,
73
]
} |
characteristic fracture patterns for the low energy group consisted of the drill hole , unicortical , oblique , spiral , butterfly , and comminuted . | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
15,
23
]
} | {
"id": "C0476171",
"name": "comminuted",
"pos": [
137,
147
]
} |
most femur fractures were successfully treated by nonoperative means , and most of the hip fractures were treated operatively . | NA | {
"id": "C0015802",
"name": "femur fractures",
"pos": [
5,
20
]
} | {
"id": "C0019557",
"name": "of",
"pos": [
80,
82
]
} |
contrary to the popular belief that emesis may be contraindicated in children less than twelve months of age , we believe that emesis can be safely induced in the home setting in these young children . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
69,
77
]
} | {
"id": "C0728836",
"name": "young children",
"pos": [
185,
199
]
} |
our indications for hbo treatment were : coma , pathological neurological findings or loss of consciousness during co exposure irrespective of normal clinical findings on admission . | NA | {
"id": "C0009421",
"name": "coma",
"pos": [
41,
45
]
} | {
"id": "C0041657",
"name": "loss of",
"pos": [
86,
93
]
} |
referral to a hbo center should be considered when : -- the patient is comatose -- there are abnormal clinical findings -- patients have been unconsciousness during exposure , irrespective of whether they are conscious on admission and have normal clinical status . | NA | {
"id": "C0009421",
"name": "comatose",
"pos": [
71,
79
]
} | {
"id": "C0041657",
"name": "unconsciousness",
"pos": [
142,
157
]
} |
34 patients aged between 2 and 80 years were treated with digoxin specific antibody ( fab ) fragments for severe digitalis poisoning . | NA | {
"id": "C0700607",
"name": "digoxin specific",
"pos": [
58,
74
]
} | {
"id": "C0021031",
"name": "fab",
"pos": [
86,
89
]
} |
the following criteria were considered to be indications for use of fab fragments : the appearance of life-threatening arrhythmias such as high-grade atrioventricular conduction disorders ( grade 2 and 3 a-v block ) , multifocal ectopic beats , ventricular tachycardia , and relapsing ventricular fibrillation . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
119,
130
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
285,
309
]
} |
cholecystokinin ( cck-op ) and caerulein elicited motor responses of the gallbladder in a dose-related manner without antroduodenal stimulation . | NA | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
0,
15
]
} | {
"id": "C0037167",
"name": "cck-op",
"pos": [
18,
24
]
} |
after four daily , treatments with procaine penicillin g and penethamate hydriodide , infections were eliminated from 56.5 % and 68.8 % , respectively , of quarters infected with penicillin g-sensitive staphylococci , and from 14.3 % and 7.7 % , respectively , of quarters infected with penicillin g-resistant staphyloco... | NA | {
"id": "C0030830",
"name": "procaine penicillin g",
"pos": [
35,
56
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
287,
299
]
} |
diminishing complement-independent neutralizing antibody titers occurred after the second dose and were associated with loss or reduction of detectable antibody to gd . | NA | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
35,
56
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
152,
160
]
} |
the e1b 58,000- and 19,000-molecular-weight proteins ( 58k and 19k proteins ; 496r and 176r ) as well as the e2a 72k dna-binding protein were relatively stable over the 4-h chase period ; | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
44,
52
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
117,
136
]
} |
the failure of bethanechol chloride to induce voiding in patients with neurogenic bladder , despite a positive bethanechol test , is being reported more frequently . | NA | {
"id": "C0106169",
"name": "bethanechol chloride",
"pos": [
15,
35
]
} | {
"id": "C0053526",
"name": "bethanechol",
"pos": [
111,
122
]
} |
hyaluronic acid and dermatan sulfate were the major glycosaminoglycans of the normal epithelium/submucosa while heparan sulfate and dermatan sulfate were predominant in normal bladder muscle . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
52,
70
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
112,
127
]
} |
in the classic subclavian steal syndrome , vertebrobasilar insufficiency is caused by reverse flow in the vertebral artery ipsilateral to a subclavian stenosis or occlusion . | NA | {
"id": "C0038531",
"name": "subclavian steal syndrome",
"pos": [
15,
40
]
} | {
"id": "C0042568",
"name": "vertebrobasilar insufficiency",
"pos": [
43,
72
]
} |
sem observations coupled with the findings of conventional and electron microscopy suggest that cells composing ans are of mesenchymal origin having characters of epithelioid cells , reticular cells and/or fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
96,
101
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
206,
217
]
} |
he was completely free from arrhythmia except for the ventricular ectopic beats which developed around 9:00 p.m. and the ventricular flutter following an r-on-t type ventricular ectopic beat which resulted in death during the night . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
28,
38
]
} | {
"id": "C0152173",
"name": "ventricular flutter",
"pos": [
121,
140
]
} |
in particular , recent advance of chemotherapy makes possible of curing of advanced lymphoma patients , especially hodgkin 's disease . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
84,
92
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
115,
133
]
} |
all small cell carcinomas and carcinoid tumors were positively stained by leu-7 , and 22 of 41 differentiated adenocarcinomas were also positively stained , especially well-differentiated clara cell-type adenocarcinoma , ( 11/14 cases ) . | NA | {
"id": "C0007095",
"name": "carcinoid tumors",
"pos": [
30,
46
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
204,
218
]
} |
however , only one of 41 differentiated adenocarcinomas and no small cell carcinomas nor carcinoid tumors were stained by okt-9 . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
40,
55
]
} | {
"id": "C0007095",
"name": "carcinoid tumors",
"pos": [
89,
105
]
} |
the amino sugars glucosamine or mannosamine in the combination caused a synergistic cytotoxic effect , while the other carbohydrates ( n-acetylmannosamine , n-acetylglucosamine , or mannose ) had little effect . | NA | {
"id": "C0002531",
"name": "amino sugars",
"pos": [
4,
16
]
} | {
"id": "C0007004",
"name": "carbohydrates",
"pos": [
119,
132
]
} |
the amino sugars glucosamine or mannosamine in the combination caused a synergistic cytotoxic effect , while the other carbohydrates ( n-acetylmannosamine , n-acetylglucosamine , or mannose ) had little effect . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
17,
28
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
157,
176
]
} |
an unsaturated fatty acid ( oleate ) caused an increase in lipid fluidity of the surface membrane in molt-4 lymphoid cells , which possess higher lipid fluidity in combination with mannosamine , while saturated fatty acids had no effect on the fluidity properties of the membrane lipids ( even in the presence of mannosa... | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
59,
64
]
} | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
271,
286
]
} |
binding affinities of denopamine and some beta-agonists for rat heart membranes ( kih ) , which contain predominantly the beta 1-subtype , were in the order of isoproterenol ( iso , 14.1 nm ) greater than prenalterol ( 158 ) greater than norepinephrine ( nor , 227 ) greater than or equal to epinephrine ( epi , 248 ) gr... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
238,
252
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
292,
303
]
} |
in the presence of guanine nucleotide ( gtp ) , the denopamine radioligand competition curve showed a rightward shift , and its hill coefficient increased like other agonists , although the degree of the shift was less than that observed with full agonists such as iso . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
19,
37
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
40,
43
]
} |
moreover , dibutyryl cyclic amp at concentrations above 10 ( -4 ) m inhibited potassium release in a dose-dependent manner and cyclic amp caused an enhancement of the microsomal na+ , k+-atpase activity . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
11,
31
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
127,
137
]
} |
fish protein did not appear to produce a significantly different preneoplastic response when compared to casein as a protein source . | NA | {
"id": "C0598294",
"name": "fish protein",
"pos": [
0,
12
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
117,
124
]
} |
this study provides evidence that fish oils , rich in omega 3 fatty acids , may have potential as inhibitory agents in cancer development . | NA | {
"id": "C0016157",
"name": "fish oils",
"pos": [
34,
43
]
} | {
"id": "C0015689",
"name": "omega 3 fatty acids",
"pos": [
54,
73
]
} |
the present paper describes 3 out of a total of 9 siblings , aged 9 , 17 , and 18 , with the following symptoms : gargoyle-like facial features , clouding of the cornea in both eyes , dysostosis multiplex , slightly impaired intelligence , hepatosplenomegaly , umbilical hernia , and increased secretion of mucopolysacch... | NA | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
307,
326
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
369,
384
]
} |
in 25 patients , cyclosporin eye drops ( 2 % in castor oil ) were given in combination with low-dose dexamethasone eye drops ( 0.1 % ) . | NA | {
"id": "C0015399",
"name": "eye drops",
"pos": [
29,
38
]
} | {
"id": "C0991568",
"name": "drops",
"pos": [
119,
124
]
} |
the decrease between 1968 and 1978 ( period of validity of the 8th revision of the icd ) in the three countries was mostly due to the diseases of the circulatory system : in japan , mostly to cerebrovascular diseases , in the usa , to ischaemic heart diseases , and in the frg , to other forms of heart diseases . | NA | {
"id": "C0151744",
"name": "ischaemic heart diseases",
"pos": [
235,
259
]
} | {
"id": "C0018799",
"name": "of heart diseases",
"pos": [
294,
311
]
} |
the function of the sympathoadrenal system ( sas ) measured with respect to the content of epinephrine and norepinephrine in blood and urine as well as dopamine and dopa in urine of mountaineers and athletes nontrained to high altitudes was examined . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
91,
102
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
107,
121
]
} |
the percentages of recovery of pbmc and of cells expressing the above markers were lowest among pbmc isolated with a ficoll-hypaque mixture of density 1.077 and highest among pbmc obtained by using a solution of percoll of density 1.077 . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
43,
48
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
175,
179
]
} |
the reduced levels of pbmc with detectable markers appeared to result from an effect of either ficoll or hypaque on the lymphocytes rather than from loss of lymphocyte subpopulations since higher proportions of cells bearing t4 , t8 , t11 and ia were found when pbmc were isolated with a solution of percoll which yielde... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
211,
216
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
338,
342
]
} |
altered marker expression by cells obtained with ficoll-hypaque was not seen with similarly prepared human pbmc . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
29,
34
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
107,
111
]
} |
according their differential reactivity , the 15 benzodiazepines can be classified into three groups : good reactivity similar to diazepam ( potassium clorazepate , prazepam , estazolam , medazepam , flunitrazepam , nitrazepam ) ; | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
49,
64
]
} | {
"id": "C0009033",
"name": "potassium clorazepate",
"pos": [
141,
162
]
} |
according their differential reactivity , the 15 benzodiazepines can be classified into three groups : good reactivity similar to diazepam ( potassium clorazepate , prazepam , estazolam , medazepam , flunitrazepam , nitrazepam ) ; | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
49,
64
]
} | {
"id": "C0025051",
"name": "medazepam",
"pos": [
188,
197
]
} |
the rates of 125i-fibronectin clearance were increased in starvation and hemorrhagic shock ( t1/2 = 233.0 +/- 13.0 min , controls ; 174.6 +/- 10.7 min , starvation ; 167.4 +/- 13.6 min , hemorrhage ) . | NA | {
"id": "C0036982",
"name": "hemorrhagic shock",
"pos": [
73,
90
]
} | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
187,
197
]
} |
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