text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
early diagnosis of skull base lesions is enhanced by a careful neuro-otologic history and physical examination on all patients with complaints of pain , headache , or cranial nerve dysfunction , either motor or sensory . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
146,
150
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
153,
161
]
} |
scatchard plots of the binding data were curvilinear and revealed that fibroblasts contained about 7,000 receptor sites per cell . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
71,
82
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
124,
128
]
} |
each unidirectional sulfate flux was influenced by the sulfate concentration in the solution on the opposite side in a pattern consistent with the presence of an anion exchange mechanism . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
20,
27
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
162,
167
]
} |
these experiments suggest that 1 ) mild lvh ( 25 % increase in lv mass ) can significantly decrease coronary dilator reserve and 2 ) within the time frame examined ( 6 wk to 6 mo ) , the duration of hypertension and lvh does not increase the coronary vascular abnormalities associated with cardiac enlargement . | NA | {
"id": "C0149721",
"name": "lvh",
"pos": [
40,
43
]
} | {
"id": "C0018800",
"name": "cardiac enlargement",
"pos": [
290,
309
]
} |
histologically , the lesion may be mistaken for benign and malignant neoplasms such as osteosarcoma or parosteal osteosarcoma or osteochondromas . | NA | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
87,
99
]
} | {
"id": "C0206642",
"name": "parosteal osteosarcoma",
"pos": [
103,
125
]
} |
we previously showed that basal and pentagastrin-stimulated gastric acid secretion , gastrin in serum and gastrin in antral mucosa were significantly greater in patients with roux-y hepaticojejunostomy than in those with choledochoduodenostomy . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
36,
48
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
106,
113
]
} |
an operative approach to treatment of proximal subclavian occlusive lesions was used in 11 patients with claudication of the arm , vertebrobasilar insufficiency or subclavian steal syndrome . | NA | {
"id": "C0042568",
"name": "vertebrobasilar insufficiency",
"pos": [
131,
160
]
} | {
"id": "C0038531",
"name": "subclavian steal syndrome",
"pos": [
164,
189
]
} |
the artificial pancreas produced a stable glycemic baseline before surgery , prevented hypoglycemia during palpation of the pancreas and manipulation of the tumor , and indirectly amplified small decreases in the blood sugar level with large increases in the rate of dextrose infusion . | NA | {
"id": "C0005802",
"name": "in",
"pos": [
56,
58
]
} | {
"id": "C0017725",
"name": "dextrose",
"pos": [
267,
275
]
} |
kartagener 's syndrome , originally described as situs inversus , bronchiectasis , and sinusitis , has recently been demonstrated to be the result of a genetic defect manifest in structural and functional abnormalities of cilia . | NA | {
"id": "C0022521",
"name": "kartagener 's syndrome",
"pos": [
0,
22
]
} | {
"id": "C0006267",
"name": "bronchiectasis",
"pos": [
66,
80
]
} |
to clarify the pathophysiological role of homocarnosine in the cerebrospinal fluid ( csf ) in children , homocarnosine levels in csf were determined in patients with epilepsy ( 32 cases ) , febrile convulsion ( 5 cases ) and meningitis ( 42 cases ) with a high speed amino acid autoanalyzer ( hitachi co. ) . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
166,
174
]
} | {
"id": "C0009952",
"name": "febrile convulsion",
"pos": [
190,
208
]
} |
high homocarnosine levels in csf of children with uncontrolled epilepsy or febrile convulsion may indicate the reduced turnover rate from homocarnosine to gaba . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
63,
71
]
} | {
"id": "C0009952",
"name": "febrile convulsion",
"pos": [
75,
93
]
} |
a comparison of alfentanil and fentanyl in short operations with special reference to their duration of action and postoperative respiratory depression . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
16,
26
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
31,
39
]
} |
ninety women undergoing short gynaecological operations were included in a double-blind comparison of fentanyl and alfentanil , a structurally related and very short-acting narcotic analgesic . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
102,
110
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
115,
125
]
} |
anaesthesia was induced by methohexitone followed by a double-blind injection of either alfentanil ( 0.5 mg/ml ) or fentanyl ( 0.05 mg/ml ) . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
88,
98
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
116,
124
]
} |
for the same duration of anaesthesia , respiratory depression had to be reversed in 11 % of the alfentanil and 51 % of the fentanyl group and the time of awakening was significantly shorter in the alfentanil group . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
123,
131
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
197,
207
]
} |
quantification of cell death in human fibroblasts by measuring the loss of [ 14c ] thymidine from prelabeled cell monolayers . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
38,
49
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
109,
113
]
} |
multiple cardiac arrhythmias consisting of multifocal , or unifocal , multiform ventricular ectopic beats , bidirectional tachycardia , complete heart block , accelerated junctional rhythm with exit block , nonparoxysmal junctional tachycardia , atrial fibrillation , atrial tachycardia with block , and multifocal tachy... | NA | {
"id": "C0003811",
"name": "cardiac arrhythmias",
"pos": [
9,
28
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
246,
265
]
} |
aflatoxin m1 appeared in milk 3 to 6 hours after aflatoxin consumption began , and persisted for 72 hours or longer after the last dose of aflatoxin was given . | NA | {
"id": "C0085181",
"name": "aflatoxin m1",
"pos": [
0,
12
]
} | {
"id": "C0001734",
"name": "aflatoxin",
"pos": [
139,
148
]
} |
we analyzed the records of 129 consecutive patients with hemoptysis to evaluate whether or not early ( during hemoptysis or during the 48 h after hemoptysis stopped ) fiberoptic bronchoscopy ( fb ) more frequently localized and/or diagnosed the source of bleeding and influenced clinical outcome than delayed fb ( 48 h o... | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
255,
263
]
} | {
"id": "C0019079",
"name": "hemoptysis",
"pos": [
333,
343
]
} |
to determine whether disodium cromoglycate ( cromolyn ) inhibits the bronchoconstriction produced by inhalation of sulfur dioxide ( so2 ) in people with asthma , we undertook a study of 6 asthmatic subjects . | NA | {
"id": "C0012694",
"name": "disodium cromoglycate",
"pos": [
21,
42
]
} | {
"id": "C0086073",
"name": "cromolyn",
"pos": [
45,
53
]
} |
the purpose of his double-blind , randomized trial was to compare ear drops containing either trimethoprim and polymyxin b ( tp ) or trimethoprim , sulphacetamide and polymyxin b ( tsp ) from the points of view of effectiveness and safety . | NA | {
"id": "C0032535",
"name": "polymyxin b",
"pos": [
111,
122
]
} | {
"id": "C0032539",
"name": "polymyxin",
"pos": [
167,
176
]
} |
the highest major disagreement rates for bacteria were with staphylococcus epidermidis , enterococci , gram-positive bacilli , and providencia species , and those for antibiotics were with ampicillin and penicillin g . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
189,
199
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
204,
216
]
} |
when the drugs were administered at various time intervals before infection , ceftriaxone was superior to cefotaxime , cefmenoxime , and moxalactam . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
78,
89
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
106,
116
]
} |
when the drugs were administered at various time intervals before infection , ceftriaxone was superior to cefotaxime , cefmenoxime , and moxalactam . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
106,
116
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
119,
130
]
} |
in a murine meningitis model induced by klebsiella pneumoniae or streptococcus pneumoniae , ceftriaxone was more active than ampicillin or cefotaxime . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
92,
103
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
139,
149
]
} |
ceftriaxone was more active than ampicillin , cefotaxime , piperacillin , cefamandole , or carbenicillin in a pneumococcal , pneumonia model in mice . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
0,
11
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
46,
56
]
} |
ceftriaxone was more active than ampicillin , cefotaxime , piperacillin , cefamandole , or carbenicillin in a pneumococcal , pneumonia model in mice . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
33,
43
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
59,
71
]
} |
it was also resistant to hydrolysis by most cephalosporinases , but was susceptible to hydrolysis by a proteus vulgaris beta-lactamase . | NA | {
"id": "C0728805",
"name": "cephalosporinases",
"pos": [
44,
61
]
} | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
120,
134
]
} |
influence of study design in assessing food effects on absorption of erythromycin base and erythromycin stearate . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
69,
81
]
} | {
"id": "C0059566",
"name": "erythromycin stearate",
"pos": [
91,
112
]
} |
we performed a series of six single-dose and multiple-dose studies to evaluate the effect of food on the absorption of erythromycin base and erythromycin stearate . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
119,
131
]
} | {
"id": "C0059566",
"name": "erythromycin",
"pos": [
141,
153
]
} |
susceptibility of pneumococci to 14 beta-lactam agents : comparison of strains resistant , intermediate-resistant , and susceptible to penicillin . | NA | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
36,
47
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
135,
145
]
} |
minimal inhibitory concentrations of benzyl penicillin , oxacillin , cephalothin , cefamandole , cefoxitin , moxalactam ( ly127935 ) , cefotaxime ( hr756 ) , piperacillin , pirbenicillin , n-formimidoyl thienamycin ( mk0787 ) , cefoperazone ( t1551 ) , mezlocillin , azlocillin , and mecillinam were determined . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
83,
94
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
228,
240
]
} |
the relative differences in susceptibility to penicillin of each group of pneumococci tested were similar for each of the beta-lactam agents tested . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
46,
56
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
122,
133
]
} |
most were susceptible to achievable levels of cefamandole , erythromycin , and metronidazole , and more than 10 % were resistant to achievable levels of cephalexin and cephradine . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
153,
163
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
168,
178
]
} |
isolate identification revealed that mar gram-positive cocci ( staphylococcus ) and mar gram-negative , nonfermentative rods ( pseudomonas , alcaligenes , moraxella-like group m , and acinetobacter ) were more common in drinking waters than in untreated source waters . | NA | {
"id": "C0599638",
"name": "drinking waters",
"pos": [
220,
235
]
} | {
"id": "C0043047",
"name": "waters",
"pos": [
261,
267
]
} |
the frequent occurrence of an infraorbital fold in patients with atopic dermatitis may be caused by the fact that the eyelid is a site of predilection for this dermatitis . | NA | {
"id": "C0011615",
"name": "atopic dermatitis",
"pos": [
65,
82
]
} | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
160,
170
]
} |
a 28-year-old man with slight blood eosinophilia had multiple dermal lesions of angiolymphoid hyperplasia with eosinophilia in the right knee region . | NA | {
"id": "C0002989",
"name": "dermal",
"pos": [
62,
68
]
} | {
"id": "C0014457",
"name": "eosinophilia",
"pos": [
111,
123
]
} |
the bone marrow and blood monocytes are precursor cells to the macrophage-histiocyte , the langerhans cell , the indeterminate cell , the interdigitating cell , and the dendritic cell in the thymus , lymph node , and skin . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
40,
55
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
187,
190
]
} |
follow-up liver chemistries and amino acids which may be useful as an indicator of hepatic function suggest that although the distal shunt group had a better amino acid pattern before operation , branched-chain amino acids tend to become lower in the distal group while remaining the same in the central group . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
32,
43
]
} | {
"id": "C0002521",
"name": "branched-chain",
"pos": [
196,
210
]
} |
since the content of these enzymes and their isoenzymes has not been established for the esophagus , an experiment was conducted to evaluate and compare the enzymes in postmortem specimens from humans and fresh canine specimens . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
45,
55
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
157,
164
]
} |
six patients with lung abscesses , three with necrotizing pneumonia , and one with pneumonia and empyema received clindamycin . | NA | {
"id": "C0264515",
"name": "necrotizing pneumonia",
"pos": [
46,
67
]
} | {
"id": "C0032285",
"name": "pneumonia",
"pos": [
83,
92
]
} |
in a one- to 15-year follow-up of 124 patients with a history of subacute thyroiditis ( sat ) without and with spontaneously resolving hyperthyroidism ( srh ) ( sat and sat-srh , respectively ) , only three cases of thyroid disease probably unrelated to the original episode of thyroiditis were found . | NA | {
"id": "C0020550",
"name": "srh",
"pos": [
153,
156
]
} | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
216,
231
]
} |
in a one- to 15-year follow-up of 124 patients with a history of subacute thyroiditis ( sat ) without and with spontaneously resolving hyperthyroidism ( srh ) ( sat and sat-srh , respectively ) , only three cases of thyroid disease probably unrelated to the original episode of thyroiditis were found . | NA | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
216,
231
]
} | {
"id": "C0040147",
"name": "thyroiditis",
"pos": [
278,
289
]
} |
however , of the 54 patients with a history of lymphocytic thyroiditis ( lt ) with srh ( lt-srh ) , 26 patients were found to have thyroid disease ( three with hypothyroidism and 23 with goiters ) . | NA | {
"id": "C0020550",
"name": "srh",
"pos": [
83,
86
]
} | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
131,
146
]
} |
however , of the 54 patients with a history of lymphocytic thyroiditis ( lt ) with srh ( lt-srh ) , 26 patients were found to have thyroid disease ( three with hypothyroidism and 23 with goiters ) . | NA | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
131,
146
]
} | {
"id": "C0020676",
"name": "hypothyroidism",
"pos": [
160,
174
]
} |
however , of the 54 patients with a history of lymphocytic thyroiditis ( lt ) with srh ( lt-srh ) , 26 patients were found to have thyroid disease ( three with hypothyroidism and 23 with goiters ) . | NA | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
131,
146
]
} | {
"id": "C0018021",
"name": "goiters",
"pos": [
187,
194
]
} |
these findings demonstrate that sat and sat-srh are transient thyroid disease rarely leading to permanent thyroid disease , although some loss of thyroid reserve may occur . | NA | {
"id": "C0020550",
"name": "srh",
"pos": [
44,
47
]
} | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
106,
121
]
} |
complete oxidation of acetate to co2 was shown by stoichiometric measurements with strain 2ac9 in batch cultures using sulfate , sulfite or thiosulfate as electron acceptors . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
119,
126
]
} | {
"id": "C0039950",
"name": "thiosulfate",
"pos": [
140,
151
]
} |
pasteurella strains were very susceptible to chloramphenicol ( 82.3 % ) , tetracycline ( 68 % ) , penicillin ( 47 % ) , and ampicillin and resistant to oxacillin , streptomycin and kanamycin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
98,
108
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
152,
161
]
} |
immunosorbents were obtained by coupling the antibody ( igg ) fraction isolated from anti-bymv and anti-pea leaf protein antisera with cnbr-activated 1 % agarose beads . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
45,
53
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
121,
129
]
} |
the humoral immune response to t-dependent antigens ( srbc , dnp5bsa , dnp50bsa , dnp-klh ) and t-independent antigens ( siii , levan , dnp-siii , dnp-levan ) was studied by hemolytic plaque assay in mice depleted of c3 by cobra venom treatment . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
43,
51
]
} | {
"id": "C0003340",
"name": "t-independent antigens",
"pos": [
96,
118
]
} |
most of the fractures are pathologic in osteoporotic bones and most occur without known trauma or are caused by trivial injury . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
12,
21
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
88,
94
]
} |
clinical examples of altered cell and organ function with ischemia and shock are numerous and play a critical role in the development of multiple systems failure . | NA | {
"id": "C0036974",
"name": "shock",
"pos": [
71,
76
]
} | {
"id": "C0026766",
"name": "multiple",
"pos": [
137,
145
]
} |
tumor size , relative distance of the tumor from the nipple , and tumor histologic type were investigated and compared with nipple-areolar involvement . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
0,
5
]
} | {
"id": "C0027652",
"name": "tumor histologic type",
"pos": [
66,
87
]
} |
factors responsible for different quantitative effect of phenobarbital ( pb ) pretreatment ( sodium phenobarbital , 50 mg kg-1 day-1 for 3 days ) on benzene metabolism to phenol in vivo and in vitro were studied in male wistar rats . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
57,
70
]
} | {
"id": "C0282303",
"name": "sodium phenobarbital",
"pos": [
93,
113
]
} |
the elimination of radioactive metabolites of orally administered benzene-14c , 3 mmoles kg-1 , in urine was markedly inhibited by intraperitoneal administration of phenol ( 1.2 mmol kg-1 ) , but not by pyrocatechol , resorcinol or hydroquinol ( 0.6 mmole kg-1 , respectively ) suggesting that phenol might inhibit benze... | NA | {
"id": "C0035197",
"name": "resorcinol",
"pos": [
218,
228
]
} | {
"id": "C0031428",
"name": "phenol",
"pos": [
294,
300
]
} |
comparative studies on the elimination and biodistribution of ( 14c ) chlorferron and its parent compound ( 14c ) coumaphos in male rats indicated rapid metabolism and faster elimination of chlorferron and its metabolites from the body than that of the parent compound . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
153,
163
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
175,
186
]
} |
in addition to the cardinal signs of the syndrome this patient presented some abnormalities which have not been previously described such as macroglossia , multiple dental anomalies , basilar impression and platybasia , megacolon , hypertrophy of clitoris and anal ectopy . | NA | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
78,
91
]
} | {
"id": "C0000772",
"name": "multiple",
"pos": [
156,
164
]
} |
in four volunteers , dipivefrin plus echothiophate produced a significantly greater reduction in intraocular pressure than epinephrine plus echothiophate . | NA | {
"id": "C0058415",
"name": "dipivefrin",
"pos": [
21,
31
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
123,
134
]
} |
as a group the eight eyes treated with dipivefrin plus echothiophate had significantly lower iops than the eyes treated with epinephrine plus echothiophate during the second week of therapy . | NA | {
"id": "C0058415",
"name": "dipivefrin",
"pos": [
39,
49
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
125,
136
]
} |
the c variant differs from the common b variant in having one more amide residue ( substitution or gln for glu ) . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
99,
102
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
107,
110
]
} |
examination of the glycosaminoglycan species present in the cultures showed the presence of hyaluronic acid , dermatan sulfate , chondroitin-4-sulfate , heparin and heparan sulfate-c , the first two compounds being secreted into the culture medium . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
19,
36
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
153,
160
]
} |
examination of the glycosaminoglycan species present in the cultures showed the presence of hyaluronic acid , dermatan sulfate , chondroitin-4-sulfate , heparin and heparan sulfate-c , the first two compounds being secreted into the culture medium . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
19,
36
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
165,
180
]
} |
mg/+ was more effective , however , in increasing the orthophosphatase activity of the enzyme and its stimulating effects in this case were greater in carbonate-bicarbonate buffer than in glycine-naoh buffer . | NA | {
"id": "C0007026",
"name": "carbonate",
"pos": [
151,
160
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
161,
172
]
} |
these agents were : isoproterenol ( 10 ( -6 ) m ) , noradrenaline , adrenaline ( 10 ( -5 ) m each ) , glucagon , histamine ( 10 ( -3 ) m each ) , theophylline and caffeine ( 5.10 ( -2 ) m each ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
52,
65
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
68,
78
]
} |
there are indications of influences during pregnancy such as low supply of thiamine in the 1st trimester and with vitamin a and vitamin b6 in the last trimester on the birth weights . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
43,
52
]
} | {
"id": "C0032979",
"name": "1st trimester",
"pos": [
91,
104
]
} |
beta-endorphin : replacement of glutamic acid in position 8 by glutamine increases analgesic potency and opiate receptor-binding activity . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
32,
45
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
63,
72
]
} |
hemoglobin solubility as a function of fractional oxygen saturation for hemoglobins in polyethylene glycol : a sickle hemoglobin model . | NA | {
"id": "C0019016",
"name": "hemoglobin",
"pos": [
0,
10
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
72,
83
]
} |
when the 3t3 fibroblasts were incubated with cationised low density lipoprotein ( ldl ) the amount of esterified cholesterol which accumulated in the cells was greatly increased . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
150,
155
]
} |
peptides inhibiting angiotensin ii , such as sar1 , ala8 angiotensin ii , block the peripheral effects of angiotensin on vascular renal and adrenal receptors . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
20,
34
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
106,
117
]
} |
[ desmoid fibroma of bone . an histoenzymological and ultrastructural study of the mandible in one case ( author 's transl ) ] . | NA | {
"id": "C0079218",
"name": "desmoid",
"pos": [
2,
9
]
} | {
"id": "C0016045",
"name": "bone",
"pos": [
21,
25
]
} |
on electron microscopy , a part from a few primitive mesenchymal cells , abnormal fibroblasts represented the principal cellular component . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
82,
93
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
120,
128
]
} |
the antimicrobials submitted to the test of susceptibility were : ampicillin , amikacin , carbenicillin , cephalothin , cefoxitin , chloramphenicol , gentamicin , kanamycin , neomycin and sulfamethoxazole-trimethoprim . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
79,
87
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
163,
172
]
} |
glucosamine - 6p , acetylglucosamine and acetylglucosamine and have shown a considerably lower inhibition in the uptake of these labeled precursors . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
0,
11
]
} | {
"id": "C0001056",
"name": "acetylglucosamine",
"pos": [
41,
58
]
} |
the uptake of h+ induced by sulphate or thiosulphate is abolished by nem and butylmalonate in freshly isolated rlm , whereas it is inhibited only by butylmalonate in sulphite-pretreated mitochondria . | NA | {
"id": "C0038720",
"name": "sulphate",
"pos": [
28,
36
]
} | {
"id": "C0039950",
"name": "thiosulphate",
"pos": [
40,
52
]
} |
in the pretreated animals the endogenous mrna directed incorporation of aminoacids into the microsomal protein as measured in vitro , is maintained at nearly the normal level 30 min after ccl4 poisoning , but it is strongly depressed 60 min after poisoning . | NA | {
"id": "C0392622",
"name": "ccl4",
"pos": [
188,
192
]
} | {
"id": "C0032343",
"name": "poisoning",
"pos": [
247,
256
]
} |
[ normal pressure hydrocephalus ( nph ) following subarachnoid hemorrhage ( sah ) -clinical consideration of ct and development of hydrocephalus after sah ( author 's transl ) ] . | NA | {
"id": "C0020258",
"name": "normal pressure hydrocephalus",
"pos": [
2,
31
]
} | {
"id": "C0020255",
"name": "hydrocephalus",
"pos": [
131,
144
]
} |
ct scans were used to evaluate the development of the hydrocephalus , periventricular hypodensity ( pvh ) and the degree of the brain damage on 33 patients with the normal pressure hydrocephalus ( nph ) , following the subarachnoid hemorrhage ( sah ) , and the following conclusion can be drawn from our study . | NA | {
"id": "C0020255",
"name": "hydrocephalus",
"pos": [
54,
67
]
} | {
"id": "C0020258",
"name": "nph",
"pos": [
197,
200
]
} |
rhabdomyolysis , myoglobinuria and hyperpyrexia caused by suxamethonium in a child with increased serum creatine kinase concentrations . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
0,
14
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
17,
30
]
} |
the maximum hb aic values were significantly higher in the second trimester ( p less than 0.001 ) in these pregnancies than in the other diabetic pregnancies . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
59,
75
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
146,
157
]
} |
late third trimester unconjugated serum oestriol levels in normal and hypertensive pregnancy : relation to birth weight . | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
5,
20
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
83,
92
]
} |
the regeneration pathway could be represented in terms of two simple reactions , rnase a ( -sh ) + gssg in equilibrium or formed from rnase a ( -ssg ) + gsh and rnase a ( -sh-ssg ) in equilibrium rnase a ( greater than s2 ) + gsh , which produced 24 monomeric intermediates ( not counting the fully reduced and the nativ... | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
99,
103
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
226,
229
]
} |
carbon-13 nuclear magnetic resonance study of protonation of methotrexate and aminopterin bound to dihydrofolate reductase . | NA | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
61,
73
]
} | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
78,
89
]
} |
the same result was obtained for the binary complex of aminopterin with the reductase and for either methotrexate or aminopterin in ternary complex with reductase and nadph4 . | NA | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
101,
113
]
} | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
117,
128
]
} |
a highly conserved region ( underlined ) readily identifies the molecule as a structural homologue of other 5s rrnas , as do potential base-paired regions which are characteristic of all known ( prokaryotic , chloroplast , eukaryotic cytosol ) 5s rrna sequences . | NA | {
"id": "C0035701",
"name": "rrnas",
"pos": [
111,
116
]
} | {
"id": "C0035707",
"name": "5s rrna",
"pos": [
244,
251
]
} |
however , when assessed in terms of those structural features which distinguish prokaryotic from eukaryotic 5s rrnas , wheat mitochondrial 5s rrna can not be classified readily as one or the other but instead displays characteristics of both types . | NA | {
"id": "C0035701",
"name": "rrnas",
"pos": [
111,
116
]
} | {
"id": "C0035707",
"name": "5s rrna",
"pos": [
139,
146
]
} |
naturally occurring differences in the nucleotide sequences of 5.8s ribosomal ribonucleic acids ( rrnas ) from a variety of organisms have been used to study the role of specific nucleotides in the secondary structure and intermolecular interactions of this rna . | NA | {
"id": "C0035701",
"name": "ribosomal",
"pos": [
68,
77
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
258,
261
]
} |
the results support secondary structure models for free 5.8s rrna in which the termini interact to various degrees and 5.8s -- 28s rrna junctions in which both termini of the 5.8s molecule interact with the cognate high molecular weight rna component . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
61,
65
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
237,
240
]
} |
the results indicate that the enzyme forms a stable complex over a wide range of enzyme and lipid concentrations . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
30,
36
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
52,
59
]
} |
from the equivalent `` '' molecular weight '' '' and from the lipid to enzyme molar ratio ( n ) of the micelle -- enzyme complex , it can be calculated that complexes containing saturated hydrocarbon chain lipids generally consist of two enzyme molecules and half of the number of lipid monomers present in free micelles... | NA | {
"id": "C0026741",
"name": "-- enzyme compl",
"pos": [
111,
126
]
} | {
"id": "C0014442",
"name": "enzy",
"pos": [
71,
75
]
} |
the other cations , mg2+ , mn2+ , zn2+ , and cu2+ , could not restore the binding activity of the lectin to the same degree as ca2+ or a combination of all ions . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
10,
17
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
156,
160
]
} |
on the basis of amino acid analysis , secretory protein i contains about 30 % acidic amino acid residues , contributing to an isoelectric point of 4.5 , and has a minimum molecular weight of about 70 000 . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
16,
26
]
} | {
"id": "C0815040",
"name": "acidic amino acid",
"pos": [
78,
95
]
} |
changes in messenger ribonucleic acid ( mrna ) populations during embryogenesis of cottonseed have been followed by cataloging ( a ) extant proteins , ( b ) proteins synthesized in vivo , and ( c ) proteins synthesized in vitro from extracted rna , all at specific stages of embryogenesis . | NA | {
"id": "C0035696",
"name": "messenger ribonucleic acid",
"pos": [
11,
37
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
243,
246
]
} |
radiochemical n-terminal sequencing of the synthesized nadh dehydrogenase showed that the product was a mixture of three different species , with n-formylmethionine , methionine , or threonine at the n terminus . | NA | {
"id": "C0027228",
"name": "n-formylmethionine",
"pos": [
146,
164
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
167,
177
]
} |
laser photochemically induced dynamic nuclear polarization proton nuclear magnetic resonance studies on three homologous calcium binding proteins : cardiac troponin-c , skeletal troponin-c , and calmodulin . | NA | {
"id": "C0006732",
"name": "calcium binding proteins",
"pos": [
121,
145
]
} | {
"id": "C0077400",
"name": "troponin-c",
"pos": [
178,
188
]
} |
anions stimulate voltage-dependent efflux in the following order : scn- greater than i- greater than no3- greater than br- approximately acetate approximately cl- greater than f- approximately so42- greater than hpo42- , gluconate , and isethionate . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
0,
6
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
242,
243
]
} |
anions stimulate voltage-dependent efflux in the following order : scn- greater than i- greater than no3- greater than br- approximately acetate approximately cl- greater than f- approximately so42- greater than hpo42- , gluconate , and isethionate . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
0,
6
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
176,
177
]
} |
with two of the serine proteases involved in fibrinolysis , the rate of acylation with fde is also fast , k2 = 0.112 s-1 for urokinase and 0.799 s-1 for plasmin , and the rate of deacylation is slow , k3 = 3.64 x 10 ( -4 ) s-1 for urokinase and 6.27 x 10 ( -6 ) s-1 for plasmin . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
16,
32
]
} | {
"id": "C0016016",
"name": "plasmin",
"pos": [
270,
277
]
} |
phytochrome transformation from the pr to the pfr form exhibits a small deuterium isotope effect , in tris-d2o upon irradiation with red light , only after a photocycling of the phytochrome . | NA | {
"id": "C0031857",
"name": "phytochrome",
"pos": [
0,
11
]
} | {
"id": "C0250581",
"name": "a",
"pos": [
156,
157
]
} |
two covalently modified derivatives of the apoprotein of the blue copper protein stellacyanin have been prepared . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
43,
53
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
73,
80
]
} |
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