text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the method was applied to a variety of recombinant plasmid dnas which were constructed by inserting dna , poly ( da ) . poly ( dt ) or poly ( da-dt ) . poly ( da-dt ) into pbr322 dna . | NA | {
"id": "C0012931",
"name": "constructed",
"pos": [
75,
86
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
179,
182
]
} |
the role of iodide and of free diiodotyrosine in enzymatic and non-enzymatic thyroid hormone synthesis . | NA | {
"id": "C0012344",
"name": "diiodotyrosine",
"pos": [
31,
45
]
} | {
"id": "C0040135",
"name": "thyroid hormone",
"pos": [
77,
92
]
} |
as judged by translational activity in a cell-free protein-synthesizing system derived from rabbit reticulocytes , albumin mrna was enriched 259-fold as compared to the total ribonucleic acid of the liver cells . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
51,
58
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
115,
122
]
} |
a high-speed supernatant from rat liver contains at least two latent phosphorylase phosphatases the activities of which are revealed by treatment with ethanol , urea , mercaptoethanol or trypsin . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
151,
158
]
} | {
"id": "C0025402",
"name": "mercaptoethanol",
"pos": [
168,
183
]
} |
activation of the latent phosphorylase phosphatases by ethanol , urea or mercaptoethanol is not accompanied by the destruction of the precursor of the inhibitory protein whereas activation by trypsin is . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
55,
62
]
} | {
"id": "C0025402",
"name": "mercaptoethanol",
"pos": [
73,
88
]
} |
furthermore , some protein fractions , almost free of the precursor of the inhibitory protein can be readily activated by trypsin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
19,
26
]
} | {
"id": "C0033665",
"name": "precursor",
"pos": [
58,
67
]
} |
it is a mixture of two homologous lipopeptides : the lipid moiety consists of 3-amino-12-methyltridecanoic acid or 3-amino-12-methyltetradecanoic acid ; | NA | {
"id": "C2266975",
"name": "lipopeptides",
"pos": [
34,
46
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
53,
58
]
} |
hydrogenation of double bonds of fatty acyl chains in the lipids of individual , intact plasma lipoproteins has been accomplished using a water-soluble , homogenous catalyst . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
58,
64
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
95,
107
]
} |
if this is the case , it is speculated that the known exchange of these neutral lipids between the lipoprotein classes and their degradation by lipolytic enzymes may thus be facilitated . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
80,
86
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
99,
110
]
} |
succinyl juvenile hormone was also coupled to the peptide glycyltyrosine and iodinated so as to form a water-soluble 125i-labelled analogue well recognized by antibodies ( 60 % bound by the 1/2000 000 dilution of antiserum routinely used in radioimmunoassay ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
159,
169
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
213,
222
]
} |
the enzymes has been purified by deae-cellulose , phosphocellulose and double-stranded dna cellulose chromatography and its properties compared to those of its nuclear-cytosolic counterpart purified by the same purification steps . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
33,
47
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
91,
100
]
} |
in view of improving fixation and embedding for thin sections of nuclear material we investigated the crosslinking of selected proteins , nucleic acid and nucleoproteins by observing the eventual gelation of solutions of these substances , which might be produced by current cytological fixatives . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
127,
135
]
} | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
155,
169
]
} |
therefore , the demonstration of atpase stimulation by chloride strongly depends on the type and concentration of the buffer used and may also largely interfere with the stimulation caused by other anions present in the incubation medium . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
55,
63
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
198,
204
]
} |
of the inorganic anions tested chloride and bicarbonate appear to be the favorite physiological activators , but the possible role of carbonic acids in the stimulation of the anion-dependent atpase should not be neglected . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
31,
39
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
175,
180
]
} |
incubation media adapted for the simultaneous demonstration of both chloride and bicarbonate activation contained 10 to 20 mm histidine-tris buffer at ph 8.0 to 8.5 , 150 mm sucrose , 0.2 mm ouabain , 0.5 mm magnesium acetate , 1 mm atp , ( ph adjusted to 8.0-8.5 with tris or naoh ) , with and without 25 mm sodium chlo... | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
68,
76
]
} | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
309,
324
]
} |
incubation media adapted for the simultaneous demonstration of both chloride and bicarbonate activation contained 10 to 20 mm histidine-tris buffer at ph 8.0 to 8.5 , 150 mm sucrose , 0.2 mm ouabain , 0.5 mm magnesium acetate , 1 mm atp , ( ph adjusted to 8.0-8.5 with tris or naoh ) , with and without 25 mm sodium chlo... | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
81,
92
]
} | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
334,
352
]
} |
the effect of preoperative infusion of benzylpenicillin , carbenicillin , ampicillin , chloramphenicol and doxycycline on hemostasis after standardized liver resection was studied in the rat . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
39,
55
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
58,
71
]
} |
the effect of preoperative infusion of benzylpenicillin , carbenicillin , ampicillin , chloramphenicol and doxycycline on hemostasis after standardized liver resection was studied in the rat . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
39,
55
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
74,
84
]
} |
platelet function , assayed by adp- and collagen-induced platelet aggregation was impaired in benzylpenicillin- , carbenicillin- and chloramphenicol-treated animals . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
94,
110
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
114,
127
]
} |
previous studies have shown that local instillation of the mucopolysaccharide heparin can prevent bacterial adsorption on the bladder mucosa denuded of this `` '' antiadherence factor '' '' . | NA | {
"id": "C0017973",
"name": "mucopolysaccharide",
"pos": [
59,
77
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
78,
85
]
} |
to determine whether this action was due to the mucopolysaccharide composition of heparin , or rather to its anticoagulant property , protamine sulfate ( a basic protein with anticoagulant properties ) was tested for antiadsorptive efficacy . | NA | {
"id": "C0017973",
"name": "mucopolysaccharide",
"pos": [
48,
66
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
82,
89
]
} |
we compared our ability to predict the dose of medigoxin and of digoxin required to achieve a fixed serum concentration ( the dose requirement ) in 33 outpatients . | NA | {
"id": "C0025132",
"name": "medigoxin",
"pos": [
47,
56
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
64,
71
]
} |
we were not able to predict the dose requirement from patient characteristics with any more certainty for medigoxin than for digoxin . | NA | {
"id": "C0025132",
"name": "medigoxin",
"pos": [
106,
115
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
125,
132
]
} |
when comparing medigoxin with digoxin of lower , or more variable dissolution rate , medigoxin may be preferable . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
17,
24
]
} | {
"id": "C0025132",
"name": "medigoxin",
"pos": [
85,
94
]
} |
the ppd-specific enhancing effect on the leukocyte tp activity could be transferred by soluble factor ( s ) from stimulated lymphocytes to purified monocytes , which suggests that the effect is , at least partially , mediated by lymphokine ( s ) . | NA | {
"id": "C0040673",
"name": "transferred",
"pos": [
72,
83
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
229,
239
]
} |
the coenzyme d-biotin offers in its anionic form to metal ions 3 possible binding sites : the carboxylate group of the valerate side chain , the ureido residue of the 2-imidazolidone ring , and the thioether sulfur of the tetrahydrothiophene ring ; | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
4,
12
]
} | {
"id": "C0005575",
"name": "biotin",
"pos": [
15,
21
]
} |
calvaria cells were separated into periosteal and bone cells and cultured in the presence of ethane-1-hydroxy-1,1-diphosphonate ( ehdp ) or dichloromethanediphosphonate ( cl2mdp ) . | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
114,
127
]
} | {
"id": "C0012081",
"name": "cl2mdp",
"pos": [
171,
177
]
} |
although both body weight and reproductive condition vary on an infradian basis , the changes in body weight appear to be programmed independently from changes in gonadal function . | NA | {
"id": "C0005910",
"name": "body weight",
"pos": [
14,
25
]
} | {
"id": "C0005911",
"name": "changes",
"pos": [
152,
159
]
} |
the sum of noradrenaline and adrenaline in freshly collected semen was 10 ng/ml ( 5.2 x 10 ( -8 ) m ) , i.e. , about 100 times lower than previously reported . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
11,
24
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
29,
39
]
} |
is the mitochondrial dicyclohexylcarbodiimide-reactive protein of mr 33 000 identical with the phosphate transport protein ? | NA | {
"id": "C0949610",
"name": "mitochondrial",
"pos": [
7,
20
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
115,
122
]
} |
whereas normal fibroblasts are protected by if , virus-infected cells and most tumor-derived cells are not . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
15,
26
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
93,
98
]
} |
twelve steroids measured in plasma were pregnenolone ( preg ) . , 17-oh pregnenolone ( 17preg . ) , progesterone ( prog . ) , 17-oh progesterone ( 17prog . ) , 11-deoxycorticosterone ( doc ) , corticosterone ( b ) , aldosterone ( ald . ) , 11-deoxycortisol ( s ) , cortisol ( f ) , dehydroepiandrosterone ( dha ) , andro... | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
40,
52
]
} | {
"id": "C0376260",
"name": "17-oh pregnenolone",
"pos": [
66,
84
]
} |
twelve steroids measured in plasma were pregnenolone ( preg ) . , 17-oh pregnenolone ( 17preg . ) , progesterone ( prog . ) , 17-oh progesterone ( 17prog . ) , 11-deoxycorticosterone ( doc ) , corticosterone ( b ) , aldosterone ( ald . ) , 11-deoxycortisol ( s ) , cortisol ( f ) , dehydroepiandrosterone ( dha ) , andro... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
100,
112
]
} | {
"id": "C0020387",
"name": "17-oh",
"pos": [
126,
131
]
} |
a stock solution ( 0.1mg/ml of norepinephrine , 0.1mg/ml of epinephrine and 2.0mg/ml of dopamine ) was stored in 0.2n ch3cooh at 4 degrees c , and was diluted at 1/5,000-1/40,000 when needed . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
31,
45
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
60,
71
]
} |
[ the determination of unconjugated estrone , estradiol , estriol and estetrol in serum or amniotic fluid by high performance liquid chromatography with an amperometric detector ( author 's transl ) ] . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
58,
65
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
70,
78
]
} |
a simultaneous microdetermination of unconjugated estrone , estradiol , estriol and estetrol in serum or amniotic fluid by high performance liquid chromatography with an amperometric detector is described . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
72,
79
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
84,
92
]
} |
the sample solution was applied to hplc using a reverse phase ods column and acetonitrile : 0.1m kh2 po4 47:53 for estrone and estradiol fraction , and 30:70 for estriol and estetrol fraction as a mobile phase , respectively . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
162,
169
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
174,
182
]
} |
[ the concentration of serum unconjugated estradiol , estriol and estetrol in pregnant women , and the significance of these hormones in pregnancy ( author 's transl ) ] . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
54,
61
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
66,
74
]
} |
simultaneous determinations of unconjugated estradiol ( e2 ) , estriol ( e3 ) and 15 alpha-hydroxyestriol ( e4 ) levels in maternal serum were studied serially to ascertain the significance of these estrogens in the feto-placental unit . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
63,
70
]
} | {
"id": "C0014899",
"name": "15",
"pos": [
82,
84
]
} |
the effect of treatment was evaluated clinically on the basis of occurrence of pruritus , erythema and eruptions as well as subjectively through the patients own opinion about the condition of their skin . | NA | {
"id": "C0033774",
"name": "pruritus",
"pos": [
79,
87
]
} | {
"id": "C0037274",
"name": "condition of",
"pos": [
180,
192
]
} |
the effect of treatment was evaluated clinically on the basis of occurrence of pruritus , erythema and eruptions as well as subjectively through the patients own opinion about the condition of their skin . | NA | {
"id": "C0041834",
"name": "erythema",
"pos": [
90,
98
]
} | {
"id": "C0037274",
"name": "condition of",
"pos": [
180,
192
]
} |
experiments with 125i-labelled albumin and igg showed that both proteins were actively internalised by placental villi giving credence to the idea that secretion is triggered after uptake . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
31,
38
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
64,
72
]
} |
the synthesis of soluble proteins in human endometria at various phases of menstrual cycle was evaluated by polyacrylamide gel electrophoresis of [ 35s ] methionine-labeled proteins . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
4,
13
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
173,
181
]
} |
simultaneous occurrence of hyperglycaemia ( up to 300 mg/100 ml ) and hyperinsulinaemia ( up to 1200 mu u/ml ) was evident in the fed state in genetically diabetic kk mice , indicating insulin resistance . | NA | {
"id": "C0020459",
"name": "hyperinsulinaemia",
"pos": [
70,
87
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
185,
203
]
} |
4 ) r-r cycle of the reciprocating tachycardia , antegrade and retrograde conduction time ( after identification of the reentry circuit ) and pattern of induction and interruption of the tachycardia . | NA | {
"id": "C0242514",
"name": "reciprocating",
"pos": [
21,
34
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
187,
198
]
} |
this trend was seen not only with individual tumors , but also among tumors of various histological types . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
45,
51
]
} | {
"id": "C0027652",
"name": "tumors of",
"pos": [
69,
78
]
} |
the radioactive products obtained from enzymatic hydrolysates of polylysine that had been reacted with 1,1'ethylene-bis ( 1-nitrosourea ) ( ebnu ) [ carbonyl-14c ] and ebnu [ ethylene-14c ] coincided with the authentic samples of ca-lys , inc-lys , and hec-lys on thin-layer chromatography . | NA | {
"id": "C0032518",
"name": "polylysine",
"pos": [
65,
75
]
} | {
"id": "C0024337",
"name": "lys",
"pos": [
257,
260
]
} |
when cells from various sources were treated with aclacinomycin a , they were affected at a similar concentration with the exception of human normal fibroblasts , which were a little less sensitive than the others . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
5,
10
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
149,
160
]
} |
the antitumor activity of this compound was superior to those of 5-fu and 1- ( 2-tetrahydrofuryl ) -5-fluorouracil ( tegafur , ftorafur ) in the treatment of transplantable tumors , not only 5-fu-sensitive tumors such as adenocarcinoma 755 , lymphosarcoma ls-1 , and plasmacytoma x5563 , but also 5-fu-resistant tumors s... | NA | {
"id": "C0016778",
"name": "tegafur",
"pos": [
117,
124
]
} | {
"id": "C0016360",
"name": "fu",
"pos": [
299,
301
]
} |
serum prealbumin and albumin levels , hepaplastin tests , nitrogen balance and molar ratio of serum bcaa and aromatic amino acid ( aaa ) were mostly improved during 2 weeks of the special diet supplemented with daily 5 g bcaa in three meals . | NA | {
"id": "C0002520",
"name": "bcaa",
"pos": [
100,
104
]
} | {
"id": "C0002521",
"name": "bcaa",
"pos": [
221,
225
]
} |
of the total 199 patients who experienced gastrointestinal bleeding , 95 ( 48 % ) bled from esophageal or gastric varices , 67 ( 34 % ) bled from peptic ulcer or gastritis , and 37 ( 18 % ) had either insufficient evidence of the source ( 33 ) or mixed sources ( 4 ) . | NA | {
"id": "C0017181",
"name": "gastrointestinal bleeding",
"pos": [
42,
67
]
} | {
"id": "C0030922",
"name": "bled",
"pos": [
136,
140
]
} |
however , fecal porphyrin excretion was markedly increased to 406 micrograms/g dry stool weight ( normal range less than 100 micrograms/g ) constituted predominantly of protoporphyrin 225 micrograms/g ( normal range less than 76 micrograms/g ) , . | NA | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
16,
25
]
} | {
"id": "C0033733",
"name": "protoporphyrin",
"pos": [
169,
183
]
} |
to establish the mechanism of progression to chronicity of the hbsag-associated delta infection , serum hepatitis b virus and delta markers were tested in five babies born to hbsag-positive mothers with anti-delta , in 42 follow-up patients with acute hepatitis b virus and delta hepatitis , and in collections of sera f... | NA | {
"id": "C0524911",
"name": "chronicity",
"pos": [
45,
55
]
} | {
"id": "C0011226",
"name": "delta hepatitis",
"pos": [
274,
289
]
} |
the antigen structure of human transferrin consists of at least 6 different antigen determinants designated as a1 , b1 , b2 , b3 , b4 , and c1 in accordance with their being included in the corresponding antigen determinant group . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
4,
11
]
} | {
"id": "C0003316",
"name": "antigen determinant",
"pos": [
204,
223
]
} |
neutralization of heparin by basic proteins of tumor cells : studies in vitro with protein rich in 14c-arginine . | NA | {
"id": "C0027642",
"name": "proteins",
"pos": [
35,
43
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
83,
90
]
} |
3 ) rabbits with subacute bronchitis were prepared by long-term exposure to air contaminated with so2 gas and sputa were collected before and after administration of nac , respectively , according to the kase 's method . | NA | {
"id": "C0038777",
"name": "so2",
"pos": [
98,
101
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
102,
105
]
} |
the basal levels of the other anterior pituitary hormones ( growth hormone and thyroid-stimulating hormone ) as well as their provocative responses to thyrotropin-releasing hormone also distinguished the alcoholics from the hemophiliac population . | NA | {
"id": "C0032016",
"name": "anterior pituitary hormones",
"pos": [
30,
57
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
60,
74
]
} |
the basal levels of the other anterior pituitary hormones ( growth hormone and thyroid-stimulating hormone ) as well as their provocative responses to thyrotropin-releasing hormone also distinguished the alcoholics from the hemophiliac population . | NA | {
"id": "C0032016",
"name": "anterior pituitary hormones",
"pos": [
30,
57
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
151,
162
]
} |
in contrast , activation of the reticuloendothelial system by glucan increased galactosamine-induced alterations in serum bilirubin , glucose and cholesterol concentrations , glutamic oxalacetic transaminase , glutamic pyruvic transaminase and lactic dehydrogenase activities , and sodium sulfobromophthalein retention . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
195,
207
]
} | {
"id": "C0001899",
"name": "glutamic pyruvic transaminase",
"pos": [
210,
239
]
} |
suppressor t-cell activity measured by a concanavalin a-induced suppressor system using allogeneic responder cells was dependent on which individual was selected as a source of responder cells . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
88,
98
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
187,
192
]
} |
this study demonstrates the importance of the proper identification of these cells in cytological material and gives support to the theory that these cells play a role as a precursor cell to squamous and glandular neoplasms . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
77,
82
]
} | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
173,
187
]
} |
sex reversed mice ( sxr ) show a dna arrangement of these sequences in conformity with their phenotypic sex , suggesting that this dna is closely connected with the determination of sex . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
31,
36
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
131,
134
]
} |
since amniotic cells , lymphocytes , and fibroblasts of this child exhibited both high spontaneous breakage of chromosomes and sensitivity to the bivalent alkylant , diepoxybutane , a correlation between the findings on cytogenetic and enzymologic levels is assumed . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
15,
20
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
41,
52
]
} |
human sera containing dextran-reactive antibodies of various immunoglobulin classes were tested for their capacity to induce adcc against dextran-coated chicken red blood cells ( crbc ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
39,
49
]
} | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
61,
75
]
} |
gp 220 is different from fibronectin and spectrin , proteins which also show binding to the ulex europaeus lectin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
52,
60
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
107,
113
]
} |
the results obtained suggest that the antibodies of serum , mar , react with blood group m determinants modified by formation of a glycosylamine linkage between amino groups of the glycoprotein and glucose or other hexoses with the same configuration at asymmetric carbons 3 , 4 and 5 as glucose . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
198,
205
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
215,
222
]
} |
immunoelectrophoretic development of venom-complement mixtures with anti c3 proactivator revealed the appearance of the c3 activator . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
43,
53
]
} | {
"id": "C0033453",
"name": "c3 proactivator",
"pos": [
73,
88
]
} |
this non-invasive technique of cardiac output monitoring may therefore have an important place in the investigation of cardiac function after trauma and burn injury . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
142,
148
]
} | {
"id": "C0006434",
"name": "burn injury",
"pos": [
153,
164
]
} |
a locus ( classical histocompatibility antigens ) of the bn strain , a locus from the bn strain that codes for the expression of an ia antigen and strong mixed lymphocyte response ( mlr ) , and a second locus derived from the p1 haplotype that controls the expression of a second ia antigen , the ability to elicit a str... | NA | {
"id": "C0019628",
"name": "histocompatibility antigens",
"pos": [
20,
47
]
} | {
"id": "C0019630",
"name": "ia antigen",
"pos": [
280,
290
]
} |
in contrast , mb40.3 recognizes an antigenic determinant which is less variable between b7 and b40 and more closely approximates a public antigen or common antigenic site . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
35,
56
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
156,
165
]
} |
gallic acid ( ga ) is a common part of the human diet , both in the free form and as a metabolite of tannic acid and propyl gallate . | NA | {
"id": "C0016979",
"name": "gallic acid",
"pos": [
0,
11
]
} | {
"id": "C0033501",
"name": "propyl gallate",
"pos": [
117,
131
]
} |
adsorption inhibition activity of antiserum to strain t14v , previously shown to be solely related to antibodies in immune serum directed against the va1 fimbria ( fibril ) antigen , was removed by preadsorption of the antiserum with most a. viscosus and a. naelundii strains , but not with a. israelii strains . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
102,
112
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
219,
228
]
} |
furthermore , it is not only anesthetic doses that impair the reflex respiratory responses , but also subanesthetic doses of inhalational anesthetics and premedicant doses of barbiturates and narcotics . | NA | {
"id": "C0002932",
"name": "anesthetic",
"pos": [
29,
39
]
} | {
"id": "C0242903",
"name": "inhalational",
"pos": [
125,
137
]
} |
one of the kbg antigens with cathodal mobility -- the major component of the previously isolated allergen c -- was identified as immunologically identical to timothy ag 30 . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
15,
23
]
} | {
"id": "C0002092",
"name": "allergen",
"pos": [
97,
105
]
} |
those antigens that were recognized as allergens by all of the allergic sera examined were regarded as candidates for future isolation and characterization . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
6,
14
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
39,
48
]
} |
the soluble fraction and membrane-associated tatas from both tumors could be specifically bound to liposomes in reconstitution experiments and the antigenicity of all of the tatas was significantly enhanced when they were incorporated into these artificial membranes . | NA | {
"id": "C0023828",
"name": "liposomes",
"pos": [
99,
108
]
} | {
"id": "C0025256",
"name": "artificial",
"pos": [
246,
256
]
} |
rous sarcoma virus ( rsv ) -transformed fibroblasts from different animals species a serologically detectable virus-induced non-virion cell surface antigen ( vcsa ) , whose expression is controlled by the transforming viral src gene and by a cellular gene . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
40,
51
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
242,
250
]
} |
it is concluded that the expression of both the serologically-defined vcsa and the transplantation antigen is the result of the interaction of pp60src with host cell gene product ( s ) rather than the simple exposure of pp60src at the outer cell surface . | NA | {
"id": "C0003339",
"name": "vcsa",
"pos": [
70,
74
]
} | {
"id": "C0019628",
"name": "transplantation antigen",
"pos": [
83,
106
]
} |
the coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
59,
70
]
} |
the virus was rescued from the pr rsh-9 cell line by cell fusion with chicken fibroblasts and from the other two lines ( pr rsh-12 and pr rsh-14 ) and clones only if chicken fibroblasts used for fusion had been preinfected with a helper virus . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
40,
44
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
174,
185
]
} |
this pronounced mitogenic activity was highly dependent on the presence of monocytes : removal of these cells from pmbc suspensions by complement ( c ) -dependent lysis with the antimonocyte antibody okm1 , completely abrogated the proliferative responsiveness of the remaining lymphocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
104,
109
]
} | {
"id": "C1321301",
"name": "pmbc",
"pos": [
115,
119
]
} |
moreover , aggregated human igg and its fc fragments ( but not monomeric igg and its fab fragments ) inhibited the mitogenicity of okt3 : their inhibition could be explained by stimulation of monocytes , resulting in increased prostaglandin e release , since ( a ) prostaglandin e2 itself strongly suppressed okt3 activi... | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
227,
242
]
} | {
"id": "C0012472",
"name": "prostaglandin e2",
"pos": [
265,
281
]
} |
three t cell surface proteins , two defined by the monoclonal antibodies okt6 and okt10 , recognize proteins which resemble hla antigens physiochemically . | NA | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
13,
29
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
100,
108
]
} |
neoplastic lymphocytes from patients with varying phases of cutaneous t cell lymphoma ( mycosis fungoides , sezary syndrome and related presentations ) were reactive with okt1 and okt3 ( pan t cell reagents ) and okt4 ( an antibody defining the functional `` '' helper '' '' t cell subset ) . | NA | {
"id": "C0079773",
"name": "of cutaneous t cell lymphoma",
"pos": [
57,
85
]
} | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
108,
123
]
} |
a modest number of patients with active arthritis were treated wit levamisole or with synthetic thymopoietin 32-36 ( thymopoietin pentapeptide or tp-5 ) . | NA | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
96,
108
]
} | {
"id": "C0080225",
"name": "tp-5",
"pos": [
146,
150
]
} |
a case-control mortality study conducted in 20 parishes ( countries ) of south louisiana to determine what relationship drinking mississippi river water might have on mortality from colon or rectal cancer , found a significant risk for rectal cancer associated with surface water . | NA | {
"id": "C0599638",
"name": "drinking",
"pos": [
120,
128
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
274,
279
]
} |
data from the honolulu heart study suggest that the examining physician 's clinical diagnosis , based on questioning the subject about chest pain , was more sensitive than the rose questionnaire in detecting angina pectoris in a population of japanese men . | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
135,
145
]
} | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
208,
223
]
} |
extension of this method of analysis to denatured proteins , biopolymers and other polymers is also outlined . | NA | {
"id": "C0005554",
"name": "biopolymers",
"pos": [
61,
72
]
} | {
"id": "C0032521",
"name": "polymers",
"pos": [
83,
91
]
} |
two patients complaining of palpitation during intercourse developed supraventricular tachycardia ( svt ) and two sinus tachycardia . | NA | {
"id": "C0039240",
"name": "supraventricular",
"pos": [
69,
85
]
} | {
"id": "C0039239",
"name": "sinus tachycardia",
"pos": [
114,
131
]
} |
mycoplasmal toxins cover a wide range of substances , including diffusible components of microbial metabolism that are toxic for host cells , endotoxin-like compounds in the mycoplasma membrane , or toxins with characteristics of some classical exotoxins . | NA | {
"id": "C0040549",
"name": "toxins",
"pos": [
12,
18
]
} | {
"id": "C0015309",
"name": "exotoxins",
"pos": [
245,
254
]
} |
a method is described for the determination of ethanol in the presence of methanol without pre-separation . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
47,
54
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
74,
82
]
} |
the supernatant liquid is removed , dried under a nitrogen steam , and dissolved in water for final extraction by reverse phase chromatography . | NA | {
"id": "C0038225",
"name": "steam",
"pos": [
59,
64
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
84,
89
]
} |
levels of h+ and other monovalent cations in dormant and germinating spores of bacillus megaterium . | NA | {
"id": "C0033727",
"name": "h",
"pos": [
10,
11
]
} | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
23,
41
]
} |
these data indicate ( i ) that between ph 6.2 and 7.8 internal spore ph has little effect on dormant spore properties , ( ii ) that there is a strong permeability barrier in dormant spores to movement of charged molecules and small uncharged molecules , and ( iii ) that extremely early in spore germination this permeab... | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
383,
401
]
} | {
"id": "C0033727",
"name": "h",
"pos": [
404,
405
]
} |
lack of chemotactic response to tricarboxylic acids by escherichia coli carrying a plasmid determining citrate utilization . | NA | {
"id": "C0040887",
"name": "tricarboxylic acids",
"pos": [
32,
51
]
} | {
"id": "C0008857",
"name": "citrate",
"pos": [
103,
110
]
} |
salmonella typhimurium but not citrate-utilizing escherichia coli carrying the cit plasmid showed positive chemotaxis to tricarboxylic acids , indicating that the cit plasmid encodes a transport system but not a chemoreceptor for citrate . | NA | {
"id": "C0040887",
"name": "tricarboxylic acids",
"pos": [
121,
140
]
} | {
"id": "C0008857",
"name": "citrate",
"pos": [
230,
237
]
} |
connectin , an elastic protein of muscle ( maruyama et al . 1977 ) , can be isolated by a similar method from thoroughly extracted muscle residues . | NA | {
"id": "C0056248",
"name": "connectin",
"pos": [
0,
9
]
} | {
"id": "C0026832",
"name": "protein",
"pos": [
23,
30
]
} |
an enzymatic sequencing method on gels using 32p-labeled rna at the 5 ' end ( 2 ) and conventional sequence analyses of the complete digests of the unlabeled rna with rnase t1 [ ec 3.1.27.3 ] and rnase a [ ec 3.1.27.5 ] were used for complete determination of the total sequence . | NA | {
"id": "C0018364",
"name": "rnase t1",
"pos": [
167,
175
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
196,
201
]
} |
unlike the soluble phosphatase , freezing in the presence of mercaptoethanol or by precipitation with ethanol failed to activate or to solubilize the membrane-bound phosphatase . | NA | {
"id": "C0025402",
"name": "mercaptoethanol",
"pos": [
61,
76
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
102,
109
]
} |
alpha ( 1 leads to 6 ) specific anti-dextran antibody was raised in rabbits by injecting n4 dextran-concanavalin a conjugate , and the interactions of five synthetic linear dextrans ( alpha ( 1 leads to 6 ) -d-glucopyranans ) with rabbit anti-n4 dextran were studied . | NA | {
"id": "C0011806",
"name": "dextrans",
"pos": [
173,
181
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
246,
253
]
} |
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