text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the apparent concentrations of vanadate giving half-maximal inhibition of mg-atpase activity of various dynein fractions were as follows : the axoneme-bound form of dynein at 100 nm , solubilized crude dynein at 50 nm , 14s dynein at 5 microm , and 30s dynein at 20 nm . | NA | {
"id": "C1180333",
"name": "axoneme",
"pos": [
143,
150
]
} | {
"id": "C0013352",
"name": "dynein",
"pos": [
253,
259
]
} |
for the support of this contention , total mouse dna , purified main-band dna , and purified satellite dna were digested with ecori , sedimented in a sucrose gradient , and hybridized with labeled satellite crna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
49,
52
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
93,
106
]
} |
we have compared the respective abilities of porcine insulin and [ leub25 ] insulin to enhance the rate of dissociation of receptor-bound [ 125i ] insulin from im-9 lymphocytes and isolated rat adipocytes and to increase the rate of adipocyte glucose transport and oxidation . | NA | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
45,
60
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
147,
154
]
} |
although porcine insulin ( 100 ng/ml ) greatly enhanced the dissociation rate of previously bound [ 125i ] insulin , [ leub25 ] insulin ( at a concentration yielding equivalent receptor occupancy ) had no effect . | NA | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
9,
24
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
128,
135
]
} |
in addition to a general influence of ionic strength , specific anion effects are found for phosphate , chloride and morpholinosulphonate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
64,
69
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
92,
101
]
} |
in addition to a general influence of ionic strength , specific anion effects are found for phosphate , chloride and morpholinosulphonate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
64,
69
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
104,
112
]
} |
these observations are interpreted as being the result of a rapid turnover of atp stimulating phosphocreatine production by the mitochondrial isozyme of creatine kinase ( atp : creatine n-phosphotransferase , ec 2.7.3.2 ) . | NA | {
"id": "C0914594",
"name": "mitochondrial",
"pos": [
128,
141
]
} | {
"id": "C0010287",
"name": "creatine",
"pos": [
177,
185
]
} |
the shift in fusion temperature of the spherical phospholipid membranes due to the change of ph is explained by the shift in phase transition temperatures of lipid membranes . | NA | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
49,
61
]
} | {
"id": "C0025249",
"name": "lipid membranes",
"pos": [
158,
173
]
} |
liver plasma membranes so prepared consisted almost exclusively of vesicles by electron microscopy , showed some contamination with endoplasmic reticulum and minimal contamination with mitochondria or golgi by marker enzymes , were highly enriched in alkaline phosphatase , mg2+-atpase , and 5'-nucleotidase activity com... | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
274,
277
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
390,
396
]
} |
fractionation of glycoconjugates by repeated chromatography on columns of sepharose cl-6b and deae-sepharose and by affinity chromatography on wga-sepharose yielded three radiochemically homogeneous glycoproteins . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
17,
32
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
199,
212
]
} |
the process is stimulated by a membrane potential ( negative inside ) as demonstrated by the effect of the ionophores valinomycin and carbonyl cyanide m-chlorophenylhydrazone and anions with different permeabilities . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
143,
150
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
179,
185
]
} |
the receptor appears to bind to rna ( mrna , trna , rrna ) as well as to dna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
32,
35
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
52,
56
]
} |
the purified enzyme , as well as crude enzyme preparations , catalyses the phosphorolysis of thymidine and deoxyuridine , but not of uridine , and is able to catalyse direct pentosyl transfer from these deoxyribonucleosides to uracil or thymine ; | NA | {
"id": "C0040077",
"name": "thymidine",
"pos": [
93,
102
]
} | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
203,
223
]
} |
the purified enzyme , as well as crude enzyme preparations , catalyses the phosphorolysis of thymidine and deoxyuridine , but not of uridine , and is able to catalyse direct pentosyl transfer from these deoxyribonucleosides to uracil or thymine ; | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
107,
119
]
} | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
203,
223
]
} |
the purified enzyme , as well as crude enzyme preparations , catalyses the phosphorolysis of thymidine and deoxyuridine , but not of uridine , and is able to catalyse direct pentosyl transfer from these deoxyribonucleosides to uracil or thymine ; | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
227,
233
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
237,
244
]
} |
the major crystallizable isozyme of this enzyme from yeast is , however , considerably more acidic than the helix-destabilizing protein , and displays significantly lower helix-destabilizing activity . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
25,
32
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
41,
47
]
} |
unsaturated fatty acids acted as more potent inhibitors of the purified enzyme , although the addition of atp increased the i0.5 values for these fatty acids . | NA | {
"id": "C0015690",
"name": "unsaturated fatty",
"pos": [
0,
17
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
146,
157
]
} |
( 2 ) unsaturated fatty acids showed a powerful inhibition of the in situ amp deaminase , and the presence of atp could scarcely affect the inhibition of the in situ enzyme by these fatty acids . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
6,
29
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
182,
193
]
} |
diethyl pyrocarbonate inactivates enoyl-coa hydratase ( l-3-hydroxyacyl-coa hydro-lyase , ec 4.2.1.17 ) with a second-order rate constant of 1.3 m-1 x s-1 . | NA | {
"id": "C0014314",
"name": "enoyl-coa hydratase",
"pos": [
34,
53
]
} | {
"id": "C0020239",
"name": "hydro-lyase",
"pos": [
76,
87
]
} |
1 mm free mg2+ concentration have revealed that the enzyme has two distinct sites , one for nucleoside diphosphate or nucleoside triphosphate and the other for carbamyl phosphate or carbamate , and its reaction with the substrates is of the random type . | NA | {
"id": "C0006960",
"name": "carbamyl phosphate",
"pos": [
160,
178
]
} | {
"id": "C0006948",
"name": "carbamate",
"pos": [
182,
191
]
} |
poly ( ethylene glycol ) of 5 000 daltons has been attached covalently to preparations of urate oxidase ( urate : oxygen oxidoreductase , ec 1.7.3.3 ) from hog liver and candida utilis . | NA | {
"id": "C0041931",
"name": "urate oxidase",
"pos": [
90,
103
]
} | {
"id": "C0030016",
"name": "oxidoreductase",
"pos": [
121,
135
]
} |
the increase in choline incorporation is primarily due to an increased specific activity of phosphorylcholine resulting from a decreased pool size of phosphorylcholine . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
16,
23
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
150,
167
]
} |
analysis of apolipoprotein concentrations by electroimmunoassay showed hepatectomy did not affect the total serum concentrations of apolipoproteins b and e ; | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
12,
26
]
} | {
"id": "C0003593",
"name": "apolipoproteins b",
"pos": [
132,
149
]
} |
human serum albumin , the purity of which was confirmed by two-dimensional gel electrophoresis and high-pressure liquid chromatography , is able to bind dipalmitoyl phosphatidylcholine and the resulting albumin-phospholipid complex can cause marked sterol release from animal and human cells in tissue culture . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
0,
19
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
203,
210
]
} |
synthesis and release of lipids and lipoproteins by isolated rat jejunal enterocytes in the presence of sodium taurocholate . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
25,
31
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
36,
48
]
} |
the cross-link , lysylnorleucine , may be evidence of covalent bonding of glycoprotein to elastin , explaining my inability to obtain the biopolymer elastin with the composition of tropoelastin corrected for the desmosine-lysine content . | NA | {
"id": "C0005554",
"name": "biopolymer",
"pos": [
138,
148
]
} | {
"id": "C0013765",
"name": "tropoelastin",
"pos": [
181,
193
]
} |
we have separated whole plasma by ultracentrifugation into lipoprotein-rich and lipid-deficient fractions and demonstrated that glucocerebroside and antithrombin iii clearly separate into different fractions . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
59,
70
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
80,
85
]
} |
the glycosyltransferase activities incorporating n-acetyl [ 1-14c ] galactosamine and [ u-14c ] galactose from uridine diphosphate n-acetyl [ 1-14c ] galactosamine and uridine diphosphate [ u-14c ] galactose , respectively , were measured after membrane solubilization with triton x-100 either with unglycosylated casein... | NA | {
"id": "C0016943",
"name": "galactosamine",
"pos": [
68,
81
]
} | {
"id": "C0001055",
"name": "n-acetylgalactosamine",
"pos": [
376,
397
]
} |
the isolation procedure included separation of nucleic acids on deae-cellulose , affinity chromatography on dna-agarose and chromatography on deae-sephadex . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
47,
60
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
108,
111
]
} |
using this modification , the major forms of lysophosphatides , i. e. lysophosphatidylcholines , lysophosphatidylethanolamines , lysocardiolipids , lysophosphatidic acids , lysophosphatidylserines , etc. , and their diacyl analogs were isolated from mitochondrial and reticulum membranes and identified . | NA | {
"id": "C0024360",
"name": "lysophosphatidylcholines",
"pos": [
70,
94
]
} | {
"id": "C0024367",
"name": "lysophosphatidic acids",
"pos": [
148,
170
]
} |
undernutrition increased the number of fetal resorptions in the 3rd week of pregnancy and depressed placental and fetal weights in both sexes , although there was some relative sparing of fetal brain weight . | NA | {
"id": "C0751992",
"name": "fetal weights",
"pos": [
114,
127
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
200,
206
]
} |
because of the approximate parallelity in the changes in the rates of production and utilization of glucose , no consistent change in blood glucose was observed during cooling . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
100,
107
]
} | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
131,
147
]
} |
administration of the hormone markedly affected maternal and fetal weight gain , fetal lung : body weight ratio and lipoprotein lipase activity of the lung . | NA | {
"id": "C0751992",
"name": "fetal weight",
"pos": [
61,
73
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
94,
105
]
} |
no difference was observed in pituitary gonadotrophins or serum lh in the neonatal males and females on days , 1 , 6 and 13 . | NA | {
"id": "C0018066",
"name": "pituitary gonadotrophins",
"pos": [
30,
54
]
} | {
"id": "C0023607",
"name": "lh",
"pos": [
64,
66
]
} |
urinary samples were fractionated by means of gel filtration and anion exchange chromatography to yield ( i ) fraction i consisting of basic , neutral , or slightly acidic glycopeptides and/or oligosaccharides , ( ii ) fraction ii consisting of acidic glycopeptides and/or oligosaccharides , and ( iii ) fraction iii con... | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
65,
70
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
374,
375
]
} |
contrary to a previous report , we found no evidence for the presence of an abnormally elevated rhamnose-containing glycoprotein or glycoconjugate in fraction ii . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
116,
128
]
} | {
"id": "C0017906",
"name": "glycoconjugate",
"pos": [
132,
146
]
} |
the kindling model of experimental epilepsy is characterized by a persistent seizure pattern and long-lasting seizure susceptibility without associated tissue damage . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
35,
43
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
110,
117
]
} |
also , the media may be designed to be selective with regard to cell type , so that fibroblastic overgrowth of primary cultures of epithelial cells can be avoided . | NA | {
"id": "C0007634",
"name": "cell type",
"pos": [
64,
73
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
84,
96
]
} |
the theory treats two types of rotational diffusion of membrane proteins : one is rotation of the whole protein about the normal to the plane of the membrane , and the other is restricted wobbling of the whole or part of the protein molecule . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
55,
72
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
225,
232
]
} |
the feasibility of the method has been demonstrated in a study of the rotation of the fluorescent lipid probe , dil ( [ bis , -2- ( n-octadecyl-3,3-dimethyl-1-benzo [ b ] pyrrole ] -trimethincyanine iodide ) incorporated into membranes composed of distearoylphosphatidylcholine ( dspc ) or dipalmitoylphosphatidylcholine... | NA | {
"id": "C0000039",
"name": "dipalmitoylphosphatidylcholine",
"pos": [
290,
320
]
} | {
"id": "C1959616",
"name": "phosphatidylcholines",
"pos": [
419,
439
]
} |
individual endplates were micro-dissected from chicken fast-twitch muscle , and the molecular forms of acetylcholinesterase and of pseudocholinesterase therein , identified by their sedimentation coefficients , were analysed directly . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
103,
123
]
} | {
"id": "C0008429",
"name": "pseudocholinesterase",
"pos": [
131,
151
]
} |
the higher activity of hyoscine itself could also be due to the presence of the n-methyl group in the axial position , rather than equatorial as in hyoscyamine or atropine . | NA | {
"id": "C0596004",
"name": "hyoscyamine",
"pos": [
148,
159
]
} | {
"id": "C0004259",
"name": "atropine",
"pos": [
163,
171
]
} |
the different position of the n-methyl group may partly explain why the pka of hyoscine is 2 units lower than that of hyoscyamine or atropine . | NA | {
"id": "C0596004",
"name": "hyoscyamine",
"pos": [
118,
129
]
} | {
"id": "C0004259",
"name": "atropine",
"pos": [
133,
141
]
} |
1 the effects of three methylene analogues of adenosine 5'-triphosphate ( atp ) or 5'-diphosphate ( adp ) have been studied on insulin secretion from the isolated perfused pancreas of the rat : 5'-adenylmethylene diphosphonate or beta , gamma-methylene atp , adenosine 5'-alpha , beta-methylene triphosphate or alpha , b... | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
213,
226
]
} | {
"id": "C0066351",
"name": "methylene diphosphonate",
"pos": [
368,
391
]
} |
of the four with open neural tube defects without anencephaly , only one was detected by screening and confirmed after amniocentesis . | NA | {
"id": "C0027794",
"name": "neural tube defects",
"pos": [
22,
41
]
} | {
"id": "C0002902",
"name": "anencephaly",
"pos": [
50,
61
]
} |
this disappointing outcome was attributed to the poor predictive value of alpha-fetoprotein in detecting open neural tube defects ( anencephaly apart ) rather than to errors in its estimation or in assessment of fetal maturity by sonar scan . | NA | {
"id": "C0027794",
"name": "neural tube defects",
"pos": [
110,
129
]
} | {
"id": "C0002902",
"name": "anencephaly",
"pos": [
132,
143
]
} |
the pure opiate antagonists , naloxone and naltrexone ( 0.1-10 mg/kg ) , dose-dependently suppressed water intake of 24 h water-deprived rats upon subcutaneous administration ; | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
30,
38
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
43,
53
]
} |
in the choroid plexus , the ouabain-sensitive electron-dense reaction products of na+ , k+-atpase ( p-nppase ) were strongly positive in the microvilli and along the inner surface of microvilli , without showing any mg2+-atpase and ac activities , and all three enzymatic activities were positive along the basal plasmal... | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
91,
97
]
} | {
"id": "C0001477",
"name": "mg2",
"pos": [
216,
219
]
} |
in the ventricular ependyma , na+ , k+-atpase ( p-nppase ) activity was not found , and the reaction product of ac was observed on the apical plasmalemmas and those of mg2+-atpase along the basal plasmalemmas . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
39,
45
]
} | {
"id": "C0001477",
"name": "mg2",
"pos": [
168,
171
]
} |
genetic variations in midbrain dopamine cell number : parallel with differences in responses to dopaminergic agonists and in naturalistic behaviors mediated by central dopaminergic systems . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
31,
39
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
168,
180
]
} |
this difference in cell number and th activity in the midbrain dopaminergic systems are paralleled by differences in drug responses and behaviors which are dependent on the release of dopamine in midbrain dopaminergic system . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
63,
71
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
205,
217
]
} |
genetically determined differences in the number of midbrain dopaminergic cell bodies and in the relative density of innervation of da terminals in target fields and in th activity in the nigrostriatal and mesolimbic dopaminergic systems are paralleled by difference in behavioral responses mediated by release of dopami... | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
61,
73
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
314,
322
]
} |
the effects of unilateral sensory stimuli on dopamine ( da ) release from nerve terminals and dendrites of the two nigrostriatal dopaminergic pathways were estimated in halothane-anaesthetized cats without or with sagittal transections . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
45,
53
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
129,
141
]
} |
the presence of the two forms of enolase , neuron-specific enolase ( nse ) and non-neuronal enolase ( nne ) , have been examined in biopsy material of human neuroblastoma , ganglioneuroblastoma , ganglioneuroma and cultured neuroblastoma cells , after separation with ion exchange chromatography . | NA | {
"id": "C0206718",
"name": "ganglioneuroblastoma",
"pos": [
173,
193
]
} | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
224,
237
]
} |
the relative nse levels in the neuroblastoma tissues were found to be lower than in the histopathologically more differentiated forms of the tumour , i.e . ganglioneuroblastoma and ganglioneuroma . | NA | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
31,
44
]
} | {
"id": "C0206718",
"name": "ganglioneuroblastoma",
"pos": [
156,
176
]
} |
on the basis of this knowledge , it has been possible , 1 ) to demonstrate that the oligosaccharides and glycoasparagines accumulating in tissues and urines of patients with diseases characterized by a lack in lysosomal glycosidases originate from glycoprotein glycans incompletely catabolized ; | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
84,
100
]
} | {
"id": "C0032594",
"name": "glycans",
"pos": [
261,
268
]
} |
the authors conclude that the adenocarcinoma cells produced sc and secreted it into the bloodstream and that the binding of sc with polymeric iga resulted in the hypergammaglobulinemia of siga . | NA | {
"id": "C0036538",
"name": "sc",
"pos": [
60,
62
]
} | {
"id": "C0020838",
"name": "siga",
"pos": [
188,
192
]
} |
the authors ' findings suggest that the high serum levels of siga in cancer patients may be due to the production and secretion of sc by tumor cells themselves rather than the reabsorption of intraluminal siga into the circulation through a damaged epithelium . | NA | {
"id": "C0036538",
"name": "sc",
"pos": [
131,
133
]
} | {
"id": "C0020838",
"name": "siga",
"pos": [
205,
209
]
} |
two diphosphonates , ehdp ( disodium etidronate , or ethanehydroxy-diphosphonate ) and cl2mdp ( disodium clodronate , or dichloromethylene-diphosphonate ) were injected in various doses in six patients with one or multiple episodes of malignant hypercalcemia . | NA | {
"id": "C0086268",
"name": "ehdp",
"pos": [
21,
25
]
} | {
"id": "C0037507",
"name": "disodium etidronate",
"pos": [
28,
47
]
} |
two diphosphonates , ehdp ( disodium etidronate , or ethanehydroxy-diphosphonate ) and cl2mdp ( disodium clodronate , or dichloromethylene-diphosphonate ) were injected in various doses in six patients with one or multiple episodes of malignant hypercalcemia . | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
4,
17
]
} | {
"id": "C0012081",
"name": "dichloromethylene-diphosphonate",
"pos": [
121,
152
]
} |
the fact that the dicentric nature of this marker was not apparent with the conventional giemsa stain emphasizes the usefulness of the c-banding technique in defining the origin of this important cytogenetic marker . | NA | {
"id": "C0005516",
"name": "marker",
"pos": [
43,
49
]
} | {
"id": "C0017393",
"name": "origin",
"pos": [
171,
177
]
} |
there has been a lack of direct cytogenetic studies on lymphocytes in the chronic phase of chronic myelocytic leukemia ( cml ) . | NA | {
"id": "C0023474",
"name": "chronic phase",
"pos": [
74,
87
]
} | {
"id": "C0023473",
"name": "cml",
"pos": [
121,
124
]
} |
the information obtained suggests that abundant virus-free antigens may be of greater use than virion-associated antigens as a source of viral antigen to evaluate mammary tumor status . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
59,
67
]
} | {
"id": "C0003342",
"name": "viral antigen",
"pos": [
137,
150
]
} |
the na+-k+-atpase was a minor component of the total atpase of these membranes ( less than 30 % ) . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
4,
6
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
53,
59
]
} |
a set of characteristic dna restriction fragments is found in common among secondary foci derived from each tumor cell line dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
124,
127
]
} |
superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages -- induction by multiple nonphagocytic stimuli . | NA | {
"id": "C0038836",
"name": "superoxide anion",
"pos": [
0,
16
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
30,
38
]
} |
the fibroblast chemoattractant property of fibronectin is retained in the proteolytically produced 160 kilodalton peptide that contains the heparin binding and cell binding domains of the molecule , while the 40 kilodalton collagen binding peptide is inactive . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
4,
14
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
160,
164
]
} |
kinetic studies with brush border sucrase revealed that augmentation of enzyme activity in pesticide-fed animals was due to an increase in the disaccharidase content . | NA | {
"id": "C0038634",
"name": "sucrase",
"pos": [
34,
41
]
} | {
"id": "C0012610",
"name": "disaccharidase",
"pos": [
143,
157
]
} |
the effect of replacement of hydrogen with deuterium at the positions alpha and beta to the nitroso function on carcinogenic potency was examined by administering by gavage the respective isotopically labeled compounds to groups of 20 male hamsters . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
29,
37
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
43,
52
]
} |
at equal dose levels of n-acetyl-2-aminofluorene , liver dna of sprague dawley rats contained 1/3 of the amount of n- ( guanin-8-yl ) -2-aminofluorene and 1/2 of the amount of n- ( guanin-8-yl ) -n-acetyl-2-aminofluorene present in liver dna of the r-amsterdam strain . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
57,
60
]
} | {
"id": "C0012933",
"name": "dna",
"pos": [
238,
241
]
} |
therapeutic concentrations of ampicillin , carbenicillin , penicillin , oxacillin , nafcillin , chloramphenicol , cephalothin , and methicillin in blood do not interfere , nor do triglycerides up to 10 g/l . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
59,
69
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
72,
81
]
} |
therapeutic concentrations of ampicillin , carbenicillin , penicillin , oxacillin , nafcillin , chloramphenicol , cephalothin , and methicillin in blood do not interfere , nor do triglycerides up to 10 g/l . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
59,
69
]
} | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
84,
93
]
} |
therapeutic concentrations of ampicillin , carbenicillin , penicillin , oxacillin , nafcillin , chloramphenicol , cephalothin , and methicillin in blood do not interfere , nor do triglycerides up to 10 g/l . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
59,
69
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
132,
143
]
} |
lipid-bound sialic acid was increased in more patients with leukemias , lymphomas , hodgkin 's disease , and melanomas , suggesting that it may be a useful biochemical marker in these types of cancer . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
72,
81
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
84,
102
]
} |
the major chemical components -- protein , phosphorus , cholesterol and sialic acid -- are increased uniformly , as are all polypeptides visible on gel electrophoresis patterns of xerocyte membranes . | NA | {
"id": "C0013879",
"name": "chemical",
"pos": [
10,
18
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
43,
53
]
} |
lipid peroxide levels and lipids content of serum lipoprotein fractions of pregnant subjects with or without pre-eclampsia . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
26,
32
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
50,
61
]
} |
a description is given of the different cytological patterns in smears of fine-needle aspirates for clinical thyroid diseases , such as simple and toxic goitre , different types of thyroiditis ( acute , subacute and chronic ) as well as the various differentiated thyroid neoplasms ( follicular , papillary , medullary )... | NA | {
"id": "C0040128",
"name": "thyroid diseases",
"pos": [
109,
125
]
} | {
"id": "C0040147",
"name": "thyroiditis",
"pos": [
181,
192
]
} |
from these observations it was concluded that cmc without fc mu receptors were either stimulated t mu cells or precursor t mu cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
102,
107
]
} | {
"id": "C0018956",
"name": "precursor",
"pos": [
111,
120
]
} |
c-reactive protein ( crp ) is an acute-phase reactant which has been found deposited at sites of inflammation and tissue destruction . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
0,
18
]
} | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
33,
53
]
} |
the simultaneous injection of rat red blood cells and allogeneic spleen cells induced an early and vigorous autoantibody response in athymic nude mice as well as in euthymic control mice . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
54,
64
]
} |
two main subfamilies are emerging , the interstitial , fibrillar collagens ( types i , ii and iii ) and the cell-associated or basement membrane collagens ( types iv and v ) . | NA | {
"id": "C0969669",
"name": "fibrillar collagens",
"pos": [
55,
74
]
} | {
"id": "C0009325",
"name": "collagens",
"pos": [
145,
154
]
} |
arterial blood samples were drawn during the control period and at the end of each period of dopamine infusion for the measurement of plasma dopamine , noradrenaline , adrenaline , renin , angiotensin ii , aldosterone , vasopressin , electrolytes and packed cell volume . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
152,
165
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
168,
178
]
} |
however , the slope on low sodium plus captopril did not increase to the level of subjects on a high-sodium diet , suggesting that factors in addition to the circulating ang ii level are also important in regulating the vascular responsiveness to ang ii . | NA | {
"id": "C0003018",
"name": "ang ii",
"pos": [
170,
176
]
} | {
"id": "C0003009",
"name": "ang ii",
"pos": [
247,
253
]
} |
standards of noradrenaline and adrenaline are added to the latter portions and are thus converted into standards of [ 14c ] metadrenalines . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
13,
26
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
127,
137
]
} |
the 3h/14c ratio is constant in each assay for a given catecholamine concentration and is determined for samples to which standards of noradrenaline and adrenaline are added to the 3h- ( as well as the 14c- ) labelled portions before the initial incubation . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
135,
148
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
153,
163
]
} |
the coefficients of variation are 3.0 and 3.2 % for noradrenaline and adrenaline respectively ( intra-assay ) and 4.6 and 5.0 % ( inter-assay ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
52,
65
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
70,
80
]
} |
most of the application programs are related to experimental work in a dna sequencing laboratory : search for overlapping dna fragments to construct complete dna sequences ; | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
69,
74
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
158,
161
]
} |
women with lpps were more likely to have their pregnancies confirmed and/or terminated in the second trimester than were women with tsfs . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
47,
58
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
94,
110
]
} |
in accord with the pigmentation theory , young california negroid children had less accurate short-wavelength color perception than california caucasoid children . | NA | {
"id": "C0728836",
"name": "young",
"pos": [
41,
46
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
153,
161
]
} |
we investigated suppressor cell activity in the peripheral blood of 39 patients with inflammatory bowel disease ( 30 crohn 's disease and 9 ulcerative colitis ) by the short-lived suppressor cell assay . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
85,
111
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
117,
133
]
} |
twenty-four adult patients receiving intravenous aminoglycosides ( gentamicin , netilmicin , or tobramycin ) had urine and serum collected for creatinine clearance calculations and had blood obtained for peak and through aminoglycoside concentration determinations . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
67,
77
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
221,
235
]
} |
in the 4 clinical trials comparing cefoperazone with cefamandole , cephazolin or carbenicillin , cefoperazone therapy resulted in a similar or higher rate of satisfactory clinical response . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
53,
64
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
97,
109
]
} |
pyridoxal-5'-phosphate , an inhibitor of dna binding of glucocorticoid- , progesterone- , and estrogen-receptor complexes , also blocks the interaction of mouse uterine cytosol estradiol-receptor complexes with oligodeoxynucleotides covalently linked to celluloses . | NA | {
"id": "C0034804",
"name": "estrogen-receptor",
"pos": [
94,
111
]
} | {
"id": "C0034803",
"name": "estradiol-receptor",
"pos": [
177,
195
]
} |
experiments with three oligodeoxynucleotides showed a 4-fold range of differences in the pyridoxal-5'-phosphate concentrations needed to inhibit 50 % of the binding : oligo ( dg ) -cellulose , 3.1 mm ; | NA | {
"id": "C0028948",
"name": "oligodeoxynucleotides",
"pos": [
23,
44
]
} | {
"id": "C0028953",
"name": "oligo",
"pos": [
167,
172
]
} |
hormonal responsiveness of the sertoli cell adenylyl cyclase of mature animals could be restored , however , either by addition of the nonmetabolizable guanosine 5'-triphosphate analog , 5'-guanylyl-imidodiphosphate to homogenates or by preparation of membrane particles . | NA | {
"id": "C0018353",
"name": "guanosine",
"pos": [
152,
161
]
} | {
"id": "C0018366",
"name": "guanylyl-imidodiphosphate",
"pos": [
190,
215
]
} |
escherichia coli k12 contains two phosphofructokinases : phosphofructokinase 1 , the most studied one , appears to behave as an allosteric enzyme , while phosphofructokinase 2 presents the features of a michaelian enzyme . | NA | {
"id": "C0162449",
"name": "phosphofructokinases",
"pos": [
34,
54
]
} | {
"id": "C0031651",
"name": "phosphofructokinase 1",
"pos": [
57,
78
]
} |
escherichia coli k12 contains two phosphofructokinases : phosphofructokinase 1 , the most studied one , appears to behave as an allosteric enzyme , while phosphofructokinase 2 presents the features of a michaelian enzyme . | NA | {
"id": "C0162449",
"name": "phosphofructokinases",
"pos": [
34,
54
]
} | {
"id": "C0049700",
"name": "phosphofructokinase 2",
"pos": [
154,
175
]
} |
kinetic deuterium isotope effects of between 2 and 3 were measured when the urocanase reaction was conducted in deuterium oxide at different p2h values . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
8,
17
]
} | {
"id": "C0011745",
"name": "deuterium oxide",
"pos": [
112,
127
]
} |
the specificity studies indicate that the enzyme is a `` '' post-proline cleaving enzyme '' '' which hydrolyzes peptides of the general structure , yaa-pro-xaa , in which xaa = amino acid , peptide , or amide ( not pro ) , and yaa = n-blocked basic amino acid or a peptide sequence in which the c-terminal residue ( i.e ... | NA | {
"id": "C0002520",
"name": "= amino ac",
"pos": [
175,
185
]
} | {
"id": "C0301714",
"name": "a basic amino ac",
"pos": [
352,
368
]
} |
the specificity studies indicate that the enzyme is a `` '' post-proline cleaving enzyme '' '' which hydrolyzes peptides of the general structure , yaa-pro-xaa , in which xaa = amino acid , peptide , or amide ( not pro ) , and yaa = n-blocked basic amino acid or a peptide sequence in which the c-terminal residue ( i.e ... | NA | {
"id": "C0301714",
"name": "a basic amino ac",
"pos": [
352,
368
]
} | {
"id": "C0024337",
"name": ", l",
"pos": [
383,
386
]
} |
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