text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
most frequent is a ventricular septal defect , followed by atrial septal defect , patent ductus arteriosus , patent foramen ovale , and coarctation of the aorta . | NA | {
"id": "C0018817",
"name": "atrial septal defect",
"pos": [
59,
79
]
} | {
"id": "C0016522",
"name": "patent foramen ovale",
"pos": [
109,
129
]
} |
prolactin ( hprl ) , growth hormone ( hgh ) , luteotropin ( lh ) , progesterone ( pg ) , and estradiol ( e2 ) were estimated ( mean +/- standard error ) along the menstrual cycles in the normal volunteers . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
21,
35
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
38,
41
]
} |
this finding , considered together with earlier reports of viral-like syndromes accompanying the disease , supports the implication of a respiratory virus as a possible etiologic factor . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
70,
79
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
97,
104
]
} |
while granulocytic sarcoma is a variant of granulocytic leukemia , the tumor may appear before , after , or concomitantly with hematologic evidence of leukemia . | NA | {
"id": "C0152276",
"name": "granulocytic sarcoma",
"pos": [
6,
26
]
} | {
"id": "C0023470",
"name": "granulocytic leukemia",
"pos": [
43,
64
]
} |
resting anion conductance ( ganion ) , assumed to be the sum of c1- and i- conductances , of fibers from iodide-treated pigeons decreased nonlinearly from 2,565 to 266 mumho/cm2 when the bath concentration of i- was increased from 0 to 120 mm . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
8,
13
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
216,
217
]
} |
the ability of ketone bodies to pass the blood-brain barrier was estimated by single common carotid injections of labeled ketone bodies and water , and results were expressed as the ratio between the normalized activities of tracers in tissue and blood , the brain uptake index ( bui ) . | NA | {
"id": "C0022631",
"name": "ketone bodies",
"pos": [
15,
28
]
} | {
"id": "C0022634",
"name": "ketone",
"pos": [
122,
128
]
} |
eighty-eight ( 63 per cent ) were malignant and included twenty-eight adenocarcinomas ( 31.8 per cent ) , twenty-four lymphosarcomas ( 27.3 per cent ) , nineteen carcinoids ( 21.6 per cent ) , and ten leiomyosarcomas ( 11.4 per cent ) . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
70,
85
]
} | {
"id": "C0007095",
"name": "carcinoids",
"pos": [
162,
172
]
} |
electrophoretic behavior of protein dodecyl sulfate complexes in the presence of various amounts of sodium dodecyl sulfate . | NA | {
"id": "C0058632",
"name": "dodecyl sulfate",
"pos": [
36,
51
]
} | {
"id": "C0037506",
"name": "sodium dodecyl sulfate",
"pos": [
100,
122
]
} |
( b ) decrease in the a-b , g2 , k , i1 , o2 , o3 , p , q , t1 , y2 , a ' , b ' , e ' 2 , e ' 3 , i ' , k ' , o'-l'-v-l and m2 factors , but ( c ) no change in the specifity or in the titre of the remaining 16 different blood factors . | NA | {
"id": "C0030054",
"name": "o2",
"pos": [
42,
44
]
} | {
"id": "C0030106",
"name": "o3",
"pos": [
47,
49
]
} |
further studies in allergenic identity between house dust and the house dust mite , dermatophagoides farinae hughes , 1961 . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
19,
29
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
66,
76
]
} |
the sera from 99 japanese asthmatic subjects were studied for the allergenic similarity between house dust and the house-dust mite , dermatophagoides farinae hughes , 1961 . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
66,
76
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
96,
106
]
} |
high correlation was not noted between house dust and other allergens such as smoky brown cockroach , periplaneta fuliginosa , aspergillus , book lice , liposcelis bostricophilus , cheyletus malaccensis and tribolium confusum . | NA | {
"id": "C0524581",
"name": "house dust",
"pos": [
39,
49
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
60,
69
]
} |
these results further support the view that the mite is the most important allergenic component in house dust . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
75,
85
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
99,
109
]
} |
the serum lipoprotein fractions from 5 morgan and 5 thoroughbred horses were isolated by preparative ultracentrifugation , chemically analyzed for lipid composition , and studied by 2 methods of polyacrylamide gel electrophoresis to determine electrophoretic mobility . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
10,
21
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
147,
152
]
} |
the secretion is insoluble in ethanol ether or chloroform methanol , suggesting that there is little lipid contained in it . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
30,
37
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
58,
66
]
} |
the subjects were classified as suffering from kartagener 's syndrome ( situs inversus , chronic sinusitis , and bronchiectasis ) and were shown to have an extremely slow , probably absent transport . | NA | {
"id": "C0022521",
"name": "kartagener 's syndrome",
"pos": [
47,
69
]
} | {
"id": "C0006267",
"name": "bronchiectasis",
"pos": [
113,
127
]
} |
a patient had systemic mastocytosis of 16 years ' duration , with urticaria pigmentosa , osteopetrosis with severe bone pain , mastocytosis of the bone marrow with myeloid metaplasia , gastrointestinal malabsorption , and cushingold features associated with prolonged usage of corticosteroids . | NA | {
"id": "C0221013",
"name": "systemic mastocytosis",
"pos": [
14,
35
]
} | {
"id": "C0024899",
"name": "mastocytosis",
"pos": [
127,
139
]
} |
with other patients , after initial treatment with depo-medroxyprogesterone acetate intramuscularly , we started using contraception pills containing medroxyprogesterone ; | NA | {
"id": "C0065864",
"name": "depo-medroxyprogesterone acetate",
"pos": [
51,
83
]
} | {
"id": "C0025147",
"name": "medroxyprogesterone",
"pos": [
150,
169
]
} |
these sensitive and resistant strains biosynthetize only one beta-lactamase which appears to be a cephalosporinase of the class id of richmond and sykes ( 1973 ) . | NA | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
61,
75
]
} | {
"id": "C0728805",
"name": "cephalosporinase",
"pos": [
98,
114
]
} |
when the animals were weaned to an ascorbic-acid-deficient diet signs of scurvy appeared earlier in the pups from the high vitamin c group and their survival was shorter . | NA | {
"id": "C0003969",
"name": "ascorbic-acid-deficient",
"pos": [
35,
58
]
} | {
"id": "C0036474",
"name": "scurvy",
"pos": [
73,
79
]
} |
as part of a continuing study on the loss or retention of enzymes involved in specific hepatic functions in a series of rat liver neoplasms ranging widely in growth rate and degree of differentiation , isozyme patterns of glycogen phosphorylase in rat hepatomas were compared with those in rat tissues during development... | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
58,
65
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
202,
209
]
} |
comparative analysis of urinary 3-o methyldopamine and the two other methoxylated amines ( norepinephrine and metanephrine ) shows that the methoxylated derivative of dopamine , when compared to normal subjects values , increased at the greatest extent in sympathoblastoma , while in ganglioneurona and chromaffin tumour... | NA | {
"id": "C0011498",
"name": "methyldopamine",
"pos": [
36,
50
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
167,
175
]
} |
comparative analysis of urinary 3-o methyldopamine and the two other methoxylated amines ( norepinephrine and metanephrine ) shows that the methoxylated derivative of dopamine , when compared to normal subjects values , increased at the greatest extent in sympathoblastoma , while in ganglioneurona and chromaffin tumour... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
91,
105
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
324,
339
]
} |
extracts were assayed for adenosine 5'-triphosphate ( atp ) , adenosine 5'-diphosphate ( adp ) , and adenosine 5'-monophosphate ( amp ) by the firefly method using an improved procedure . | NA | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
26,
37
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
101,
112
]
} |
extracts were assayed for adenosine 5'-triphosphate ( atp ) , adenosine 5'-diphosphate ( adp ) , and adenosine 5'-monophosphate ( amp ) by the firefly method using an improved procedure . | NA | {
"id": "C0001459",
"name": "adenosine 5",
"pos": [
26,
37
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
101,
112
]
} |
results indicated that extraction with trichloroacetic acid was the method most closely reflecting actual levels of atp , adp and amp in intact bacterial cells . | NA | {
"id": "C0001480",
"name": "atp",
"pos": [
116,
119
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
130,
133
]
} |
results indicated that extraction with trichloroacetic acid was the method most closely reflecting actual levels of atp , adp and amp in intact bacterial cells . | NA | {
"id": "C0001459",
"name": "adp",
"pos": [
122,
125
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
130,
133
]
} |
during an investigation of the effect of basic and acidic proteins on the growth of thermophilic aerobic sporeformers , crystalline egg albumin was found to be strongly bactericidal . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
58,
66
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
136,
143
]
} |
a complex of cysteine , iron , and nitric oxide was detected in the autoclaved solution of cysteine , ferrous sulfate , and sodium nitrite ; | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
24,
28
]
} | {
"id": "C0060282",
"name": "ferrous",
"pos": [
102,
109
]
} |
she had a combination of three types of hypersensitivity to chlorpromazine , ie , allergic contact dermatitis , photocontact dermatitis , and immediate allergic photosensitivity . | NA | {
"id": "C0162820",
"name": "allergic contact dermatitis",
"pos": [
82,
109
]
} | {
"id": "C0162824",
"name": "photocontact dermatitis",
"pos": [
112,
135
]
} |
the ratio of hva to vma output was higher in these infants than in adults , suggesting a more rapid turnover of dopamine than adrenaline and noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
126,
136
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
141,
154
]
} |
in order to study the occurrence and frequency of ischemia-induced ventricular arrhythmias , we analyzed 105 episodes of spontaneous angina pectoris occurring at rest in 28 hospitalized patients with unstable angina pectoris and proved coronary artery disease . | NA | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
133,
148
]
} | {
"id": "C0002965",
"name": "unstable angina pectoris",
"pos": [
200,
224
]
} |
lower than normal values were seen in septic shock and bacterial endocarditis , and normal results were seen in most other bacterial infections . | NA | {
"id": "C0014121",
"name": "bacterial endocarditis",
"pos": [
55,
77
]
} | {
"id": "C0004623",
"name": "bacterial infections",
"pos": [
123,
143
]
} |
the possible mediation of the neurohypophysial hormone , vasotocin , in the syndhronous rise in plasma gh and ffa , is suggested . | NA | {
"id": "C0032017",
"name": "neurohypophysial hormone",
"pos": [
30,
54
]
} | {
"id": "C0042418",
"name": "vasotocin",
"pos": [
57,
66
]
} |
whereas feed restriction caused a lowering of the liver glycogen concentration in both treatment groups , muscle glycogen levels were higher than in quail fed ad libitum . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
50,
64
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
113,
121
]
} |
isopropanol administration ( 3 g/kg , p.o . ) determines in the rat liver an inhibition of fatty acid oxidation , an enhancement of fatty acid esterification into triacylglycerols as well as an inhibition of lipoprotein secretion which appears to be related to alterations in hepatic phospholipids and which differentiat... | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
0,
11
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
340,
347
]
} |
total nucleic acid , total protein , rna , dna , and amino acid nitrogen contents were determined , as well as got and gpt activities and weight of the organ . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
6,
18
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
43,
46
]
} |
cost , ethical considerations , and practical difficulties in obtaining blood specimens from a large group of children suggested the need for a questionnaire method used with young children and completed by parents . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
110,
118
]
} | {
"id": "C0728836",
"name": "young children",
"pos": [
175,
189
]
} |
antigenicity of spontaneous tumour and its immunologic relationship with the organism are probably associated with antigens of cellular origin occurring on cell membrane as a result of malignization rather than with antigens induced by an etiological agent . | NA | {
"id": "C0003335",
"name": "antigenicity",
"pos": [
0,
12
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
216,
224
]
} |
the use of propoxyphene napsylate ( darvon-n ) contributed to the deaths of 4 persons , 3 of whom were former heroin addicts receiving large amounts of this drug in connection with propoxyphene substitution programs . | NA | {
"id": "C0033495",
"name": "propoxyphene",
"pos": [
11,
23
]
} | {
"id": "C0033493",
"name": "propoxyphene",
"pos": [
181,
193
]
} |
pathological conditions found on post mortem examination are summarised , while disease conditions such as anaemia , keratoconjuctivitis , toxoplasmosis , cryptococcocis , reproductive disorders , miscellaneous conditions and internal and external parasites are mentioned . | NA | {
"id": "C0030660",
"name": "pathological conditions",
"pos": [
0,
23
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
185,
194
]
} |
glycogen infiltration of tissues such as the heart and white skeletal muscle suggests that the round heart syndrome may be a manifestation of the glycogen storage disease , idiopathic generalized glycogenosis . | NA | {
"id": "C0017919",
"name": "glycogen storage disease",
"pos": [
146,
170
]
} | {
"id": "C0017921",
"name": "generalized glycogenosis",
"pos": [
184,
208
]
} |
the alpha-galactosidase a from all of the patients and controls has the same apparent km value for the synthetic substrate 4-methylumbelliferyl-alpha-galactosidase a , while the fifth has a thermolabile enzyme like that from the controls . | NA | {
"id": "C0002268",
"name": "alpha-galactosidase",
"pos": [
4,
23
]
} | {
"id": "C0016955",
"name": "galactosidase",
"pos": [
150,
163
]
} |
instead , the reading was position dependent and brnzimidazole is recognized ( 1 ) in the first codon position as adenine , ( 2 ) in the second as purine , and ( 3 ) in the third possibly only as base . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
114,
121
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
147,
153
]
} |
the amphilic amines , mepyramine , fenfluramine , norfenfluramine , hydroxyethylnorfenfluramine , n- ( 2-benzoyloxyethyl ) norfenfluramine , cinchocaine , chlorpromazine and demethylimipramine inhibited phosphatidate phosphohydrolase by 50 % at concentrations between 0.2 and 0.9 mm . | NA | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
35,
47
]
} | {
"id": "C0028362",
"name": "norfenfluramine",
"pos": [
123,
138
]
} |
amphilic cations which produced these effects included , in order of decreasing effectiveness , trifluoperazine ( half-maximal effect at about 70 mum ) greater than chlorpromazine approximately promethazine approximately imipramine greater than cinchocaine greater than amethocaine approximately cetyltrimethylammonium g... | NA | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
332,
344
]
} | {
"id": "C0031399",
"name": "phenethylamine",
"pos": [
385,
399
]
} |
it is likely that the essential lysine residue modified by pyridoxal 5'-phosphate is involved either in binding the coenzymes or in the catalytic step . | NA | {
"id": "C0034266",
"name": "pyridoxal 5",
"pos": [
59,
70
]
} | {
"id": "C0009235",
"name": "coenzymes",
"pos": [
116,
125
]
} |
a number of parameters affecting the adsorption of rrna and poly ( a ) -containing rna to millipore filters were investigated separately . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
51,
55
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
83,
86
]
} |
the binding of poly ( a ) -containing rna to the filter exhibited a broad ph-dependence compared with that of rrna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
38,
41
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
110,
114
]
} |
the ratio of poly ( a ) -rich rna/rrna retained by the filter was maximal between ph7 and 8 . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
30,
33
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
34,
38
]
} |
the amount of poly ( a ) -containing rna in the nucleus and in the cytoplasm of a plasmacytoma cell line ( mpc-11 ) labelled with [ 32p ] pi was determined by the millipore-filter technique under conditions that minimized contamination by rrna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
37,
40
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
239,
243
]
} |
in long labelling and pulse-chase experiments , however , contamination of the filter by rrna of increasing specific radioactivity in the cytoplasm gave an erroneous value for poly ( a ) -containing rna by the millipore-filter technique . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
89,
93
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
199,
202
]
} |
( 17 800-19 000 ) of the soluble enzyme was confirmed by gel filtration and is unchanged by sonication of the dna-enzyme complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
33,
39
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
114,
128
]
} |
the reduction is only indirectly dependent on nadph , which is required for the regeneration of gsh from gssg . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
96,
99
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
105,
109
]
} |
regulation of citrate synthase activity in methylotrophs by reduced nicotinamide-adenine dinucleotide , adenine nucleotides and 2-oxoglutarate . | NA | {
"id": "C0027270",
"name": "nicotinamide-adenine dinucleotide",
"pos": [
68,
101
]
} | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
104,
123
]
} |
respiration-dependent and energy-independent transhydrogenase , and ca2+-activated atpase ( adenosine triphosphatase ) activities were similar in both strains . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
68,
71
]
} | {
"id": "C0001473",
"name": "adenosine",
"pos": [
92,
101
]
} |
the glyco-protein nature of the major external iodinated species of kb cells was confirmed by adsorption chromatography of these substances , dissolved in low concentrations of triton x-100 , on a lectin-sepharose column . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
10,
17
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
197,
203
]
} |
effect of lipoprotein on 3-hydroxy-3-methylglutaryl coenzyme a ( hmg coa ) reductase activity in rat liver cell culture : special suppressant effect of a lipoprotein isolated from hypercholesterolemic rat plasma . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
10,
21
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
210,
211
]
} |
reconstitution of an atp-dependent sodium pump with an atpase from electric eel and pure phospholipids . | NA | {
"id": "C0001479",
"name": "sodium pump",
"pos": [
35,
46
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
55,
61
]
} |
in concentrations of 1 x 10 ( -5 ) to 1 x 10 ( -3 ) g/ml , indapamide antagonised contractions of arterial and venous strips to angiotensin , epinephrine and norepinephrine revealing a direct vascular action . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
142,
153
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
158,
172
]
} |
the lipopolysaccharides ( endotoxins ) of invasive enteropathogenic bacteria do not possess the character of a primary pathogenicity factor but operate as a protective agent versus bactericidal mechanisms of the macroorganism and probably also as an agent toxic for the tissue . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
4,
23
]
} | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
26,
36
]
} |
in rats , the sleeping time induced by overdosage with eight steroid anesthetics -- alfathesin , 3- ( 3-oxo-17beta-hydroxy-19-nor-4-androsten-17alpha-yl ) -propionic acid-lactone ( sc-8109 ) , 21-hydroxy=5alpha-pregnane-3,20-dione ( p-234 ) , 4-pregnene-3,11,20-trione ( bio.66 ) , 17-hydroxy-3-oxo-4-androstene-17alpha-... | NA | {
"id": "C0038317",
"name": "steroid",
"pos": [
61,
68
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
412,
420
]
} |
in rats , the sleeping time induced by overdosage with eight steroid anesthetics -- alfathesin , 3- ( 3-oxo-17beta-hydroxy-19-nor-4-androsten-17alpha-yl ) -propionic acid-lactone ( sc-8109 ) , 21-hydroxy=5alpha-pregnane-3,20-dione ( p-234 ) , 4-pregnene-3,11,20-trione ( bio.66 ) , 17-hydroxy-3-oxo-4-androstene-17alpha-... | NA | {
"id": "C0022947",
"name": "lactone",
"pos": [
171,
178
]
} | {
"id": "C0037982",
"name": "spironolactone",
"pos": [
756,
770
]
} |
glycine or dl-alpha-alanine potentiated the chemotherapeutic action of 3,6-diaminoacridinium without increasing its toxicity when these amino acids were combined with it simultaneously . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
136,
147
]
} |
the protein binding properties of m were separately investigated with bovine albumin , human albumin and with human , rat , rabbit and dog plasma . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
77,
84
]
} | {
"id": "C0304925",
"name": "human albumin",
"pos": [
87,
100
]
} |
in anesthetized cats 2,4,7-triamino-6-phenyl-pteridine ( triamterene ) ( 5 mg/kg i.v . ) causes a short-lasting increase in blood pressure , a decrease in heart rate , whereas the contractility ( see article ) remains unchanged . | NA | {
"id": "C0033991",
"name": "pteridine",
"pos": [
45,
54
]
} | {
"id": "C0040869",
"name": "triamterene",
"pos": [
57,
68
]
} |
the ampicillin concentrations in serum , urine , kidney , urinary bladder , prostate gland , testis , muscle and skin from 64 urological patients with normal renal function were determined with the agar diffusion method after oral doses of 700 mg of the pivaloyloxymethyl ester of ampicillin ( pivampicillin , pondocilli... | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
4,
14
]
} | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
294,
307
]
} |
analysis of individual lipoproteins separated by ultracentrifugation showed that newly secreted triglycerides were present almost exclusively in the very low density lipoprotein fraction . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
23,
35
]
} | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
149,
177
]
} |
the aortic endothelium of rabbits fed a stock diet containing 1 or 2 % cholesterol for intervals of 1 day to 21 weeks was compared with that of normal rabbits on a stock diet without cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
71,
82
]
} | {
"id": "C0008395",
"name": "diet",
"pos": [
170,
174
]
} |
it is suggested that insulin might be required for atherogenesis in addition to hyperlipemia and hypercholesterolemia . | NA | {
"id": "C0020473",
"name": "hyperlipemia",
"pos": [
80,
92
]
} | {
"id": "C0020443",
"name": "hypercholesterolemia",
"pos": [
97,
117
]
} |
constant infusions of heparin of 4 to 6 hours ' duration were used to estimate the transfer of very low density lipoprotein constituents to other plasma lipoproteins . | NA | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
95,
123
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
153,
165
]
} |
[ utilization of the anterior leaflet of the rectus abdominis sheath for abdominal wall repair . a propos of 865 operations for hernia and incisional hernia ( author 's transl ) ] . | NA | {
"id": "C0019270",
"name": "hernia",
"pos": [
128,
134
]
} | {
"id": "C0267716",
"name": "incisional",
"pos": [
139,
149
]
} |
hydrolysis of triglycerides via di- and mono-glycerides has been obtained from washed cells and crude lipolytic enzyme from staphylococcus aureus and candida lipolytica . | NA | {
"id": "C0041004",
"name": "triglycerides",
"pos": [
14,
27
]
} | {
"id": "C0017860",
"name": "glycerides",
"pos": [
45,
55
]
} |
[ studies on the adaptation of various strains of orthomyxovirus type a , subtype a/equi 2 , passaged either on bovine kidney cells or on chicken fibroblasts or on rk-13 cells or by those passages alternating with `` '' in ovo '' '' passages ] . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
146,
157
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
170,
175
]
} |
it is postulated that the enzyme deficiency of homozygous gunn rats influences the metabolism of analgesics to favour the excretion of nephrotoxic metabolites . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
83,
93
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
122,
131
]
} |
the facts are not a proof of the existence of an obligatory link between megalocytosis and carcinogenesis since a slight megalocytosis was observed in the riboflavin group not affected by the neoplastic process . | NA | {
"id": "C0596263",
"name": "carcinogenesis",
"pos": [
91,
105
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
192,
210
]
} |
current ways of fractionating immune sera give rise in the guinea-pig species to an active plasmin that contaminates antibody preparations . | NA | {
"id": "C0020960",
"name": "immune sera",
"pos": [
30,
41
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
117,
125
]
} |
six weeks after delivery , the clotting factors were similar to the control values in those who had received stilboestrol but factor ii was still raised in the quinestrol treated patients . | NA | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
31,
47
]
} | {
"id": "C0033706",
"name": "factor ii",
"pos": [
126,
135
]
} |
isolated extrasystoles were common , particularly in older patients , and sustained ectopic cardiac arrhythmias were observed in 4-6 per cent of patients of all ages . | NA | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
9,
22
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
100,
111
]
} |
acyl-protein , acyl-coa , free fatty acids and lipids were resolved from each other and analysed for their distribution of 14c-labelled fatty acids . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
26,
42
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
136,
147
]
} |
5 alpha-androstane and 5 alpha-pregnane are effective quenchers of albumin fluorescence , in accord with the essentially hydrophobic nature of the steroid-albumin interaction . | NA | {
"id": "C0033006",
"name": "pregnane",
"pos": [
31,
39
]
} | {
"id": "C0038317",
"name": "steroid",
"pos": [
147,
154
]
} |
maltohexaose producing amylase ( ec 3.2.1.- ) is the fourth known exo-amylase , the three previously known being glucoamylase , beta-amylase and pseudomonas stutzeri maltotetraose producing amylase . | NA | {
"id": "C0005194",
"name": "beta-amylase",
"pos": [
128,
140
]
} | {
"id": "C0002712",
"name": "amylase",
"pos": [
190,
197
]
} |
the enzyme after release from aerobacter aerogenes cells by 0.1 % sodium lauryl sulfate extraction was purified by ammonium sulfate precipitation , deae-sephadex column chromatography and sephadex g-100 gel filtration to 80-fold of the original sodium lauryl sulfate extract activity , it gave a single band on disc elec... | NA | {
"id": "C0058632",
"name": "lauryl sulfate",
"pos": [
73,
87
]
} | {
"id": "C0037506",
"name": "sodium lauryl sulfate",
"pos": [
245,
266
]
} |
this enzyme produced maltohexaose from starch , amylose and amylopectin by exo-attack , but did not act on alpha- or beta-cyclodextrin , pullulan or maltohexaitol . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
39,
45
]
} | {
"id": "C0002732",
"name": "amylose",
"pos": [
48,
55
]
} |
this enzyme produced maltohexaose from starch , amylose and amylopectin by exo-attack , but did not act on alpha- or beta-cyclodextrin , pullulan or maltohexaitol . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
39,
45
]
} | {
"id": "C0002728",
"name": "amylopectin",
"pos": [
60,
71
]
} |
they appear to be true aminopeptidases hydrolysing amino acid amides , dipeptides and oligopeptides from the n-terminal end . | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
71,
81
]
} | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
86,
99
]
} |
chromatographic studies with ( 14c ) purine-labeled dna indicate preferential binding of platinum to guanine , followed by binding to adenine . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
37,
43
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
134,
141
]
} |
although substantially less active than the guanine nucleotides , itp and the dialcohol derived from gtp by periodate oxidation and borohydride reduction ( ox-redgtp ) were partially active in both the if-2 and ef-tu-dependent reactions , with apparent km values about 40-100 times those of gtp . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
44,
63
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
291,
294
]
} |
the interaction of nuclear proteins of protamine and histone with neutral and charged blm was studied . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
19,
35
]
} | {
"id": "C0033603",
"name": "protamine",
"pos": [
39,
48
]
} |
the interaction of nuclear proteins of protamine and histone with neutral and charged blm was studied . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
19,
35
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
53,
60
]
} |
with an increase of the dimensions of penetrating ions the maximum cation selectivity reached in the beginning decreases with a further growth of cation radius . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
30,
34
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
146,
152
]
} |
the influence of catecholamines ( adrenaline and noradrenaline ) on energy metabolism of the rat myocardium has been studied by incubating slices of this tissue with these hormones and by following the levels of the different phosphorylated fractions and adenylic nucleotides . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
34,
44
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
49,
62
]
} |
the influence of catecholamines ( adrenaline and noradrenaline ) on 32pi incorporation into intracellular phosphate and adenylic nucleotides has been studied on rat myocardium slices ; | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
34,
44
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
49,
62
]
} |
it is found that hexammine cobaltichloride ( hac ) which interacts with anionic groups of sulphate-containing glycosamine glycanes , is a specific inhibitor of mitochondrial transport of ca2+ ( semi-maximal inhibition in the presence of 6 nmoles hac/mg of protein ) and sr2+ ( semi-maximal inhibition in the presence of ... | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
72,
79
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
90,
98
]
} |
specific trypsin substrates ( esters , anilides , amides , peptides ) were shown to accelerate deacetylation of monoacetylated trypsin . | NA | {
"id": "C0003035",
"name": "anilides",
"pos": [
39,
47
]
} | {
"id": "C0002482",
"name": "amides",
"pos": [
50,
56
]
} |
possible correlation between the increase in specific radioactivity of most nuclear histones under regeneration process and a migration of pre-synthesized labelled histone molecules into nucleus , and also a transformation into histones of other nuclear proteins is discussed . | NA | {
"id": "C0019652",
"name": "histones",
"pos": [
84,
92
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
246,
262
]
} |
the results obtained suggest that the activation of carbonic anhydrase in vivo by gastrin ( pentagastrin ) , histamine and 3',5'-amp is due to the phosphorylation of highly active isoenzyme by 3',5-amp-dependent protein kinase . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
82,
89
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
92,
104
]
} |
three different amino acids ( glycine , aspartic acid and leucine ) are found to follow the n-terminal amino acid which is indicative of a non-identity of its subunits . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
16,
27
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
30,
37
]
} |
it means that biosynthesis of some membrane proteins can be twice more resistant to the action of the antibiotic than the biosynthesis of other proteins , the total protein biosynthesis being significantly depressed ( the incorporation of labelled leucine in membrane proteins is inhibited by 78 % , and in cytoplasmic p... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
44,
52
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
259,
276
]
} |
the content of 4 fractions of nuclear proteins ( histones , acid chromatin protein , globulins and chromatin-free acid protein ) in diploid and polyploid hepatocytes from intact and regenerating liver of mice is studied . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
30,
46
]
} | {
"id": "C0019652",
"name": "histones",
"pos": [
49,
57
]
} |
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