text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
when first formed this layer strains readily with sudan b , but the lipid becomes incorporated in a delicate non-lipid silver-binding membrane ( also exuded from the epicuticular channels ) and hardens just before ecdysis , to form the so-called 'wax layer ' which then no longer stains with sudan b . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
68,
73
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
247,
250
]
} |
the mass ratio of nuclear non-histone protein : dna in the immature circulating erythroid cells of phenylhydrazine-induced anaemic xenopus is approximately threefold higher than in mature erythrocytes . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
18,
25
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
30,
37
]
} |
this hypothesis has been examined by a study of the kinetics of aggregation of dispersed populations of an invasive cell type ( the rabbit peritoneal neutrophil granulocyte ) and a host cell type ( the chick embryo heart fibroblast ) in shaken suspension culture . | NA | {
"id": "C0007634",
"name": "cell type",
"pos": [
116,
125
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
221,
231
]
} |
in four out of seven patients with primary hyperparathyroidism , we have found elevated plasma renin activity ( pra ) and blood pressure , both of which returned to normal following surgical correction of the hyperparathyroidism . | NA | {
"id": "C0221002",
"name": "primary hyperparathyroidism",
"pos": [
35,
62
]
} | {
"id": "C0020502",
"name": "hyperparathyroidism",
"pos": [
209,
228
]
} |
because many of the samples were at or below the sensitivity of the band iia assay , they were concentrated after extraction with either methanol or acid-ethanol . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
137,
145
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
154,
161
]
} |
samples were analyzed directly for total immunoreactive insulin ( tir ) and for insulin and proinsulin following plasma fractionation by gel filtration . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
56,
63
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
92,
102
]
} |
fractionation disclosed that most of the normal gestational increase in basal and glucose-stimulated tir can be ascribed to insulin rather than disproportionate increments in proinsulin-like components . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
124,
131
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
175,
185
]
} |
normal proinsulin/insulin relationships were also preserved in mild diabetics despite greater variability in their tir response to glucose . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
7,
17
]
} | {
"id": "C0021641",
"name": "tir",
"pos": [
115,
118
]
} |
in contrast basal proinsulin levels were elevated in 4 of 9 pregnant subjects with diabetes sufficiently severe to necessitate subsequent insulin therapy . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
18,
28
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
138,
145
]
} |
following glucose administration in the severe diabetics , the relative contribution from proinsulin to tir was altered so that ratios of circulating proinsulin/insulin were increased at all levels of blood sugar . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
90,
100
]
} | {
"id": "C0021641",
"name": "tir",
"pos": [
104,
107
]
} |
postpartum tests of glucose tolerance in some of the normal and mildly diabetic subjects confirmed that pregnancy per se does not modify appreciably the relationships between plasma insulin and proinsulin although there may be some tendency for proinsulin to account for a smaller proportion of tir . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
194,
204
]
} | {
"id": "C0021641",
"name": "tir",
"pos": [
295,
298
]
} |
these findings support the proposal that rickets and osteomalacia reported in patients on chronic anticonvulsant therapy results from reduced calcium absorption . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
41,
48
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
53,
65
]
} |
microscopically , early lesions were typified by localized bronchitis , bronchiolitis , alveolitis , and vasculitis with exuberant exudates containing predominantly polymorphonuclear leukocytes . | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
59,
69
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
72,
85
]
} |
thirteen matched patient pairs were treated by either nasal insufflation of cromolyn sodium powder , 20 mg three times daily , or by a placebo powder . | NA | {
"id": "C1272999",
"name": "nasal",
"pos": [
54,
59
]
} | {
"id": "C0032861",
"name": "powder",
"pos": [
143,
149
]
} |
patients with a history of old , well-compensated myocardial infarction , and those with cardiac arrhythmia , bundle-branch block , congestive heart failure and a-v block ( pacemaker-protected ) but no evidence of previous myocardial infarction fared almost as well as subjects of the same age without cardiac disease , ... | NA | {
"id": "C0003811",
"name": "cardiac",
"pos": [
89,
96
]
} | {
"id": "C0018799",
"name": "cardiac disease",
"pos": [
302,
317
]
} |
a direct competitive binding radioimmunoassay for dna has been developed , using 125i-iododeoxyuridine-labelled dna as the antigen and the serum from a patient with systemic lupus erythematosus . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
112,
115
]
} |
l-dopa ( 5 and 10 mg ) prevented the release of prolactin induced by suckling , but 1-25 and 2-5 mg l-dopa had no effect . | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
0,
6
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
102,
106
]
} |
the results indicate that the corticosteroids control both the release and the synthesis of acth but that their effect is predominantly on the release of the hormone . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
30,
45
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
158,
165
]
} |
growth of haploid yeast strains was inhibited by the phenylalanine ( pa ) analogue dl-p-fluorophenylalanine ( fpa ) in yeast extract media containing 0-2 mg pa/ml . | NA | {
"id": "C0030137",
"name": "p-fluorophenylalanine",
"pos": [
86,
107
]
} | {
"id": "C0031453",
"name": "pa",
"pos": [
157,
159
]
} |
fatty acids of medium chain length ( c6 to cii ) at 0-4 % produced a decrease in cell concentration , nonanoic and decanoic acids being the most effective . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
0,
11
]
} | {
"id": "C0011090",
"name": "decanoic acids",
"pos": [
115,
129
]
} |
simultaneous treatment of mouse cells with interferon and vitamin a ( retinoic acid ) resulted in an inhibition of interferon action . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
58,
67
]
} | {
"id": "C0040845",
"name": "retinoic",
"pos": [
70,
78
]
} |
retinyl acetate ( acetate ester of vitamin a ) and retinal ( vitamin a adehyde ) only slightly inhibited interferon activity , while retinoic acid ( vitamin a acid ) and retinol ( vitamin a alcohol ) were similarly effective at inhibiting interferon activity . | NA | {
"id": "C0073109",
"name": "acetate",
"pos": [
8,
15
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
180,
189
]
} |
retinyl acetate ( acetate ester of vitamin a ) and retinal ( vitamin a adehyde ) only slightly inhibited interferon activity , while retinoic acid ( vitamin a acid ) and retinol ( vitamin a alcohol ) were similarly effective at inhibiting interferon activity . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
35,
44
]
} | {
"id": "C0040845",
"name": "vitamin a acid",
"pos": [
149,
163
]
} |
the binding was sensitive to heat and sh-blocking reagents and displaceable by serotonin in excess , d-lsd , and to a lower extent by 5-methoxytryptamine and tryptamine . | NA | {
"id": "C0036751",
"name": "serotonin",
"pos": [
79,
88
]
} | {
"id": "C0000589",
"name": "5-methoxytryptamine",
"pos": [
134,
153
]
} |
results of immunological experiments with various human brain tumours show differences between astrocytoma and glioblastoma multiforme when brain-specific alpha2-glycoprotein is used as an immunological marker . | NA | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
95,
106
]
} | {
"id": "C0017636",
"name": "glioblastoma multiforme",
"pos": [
111,
134
]
} |
the 3 folate parameters were positively correlated with each other and negatively correlated with serum phenobarbitone , diphenylhydantoin and primidone . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
104,
118
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
143,
152
]
} |
a possible relationship between folate and monoamine metabolism is discussed with particular reference to the antiepileptic and toxic effects of phenobarbitone , diphenylhydantoin and primidone . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
145,
159
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
184,
193
]
} |
a hydroxylated metabolite of phenylbutazone ( oxyphenbutazone ) inhibited the elimination of phenytoin , which is metabolized by oxidative pathways . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
29,
43
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
46,
61
]
} |
the molecular connectivity index is shown to be linearly related to the octanol-water partition coefficients of a variety of monofunctional chemical classes including esters , alcohol , ketones , ethers , carboxylic acids , amines , and hydrocarbons . | NA | {
"id": "C0014898",
"name": "esters",
"pos": [
167,
173
]
} | {
"id": "C0007066",
"name": "carboxylic acids",
"pos": [
205,
221
]
} |
interest in 2,3-bis ( p-methoxyphenyl ) imidazo [ 1,2-a ] -pyrimidine as a potent , orally active , anti-inflammatory agent required a method for its determination in serum , urine , and feces to permit studies of its absorption , metabolism , and excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
231,
241
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
248,
257
]
} |
no significant difference was observed between lipid and lipoprotein levels in gout and avascular necrosis , although the serum uric acid was higher in the gouty patients . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
47,
52
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
57,
68
]
} |
in contrast to the findings in gout , the uric acid levels did not correlate with the lipid or lipoprotein fractions in patients with avascular necrosis . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
86,
91
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
95,
106
]
} |
there were no statistical differences between lipid , lipoprotein and uric acid levels in patients with avascular necrosis receiving corticosteroids or using alcohol , as compared with those not taking these drugs . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
46,
51
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
54,
65
]
} |
when solutions of nucleoside 5'-phosphates and trimetaphosphate are dried out at room temperature , nucleoside 5'-polyphosphates are formed . | NA | {
"id": "C0031603",
"name": "phosphates",
"pos": [
32,
42
]
} | {
"id": "C0032575",
"name": "polyphosphates",
"pos": [
114,
128
]
} |
most , if not all , mineral oil-induced pct cells carried pc1 antigen and produced many extracellular type-c viruses carrying xvea and x1-vea , whereas abelson 's tumor cells had both a lower incidence and a smaller amount of pc1 and x.1 antigens and xvea+ virus and lacked x1-vea+ virus . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
238,
246
]
} | {
"id": "C0003342",
"name": "vea",
"pos": [
277,
280
]
} |
a 30-mug dose of 3-methylcholanthrene ( mca ) was applied for 1 week to normal balb/c fibroblasts in cell-impermeable diffusion chambers ( dc ) in the peritoneal cavities of balb/c micemtwo groups of dc cultures , in which the carcinogen was given during weeks 1 and 5 of cultivation , respectively , were compared for t... | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
72,
78
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
86,
97
]
} |
a kinetic study of normal fibroblasts in dc revealed that cells proliferated rapidly , with a peak at day 4 after seeding , then grew progressively more slowly and ceased to replicate between 14 and 28 days of culture . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
26,
37
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
58,
63
]
} |
migration of peripheral leukocytes in samples from sensitized [ epstein-barr virus ( ebv ) antibody-positive ] humans was greatly inhibited when challenged by antigen prepared from ebv-producing p3hr-1 cells but not by antigen prepared from ebv-nonproducing raji cells , ebv-negative human fibroblasts , or epithelial ce... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
202,
207
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
290,
301
]
} |
the addition of conditioned medium from undifferentiated fibroblast-like cells brought about the reappearance of pigmented melanocytes and the increase of the metabolite in the cells and culture medium . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
57,
67
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
177,
182
]
} |
isolation and comparison of the dna ( s ) associated with cap and nuclei showed a higher specific activity for cap-associated dna than for nuclear dna , which was in good agreement with the autoradiographic analysis . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
32,
35
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
209,
210
]
} |
a method is described for analysis of viral protein synthesis early after infection when minute amounts of viral proteins are effectively concealed by large amounts of produced host-specific proteins . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
107,
121
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
191,
199
]
} |
hybridization between 3h-labeled 35s rna from rav-61 and normal pheasant dna was inhibited 100 % by homologous viral rna , 22 to 26 % by rna from amv or rav-0 , and 30 to 33 % by rna from rav-60 or b-77 . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
111,
120
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
179,
182
]
} |
it appears that different avian rna tumor virus genomes have from 50 to 80 % homology in nucleotide sequences and that the degree of hybridization between normal chicken cell dna and a given viral rna can be predicted from the homology that exists between the viral rna tested and rav-0 rna . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
191,
200
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
287,
290
]
} |
( iii ) competition of unlabeled viral rna in hybridization reactions between the radioactive rna from the two viruses and their respective proviral sequences present in tumor tissues showed that 15 to 20 % of the viral sequences detected in these reactions were unshared . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
33,
42
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
94,
97
]
} |
the transformed cell nuclear viral rna is complementary to 60 % of the e strand , whereas cytoplasmic rna is complementary to 40 % of the e strand and comprises the same polyoma-specific sequences as are found in rna early in productive infection . | NA | {
"id": "C0035700",
"name": "nuclear",
"pos": [
21,
28
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
213,
216
]
} |
synthesis of the vesicular stomatitis virus membrane matrix protein and the glycoprotein is inhibited to a greater extent than the synthesis of the nucleocapsid protein , the nonstructural protein , and the large protein when the rate of peptide chain initiation is reduced by exposure of vesicular stomatitis virus-infe... | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
44,
52
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
213,
220
]
} |
the results suggest specific mechanisms by which type c viral proteins can package type c viral rna and provide an approach to classifying rna of potentially defective endogenous retraviruses as type c in origin . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
90,
99
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
139,
142
]
} |
the spontaneous mutation of b77 virus type ii to b77 virus type iii occurs with a high rate ( approximately 1 mutation per 50 infected cell generations ) , requires cell replication , and neither occurs during the synthesis of viral dna on an rna template nor during the transcription of progeny viral rna from the provi... | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
243,
246
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
296,
305
]
} |
[ concepts and classification of hyperlipidemia and hyperlipoproteinemia with special reference to the classifications according to frederickson and who ] . | NA | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
33,
47
]
} | {
"id": "C0020476",
"name": "hyperlipoproteinemia",
"pos": [
52,
72
]
} |
the question of whether the coronary blood vessels contain an intrinsic adrenergic mechanism for vasodilatation of physiological significance has been examined in the canine heart-lung preparation with a donor by studying the response of the coronary vessels to epinephrine , norepinephrine , isoproterenol and salbutamo... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
262,
273
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
276,
290
]
} |
epinephrine and norepinephrine produced a decrease in the coronary flow after practolol which completely abolished the increase in the myocardial o2 consumption as well as the positive inotropic and chronotropic effects produced by these compounds , while isoproterenol and salbutamol produced an increase . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} |
the alteration of pulmonary function in 35 patients with abdominal trauma admitted to the trauma icu of oska university hospital were studied . | NA | {
"id": "C0848377",
"name": "abdominal trauma",
"pos": [
57,
73
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
90,
96
]
} |
the inotropic effect is equivalent to that of isoproterenol , epinephrine , and norepinephrine , but tachycardia , tachyarrhythmias , and angina may be less frequent with dopamine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
62,
73
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
80,
94
]
} |
in order to obtain data on the amount of sodium chloride used in the german federal republic , 106 persons of different social groups , with healthy kidneys , were investigated , measuring the sodium chloride contents in their 24-hour urine . | NA | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
41,
56
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
200,
208
]
} |
the sodium chloride intake follows from the sodium chloride secretion because the regulation of the sodium household is effected through the renal excretion , and with healthy people the daily intake of sodium chloride down to a limit value of 200 mval per day is eliminated without delay . | NA | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
4,
19
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
210,
218
]
} |
an increasing percentage of albumin was expressed in the albumin/globulin ratios of 0.72 , in a group of rats excreting a mean concentration of 1.91 mg/ml of protein in the urine , and 2.24 in a group of rats excreting , on the average , 17.62 mg/ml . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
28,
35
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
158,
165
]
} |
weight at birth averaged 20.2 +/- 0.3 g , or about 8 % ( litter about 16 % ) the weight of the adult . | NA | {
"id": "C0005612",
"name": "weight",
"pos": [
0,
6
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
81,
87
]
} |
a number of recent problems have been revealed and solved , or partly solved by this international effort , among which are questions relating to : the marburg agent disease , the existence of an antigenic relationship between rabies virus and some arboviruses , aspects of the ecology or viruses in the california , uuk... | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
196,
205
]
} | {
"id": "C0003342",
"name": "antigenic",
"pos": [
382,
391
]
} |
a morphometric evaluation of the soft tissue ( animal ) gave similar good results for stainless steel implants as for the combination of titanium and steel , while pure titanium gave the best result . | NA | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
86,
101
]
} | {
"id": "C0038239",
"name": "steel",
"pos": [
150,
155
]
} |
atomic absorption tests ( human ) showed that in case of the titanium/steel mixture only the stainless steel screws did corrode . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
70,
75
]
} | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
93,
108
]
} |
the role of radiotherapy and adjuvant chemotherapy in the primary treatment of osteogenic sarcomas and of ewing 's sarcoma is reviewed . | NA | {
"id": "C0029463",
"name": "osteogenic sarcomas",
"pos": [
79,
98
]
} | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
106,
122
]
} |
of the malignant bone tumors that occur in childhood , chondrosarcoma , osteosarcoma , and ewing 's sarcoma are of special interest with regard to therapeutic approach . | NA | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
72,
84
]
} | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
91,
107
]
} |
whereas in chondrosarcoma radical surgery is the treatment of choice , due to its resistance to radiation , the most efficient treatment for osteosarcoma and ewing 's sarcoma has not yet been clearly defined . | NA | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
141,
153
]
} | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
158,
174
]
} |
clearly , esterified lipids of liver and plasma lipoproteins ( very low density lipoprotein , low density lipoprotein , and high density lipoprotein ) , and to a lesser extent , adipose tissue , were enriched with 18:2 derived from dietary triglyceride fatty acid even 16 hr after the terminal meal . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
21,
27
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
48,
60
]
} |
clearly , esterified lipids of liver and plasma lipoproteins ( very low density lipoprotein , low density lipoprotein , and high density lipoprotein ) , and to a lesser extent , adipose tissue , were enriched with 18:2 derived from dietary triglyceride fatty acid even 16 hr after the terminal meal . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
48,
60
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
63,
79
]
} |
the very low density lipoprotein isolated from plasma of fat fed rats contained fewer moles of phospholipids , cholesterol , and cholesteryl esters , relative to triglyceride than did the very low density lipoprotein from plasma of animals not receiving safflower oil . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
111,
122
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
129,
147
]
} |
the molar ratio triglyceride : phospholipid : cholesterol : cholesterol esters in the very low denity lipoprotein was 100:42.0:22.1:44.5 in the control group and 100:35.4:17.8:19.5 in the fat fed animals . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
46,
57
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
60,
78
]
} |
the effect of ammonium ions on the activity of alcohol : nad- , l-malate : nad- , l-glutamate : nadp-oxidoreductases was studied in wine yeast during fermentation of wine wort containing 18 % of sugar , and also after the biomass cultivated in the conditions of nitrogen deficiency had been transferred to media with var... | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
47,
54
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
166,
170
]
} |
lipids of the most studied cultures were found to contain di- and triglycerides , waxes , free fatty acids , sterines , their esters , and phospholipids . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
0,
6
]
} | {
"id": "C0043076",
"name": "waxes",
"pos": [
82,
87
]
} |
a collection of 98 strains of enteric gramnegative bacteria isolated in routine investigations in a hospital laboratory all showed beta-lactamase activity , and 39 of them ( 40 % ) produced sufficient enzyme to allow determination of their relative activities against benzylpenicillin , ampicillin and cephaloridine ( su... | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
268,
284
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
287,
297
]
} |
seventeen patients treated for a mean period of 9-4 months with an enteric-coated form of l-dopa ( prodopa ) , obtained the usual spectrum of benefit as from conventional l-dopa . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
92,
96
]
} | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
171,
177
]
} |
a case of the rare coexistence of chronic lymphatic leukemia and a malignant lymphoma with cytological picture resembling that of hodgkin 's disease is described . | NA | {
"id": "C0024299",
"name": "malignant",
"pos": [
67,
76
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
130,
148
]
} |
by this method we have purified the following t7 replication-related proteins ( each greater than 50 % pure as judged by sodium dodecyl sulfate gel electrophoresis ) : t7 dna-binding protein ( 27,000 daltons ) , t7 rna polymerase ( 105,000 daltons ) , t7 dna polymerase ( gene 5-protein , 85,000 daltons , plus host-fact... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
69,
77
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
171,
190
]
} |
in the presence of t7 dna-binding protein and all four ribonucleoside triphosphates , the dna-priming protein enables t7 dna polymerase to initiate dna synthesis on intact duplex t7 dna . | NA | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
22,
41
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
102,
109
]
} |
dna synthesis in vitro using intact duplex t7 dna as template is dependent on a novel group of three phage t7-induced proteins : dna-priming protein ( activity which complements a cell extract lacking the t7 gene 4-protein ) , t7 dna polymerase ( gene 5-protein plus host factor ) , and t7 dna-binding protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
118,
125
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
290,
309
]
} |
some of the biological properties of saline extracts of the mycelia of several species of the aspergillus genus , namely , a. fumigatus , a. flavus , a. niger , a. nidulans , a. parasitucus and a. glaucus , were studied . | NA | {
"id": "C0004034",
"name": "aspergillus",
"pos": [
94,
105
]
} | {
"id": "C0004037",
"name": "fumigatus",
"pos": [
126,
135
]
} |
haemoglobins d-los angeles ( alpha2beta2 121 glu leads to gln ) and j-baltimore ( alpha2beta2 16 gly leads to asp ) in two dutch families . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
45,
48
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
58,
61
]
} |
in the same period 254 patients with head injuries were admitted here and 106 demonstrated skull fractures . | NA | {
"id": "C0018674",
"name": "head",
"pos": [
37,
41
]
} | {
"id": "C0037304",
"name": "skull fractures",
"pos": [
91,
106
]
} |
in vivo fluorine uptake in human enamel following treatment with a varnish containing sodium fluoride . | NA | {
"id": "C0016327",
"name": "fluorine",
"pos": [
8,
16
]
} | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
86,
101
]
} |
in five teeth ( group ii ) th f-uptake was determined one day after a single topical application of a varnish which contained 5 % naf ( duraphat ) , and compared with the corresponding control contralateral teeth . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
3,
4
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
130,
133
]
} |
four groups of rats were utilized : group i -- injected intraperitoneally at 6 days of age with 20 mg f/kg b.w . as sodium fluoride solution and terminated at 30 minutes and 1 , 5 and 9 days postinjection ; | NA | {
"id": "C0016327",
"name": "f",
"pos": [
0,
1
]
} | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
116,
131
]
} |
conventional fluoride application by mouthrinsing with neutral naf solution ( 0.025 % daily for three weeks or three months ; or 0.05 % solution daily ; or 0.2 % solution weekly for three weeks ) is found to result in only moderate and insignificant uptake of f in facial enamel surfaces . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
13,
21
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
63,
66
]
} |
painting , at one week 's interval for three weeks with 2 % naf ( ph=5 ) solution and application of an apf-gel ( flura-kerr 1.23 % f ) results in the significant uptake of a few hundred ppm f within the first 10 microns of the enamel . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
60,
63
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
222,
223
]
} |
painting with 2 % naf ( ph=7 ) , with 8 % snf2 , or with 5 % na2po3f solutions does not yield a significant gain in f in the first 10 microns of the facial enamel , as determined by the etching technique under similar conditions . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
18,
21
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
149,
150
]
} |
a varnish ( duraphat ) containing 5 % naf ( applied three times at weekly intervals ) is found to deposit considerable amounts of fluorine in outer facial enamel . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
38,
41
]
} | {
"id": "C0016327",
"name": "fluorine",
"pos": [
130,
138
]
} |
in teeth extracted one day after a single application of naf varnish , the retained fluorine is higher than in teeth retained in oral environment for one or five weeks after application . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
57,
60
]
} | {
"id": "C0016327",
"name": "fluorine",
"pos": [
84,
92
]
} |
these results are consistent with the following hypothesis : altered binding by the tumor of cyclic nucleotides to putative nuclear ' r-gulatory ' proteins ( e.g . protein kinase subunits , or possibly other high affinity cyclic nucleotide-binding proteins unrelated to protein kinases ) contributes to atative nuclear '... | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
124,
131
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
434,
442
]
} |
these results are consistent with the following hypothesis : altered binding by the tumor of cyclic nucleotides to putative nuclear ' r-gulatory ' proteins ( e.g . protein kinase subunits , or possibly other high affinity cyclic nucleotide-binding proteins unrelated to protein kinases ) contributes to atative nuclear '... | NA | {
"id": "C0599220",
"name": "protein",
"pos": [
147,
154
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
434,
442
]
} |
half of the patients studied with respect to refractive error became more myopic with an average change of -1.01 diopters . | NA | {
"id": "C0034951",
"name": "refractive",
"pos": [
45,
55
]
} | {
"id": "C0027092",
"name": "myopic",
"pos": [
74,
80
]
} |
the aldehydes and ammonia condense to aldimines which add hcn to form alpha-amino nitriles , all in the gas phase . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
18,
25
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
104,
107
]
} |
the effectiveness of cations for activating the electrogenic na pump was rb greater than or equal to k greater than nh4 greater than cs , and nh4 ions seemed to be unique in their stimulating action . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
21,
28
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
146,
150
]
} |
the enzyme responsible for forming m2-guanine between the dihydrouridine and anticodon loops ( m2-guanine methyltransferase ii ) has a ki of 0.3 mum , while m1-adenine methyltransferase shows intermediate sensitivity to sah ( ki = 2.4 mum ) . | NA | {
"id": "C0070781",
"name": "methyltransferase ii",
"pos": [
106,
126
]
} | {
"id": "C0025831",
"name": "methyltransferase",
"pos": [
168,
185
]
} |
the effect of long-term administration of adrenaline , metanephrine and propranolol on the triphasic intestinal reaction on adrenaline in the rat . | NA | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
55,
67
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
124,
134
]
} |
the effect 6 weeks long treatment of rats with l-adrenaline ( 1 mg/kg sc ) , d , l-metanephrine ( 20 mg/kg sc ) and d-propranolol ( 10 mg/kg po ) on isolated ileum triphasic reaction on adrenaline was studied . | NA | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
83,
95
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
186,
196
]
} |
adrenaline and metanephrine increased the sensitivity of relaxation response and decreased the contraction phase of smooth muscle to adrenaline . | NA | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
15,
27
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
133,
143
]
} |
the change in the blood oxygen affinity which occurs in the foetus and the newborn have been attributed in some species to the presence of a foetal haemoglobin ( hbf ) which differs from the adult haemoglobin ( hba ) either by an intrinsically higher oxygen affinity , independant of any intracellular cofactor , or by a... | NA | {
"id": "C0015936",
"name": "hbf",
"pos": [
162,
165
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
433,
444
]
} |
the change in the blood oxygen affinity which occurs in the foetus and the newborn have been attributed in some species to the presence of a foetal haemoglobin ( hbf ) which differs from the adult haemoglobin ( hba ) either by an intrinsically higher oxygen affinity , independant of any intracellular cofactor , or by a... | NA | {
"id": "C0019016",
"name": "hba",
"pos": [
211,
214
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
433,
444
]
} |
addition to the cultivation medium ( meat-peptone broth ) of tween-80 ( 0.25 % ) caused an increase of proteins , lipids and polysaccharides in cells and an enhancement of their telerance to lyophilization . | NA | {
"id": "C0030966",
"name": "peptone",
"pos": [
42,
49
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
103,
111
]
} |
the proteinase inhibition by fe3+ in the presence of citric acid is an indirect evidence of the existence of several carboxy groups and , possibly , of a hydroxy group in the active centre of acid proteinases from aspergillus terricola . | NA | {
"id": "C0030946",
"name": "proteinase",
"pos": [
4,
14
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
197,
208
]
} |
the seemings km of the immobilized enzyme varied insignificantly as compared with km of the soluble enzyme . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
23,
41
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
100,
106
]
} |
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