text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the stimulating effect of creatine on rna-poly-merase deals with a definite enzyme fraction and it is caused by the augmentation of the transcriptional complex enzyme activity . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
76,
82
]
} | {
"id": "C0026741",
"name": "complex enzyme",
"pos": [
152,
166
]
} |
the analysis of amino acid composition and c-terminal sequency using carboxypeptidase y has shown that the peptide structure is identical to the amino acid sequence of the respective peptide from the subfraction 3 of rabbit thymus f1 histone , in the latter glycine being substituted with alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
16,
26
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
258,
265
]
} |
the analysis of amino acid composition and c-terminal sequency using carboxypeptidase y has shown that the peptide structure is identical to the amino acid sequence of the respective peptide from the subfraction 3 of rabbit thymus f1 histone , in the latter glycine being substituted with alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
16,
26
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
289,
296
]
} |
only tartrate inhibitable ap is occurring in two cases , in another case tartrate resistant ap is found in high activity . | NA | {
"id": "C0001109",
"name": "ap",
"pos": [
26,
28
]
} | {
"id": "C0297331",
"name": "tartrate",
"pos": [
73,
81
]
} |
1 the concentrations of noradrenaline and adrenaline in various organs , arterial plasma and venous outflow from isolated hearts of adult chickens have been determined . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
24,
37
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
42,
52
]
} |
2 the relative adrenaline concentrations ( percentage of the sum of noradrenaline and adrenaline ) in the heart ( 33 % ) , spleen ( 16 % ) and brain ( 26 % ) were higher than those found in mammalian organs . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
68,
81
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
86,
96
]
} |
chemical sympathectomy by pretreatment with 6-hydroxydopamine caused a decrease of the noradrenaline and adrenaline concentrations in the heart to 20 and 23 % and in the spleen to 16 and 29 % , respectively . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
87,
100
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
105,
115
]
} |
3 stimulation of the right sympathetic nerves , infusion of tyramine or infusion of a modified tyrode solution containing 108mm k+ and 44 mm na+ caused an output of both noradrenaline and adrenaline into the perfusate of isolated hearts . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
170,
183
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
188,
198
]
} |
in the individual experiments , the noradrenaline : adrenaline ratios of the stimulation perfusates were positively correlated with the ratios found in the hearts . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
36,
49
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
52,
62
]
} |
4 the effects of noradrenaline and adrenaline on cardiac rate and tension development were studied in spontaneously beating right atria and electrically driven left atria , respectively . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
17,
30
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
35,
45
]
} |
in addition , the arterial pressure rise in response to noradrenaline or adrenaline was ; measured in chickens . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
56,
69
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
73,
83
]
} |
5 it is concluded that , in the chicken heart and spleen , both noradrenaline and adrenaline act as sympathetic neutrotransmitters . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
64,
77
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
82,
92
]
} |
three patients with oligomenorrhoea and hirsutism thought to have the polycystic ovary syndrome were found to have only one ovarian cyst . | NA | {
"id": "C0032460",
"name": "polycystic",
"pos": [
70,
80
]
} | {
"id": "C0029927",
"name": "ovarian cyst",
"pos": [
124,
136
]
} |
earlier work by others has shown that the catecholamines , epinephrine and isoproterenol , can raise blood calcium levels in parathyroidectomized but not intact rats , and can restrict the hypocalcemic effect of injected thyrocalcitonin ( tct ) . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
42,
56
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
75,
88
]
} |
in this paper the genetic basis of susceptibility to ohp is explored and compared to the control of susceptibility to glucosamine ( ga ) which also produces a crc phenocopy . | NA | {
"id": "C0314657",
"name": "genetic",
"pos": [
18,
25
]
} | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
100,
114
]
} |
epstein-barr ( e-b ) viral titers to both viral capsule antigen and early antigen were not elevated . | NA | {
"id": "C0003342",
"name": "viral",
"pos": [
21,
26
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
74,
81
]
} |
the distribution of cyclocytidine and cytosine arabinoside has been studied in normal bdf mice and in mice bearing 6-day solid l1210 lymphocytic leukemia by whole-body radioautography , bioassay , and radiochemical techniques . | NA | {
"id": "C0010557",
"name": "cyclocytidine",
"pos": [
20,
33
]
} | {
"id": "C0010711",
"name": "cytosine arabinoside",
"pos": [
38,
58
]
} |
radioactivity was widely distributed throughout the tissues between 15 minutes and 12 hours after a single intravenous dose of either cyclocytidine-2-14c or cytosine arabinoside-2-14c . | NA | {
"id": "C0010557",
"name": "cyclocytidine",
"pos": [
134,
147
]
} | {
"id": "C0010711",
"name": "cytosine arabinoside",
"pos": [
157,
177
]
} |
inhibition of antilymphoma allograft response in normal and lethally irradiated mice by cyclophosphamide ( nsc-26271 ) and isophosphamide ( nsc-109724 ) . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
88,
104
]
} | {
"id": "C0020823",
"name": "isophosphamide",
"pos": [
123,
137
]
} |
cyclophosphamide and isophosphamide ( an analog ) were tested for their effect on the antilymphoma allograft reaction in normal and lethally irradiated mice . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
0,
16
]
} | {
"id": "C0020823",
"name": "isophosphamide",
"pos": [
21,
35
]
} |
while isophosphamide was found to be less toxic than cyclophosphamide , the effect of humoral response and dna synthesis was comparable . | NA | {
"id": "C0020823",
"name": "isophosphamide",
"pos": [
6,
20
]
} | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
53,
69
]
} |
adriamycin , bcnu , bleomycin , guanazole , acronycine , isophosphamide , dtic , icrf-159 , cyclophosphamide , vincristine , and vinblastine were adminstered intraperitoneally to random groups of normal mice . | NA | {
"id": "C0020823",
"name": "isophosphamide",
"pos": [
57,
71
]
} | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
92,
108
]
} |
these experiments suggest that children with metastatic neuroblastoma may respond to cyclophosphamide , isophosphamide , and bcnu , while dtic , adriamycin , icrf-159 , guanazole , and the vinca alkaloids may also be effective . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
85,
101
]
} | {
"id": "C0020823",
"name": "isophosphamide",
"pos": [
104,
118
]
} |
a simple , preparative route in nine steps from methyl alpha-d-mannopyranoside ( 1 ) is described that affords , in 40 % overall yield , the title amino sugar 11 , the sugar constituent of the antitumor antibiotics adriamycin and daunorubicin . | NA | {
"id": "C0002531",
"name": "amino sugar",
"pos": [
147,
158
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
168,
173
]
} |
intracoronary administration of isoprenaline , adrenaline , and the noradrenaline in the langendorff-type transplanted dog heart transiently decreased coronary blood flow measured from the inflow vessel ; | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
47,
57
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
68,
81
]
} |
throughout the entire culture period , cells characterized as fibroblasts by phase contrast microscopy gave only a weak reaction with fluoresceinated antibodies to myosin showing `` '' a-fibrils '' '' but no `` '' myosin aggregates '' '' . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
39,
44
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
62,
73
]
} |
the subcellular distribution of free and esterified cholesterol in mouse testis and the changes occurring in cholesterol content of whole testes and cell fractions after inhibition of gonadotropins with methallibure ( ici 33 , 828 ) and restimulation with human chorionic gonadotropin ( hcg ) are reported in the present... | NA | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
41,
63
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
109,
120
]
} |
together with the results obtained by mass spectrometry of permethylated glycolipids [ 26 ] the following structures were elucidated : alpha-d-gakactpurampsu ; - ( 1 leads to 3 ) [ alpha-l-fucopyranosyl- ( 1 leads to 2 ) ] -d-galactopyranosyl- ( 1 leads to 4 ) -n-acetyl-d-glucosaminosyl- ( 1 leads to 3 ) -d-galactopyra... | NA | {
"id": "C0017950",
"name": "glycolipids",
"pos": [
73,
84
]
} | {
"id": "C0017978",
"name": "glycosphingolipid",
"pos": [
402,
419
]
} |
using partially specific antisera combined with a 1 step celite microcolumn chromatography , progesterone ( p ) , 20alpha-hydroxypregn-4-ene-3-one ( 20alpha-p ) , 17-hydroxyprogesterone ( 17-p ) , and 16alpha-hydroxyprogesterone ( 16alpha-p ) could be measured in the same 1 ml aliquot of plasma . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
93,
105
]
} | {
"id": "C0012311",
"name": "20alpha-hydroxypregn-4-ene-3-one",
"pos": [
114,
146
]
} |
using partially specific antisera combined with a 1 step celite microcolumn chromatography , progesterone ( p ) , 20alpha-hydroxypregn-4-ene-3-one ( 20alpha-p ) , 17-hydroxyprogesterone ( 17-p ) , and 16alpha-hydroxyprogesterone ( 16alpha-p ) could be measured in the same 1 ml aliquot of plasma . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
93,
105
]
} | {
"id": "C0020387",
"name": "hydroxyprogesterone",
"pos": [
209,
228
]
} |
the cytolytic ability of sensitized spleen cells to kill allogeneic target cells in vitro , a correlate of cell-mediated immune activity , was assessed in aging long-lived hybrid mice . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
57,
67
]
} |
the severity and consistency of inducing the disease in the marmoset by an active immunization process suggests this system may serve as an excellent animal model for autoimmune diseases falling within the syndrome of idiopathic thrombocytopenic purpura in man . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
167,
186
]
} | {
"id": "C0398650",
"name": "idiopathic thrombocytopenic purpura",
"pos": [
218,
253
]
} |
this precipitation was unaffected by the patients 's igg , but was markedly enhanced by extremely small amounts of the patient 's d less than 1-075 lipoprotein fraction or of homologous very low density lipoprotein ( vldl ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
148,
159
]
} | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
186,
214
]
} |
fixation of semi-purified human c1 paralleled these results closely : it occurred with the patient 's igm alone at 0 degrees but not at 37 degrees c , while igm in the presence of the patient 's lipoprotein , or of vldl from normal serum , fixed c1 strongly at 37 degrees as well as at 0 degrees c . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
195,
206
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
215,
219
]
} |
fab dimers and monomers prepared from the patient 's igm did not aggregate in the cold , even in the presence of lipoprotein , and did not inhibit the aggregation of intact igm in the presence of vldl , at any temperature . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
113,
124
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
196,
200
]
} |
chromatographic resolution of glucosaminidase secreted by normal fibroblasts into the culture medium shoed that component a comprised two forms , a serum-type and a tissue-type , whereas only a serum-type was found in i-cell medium . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
65,
76
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
220,
224
]
} |
the stimulation of renin secretion by non-vasocontrictor infusions of adrenaline and noradrenaline in the isolated rat kidney . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
70,
80
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
85,
98
]
} |
under these conditions adrenaline and noradrenaline significantly increased renin secretion rates , compared with control experiments in which no catecholamine was infused . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
23,
33
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} |
mean renal perfusion pressure during both adrenaline and noradrenaline infusion paralleled the control study by showing a progressive fall . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
42,
52
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
57,
70
]
} |
the hematoma was distinctly localized in 59 children , whereas it was widespread in 45 , meaning that , excepting the coronal suture , the cranial sutures do not limit the spreading of an extradural hematoma . | NA | {
"id": "C0018944",
"name": "hematoma",
"pos": [
4,
12
]
} | {
"id": "C0238154",
"name": "extradural hematoma",
"pos": [
188,
207
]
} |
a polyoxypropylene-polyoxyethylene block copolymer of about 4750 daltons ( poloxamer 108 , pluronic f-38 ) used in a new protein fractionation procedure may be infused into patients receiving therapeutic plasma fractions . | NA | {
"id": "C0032483",
"name": "polyoxyethylene",
"pos": [
19,
34
]
} | {
"id": "C0600615",
"name": "poloxamer",
"pos": [
75,
84
]
} |
digitoxin and digitoxigenin also interfered with the binding of [ 3h ] dht and had an estimated kd of 0.8-3.6 x 10 ( -8 ) m . | NA | {
"id": "C0012258",
"name": "digitoxin",
"pos": [
0,
9
]
} | {
"id": "C0012257",
"name": "digitoxigenin",
"pos": [
14,
27
]
} |
because they readily extract free cyanide as well as anionic metab cyano complexes , the high-molecular-weight quaternary amines show considerable promise for industrial pollution abatement applications . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
34,
41
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
53,
60
]
} |
protein-chemical evidence as well as the behavior of two mutant proteins ii* very strongly suggest that this protein consists of a single polypeptide chain and that in the strains studied there is no other major protein with similar characteristics . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
57,
72
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
212,
219
]
} |
the pattern of alkali-stable oligonucleotides of rna methylated in vitro was analyzed and found to correspond closely to that of ribosomal rna labelled in vivo . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
49,
52
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
129,
142
]
} |
virion rna and cellular rna have been separated by specific hybridization with a surplus of unlabelled viral complementary rna and rnase digestion . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
7,
10
]
} | {
"id": "C0035736",
"name": "viral",
"pos": [
103,
108
]
} |
the molecular weight of the enzymes were estimated by the elution volumes from a sephadex g-100 column and were found to be about 43,000 ( isoenzyme 1 ) and 69,000 ( isoenzyme 2 ) . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
28,
35
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
166,
175
]
} |
the substrate analogue , l-canavanine , homologue l-homoarginine and other basic amino acids like l-lysine and l-ornithine inhibited the enzyme activity competitively , homoarginine being the most effective in this respect . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
75,
92
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
100,
106
]
} |
large , kinetically inert , complex anions like pt ( cn ) 2-4 and au ( cn ) -2 are found to act as strong competitors towards halogen ions for the high-affinity anion binding sites of a number of proteins . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
36,
42
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
134,
138
]
} |
for some other metallo-proteins like carbonic anhydrase and a zinc - serum-albumin complex considerably greater quadrupole coupling constants were obtained . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
23,
31
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
75,
82
]
} |
kinetics of incorporation of labelled fatty acids into the sn-positions points to a non-random distribution with respect to the major saturated and unsaturated fatty acids in triacylglycerols of larvae of ceratitis capitata . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
38,
49
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
148,
171
]
} |
ferritin was either coupled directly to the polysaccharide backbone of the carrier or conjugated with pure rabbit anti-aminopeptidase in order to visualize covalently bound leucine aminopeptidase by the immunferritin technique . | NA | {
"id": "C0002570",
"name": "aminopeptidase",
"pos": [
119,
133
]
} | {
"id": "C0023402",
"name": "leucine aminopeptidase",
"pos": [
173,
195
]
} |
treatment of the resultant polysomal complex with pancreatic rnase yields ribosomes with f2 rna fragments protected against rnase . | NA | {
"id": "C0035541",
"name": "pancreatic rnase",
"pos": [
50,
66
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
124,
129
]
} |
analysis of whole-cell rna pulse-labeled with ( me-3h ) methionine , or nucleolar rna pulse-labeled with ( 3h ) uridine in the presence of tubercidin ( inhibitor of rrna processing ) , as well as electron microscopy of high-molecular-weight rna fractions confirm that the 40-s precursor rrna ( 2.8 x 10 ( 6 ) ) is the pr... | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
23,
26
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
287,
291
]
} |
in studies on the hydrolysis of trna by other endoribonucleases , several of the nucleic-acid-binding compounds ( e.g. , quinacrine and ethidium ) exhibited appreciable inhibition of both ribonuclease n1 and ribonuclease t1 . | NA | {
"id": "C0014241",
"name": "endoribonucleases",
"pos": [
46,
63
]
} | {
"id": "C0018364",
"name": "ribonuclease t1",
"pos": [
208,
223
]
} |
the monosubstituted ( on the alpha-amino group ) and the disubstituted ( on both amino groups ) acetylated components have been separated by chromatography on deae-cellulose and cm-cellulose . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
159,
173
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
181,
190
]
} |
the assay is based on the displacement of radioactively-labelled prolyl hydroxylase from its antibody by the non-labelled enzyme , and on the subsequent precipitation of the enzyme-antibody complex by a cellulose-bound second antibody . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
122,
128
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
174,
180
]
} |
penetration of arginine into the matrix space occurs only in respring mitochondria and in the presence of anions such as acetate and phosphate ; | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
106,
112
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
133,
142
]
} |
polyadenylated rna was isolated from fission yeast ( schizosaccharomyces pombe ) total rna using oligo ( dt ) -cellulose , and was studied as a model for messenger rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
15,
18
]
} | {
"id": "C0035696",
"name": "messenger",
"pos": [
154,
163
]
} |
beta ( 1-4 ) -galactosyltransferase from human milk ( the a protein of lactose synthase ) has been found to be heterogeneous when fractionated by affinity chromatography against insolubilized alpha-lactalbumin , using a linear gradient of decreasing n-acetylglucosamine concentration . | NA | {
"id": "C0016964",
"name": "galactosyltransferase",
"pos": [
14,
35
]
} | {
"id": "C0022952",
"name": "lactose",
"pos": [
71,
78
]
} |
the authors are of the opinion that non glucose carbohydrates are necessary if the facilities for frequent blood sugar controls are not available . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
40,
47
]
} | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
107,
118
]
} |
aside from cholesterol , cholesterol esters and lyso-lecithin , the de novo lipid synthesic mechanisms which operate in cells grown in the presence of beta-amino-propionitrile are largely depressed and suggest that there may be in operation specific metabolic control mechanisms for regulation of cellular lipid composit... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
11,
22
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
25,
43
]
} |
this apparent paradox is explained on the basis of a synergistic interaction between favism and g-6-pd deficiency that provides increased protection against malaria compared to that of the g-6-pd deficiency alone . | NA | {
"id": "C0015702",
"name": "favism",
"pos": [
85,
91
]
} | {
"id": "C2939465",
"name": "g-6-pd deficiency",
"pos": [
189,
206
]
} |
mean age-adjusted death rates for gastric cancer in chile for 1960 , 1962 and 1964 were associated with exposure to sodium nitrate and nitrates ( nano3 and kno3 ) used as fertilizers , by province . | NA | {
"id": "C0074748",
"name": "sodium nitrate",
"pos": [
116,
130
]
} | {
"id": "C0028125",
"name": "nitrates",
"pos": [
135,
143
]
} |
a high solubility was found in polar organic solvents ( ethanol-acetone 9:1 , and chloroform-methanol 1:1 ) , whereas gif seems to be insoluble in pure chloroform . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
56,
63
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
93,
101
]
} |
pial arteries are highly sensitive to noradrenaline , adrenaline , histamine , serotonin , rapid stretching , and potassium ions . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
54,
64
]
} |
australia antigen or hepatitis b antigen ( hbag ) is intimately associated with acute and chronic forms of serum hepatitis . | NA | {
"id": "C0019168",
"name": "australia antigen",
"pos": [
0,
17
]
} | {
"id": "C0019165",
"name": "hepatitis b antigen",
"pos": [
21,
40
]
} |
the circular dna , the dna polymerase and the dna product of the enzyme reaction appear to be internal components of the 28 nm core of the dane particle . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
4,
16
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
46,
49
]
} |
the barker hepatitis agent could be serially propagated with difficulty while the berlin agent consistently induced a striking biochemical and morphological hepatitis in the inoculated animals . | NA | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
11,
20
]
} | {
"id": "C0019188",
"name": "hepatitis",
"pos": [
157,
166
]
} |
haematomata usually underlie the open neural plate at an early stage and they form by extravasation of blood from the dorsal aortae into the blebs . | NA | {
"id": "C0018944",
"name": "haematomata",
"pos": [
0,
11
]
} | {
"id": "C0019080",
"name": "extravasation of blood",
"pos": [
86,
108
]
} |
whereas l-glucose or saline produced no significant changes in plasma insulin or glucose concentrations , d-glucose , n-acetylglucosamine , d-glucosamine , fructose , d-glyceraldehyde and dl-glyceraldehyde were potent secretagogues . | NA | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
118,
137
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
142,
153
]
} |
insulin , proinsulin and glucagon extracted from lean rat pancreases were studied in radioimmunoassay , radioreceptorassay and bioassay systems . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
10,
20
]
} |
genetically obese rats ( zucker , `` '' fatty '' '' ) were compared to their lean littermates with respect to insulin , proinsulin and glucagon extracted from their pancreases . | NA | {
"id": "C0021641",
"name": "insul",
"pos": [
110,
115
]
} | {
"id": "C0033362",
"name": ", proinsul",
"pos": [
118,
128
]
} |
in the radioimmunoassays , the radioreceptorassays and the bioassays , insulin , proinsulin and glucagon from obese rats were indistinguishable from insulin , proinsulin and glucagon from lean rats . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
71,
78
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
159,
169
]
} |
these studies demonstrate long term viability , in monolayer culture , of cells derived from this islet cell adenoma , with retention of secretory characteristics consistent with data obtained prior to removal of the adenoma from the patient . | NA | {
"id": "C0022134",
"name": "islet cell adenoma",
"pos": [
98,
116
]
} | {
"id": "C0001430",
"name": "adenoma",
"pos": [
217,
224
]
} |
insulin antibodies coupled to sepharose were used to bind human proinsulin and insulin in the serum and after centrifugation c-peptide was determined in the supernatant . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
64,
74
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
125,
134
]
} |
it is suggested that displacement found with most antisera is due to substances in serum that are not related to c-peptide or proinsulin . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
113,
122
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
126,
136
]
} |
since ribosomal rna synthesis is unnecessary for these differentiations , necessary rna synthesis would be messenger or transfer rna , or rna of unknown identity . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
6,
19
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
138,
141
]
} |
since ribosomal rna synthesis is unnecessary for these differentiations , necessary rna synthesis would be messenger or transfer rna , or rna of unknown identity . | NA | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
120,
132
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
138,
141
]
} |
[ beta-cholesterol in pregnancy cholestasis . iii . protein metabolism in women with pregnancy cholestasis and the cholesterol contents in serum beta-lipoproteins ] . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
7,
18
]
} | {
"id": "C0023824",
"name": "cholesterol",
"pos": [
115,
126
]
} |
the weight of the fetus , +/- 10 % , as a function of gestational age starting on day 28 is : weight in grams = 2.6477 x 10 ( -10 ) exp ( see article ) when t = gestational age of 28 days or more . | NA | {
"id": "C0751992",
"name": "weight",
"pos": [
4,
10
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
94,
100
]
} |
the relationship of three variables gestational age , fetal weight , and fetal crown-rump length can also be expressed mathematically : gestational age in days = 15.335 + 3.9805 ( crown-rump length in cm ) -0.0675 ( weight in grams ) equations for crown-rump length or weight were calculated , but the inaccuracy of thes... | NA | {
"id": "C0751992",
"name": "fetal",
"pos": [
54,
59
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
269,
275
]
} |
these include hiatal hernia , carcinoma of esophagus , stomach , pancreas , bile ducts and colon , intestinal obstruction ( ileus ) by neoplastic growth , gallstone ileus , external hernia and operative adhesions and especially diverticular diseases of the colon and its complications and ischemic colitis by mesenteric ... | NA | {
"id": "C0021843",
"name": "intestinal",
"pos": [
99,
109
]
} | {
"id": "C1258215",
"name": "ileus",
"pos": [
165,
170
]
} |
following an introduction on the notion of posttraumatic headache and on the etiology and pathogenesis of headache occurring after head injuries , the author discusses in detail the clinical aspects of such pain . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
57,
65
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
207,
211
]
} |
two kinds of carbohydrate chains could be characterized : oligosaccharides composed of glucosamine , mannose , galactose , fucose and sialic acid , and glucosylgalactose disaccharides . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
58,
74
]
} | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
170,
183
]
} |
procollagen has an additional n-terminal extension with a length of about 160 a , but no difference was observed between collagen and procollagen at their c-terminal ends . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
3,
11
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
134,
145
]
} |
immunological studies on nucleic acids : an investigation of the antigenic determinants of denatured deoxyribonucleic acid ( dna ) reactive with rabbit anti-dna antisera by a radioimmunoassay technique . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
25,
38
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
157,
160
]
} |
we recommend a different approach in the treatment of badly comminuted and open 'high-energy ' fractures . | NA | {
"id": "C0476171",
"name": "comminuted",
"pos": [
60,
70
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
95,
104
]
} |
the drug och3ch2udr should be given a careful , well-controlled evaluation of its effectiveness in the treatment of herpes simplex infections in animals , perhaps including humans , since our results using in vitro models show that cellular responses important for recovery from herpesvirus infections are unaffected by ... | NA | {
"id": "C0019348",
"name": "herpes simplex",
"pos": [
116,
130
]
} | {
"id": "C0019372",
"name": "herpesvirus infections",
"pos": [
279,
301
]
} |
fragment a prepared from purified diphtherial toxin and nontoxic mutant proteins that cross-react immunologically with toxin can be assayed directly by rpha , but the sensitivity of the assay for these proteins is less than for native diphtherial toxin . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
65,
80
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
202,
210
]
} |
in order of bacteriostatic effectiveness , the in vitro activity of the antibiotics studied was : cephapirin ( median mic = 0.78 mcg/ml ) , cephalothin ( median mic = 1.56 mcg/ml ) , cefazolin ( median mic : 1.56 mcg/ml ) , cephaloridine ( median mic = 3.12 mcg/ml ) , cefoxitin ( median mic = 3.12 mcg/ml ) , cephradine... | NA | {
"id": "C0007738",
"name": "cephradine",
"pos": [
310,
320
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
354,
364
]
} |
the reactions of mobile electrons ( em- ) and oxygen radical anions ( o -- ) with halogenated bases and nucleosides have been studies in gamma-irradiated alkaline glasses by e.s.r . and specific halogen-ion electrode techniques . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
61,
67
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
203,
206
]
} |
it is shown that electrons react with halogenated uracil bases ( xur where x = cl , br . i but not f ) by dissociative electron attachment to form uracil-5-yl radicals ( u- ) and halogen anions . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
0,
1
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
187,
193
]
} |
it is shown that electrons react with halogenated uracil bases ( xur where x = cl , br . i but not f ) by dissociative electron attachment to form uracil-5-yl radicals ( u- ) and halogen anions . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
99,
100
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
187,
193
]
} |
the excretion of the enzyme gamma-glutamyl-transpeptidase and its isoenzymes into the urine was investigated in patients with renal diseases and compared with the excretion of the enzymes leucine-aminopeptidase and lactate-dehydrogenase . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
66,
76
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
180,
187
]
} |
the alterations of the isoenzyme pattern during diseases with increased enzyme excretion are in accordance with the hypothesis that the enzymes are liberated from the kidney tissue into the urine , and only a minority stems from the blood . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
23,
32
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
136,
143
]
} |
proceedings : significance of serum creatine phosphokinase isoenzymes in acute myocardial infarction with atypical enzyme profile . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
59,
69
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
115,
121
]
} |
monovolent anions ( acetate , chloride and fluoride ) and sulphate had no effects on bacterial aggregation in salivary concentrations . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
11,
17
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
30,
38
]
} |
monovolent anions ( acetate , chloride and fluoride ) and sulphate had no effects on bacterial aggregation in salivary concentrations . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
11,
17
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
43,
51
]
} |
monovolent anions ( acetate , chloride and fluoride ) and sulphate had no effects on bacterial aggregation in salivary concentrations . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
11,
17
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
58,
66
]
} |
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