text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
detection of this mrna-rrna complex strongly supports the hypothesis that during the initiation step of protein biosynthesis the 3 ' end of 16s rna base pairs with the polypurine stretch common to initiator regions in e. coli and bacteriophage mrnas . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
23,
27
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
245,
248
]
} |
the proteins were purified and characterized with respect to molecular weight , amino-acid composition , peptide maps , and their functional requirement in the elongation factor dependent binding of aminoacyl transfer rna to the ribosome . | NA | {
"id": "C0002520",
"name": "amino-acid",
"pos": [
80,
90
]
} | {
"id": "C0035714",
"name": "aminoacyl transfer rna",
"pos": [
199,
221
]
} |
in order to investigate the symmetry of globin gene transcription , complementary rna ( crna ) was synthesized using rabbit globin complementary dna ( cdna ) as a template for escherichia coli dna-dependent rna polymerase ( rna nucleotidyltransferase ) . | NA | {
"id": "C0035681",
"name": "dna-dependent rna polymerase",
"pos": [
193,
221
]
} | {
"id": "C0035673",
"name": "rna",
"pos": [
224,
227
]
} |
addition of the isolated inhibitor to hemin-supplemented lysates produces an inhibition of protein chain initiation similar to that observed in heme-deficiency . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
38,
43
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
144,
148
]
} |
earlier tritium exchange experiments are consistent with the presence of these hydrogen bonds in the ferredoxin structure and show that more peptide hydrogen atoms are available for exchange in apoferredoxin than in intact ferredoxin . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
8,
15
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
149,
157
]
} |
rna polymerase ( nucleosidetriphosphate : rna nucleotidyltransferase , ec 2.7.7.6 ) was purified from rifampicin-resistant bacillus subtilis , from both uninfected cells and cells infected with bacteriophage sp01 . | NA | {
"id": "C0035681",
"name": "rna polymerase",
"pos": [
0,
14
]
} | {
"id": "C0035673",
"name": "rna nucleotidyltransferase",
"pos": [
42,
68
]
} |
procollagen , the triple-stranded precursor of chick embryo skull bone collagen , contains two pro alpha1 and one pro alpha2 chains . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
0,
11
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
71,
79
]
} |
the following results of sequential , in vitro labeling at 37 degrees and of specific cleavage of procollagen proved the structure : [ ( nh2-peptide ) -collagen- ( cooh-peptide ) ] 3 with interstrand s-s links between only the cooh-peptides . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
98,
109
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
152,
160
]
} |
( iii ) tadpole tail collagenase , which cuts native collagen into triple-stranded 3/4 pieces containing the nh2 termini and 1/4 pieces containing the cooh ends , cuts procollagen into 3/4 pieces with nh2-peptides attached and 1/4 pieces attached to the disulfide-linked cooh-peptides . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
21,
29
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
168,
179
]
} |
high resolution electron micrographs of herring sperm protamine ( clupeine ) y-i provide sufficient detail to constrain the folding of the known amino-acid sequence of the protein into a unique three-dimensional configuration . | NA | {
"id": "C0033603",
"name": "protamine",
"pos": [
54,
63
]
} | {
"id": "C0009083",
"name": "clupeine",
"pos": [
66,
74
]
} |
comparison of these data with picosecond optical changes recently observed upon pulsed laser excitation of bacterial reaction centers leads us to propose that bacteriopheophytin is indeed a transient electron acceptor and that the primary charge separation of bacterial photosynthesis occurs between the bacteriochloroph... | NA | {
"id": "C0004638",
"name": "bacteriochlorophyll",
"pos": [
304,
323
]
} | {
"id": "C0008260",
"name": "chlorophyll",
"pos": [
398,
409
]
} |
comparison of these data with picosecond optical changes recently observed upon pulsed laser excitation of bacterial reaction centers leads us to propose that bacteriopheophytin is indeed a transient electron acceptor and that the primary charge separation of bacterial photosynthesis occurs between the bacteriochloroph... | NA | {
"id": "C0008260",
"name": "chlorophyll",
"pos": [
312,
323
]
} | {
"id": "C0031512",
"name": "pheophytin",
"pos": [
435,
445
]
} |
our results are consistent with the suggestion that these polyphosphates act as a phosphate store in the cell . | NA | {
"id": "C0032575",
"name": "polyphosphates",
"pos": [
58,
72
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
82,
91
]
} |
treatment of transformed cells with dibutyry-adenosine 3':5'-cyclic monophosphate plus testosterone or theophylline restores the normal fibroblastic appearance of the cells and stimulates the assembly of numerous cytoplasmic microtubules . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
103,
106
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
136,
148
]
} |
these light chains display different molecular weights in sodium dodecyl sulfate-polyacrylamide gels from the fibroblast light chains flc1 and flc2 synthesized in non-myogenic cells and presumptive myoblasts . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
110,
120
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
176,
181
]
} |
several lines of evidence are presented to suggest that histocompatibility antigens can be physically associated on the cell surface with viral antigens and possibly other foreign antigens . | NA | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
138,
152
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
180,
188
]
} |
on the basis of these and other observations , we propose the hypothesis that the h-2 molecules serve as adaptors that combine with viral antigens on the cell surface to form hybrid antigens containing elements of self ( h-2 ) and non-self ( virus ) . | NA | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
132,
146
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
182,
190
]
} |
the doughnut hypothesis of cytolysis by complement [ mayer , m. m. ( 1972 ) proc . nat . acad . sci . usa 69 , 2954-2958 ] describes an annular structure made up of c5b-9 ( complement factors c5b , c6 , c7 , c8 , and c9 ) which becomes inserted in the lipid bilayer of the cell membrane , thus creating a hole . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
40,
50
]
} | {
"id": "C0009545",
"name": "c5b-9",
"pos": [
165,
170
]
} |
these observations suggest the involvement of a precursor larger than proinsulin in the biosynthesis of insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
70,
80
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
104,
111
]
} |
the immune responses of the inbred guinea pig strains 2 and 13 have been determined against random terpolymers of l glutamic acid and l alanine and a third amino acid . | NA | {
"id": "C0001898",
"name": "l alanine",
"pos": [
134,
143
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
156,
166
]
} |
in pentobarbital anesthetized dogs , close arterial injections of bradykinin and kallidin elicit a dose related increase in femoral blood flow . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
66,
76
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
81,
89
]
} |
treatment with the kininase inhibitor bpp9alpha augments the femoral blood flow responses to bradykinin and kallidin by five and threefold respectively . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
93,
103
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
108,
116
]
} |
[ weak polar cardenolide of convalleria majalis l. allomethylose as a sugar component of cavellaria glycosides . 13. convalleria glycoside ] . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
70,
75
]
} | {
"id": "C0017977",
"name": "glycosides",
"pos": [
100,
110
]
} |
11-methy-delta8- , 9-nor-delta8 , and 9-nor-delta9-tetrahydrocannabinol ( thc ) , newly synthesized cannabinoids which are not 11-hydroxyated in vivo , were tested for cannabinoid activity . | NA | {
"id": "C0039663",
"name": "tetrahydrocannabinol",
"pos": [
51,
71
]
} | {
"id": "C0006864",
"name": "cannabinoid",
"pos": [
168,
179
]
} |
relaxation induced by epinephrine and by norepinephrine was inhibited after combined treatment with phentolamine and propranolol . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
22,
33
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
41,
55
]
} |
phentolamine alone diminished the response to epinephrine and to norepinephrine , but the diminution for epinephrine was greater , indicating that epinephrine has a greater affinity for alpha- than for beta-receptors in the rabbit jejunum . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
65,
79
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
147,
158
]
} |
consideration of the way water solvates cations and anions is followed by a discussion of the way these solvated ions interact with the bulk medium . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
40,
47
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
113,
117
]
} |
consideration of the way water solvates cations and anions is followed by a discussion of the way these solvated ions interact with the bulk medium . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
52,
58
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
113,
117
]
} |
this particular case may be placed within the class of transitional forms of hereditary ichthyoses , and it may thus be proved that the sjogren-larsson syndrome also has its 'formes de passage ' . | NA | {
"id": "C0020757",
"name": "ichthyoses",
"pos": [
88,
98
]
} | {
"id": "C0037231",
"name": "sjogren-larsson",
"pos": [
136,
151
]
} |
the total lipid content of the lymph was 450 mg/100 ml and consisted of 16-20 % cholesterol , 30-33 % triglycerides , 41 % phospholipids , 2 % free fatty acids , and 7-8 % fatty acids esterified with cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
80,
91
]
} | {
"id": "C0008387",
"name": "esterified",
"pos": [
184,
194
]
} |
the total lipid content of the lymph was 450 mg/100 ml and consisted of 16-20 % cholesterol , 30-33 % triglycerides , 41 % phospholipids , 2 % free fatty acids , and 7-8 % fatty acids esterified with cholesterol . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
143,
159
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
172,
183
]
} |
occlusion of the lad artery produced arrhythmia in all of the animals , with 39 % developing ventricular fibrillation ( vf ) . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
37,
47
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
93,
117
]
} |
epinephrine content in the adrenal venous blood increased 5-fold immediately after occlusion and was associated with the development of arrhythmia and vf . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
136,
146
]
} | {
"id": "C0042510",
"name": "vf",
"pos": [
151,
153
]
} |
bilateral ligation of the adrenal veins 1 hour prior to occlusion of the lad artery did not alter the pattern of development of arrhythmia but prevented the occurrence of vf . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
128,
138
]
} | {
"id": "C0042510",
"name": "vf",
"pos": [
171,
173
]
} |
pretreatment of animals with either practolol or sotalol 15 min prior to lad artery occlusion also did not affect the occurrence of arrhythmia but prevented the incidence of vf . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
132,
142
]
} | {
"id": "C0042510",
"name": "vf",
"pos": [
174,
176
]
} |
the effect of catecholamines , represented by epinephrine and norepinephrine , on the activity of phospholipase a2 from bee venom was studied . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
46,
57
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
62,
76
]
} |
the matrix , composed of a mucopolysaccharidic ground substance , collagen , and reticluin fibers , contained stem cells , four types of fusiform cells ( fibrocytes , fibroblasts , myofibroblasts , and smooth muscle cells ) , and intermediary cell type . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
167,
178
]
} | {
"id": "C0007634",
"name": "cell type",
"pos": [
243,
252
]
} |
approximately one-fourth of the cats have enlargement of all cardiac chambers , typical of congestive cardiomyopathy . | NA | {
"id": "C0018800",
"name": "enlargement",
"pos": [
42,
53
]
} | {
"id": "C0007193",
"name": "congestive cardiomyopathy",
"pos": [
91,
116
]
} |
clinical findings included right and left congestive heart failure presenting as pulmonary congestion and edema , pleural effusion , hepatomegaly , and ascites . | NA | {
"id": "C0037088",
"name": "clinical findings",
"pos": [
0,
17
]
} | {
"id": "C0013604",
"name": "edema",
"pos": [
106,
111
]
} |
isoproterenol , given at the point of maximal contractile depression induced by verapamil , restored normal force of contraction and raised cardiac cyclic amp to the same level as that observed when the catecholamine was given to untreated hearts ; | NA | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
0,
13
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
203,
216
]
} |
[ protein changes in the jejunal juice and endointestinal exudation of albumin-i 131 in acute infectious enterocolitis ] . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
2,
9
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
71,
78
]
} |
among 35 hospitalized patients with paget 's disease , 21 of whom suffered cranial involvement , 18 cases of deafness related to the bone disease were discovered by means of systematic examinations . | NA | {
"id": "C0029401",
"name": "paget 's disease",
"pos": [
36,
52
]
} | {
"id": "C0005940",
"name": "bone disease",
"pos": [
133,
145
]
} |
lecithin : cholesterol acyl transfer in plasma of normal persons in relation to lipid and lipoprotein concentration . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
80,
85
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
90,
101
]
} |
we have therefore analyzed the lcat rate and the lipid and lipoprotein concentrations in the plasma of healthy normolipidemic persons 20-60 years of age , 40 men and 40 women . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
49,
54
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
59,
70
]
} |
keeping triglyceride concentration constant , there was a positive correlation between molar lcat rate and total phospholipid , unesterified cholesterol , esterified cholesterol , or low-density lipoprotein ( ldl ) cholesterol concentration . | NA | {
"id": "C0008377",
"name": "lcat",
"pos": [
93,
97
]
} | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
155,
177
]
} |
keeping triglyceride concentration constant , there was a positive correlation between molar lcat rate and total phospholipid , unesterified cholesterol , esterified cholesterol , or low-density lipoprotein ( ldl ) cholesterol concentration . | NA | {
"id": "C0008377",
"name": "lcat",
"pos": [
93,
97
]
} | {
"id": "C0023824",
"name": "low-density lipoprotein",
"pos": [
183,
206
]
} |
the proportions of isolates of escherichia coli resistant to tetracyclines were significantly lower after 10 days ' treatment with doxycycline ( 80 % ) as well as one month later ( 24 % ) , compared to the figures for tetracycline hci ( 100 % and 46 % , respectively ) . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
61,
74
]
} | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
131,
142
]
} |
an increase in the number of e. coli resistant to tetracyclines can not be avoided , but is more limited when doxycycline is used . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
50,
63
]
} | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
110,
121
]
} |
tuberculous women were found to have an excess of pregnancy complications , miscarriage , and labour difficulties . | NA | {
"id": "C0032962",
"name": "of pregnancy",
"pos": [
47,
59
]
} | {
"id": "C0000786",
"name": "miscarriage",
"pos": [
76,
87
]
} |
in order to investigate the possible relationship between a glucose-containing pump prime and changes in plasma potassium during extracorporeal circulation , determinations were made of blood glucose and plasma insulin , potassium , and magnesium in 18 subjects undergoing open-heart surgery . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
60,
67
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
186,
199
]
} |
the patient , a 20-year-old coloured man , presented with severe steatorrhoea , malabsorption , abdominal pain and progressive general deterioration . | NA | {
"id": "C0038238",
"name": "steatorrhoea",
"pos": [
65,
77
]
} | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
80,
93
]
} |
the uptake and binding of antimitotic alkaloid colchicine has been demonstrated in washed preparations of human pletelets . | NA | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
38,
46
]
} | {
"id": "C0009262",
"name": "colchicine",
"pos": [
47,
57
]
} |
this action of heavy metals appears to be due to reversible inhibition of sulfhydryl enzymes since glutathione and thioglycolate were demonstrated to completely inhibit the cytotoxic effects of the mercury and gold containing agents , respectively . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
15,
27
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
198,
205
]
} |
this action of heavy metals appears to be due to reversible inhibition of sulfhydryl enzymes since glutathione and thioglycolate were demonstrated to completely inhibit the cytotoxic effects of the mercury and gold containing agents , respectively . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
15,
27
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
210,
214
]
} |
significant differences were seen in body weight , weights of fur and interscapular adipose tissue , and weight of adrenals in male , and the difference in weight of adrenals was more outstanding in the young than in the mature . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
42,
48
]
} | {
"id": "C0005911",
"name": "difference",
"pos": [
142,
152
]
} |
predominance of intracranial hemorrhage ( cerebral hemorrhage and subarachnoid hemorrhage ) over cerebral infarction was still evident . | NA | {
"id": "C0151699",
"name": "intracranial hemorrhage",
"pos": [
16,
39
]
} | {
"id": "C2937358",
"name": "cerebral hemorrhage",
"pos": [
42,
61
]
} |
predominance of intracranial hemorrhage ( cerebral hemorrhage and subarachnoid hemorrhage ) over cerebral infarction was still evident . | NA | {
"id": "C0151699",
"name": "intracranial hemorrhage",
"pos": [
16,
39
]
} | {
"id": "C0038525",
"name": "subarachnoid",
"pos": [
66,
78
]
} |
some chelating agents were examined for their ability to remove manganese from brain and liver ( in vivo ) and their sub-cellular fractions ( in vitro ) , of rats pretreated with manganese sulphate . | NA | {
"id": "C0024706",
"name": "manganese",
"pos": [
64,
73
]
} | {
"id": "C0065649",
"name": "manganese sulphate",
"pos": [
179,
197
]
} |
the delta5-3beta hut optimal ph , specific activity and sensitivity to the inhibitory action of various steroids are different when c19 and c21 steroids are used as substrates . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
104,
112
]
} | {
"id": "C0033006",
"name": "c21 steroids",
"pos": [
140,
152
]
} |
the results suggest that exogenous progesterone administration during late pregnancy increases epinephrine stores by declining monoamine metabolism by mao and comt and increasing their synthesis by pnmt which is responsible for n-methylation of norepinephrine to epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
245,
259
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
263,
274
]
} |
the found changes in albumin are determined by the disorder of normal protein biosynthesis and possible metabolic damage of protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
21,
28
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
124,
131
]
} |
after 6-hour hydrolysis the solved part of the system contains about 30 % of alanine and 8.9 and 6 % of glycine , proline and hydroxyproline , respectively . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
114,
121
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
126,
140
]
} |
individuals with hypertension and impaired glucose tolerance , with heredity for vascular disease and diabetes seem to be especially at risk for early stroke . | NA | {
"id": "C0020538",
"name": "hypertension",
"pos": [
17,
29
]
} | {
"id": "C0042373",
"name": "vascular disease",
"pos": [
81,
97
]
} |
clinco-roentgenological findings were studied in 110 patients with ovoid tuberculous infiltrations of the lung , and these were compared with analogous observations of 409 pulmonary tuberculomas . | NA | {
"id": "C0041296",
"name": "tuberculous",
"pos": [
73,
84
]
} | {
"id": "C0041295",
"name": "tuberculomas",
"pos": [
182,
194
]
} |
the amniotic fluids of ewes with normal pregnancy were found to contain proteins which precipitated with hyper immune sera against blood serum and kidney , heart , and placenta proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
72,
80
]
} | {
"id": "C0032974",
"name": "placenta proteins",
"pos": [
168,
185
]
} |
[ ultrastructure and morphogenesis of ceroid pigment . i. phagocytosis and formation of lipid-containing lysosomes in kupffer cells after intravenous injection of unsaturated lipids ( author 's transl ) ] . | NA | {
"id": "C0007831",
"name": "ceroid",
"pos": [
38,
44
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
175,
181
]
} |
[ ultrastructure and morphogenesis of ceroid pigment . ii . late changes of lysosomes in kupffer cells of rat liver after phagocytosis of unsaturated lipids ( author 's transl ) ] . | NA | {
"id": "C0007831",
"name": "ceroid",
"pos": [
38,
44
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
150,
156
]
} |
the transformation of these lipid-containing lysosomes into ceroid pigment granules was studied electron-microscopically and cytochemically for a period of 12 weeks after the injection . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
28,
33
]
} | {
"id": "C0007831",
"name": "ceroid",
"pos": [
60,
66
]
} |
ceroid is formed in macrophages by heterophagocytosis of unsaturated lipid material which is also oxidized and polymerized . | NA | {
"id": "C0007831",
"name": "ceroid",
"pos": [
0,
6
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
69,
74
]
} |
a general fluorimetric method was developed for determination of noradrenaline , adrenaline , dopamine and serotonin in a single sample . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
65,
78
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
81,
91
]
} |
as judget by an internal standard the yield of noradrenaline and adrenaline was about 90 % and of dopamin -- about 75 % . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
47,
60
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
65,
75
]
} |
[ correction of endocrine-metabolic disorders in oncologic patients . the effect of biguanides ( phenformin and adebita ) , miskleron and diphenin ] . | NA | {
"id": "C0005382",
"name": "biguanides",
"pos": [
84,
94
]
} | {
"id": "C0031404",
"name": "phenformin",
"pos": [
97,
107
]
} |
thomizine , as well as the known antimetabolite of folic acid-methotrexate , suppresses the activity of dihydrofolate reductase , but contrary to it suppresses fap enzymic system , inhibiting aminopterin in the organism . | NA | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
62,
74
]
} | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
192,
203
]
} |
in alloxan-induced diabetes the content of riboflavin and fmn goes up in all of the subcellular fractions and that of fad in the nuclear liver fraction alone . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
43,
53
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
58,
61
]
} |
while administration of insulin to control animals reduces the riboflavin and fmn level in all of the subcellular fractions of the liver , in the diabetic animals such a decline is observed in the nuclei alone . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
63,
73
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
78,
81
]
} |
an additional introduction of riboflavin depresses and that of fmn - raises the fad content in diabetic animals as compared to controls . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
30,
40
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
63,
66
]
} |
tests conducted with rats receiving for 30 days isocaloric with control rations containing an elevated amount of animal or vegetable fats ( lard , sunflower oil ) demonstrated that the influence of the said fat-rich rations on the lipogenesis in the liver presents certain peculiarities that find their expression in a d... | NA | {
"id": "C0015677",
"name": "fats",
"pos": [
133,
137
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
446,
452
]
} |
among individual amino acids under study , taken in isomolar quantities , the most intensive gastric secretion induce glycin , alanine and proline . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
17,
28
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
127,
134
]
} |
it has been found that cheeses prepared by using the above mixture do not differ from the control ones in the content of soluble forms of nitrogen , essential amino acids , volatile fatty acids , the sum-total of higher fatty acids and differ but slightly ( except for butanone-2 ) in the proportion of various carbonyl ... | NA | {
"id": "C0015691",
"name": "volatile fatty acids",
"pos": [
173,
193
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
220,
231
]
} |
heart insufficiency , cardiomegaly and pathological changes of the ecg after exclusion of coronary heart disease , congenital or acquired vitia cordis and hypertension of the greater or lesser circulatory system result in the diagnosis cardiomyopathy with the liability of further differential-diagnostic demarcation . | NA | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
22,
34
]
} | {
"id": "C0018799",
"name": "of",
"pos": [
270,
272
]
} |
the described heart catheterization technique with the swan-ganz-flow-directed catheter allows the catheterization of the aorta or , in transposition of the great arteries , the pulmonary artery , from the left ventricle via a venous entrance form the saphenous vein if an interatrial connection exists ( patent foramen ... | NA | {
"id": "C0016522",
"name": "patent",
"pos": [
305,
311
]
} | {
"id": "C0018817",
"name": "atrial septal defect",
"pos": [
328,
348
]
} |
( the first clinical death was provoked 15 to 18 months prior to the repeated death and was caused by drowning and blood loss ) . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
21,
26
]
} | {
"id": "C0013142",
"name": "drowning",
"pos": [
102,
110
]
} |
according to the depot character of the compound , ranging between ethinylestradiol and quinestrol , it exhibits a high and prolonged proliferative effect on the atropich vaginal epithelia . | NA | {
"id": "C0015011",
"name": "ethinylestradiol",
"pos": [
67,
83
]
} | {
"id": "C0034410",
"name": "quinestrol",
"pos": [
88,
98
]
} |
monospecific antiserum to the secretory iga gave a reaction of complete immunological identity with the secretory iga and a free secretory component . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
30,
43
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
129,
148
]
} |
bacteria of the citrobacter and hafnia genus were revealed in the patients with acute intestinal diseases of obscure etiology , which often were diagnosed as gastroenteritis , enteritis , etc . | NA | {
"id": "C0017160",
"name": "gastroenteritis",
"pos": [
158,
173
]
} | {
"id": "C0014335",
"name": "enteritis",
"pos": [
176,
185
]
} |
dynamics of accumulation and preservation of antibodies detectable in the phat ( phat-at ) was studied on rabbits and guinea pigs with the use of various doses of the living inactivated virus and their combination in comparison with the virus-neutralizing antibodies , antihemagglutinins and precipitins . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
45,
55
]
} | {
"id": "C0032936",
"name": "precipitins",
"pos": [
292,
303
]
} |
by protein denaturing it is possible to obtain immunochemical inert allergen-active preparations capable of detecting the cell hypersensitivity to crude bacterial proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
3,
10
]
} | {
"id": "C0004627",
"name": "bacterial proteins",
"pos": [
153,
171
]
} |
apart from rrna , there were revealed in the microsome composition up to 10 rna components in the mol wt range of from 0.4-10 ( 5 ) to 7-10 ( 5 ) dalton and 2 componnents - between 7-10 ( 5 ) and 1.7-10 ( 6 ) dalton . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
11,
15
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
76,
79
]
} |
incorporation of 3h-uridine into the rrna was the maximal 24 hours after the administration of the antigen , whereas the rna with the mol wt between 0.4-10 ( 5 ) dalton remaining practically unchanged for a period of three days after the immunization . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
37,
41
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
121,
124
]
} |
the data depicted a moderate statistically significant increase of the first and second catalytical waves in benign tumors and a significant ( 1.5 times more ) increase in malignant and metastatical tumors in comparison to the data achieved in donors . | NA | {
"id": "C0085183",
"name": "second",
"pos": [
81,
87
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
199,
205
]
} |
the phospholipids of bat which are not only membrane bound lipids are characterized by a high metabolism . | NA | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
4,
17
]
} | {
"id": "C0025249",
"name": "membrane",
"pos": [
44,
52
]
} |
amino acid analysis revealed a high content of glycine , glutamic acid and aspartic acid , and a low content of histidine and leucine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
47,
54
]
} |
the results showed that the gland cells in the female duct elaborated mucosubstances consisting of neutral mucins , glycogen , weakly sulfated sulfomucins , strongly sulfated sulfomucins and sialomucins . | NA | {
"id": "C0026682",
"name": "mucins",
"pos": [
107,
113
]
} | {
"id": "C0074477",
"name": "sialomucins",
"pos": [
191,
202
]
} |
the study of cellular sites of mucosubstance elaboration showed that there are five different types of cells , the first type elaborated neutral mucins , the second weakly sulfated sulfomucins , the third strongly sulfated sulfomucins , the fourth sialomucins and the fifth glycogen . | NA | {
"id": "C0026682",
"name": "mucins",
"pos": [
145,
151
]
} | {
"id": "C0074477",
"name": "sialomucins",
"pos": [
248,
259
]
} |
so the reineck-salt precipitation of biogenic amines is a new method beside the known ones for the ultrahistochemical amine demonstration . | NA | {
"id": "C0005496",
"name": "biogenic amines",
"pos": [
37,
52
]
} | {
"id": "C0002508",
"name": "amine",
"pos": [
118,
123
]
} |
changes in citric acid intermediated included a fall in malate , and probably also in citrate , alpha-ketoglutarate and fumarate , with a tendency towards reduction in the pool of citric acid cycle intermediates ; | NA | {
"id": "C0055819",
"name": "citric acid",
"pos": [
11,
22
]
} | {
"id": "C0008857",
"name": "citrate",
"pos": [
86,
93
]
} |
the hormone produced a small decrease in the liver glycogen , but induced a notable fall in the glycogen of muscles and a transient increase in the brain glycogen . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
45,
59
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
154,
162
]
} |
on the other hand a small decrease of the environmental temperature from 23 degrees c to 18 degree c and 20 degrees c resulted in a significant increase in the acetylcarnitine to carnitine ratio . | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
160,
175
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
179,
188
]
} |
the total activities of beta-galactosidase and n-acetyl-beta-hexosaminidase , as well as the proportion of hexosaminidase a and b components in her serum and leukocytes were normal when the assays were carried out with artificial fluorogenic substrate . | NA | {
"id": "C0005270",
"name": "beta-hexosaminidase",
"pos": [
56,
75
]
} | {
"id": "C0162330",
"name": "hexosaminidase a",
"pos": [
107,
123
]
} |
these studies included analysis for glycosidase ( beta-galactosidase , beta-glucuronidase , n-acetyl-beta-glucosamide ) , non-specific esterases , sulfatases , sulghydryl groups as well as mucous substances within the cochlea and saccus endolymphaticus of the experimental animals . | NA | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
36,
47
]
} | {
"id": "C0017776",
"name": "beta-glucuronidase",
"pos": [
71,
89
]
} |
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