text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the alpha-glucosidase showed relatively high activity not only toward maltose but also toward alpha-glucans , such as soluble starch , beta-limit dextrin , amylopectin , shellfish glycogen , and amylose . | NA | {
"id": "C0017696",
"name": "glucans",
"pos": [
100,
107
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
180,
188
]
} |
the alpha-glucosidase showed relatively high activity not only toward maltose but also toward alpha-glucans , such as soluble starch , beta-limit dextrin , amylopectin , shellfish glycogen , and amylose . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
126,
132
]
} | {
"id": "C0002728",
"name": "amylopectin",
"pos": [
156,
167
]
} |
the alpha-glucosidase showed relatively high activity not only toward maltose but also toward alpha-glucans , such as soluble starch , beta-limit dextrin , amylopectin , shellfish glycogen , and amylose . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
126,
132
]
} | {
"id": "C0002732",
"name": "amylose",
"pos": [
195,
202
]
} |
for disaccharides , the rate of hydrolysis decreased in the following order : maltose divided by nigerose greater than kojibiose greater than isomaltose . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
4,
17
]
} | {
"id": "C0024658",
"name": "maltose",
"pos": [
145,
152
]
} |
for disaccharides , the rate of hydrolysis decreased in the following order : maltose divided by nigerose greater than kojibiose greater than isomaltose . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
4,
17
]
} | {
"id": "C0022200",
"name": "isomaltose",
"pos": [
142,
152
]
} |
using sodium dodecyl sulphate/polyacrylamide gels to analyse detergent-insoluble residues , and indirect immunofluorescence , we have found that the major protein of intermediate filaments in cultures and freshly explanted fragments of chick embryonic retinal pigment epithelium ( rpe ) is vimentin . | NA | {
"id": "C0021769",
"name": "protein",
"pos": [
155,
162
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
290,
298
]
} |
the standard amino acid mixture of basic amino acids and some dipeptides usually present in physiological fluids was analysed for the development of the method . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
13,
23
]
} | {
"id": "C0301714",
"name": "amino",
"pos": [
41,
46
]
} |
as 3-methylhistidine is completely resolved from the other basic amino acids and some dipeptides ( anserine and carnosine ) , this method is suitable for the analysis of urine and muscle extracts as well as skeletal muscle protein hydrolysates where this amino acid is present in much lower concentrations than other ami... | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
59,
76
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
317,
328
]
} |
as 3-methylhistidine is completely resolved from the other basic amino acids and some dipeptides ( anserine and carnosine ) , this method is suitable for the analysis of urine and muscle extracts as well as skeletal muscle protein hydrolysates where this amino acid is present in much lower concentrations than other ami... | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
86,
96
]
} | {
"id": "C0003134",
"name": "anserine",
"pos": [
99,
107
]
} |
as 3-methylhistidine is completely resolved from the other basic amino acids and some dipeptides ( anserine and carnosine ) , this method is suitable for the analysis of urine and muscle extracts as well as skeletal muscle protein hydrolysates where this amino acid is present in much lower concentrations than other ami... | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
86,
96
]
} | {
"id": "C0007267",
"name": "carnosine",
"pos": [
112,
121
]
} |
a procedure based on automated amino acid analysis has been developed to simultaneously quantify 1-methylhistidine ( 1-mh ) , 3-methylhistidine ( 3-mh ) , tyrosine , phenylalanine , tryptophan , lysine , histidine and arginine levels in human and rat urines . | NA | {
"id": "C0301714",
"name": "based",
"pos": [
12,
17
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
195,
201
]
} |
a procedure based on automated amino acid analysis has been developed to simultaneously quantify 1-methylhistidine ( 1-mh ) , 3-methylhistidine ( 3-mh ) , tyrosine , phenylalanine , tryptophan , lysine , histidine and arginine levels in human and rat urines . | NA | {
"id": "C0301714",
"name": "based",
"pos": [
12,
17
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
218,
226
]
} |
a preparation of purified potato leafroll virus contained a single dominant protein corresponding to the viral coat protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
76,
83
]
} | {
"id": "C0042736",
"name": "viral",
"pos": [
105,
110
]
} |
the hormone also seems to affect the already differentiated cells -- chondroblasts and hypertrophic chondrocytes -- both structurally as well as metabolically . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
60,
65
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
100,
112
]
} |
antibodies against both toxins were purified by affinity chromatography from sheep antisera raised against purified eta and etb . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
83,
91
]
} |
in the sandwich elisa , a monoclonal antibody against the group-specific antigen was used as capture antibody , whereas peroxidase-conjugated monoclonal antibodies directed against group- and type-specific antigens were used as the second antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
142,
163
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
239,
249
]
} |
three different antisera to the molluscan neuropeptide phe-met-arg-phe-amide ( fmrfamide ) and two different antisera to the fragment rfamide were used to stain sections or whole mounts of the hydrozoan medusa polyorchis penicillatus . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
42,
54
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
79,
88
]
} |
as a marker for immunoreactive enkephalin , we used an antiserum directed against one of the proenkephalin products , methionine enkephalin-arg-gly-leu ( m-enk ) . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
31,
41
]
} | {
"id": "C0014295",
"name": "methionine enkephalin",
"pos": [
118,
139
]
} |
the digesting action of fibroblasts was well developed and many melanosomes were taken into the cells making the cells resemble melanophages . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
24,
35
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
113,
118
]
} |
the fibroblasts extended long , thin and branched cytoplasmic processes to surround the amyloid mass , and the cells selectively extended these into the narrow spaces between collagen and amyloid . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
4,
15
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
111,
116
]
} |
kidney filtration ratios of element to creatinine increased for magnesium when diets were supplemented with magnesium and increased for phosphorus and sodium when diets were supplemented with sodium bicarbonate . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
28,
35
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
136,
146
]
} |
however , mice fed 10 % showed normal growth and reproduction by small treatment differences in body weight changes , litter size at birth , and average pup weight . | NA | {
"id": "C0005911",
"name": "body",
"pos": [
96,
100
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
157,
163
]
} |
spectrofluorimetric determination of desoxycholic acid in the presence of cholic and chenodesoxycholic acids by use of ce ( iv ) and concentrated sulphuric acid . | NA | {
"id": "C0011479",
"name": "desoxycholic acid",
"pos": [
37,
54
]
} | {
"id": "C0008024",
"name": "chenodesoxycholic acids",
"pos": [
85,
108
]
} |
a method for the quantitative estimation of desoxycholic acid ( 200-700 micrograms/ml ) in the presence of cholic and chenodesoxycholic acids is described . | NA | {
"id": "C0011479",
"name": "desoxycholic acid",
"pos": [
44,
61
]
} | {
"id": "C0008024",
"name": "chenodesoxycholic acids",
"pos": [
118,
141
]
} |
by e.d.a.x . the calcific composition of the rounded structures could be determined : calcium and phosphorus were the main elements detectable in asteroid bodies of all sizes for all three patients . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
98,
108
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
123,
131
]
} |
hepatic s9 preparations from aroclor 1254 induced rats and 3-methylcholanthrene induced woodchucks were used to investigate , in vitro , the mutagenic potential of five amino acid conjugates of 2,4-dichlorophenoxyacetic acid ( alanine , aspartic acid , leucine , methionine and tryptophan ) . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
169,
179
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
227,
234
]
} |
chemotaxonomic studies within the family davaineidae have shown the presence of cystine and hydroxyproline only in d. hewetensis , although phenylalanine and proline occur in all species examined previously . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
92,
106
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
158,
165
]
} |
monoclonal antibodies that recognized the polymeric form of protein i frequently produced antibody-mediated , complement-dependent , bactericidal activity for gonococci bearing the same protein i serotype . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
90,
98
]
} |
competitive inhibition was observed between sta in solution and a glutaraldehyde-coupled sta-human serum albumin ( hsa ) conjugate bound to microtiter wells when antiserum raised against a glutaraldehyde-coupled sta-bovine serum albumin ( bsa ) conjugate was used as detecting antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
162,
171
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
277,
285
]
} |
it tests the ability of the sera to neutralize alpha-2 interferon and prevent the interferon from being detected by an immunoradiometric assay . | NA | {
"id": "C0021734",
"name": "alpha-2 interferon",
"pos": [
47,
65
]
} | {
"id": "C0021747",
"name": "interferon",
"pos": [
82,
92
]
} |
an analysis of these 69 oligopeptides showed that peptides of less than 10 amino acids were unlikely to produce useful antisera and that the more hydrophilic peptides were marginally more useful than those less hydrophilic . | NA | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
24,
37
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
158,
166
]
} |
the results allowed us to divide our mabs into 4 groups , recognizing 4 different epitopes , and to select 4 mabs each distinguishing a different epitope in order to pursue further studies on the antigenic structure of hcs . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
82,
89
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
196,
205
]
} |
heterogeneity in the distribution of g2m ( n ) , g3m ( b ) , a2m ( 2 ) and km ( 3 ) was found when 60 polar-lepromatous ( ll ) patients and 27 borderline-tuberculoid ( bt ) patients were separated out of the 91 leprosy patients . | NA | {
"id": "C1562908",
"name": "borderline-tuberculoid",
"pos": [
143,
165
]
} | {
"id": "C0023343",
"name": "leprosy",
"pos": [
211,
218
]
} |
[ asd plaque formation of the mitral valve in secundum atrial septal defect and the timing for operation ] . | NA | {
"id": "C0018817",
"name": "asd",
"pos": [
2,
5
]
} | {
"id": "C0016522",
"name": "secundum atrial septal defect",
"pos": [
46,
75
]
} |
the placenta contains such thrombotic factors as tissue thromboplastin , placental factor xiii , and placental urokinase inhibitor . | NA | {
"id": "C0005789",
"name": "thrombotic factors",
"pos": [
27,
45
]
} | {
"id": "C0040048",
"name": "tissue thromboplastin",
"pos": [
49,
70
]
} |
the placenta contains such thrombotic factors as tissue thromboplastin , placental factor xiii , and placental urokinase inhibitor . | NA | {
"id": "C0005789",
"name": "thrombotic factors",
"pos": [
27,
45
]
} | {
"id": "C0015528",
"name": "factor xiii",
"pos": [
83,
94
]
} |
hmg-coa reductase activity , assayed in microsomes prepared in the presence of 50 mm naf , was only 17 +/- 3 % of the activity observed in microsomes prepared from the same liver in the absence of fluoride . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
85,
88
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
197,
205
]
} |
preincubation of microsomes prepared in naf with alkaline phosphatase resulted in a tenfold increase of enzyme activity , while the activity of microsomes prepared without fluoride was increased also ( by about 45 % ) with this treatment . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
40,
43
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
172,
180
]
} |
the catabolism of apoe-3 in the individual lipoprotein subfractions was also examined and apoe was shown to be catabolized most rapidly from the vldl and slowest from the hdl . | NA | {
"id": "C0052199",
"name": "apoe-3",
"pos": [
18,
24
]
} | {
"id": "C0003595",
"name": "apoe",
"pos": [
90,
94
]
} |
from estimations of hydrodynamic radii , svedberg coefficients , and partial specific volumes , relative masses of glycosphingolipid micelles were calculated to be in the range of 300 to 1000 for the neutral glycosphingolipids and 100 to 350 for the gangliosides . | NA | {
"id": "C0017978",
"name": "glycosphingolipid",
"pos": [
115,
132
]
} | {
"id": "C0600570",
"name": "neutral glycosphingolipids",
"pos": [
200,
226
]
} |
somatostatin ( srif ) is known to inhibit the release of all pancreatic hormones but has a greater inhibitory action on glucagon secretion than it does on any of the other peptides . | NA | {
"id": "C0037659",
"name": "srif",
"pos": [
15,
19
]
} | {
"id": "C0030292",
"name": "pancreatic hormones",
"pos": [
61,
80
]
} |
analysis of the intracellular amino acid pool showed that both germ-tubes and hyphal cells were relatively depleted of several amino acids as compared to the yeast-form cells , whereas in the hyphae there was a higher concentration of glutamic acid/glutamine , the latter being the predominant component . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
235,
248
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
249,
258
]
} |
reverse phase high performance liquid chromatography was used to establish the immunoreactive species of five neuropeptides ( thyrotropin-releasing hormone , luteinising hormone-releasing hormone , neurotensin , substance-p and somatostatin ) in three areas of post mortem human brain -- the hypothalamus , amygdala and ... | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
110,
123
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
198,
209
]
} |
it was established that somatostatin-14 was present as the major immunoreactive form and that somatostatin-28 did not occur in any of the three brain areas , although other somatostatin-immunoreactive peaks of unknown structure were detected . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
94,
109
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
173,
185
]
} |
induced carcinomas , 43 lesions from 25 cases , were examined histochemically with galactose-binding lectins ( pna and rca-1 ) , n-acetyl-galactosamine-binding lectins ( dba and sba ) , a fucose-binding lectin ( uea-1 ) , and a n-acetyl-glucosamine-binding lectin ( wga ) . | NA | {
"id": "C0607430",
"name": "galactose-binding lectins",
"pos": [
83,
108
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
257,
263
]
} |
frank infarction , the microanatomy of which differs from that seen in superficial lymph nodes , is one of the nodal lesions evoked by ischaemia . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
6,
16
]
} | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
135,
144
]
} |
forty-four infants had malabsorption syndromes , 36 had short bowel syndrome , 38 had intractable diarrhea , and 86 required nutritional support for a variety of other conditions . | NA | {
"id": "C0024523",
"name": "malabsorption syndromes",
"pos": [
23,
46
]
} | {
"id": "C0036992",
"name": "short bowel syndrome",
"pos": [
56,
76
]
} |
in experimental animals , we found a consistent relationship between paco2 and end-tidal co2 ( et.co2 ) in the normal steady state , and in acid-base disturbances ( respiratory acidosis and alkalosis , and hypoperfusion acidosis ) . | NA | {
"id": "C0001127",
"name": "respiratory acidosis",
"pos": [
165,
185
]
} | {
"id": "C0001122",
"name": "acidosis",
"pos": [
220,
228
]
} |
rats were intraperitoneally immunized with ovalbumin ( egg albumin ) with incomplete freund 's adjuvant , and the effect of intravenous challenge with ovalbumin on the intestinal blood flow was measured by means of hydrogen clearance method . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
45,
52
]
} | {
"id": "C0029923",
"name": "ovalbumin",
"pos": [
151,
160
]
} |
in contrast with the plasma functional cp level as an acute-phase reactant , the exudate functional cp level was very low during the acute phase , increased in the chronic phase and reached a constant value which was only half value of the plasma functional cp level . | NA | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
54,
74
]
} | {
"id": "C0007841",
"name": "cp",
"pos": [
258,
260
]
} |
similarly to the case of cephalexin and cephradine , the absorption of amoxicillin was significantly inhibited by cyclacillin , cephradine , and cephalexin , but the absorption of ampicillin was not reduced by all tested antibiotics . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
71,
82
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
180,
190
]
} |
similarly to the case of cephalexin and cephradine , the absorption of amoxicillin was significantly inhibited by cyclacillin , cephradine , and cephalexin , but the absorption of ampicillin was not reduced by all tested antibiotics . | NA | {
"id": "C0007738",
"name": "cephradine",
"pos": [
40,
50
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
145,
155
]
} |
in the experiments using dipeptides ( 6.0 mm ) , the absorption of cyclacillin was reduced significantly by glycylglycine , not by l-carnosine . | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
25,
35
]
} | {
"id": "C0017984",
"name": "glycylglycine",
"pos": [
108,
121
]
} |
in the experiments using dipeptides ( 6.0 mm ) , the absorption of cyclacillin was reduced significantly by glycylglycine , not by l-carnosine . | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
25,
35
]
} | {
"id": "C0007267",
"name": "carnosine",
"pos": [
133,
142
]
} |
absorption , distribution , metabolism and excretion of ethyl o- [ n- ( p-carboxyphenyl ) -carbamoyl ] mycophenolate ( cam ) , a new antitumor agent , was studied in mice using 14c-labeled cam and species difference of metabolism was studied in mice , rats , guinea pigs , rabbits and dogs . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
43,
52
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
219,
229
]
} |
the effects of exposure to ozone ( o3 ) on concentrations of serum lipids and lipoproteins were investigated . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
67,
73
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
78,
90
]
} |
because elevated concentrations of lipids and lipoproteins in humans increase the risk of coronary heart disease ( chd ) , the lipoprotein results suggest that an epidemiological study of the incidence of chd with metropolitan o3 levels may be warranted . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
35,
41
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
127,
138
]
} |
after acute administration of chlordimeform ( 100 mg/kg , ip one hr prior to sacrifice ) differential effects were observed in various parameters of the hepatic microsomal mixed function oxidase system with significant decreases in ethylmorphine metabolism , cytochrome p-450 content , nadph cytochrome c reductase , and... | NA | {
"id": "C0003927",
"name": "microsomal mixed function oxidase",
"pos": [
161,
194
]
} | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
259,
275
]
} |
in a randomized , two-period crossover study in 12 normal volunteers , serum and urine concentrations of the angiotensin-converting enzyme inhibitor enalapril and its active metabolite enalaprilat were determined following administration of a single 40-mg tablet of enalapril maleate administered both in the fasting sta... | NA | {
"id": "C0014025",
"name": "enalapril",
"pos": [
149,
158
]
} | {
"id": "C0014027",
"name": "enalaprilat",
"pos": [
185,
196
]
} |
in a randomized , two-period crossover study in 12 normal volunteers , serum and urine concentrations of the angiotensin-converting enzyme inhibitor enalapril and its active metabolite enalaprilat were determined following administration of a single 40-mg tablet of enalapril maleate administered both in the fasting sta... | NA | {
"id": "C0014025",
"name": "enalapril",
"pos": [
149,
158
]
} | {
"id": "C0700452",
"name": "enalapril maleate",
"pos": [
266,
283
]
} |
the effects of the molluscan neuropeptide phe-met-arg-phe-nh2 ( fmrf amide ) and related peptides ( price & greenberg , 1977 ) were tested on helix aspersa neurones . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
29,
41
]
} | {
"id": "C0060608",
"name": "fmrf amide",
"pos": [
64,
74
]
} |
it is suggested that sinus arrhythmia in man is mediated through vagal efferents alone but that atenolol increases the arrhythmia through a central vagotonic effect . | NA | {
"id": "C0003813",
"name": "sinus arrhythmia",
"pos": [
21,
37
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
119,
129
]
} |
in the artificially perfused labyrinth , the administration of catecholamines ( adrenaline , noradrenaline and dopamine ) decreased the outflow of the internal carotid artery in many cases . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
80,
90
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
93,
106
]
} |
the study population consisted of 6 choriocarcinoma patients , 49 hydatidiform mole patients , 37 patients being monitored after spontaneous abortion or blighted ovum and 80 patients in whom the possibility of trophoblastic disease was being ruled out . | NA | {
"id": "C0020217",
"name": "hydatidiform mole",
"pos": [
66,
83
]
} | {
"id": "C2931618",
"name": "trophoblastic disease",
"pos": [
210,
231
]
} |
the exposure of animal neutrophils to crystals implicated in joint inflammation induces superoxide and peroxide generation in a concentration and temperature dependent fashion . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
88,
98
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
103,
111
]
} |
the cl response correlated with serological measures of sle activity such as antibodies to double stranded dna ( p less than .0001 ) and clq binding immune complexes ( p less than .001 ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
77,
87
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
149,
165
]
} |
our study confirms the presence of diffuse skeletal hyperostosis ( dish ) in middle eastern as well as western populations . | NA | {
"id": "C0020492",
"name": "hyperostosis",
"pos": [
52,
64
]
} | {
"id": "C0020498",
"name": "dish",
"pos": [
67,
71
]
} |
the occurrence of the triad of leukopenia , splenomegaly and rheumatoid arthritis ( ra ) ( felty 's syndrome ) during childhood has not been reported previously . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
61,
81
]
} | {
"id": "C0015773",
"name": "felty 's syndrome",
"pos": [
91,
108
]
} |
reproductive parameters measured included conception , litter size , pup birth weight , number stillborn , survival to weaning , and weaning weight . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
73,
85
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
141,
147
]
} |
previously , inhibition of growth of e. coli by paraquat and hyperbaric oxygen were shown to be prevented by inclusion in the medium of a nearly identical profile of specific amino acids , including branched-chain amino acids , which were required because of poisoning of their biosynthesis at the dihydroxyacid dehydrat... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
175,
186
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
199,
225
]
} |
residue levels of the chlorinated hydrocarbons hexachlorobenzene ( hcb ) , polychlorinated biphenyls ( pcbs ) , alpha- , beta- , and gamma-hexachlorocyclohexane ( hch ) , oxychlordane , trans-nonachlor , aldrin , and dieldrin in adult puffins ( fratercula arctica ) from two colonies in norway ( rost 67 degrees 30 ' n a... | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
22,
46
]
} | {
"id": "C0005038",
"name": "gamma-hexachlorocyclohexane",
"pos": [
133,
160
]
} |
residue levels of the chlorinated hydrocarbons hexachlorobenzene ( hcb ) , polychlorinated biphenyls ( pcbs ) , alpha- , beta- , and gamma-hexachlorocyclohexane ( hch ) , oxychlordane , trans-nonachlor , aldrin , and dieldrin in adult puffins ( fratercula arctica ) from two colonies in norway ( rost 67 degrees 30 ' n a... | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
22,
46
]
} | {
"id": "C0002011",
"name": "aldrin",
"pos": [
204,
210
]
} |
residue levels of the chlorinated hydrocarbons hexachlorobenzene ( hcb ) , polychlorinated biphenyls ( pcbs ) , alpha- , beta- , and gamma-hexachlorocyclohexane ( hch ) , oxychlordane , trans-nonachlor , aldrin , and dieldrin in adult puffins ( fratercula arctica ) from two colonies in norway ( rost 67 degrees 30 ' n a... | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
22,
46
]
} | {
"id": "C0012141",
"name": "dieldrin",
"pos": [
217,
225
]
} |
the group receiving the 45 % bcaa enriched ( low leucine ) amino acid solution exhibited a significant decrease in cumulative ( 7 day ) nitrogen balance ( 7.6 +/- 2.6 g ) compared to the groups receiving either the standard 25 % bcaa ( 19.9 +/- 2.1 g ) or the 45 % bcaa enriched ( high leucine ) ( 21.6 +/- 7.0 g ) amino... | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
29,
33
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
286,
293
]
} |
these results demonstrate that the ratio of individual bcaa and the amount of leucine were more critical to nitrogen-sparing efficacy than the percentage total bcaa infused . | NA | {
"id": "C0023401",
"name": "leucine",
"pos": [
78,
85
]
} | {
"id": "C0002521",
"name": "bcaa",
"pos": [
160,
164
]
} |
[ the simultaneous determination of plasma concentrations of norepinephrine , epinephrine and dopamine by gas chromatography-mass spectrometry ] . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
61,
75
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
78,
89
]
} |
workers in high-excretion group complained of considerable subjective symptoms and their urinary protein showed a remarkable increase , compared to middle- and low-excretion groups , and the electrophoretic pattern of urinary proteins showed preponderance of globulins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
97,
104
]
} | {
"id": "C0017649",
"name": "globulins",
"pos": [
259,
268
]
} |
( - ) -norepinephrine ( 10 nm to 1 microm ) concentration-dependently inhibited evoked 3h efflux and did not increase the parameter in the presence of 10 microm phentolamine , 10 microm cocaine and 10 microm normetanephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
7,
21
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
208,
223
]
} |
to elucidate the mechanisms of fever response by bacterial pyrogen ( lipopolysaccharide , lps ) , we investigated both pyrogenicity and limulus amoebocyte lysate ( lal ) gelation activity of cerebrospinal fluid ( csf ) withdrawn from febrile rabbits induced by i.v . injection of lps . | NA | {
"id": "C0014264",
"name": "bacterial pyrogen",
"pos": [
49,
66
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
280,
283
]
} |
[ lipids and apoproteins a1 and b in patients with ischemic heart disease with stenosing atherosclerosis of the coronary arteries and the abdominal aorta ] . | NA | {
"id": "C1956346",
"name": "disease",
"pos": [
66,
73
]
} | {
"id": "C0003850",
"name": "atherosclerosis",
"pos": [
89,
104
]
} |
the content of the protein-lipid components of lipoproteins of individual classes was studied in 87 coronary heart disease patients surviving myocardial infarction under 40 years of age . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
27,
32
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
47,
59
]
} |
the administration of probucol in combination with the diet therapy decreased cholesterol by 33.6 % , triglycerides by 32.8 % and high density lipoprotein cholesterol ( hdlc ) by 19.7 % as compared with the baseline values . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
78,
89
]
} | {
"id": "C0023822",
"name": "high density lipoprotein",
"pos": [
130,
154
]
} |
late cs more commonly took the true form and was associated with a mi relapse . | NA | {
"id": "C0036980",
"name": "cs",
"pos": [
5,
7
]
} | {
"id": "C0027051",
"name": "mi",
"pos": [
67,
69
]
} |
we investigated effects of fibrin , fibrinogen , and fibrinogen degradation products ( fdps ) on human glomerular mesangial cells in culture , using the methods of cell count , 3 [ h ] thymidine uptake and 51cr release . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
27,
33
]
} | {
"id": "C0163275",
"name": "fibrinogen degradation",
"pos": [
53,
75
]
} |
as aromatic and branched-chain amino acids compete for penetration of the blood brain barrier , the decrease of the amino acid ratio may induce a raised flux of phenylalanine and tyrosine into the cns which results in an increased activation of dopaminergic neurons -- known to cause anorexia . | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
16,
42
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
116,
126
]
} |
the effect of cimetidine treatment , 1 g daily over 6 days , on the disposition of theophylline was studied in nine patients with liver cirrhosis and in nine patients without liver disease . | NA | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
130,
145
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
175,
188
]
} |
in general , only ( delta 8- or delta 9-thc type ) cannabinoids of the dibenzopyran type structure were found to appreciably cross-react with the antiserum . | NA | {
"id": "C0039663",
"name": "thc",
"pos": [
40,
43
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
51,
63
]
} |
complete lipid and lipoprotein profiles were obtained on serum specimens from 39 guanabenz-treated , overnight-fasted patients . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
9,
14
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
19,
30
]
} |
these homogeneous ig , paraproteins , reflect three different major categories of disorders within the immune system : b-cell malignancies ; | NA | {
"id": "C0021027",
"name": "ig",
"pos": [
18,
20
]
} | {
"id": "C0030490",
"name": "paraproteins",
"pos": [
23,
35
]
} |
and cultured fibroblasts from longer lived species have greater dna repair capacity than do cells from species with shorter lifespans . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
92,
97
]
} |
the lipid peroxidation and activities of main enzymes involved in the peroxide metabolism were measured at resting conditions and after completion of a 2-month treatment with h2o2 . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
70,
78
]
} | {
"id": "C0020281",
"name": "h2o2",
"pos": [
175,
179
]
} |
taking into account the pathologic and dermatologic nomenclature we classified moles ( naevi ) as a ) melanocytic naevi , b ) vascular naevi , c ) epithelial naevi . | NA | {
"id": "C0027960",
"name": "naevi",
"pos": [
87,
92
]
} | {
"id": "C0027962",
"name": "melanocytic naevi",
"pos": [
102,
119
]
} |
the distribution of total cholesterol among lipoprotein subclasses was increased in both the intermediate density lipoprotein ( idl ) ( 1.006-1.019 g/ml ) and low density lipoprotein ( ldl ) ( 1.019-1.063 g/ml ) fractions and decreased in the high density lipoprotein ( hdl ) ( 1.063-1.21 g/ml ) fraction when casein is ... | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
44,
55
]
} | {
"id": "C0065063",
"name": "intermediate",
"pos": [
93,
105
]
} |
effect of protein depletion on the vldl triacylglycerol secretion and apoprotein synthesis by the perfused liver from pregnant rats . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
10,
17
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
70,
80
]
} |
our results suggest that , in the presence of datp , the reca441 and reca430 proteins form mixed multimers on single-stranded dna , in which the reca441 protein molecules enhance the dna binding affinity of reca430 protein molecules , but reca430 protein molecules support no cleavage of the lambda repressor . | NA | {
"id": "C0012940",
"name": "dna binding",
"pos": [
183,
194
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
247,
254
]
} |
all of the products appeared to have a composition and architecture typical of enterobacterial lps , but points of interest include the absence of phosphate residues from the core oligosaccharide , the presence of both l-glycero-d-mannoheptose and d-glycero-d-mannoheptose ( ratio usually about 4:1 ) , and the presence ... | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
95,
98
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
323,
330
]
} |
hepatic drug-metabolizing enzyme system and endotoxin tolerance : structural requirement of lps in induction of an early tolerance . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
44,
53
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
92,
95
]
} |
the results of reciprocal cross tolerance tests using lipopolysaccharide and free lipid a preparations derived from salmonella minnesota , salmonella typhimurium , e. coli , pseudomonas aeruginosa , and chromobacterium violaceum suggested that lipid a moiety plays an important role in the induction of early endotoxin t... | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
54,
72
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
244,
251
]
} |
the results of reciprocal cross tolerance tests using lipopolysaccharide and free lipid a preparations derived from salmonella minnesota , salmonella typhimurium , e. coli , pseudomonas aeruginosa , and chromobacterium violaceum suggested that lipid a moiety plays an important role in the induction of early endotoxin t... | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
54,
72
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
332,
341
]
} |
davidsohn 's differential absorption test revealed that the heterophile ab were distinct from forssman antibody , paul-bunnell antibody and heterophile agglutinins known to appear in serum sickness . | NA | {
"id": "C0003248",
"name": "heterophile ab",
"pos": [
60,
74
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
127,
135
]
} |
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