text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the results showed that during the relatively short exercise plasma noradrenaline , adrenaline and cortisol responses depend more on work intensity than on the total work output . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
68,
81
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
84,
94
]
} |
appropriate treatment in such life-threatening trauma situations will consist of a rapid primary assessment , airway and cervical spine control , appropriate respiratory and cardiovascular assistance , gross whole body fracture immobilization using a backboard , and immediate transport . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
47,
53
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
219,
227
]
} |
the gag was composed of a mixture of heparan sulfate and chondroitin sulfate or dermatan sulfate in one carcinoma tissue and mainly composed of chondroitin sulfate or dermatan sulfate in the other . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
4,
7
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
37,
52
]
} |
we have reported that iv administration of conjugated estrogens results in no significant change in the plasma lh-rh level during the negative feedback phase of lh , suggesting that estrogen does not suppress lh by decreasing hypothalamic lh-rh . | NA | {
"id": "C0014938",
"name": "conjugated estrogens",
"pos": [
43,
63
]
} | {
"id": "C0014939",
"name": "estrogen",
"pos": [
182,
190
]
} |
plasma aldosterone concentration ( pac ) , only measured at rest , was not significantly changed after the training period , while plasma norepinephrine ( pne ) and epinephrine ( pe ) concentrations were significantly decreased , but only at high levels of exercise . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
138,
152
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
165,
176
]
} |
the intracellular localization of catalytically active odc was determined by light and electron microscope autoradiography following pulselabeling of cells with alpha-difluoromethyl ( 5-3h ) ornithine ( 3h-dfmo ) at the time of peak odc activity . alpha-difluoromethylornithine ( dfmo ) is an enzyme-activated irreversib... | NA | {
"id": "C0029277",
"name": "ornithine",
"pos": [
191,
200
]
} | {
"id": "C0002260",
"name": "alpha-difluoromethylornithine",
"pos": [
248,
277
]
} |
the antibiotics tested were : benzyl-penicillin , ampicillin , cefotaxime , vancomycin , erythromycin , rifampicin , pristinamycin , gentamicin , netilmicin , tobramycin , amikacin , dibekacin and streptomycin . | NA | {
"id": "C0030827",
"name": "benzyl-penicillin",
"pos": [
30,
47
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
50,
60
]
} |
if the mic exceeds 0.1 mg l-1 , an aminoglycoside ( netilmicin or gentamicin ) should be added and the duration of treatment increased from 4 to 6 weeks . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
35,
49
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
66,
76
]
} |
this result could be explained by a saturable mechanism in the metabolism of ketoprofen to its glucuronide . however , since the renal excretion of free ketoprofen is not a major route of ketoprofen elimination , relatively large alterations in this parameter will not markedly alter elimination half-life or area under ... | NA | {
"id": "C1373187",
"name": "renal excretion",
"pos": [
129,
144
]
} | {
"id": "C1373186",
"name": "route of",
"pos": [
179,
187
]
} |
plasma protein binding may decrease in renal disease due to uremia , hypoalbuminemia , or due to drug interactions . | NA | {
"id": "C0022658",
"name": "renal disease",
"pos": [
39,
52
]
} | {
"id": "C0041948",
"name": "uremia",
"pos": [
60,
66
]
} |
as a solid , nonhygroscopic , neutral prodrug of valproic acid , valpromide may be a good alternative to valproic acid and sodium valproate . | NA | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
49,
62
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
123,
139
]
} |
in a [ 3h ] digoxin radioimmunoassay , however , digoxigenin and digoxin were equipotent but chlormadinone acetate was inactive . | NA | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
49,
60
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
65,
72
]
} |
ach ( 5 x 10 ( -5 ) m ) and dmpp ( 5 x 10 ( -5 ) m ) stimulated the release of norepinephrine greater than the release of epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
79,
93
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
122,
133
]
} |
dmpp produced the same percentage increase in the release of me-irm and norepinephrine but produced a greater percentage increase in the release of me-irm compared to the release of epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
72,
86
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
182,
193
]
} |
there was no apparent correlation between the percentage increase in the release of me-irm and either norepinephrine or epinephrine after ach . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
102,
116
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
120,
131
]
} |
the second fraction was enriched in the 225 000 , 196 000 and 173 000 dalton labeled proteins , the ecm proteins laminin and fibronectin , and the 43 000 actin band . it is proposed that 125i-labeled proteins in the former cell fraction are truly plasma membrane proteins , while those found in the latter cell fraction ... | NA | {
"id": "C0079323",
"name": "ecm proteins",
"pos": [
100,
112
]
} | {
"id": "C0022984",
"name": "laminin",
"pos": [
113,
120
]
} |
the second fraction was enriched in the 225 000 , 196 000 and 173 000 dalton labeled proteins , the ecm proteins laminin and fibronectin , and the 43 000 actin band . it is proposed that 125i-labeled proteins in the former cell fraction are truly plasma membrane proteins , while those found in the latter cell fraction ... | NA | {
"id": "C0079323",
"name": "ecm proteins",
"pos": [
100,
112
]
} | {
"id": "C0016055",
"name": "fibronectin",
"pos": [
125,
136
]
} |
a single intraperitoneal dose of endotoxin ( lipopolysaccharide or lps ) induces an acute inflammatory response in the uveal tract of rats . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
33,
42
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
67,
70
]
} |
colchicine , a naturally occurring alkaloid , inhibits both fast and slow axoplasmic transport by prevention of microtubule assembly . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
0,
10
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
35,
43
]
} |
the concentration of total glutathione ( gsh + gssg ) in the endothelia of these corneas was decreased and the fraction found in the oxidized form was higher than in controls without bcnu . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
41,
44
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
47,
51
]
} |
the intraocular pressure and the pupillary responses in conscious rabbits to racemic erythro-alpha-methylnorepinephrine ( alpha mene ) have been investigated and its activity compared to l-norepinephrine ( ne ) . | NA | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
93,
119
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
189,
203
]
} |
the maximal intraocular pressure response to alpha mene exceeded that to ne , and the sensitivity of the intraocular pressure response exceeded that to ne by 10-20 times . | NA | {
"id": "C0025805",
"name": "alpha mene",
"pos": [
45,
55
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
152,
154
]
} |
the onset of the decrease in intraocular pressure to alpha mene was rapid and contrasted to the slow onset of the intraocular hypotensive response to ne . | NA | {
"id": "C0025805",
"name": "alpha mene",
"pos": [
53,
63
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
150,
152
]
} |
preganglionic cervical sympathotomy did not effect the intraocular pressure and the pupillary responses to either alpha mene or ne . | NA | {
"id": "C0025805",
"name": "alpha mene",
"pos": [
114,
124
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
128,
130
]
} |
the observations are discussed in the light of recent data of the affinities of alpha mene and ne to alpha 1 , alpha 2 , and beta adrenoceptors . | NA | {
"id": "C0025805",
"name": "alpha mene",
"pos": [
80,
90
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
95,
97
]
} |
an additional continuous 8-bromo-cyclic amp infusion during the late period of a continuous trh infusion caused a continuous prl release similar to that induced by the continuous infusion of cyclic amp only . | NA | {
"id": "C0000661",
"name": "8-bromo-cyclic amp",
"pos": [
25,
43
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
191,
201
]
} |
it does not bind with synthetic cooh-terminal peptides nor monosaccharides such as n-acetyl-d-galactosamine and d-galactose , which are sugar components in o-glycosidic carbohydrate chains . | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
59,
74
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
169,
181
]
} |
asialo-hcg immunoactivity was insignificant in all patients with hydatidiform mole , invasive hydatidiform mole and persisted trophoblastic disease . | NA | {
"id": "C0020217",
"name": "hydatidiform mole",
"pos": [
65,
82
]
} | {
"id": "C2931618",
"name": "trophoblastic disease",
"pos": [
126,
147
]
} |
the finding suggested that new substance in addition to insulin and its precursor was present in the insulin secretory granules of the human pancreatic b-cells . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
56,
63
]
} | {
"id": "C0795635",
"name": "insulin",
"pos": [
101,
108
]
} |
in this study serum levels of estetrol ( e4 ) , estetrol glucosiduronate ( e4-g ) , estriol ( e3 ) and estriol-16-glucosiduronate ( e3-16-g ) were measured by r.i.a . in maternal peripheral vein blood ( mpv ) , umbilical artery blood ( ua ) and umbilical vein blood ( uv ) at delivery . | NA | {
"id": "C0014899",
"name": "estetrol",
"pos": [
30,
38
]
} | {
"id": "C0014927",
"name": "estriol",
"pos": [
103,
110
]
} |
lymphocytes of thymus , spleen , peripheral blood ( pb ) and bone marrow ( bm ) collected from adult lizards , chalcides ocellatus were cultured for 24 hr in the presence of 10 ( -3 ) m hydrocortisone acetate ( hc ) in order to assess the effect of in vitro hc on lizard t and b cell viability . | NA | {
"id": "C0063077",
"name": "hydrocortisone acetate",
"pos": [
186,
208
]
} | {
"id": "C0020268",
"name": "hc",
"pos": [
258,
260
]
} |
the responses of mice to h-2d antigens on allogeneic cells and hapten ( fluorescein isothiocyanate ) antigens on syngeneic cells were examined in parallel . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
42,
58
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
123,
128
]
} |
removal of either plastic- , nylon wool- , or carbonyl iron ( cfe ) adherent cells not only removed suppression of background by high con a doses , but also allowed mitogenic responses at adult levels in normally unresponsive 15 to 21 day old pups . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
18,
25
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
29,
34
]
} |
the enzyme exhibited similar kinetic properties to human pi-adh and mouse adh-c2 , previously classified as class ii adhs [ vallee and bazzone ( 1983 ) isozymes , vol . 8 , pp . 219-244 ; algar et al . ( 1983 ) eur . j. biochem . 137 , 139-147 ] but differed in most respects from the extensively investigated horse clas... | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
4,
10
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
152,
160
]
} |
the positively charged cytochrome c lysines 86 and 79 form two from four or five predicted complementary charge interactions with carboxyl groups on cytochrome c oxidase . | NA | {
"id": "C0010749",
"name": "cytochrome c",
"pos": [
23,
35
]
} | {
"id": "C1256752",
"name": "groups",
"pos": [
139,
145
]
} |
nimesulide treatment brought about an immediate and significant improvement in over-all pain , exudation , oedema and headache and produced a rapid lowering in body temperature . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
88,
92
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
118,
126
]
} |
isoenzyme i appears to be the main enzyme in cytosol whereas isoenzyme ii predominates in solubilized microsome and plasma membrane enriched fraction . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
3,
9
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
61,
70
]
} |
after 3 days of e2 , ae , or e2 plus ae treatment , spermidine concentrations are elevated 2-2.5-fold and spermine concentrations are elevated 1.5-fold . | NA | {
"id": "C0037871",
"name": "concentrations",
"pos": [
63,
77
]
} | {
"id": "C0037874",
"name": "concentrations",
"pos": [
115,
129
]
} |
amino acid composition and chemical properties indicated probable structures the same as somatostatin-14 , somatostatin-28 ( 1-12 ) , [ met ( o ) 8 ] somatostatin-28 ( 1-12 ) , [ met ( o ) 8 ] somatostatin-28 ( 1-10 ) , somatostatin-25 ( 1-9 ) and [ met ( o ) 5 ] somatostatin-25 ( 1-9 ) . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
89,
104
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
193,
208
]
} |
the combined use of the broadly reacting aif antibody and the subfamily-specific ae1 and ae3 monoclonal antikeratin antibodies should facilitate the immunological definition , identification , and classification of mammalian epithelial keratins . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
45,
53
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
93,
103
]
} |
the data suggest a possible involvement in heart differentiation that is necessary for either the synthesis of non-actin cardiac contractile proteins or the assembly of cardiac contractile proteins into myofibrils . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
98,
107
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
189,
197
]
} |
although five ketones ( acetone , 2-butanone , 2-pentanone , 2-hexanone , ( hx ) , and 2-heptanone ) increased chcl3-induced kidney and liver injury in male , fischer 344 rats , no relationship between ketone chain length and potentiating capacity was observed . | NA | {
"id": "C0001002",
"name": "acetone",
"pos": [
24,
31
]
} | {
"id": "C0022634",
"name": "ketone",
"pos": [
202,
208
]
} |
metabolism of drugs and xenobiotics by renal mixed-function oxidases and prostaglandin h synthase was examined . | NA | {
"id": "C0020364",
"name": "mixed-function oxidases",
"pos": [
45,
68
]
} | {
"id": "C0033551",
"name": "prostaglandin h synthase",
"pos": [
73,
97
]
} |
prostaglandin h synthase is a potential alternative to mixed-function oxidase activation of chemicals which exert pathologic effects on the renal inner medulla . | NA | {
"id": "C0033551",
"name": "prostaglandin h synthase",
"pos": [
0,
24
]
} | {
"id": "C0020364",
"name": "mixed-function oxidase",
"pos": [
55,
77
]
} |
recently we proposed a topographical classification of myocardial infarction ( mi ) based on the site and extension of left ventricular asynergy ( as ) detected by two-dimensional echocardiography ( 2d echo ) at rest : a ) anterior mi : 1 ) apical mi with as of apical segments only , 2 ) apico-septal mi with as of apex... | NA | {
"id": "C0340293",
"name": "anterior mi",
"pos": [
223,
234
]
} | {
"id": "C0027051",
"name": "mi",
"pos": [
358,
360
]
} |
patients were excluded at the beginning of the study , if they showed sick sinus syndrome , recorded 3rd degree atrioventricular block , angina pectoris , recent myocardial infarction , congenital or surgical cardiac block . | NA | {
"id": "C0004245",
"name": "atrioventricular block",
"pos": [
112,
134
]
} | {
"id": "C0018794",
"name": "cardiac block",
"pos": [
209,
222
]
} |
the drugs tested were : propafenone ( 12 patients ) , amiodarone ( 11 patients ) , ajmaline ( 4 patients ) , tocainide ( 3 patients ) , lorcainide ( 2 patients ) , lorajmine ( 1 patient ) , disopiramide ( 1 patient ) . | NA | {
"id": "C0001888",
"name": "ajmaline",
"pos": [
83,
91
]
} | {
"id": "C0024001",
"name": "lorajmine",
"pos": [
164,
173
]
} |
at the same time , we found that the mortality among newborn with a weight between the fifth and tenth percentile was not significantly higher than that observed among infants with a weight at birth greater than the tenth percentile . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
68,
74
]
} | {
"id": "C0005612",
"name": "weight",
"pos": [
183,
189
]
} |
hence , the only risk involved in amniocentesis which can not be predicted in advance , would be haemorrhage due to injury to a vessel , mainly in the myometrium or , if transplacental puncture becomes necessary , a possible formation of a haematoma leading to abortion . | NA | {
"id": "C0019080",
"name": "haemorrhage",
"pos": [
97,
108
]
} | {
"id": "C0018944",
"name": "haematoma",
"pos": [
240,
249
]
} |
the influence on the platelets of a single large intravenous dose was also tested using eight antimicrobial drugs , viz . benzylpenicillin , ampicillin , carbenicillin , piperacillin , cloxacillin , cefuroxime , cefotaxime and erythromycin . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
122,
138
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
141,
151
]
} |
the influence on the platelets of a single large intravenous dose was also tested using eight antimicrobial drugs , viz . benzylpenicillin , ampicillin , carbenicillin , piperacillin , cloxacillin , cefuroxime , cefotaxime and erythromycin . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
122,
138
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
154,
167
]
} |
the influence on the platelets of a single large intravenous dose was also tested using eight antimicrobial drugs , viz . benzylpenicillin , ampicillin , carbenicillin , piperacillin , cloxacillin , cefuroxime , cefotaxime and erythromycin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
141,
151
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
170,
182
]
} |
the influence on the platelets of a single large intravenous dose was also tested using eight antimicrobial drugs , viz . benzylpenicillin , ampicillin , carbenicillin , piperacillin , cloxacillin , cefuroxime , cefotaxime and erythromycin . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
199,
209
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
212,
222
]
} |
contrary to heparin , higher concentrations of the studied heparinoids strongly potentiated the adp-induced aggregation response . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
12,
19
]
} | {
"id": "C0019142",
"name": "heparinoids",
"pos": [
59,
70
]
} |
less significant changes in the secondary aggregation were observed also after administration of s-heparin ( one of the studied heparinoids ) to volunteers in the form of the rectal suppositories . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
99,
106
]
} | {
"id": "C0019142",
"name": "heparinoids",
"pos": [
128,
139
]
} |
platelet rich plasma ( prp ) was stimulated by addition of epinephrine , norepinephrine , dopamine , dobutamine , adp , collagen or a 23187 in various concentrations . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
59,
70
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
73,
87
]
} |
after adp , epinephrine and norepinephrine the thromboxane formation took place mainly in the late aggregation phase and reached levels of 37-51 ng txb2/ml prp . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
12,
23
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
28,
42
]
} |
we reported previously that the acute and fetal toxicities of aspirin ( asa ) were enhanced by bacterial endotoxin ( lps ) . | NA | {
"id": "C0014264",
"name": "bacterial endotoxin",
"pos": [
95,
114
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
117,
120
]
} |
effect of amantadine , an adamantane derivative , was investigated on intracranial self-stimulation behavior and cerebral glucose utilization ( cgu ) in rats . | NA | {
"id": "C0002403",
"name": "amantadine",
"pos": [
10,
20
]
} | {
"id": "C0001392",
"name": "adamantane",
"pos": [
26,
36
]
} |
in addition to fibroblasts and hofbauer cells , the connective tissue of the fetal membranes contain myofibroblasts . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
15,
26
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
40,
45
]
} |
the second , even more important application of eeg long-term recordings is the special examination of patients with known epilepsy , such as studies of the circadian profiles of epileptic excitability , documentation of seizure frequency , and electrographic analysis of the course of seizure . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
179,
188
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
286,
293
]
} |
the most predominant agag components in normal human liver tissue were heparan sulfates ( hs ) which accounting for 63 % of the total agag , followed by a moderate amount of dermatan sulfate ( ds ) and small amounts of chondroitin sulfate isomers and hyaluronic acid ( ha ) . | NA | {
"id": "C0017973",
"name": "agag",
"pos": [
21,
25
]
} | {
"id": "C0019143",
"name": "heparan sulfates",
"pos": [
71,
87
]
} |
the ratio of non-sulfated agag , ha plus chondroitin , to ds plus its oversulfated isomer was 0.24 in the normal state but it increased to 0.80 at the early stage of liver cirrhosis . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
41,
52
]
} | {
"id": "C0011602",
"name": "ds",
"pos": [
58,
60
]
} |
these data and the fact that naloxone caused a different antagonism of inhibitory effects by these two peptides suggest the existence of two types of opiate receptors on some hypothalamic neurons and that tyr-ile-phe-val preferentially binds to delta-receptors . | NA | {
"id": "C0034801",
"name": "opiate receptors",
"pos": [
150,
166
]
} | {
"id": "C0140057",
"name": "delta-receptors",
"pos": [
245,
260
]
} |
identification of the sialic acids of the novel species by thin-layer chromatography , high performance liquid chromatography and gas-liquid chromatography -- mass spectrometry revealed the presence of both n-acetylneuraminic acid and n-acetyl-9-o-acetyl-neuraminic acid in about equimolar amounts . | NA | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
22,
34
]
} | {
"id": "C0067762",
"name": "n-acetylneuraminic acid",
"pos": [
207,
230
]
} |
with time , ose cells tended to assume a fibroblast-like morphology but remained keratin positive and continued to resemble ose by scanning electron microscopy ( sem ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
16,
21
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
41,
51
]
} |
na+ , k+-atpase , hco3 ( - ) -atpase , ca2+ , mg2+ , -atpase , ca2+-atpase , and alkaline phosphatase activities were measured in cultures of osteoblastlike cells treated with fluoride and cortisol separately and in combinations . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
0,
2
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
68,
74
]
} |
na+ , k+-atpase , hco3 ( - ) -atpase , ca2+ , mg2+ , -atpase , ca2+-atpase , and alkaline phosphatase activities were measured in cultures of osteoblastlike cells treated with fluoride and cortisol separately and in combinations . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
9,
15
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
63,
66
]
} |
lipopolysaccharide ( lps ) , the active component of bacterial endotoxin , caused no significant increase in ornithine decarboxylase ( odc ) activity in serum-starved , chinese hamster ovary fibroblasts . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
0,
18
]
} | {
"id": "C0014264",
"name": "bacterial endotoxin",
"pos": [
53,
72
]
} |
rabbits immunized with purified sm and rnp small nuclear ribonucleoproteins ( snrnps ) produced precipitating and hemagglutinating antibodies against these antigens . | NA | {
"id": "C0035544",
"name": "rnp",
"pos": [
39,
42
]
} | {
"id": "C0142661",
"name": "small nuclear ribonucleoproteins",
"pos": [
43,
75
]
} |
precipitation by 50 % final saturation of ammonium sulphate , a method commonly used to estimate titres and affinity constants of antibodies , was found consistently to overestimate the titre of anti-peptide antisera when compared with other antibody precipitants . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
208,
216
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
242,
250
]
} |
these monoclonal antibodies did not recognize either angiotensin peptides or angiotensinogen from other species , except for mouse angiotensinogen , which cross-reacted with the different antibodies from 0 to 25 % . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
6,
16
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
188,
198
]
} |
these monoclonal antibodies did not recognize either angiotensin peptides or angiotensinogen from other species , except for mouse angiotensinogen , which cross-reacted with the different antibodies from 0 to 25 % . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
53,
64
]
} | {
"id": "C0003017",
"name": "angiotensinogen",
"pos": [
131,
146
]
} |
a depletion in heavy metal ( zinc ) in these cells was also evident after treatment with streptozotocin . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
15,
26
]
} | {
"id": "C0043481",
"name": "zinc",
"pos": [
29,
33
]
} |
the two glycoproteins contained hydroxyproline , high amounts of glycine , and other amino acids in amounts comparable to those present in the same two glycoproteins isolated from lung lavage of patients with alveolar proteinosis . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
65,
72
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
85,
96
]
} |
developmental aspects of ideational fluency , flexibility , and originality were assessed across five age groups ( children , adolescents , young adults , adults , middle-aged adults ) comparatively in two cultures ( chinese and american ) . | NA | {
"id": "C0001675",
"name": "adults",
"pos": [
146,
152
]
} | {
"id": "C0683973",
"name": "middle-aged adults",
"pos": [
164,
182
]
} |
adrenoleukodystrophy ( ald ) is a fatal x-linked recessive lipid storage disease characterized by progressive cns demyelination and adrenal insufficiency . | NA | {
"id": "C0162309",
"name": "ald",
"pos": [
23,
26
]
} | {
"id": "C0001623",
"name": "adrenal insufficiency",
"pos": [
132,
153
]
} |
application of the israel ischemic heart disease study data to these findings could predict only a very slight decrease in the 5-year estimated probability of myocardial infarction in the chlorthalidone-treated group . | NA | {
"id": "C0151744",
"name": "of the",
"pos": [
12,
18
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
159,
180
]
} |
in addition , where the mother showed significant sensitization to paternal hla-a , -b antigens ther was no apparent selection against the incompatible paternal hla antigens or associated haplotypes in subsequent offspring . | NA | {
"id": "C0019728",
"name": "hla-a",
"pos": [
76,
81
]
} | {
"id": "C0019721",
"name": "hla antigens",
"pos": [
161,
173
]
} |
these included cardiac hypertrophy , reduced urinary catecholamine excretion during and after stress situations , increased tail skin temperature response to isoproterenol , and a higher tail skin temperature during exposure to cold . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
53,
66
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
158,
171
]
} |
ceftiolene ( 42980rp ) is a new cephalosporin with a broad antibacterial spectrum similar to cefotaxime or ceftriaxone . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
93,
103
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
107,
118
]
} |
the affinities of ceftiolene for penicillin-binding proteins were very comparable with those of ceftriaxone and cefotaxime for escherichia coli , and generally greater than those of latamoxef ( moxalactam ) for the higher molecular weight pbps of e. coli . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
96,
107
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
112,
122
]
} |
chloramphenicol was less antagonistic against ceftiolene- or ceftriaxone-induced lysis than was observed for cefotaxime or latamoxef . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
61,
72
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
109,
119
]
} |
the antibiotics most commonly associated with cl . difficile enterocolitis ( cde ) were penicillins , cephalosporins and clindamycin/lincomycin . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
121,
132
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
133,
143
]
} |
on the basis of consumption clindamycin/lincomycin and cephalosporins are associated 70 and 40 times , respectively , more often than penicillins in cde . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
28,
39
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
40,
50
]
} |
an immunoassay for detection of the enterotoxin ( toxin a ) of cl . difficile seems to be a useful alternative to the cytotoxin assay , but some stool specimens with a low toxin b titre were negative . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
36,
47
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
172,
177
]
} |
pronase , proteinase k , carboxypeptidases a and b , aminopeptidase m , intestinal mucosa exopeptidases and prolidase , immobilized to derivatized controlled-pore glass beads , were used in a study of total enzymic hydrolysis of proteins . | NA | {
"id": "C0007075",
"name": "carboxypeptidases",
"pos": [
25,
42
]
} | {
"id": "C0117059",
"name": "exopeptidases",
"pos": [
90,
103
]
} |
( i ) activity recovery after the immobilization was very high , ( ii ) enzyme proteins in crude enzyme preparation could be immobilized specifically , and ( iii ) immobilized enzymes could be replaced easily by fresh enzyme proteins through a urea-buffer treatment . | NA | {
"id": "C0014444",
"name": "immobilized",
"pos": [
125,
136
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
218,
224
]
} |
after extraction and preliminary cleanup chromatography with n-hexane or chloroform , the mycotoxins ochratoxin a , citrinin , penicillic acid , sterigmatocystin , and zearalenone were easily separated by thin layer chromatography ( tlc ) using toluene-ethyl acetate-90 % formic acid ( 6 + 3 + 1 ) developing solvent . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
90,
100
]
} | {
"id": "C0038274",
"name": "sterigmatocystin",
"pos": [
145,
161
]
} |
the overall repeatability and reproducibility standard deviations for commercial tablets were 1.11 and 1.75 % for methyldopa , 0.96 and 1.62 % for chlorothiazide , and 1.21 and 2.15 % for hydrochlorothiazide , respectively . | NA | {
"id": "C0008273",
"name": "chlorothiazide",
"pos": [
147,
161
]
} | {
"id": "C0020261",
"name": "hydrochlorothiazide",
"pos": [
188,
207
]
} |
the overall recoveries of methyldopa , chlorothiazide , and hydrochlorothiazide added to synthetic tablets were 100.78 , 100.70 , and 101.34 % , respectively . | NA | {
"id": "C0008273",
"name": "chlorothiazide",
"pos": [
39,
53
]
} | {
"id": "C0020261",
"name": "hydrochlorothiazide",
"pos": [
60,
79
]
} |
a simple and rapid method was developed for quantitative determination of common tetracyclines , such as oxytetracycline ( otc ) , tetracycline ( tc ) , and chlortetracycline ( ctc ) , in meat and fish . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
81,
94
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
105,
120
]
} |
a simple and rapid method was developed for quantitative determination of common tetracyclines , such as oxytetracycline ( otc ) , tetracycline ( tc ) , and chlortetracycline ( ctc ) , in meat and fish . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
81,
94
]
} | {
"id": "C0008293",
"name": "chlortetracycline",
"pos": [
157,
174
]
} |
the results of structural studies with methylation and nmr analyses on the native phg and some of its specifically degraded products obtained on partial acid hydrolysis and acetolysis indicate that the polysaccharide moiety of the phg has an ( alpha 1-6 ) linked mannan backbone with mainly ( alpha 1-2 ) linked side cha... | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
202,
216
]
} | {
"id": "C0024727",
"name": "mannan",
"pos": [
263,
269
]
} |
upg i and upg ii were the same in molecular weight ( 3.9 x 10 ( 4 ) ) and in n-terminal ( leucine ) and c-terminal ( alanine ) amino acid residues . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
117,
124
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
127,
137
]
} |
in addition to histones , both the isoenzymes can as well cause dephosphorylation of protamine , casein , and testicular nuclear proteins . | NA | {
"id": "C0019652",
"name": "histones",
"pos": [
15,
23
]
} | {
"id": "C0028589",
"name": "nuclear",
"pos": [
121,
128
]
} |
in addition to histones , both the isoenzymes can as well cause dephosphorylation of protamine , casein , and testicular nuclear proteins . | NA | {
"id": "C0033603",
"name": "protamine",
"pos": [
85,
94
]
} | {
"id": "C0028589",
"name": "nuclear",
"pos": [
121,
128
]
} |
adenovirus 2 major late promoter was utilized more efficiently when integrated into circular plasmid dna than when integrated into truncated dna , as shown by s1 nuclease analysis . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
84,
92
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
141,
144
]
} |
the name cystatin s has been proposed for this salivary protein in view of the similarities in activity and structure to other cysteine proteinase inhibitors such as chicken egg-white cystatin and human cystatins a , b , and c . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
56,
63
]
} | {
"id": "C0010646",
"name": "cystatins",
"pos": [
203,
212
]
} |
the alpha-glucosidase showed relatively high activity not only toward maltose but also toward alpha-glucans , such as soluble starch , beta-limit dextrin , amylopectin , shellfish glycogen , and amylose . | NA | {
"id": "C0017696",
"name": "glucans",
"pos": [
100,
107
]
} | {
"id": "C0038179",
"name": "starch",
"pos": [
126,
132
]
} |
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