text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the measurement of evlw was also of much help in the differential diagnosis of pulmonary edema and other lung diseases . | NA | {
"id": "C0034063",
"name": "pulmonary edema",
"pos": [
79,
94
]
} | {
"id": "C0024115",
"name": "lung",
"pos": [
105,
109
]
} |
consumption of amino acid , arginine , was common to all cell lines and accumulation of glycine and amino acids constituting urea cycle was also common . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
88,
95
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
100,
111
]
} |
furthermore , our results indicated that infected cells , like normal fibroblasts , contain two deoxyguanosine kinase activities , one of mitochondrial and another of cytosolic origin . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
70,
81
]
} |
dynamic systems , modelling the elementary act of nucleophilic attack on the carbonyl carbon atom of amide ( n-methyl-acetamide ) and ester ( methylacetate ) substrates by some compounds , simulating the nucleophilic group of various types proteases active site were calculated and analysed by the cndo/2 method , namely... | NA | {
"id": "C0013879",
"name": "elementary",
"pos": [
32,
42
]
} | {
"id": "C0007009",
"name": "carbon",
"pos": [
86,
92
]
} |
the data reported in this paper demonstrate that macrophage-activating factors ( mafs ) are a heterogeneous group of t-cell-derived lymphokines . | NA | {
"id": "C0079786",
"name": "macrophage-activating factors",
"pos": [
49,
78
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
132,
143
]
} |
preoperative parameters were : age , birth weight ( newborns ) , weight , body temperature , red and white blood count , electrolytes , urea-nitrogen , total serum protein , ph , po2 , pco2 and base excess . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
37,
49
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
65,
71
]
} |
in newborns a statistically significant difference between both groups was found for birth weight , rectal temperature , ph and total serum protein , whereas in children beyond the newborn age the same was true for age , weight and total serum protein . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
85,
97
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
221,
227
]
} |
there were total enhancement of epidural hematoma ( 2 cases ) , partial enhancement of hematoma ( 2 cases ) and enhancement of internal margin of hematoma ( 2 cases ) . | NA | {
"id": "C0238154",
"name": "epidural hematoma",
"pos": [
32,
49
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
146,
154
]
} |
at the bilateral decompressive craniectomies with infusion of 5 gram of fibrinogen and 300 ml of fresh blood , we found neither scalp hemorrhage nor skull fracture and after removal of coagulated hematomas no dural anomaly was found . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
134,
144
]
} | {
"id": "C0018944",
"name": "hematomas",
"pos": [
196,
205
]
} |
the picture included hypokalemic myopathy , with myoglobinuria , an increase in serum enzymes related by rhabdomyolysis , and flaccid paralysis . | NA | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
49,
62
]
} | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
105,
119
]
} |
the effects of some conformationally restricted analogues of gamma-aminobutyric acid ( gaba ) on [ 3h ] ( - ) -baclofen binding indicated that gaba interacts with ( - ) -baclofen-sensitive binding sites ( gabab ) in extended rather than folded conformations , and that folded analogues of gaba may interact with a class ... | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
111,
119
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
338,
342
]
} |
the dithiocarbamates -- sodium diethyldithiocarbamate ( dedtc ) , tetraethylthiuram disulphide ( disulfiram ) , sodium dimethyldithiocarbamate ( dmdtc ) and tetramethylthiuram disulphide ( thiram ) -- were administered perorally in doses of 2 mmol/kg . | NA | {
"id": "C0012422",
"name": "dimethyldithiocarbamate",
"pos": [
119,
142
]
} | {
"id": "C0039962",
"name": "thiram",
"pos": [
189,
195
]
} |
at 72 h the brain concentration of lead in rats administered thiram , dmdtc , disulfiram or dedtc was 100 , 15 , 10 , and 4 times higher respectively , than in controls . | NA | {
"id": "C0039962",
"name": "thiram",
"pos": [
61,
67
]
} | {
"id": "C0012422",
"name": "dmdtc",
"pos": [
70,
75
]
} |
fecal excretion at 72 h in dedtc and dmdtc-treated rats was about 25 % and in thiram and disulfiram-treated rats about 7 % of the dose . | NA | {
"id": "C0012422",
"name": "dmdtc",
"pos": [
37,
42
]
} | {
"id": "C0039962",
"name": "thiram",
"pos": [
78,
84
]
} |
the total urinary excretion of lead at 72 h was about 9 % of the dose in controls , 5 % in the dedtc and dmdtc-treated groups and about 1 % in the thiram and disulfiram-treated groups . | NA | {
"id": "C0012422",
"name": "dmdtc",
"pos": [
105,
110
]
} | {
"id": "C0039962",
"name": "thiram",
"pos": [
147,
153
]
} |
the acute retinal necrosis ( arn ) syndrome is a severe necrotic peripheral retinitis with vasculitis and vitritis . | NA | {
"id": "C0035319",
"name": "acute retinal necrosis",
"pos": [
4,
26
]
} | {
"id": "C0035333",
"name": "retinitis",
"pos": [
76,
85
]
} |
using two antisera with some overlapping specificities , and quantitative immunofluorescent antibody technique ( qifat ) , we determined the concentrations of igg needed to place equivalent amounts of igg on the sporocysts . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
10,
18
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
92,
100
]
} |
metabolism was the main contributor to the elimination of tmp at all ages , although the major metabolic pathway , o-demethylation and subsequent conjugation , was only slightly developed at birth . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
0,
10
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
43,
54
]
} |
cholesterol ester and triglyceride metabolism in intact fibroblasts from patients with wolman 's disease and cholesterol ester storage disease . | NA | {
"id": "C0043208",
"name": "wolman 's disease",
"pos": [
87,
104
]
} | {
"id": "C0008384",
"name": "cholesterol ester storage disease",
"pos": [
109,
142
]
} |
comparison of the effects of betamethasone and l-carnitine on dipalmitoylphosphatidylcholine content and phosphatidylcholine species composition in fetal rat lungs . | NA | {
"id": "C0000039",
"name": "dipalmitoylphosphatidylcholine",
"pos": [
62,
92
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
105,
124
]
} |
on the other hand , no effect of l-carnitine could be demonstrated on the dppc portion in the total phosphatidylcholine ( pc ) or on the portion of palmitic acid in the pc fatty acids . | NA | {
"id": "C0000039",
"name": "dppc",
"pos": [
74,
78
]
} | {
"id": "C1959616",
"name": "pc",
"pos": [
169,
171
]
} |
the portion of dppc in the pc species increased significantly ( p less than 0.01 ) from 27.6 +/- 4.5 in the fetal lungs of the control group to 34.2 +/- 3.3 in the lungs of the betamethasone-treated group , while the palmitic acid portion in the pc fatty acids was nearly unchanged ( 45.9 +/- 3.2 versus 43.9 +/- 2.6 in ... | NA | {
"id": "C0000039",
"name": "dppc",
"pos": [
15,
19
]
} | {
"id": "C1959616",
"name": "pc",
"pos": [
246,
248
]
} |
in order to discriminate among potential etiologies , we asked whether the expression of the mottled mutation causes abnormalities in the metabolism of trace metals other than copper in hemizygous mottled ( blotchy ) cultured skin fibroblasts , and whether we can differentiate mutant and normal cells according to their... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
231,
242
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
289,
295
]
} |
blotchy fibroblasts accumulated up to 12 times more 64cu than control ( littermate ) cells , over time and over a range of 64cu concentrations . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
8,
19
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
85,
90
]
} |
of the apr , c-reactive protein responds most rapidly , but alpha 1-acid glycoprotein ( orosomucoid ) , haptoglobin and mini-esr ( greater than or equal to 15 mm/h ) are also useful . | NA | {
"id": "C0001347",
"name": "apr",
"pos": [
7,
10
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
13,
31
]
} |
of the apr , c-reactive protein responds most rapidly , but alpha 1-acid glycoprotein ( orosomucoid ) , haptoglobin and mini-esr ( greater than or equal to 15 mm/h ) are also useful . | NA | {
"id": "C0001347",
"name": "apr",
"pos": [
7,
10
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
88,
99
]
} |
of the apr , c-reactive protein responds most rapidly , but alpha 1-acid glycoprotein ( orosomucoid ) , haptoglobin and mini-esr ( greater than or equal to 15 mm/h ) are also useful . | NA | {
"id": "C0001347",
"name": "apr",
"pos": [
7,
10
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
104,
115
]
} |
terminal structures of f2 , a linear dna plasmid from yeast : two different terminal structures in one linear dna molecule . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
6,
7
]
} | {
"id": "C0012854",
"name": "dna molecule",
"pos": [
110,
122
]
} |
the enzyme kinetic studies with endonucleases specific for single-stranded dna and the thermal denaturation analyses of dna showed that a high mobility group ( hmg ) nonhistone protein fraction hmg ( 1 + 2 ) , composed of hmg1 and hmg2 , has an activity to unwind dna partially at low protein-to-dna weight ratio . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
59,
78
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
296,
299
]
} |
new types of strong hydrogen bonding interactions between an amino acid and polynucleotides , nucleotides , nucleosides , and nucleic acid bases in aqueous solution have also been detected . | NA | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
76,
91
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
94,
105
]
} |
the kidney and liver showed the high uptake and rapid clearance which was due to the metabolism and excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
85,
95
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
100,
109
]
} |
reactions of chloro ( alkoxycarbonyl ) methylenetriphenylphosphoranes with protected d-ribofuranoses resulted in the exclusive formation of c-beta-d-ribofuranosyl glycosides , which were converted to some c-nucleosides , such as showdomycin and pyrido- [ 1,2-a ] pyrimidine c-nucleosides . | NA | {
"id": "C0017977",
"name": "glycosides",
"pos": [
163,
173
]
} | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
276,
287
]
} |
reactions of chloro ( alkoxycarbonyl ) methylenetriphenylphosphoranes with protected d-ribofuranoses resulted in the exclusive formation of c-beta-d-ribofuranosyl glycosides , which were converted to some c-nucleosides , such as showdomycin and pyrido- [ 1,2-a ] pyrimidine c-nucleosides . | NA | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
207,
218
]
} | {
"id": "C0034287",
"name": "pyrimidine",
"pos": [
263,
273
]
} |
renal tumors most commonly found in this age constitute of two groups which have a better and worse prognosis , respectively , than typical nephroblastomas . | NA | {
"id": "C0022665",
"name": "renal tumors",
"pos": [
0,
12
]
} | {
"id": "C0027708",
"name": "nephroblastomas",
"pos": [
140,
155
]
} |
[ modification of adrenaline and noradrenaline levels by stress in air and oxygen breathing in patients with chronic obstructive ventilation disorders ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
18,
28
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
33,
46
]
} |
this policy was implemented in six pregnancies complicated by fetal gastroschisis without severe associated anomalies which were identified in the second trimester and continued to term . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
35,
46
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
147,
163
]
} |
animals ( rats ) trained to discriminate 1.0 mg/kg of s ( + ) -amphetamine sulfate from saline , using a standard operant training procedure , were administered doses of various amphetamine analogs in tests of stimulus generalization in order to study structure-activity relationships ( sar ) . | NA | {
"id": "C0282051",
"name": "amphetamine sulfate",
"pos": [
63,
82
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
178,
189
]
} |
( a ) the heavy metals , ( b ) the essential and questionable essential trace elements , ( c ) the macrominerals , ( d ) the alkali metals , ( e ) elements used as therapeutic agents , and ( f ) miscellaneous elements . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
10,
22
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
209,
217
]
} |
( a ) the heavy metals , ( b ) the essential and questionable essential trace elements , ( c ) the macrominerals , ( d ) the alkali metals , ( e ) elements used as therapeutic agents , and ( f ) miscellaneous elements . | NA | {
"id": "C0025554",
"name": "alkali",
"pos": [
125,
131
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
209,
217
]
} |
evaluation of the nutrient content of certain diets in regions with low incidence of cancer has advanced the use of certain alkali metals , i.e. , rubidium and cesium , as chemotherapeutic agents . | NA | {
"id": "C0025554",
"name": "alkali metals",
"pos": [
124,
137
]
} | {
"id": "C0035930",
"name": "rubidium",
"pos": [
147,
155
]
} |
evaluation of the nutrient content of certain diets in regions with low incidence of cancer has advanced the use of certain alkali metals , i.e. , rubidium and cesium , as chemotherapeutic agents . | NA | {
"id": "C0025554",
"name": "alkali metals",
"pos": [
124,
137
]
} | {
"id": "C0007886",
"name": "cesium",
"pos": [
160,
166
]
} |
the alkali metals from the group ia of the periodic table ( lithium , sodium , potassium , rubidium , cesium and francium ) are reviewed . | NA | {
"id": "C0025554",
"name": "alkali metals",
"pos": [
4,
17
]
} | {
"id": "C0023870",
"name": "lithium",
"pos": [
60,
67
]
} |
the alkali metals from the group ia of the periodic table ( lithium , sodium , potassium , rubidium , cesium and francium ) are reviewed . | NA | {
"id": "C0025554",
"name": "alkali metals",
"pos": [
4,
17
]
} | {
"id": "C0037473",
"name": "sodium",
"pos": [
70,
76
]
} |
the alkali metals from the group ia of the periodic table ( lithium , sodium , potassium , rubidium , cesium and francium ) are reviewed . | NA | {
"id": "C0025554",
"name": "alkali metals",
"pos": [
4,
17
]
} | {
"id": "C0032821",
"name": "potassium",
"pos": [
79,
88
]
} |
the alkali metals from the group ia of the periodic table ( lithium , sodium , potassium , rubidium , cesium and francium ) are reviewed . | NA | {
"id": "C0025554",
"name": "alkali metals",
"pos": [
4,
17
]
} | {
"id": "C0035930",
"name": "rubidium",
"pos": [
91,
99
]
} |
the alkali metals from the group ia of the periodic table ( lithium , sodium , potassium , rubidium , cesium and francium ) are reviewed . | NA | {
"id": "C0025554",
"name": "alkali metals",
"pos": [
4,
17
]
} | {
"id": "C0007886",
"name": "cesium",
"pos": [
102,
108
]
} |
the alkali metal ions lithium , potassium , rubidium and cesium depress the rate of spontaneous beating of isolated rabbit right atria . | NA | {
"id": "C0025554",
"name": "alkali metal",
"pos": [
4,
16
]
} | {
"id": "C0023870",
"name": "lithium",
"pos": [
22,
29
]
} |
the alkali metal ions lithium , potassium , rubidium and cesium depress the rate of spontaneous beating of isolated rabbit right atria . | NA | {
"id": "C0025554",
"name": "alkali metal",
"pos": [
4,
16
]
} | {
"id": "C0032821",
"name": "potassium",
"pos": [
32,
41
]
} |
the alkali metal ions lithium , potassium , rubidium and cesium depress the rate of spontaneous beating of isolated rabbit right atria . | NA | {
"id": "C0025554",
"name": "alkali metal",
"pos": [
4,
16
]
} | {
"id": "C0035930",
"name": "rubidium",
"pos": [
44,
52
]
} |
the alkali metal ions lithium , potassium , rubidium and cesium depress the rate of spontaneous beating of isolated rabbit right atria . | NA | {
"id": "C0025554",
"name": "alkali metal",
"pos": [
4,
16
]
} | {
"id": "C0007886",
"name": "cesium",
"pos": [
57,
63
]
} |
the drug , even at micromolar concentration , showed a significant stimulatory effect on ca++/mg++- atpase , ca++- atpase and adenylate cyclase activities . | NA | {
"id": "C0001477",
"name": "ca",
"pos": [
62,
64
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
115,
121
]
} |
nucleotide sequence analysis of an antigen found on the surface of cells infected with ring stage parasites revealed an unusual sequence coding for eight , four and three amino acid repeats rich in acidic amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
171,
181
]
} | {
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
198,
216
]
} |
we have cloned a set of seven cdnas corresponding to mrnas induced by type i interferon in human cells , and are using these probes to characterize the response to interferon in detail . | NA | {
"id": "C0021743",
"name": "type i",
"pos": [
70,
76
]
} | {
"id": "C0021747",
"name": "interferon",
"pos": [
164,
174
]
} |
we have introduced into murine erythroleukaemia ( mel ) cells a series of human globin gene cosmids and two sets of hybrid genes constructed from the human beta-globin gene and the human gamma-globin or murine h-2kbm1 genes . | NA | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
156,
167
]
} | {
"id": "C0017033",
"name": "gamma-globin",
"pos": [
187,
199
]
} |
s1-nuclease analysis of the mrna products from these genes before and after mel cell differentiation showed that the human beta-globin gene , but not the human epsilon- or gamma-globin or h-2kbm1 genes , is induced specifically . | NA | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
123,
134
]
} | {
"id": "C0017033",
"name": "gamma-globin",
"pos": [
172,
184
]
} |
the effect of stimulation of the medial surface of the cerebral cortex on the intake of sodium chloride ( nacl ) solution was studied in male rats which were depleted of sodium by peritoneal dialysis ( p.d . ) . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
95,
103
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
106,
110
]
} |
however , a small but significant sex difference in bwt persists in animals gonadectomized at birth , indicating that early hormonal exposure may permanently influence certain steroid sensitive weight regulatory mechanisms in the two sexes . | NA | {
"id": "C0005911",
"name": "difference",
"pos": [
38,
48
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
194,
200
]
} |
therefore , although gps show only minor sex differences in bwt which might relate to prenatal gonadal hormonal exposure , significant sex differences remain in their responsiveness to the activational effects of gonadal steroids on fi and bwt in adulthood . | NA | {
"id": "C0005911",
"name": "differences",
"pos": [
45,
56
]
} | {
"id": "C0005910",
"name": "bwt",
"pos": [
240,
243
]
} |
influence of dietary protein level on protein self-selection and plasma and brain amino acid concentrations . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
13,
28
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
38,
45
]
} |
platelet serotonin levels were measured in several psychiatric disorders to determine whether they distinguish among major depressive disorder ( one or more depressive episodes and no manic episodes ) , dysthymic disorder ( depressive neurosis ) , and schizophrenic and paranoid disorders . | NA | {
"id": "C0013415",
"name": "dysthymic disorder",
"pos": [
203,
221
]
} | {
"id": "C0011581",
"name": "depressive",
"pos": [
224,
234
]
} |
the anthracenedione antineoplastic agents ametantrone ( haq ) and mitoxantrone are potent antioxidants and inhibit hydroperoxide-dependent initiation and propagation reactions . | NA | {
"id": "C0003174",
"name": "anthracenedione",
"pos": [
4,
19
]
} | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
66,
78
]
} |
[ analysis of cases of dermatomycoses with reference to zoonotic mycoses in railway workers treated at the research center of the railway health service 1978-1982 ] . | NA | {
"id": "C0011630",
"name": "dermatomycoses",
"pos": [
23,
37
]
} | {
"id": "C0026946",
"name": "mycoses",
"pos": [
65,
72
]
} |
radioimmunoassays were developed for the tachykinins eledoisin ( ele ) and kassinin ( kas ) using antisera raised in rabbits . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
41,
52
]
} | {
"id": "C0022528",
"name": "kassinin",
"pos": [
75,
83
]
} |
radioimmunoassays based on antisera raised against the tachykinins eledoisin ( antiserum e7 ) and kassinin ( antiserum k12 ) were used to measure the concentration of tachykinin-like immunoreactivity ( tkli ) in plasma from 52 healthy subjects . | NA | {
"id": "C0022528",
"name": "kassinin",
"pos": [
98,
106
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
167,
177
]
} |
tachykinin immunoreactive material detected in tumor tissue and plasma of patients with carcinoid tumor may play a role in the symptomatology of the carcinoid syndrome . | NA | {
"id": "C0007095",
"name": "carcinoid tumor",
"pos": [
88,
103
]
} | {
"id": "C0024586",
"name": "carcinoid syndrome",
"pos": [
149,
167
]
} |
[ calcium , inorganic phosphates and nucleotides in the saliva of patients with periodontal diseases and gingivitis ] . | NA | {
"id": "C0017563",
"name": "periodontal diseases",
"pos": [
80,
100
]
} | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
105,
115
]
} |
the time to reach peak serum cortisol concentrations was variable , however , and occurred sooner after cosyntropin ( 30 to 60 minutes ) than after acth gel administration ( 90 to 180 minutes ) . | NA | {
"id": "C0010192",
"name": "cosyntropin",
"pos": [
104,
115
]
} | {
"id": "C0001655",
"name": "acth",
"pos": [
148,
152
]
} |
based on the time response studies , post acth cortisol samples should be collected 60 to 90 minutes after cosyntropin or 90 to 120 minutes after acth gel injection to ensure detection of peak adrenocortical response with either acth preparation . | NA | {
"id": "C0010192",
"name": "cosyntropin",
"pos": [
107,
118
]
} | {
"id": "C0001655",
"name": "acth preparation",
"pos": [
229,
245
]
} |
[ influence of aging on the function of the sympathetic nervous system in healthy subjects -- plasma norepinephrine , epinephrine and dopamine levels in rest and changes of posture ] . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
101,
115
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
118,
129
]
} |
in the present study we investigated the effects of dids ( 4,4'-diisothiocyano-disulfonic stilbene ) , a known inorganic anion exchange blocker , on csf ionic regulation in acute respiratory acidosis . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
121,
126
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
153,
158
]
} |
plasma concentrations of epinephrine and norepinephrine in the variant angina group showed higher values than those in the effort angina group and the old myocardial infarction group . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
25,
36
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
41,
55
]
} |
after the structures of pyrethrins , the insecticidal components of pyrethrum flowers , were determined , syntheses of derivatives of them were undertaken , and first generation synthetic pyrethroids , such as allethrin , resmethrin and phenothrin , were produced . | NA | {
"id": "C0034245",
"name": "pyrethrins",
"pos": [
24,
34
]
} | {
"id": "C0002119",
"name": "allethrin",
"pos": [
210,
219
]
} |
group 2 was made up of 9 classical syndromes of aphasia : 2 global aphasias , 3 broca 's aphasias , 3 cases of wernicke 's aphasia and 1 case of conduction aphasia . | NA | {
"id": "C0003537",
"name": "syndromes",
"pos": [
35,
44
]
} | {
"id": "C1510456",
"name": "wernicke 's aphasia",
"pos": [
111,
130
]
} |
group 2 was made up of 9 classical syndromes of aphasia : 2 global aphasias , 3 broca 's aphasias , 3 cases of wernicke 's aphasia and 1 case of conduction aphasia . | NA | {
"id": "C0003537",
"name": "syndromes",
"pos": [
35,
44
]
} | {
"id": "C0234471",
"name": "conduction aphasia",
"pos": [
145,
163
]
} |
a new cephalosporin , cefonicid ( 1 g ) , was given intramuscularly to 49 patients 1 hr before they were to undergo surgery and to 10 healthy lactating women . | NA | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
6,
19
]
} | {
"id": "C0007551",
"name": "cefonicid",
"pos": [
22,
31
]
} |
the three substances bromhexine , na 872 ( bromhexine metabolite viii ) and the beta 2-receptor agonist nab 365 ( clenbuterol ) and their effect on the mucociliary activity have been studied in vivo in rabbits . | NA | {
"id": "C0006220",
"name": "bromhexine",
"pos": [
21,
31
]
} | {
"id": "C0002421",
"name": "bromhexine metabolite viii",
"pos": [
43,
69
]
} |
the hypercalcemia could be due to a `` '' parathormone like '' '' substance , to prostaglandins , to a substance that stimulates osteoclasts ( oaf ) , or to calcitriol ( 1,25-dihydroxycholecalciferol ) . | NA | {
"id": "C0006674",
"name": "calcitri",
"pos": [
157,
165
]
} | {
"id": "C0012328",
"name": "5-dihydroxycholecalcifer",
"pos": [
173,
197
]
} |
crystal deposition follows a defined series of events including changes in ca : mg : pi ratios , membrane lipids , pr concentration , protein and phospholipid composition , and mineral phase . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
97,
112
]
} | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
146,
158
]
} |
in contrast , factor xiif-induced hypotension was not enhanced by blockade of the renin-angiotensin system by saralasin , a competitive antagonist of angiotensin ii at the vascular receptor level . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
110,
119
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
150,
164
]
} |
in the acute stage it was impossible to distinguish clinically between abdominal wall bleeding and intraperitoneal bleeding . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
86,
94
]
} | {
"id": "C0019065",
"name": "intraperitoneal bleeding",
"pos": [
99,
123
]
} |
on three days ( day 1 , day 21 , day 42 ) the influence of alcohol on the major lipoprotein density classes ( i.e . very low-density lipoproteins [ vldl ] , intermediate-density lipoproteins [ idl ] , low-density lipoproteins [ ldl ] , hdl2 and hdl3 , all by means of rate zonal ultracentrifugation ) and on postheparin ... | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
80,
91
]
} | {
"id": "C0023825",
"name": "very low-density lipoproteins",
"pos": [
116,
145
]
} |
on three days ( day 1 , day 21 , day 42 ) the influence of alcohol on the major lipoprotein density classes ( i.e . very low-density lipoproteins [ vldl ] , intermediate-density lipoproteins [ idl ] , low-density lipoproteins [ ldl ] , hdl2 and hdl3 , all by means of rate zonal ultracentrifugation ) and on postheparin ... | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
80,
91
]
} | {
"id": "C0065063",
"name": "intermediate-density lipoproteins",
"pos": [
157,
190
]
} |
when combined with penicillin , sulbactam , a beta-lactamase inhibitor with weak intrinsic antibacterial activity , produces a marked synergistic effect in vitro against penicillinase-producing neisseria gonorrhoeae . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
19,
29
]
} | {
"id": "C0038665",
"name": "sulbactam",
"pos": [
32,
41
]
} |
of 101 patients receiving the penicillin-sulbactam regimen , 97 ( 97 % ) were cured of their infection , as were 87 ( 95 % ) of 92 patients who received spectinomycin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
30,
40
]
} | {
"id": "C0038665",
"name": "sulbactam",
"pos": [
41,
50
]
} |
43 ( 94 % ) of 46 treated with the penicillin-sulbactam regimen were cured as compared with 47 ( 92 % ) of 51 treated with spectinomycin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
35,
45
]
} | {
"id": "C0038665",
"name": "sulbactam",
"pos": [
46,
55
]
} |
on the other hand , thiamphenicol does not appear to be associated with the dose-unrelated , delayed type of hemotoxicity known to occur after therapy with chloramphenicol . | NA | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
20,
33
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
156,
171
]
} |
the comparative effects of chloramphenicol , its nitroso derivative , and thiamphenicol on a number of metabolic parameters in vitro , including dna and mitochondrial protein synthesis , and the effects of these agents on isolated double-stranded dna are described . | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
27,
42
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
74,
87
]
} |
in 52 ( 48.1 % ) of the patients with aplastic anemia , the following etiologic factors were implicated : benzene ( 25 patients ) , antirheumatic drugs ( ten ) , chloramphenicol ( four ) , chloramphenicol plus hepatitis or chromosome anomalies ( two ) , thiamphenicol plus sulfonamide ( one ) , antituberculous drugs ( t... | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
162,
177
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
254,
267
]
} |
the activity of thiamphenicol , an analogue of chloramphenicol without a nitro group , was compared with that of chloramphenicol against anaerobic bacteria . | NA | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
16,
29
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
113,
128
]
} |
chloramphenicol exhibited slightly greater activity than thiamphenicol in vitro , but the difference was too small to be of potential clinical significance . | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
0,
15
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
57,
70
]
} |
all animals were decapitated after the last injection and trunk plasma was assayed for prolactin , beta-endorphin-like immunoreactivity ( beta-end li ) , norepinephrine ( ne ) , epinephrine ( e ) , dihydroxyphenyl acetic acid ( dopac ) and dopamine ( da ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
154,
168
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
178,
189
]
} |
based on the clinical , experimental and biomechanical studies the authors suggest intraarticular treatment of rheumatoid arthritis ( ra ) and deforming osteoarthrosis ( doa ) by means of artificial synovial fluid ( asf ) developed with the use of polymers and biopolymers . | NA | {
"id": "C0032521",
"name": "polymers",
"pos": [
248,
256
]
} | {
"id": "C0005554",
"name": "biopolymers",
"pos": [
261,
272
]
} |
it was discovered that an attack of stable ap occurs approximately at the same level of the rs tension in all the functional classes of ap . | NA | {
"id": "C0340288",
"name": "stable ap",
"pos": [
36,
45
]
} | {
"id": "C0002962",
"name": "ap",
"pos": [
136,
138
]
} |
the most pronounced decrease in the cortisol level and destabilization of pituitary-adrenal function were found in the visceral ra pattern , particularly in subjects treated with corticosteroids and in those with hormone-dependent ra . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
179,
194
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
213,
220
]
} |
experiments performed with low-molecular-weight heparin , n-desulfated heparin , dextran sulfate , chondroitin sulfate and dextran indicated that the inhibitory effects of heparin on neutrophil chemotaxis are not related to its anticoagulant activity , but probably depend on the degree of sulfation of the heparin molec... | NA | {
"id": "C0019139",
"name": "low-molecular-weight heparin",
"pos": [
27,
55
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
307,
314
]
} |
the rise in coagulation factors that occurs could be due to increased synthesis or increased activation by thrombin , or to both . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
12,
31
]
} | {
"id": "C0040018",
"name": "thrombin",
"pos": [
107,
115
]
} |
we have found that platelet aggregation and the release reaction are enhanced by combinations of the hormones adrenaline , noradrenaline , vasopressin and 5 hydroxytryptamine acting synergistically at levels obtained in circulating blood for three of these hormones . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
110,
120
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
123,
136
]
} |
the clot formation caused by reptilase ( release of fibrinopeptide a ) was accompanied by increase in the release of b beta 1-42 from des a fibrin ( fibrin without fibrinopeptide a ) . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
52,
58
]
} | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
164,
180
]
} |
trisaccharides , glcnac-glcua-aman and glcnac-idua-aman , were released from the nonreducing end of hs-oligosaccharides by deaminative cleavage . | NA | {
"id": "C0041102",
"name": "trisaccharides",
"pos": [
0,
14
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
103,
119
]
} |
this suggests that there might be excessive excretion of a mineralocorticoid other than aldosterone or that there might be abnormal regulation of na and k metabolism by the renin-angiotensin-aldosterone system . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
44,
53
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
155,
165
]
} |
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