text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
on the basis of the clinical , macroscopic and histological findings , this lesion was considered to be an hamartoma , rather than a true tumour , and was therefore termed a congenital vascular naevus . | NA | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
107,
116
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
138,
144
]
} |
specific immunoprecipitation of radiolabeled membrane proteins followed by electrophoretic separation and autoradiography were used to identify the protein molecules carrying these fetal antigens . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
45,
62
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
148,
155
]
} |
both major hemoglobins of cat blood , hba ( alpha 2 beta a2 ) and hbb ( alpha 2 beta b2 ) , were synthesized in an mrna-dependent rabbit reticulocyte system using poly ( a ) -rna from cat reticulocyte polysomes as the source of the message . | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
11,
22
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
38,
41
]
} |
analytical polyacrylamide gel electrophoresis of total rna showed that no obvious relation existed between rrna gene number and rrna content . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
55,
58
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
128,
132
]
} |
this is consistent with low rates of association and dissociation for the toxin with enzyme and the enzyme-toxin complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
85,
91
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
100,
106
]
} |
this increase in insp2 could have been due to increased degradation of phosphatidylinositol 4-phosphate or inhibition of breakdown of insp2 to insp with a lesser inhibition of breakdown of insp3 to insp2 . | NA | {
"id": "C0021554",
"name": "insp",
"pos": [
17,
21
]
} | {
"id": "C0021549",
"name": "insp3",
"pos": [
189,
194
]
} |
whether the increase in insp was due to increased degradation of phosphatidylinositol or a greater rate of breakdown of insp2 to insp than insp to inositol can not be determined in these experiments . | NA | {
"id": "C0021554",
"name": "insp",
"pos": [
24,
28
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
147,
155
]
} |
the 130 kda phosphoprotein resembles a corresponding protein in the erythrocyte membrane , whereas the 100 kda protein resembles that of the ca2+-transport atpase in sarcoplasmic reticulum from skeletal muscle . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
12,
26
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
111,
118
]
} |
the presence of the calmodulin-stimulated atpase in mixed membranes from smooth muscle is confirmed by its binding of calmodulin and antibodies against erythrocyte ca2+-transport atpase , whereas such binding does not occur with proteins present in the presumed endoplasmic reticulum from smooth muscle . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
42,
48
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
164,
167
]
} |
stimulation of mucin release by isoproterenol ( 10 microm ) , noradrenaline ( 10 microm ) or adrenaline ( 10 microm ) was inhibited by propranolol ( 30 microm ) but not by phentolamine ( 30 microm ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
62,
75
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
93,
103
]
} |
for the ptdgro series , fatty acid composition was important , with the shorter chain or unsaturated fatty acid-containing ptdgro species being the best activators . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
24,
34
]
} | {
"id": "C0015690",
"name": "unsaturated",
"pos": [
89,
100
]
} |
the high carbohydrate content ( 75 % ) , blood-group-a activity and typical monosaccharide composition ( l-fucose , d-galactose , n-acetyl-d-glucosamine and n-acetyl-d-galactosamine in the proportions 0.26:1.00:1.85:1.30 ) indicate that the isolated hmr-mgp is a mucinous substance . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
9,
21
]
} | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
76,
90
]
} |
after incubating pieces of human gastric mucous membrane with radioactive galactose , labeled metabolites of glycolysis ( fdp , pep , pyruvate ) : hexose and hexosamine intermediates in glycoconjugate biosynthesis ( gal-1p , udp-gal , acetylated hexosamines , and their phosphate esters ) , amino acids ( glycine , alani... | NA | {
"id": "C0016945",
"name": "galactose",
"pos": [
74,
83
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
147,
153
]
} |
after incubating pieces of human gastric mucous membrane with radioactive galactose , labeled metabolites of glycolysis ( fdp , pep , pyruvate ) : hexose and hexosamine intermediates in glycoconjugate biosynthesis ( gal-1p , udp-gal , acetylated hexosamines , and their phosphate esters ) , amino acids ( glycine , alani... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
291,
302
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
305,
312
]
} |
after incubating pieces of human gastric mucous membrane with radioactive galactose , labeled metabolites of glycolysis ( fdp , pep , pyruvate ) : hexose and hexosamine intermediates in glycoconjugate biosynthesis ( gal-1p , udp-gal , acetylated hexosamines , and their phosphate esters ) , amino acids ( glycine , alani... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
291,
302
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
315,
322
]
} |
peptide methyl ketones were found to be efficient competitive inhibitors of thermitase while the chloromethyl ketone derivatives in general inhibit the enzyme irreversibly . | NA | {
"id": "C0001002",
"name": "methyl ketones",
"pos": [
8,
22
]
} | {
"id": "C0022634",
"name": "ketone",
"pos": [
110,
116
]
} |
thus , epidermal growth factor and the compounds in fetal calf serum have the same effect as earlier described for insulin and proinsulin [ 1-3 ] . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
115,
122
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
127,
137
]
} |
when platelets are deprived from gsh by oxidation to gssg , the release of endogenous aa from phospholipids in activated platelets is inhibited . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
33,
36
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
53,
57
]
} |
characterization of a chemically tritiated large molecular weight glucagon immunoreactive protein species by lectin-affinity column chromatography and reaction with anti-glucagon antibodies . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
90,
97
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
109,
115
]
} |
inasmuch as phenolic steroids coupled to proteins have been used for the induction of estrogenic-specific antibodies , the irreversible binding observed between estrone and albumin by photosensitization might be an explanation for ( photo ) allergic disorders associated with estrogens . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
41,
49
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
173,
180
]
} |
since cyanocobalamin seems to play hardly any significant biochemical role in healthy humans , several physicians prefer to administer hydroxocobalamin to vitamin b12 deficient patients . | NA | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
6,
20
]
} | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
135,
151
]
} |
the influence of the phorbol ester , 12-o-tetradecanoylphorbol-13 acetate ( tpa ) on the contractility of rat and rabbit aorta was assessed . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
21,
34
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13 acetate",
"pos": [
37,
73
]
} |
epirubicin inhibits endogenous respiration by 18 % versus control while doxorubicin and mitoxantrone reduce oxygen uptake by 34 and 46 % , respectively . | NA | {
"id": "C0014582",
"name": "epirubicin",
"pos": [
0,
10
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
72,
83
]
} |
lipoprotein-deficient plasma and human serum albumin , but not very low density lipoproteins and low density lipoproteins , also removed excess cholesterol from the red blood cells . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
0,
11
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
63,
79
]
} |
to test the hypothesis that thermogenic mw exposure results in the release of endotoxin across the intestinal epithelium which subsequently activates pm , hamsters were injected with lipopolysaccharide ( lps ) and their viricidal activity was studied . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
78,
87
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
183,
201
]
} |
a complex pattern of inhibition of acetylcholinesterase and butyrylcholinesterase by these compounds was caused by kinetically-manifested formation of an enzyme-inhibitor complex . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
35,
55
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
60,
81
]
} |
the compounds i and ii were more selective towards butyrylcholinesterase than towards acetylcholinesterase and carboxylesterase ( kii two orders of magnitude higher ) because of effective binding in the butyrylcholinesterase active center ( k alpha 10 ( -8 ) -- 10 ( -9 ) m ) due to hydrophobic interaction . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
86,
106
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
203,
224
]
} |
the tertiary amines , procaine and nicotinoylprocaine , cause an increase in the specific activities of two glycohydrolases , alpha-fucosidase and beta-n-acetylhexosaminidase , which are involved in membrane metabolism . | NA | {
"id": "C0017976",
"name": "glycohydrolases",
"pos": [
108,
123
]
} | {
"id": "C0016787",
"name": "alpha-fucosidase",
"pos": [
126,
142
]
} |
binding of hoe 498 diacid to ace proceeds by a two-step mechanism e+i in equilibrium ei in equilibrium ei* in which the inhibitor rapidly binds to enzyme to form an initial enzyme-inhibitor complex which then undergoes a slow isomerization . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
147,
153
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
173,
179
]
} |
the presence of circulating immune complexes , serum immunoglobulins , c3 ( the third component of complement ) , antibodies to alpha-lactalbumin , beta-lactoglobulin and bovine serum albumin was studied in 39 patients subjected to coronary arteriography . | NA | {
"id": "C0003313",
"name": "circulating immune complexes",
"pos": [
16,
44
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
114,
124
]
} |
examples of rat lymph and plasma apolipoproteins are shown , and apparent heterogeneity of certain apoprotein subgroups is described . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
33,
48
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
99,
109
]
} |
hepatocellular clearance function of bacterial lipopolysaccharides and free lipid a in mice with endotoxic shock . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
47,
66
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
76,
83
]
} |
hepatic uptake of bacterial lipopolysaccharides ( lps ) in defined salt forms and free lipid a was studied in c3h mice . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
28,
47
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
87,
94
]
} |
extracts of 14c-labeled and unlabeled lps from salmonella abortus equi and lipid a from salmonella minnesota r 595 ( re ) were administered intravenously in doses sufficient to induce endotoxic shock . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
38,
41
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
75,
82
]
} |
by use of immunofluorescence , lps s abortus equi was localized in sinusoidal cells 5 to 10 minutes after administration , and lps s minnesota r 595 and lipid a were found in both nonparenchymal and parenchymal liver cells . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
31,
34
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
153,
160
]
} |
after application of lps or lipid a , the third complement component ( c3 ) was detectable in sinusoidal cells . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
21,
24
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
28,
35
]
} |
in decomplemented mice the hepatic deposits of lps and lipid a were unaffected , without demonstration of c3 . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
47,
50
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
55,
62
]
} |
the data indicate that lps and lipid a interact in vivo with kupffer cells and hepatocytes . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
23,
26
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
31,
38
]
} |
studies have demonstrated the synthesis and release of various prostanoids during global injuries such as circulatory shock , burn injury , myocardial infarction , and severe trauma . | NA | {
"id": "C0006434",
"name": "burn",
"pos": [
126,
130
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
175,
181
]
} |
most importantly , a close correlation has been found between the presence of c5a-desarg in plasma and the subsequent onset of shock lung in patients after trauma , burns , and sepsis . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
156,
162
]
} | {
"id": "C0006434",
"name": "burns",
"pos": [
165,
170
]
} |
recent data indicate that the neurohypophyseal hormone oxytocin ( oxt ) and z-prolyl-d-leucine ( z-pro-d-leu ) , a synthetic dipeptide derived from the c-terminal part of oxt , attenuate the development of tolerance to and dependence on morphine in the mouse . | NA | {
"id": "C0032017",
"name": "neurohypophyseal hormone",
"pos": [
30,
54
]
} | {
"id": "C0030095",
"name": "oxt",
"pos": [
171,
174
]
} |
minimal inhibitory concentrations ( mics ) of six beta-lactam antibiotics ( ampicillin , cephaloridine , cephalexine , cefazoline , cefuroxime , cefotaxime ) were determined on 90 non beta-lactamase producing and 94 beta-lactamase producing strains by a miniaturized dilution method . beta-lactamase production transfer ... | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
132,
142
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
145,
155
]
} |
in the present study we have investigated whether or not hofbauer cells could subserve the function of accessory cells for colony formation by phytohemagglutinin stimulated allogeneic t cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
66,
71
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
173,
183
]
} |
dynamic ct was performed on 20 patients with brain tumor ( three meningiomas , one pineal tumor , three metastatic brain tumors , thirteen gliomas ) . | NA | {
"id": "C0006118",
"name": "brain tumor",
"pos": [
45,
56
]
} | {
"id": "C0031941",
"name": "pineal tumor",
"pos": [
83,
95
]
} |
these results suggest that administrated trh analog or trh may inhibit an occurrence of subsequent seizures and prevent the epileptic status . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
99,
107
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
124,
133
]
} |
more than 3 g/day of thiamylal or more than 1.5 g/day of pentobarbital were administered for barbiturate therapy . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
57,
70
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
93,
104
]
} |
mycoplasma hominis was isolated most often from the women who had threatened abortions but otherwise the prevalence of the other various micro-organisms was similar in women who had spontaneous abortions , threatened abortions , and in those who had pregnancies uncomplicated by vaginal bleeding . | NA | {
"id": "C0000786",
"name": "spontaneous abortions",
"pos": [
182,
203
]
} | {
"id": "C0000821",
"name": "threatened abortions",
"pos": [
206,
226
]
} |
maternal serum levels of human placental lactogen ( hpl ) , schwangerschaftsprotein 1 ( sp1 ) and pregnancy-associated plasma protein a ( papp-a ) were measured serially throughout pregnancy in 753 women who had a normal pregnancy when recruited during the second trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
98,
107
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
257,
273
]
} |
biliverdin reductase ( molecular form 1 ) from rat liver efficiently reduced the isomer mixtures of biliverdins i , xi , xiv and harderobiliverdins to the bilirubins in the presence of nadph . | NA | {
"id": "C0005446",
"name": "biliverdins",
"pos": [
100,
111
]
} | {
"id": "C0005437",
"name": "bilirubins",
"pos": [
155,
165
]
} |
the localization of the probe in lipoproteins of high , low and very low density and in lipid spheres is studied . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
33,
45
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
88,
93
]
} |
all the probe molecules are localized on the surface of lipid spheres and lipoproteins and the b-ring of the molecule is immersed on 1.3 +/- 0.2 nm relative to polar groups . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
56,
61
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
74,
86
]
} |
the enzyme sensitivity to the action of isoproterenol ( 0.1 mm ) and gtp ( 0.1 mm ) decreases by 50 % for 15 min , that to guanylyl imidodiphosphate , a non-hydrolyseable analog of atp , by 20-25 % for 40 min . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
69,
72
]
} | {
"id": "C0018366",
"name": "guanylyl imidodiphosphate",
"pos": [
123,
148
]
} |
the results of experiments with the enzyme samples from skin fibroblasts of healthy individuals and of patients with gm1-gangliosidosis ( gm1-beta-d-galactosidase deficiency ) suggest that gal-a-sphingenin is a specific substrate for gc . | NA | {
"id": "C0016955",
"name": "galactosidase",
"pos": [
149,
162
]
} | {
"id": "C0016957",
"name": "gc",
"pos": [
234,
236
]
} |
the enzyme sensitivity to isoproterenol ( 0.2 mm ) and gtp ( 1.0 mm ) decreases by 50 % after 20 min incubation , while that to guanylyl imidodiphosphate ( 0.1 mm ) , a non-hydrolyzeable analogue of gtp , is lowered by 20-25 % after 40 min . | NA | {
"id": "C0018366",
"name": "guanylyl imidodiphosphate",
"pos": [
128,
153
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
199,
202
]
} |
the concentrations of circulating ca ranged from normal values to a more than threefold increase in na and da , whereas adrenaline ( a ) concentrations were nearly unchanged . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
100,
102
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
120,
130
]
} |
furthermore , a placebo-controlled double-blind trial of lithium carbonate in this patient found lithium ineffective in preventing the attacks of paralysis , in contrast to another recent study which found lithium effective in hypermagnesemic periodic paralysis . | NA | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
57,
74
]
} | {
"id": "C0023870",
"name": "lithium",
"pos": [
206,
213
]
} |
endogenous androgens ( androstenedione , testosterone , 5 alpha-dihydrotestosterone and 5 alpha-androstane-3 alpha,17 beta-diol ) , and some of their c21 precursors ( pregnenolone , progesterone and 17-hydroxyprogesterone ) were measured in rat testes between day 18.5 of pregnancy and day 64 postpartum , and correlated... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
182,
194
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
199,
221
]
} |
so could be explained the resistance towards proteases and the weak antigenicity of numerous glycoproteins as well as the peculiar behaviour and resistance of metastatic cancerous cells since it has been recently demonstrated that membrane glycoproteins and fibronectin of this kind of cells are significantly enriched i... | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
93,
106
]
} | {
"id": "C0025248",
"name": "membrane glycoproteins",
"pos": [
231,
253
]
} |
soluble lectins of chicken , rat , frog , and the cellular slime mold , dictyostelium discoideum , were purified and specific antibodies raised against these proteins were used to immunohistochemically localize the lectins in and around the tissues in which they were synthesized . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
158,
166
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
215,
222
]
} |
we have demonstrated that at least three different types of lectin-like proteins mediate the mannose-sensitive adherence of gram negative bacteria to epithelial cells . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
60,
66
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
72,
80
]
} |
it is therefore believed that the mannose-sensitive adherence of these bacteria is mediated also by lectin-like proteins associated directly with the outer membrane . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
100,
106
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
112,
120
]
} |
new patterns of cocaine abuse , such as the inhalation of vaporized cocaine base , the intravenous injection of cocaine hydrochloride and the smoking of coca paste , produce a brief elation that quickly gives way either to a return to the baseline mood or to displeasure , resulting in a strong desire to return to the m... | NA | {
"id": "C0009170",
"name": "cocaine",
"pos": [
16,
23
]
} | {
"id": "C0282108",
"name": "cocaine",
"pos": [
112,
119
]
} |
intracerebroventricular injections of cado , l-pia and 5'-n-ethylcarboxamide adenosine ( neca ) , but not of 2'-deoxyadenosine , antagonized morphine antinociception . | NA | {
"id": "C0031484",
"name": "l-pia",
"pos": [
45,
50
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
117,
126
]
} |
effects of adenosine , adenosine triphosphate and structural analogues on glucagon secretion from the perfused pancreas of rat in vitro . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
11,
20
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
23,
45
]
} |
the effects of adenosine , adenosine triphosphate ( atp ) and structural analogues have been studied on glucagon secretion from the isolated perfused pancreas of the rat in the presence of glucose ( 2.8 mm ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
15,
24
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
27,
49
]
} |
2-chloroadenosine , an analogue more resistant to metabolism or uptake systems than adenosine , was more effective . | NA | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
0,
17
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
84,
93
]
} |
among the three structural analogues of atp or adp studied , beta , gamma-methylene atp which can be hydrolyzed into amp and adenosine had an effect similar to adenosine or atp at the same concentrations ( 1.65 and 16.5 microm ) ; | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
125,
134
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
173,
176
]
} |
theophylline ( 50 microm ) a specific blocker of the adenosine receptor , suppressed the glucagon peak induced by adenosine , 2-chloroadenosine , atp and beta , gamma-methylene atp ( 1.65 microm ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
53,
62
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
126,
143
]
} |
theophylline ( 50 microm ) a specific blocker of the adenosine receptor , suppressed the glucagon peak induced by adenosine , 2-chloroadenosine , atp and beta , gamma-methylene atp ( 1.65 microm ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
53,
62
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
177,
180
]
} |
sixty three patients presumed to have genital gonorrhoea who gave histories of extragenital sexual practices were randomly treated with amoxycillin 3 g or bacampicillin 4.8 g ( equivalent to 3.5 g ampicillin ) with probenecid 1 g to compare the efficacy of the drugs in treating gonorrhoea at all sites . | NA | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
136,
147
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
197,
207
]
} |
sixty three patients presumed to have genital gonorrhoea who gave histories of extragenital sexual practices were randomly treated with amoxycillin 3 g or bacampicillin 4.8 g ( equivalent to 3.5 g ampicillin ) with probenecid 1 g to compare the efficacy of the drugs in treating gonorrhoea at all sites . | NA | {
"id": "C0052865",
"name": "g",
"pos": [
38,
39
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
197,
207
]
} |
biochemical studies centering on the use of reverse-phase high-performance liquid chromatography ( hplc ) and radioimmunoassays ( ria ) demonstrate the presence in the guinea pig organ of corti of at least 3 enkephalin-related peptides , two of which are identified as met- and leu-enkephalin , respectively . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
208,
218
]
} | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
278,
292
]
} |
all enkephalins identified by the combined hplc-ria procedure had an apparent molecular weight similar to that of met- and leu-enkephalin peptide standards . | NA | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
4,
15
]
} | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
123,
137
]
} |
immunocytochemistry , performed with the best-characterized met-enkephalin antiserum used in the rias , localized the enkephalin-like immunoreactivity to lateral efferent fibers and terminals under inner hair cells of the organ of corti . | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
60,
74
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
118,
128
]
} |
other antisera raised against met-enkephalin , not used for ria , visualized enkephalin-like immunoreactivity in medial efferent fibers under outer hair cells as well . | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
30,
44
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
77,
87
]
} |
it was observed as a common characteristic in all 3 strains of mice that generalization gradients among sugars and saccharin na appeared in the order sucrose -- saccharin na -- fructose -- glucose -- maltose , in which the closer stimuli generalized more strongly to each other . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
104,
110
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
150,
157
]
} |
kinetic studies of highly purified rat renin and rat tonin on completely purified angiotensinogen and angiotensin-tetradecapeptide synthetic renin substrate were performed . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
82,
93
]
} | {
"id": "C0003017",
"name": "renin",
"pos": [
141,
146
]
} |
phenylalanine-sensitive isolates may have a defect in aromatic amino acid synthesis , not involving auxotrophy , but manifested through regulation of the pathways . | NA | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
0,
13
]
} | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
54,
73
]
} |
while there is insufficient evidence to prohibit alcohol completely ( even chianti wine ) true moderation must apply . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
49,
56
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
83,
87
]
} |
from an eeg laboratory with many referrals with epilepsy , a 48 % incidence of clinical sz in pts with sss was significantly higher than the 15 % in pts with normal eegs , but lower than the 78 % in pts with sss and other paroxysms ; | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
48,
56
]
} | {
"id": "C0036572",
"name": "sz",
"pos": [
88,
90
]
} |
serum mk422 ( enalaprilic acid , the bioactive form of enalapril ) and serum angiotensin converting enzyme ( ace ) inhibition had a similar time course with good correlation between drug levels and ace inhibition ( p less than 0.001 , r = 0.98 , n = 16 ) and between ace inhibition and the hypotensive effect ( p less th... | NA | {
"id": "C0014027",
"name": "enalaprilic acid",
"pos": [
14,
30
]
} | {
"id": "C0014025",
"name": "enalapril",
"pos": [
55,
64
]
} |
examination of amino acid residues involved in the enzymatic hydrolysis by human renin of the unique leu10-val11 bond of human angiotensinogen revealed features peculiar to this highly specialized aspartyl protease . | NA | {
"id": "C0035094",
"name": "renin",
"pos": [
81,
86
]
} | {
"id": "C0078989",
"name": "aspartyl protease",
"pos": [
197,
214
]
} |
all the above effects of angiotensin i and angiotensin ii were blocked by the receptor antagonist saralasin , but only those of angiotensin i were blocked by the converting enzyme inhibitor enalaprilat ( mk-422 ) . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
43,
57
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
98,
107
]
} |
although under these conditions the apparent rate of cellular rna synthesis was unchanged , inhibiting residual cycloheximide-resistant nuclear protein synthesis with puromycin proportionately reduced rna synthesis . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
62,
65
]
} | {
"id": "C0035700",
"name": "nuclear",
"pos": [
136,
143
]
} |
since methionine is commonly used as a label for newly synthesized protein , this phenomenon may be important not only in the investigation of globin synthesis , but also in the study of the synthesis of other proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
67,
74
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
191,
200
]
} |
electrophoretic profiles of the adult peccary showed at least six distinct protein bands corresponding to the fractions : albumin , alpha-1 , alpha-2 , beta-1 , beta-2 , and gamma globulin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
75,
82
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
122,
129
]
} |
the relationship between free cholesterol and total lipids is 12-14 % and that between esterified cholesterol and total lipids is 4-5 % , both of the two being maintained during the animal development . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
30,
41
]
} | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
87,
109
]
} |
exposure of migrating cells to the plant lectin , concanavalin a ( con a ) , lowered cyclic amp ( camp ) levels and depressed migration . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
35,
47
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
50,
64
]
} |
a procedure is described for simultaneous estimation of tryptophan ( tp ) , 5-hydroxytryptophan ( 5-ohtp ) , 5-hydroxytryptamine ( 5-ht ) , 5-hydroxyindoleacetic acid ( 5-hiaa ) , n-acetyl 5-hydroxytryptamine ( na5-ht ) and n-acetyldopamine ( nada ) using high performance liquid chromatography with coulometric electroc... | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
56,
66
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
76,
95
]
} |
while a dose of 5-6 micrograms kg-1 body wt of norepinephrine increased the rate and amplitude of branchial and cardiac electrical recordings , the same dose of epinephrine produced a comparable effect only on the heart recordings . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
47,
61
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
161,
172
]
} |
canine serum albumin was found to bind six or more cu2+ and ni2+ ions with affinities that are lower than for human or bovine serum albumin . | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
7,
20
]
} | {
"id": "C0036774",
"name": "bovine serum",
"pos": [
119,
131
]
} |
similar responses to adrenaline and noradrenaline were antagonized by propranolol and phentolamine in partially different manners . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
21,
31
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
36,
49
]
} |
intracellular recordings were made and the effects of local application of the neuropeptide fmrfamide were tested on selected neurones . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
79,
91
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
92,
101
]
} |
chlorpropamide and tolazamide are sulfonylurea oral hypoglycemic agents , neither of which has previously been implicated in cutaneous lichenoid reactions . | NA | {
"id": "C0008287",
"name": "chlorpropamide",
"pos": [
0,
14
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
34,
46
]
} |
chlorpropamide and tolazamide are sulfonylurea oral hypoglycemic agents , neither of which has previously been implicated in cutaneous lichenoid reactions . | NA | {
"id": "C0040372",
"name": "tolazamide",
"pos": [
19,
29
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
34,
46
]
} |
physical data suggest that the respiratory and gastric mucins conform to the model for the polymeric structure proposed previously for cervical mucins . | NA | {
"id": "C0017135",
"name": "gastric mucins",
"pos": [
47,
61
]
} | {
"id": "C0026682",
"name": "mucins",
"pos": [
144,
150
]
} |
l-fucose and n-acetylneuraminic ( sialic ) acid occupy terminal positions on the oligosaccharide side-chains of human cervical mucin but the addition of both these monosaccharides to the same carbohydrate acceptor residue is kinetically unfavourable . | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
164,
179
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
192,
204
]
} |
it is suggested that the observed beneficial effect is due to the specific inhibition of xanthine oxidase associated with ap therapy leading to reduced generation of superoxide radicals and decreased urinary loss of purine . | NA | {
"id": "C0002144",
"name": "ap",
"pos": [
122,
124
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
216,
222
]
} |
trauma and the internal trabecular structure of bone are additional determinants of risk of fracture . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
0,
6
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
92,
100
]
} |
after an initial stabilization ( min . 15 days ) with oral haloperidol , patients received haloperidol decanoate im for at least 24 weeks ( or a minimum of 9 injections ) . | NA | {
"id": "C0018546",
"name": "haloperidol",
"pos": [
59,
70
]
} | {
"id": "C0062103",
"name": "haloperidol decanoate",
"pos": [
91,
112
]
} |
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