text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the association of the covalently labeled polypeptides with the membrane was investigated by treatment of labeled synaptosomes with various agents known to remove proteins only indirectly attached to the lipid bilayer via a membrane-bound protein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
163,
171
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
224,
232
]
} |
the method involves ( 1 ) saturating a small column of phenyl-sepharose ( 1-2 ml ) with one of the alkyl detergents at a ph of 8 or 9 and an ionic strength of 0.01 , ( 2 ) applying a detergent-solubilized membrane protein sample containing as much as 20 mg/ml of triton x-100 , triton n-101 , or nonidet p-40 , and ( 3 )... | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
205,
221
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
333,
340
]
} |
escherichia coli single-stranded dna binding protein is mobile on dna : 1h nmr study of its interaction with oligo- and polynucleotides . | NA | {
"id": "C0028953",
"name": "oligo",
"pos": [
109,
114
]
} | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
120,
135
]
} |
at low protein : dna ratios , both h1 and h5 bound more z-dna than b-dna , and binding of z-dna was less sensitive to interference by an increase in ionic strength ( to 600 mm nacl ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
17,
20
]
} | {
"id": "C0043442",
"name": "z-dna",
"pos": [
90,
95
]
} |
when fractions containing eif-4b , eif-4f , or eif-4a were added to these lysates in the presence of eif-2 , all three stimulated translation . | NA | {
"id": "C0058989",
"name": "eif-4f",
"pos": [
35,
41
]
} | {
"id": "C0058984",
"name": "eif-4a",
"pos": [
47,
53
]
} |
the interactions of factor v and factor va light chain with phospholipid vesicles were compared . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
20,
28
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
33,
42
]
} |
the results showed that the factor va light chain bound with the same parameters as factor v when the proteins were present at similar densities on the membrane . | NA | {
"id": "C0015501",
"name": "factor va",
"pos": [
28,
37
]
} | {
"id": "C0015498",
"name": "factor v",
"pos": [
84,
92
]
} |
the protein-vesicle collisional efficiency was 30-50 % for both factor v and factor va light chain . | NA | {
"id": "C0015498",
"name": "factor v",
"pos": [
64,
72
]
} | {
"id": "C0015501",
"name": "factor va",
"pos": [
77,
86
]
} |
factor va generated by thrombin digestion of factor v did not result in a major loss of membrane-bound protein mass unless ethylenenediaminetetraacetic acid was present ; | NA | {
"id": "C0015501",
"name": "factor va",
"pos": [
0,
9
]
} | {
"id": "C0015498",
"name": "factor v",
"pos": [
45,
53
]
} |
13c nmr spectroscopy of 90 % -enriched [ [ 3-13c ] ala1 ] phospholipases a2 shows the pk values of the alpha-nh3+ groups of porcine enzyme , porcine isoenzyme , bovine enzyme , and equine enzyme to be 8.4 , 8.8 , 8.9 , and 8.8 , respectively . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
149,
158
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
188,
194
]
} |
no such effects were observed for the porcine isoenzyme and bovine enzyme , which lack an acidic side chain in position 71 . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
46,
55
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
67,
73
]
} |
evidence for the actin-like nature of the mitochondrial protein could be obtained from the fact that the protein inhibited the activity of pancreatic dnaase i which , similar to the smooth muscle protein , was less conspicuous than that of its muscle counterpart . | NA | {
"id": "C0949610",
"name": "mitochondrial protein",
"pos": [
42,
63
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
196,
203
]
} |
the kd value [ ( 0.40 +/- 0.09 ) x 10 ( -7 ) m ] , the absorption capacity of glycogen towards the enzyme [ am = ( 1.89 +/- 0.4 ) x 10 ( -6 ) mol ] and the number of enzyme-binding sites per polysaccharide molecule ( n = 10 ) were determined , using rabbit liver glycogen ( mr = 5.28 x 10 ( 6 ) ) . | NA | {
"id": "C0017911",
"name": "glycogen",
"pos": [
78,
86
]
} | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
257,
271
]
} |
in the presence of glutamic acid , the glutamine and asparagine contents in the heart-perfusate system markedly increased ; | NA | {
"id": "C0061472",
"name": "glutamic",
"pos": [
19,
27
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
39,
48
]
} |
twenty-four male and twenty-four female undergraduates took part in an experiment to investigate the effects of gender and familial handedness on hemispheric activation during numeric and visuospatial thinking . | NA | {
"id": "C0086582",
"name": "male",
"pos": [
12,
16
]
} | {
"id": "C0079399",
"name": "gender",
"pos": [
112,
118
]
} |
generalized poisson-boltzmann calculation of the distribution of electrolyte ions around the b- and z-conformers of dna . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
65,
76
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
77,
81
]
} |
golden hamsters were submitted , three times a week during 4 weeks , to i.p . administration of an antracenedione , mitoxantrone ( mtx ) , and 12 different anthracyclines , adriamycin ( adm ) , detorubicin ( dtr ) , daunorubicin ( dnr ) , 4'-epi-adriamycin ( e-adm ) , rubidazone ( rbz ) , aclacinomycin ( acm ) , n-trif... | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
216,
228
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
445,
457
]
} |
according to the degree of their cardiotoxicity , skin toxicity , and general toxicity or mortality , all drugs studied are classified into 3 groups : 1st group , adm , dnr , 1-dnr and rbz , causing very severe cardiac alterations and alopecia ( grade 2-3 ) , and very high mortality , 2nd group , e-adm , dtr , cam rbc ... | NA | {
"id": "C0011015",
"name": "dnr",
"pos": [
169,
172
]
} | {
"id": "C0007308",
"name": "cam",
"pos": [
312,
315
]
} |
fetal calf serum and a serum substitute , ultroser g , were compared for their effects on the growth curves , clonal growth and cell cycle progression of rabbit chondrocytes in primary culture and during at least three cell passages and included a screen for the maintenance of cartilage-like differentiation i.e . the p... | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
161,
173
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
219,
223
]
} |
this substance also antagonized the inhibition of spontaneous bladder contractions produced by submaximal i.c.v . doses of the highly selective mu opioid agonist [ d-ala2-mephe4 , gly- ( ol ) 5 ] enkephalin ( dago ) and the delta opioid agonist [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ) . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
196,
206
]
} | {
"id": "C0525773",
"name": "dago",
"pos": [
209,
213
]
} |
this substance also antagonized the inhibition of spontaneous bladder contractions produced by submaximal i.c.v . doses of the highly selective mu opioid agonist [ d-ala2-mephe4 , gly- ( ol ) 5 ] enkephalin ( dago ) and the delta opioid agonist [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ) . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
196,
206
]
} | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
278,
283
]
} |
the behavioral interaction of intraperitoneal ( i.p . ) injections of diazepam with intracerebroventricular ( i.c.v.t . ) injections of adenosine or 5'-n-ethylcarboxamidoadenosine ( neca ) was examined on spontaneous locomotor activity . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
136,
145
]
} | {
"id": "C0050789",
"name": "5",
"pos": [
149,
150
]
} |
in contrast , i.p . injections of diazepam did not potentiate the locomotor depressant effects of i.c.v.t . injections of neca , an uptake resistant analog of adenosine . | NA | {
"id": "C0050789",
"name": "neca",
"pos": [
122,
126
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
159,
168
]
} |
an anterograde-retrograde transneuronal transport of conjugates of wheat germ agglutinin with horseradish peroxidase ( wga-hrp ) : labeling of neurons in the reticular nucleus of the thalamus with wga-hrp injected into the posterior column nuclei in the cat . | NA | {
"id": "C0078473",
"name": "conjugates",
"pos": [
53,
63
]
} | {
"id": "C0019941",
"name": "wga-hrp",
"pos": [
197,
204
]
} |
we studied ventilation and ventilatory pattern in adult unanesthetized dogs after intracisternal administration of morphiceptin analogue ( ma ) ( tyr-pro-nmephe-d-pro-nh2 ) and morphine sulfate ( ms ) which are mu-receptor opioid agonists and after d-ala-d-leu-enkephalin ( dadle ) , a preferential delta-receptor opioid... | NA | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
257,
271
]
} | {
"id": "C0079286",
"name": "dadle",
"pos": [
274,
279
]
} |
these data suggest that in the unanesthetized dog : ( 1 ) the effect of intracisternal opioids on ventilation and ventilatory pattern is not uniform and ( 2 ) the opioid mu-receptor subsystem may involve different neuronal pathways from those of the opioid delta-receptor subsystem to modulate breathing . | NA | {
"id": "C0034801",
"name": "opioid",
"pos": [
87,
93
]
} | {
"id": "C0140057",
"name": "opioid delta-receptor",
"pos": [
250,
271
]
} |
saralasin alone generally decreases spontaneous activity and the results indicate that this effect may be due to an inhibition of endogenous brain angiotensin ii . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
0,
9
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
147,
161
]
} |
the data provide evidence that pcp at the doses tested alters dopaminergic neurotransmission in a manner different from that of amphetamine and the non-amphetamine central nervous system stimulants by decreasing da release from dopaminergic nerve terminals . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
4,
6
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
228,
240
]
} |
spermine and spermidine at physiological concentrations aggregated liposomes composed of pure phosphatidylserine ( ps ) or phosphatidate ( pa ) and mixtures of pa with phosphatidylcholine ( pc ) but did not induce any fusion . | NA | {
"id": "C0037874",
"name": "spermine",
"pos": [
0,
8
]
} | {
"id": "C0037871",
"name": "physiological",
"pos": [
27,
40
]
} |
however , liposomes composed of mixtures of acidic phospholipids , cholesterol , and a high mole fraction of phosphatidylethanolamine could be induced to fuse by spermine and spermidine in the absence of divalent cations . | NA | {
"id": "C0037874",
"name": "fuse",
"pos": [
154,
158
]
} | {
"id": "C0037871",
"name": "absence",
"pos": [
193,
200
]
} |
among these isoforms a specific family of beta proteins ( beta ' tubulin ) and the more acidic alpha proteins were present . | NA | {
"id": "C0597298",
"name": "isoforms",
"pos": [
12,
20
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
101,
109
]
} |
the enzyme changes the linking number of dna circles in steps of two and reversibly knots or catenates dna rings . | NA | {
"id": "C0012925",
"name": "dna circles",
"pos": [
41,
52
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
103,
106
]
} |
in general , there was a good correlation between the sequential and temporal puffing activity induced by 20-hydroxy-ecdysone and the binding of ecdysteroid hormone to these puffs . | NA | {
"id": "C0013494",
"name": "ecdysone",
"pos": [
117,
125
]
} | {
"id": "C0058915",
"name": "ecdysteroid",
"pos": [
145,
156
]
} |
ecdysteroid was not detected at the two well-studied puffs at 23e and at 25ac , the former being an early puff , which is activated in the presence of 20-hydroxy-ecdysone , and the latter being an intermolt puff , which regresses more rapidly in the presence of hormone . | NA | {
"id": "C0058915",
"name": "ecdysteroid",
"pos": [
0,
11
]
} | {
"id": "C0013494",
"name": "ecdysone",
"pos": [
162,
170
]
} |
the production of fibronectin by newborn rat epidermal cells was shown by indirect immunofluorescence staining of cultures grown in the absence of a feeder layer using an antiserum which had been cross-adsorbed with foetal calf serum proteins to remove antibodies which recognised serum fibronectin . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
171,
180
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
253,
263
]
} |
cell cultures obtained from the germinal layer of hydatid cysts of the parasitic tapeworm echinococcus granulosus were characterized with respect to their microtubule and microfilament systems . | NA | {
"id": "C0013502",
"name": "hydatid cysts",
"pos": [
50,
63
]
} | {
"id": "C0007894",
"name": "tapeworm",
"pos": [
81,
89
]
} |
through the above mentioned microanalysis , it was found that the principal composition of the deposition both types of iuds was calcium and existed in the crystal form of calcium carbonate . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
129,
136
]
} | {
"id": "C0006681",
"name": "calcium carbonate",
"pos": [
172,
189
]
} |
`` `` this paper presents a microanalytic stochastic model of human reproduction with special features for use in examining reproduction in high mortality populations . the model builds on prior work by including ( a ) a beta distribution for fecundability , permitting variations between women and during a woman 's chi... | NA | {
"id": "C0015927",
"name": "fetal death",
"pos": [
344,
355
]
} | {
"id": "C0595939",
"name": "stillbirth",
"pos": [
361,
371
]
} |
we have raised three new monoclonal antibodies , pab1101 , pab1102 and pab1103 , to this cellular protein , derived from sv40-transformed human fibroblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
89,
97
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
144,
155
]
} |
( i ) the junctions form a sharp band in potassium iodide density gradients at 1.195 g/cm3 and the 16 k protein is the only detectable band in fractions of this bouyant density . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
2,
3
]
} | {
"id": "C0032831",
"name": "potassium iodide",
"pos": [
41,
57
]
} |
two of the monoclonal antibodies were found suitable for a sensitive and rapid double antibody solid-phase radioimmunoassay , allowing the detection of ifn-gamma at concentrations of at least 4 ng/ml ( 150 units/ml ) within 8 h . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
11,
32
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
86,
94
]
} |
a detailed analysis of the length distribution of dna in nucleosome dimers trimmed with exonuclease iii and s1 nuclease suggests that the previously described variation of internucleosomal distance in rat liver occurs , at least for a subset of the nucleosomes , by integral multiples of the helical repeat of the dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
314,
317
]
} |
here we show that a fourth much smaller single-stranded dna , termed alpha1 , is also present in denatured camv dna preparations . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
40,
59
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
112,
115
]
} |
in chick embryo fibroblasts transformed by rous sarcoma virus ( rsv ) the tyrosine phosphorylation of a cellular protein of 34,000 daltons mol . wt . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
16,
27
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
104,
112
]
} |
the 5s rrnas made during very short pulse-labellings of the mutant have , relative to the mature 121 nucleotide 5s rna of wild-type cells , an additional 7 , 11 or 13 nucleotides at their 3 ' terminus . | NA | {
"id": "C0035701",
"name": "rrnas",
"pos": [
7,
12
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
115,
118
]
} |
of 18 animals bearing r3230ac tumors , four developed palpable lymph node metastasis ( macrometastasis ) , while another five showed evidence of metastasis only upon histological examination ( micrometastasis ) . | NA | {
"id": "C0027627",
"name": "metastasis",
"pos": [
74,
84
]
} | {
"id": "C1513276",
"name": "micrometastasis",
"pos": [
193,
208
]
} |
( e ) optimal images of tumors , using either 131i- or 111in-diethylenetriaminepentaacetic acid-labeled antibodies , were obtained early after extravascular distribution of the antibody because of the rapid targeting , clearance , and excretion or metabolism of isotope ; | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
235,
244
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
248,
258
]
} |
and ( f ) changing the immunoglobulin isotype class or fragment had large effects on the half-life of the antibody but did not improve cell targeting uptake ratios or image contrast or alleviate the problem of specific catabolism . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
38,
45
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
106,
114
]
} |
resistance to the cytocidal effect of aflatoxin b1 , 2-acetylaminofluorene , n-hydroxy-2-acetylaminofluorene , methotrexate , or methyl methanesulfonate shows a progressive increase until 48 hr and then returns to the resting level of susceptibility by 2 weeks . | NA | {
"id": "C0000248",
"name": "2-acetylaminofluorene",
"pos": [
53,
74
]
} | {
"id": "C0020319",
"name": "n-hydroxy-2-acetylaminofluorene",
"pos": [
77,
108
]
} |
with urethan as an initiator , it was found that tumor promoters ( 12-o-tetradecanoylphorbol-13-acetate and phorbol-12 , 13-didecanoate ) induced a considerable response in the assay system , while nonpromoting phorbol esters ( 4-o-methyl-12-o-tetradecanoylphorbol-13-acetate and 4 alpha-phorbol-12 , 13-didecanoate ) di... | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
67,
103
]
} | {
"id": "C0031586",
"name": "phorbol",
"pos": [
288,
295
]
} |
there were 5 myeloblastic leukemias , 22 granulocytic leukemias , 17 myelomonocytic leukemias , and 8 monocytic leukemias . | NA | {
"id": "C0023479",
"name": "myeloblastic leukemias",
"pos": [
13,
35
]
} | {
"id": "C0023470",
"name": "granulocytic leukemias",
"pos": [
41,
63
]
} |
a hyperimmune rabbit antiserum to ultraviolet-irradiated dna was observed to contain two activities directed against irradiated dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
128,
131
]
} |
under a second set of conditions in which binding was measured with single-stranded dna , antibodies were bound to dna which contained only thymine-thymine dimers . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
68,
87
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
115,
118
]
} |
c1q-binding ic were reciprocally related to the presence of complement-dependent antibodies , cytotoxic for cultured allogeneic malignant melanoma cells in sera from 29 of these patients ( r = -0.491 ; p = 0.003 ) . | NA | {
"id": "C0003313",
"name": "ic",
"pos": [
12,
14
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
81,
91
]
} |
in this study , we report that retinoic acid enhances dramatically the colony-forming ability in soft-agar medium of normal rat kidney fibroblast cells nrk 536-3 ( sa6 ) exposed to sarcoma growth factor . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
67,
70
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
135,
145
]
} |
retinoic acid also stimulates colony formation in soft agar induced by the phorbol ester 12-o-tetradecanoylphorbol-13-acetate , although the phorbol ester alone is less effective in producing anchorage-independent growth than is the sarcoma growth factor . | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
89,
125
]
} | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
141,
154
]
} |
medium conditioned by 2t cells was mitogenic for quiescent balb/c3t3 cells and human diploid fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
25,
30
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
93,
104
]
} |
plasma epinephrine increased 262 % ( from 29 +/- 4 to 105 +/- 14 pg/ml , p less than 0.01 ) and plasma norepinephrine increased 64 % ( from 190 +/- 18 to 312 +/- 51 pg/ml , p less than 0.05 ) during the high-dose infusion . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
7,
18
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
103,
117
]
} |
thirty of 42 patients in whom tachycardia was not inducible after the administration of procainamide and 69 of 84 patients in whom ventricular tachycardia was inducible after procainamide underwent serial electrophysiologic studies . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
30,
41
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
131,
154
]
} |
in vivo and in vitro plasma disappearance and metabolism of somatostatin-28 and somatostatin-14 in the rat . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
60,
75
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
80,
95
]
} |
infusion of angiotensin ii into the kidney at 0.1 microgram/min reduced urine output by 50 % and was totally inhibited by simultaneous infusion of 0.07 micrograms/kg x min saralasin . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
12,
26
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
172,
181
]
} |
this antibody , which is an igg1 isotype , does not appreciably inhibit an acidic , thiol-dependent proteinase obtained from the adult stage of schistosoma mansoni . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
5,
13
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
33,
40
]
} |
during the biosynthesis of the dr antigens , the oligosaccharides on both subunits are initially high-mannose-type glycans , as has been found for other membrane glycoproteins . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
49,
65
]
} | {
"id": "C0032594",
"name": "glycans",
"pos": [
115,
122
]
} |
the light chain oligosaccharide and one of the two heavy chain carbohydrates are later processed to complex-type glycans . | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
16,
31
]
} | {
"id": "C0032594",
"name": "glycans",
"pos": [
113,
120
]
} |
further direct binding enzyme-linked immunoassays ( elisa ) and solid-phase immunoabsorption experiments with monoclonal antibodies to human anti-hla-dr framework determinants and a constant region of the igm mu-chain demonstrated determinants on the 70k factor recognized by these antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
110,
131
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
282,
292
]
} |
this study also contains the first direct evidence for the existence of reaginic antibody ( or antibodies ) in an ectothermic vertebrate . | NA | {
"id": "C0034761",
"name": "reaginic antibody",
"pos": [
72,
89
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
95,
105
]
} |
we also found , however , that the h-2k antigens of lt-85 tumor cells were clearly different from the h-2k antigens of allogeneic c3h spleen cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
31,
34
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
119,
129
]
} |
the h-2k antigens of lt-85 cells are therefore foreign to syngeneic c3hf cells , but do not represent expression by the tumor cells of the allogeneic h-2k antigens expressed by normal c3h cells . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
9,
17
]
} | {
"id": "C0003335",
"name": "tumor",
"pos": [
120,
125
]
} |
the h-2k antigens of lt-85 cells are therefore foreign to syngeneic c3hf cells , but do not represent expression by the tumor cells of the allogeneic h-2k antigens expressed by normal c3h cells . | NA | {
"id": "C3485979",
"name": "cells",
"pos": [
27,
32
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
177,
183
]
} |
only one of these mab , the mab art18 , showed characteristics of a putative anti-il 2 receptor antibody . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
18,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
96,
104
]
} |
cba/j ( h-2k , mls d ) responder mice are unable to develop ctl after an allogeneic footpad immunization if they are pretreated i.p . with spleen cells from either c3h/hen ( h-2k , mls c ) or b10.br ( h-2k , mls b ) mice . | NA | {
"id": "C3485979",
"name": "ctl",
"pos": [
60,
63
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
146,
151
]
} |
the antibodies are replacing conventional , polyclonal antisera in immunologic assays and are being widely applied to the study of the pathogenesis and to the diagnosis and treatment of childhood diseases . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
55,
63
]
} |
both the flush and the organic psychosis were reversed entirely by naloxone or naltrexone , and the hallucinosis could be reversed by vasodilators . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
67,
75
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
79,
89
]
} |
medullary carcinoma of the thyroid may occur in three patient groups : multiple endocrine neoplasia , type 2b ( men2b ) , men2a , and sporadic . | NA | {
"id": "C0027662",
"name": "multiple",
"pos": [
71,
79
]
} | {
"id": "C0025268",
"name": "men2a",
"pos": [
122,
127
]
} |
indications for surgical exploration based on the clinical finding of a bruit and/or thrill , ischemia , absent , pulse , shock , hemorrhage , neurologic deficit , hematoma , and proximity resulted in a rate of positive surgical exploration results of between 20 % and 100 % . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
130,
140
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
164,
172
]
} |
the effects of the supplementation of these media with serine , glutamine , glucosamine , and n-acetylglucosamine ( 0.1mm ) on cell growth were determined . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
76,
87
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
94,
113
]
} |
the growth of cells in the presence of glucosamine ( 0mm to 2mm ) and n-acetylglucosamine ( 1mm ) was monitored . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
39,
50
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
70,
89
]
} |
in the six patients with uncontrolled epilepsy , two patients had one more seizure per month while receiving baclofen , and a third went from four seizures per month to one per month . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
38,
46
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
147,
155
]
} |
using rhodamine-labelled antibodies directed against gamma-globin , fetal erythrocytes can be identified in fetal blood samples contaminated with maternal cells , and using fluorescein-labelled antibodies directed against beta-globin , the presence of beta-chains ( and thus hb-a ) may be determined in the same cells by... | NA | {
"id": "C0017033",
"name": "gamma-globin",
"pos": [
53,
65
]
} | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
222,
233
]
} |
no inhibitory effect on thrombin activity , fibrinopeptide a release or on the fibrin cross-linking reaction of factor xiiia could be detected . | NA | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
44,
60
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
79,
85
]
} |
purified patient fibrinogen was functionally normal as demonstrated by normal fibrinogen-fibrin polymerization and fibrinopeptide a release . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
17,
23
]
} | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
115,
131
]
} |
endothelial cells from human umbilical veins produce a procoagulant identified as thromboplastin ( tissue factor , factor iii ) when stimulated with the phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate ( tpa ) , phytohaemagglutinin ( pha ) or endotoxin , inducible thromboplastin synthesis ( i.e . synthesis of the pr... | NA | {
"id": "C0031586",
"name": "phorbol",
"pos": [
153,
160
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
186,
193
]
} |
endothelial cells from human umbilical veins produce a procoagulant identified as thromboplastin ( tissue factor , factor iii ) when stimulated with the phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate ( tpa ) , phytohaemagglutinin ( pha ) or endotoxin , inducible thromboplastin synthesis ( i.e . synthesis of the pr... | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
356,
366
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
456,
463
]
} |
of the total thromboplastin activity in homogenates of stimulated endothelial cells , about 50 -- 70 % was available on the cell surface for interaction with other coagulation factors , inactivation by trypsin and neutralization with antiserum against apoprotein iii . | NA | {
"id": "C0040048",
"name": "thromboplastin",
"pos": [
13,
27
]
} | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
164,
183
]
} |
the surface antigen phenotype of 30 patients with the blast phase of chronic myeloid leukemia ( cml ) was determined using a panel of monoclonal antibodies recognizing differentiation antigens of normal myeloid , erythroid , megakaryocyte , and lymphoid cells . | NA | {
"id": "C0003339",
"name": "surface antigen",
"pos": [
4,
19
]
} | {
"id": "C0003324",
"name": "differentiation antigens",
"pos": [
168,
192
]
} |
comparison of the microsomal activities of the tetrahydropteridine-dependent alkyl-cleavage enzyme present in astrocytoma 78-fr-g-299 cells and the pleomorphic glioma 78-fr-g-219/s4 cells to that found in normal skin fibroblasts and rat livers revealed a markedly reduced activity in the neoplastic cell lines . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
14,
17
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
217,
228
]
} |
the class i antibody , np-1 , recognized an epitope shared among all three antigens , and its affinity for cea and ma was high but low for nonspecific cross-reacting antigen . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
44,
51
]
} | {
"id": "C0003320",
"name": "ma",
"pos": [
115,
117
]
} |
the class iii antibody , np-4 , bound less than 50 % of the cea molecules recognized by goat specific anti-cea antibody and the other classes of monoclonal antibodies . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
14,
22
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
145,
166
]
} |
one of the monoclonal antibodies , np-1 , recognizes a cea epitope shared with the nonspecific cross-reacting antigen and meconium antigen . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
59,
66
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
131,
138
]
} |
two others , np-2 and np-3 , discriminate two separate cea epitopes shared with meconium antigen only , whereas np-4 reacts with a unique determinant expressed on a subpopulation of cea molecules . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
59,
67
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
89,
96
]
} |
experiments on passive swelling show that mitochondria from ascites tumor cells have an enhanced permeability to chloride salts of monovalent cations and increased activity of the na+ ( k+ ) -h+ exchange system of the mitochondrial membrane with respect to normal mitochondria . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
131,
149
]
} | {
"id": "C0033727",
"name": "h",
"pos": [
269,
270
]
} |
studying the quantitative immunonephelometric determination of apolipoprotein a-1 ( apo a-1 ) , we observed that the different particle sizes of lipoproteins must be taken into account in immunonephelometry if apo a-1 is a constituent of the lipoprotein particles . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
145,
157
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
255,
256
]
} |
the concentration of secretory immunoglobulin a can be determined with a minimum detectable sensitivity of 3 mg/l , without interference from free immunoglobulin a and secretory component in the same samples . | NA | {
"id": "C0020838",
"name": "secretory immunoglobulin a",
"pos": [
21,
47
]
} | {
"id": "C0020835",
"name": "immunoglobulin a",
"pos": [
147,
163
]
} |
however , the antibody does cross react , essentially completely , with the digoxin hydrolysis metabolites digoxigenin , digoxigenin mono-digitoxide , and digoxigenin bis-digitoxide . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
76,
83
]
} | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
155,
166
]
} |
we studied the pattern of acute-phase proteins ( orosomucoid , c-reactive protein , and haptoglobin ) in hepatocellular deficiency due to chronic alcohol consumption , characterized by a decrease in serum transferrin concentration . | NA | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
26,
46
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
49,
60
]
} |
we studied the pattern of acute-phase proteins ( orosomucoid , c-reactive protein , and haptoglobin ) in hepatocellular deficiency due to chronic alcohol consumption , characterized by a decrease in serum transferrin concentration . | NA | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
26,
46
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
63,
81
]
} |
we studied the pattern of acute-phase proteins ( orosomucoid , c-reactive protein , and haptoglobin ) in hepatocellular deficiency due to chronic alcohol consumption , characterized by a decrease in serum transferrin concentration . | NA | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
26,
46
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
88,
99
]
} |
we studied the pattern of acute-phase proteins ( orosomucoid , c-reactive protein , and haptoglobin ) in hepatocellular deficiency due to chronic alcohol consumption , characterized by a decrease in serum transferrin concentration . | NA | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
26,
46
]
} | {
"id": "C0040679",
"name": "transferrin",
"pos": [
205,
216
]
} |
in moderate hepatocellular deficiency , acute-phase proteins are increased independently of the decrease in transferrin , whereas in severe hepatocellular deficiency the acute-phase proteins are also decreased . | NA | {
"id": "C0040679",
"name": "transferrin",
"pos": [
108,
119
]
} | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
170,
190
]
} |
detection of heterozygote carriers for congenital adrenal hyperplasia by use of a modified tetracosactide ( a synthetic corticotropin ) stimulation test with prior overnight dexamethasone suppression proved to have a diagnostic accuracy of 95 % . | NA | {
"id": "C0010192",
"name": "tetracosactide",
"pos": [
91,
105
]
} | {
"id": "C0001655",
"name": "corticotropin",
"pos": [
120,
133
]
} |
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