text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in a 21-year-old woman with mccune-albright syndrome , acromegaly and hyperprolactinemia with hypopituitarism developed secondary to a large pituitary tumor . | NA | {
"id": "C0020635",
"name": "hypopituitarism",
"pos": [
94,
109
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
141,
150
]
} |
the incorporation into acid-insoluble macromolecules of the amino sugar glucosamine , the first and committed metabolite in the biosynthetic sequence , and its immediate derivative , n-acetyl glucosamine was determined . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
72,
83
]
} | {
"id": "C0001056",
"name": "n-acetyl glucosamine",
"pos": [
183,
203
]
} |
isolated angiitis of the central nervous system is an uncommon clinicopathologic entity characterized by vasculitis restricted to the vessels of the central nervous system without other apparent systemic vasculitis . | NA | {
"id": "C0042384",
"name": "vasculitis",
"pos": [
105,
115
]
} | {
"id": "C0264939",
"name": "systemic vasculitis",
"pos": [
195,
214
]
} |
clinical observations made on a group of six children and three adults indicate that ketoconazole is a safe and effective fungistatic agent that is useful for both initial and long-term maintenance therapy of mucocutaneous lesions due to infection by sensitive strains of candida in patients with chronic mucocutaneous c... | NA | {
"id": "C0006840",
"name": "infection",
"pos": [
238,
247
]
} | {
"id": "C0006845",
"name": "chronic mucocutaneous",
"pos": [
297,
318
]
} |
5-fluorocytosine and imidazoles , such as miconazole and ketoconazole , have been shown to be active , mainly on yeast organisms . | NA | {
"id": "C0020924",
"name": "imidazoles",
"pos": [
21,
31
]
} | {
"id": "C0025942",
"name": "miconazole",
"pos": [
42,
52
]
} |
the pregnant dogs inoculated with either of these concentrates progressively developed hypertension , eyeground changes consistent with hypertensive retinopathy , proteinuria , disseminated intravascular coagulation , and hepatic dysfunction in addition to intrauterine growth retardation and intrauterine fetal death . | NA | {
"id": "C0020538",
"name": "hypertension",
"pos": [
87,
99
]
} | {
"id": "C0152132",
"name": "hypertensive retinopathy",
"pos": [
136,
160
]
} |
the plasma concentrations of total testosterone , free testosterone index , androstenedione , 17 beta-estradiol , luteinizing hormone , follicle-stimulating hormone , prolactin , and urinary 17-ketosteroid and 17-ketogenic steroid excretion were measured in 48 nonhirsute and 119 hirsute patients . | NA | {
"id": "C0002860",
"name": "androstenedione",
"pos": [
76,
91
]
} | {
"id": "C0000167",
"name": "17-ketosteroid",
"pos": [
191,
205
]
} |
( 2 ) body weight correlated with adrenal adrogens ( 17-ketosteroids ) in nonhirsute women and with androstenedione in hirsute women ; | NA | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
53,
68
]
} | {
"id": "C0002860",
"name": "androstenedione",
"pos": [
100,
115
]
} |
( 3 ) prednisone significantly suppressed androstenedione and 17-ketosteroids ( p less than 0.05 ) , with a decline of testosterone to 65 % and luteinizing hormone to 51 % of pretreatment values , with favorable clinical effects on the hirsutism , menstrual dysfunction , and infertility ; | NA | {
"id": "C0002860",
"name": "androstenedione",
"pos": [
42,
57
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
62,
77
]
} |
sixty-two patients who complained of urinary incontinence had the following primary diagnoses : genuine stress incontinence ( 36 % ) , unstable bladder ( 29 % ) , urethral syndrome ( 21 % ) , and pelvic relaxation ( 5 % ) . | NA | {
"id": "C0042024",
"name": "urinary incontinence",
"pos": [
37,
57
]
} | {
"id": "C0042025",
"name": "genuine",
"pos": [
96,
103
]
} |
in addition , the concentrations of various lipids were analyzed for alterations in membrane lipid composition . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
44,
50
]
} | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
84,
98
]
} |
successful treatment of severe skeletal open-bite malocclusions has always demanded the utmost of the orthodontist . | NA | {
"id": "C0266061",
"name": "open-bite",
"pos": [
40,
49
]
} | {
"id": "C0024636",
"name": "malocclusions",
"pos": [
50,
63
]
} |
in addition , differences were noted when the time kinetics of acute responses induced by two different mediators ( 10 ( -4 ) m fmlp , a synthetic preformed chemotactic factor ; | NA | {
"id": "C0027229",
"name": "fmlp",
"pos": [
128,
132
]
} | {
"id": "C0008013",
"name": "chemotactic factor",
"pos": [
157,
175
]
} |
the lung content of protein , proline , and hydroxyproline ( collagen ) were quantitated , as were the synthesis rates of lung collagen and the total lung protein ( evaluated with lung minces in vitro . the ratio of newly synthesized and of total lung type i to type iii collagen was also determined . these experiments ... | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
30,
37
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
44,
58
]
} |
renal venous outflow and urinary excretion of norepinephrine , epinephrine , and dopamine during graded renal nerve stimulation . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
46,
60
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
63,
74
]
} |
the effect of renal nerve stimulation ( rns ) on renal venous outflow and urinary excretion of endogenous norepinephrine , epinephrine , and dopamine was examined in anesthetized dogs . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
106,
120
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
123,
134
]
} |
infusion of the sodium salts of sulfate , a nonreabsorbable anion , did not correct the diminished u-b pco2 . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
32,
39
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
60,
65
]
} |
slow rise and diurnal change of blood pressure with saralasin and angiotensin ii in rats . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
52,
61
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
66,
80
]
} |
our objectives were to determine whether saralasin , like angiotensin ii , raises blood pressure gradually when given by constant infusion and whether either agent alters the diurnal variation of arterial pressure . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
41,
50
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
58,
72
]
} |
six other rats were infused with angiotensin ii ( 20 ng . kg-1 . min-1 ) instead of saralasin . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
33,
47
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
84,
93
]
} |
saralasin and angiotensin ii gradually raised map in all rats , by 22.0 mmhg on the 4th day of saralasin and by 41.7 mmhg on the 4th day of angiotensin ii . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
0,
9
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
140,
154
]
} |
variability of arterial pressure was also increased by saralasin and in an earlier experiment by angiotensin ii . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
55,
64
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
97,
111
]
} |
we conclude that saralasin has a slow pressor action similar to that of angiotensin ii but distinct in its timing both from the rapid agonist action of saralasin and from the acute vasoconstrictor action of angiotensin ii . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
17,
26
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
207,
221
]
} |
these effects of saralasin may compromise interpretation of experiments in which the drug is given by prolonged infusion to assess the role of angiotensin ii . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
17,
26
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
143,
157
]
} |
serotonin , pyrophosphate , adenosine 5'-monophosphate ( amp ) , and adenosine 5'-triphosphate ( atp ) were found not to be present in sufficient quantities to produce ifcs that could influence platelet aggregation if used alone at the ifc . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
28,
39
]
} | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
69,
80
]
} |
as dopamine can activate alpha- and beta-adrenergic receptors in addition to dopaminergic receptors , experiments were also performed to characterize the type of receptors involved in dopamine-induced renin release . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
77,
89
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
184,
192
]
} |
based on cross sectional data from a general population of 5,817 people aged 14 to 61 , objective overweight is compared with perceived overweight , and information is provided on morbidity due to being overweight , and on what people are doing to try to lose weight . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
98,
108
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
260,
266
]
} |
only about 7 per cent of those who perceive they are overweight are under a doctor 's care to lose weight . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
53,
63
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
99,
105
]
} |
hyper-ige immunoglobulinemia was observed in bronchial asthma , atopic dermatitis , eosinophilic granuloma of the soft tissue ( kimura 's disease ) , disseminated visceral eosinophilic granulomas ( zuelzer-apt syndrome ) and disseminated eosinophilic collagen disease , ige antibodies to environmental allergens ( dermat... | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
210,
218
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
555,
563
]
} |
the in vitro bactericidal activity of certain antimicrobials , especially aminoglycosides , is markedly diminished at an acid ph . | NA | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
46,
60
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
74,
89
]
} |
this relatively acid environment appears exaggerated within pneumonic airways and may contribute toward decreasing the effectiveness of aminoglycosides and certain other antimicrobials used in treating lung infection . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
136,
151
]
} | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
170,
184
]
} |
serum ige and igd concentrations were examined in 80 patients with recurrent aphthous stomatitis ( ras ) , 20 patients with other ulcerative oral disorders , and 39 control subjects . both ige and igd concentrations were substantially greater in patients with ras than in either the other patients with oral disorders or... | NA | {
"id": "C0149745",
"name": "ulcerative oral",
"pos": [
130,
145
]
} | {
"id": "C0026636",
"name": "oral disorders",
"pos": [
303,
317
]
} |
family history or presence of enthesopathic pain , psoriasis , inflammatory bowel disease , uveitis , recurrent urethritis , prostatitis or cervicitis , keratoderma blennorrhagicum , hla-b27 , and asymmetric pauciarticular lower lower extremity arthritis without rheumatoid factor or rheumatoid nodules suggests a diagno... | NA | {
"id": "C0035450",
"name": "rheumatoid nodules",
"pos": [
284,
302
]
} | {
"id": "C0003873",
"name": "ra",
"pos": [
342,
344
]
} |
the clinical , biochemical , and pathologic findings in 43 patients with primary hyperparathyroidism ( hpt ) and a history of irradiation to the head or neck were compared with those found in a group of 162 patients with hpt without prior irradiation . | NA | {
"id": "C0221002",
"name": "primary",
"pos": [
73,
80
]
} | {
"id": "C0020502",
"name": "hpt",
"pos": [
221,
224
]
} |
we tested the requirement for the individual antimicrobial activities of sulfadiazine and silver for the vitro activity of sulfadiazine silver . | NA | {
"id": "C0038675",
"name": "sulfadiazine",
"pos": [
73,
85
]
} | {
"id": "C0037134",
"name": "silver",
"pos": [
136,
142
]
} |
the ultrastructural aspects of these inclusions suggested that they are residual bodies containing lipid and lipofuscin . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
99,
104
]
} | {
"id": "C0023789",
"name": "lipofuscin",
"pos": [
109,
119
]
} |
prevention of late fentanyl-induced respiratory depression after the injection of opiate antagonists naltrexone and s-20682 : comparison with naloxone . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
101,
111
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
142,
150
]
} |
compared with naloxone , two opiate antagonists ( naltrexone and s-20682 ) were tested in the intact dog in order to reverse respiratory depression , induced by fentanyl 50 micrograms kg-1 i.v . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
14,
22
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
50,
60
]
} |
only s-20682 , but not naloxone or naltrexone , prevented late ( 240 min ) fentanyl-induced depression of respiratory drive . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
23,
31
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
35,
45
]
} |
isophosphoramide mustard was synthesized and was found to demonstrate activity essentially comparable to cyclophosphamide and ifosfamide against l1210 and p388 leukaemia . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
105,
121
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
126,
136
]
} |
treatment of mice with drug followed by l1210 cells demonstrated a shorter duration of effective levels of cytotoxic activity for isophosphoramide mustard and phosphoramide mustard in comparison with cyclophosphamide and ifosfamide . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
200,
216
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
221,
231
]
} |
these studies indicate that conjugation of a cytotoxic agent to a monoclonal antibody can confer on that agent selectivity for a particular target cell type which is recognised by the antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
66,
85
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
184,
192
]
} |
in different experiments , colony-stimulating factor ( csf ) was added to stimulated granulocyte-macrophage colony-forming cells ( gm-cfc ) , erythropoietin was used to induce erythroid burst ( bfu-e ) formation or erythropoietin and medium conditioned by leucocytes in the presence of phytohaemagglutinin ( pha-lcm ) wa... | NA | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
27,
52
]
} | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
215,
229
]
} |
the variability was computed as an arbitrary index during a 20-min period preceding a fetal scalp blood sample which was used for the measurement of ph , adrenaline and noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
154,
164
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
169,
182
]
} |
gross utilization of any nefa and appearance of 14co2 across the muscle were linearly related to the arterial concentration of tracer fatty acid , irrespective of whether this was oleate or stearate . | NA | {
"id": "C0015688",
"name": "nefa",
"pos": [
25,
29
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
134,
144
]
} |
biochemical analysis of gags from leukemic myeloblasts containing primary granules and auer rods , but lacking secondary and tertiary granules , revealed 8 x 10 ( -17 ) mole of uronic acid/cell and electrophoretic and sulfaminohexose analysis showed 60 % -70 % chondroitin sulfate ac of heterogeneous molecular weight , ... | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
24,
28
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
368,
383
]
} |
the lack of significant hid-tch-sp staining of sulfate iin sites other than auer rods and primary granules in leukemic myeloblasts indicates that these granules contain the chondroitin , dermatan , and heparan sulfate isolated from the same specimen . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
173,
184
]
} | {
"id": "C0011602",
"name": "dermatan",
"pos": [
187,
195
]
} |
subconfluent cultures of cells are fibroblast-appearing , but in confluent cell sheets , prominent foci of lipid-containing cells develop in both uncloned and four separate cloned cell lines . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
35,
45
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} |
cell samples from 62 patients with b-cell leukemias ( 33 cll , 8 ic , 6 pll , 4 hcl , 2 all and 9 other nhl ) were tested with a series of monoclonal antibodies ( a50 , t101 , lyt2 , leu 1 , m203 ) directed against t cells and shown to crossreact with b-cll . | NA | {
"id": "C2004493",
"name": "b-cell leukemias",
"pos": [
35,
51
]
} | {
"id": "C0023434",
"name": "cll",
"pos": [
254,
257
]
} |
the results demonstrate a heterogeneity of b-cell leukemias as all typical cases of cll were reactive whereas most other cases were negative . | NA | {
"id": "C2004493",
"name": "b-cell leukemias",
"pos": [
43,
59
]
} | {
"id": "C0023434",
"name": "cll",
"pos": [
84,
87
]
} |
the decrease in t-cfu varied between histologic tumor types and between tumor of the same type . | NA | {
"id": "C0027651",
"name": "t-cfu",
"pos": [
16,
21
]
} | {
"id": "C0027652",
"name": "histologic tumor types",
"pos": [
37,
59
]
} |
human cg-alpha-immunoreactive cells were present in 42 of 56 ( 75 % ) functioning malignant pancreatic endocrine tumors but in only one , possibly benign , glucagonoma of 67 functioning benign tumors , in only one of 17 nonfunctioning malignant and in none of 17 nonfunctioning benign tumors . | NA | {
"id": "C1328479",
"name": "malignant pancreatic endocrine tumors",
"pos": [
82,
119
]
} | {
"id": "C0017689",
"name": "glucagonoma",
"pos": [
156,
167
]
} |
testing of pretreatment patient sera in an indirect immunofluorescence assay against both autologous normal fibroblasts and autologous osteosarcoma cells showed cytoplasmic staining . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
108,
119
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
148,
153
]
} |
in the primary culture , host fibroblasts were eliminated by the use of the antiserum raised against nude mouse cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
30,
41
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
112,
117
]
} |
however , plasma levels of anti-xa were often low ( less than 70 % ) and increased only in the presence of heparin . | NA | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
27,
34
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
107,
114
]
} |
in addition to previously better understood causes of anemia in cll , the uncommon occurrence of prca is an additional consideration in the differential diagnosis of sudden anemia in cll . | NA | {
"id": "C0034902",
"name": "prca",
"pos": [
97,
101
]
} | {
"id": "C0002871",
"name": "anemia",
"pos": [
173,
179
]
} |
levels of copper , haptoglobin , fibrinogen and factor viii were measured in 30 patients with non-hodgkin 's lymphoma on 90 occasions in an attempt to demonstrate a possible correlation between hypercupremia and other acute phase reactants . | NA | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
19,
30
]
} | {
"id": "C0001347",
"name": "acute phase",
"pos": [
218,
229
]
} |
levels of copper , haptoglobin , fibrinogen and factor viii were measured in 30 patients with non-hodgkin 's lymphoma on 90 occasions in an attempt to demonstrate a possible correlation between hypercupremia and other acute phase reactants . | NA | {
"id": "C0016006",
"name": "fibrinogen",
"pos": [
33,
43
]
} | {
"id": "C0001347",
"name": "acute phase",
"pos": [
218,
229
]
} |
effect of dental plaque on fluoride uptake by enamel from a sodium fluoride varnish in vivo . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
27,
35
]
} | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
60,
75
]
} |
patients in the scar group ( n = 5 ) had prior infarction , akinetic scars and no ischemia with exercise . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
47,
57
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
82,
90
]
} |
hemodynamic studies on the effects of i.v . ergotamine tartrate ( 0.25-0.50 mg ) revealed that the ergotamine-induced increase in blood pressure in the supine position was associated with an increase in total peripheral resistance ( from 1616 +/- 165 to 2574 +/- 583 u ) without a change in cardiac output . | NA | {
"id": "C0086248",
"name": "ergotamine tartrate",
"pos": [
44,
63
]
} | {
"id": "C0014710",
"name": "ergotamine",
"pos": [
99,
109
]
} |
prolactin was radiolabeled by the chloramine t method , purified by each of the above procedures , and the binding and displacement characteristics were studied in radioimmunoassays in which either monoclonal antibodies or a rabbit anti-prolactin serum was the first antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
198,
219
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
267,
275
]
} |
after incubation , suitable dilutions of sera or extract plus antiserum , conjugate , and double antibody were filtered on an estradiol affinity gel-filtration column ; | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
62,
71
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
97,
105
]
} |
the linearity , sensitivity , and precision are satisfactory and the reactivity of benzethonium chloride with various proteins ( albumin , immunoglobulins ) is the same . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
118,
126
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
129,
136
]
} |
19 : 1309-1313 , 1973 ) for plasma cholinesterase ( ec 3.1.1.7 ) gives a background absorbance of 1.4 a when extended to erythrocyte cholinesterase ( ec 3.1.1.8 ) measurement , because the peak absorbance of the reaction product , 5-thionitrobenzoate , coincides with the hemoglobin soret band at 410 nm . | NA | {
"id": "C0008429",
"name": "plasma",
"pos": [
28,
34
]
} | {
"id": "C0001044",
"name": "erythrocyte cholinesterase",
"pos": [
121,
147
]
} |
thus erythrocyte cholinesterase measurements can readily be made , to complement plasma cholinesterase in the investigation of exposure to organophosphates . | NA | {
"id": "C0001044",
"name": "erythrocyte cholinesterase",
"pos": [
5,
31
]
} | {
"id": "C0008429",
"name": "plasma cholinesterase",
"pos": [
81,
102
]
} |
the combination of juvenile nephronophthisis and tapeto-retinal degeneration , renal-retinal dystrophy , may cause blindness in infancy , and renal failure in the first decade of life . | NA | {
"id": "C0035304",
"name": "retinal degeneration",
"pos": [
56,
76
]
} | {
"id": "C0854723",
"name": "retinal",
"pos": [
85,
92
]
} |
bretylium kinetics were examined in patients with varying degrees of renal impairment after a single intravenous dose of bretylium tosylate . | NA | {
"id": "C0054040",
"name": "kinetics",
"pos": [
10,
18
]
} | {
"id": "C0006168",
"name": "bretylium tosylate",
"pos": [
121,
139
]
} |
guanabenz induced reduction in plasma catecholamines subjects in all positions and the reduction correlated with the placebo level for both norepinephrine and epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
140,
154
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
159,
170
]
} |
the results suggest that the biliary tract antigens are probably not related to 'common ' antigenic determinants associated with the hla system . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
43,
51
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
90,
112
]
} |
sulphide anion , on the other hand , inhibited amlev synthase activity 85 % at 10 mmol/l concentration . | NA | {
"id": "C0038739",
"name": "sulphide",
"pos": [
0,
8
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
9,
14
]
} |
factors which increase angiotensin ii levels , such as sodium restriction , isometric exercise and angiotensin infusion , selectively increase 18-ohb and aldosterone , suggesting that angiotensin ii increases 18-ohb and aldosterone secretion , in part , by modulation of the 18-hydroxylation reaction involved in convers... | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
23,
34
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
184,
198
]
} |
it is concluded that the catabolic response to severe injury is consistent with increased rates of plasma amino acid appearance and branched chain amino acid administration spares body protein by improving amino acid utilization for whole body protein synthesis . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
106,
116
]
} | {
"id": "C0002521",
"name": "branched chain amino acid",
"pos": [
132,
157
]
} |
activities of enzymes implicated in bicarbonate secretion , hco3 -- activated atpase , carbonic anhydrase and na+ + k+-activated atpase , were measured in the duodenal mucosa of control rats and animals 24 h after subcutaneous administration of cysteamine . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
78,
84
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
164,
166
]
} |
clonidine was injected into the vertebral and carotid arteries , and its effects were compared with those of norepinephrine and epinephrine when injected into the third ventricle . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
109,
123
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
128,
139
]
} |
beta-endorphin and related opioid peptides are neuropeptides which appear to play a role in cardiovascular regulation which is supported by altered nociceptive responsiveness in hypertensive animals . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
27,
42
]
} | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
47,
60
]
} |
to study the structure and the molecular mechanisms of action of brain alpha-adrenoceptors , their solubilization was undertaken . alpha 1-adrenoceptors were first successfully solubilized from fresh rat brain membranes by treatment with 0.3 percent deoxycholate , after prelabeling of the binding site by the highly spe... | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
71,
90
]
} | {
"id": "C0001638",
"name": "alpha 1-adrenoceptors",
"pos": [
131,
152
]
} |
quantification of the degree of cell spreading of human fibroblasts by semi-automated analysis of the cell perimeter . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
56,
67
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
102,
106
]
} |
one hundred twenty-six patients with a clinical diagnosis of chronic , diffuse , well-compensated liver disease were randomized into two groups and submitted either to percutaneous blind liver biopsy ( pb : 64 patients ) or to laparoscopy with guided biopsy ( lb : 62 patients ) , in order to assess the accuracy of eith... | NA | {
"id": "C0023895",
"name": "of",
"pos": [
58,
60
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
347,
356
]
} |
parenteral administration of beta- ( p-chlorophenyl ) -gamma-aminobutyric acid ( pcp-gaba ) , a lipophilic gaba mimetic , has been shown to aggravate stress-induced ulcerations in the rat . | NA | {
"id": "C0004609",
"name": "pcp-gaba",
"pos": [
81,
89
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
107,
111
]
} |
comparative anatomical cross-sections showed that the major normal structures and pathological processes like hemorrhage , tumors , infarctions and edema are displayed . | NA | {
"id": "C0030660",
"name": "pathological",
"pos": [
82,
94
]
} | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
110,
120
]
} |
bleeding complications , included postoperative blood loss ( more than 500 ml ) , unusually marked bleeding from drains , seroma , wound haematoma , and re-operation . | NA | {
"id": "C0032788",
"name": "postoperative blood loss",
"pos": [
34,
58
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
99,
107
]
} |
complementation of human growth hormone ( gh ) peptide 1-134 with c-terminal fragments of human gh produced by digestion with bromelain . | NA | {
"id": "C0037663",
"name": "human growth hormone",
"pos": [
19,
39
]
} | {
"id": "C0169964",
"name": "human gh",
"pos": [
90,
98
]
} |
the presence of other hormones in the culture medium was not a prerequisite for the corticosteroid action . | NA | {
"id": "C0019932",
"name": "hormones",
"pos": [
22,
30
]
} | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
84,
98
]
} |
these findings fit with the proposition that glicentin fulfills the role of proglucagon in the pancreas , and is the major component of enteroglucagon in the intestine . | NA | {
"id": "C0061309",
"name": "glicentin",
"pos": [
45,
54
]
} | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
76,
87
]
} |
multiplication-stimulating activity , a family of insulin-like growth factors previously identified in medium conditioned by the brl-3a rat liver cell line , is also synthesized by third passage cultures of rat embryo fibroblasts ( refs ) maintained in serum-free medium . | NA | {
"id": "C0021666",
"name": "multiplication-stimulating activity",
"pos": [
0,
35
]
} | {
"id": "C0037657",
"name": "insulin-like growth factors",
"pos": [
50,
77
]
} |
in receptor binding assays using refs , chick embryo fibroblasts , swarm rat chondrosarcoma cells , and rat liver membranes , ref msa was equal to brl msa in competition for binding of [ 125i ] iodo-msa . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
53,
64
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
92,
97
]
} |
in patients with liver cirrhosis endotoxaemia occurred more often than in patients without liver disease . | NA | {
"id": "C0023890",
"name": "liver",
"pos": [
17,
22
]
} | {
"id": "C0023895",
"name": "liver",
"pos": [
91,
96
]
} |
the washington psychosocial seizure inventory ( wpsi ) was used to evaluate the relative extent of psychosocial problems in 379 adults with epilepsy , having differing levels of intelligence and neuropsychological impairment . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
28,
35
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
140,
148
]
} |
this anticonvulsant property of ne was shared by the alpha receptor agonists 6-fluoro-norepinephrine , l-alpha-methyl-norepinephrine , and clonidine , but not by d-alpha-methyl-norepinephrine or l-phenylephrine . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
32,
34
]
} | {
"id": "C0025805",
"name": "alpha-methyl-norepinephrine",
"pos": [
164,
191
]
} |
however , concentrations of acetyl coa and long-chain acyl coa compounds did not change significantly in axotomized ganglia . | NA | {
"id": "C0001026",
"name": "acetyl coa",
"pos": [
28,
38
]
} | {
"id": "C0001374",
"name": "long-chain acyl coa",
"pos": [
43,
62
]
} |
these results indicate that the blood-brain barrier is virtually impermeable for ala , although the amino acid may enter the cerebrospinal fluid via fenestrated capillaries of the circumventricular organs and tanycytes of the median eminence . | NA | {
"id": "C0002563",
"name": "ala",
"pos": [
81,
84
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
100,
110
]
} |
nitrendipine is a calcium antagonistic 1,4-dihydropyridine derivative with a pronounced antihypertensive activity in animal experiment . | NA | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
0,
12
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
43,
58
]
} |
however , depending on the concentration and the time interval between its addition and that of another agonist , 5-ht amplifies the human platelet aggregation induced by adp , collagen , epinephrine , and norepinephrine ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
188,
199
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
206,
220
]
} |
structurally different beta 1- and beta 2-adrenergic receptors have been purified with a single monoclonal antibody affinity column , where the antibody is specific for an epitope in the ligand-binding site of both beta 1 and beta 2 receptors . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
96,
115
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
144,
152
]
} |
the activities of acyl-coa hydrolase , catalase , urate oxidase and peroxisomal palmitoyl-coa oxidation as well as the protein content and the level of coash and long-chain acyl-coa were measured in subcellular fractions of liver from rats fed diets containing phenobarbital ( 0.1 % w/w ) or clofibrate ( 0.3 % w/w ) . | NA | {
"id": "C0030239",
"name": "palmitoyl-coa",
"pos": [
80,
93
]
} | {
"id": "C0001374",
"name": "long-chain acyl-coa",
"pos": [
162,
181
]
} |
the existence of separate peroxisomal pools of free coenzyme a and long-chain acyl-coa in rat liver , demonstrated by a specific high performance liquid chromatography method . | NA | {
"id": "C0009226",
"name": "coenzyme a",
"pos": [
52,
62
]
} | {
"id": "C0001374",
"name": "long-chain",
"pos": [
67,
77
]
} |
hog gastric mucin was resistant to pancreatic proteases : less than 10 % of the mucin protein became soluble in 80 % vol/vol ethanol after 24-h incubation with trypsin , alpha-chymotrypsin , and elastase , and its elution pattern from sephadex g-200 remained unchanged after elastase treatment , with 90 % eluting at the... | NA | {
"id": "C0017135",
"name": "gastric mucin",
"pos": [
4,
17
]
} | {
"id": "C0026682",
"name": "mucin",
"pos": [
80,
85
]
} |
the suppressor cell activity determined by the ability of concanavalin a-activated cells to suppress blast transformation of splenic cells of normal sma mice was significantly decreased ( p less than 0.05 ) in mice immunized with a mixture of liver-specific lipoprotein and the polysaccaride of klebsiella pneumoniae com... | NA | {
"id": "C0065058",
"name": "a",
"pos": [
20,
21
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
458,
469
]
} |
cytochemical studies suggest that na+ , k+-atpase is localized to sinusoidal and lateral portions of the hepatocyte plasma membrane whereas mg++-atpase and alkaline phosphatase are luminal or canalicular membrane markers . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
34,
36
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
145,
151
]
} |
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