text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
c , 6 micrograms/kg/day , reduced the ratio of norepinephrine ( ne ) metabolites ( mumol/24 hr ) to normetanephrine ( nm ) , vanillylmandelic acid ( vma ) , and 3-methoxy-4-hydroxyphenyl glycol ( mhpg ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
47,
61
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
100,
115
]
} |
reduction in nm/ ( vma + mhpg ) indicates disproportionate lowering of the o-methylated metabolite of ne compared to its deaminated metabolites , consistent with c inhibition of ne release . | NA | {
"id": "C0028385",
"name": "nm",
"pos": [
13,
15
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
178,
180
]
} |
c-induced reductions in the ratio nm/ ( vma + mhpg ) , an index of ne release , correlated ( n = 7 ) with reductions in supine systolic blood pressure , mean arterial pressure , and salivary flow rate . | NA | {
"id": "C0028385",
"name": "nm",
"pos": [
34,
36
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
124,
126
]
} |
these data suggest that both histamine acting through h1- and h2-receptors and prostaglandins may influence liver blood flow in man and are consistent with evidence from animal experiments that suggest a role for prostaglandins in h2-mediated vascular responses . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
79,
93
]
} | {
"id": "C0033555",
"name": "a",
"pos": [
249,
250
]
} |
the neuromuscular tracings and sequential physician exams done before and after administering gentamicin suggest aminoglycosides may potentiate a magnesium-induced impairment of neuromuscular transmission and cause muscular weakness in neonates . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
94,
104
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
113,
128
]
} |
the present report describes a patient with osteomyelitis of both clavicles due to subclavian vein venipuncture , in whom fever and chills were absent and the sole clinical finding was local pain and tenderness in the involved area . | NA | {
"id": "C0085593",
"name": "chills",
"pos": [
132,
138
]
} | {
"id": "C0037088",
"name": "clinical finding",
"pos": [
164,
180
]
} |
the increased echo density was considered to represent fibrosis and scar formation as a result of ischemia and infarction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
98,
106
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
111,
121
]
} |
adenine-derived purines increase adenosine triphosphate ( atp ) levels in the luteal cell : evidence that cell levels of atp may limit the stimulation of adenosine 3',5'-monophosphate accumulation by luteinizing hormone . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
0,
7
]
} | {
"id": "C0034140",
"name": "purines",
"pos": [
16,
23
]
} |
the iv injection of asp1 , val5-angiotensin ii ( aii ) was followed by increases in arterial plasma norepinephrine ( ne ) and epinephrine ( e ) concentrations and elevation of arterial blood pressure in the anesthetized pekin duck . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
100,
114
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
126,
137
]
} |
as the polynucleotide domain of the estrogen receptor ( re ) is a possible site for the modulation of re activity , the interaction of antiestrogen ( 4-hydroxytamoxifen and tamoxifen ) -receptor complexes ( 4-oh-tam-re and tam-re ) with polynucleotides ( oligodeoxynucleotide-cellulose , dna-cellulose , and polyribonucl... | NA | {
"id": "C0034804",
"name": "estrogen receptor",
"pos": [
36,
53
]
} | {
"id": "C0034803",
"name": "17",
"pos": [
384,
386
]
} |
the molluscan neuropeptide fmrfamide ( phe-met-arg-phe-nh2 ) has diverse actions on excitable tissues of molluscs , including hearts , noncardiac muscles , complex organs , and neurons . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
14,
26
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
27,
36
]
} |
influence of human chorionic gonadotropin in vivo on steroid formation and gonadotropin responsiveness of isolated human preovulatory follicular cells . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
13,
41
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
75,
87
]
} |
effect of metabolic control on lipid , lipoprotein , and apolipoprotein levels in 55 insulin-dependent diabetic patients . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
31,
36
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
60,
71
]
} |
diabetic rats had basal glucagon levels higher than those in control rats , while basal epinephrine and norepinephrine levels were essentially identical . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
88,
99
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
104,
118
]
} |
gastric mucin was separated into soluble ( washout ) and insoluble ( adherent ) phases before colorimetric quantitation of total mucin , protein-bound hexose , and sialic acid . | NA | {
"id": "C0017135",
"name": "gastric mucin",
"pos": [
0,
13
]
} | {
"id": "C0026682",
"name": "mucin",
"pos": [
129,
134
]
} |
to determine whether cyclic adenosine monophosphate influences active potassium transport in the rat colon , we studied the effect of dibutyryl cyclic adenosine monophosphate and theophylline on unidirectional transmural 42k fluxes across proximal colonic mucosa under short-circuited conditions . | NA | {
"id": "C0001455",
"name": "cyclic adenosine monophosphate",
"pos": [
21,
51
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic adenosine",
"pos": [
134,
160
]
} |
the gall stones found in 356 of the 387 patients at operation were analysed chemically for cholesterol and calcium , physically for number , size , and mass , and radiologically before cholecystectomy for stone lucency . | NA | {
"id": "C0008350",
"name": "gall stones",
"pos": [
4,
15
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
205,
210
]
} |
out of the 406 gall-stone patients , 77 ( 19 % ) had functioning gall bladders which contained radiolucent stones 1.5 cm or less in diameter , thereby fulfilling the criteria which are used by most clinicians in selecting patients for dissolution therapy of cholesterol gall stones . | NA | {
"id": "C0008350",
"name": "gall-stone",
"pos": [
15,
25
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
275,
281
]
} |
leukotriene d4 ( ltd4 ) , the most active spasmogenic leukotriene constituent of the slow reacting substance of anaphylaxis was converted by suspended human polymorphonuclear leucocytes ( pmns ) to a single , less polar metabolite which was not further catabolized . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
0,
14
]
} | {
"id": "C0038091",
"name": "of",
"pos": [
109,
111
]
} |
leukotriene d4 ( ltd4 ) , the most active spasmogenic leukotriene constituent of the slow reacting substance of anaphylaxis was converted by suspended human polymorphonuclear leucocytes ( pmns ) to a single , less polar metabolite which was not further catabolized . | NA | {
"id": "C0023545",
"name": "leukotriene",
"pos": [
0,
11
]
} | {
"id": "C0038091",
"name": "of",
"pos": [
109,
111
]
} |
none of the other immunoglobulin isotypes underwent comparable changes in concentration nor could they be correlated with the pattern of appearance of host-protective antibodies in the sera of donor mice . | NA | {
"id": "C0021017",
"name": "immunoglobulin isotypes",
"pos": [
18,
41
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
167,
177
]
} |
urinary excretion of prostaglandin e2 ( pge2 ) and f2 alpha ( pgf2 alpha ) , plasma concentrations of renin , aldosterone , norepinephrine ( ne ) and epinephrine ( e ) were determined during pregnancy , 5 days , 3 , and 6 months after delivery in preeclampsia , normotensive pregnant , and nonpregnant control subjects . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
124,
138
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
150,
161
]
} |
the likelihood that a study was positive with respect to norepinephrine was independent of the likelihood with respect to epinephrine , so that total catecholamine values , or else the sum of norepinephrine plus epinephrine , differentiated hypertensives from normotensives to a greater extent than levels of either subs... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
57,
71
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
212,
223
]
} |
the addition of various metabolic inhibitors ( uncouplers , cyanide , arsenate , ionophores ) separately or together ( for example , arsenate and an uncoupler ) or even harsher methods of energy depletion did not prevent bacteriophage t5 from injecting its first-step-transfer dna ( a dna segment 3 micron long ) into th... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
277,
280
]
} | {
"id": "C0000702",
"name": "a dna",
"pos": [
283,
288
]
} |
transformation of single-stranded fbb101 dna was inhibited by competing double-stranded dna and vice versa , indicating that single-stranded dna interacts with the pneumococcus via the same binding site as used by double-stranded dna . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
18,
33
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
214,
233
]
} |
adenine did not affect the level of folylpolyglutamate synthetase in either organism but caused a large increase in the proportion of intracellular folates containing one-carbon units at the oxidation level of formate , folates which are substrates for enzymes involved in purine biosynthesis . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
0,
7
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
273,
279
]
} |
the folates with shorter glutamate chain lengths in bacteria cultured in the presence of adenine resulted from primary regulation of the de novo purine biosynthetic pathway , regulation which caused an accumulation of formyltetrahydropteroyl-poly-gamma-glutamates ( folate derivatives that are ineffective substrates for... | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
89,
96
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
145,
151
]
} |
pulse-labeling of protein throughout the adaptation period and comparison with a steady-state prelabel culture revealed that synthesis of two of the three light-harvesting proteins , as well as two additional high-molecular-weight photosynthetic membrane proteins , was derepressed three- to fivefold compared with bulk ... | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
125,
134
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
329,
336
]
} |
purified antibody was shown to be directed against enzyme by removal of enzyme activity in immune complexes precipitated by rabbit anti-chicken igy . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
9,
17
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
91,
107
]
} |
the increase in trans-sulfate increased 4-acetamido-4'-isothiocyano-2,2'-stilbene disulfonate affinity at the outer surface by about 4-fold under conditions where outside anion concentration was constant . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
22,
29
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
171,
176
]
} |
the protein sequence predicted by the cdna shows mouse pomc to consist of 235 amino acids with seven potential tryptic cleavage sites consisting of pairs of basic amino acid residues . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
78,
89
]
} | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
157,
173
]
} |
fibroblasts exposed to choleragen also showed evidence of persistent toxin on the surface based on the ability of the cells to bind antitoxin , antisubunit a or antisubunit b antibodies followed by 3h-protein a . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
0,
11
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
118,
123
]
} |
we conclude that these proteins arise from pyruvate-free precursor proteins by similar mechanisms and probably have diverged from a common ancestral protein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
23,
31
]
} | {
"id": "C0033665",
"name": "precursor proteins",
"pos": [
57,
75
]
} |
the reorientation and conformational changes of the pyridoxal-p ring which take place during the formation of enzyme-substrate complexes do not appear to change the environment of the phosphate moiety of the coenzyme . | NA | {
"id": "C0034266",
"name": "pyridoxal-p",
"pos": [
52,
63
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
208,
216
]
} |
the two single-stranded circular dna products formed as leading strands in rf leads to ss ( c ) reaction mixtures containing g27-4 rf i dna differed in their ability to support lagging strand dna synthesis . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
8,
23
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
192,
195
]
} |
dexamethasone regulation of alpha 1-acid glycoprotein and other acute phase reactants in rat liver and hepatoma cells . | NA | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
28,
53
]
} | {
"id": "C0001347",
"name": "acute phase",
"pos": [
64,
75
]
} |
all the post-transcriptional modifications found in 5.8 s rrna were also found in 8 s rna ; | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
58,
62
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
86,
89
]
} |
this membrane-bound complex of factor va and factor xa plus calcium constitutes the enzymatic complex prothrombinase , which effects the conversion of prothrombin to the clotting enzyme , thrombin . | NA | {
"id": "C0015520",
"name": "factor xa",
"pos": [
45,
54
]
} | {
"id": "C0015518",
"name": "prothrombinase",
"pos": [
102,
116
]
} |
by contrast , adding pa only to the co-culture of con a-stimulated cells with fresh pbm had a less marked effect on suppressor cell function . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
67,
72
]
} | {
"id": "C1321301",
"name": "pbm",
"pos": [
84,
87
]
} |
2 wk after selective perfusion of left kidneys with pan ( n = 8 rats ) or isotonic saline ( control , n = 7 rats ) , increases in albumin excretion and decreases in sodium excretion were demonstrated in pan-perfused but not in nonperfused kidneys of pan-treated rats although systemic plasma protein concentration remain... | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
130,
137
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
292,
299
]
} |
dihydroergotoxine mesylate in sublingual tablets , 3 mg daily , and in oral tablets , 6 mg daily , respectively , was given for 12 weeks , and therapeutic effects at those doses were compared by a double-blind method . | NA | {
"id": "C0991582",
"name": "sublingual",
"pos": [
30,
40
]
} | {
"id": "C0993159",
"name": "oral tablets",
"pos": [
71,
83
]
} |
by use of monoclonal antibodies and flow cytometry techniques , peripheral blood mononuclear cells from young ( 20-30 years ) and elderly ( 70+ years ) subjects were analyzed before and after culture with pokeweed mitogen to gain insight into the cellular interactions responsible for the decreased b cell response obser... | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
64,
80
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
247,
255
]
} |
the esr intensity of ascorbate radical , the concentrations of total ascorbic acid and oxidized form of ascorbic acid were determined on sera of 200 healthy individuals whose ages ranged from 12 to 96 years . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
69,
82
]
} | {
"id": "C0011177",
"name": "oxidized",
"pos": [
87,
95
]
} |
when these antigens were used to assess helper activity in lewis rats immunized with aba-tyr , it was found that an increase in the aba-epitope density and an increase in the peptide spacer size both increased the efficacy of the antigen in eliciting aba-specific help , manifest by an enhancement of anti-tnp pfc . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
136,
143
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
230,
237
]
} |
utilizing a monoclonal antibody ( mac-120 ) specific for 40 to 60 % of peripheral blood adherent mononuclear cells ( m phi ) , we were able to separate m phi into two populations based on their reactivity with the antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
12,
31
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
214,
222
]
} |
nine antigens were identified as important allergens , including the previously isolated components , age , agk , and ra6 . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
5,
13
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
43,
52
]
} |
tnp-lipopolysaccharide , tnp-brucella abortus , and dnp-liposomes containing lipid a were chosen as examples of ti type 1 antigens . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
4,
22
]
} | {
"id": "C0023767",
"name": "lipid",
"pos": [
77,
82
]
} |
a subspecies of human csf , csf-alpha , with eosinophil and granulocyte-macrophage ( gm ) colony-stimulating activity enhanced both eosinophil and neutrophil killing . | NA | {
"id": "C0009392",
"name": "csf",
"pos": [
22,
25
]
} | {
"id": "C0021757",
"name": "csf-alpha",
"pos": [
28,
37
]
} |
our data suggest that the capacity of human monocytes to synthesize csa in response to endotoxin rapidly becomes blunted after initial exposure of the cells to the lipopolysaccharide , but that the refractory state of these cells can be overcome by increasing the concentration of endotoxin . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
164,
182
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
281,
290
]
} |
reminiscent of high concentrations of formylated chemotactic peptides , another group of bacteria-derived products , the lipopolysaccharides and lipid a , stimulate pmn adherence to petri dishes . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
121,
140
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
145,
152
]
} |
replacement of gtp by its nonhydrolyzable analogue gpp ( nh ) p resulted in a persistent hormone-independent activation of ac , and addition of hormones enhanced this level of activation . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
15,
18
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
51,
63
]
} |
serum amyloid p-component ( sap ) is an acute-phase reactant of mice that occurs at baseline concentrations that vary over a 10-fold range among several common inbred mouse strains . | NA | {
"id": "C0002721",
"name": "serum amyloid p-component",
"pos": [
0,
25
]
} | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
40,
60
]
} |
the results showed that multilayered , more differentiated cultures accumulated the greatest amount of keratin , keratohyaline granule , and cell envelope proteins , although there was no apparent increase in the synthesis of these proteins in the more differentiated cultures . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
155,
163
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
213,
222
]
} |
the ebdr fibroblasts have an altered cellular shape , when compared to normal cells , in that the ebdr cells fail to flatten out and elongate , but do attach to collagen fibers like normal fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
78,
83
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
189,
200
]
} |
in this investigation the short-term excess of serum lipoproteins and the lipolytic activities in healthy volunteers were studied after single and prolonged ethanol ingestion followed by an intravenous lipid load . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
53,
65
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
202,
207
]
} |
to detect a strong cytotoxic t lymphocyte ( ctl ) response to minor histocompatibility ( h ) antigens in a 5-d mixed lymphocyte culture , it is necessary to use a responder that has been primed in vivo with antigen-bearing cells . | NA | {
"id": "C0003333",
"name": "h",
"pos": [
35,
36
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
207,
214
]
} |
the concomitant generation of 23 ng of ltc4/10 ( 6 ) sensitized bone marrow-derived mast cells represents the first example of ige-dependent release of substantial amounts of ltc4 , a component of slow reacting substance of anaphylaxis , from a mast cell population of greater than 95 % purity . | NA | {
"id": "C0023542",
"name": "ltc4",
"pos": [
39,
43
]
} | {
"id": "C0038091",
"name": "of",
"pos": [
266,
268
]
} |
an anti-idiotypic antiserum was raised in rabbits to a monoclonal antibody ( fd-1 ) with specificity for one ( the n epitope ) of the two antigenic epitopes found on the ferredoxin ( fd ) molecule . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
138,
147
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
148,
156
]
} |
treatment of mice with the fd-1 monoclonal antibody ( which should react with anti-idiotypic cells ) had an analogous effect to that of the anti-idiotype , in that mice so treated produced higher concentrations of anti-fd antibodies when they were immunized and these antibodies exhibited net increases to both determina... | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
32,
51
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
268,
278
]
} |
members of one class of variant clones appear to express cell surface hla-a2 molecules that display reduced reactivity with the selecting antibody , but normal or near normal reactivities with some other hla-a2-specific monoclonal antibodies and human alloantisera . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
138,
146
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
220,
241
]
} |
thus , a human t-t cell hybridoma that has bcgf activity in the absence of any demonstrable il-2 activity has been developed . | NA | {
"id": "C0021759",
"name": "bcgf",
"pos": [
43,
47
]
} | {
"id": "C0021764",
"name": "il-2",
"pos": [
92,
96
]
} |
the purpose of this study was to determine if the tthy-bearing cell is a precursor for cells in the periphery expressing tind and tsu . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
63,
67
]
} | {
"id": "C0018956",
"name": "precursor",
"pos": [
73,
82
]
} |
in previous studies of cns membrane proteins using two-dimensional gel electrophoretic analysis , five proteins ( mol . wt . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
27,
44
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
103,
111
]
} |
of the five common membrane proteins previously identified , only 68k 5.6 protein was synthesized by the free polysome population . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
19,
36
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
74,
81
]
} |
evoked release of endogenous amino acids was investigated in addition to more detailed studies on the stimulated efflux of preloaded [ 14c ] gaba and d- [ 3h ] aspartate ( a metabolically more stable anologue of acidic amino acids ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
29,
40
]
} | {
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
212,
230
]
} |
further , changes in adenosine concentration , without a concomitant change in l-homocysteine availability , are unlikely to lead to a significant accumulation of s-adenosylhomocysteine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
21,
30
]
} | {
"id": "C0036001",
"name": "lead",
"pos": [
125,
129
]
} |
to study the metabolism of ethanolamine glycerophospholipids , the cells were incubated with 1- [ 1-3h ] alkyl-sn-glycero-3-phosphoethanolamine ( 1-alkyl-gpe ) , for 1-20 h . | NA | {
"id": "C0162448",
"name": "glycerophospholipids",
"pos": [
40,
60
]
} | {
"id": "C0031618",
"name": "phosphoethanolamine",
"pos": [
124,
143
]
} |
a clear interface dividing subdural hematoma into an upper hypodense and a lower hyperdense part was seen on computerized tomography ( ct ) scan in seven of 140 patients with chronic subdural hematoma . | NA | {
"id": "C0018946",
"name": "subdural hematoma",
"pos": [
27,
44
]
} | {
"id": "C0749095",
"name": "chronic subdural hematoma",
"pos": [
175,
200
]
} |
a single systemic injection of endotoxin ( lipopolysaccharide or lps ) reproducibly induces a cellular infiltrate in the uveal tract of the rat eye within 24 hr . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
31,
40
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
65,
68
]
} |
no child developed epilepsy , and results in all children with brief seizures were normal on neurologic and cognitive examination at 7 years of age . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
19,
27
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
69,
77
]
} |
the tail-flick response was measured 10 or 20 min after the injection of dadl or beta-ep , respectively , after which the rats were immersed for 5 min in ice water and the number of shakes was counted . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
154,
157
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
158,
163
]
} |
ethylketocyclazocine , ketocyclazocine , levallorphan and skf 10,047 engendered stimulus control of behavior that was unambiguously cyclazocine-like . | NA | {
"id": "C0079314",
"name": "ethylketocyclazocine",
"pos": [
0,
20
]
} | {
"id": "C0010526",
"name": "cyclazocine",
"pos": [
132,
143
]
} |
the unpredictability of massive hemoptysis is underscored by eight deaths from sudden , engulfing hemorrhage in seemingly stable patients awaiting endoscopy or operation . | NA | {
"id": "C0019079",
"name": "hemoptysis",
"pos": [
32,
42
]
} | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
98,
108
]
} |
to investigate the status of the sodium-potassium pump in cells of human subjects with abnormal thyroid function , we measured the number of pump units as well as the cation transport activity of the pump in erythrocytes from 23 hyperthyroid and 7 hypothyroid patients . | NA | {
"id": "C0040128",
"name": "abnormal thyroid",
"pos": [
87,
103
]
} | {
"id": "C0020550",
"name": "hyperthyroid",
"pos": [
229,
241
]
} |
to investigate the status of the sodium-potassium pump in cells of human subjects with abnormal thyroid function , we measured the number of pump units as well as the cation transport activity of the pump in erythrocytes from 23 hyperthyroid and 7 hypothyroid patients . | NA | {
"id": "C0040128",
"name": "abnormal thyroid",
"pos": [
87,
103
]
} | {
"id": "C0020676",
"name": "hypothyroid",
"pos": [
248,
259
]
} |
fasting blood samples were drawn on days 8 , 9 , and 10 of each dietary period and analyzed for glucose , insulin , cholesterol , triglyceride ( tg ) and high density lipoprotein ( hdl ) -cholesterol concentrations . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
116,
127
]
} | {
"id": "C0023822",
"name": "high density",
"pos": [
154,
166
]
} |
following glucose ingestion , alanine rose markedly in gsd-iii , which differed from normal subjects in whom no change occurred , and from gsd-i patients in whom a sharp fall was observed . | NA | {
"id": "C0017922",
"name": "gsd-iii",
"pos": [
55,
62
]
} | {
"id": "C0017919",
"name": "gsd-i",
"pos": [
139,
144
]
} |
following beef ingestion , the direction of change of alanine was similar in the three groups , but the circulating levels in gsd-iii were significantly less than those observed in gsd-i and normal controls . | NA | {
"id": "C0017922",
"name": "gsd-iii",
"pos": [
126,
133
]
} | {
"id": "C0017919",
"name": "gsd-i",
"pos": [
181,
186
]
} |
the possibility that gluconeogenesis is enhanced in gsd-iii was supported by the prompt rise in blood glucose observed following beef ingestion , which differed from gsd-i and normal subjects , in which no rise in glucose was observed . | NA | {
"id": "C0017922",
"name": "gsd-iii",
"pos": [
52,
59
]
} | {
"id": "C0017919",
"name": "gsd-i",
"pos": [
166,
171
]
} |
the possibility that gluconeogenesis is enhanced in gsd-iii was supported by the prompt rise in blood glucose observed following beef ingestion , which differed from gsd-i and normal subjects , in which no rise in glucose was observed . | NA | {
"id": "C0005802",
"name": "blood",
"pos": [
96,
101
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
214,
221
]
} |
one had brachial plexus neuropathy ( neuralgic amyotrophy ) , and the other developed the clinical picture of myelitis . | NA | {
"id": "C0700251",
"name": "brachial plexus neuropathy",
"pos": [
8,
34
]
} | {
"id": "C0221759",
"name": "neuralgic amyotrophy",
"pos": [
37,
57
]
} |
the syndrome ranges from a potentially fatal disease characterized by hypotension and failure in multiple organ systems to a less severe condition commonly misdiagnosed as a nonspecific viral illness or gastroenteritis . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
4,
12
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
45,
52
]
} |
ketoconazole , an oral , broad-spectrum antifungal agent with relatively low toxicity , is the preferred drug for treatment of chronic mucocutaneous candidiasis and an alternative choice for treatment of thrush , vaginitis , histoplasmosis , and coccidioidomycosis . | NA | {
"id": "C0006845",
"name": "chronic mucocutaneous",
"pos": [
127,
148
]
} | {
"id": "C0006840",
"name": "thrush",
"pos": [
204,
210
]
} |
ultrasound is the modality of choice for the diagnosis of cholelithiasis and for the evaluation of the intra- and extrahepatic biliary tree in the patient with jaundice , but its role in the diagnosis of choledocholithiasis is less certain . | NA | {
"id": "C0008350",
"name": "cholelithiasis",
"pos": [
58,
72
]
} | {
"id": "C0701818",
"name": "choledocholithiasis",
"pos": [
204,
223
]
} |
dynorphin , an opioid peptide whose functions are unknown , is found in brain , pituitary , and peripheral organs . | NA | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
0,
9
]
} | {
"id": "C0205753",
"name": "opioid peptide",
"pos": [
15,
29
]
} |
these findings suggest that there may be a functional interrelationship of crf with dynorphin-related opioid peptides and provide further evidence that neurons may contain more than one bioactive substance . | NA | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
84,
93
]
} | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
102,
117
]
} |
pg was absent without associated respiratory distress syndrome ( rds ) in 17 cases ( 12 % ) and present in 123 , 3 of the infants born to these patients developed slight hyaline membrane disease . | NA | {
"id": "C0035220",
"name": "respiratory distress syndrome",
"pos": [
33,
62
]
} | {
"id": "C0020192",
"name": "hyaline membrane",
"pos": [
170,
186
]
} |
multiple coronary vasospasm : a cause of repeated myocardial infarction and symptomatic 'torsade de pointes ' ( atypical ventricular tachycardia ) . | NA | {
"id": "C0040479",
"name": "torsade de pointes",
"pos": [
89,
107
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
121,
144
]
} |
quite dramatic episodes of associated arrhythmias , specifically 'torsade de pointes ' ( atypical ventricular tachycardia ) and syncope were experienced by the patient , despite the use of numerous anti-arrhythmic and anti-anginal agents . | NA | {
"id": "C0040479",
"name": "torsade de pointes",
"pos": [
66,
84
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
98,
121
]
} |
in the present study the effects of the long-term second-line drugs d-penicillamine and oral gold ( auranofin ) on bone density are presented . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
93,
97
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
100,
109
]
} |
a major infection was diagnosed when the patient had a fever , required antibiotics , or had a prolonged hospital stay because of the wound infection . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
8,
17
]
} | {
"id": "C0043241",
"name": "wound",
"pos": [
134,
139
]
} |
influence of tachycardia cycle length and antiarrhythmic drugs on pacing termination and acceleration of ventricular tachycardia . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
13,
24
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
105,
128
]
} |
in patients with relatively slow ventricular tachycardia ( vt cycle length greater than or equal to 350 msec ) pacing terminated 37 of 44 ( 84 % ) episodes but terminated only 24 of 45 ( 51 % ) episodes of more rapid vt ( vt cycle length less than or equal to 349 msec , p less than 0.005 ) . | NA | {
"id": "C0078888",
"name": "slow ventricular tachycardia",
"pos": [
28,
56
]
} | {
"id": "C0042514",
"name": "vt",
"pos": [
222,
224
]
} |
a reentry tachycardia with anterograde conduction over the nodoventricular fiber could mimic vt as diagnosed by the usual criteria ; | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
10,
21
]
} | {
"id": "C0042514",
"name": "vt",
"pos": [
93,
95
]
} |
with treatment aimed at the underlying heart disease ( plus empiric antiarrhythmic therapy in 2 patients ) , the 11 patients who had no inducible vt have had no recurrence of symptomatic vt or cardiac arrest over a follow-up period of 19 +/- 9 months ( mean +/- standard deviation ) . | NA | {
"id": "C0018799",
"name": "heart disease",
"pos": [
39,
52
]
} | {
"id": "C0018790",
"name": "cardiac arrest",
"pos": [
193,
207
]
} |
in survivors of a cardiac arrest , the chief value of electrophysiologic testing is in identifying patients without inducible vt , who appear to have a low risk of recurrent sudden death with treatment directed at the underlying heart disease . | NA | {
"id": "C0018790",
"name": "cardiac arrest",
"pos": [
18,
32
]
} | {
"id": "C0018799",
"name": "heart disease",
"pos": [
229,
242
]
} |
effects of a parenteral nutrition regimen containing dicarboxylic amino acids on plasma , erythrocyte , and urinary amino acid concentrations of young infants . | NA | {
"id": "C0002524",
"name": "dicarboxylic amino acids",
"pos": [
53,
77
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
116,
126
]
} |
a solidphase antibody binds the acid phosphatase molecule and a second monoclonal antibody to a different antigenic site serves as the 125i-radiolabel . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
13,
21
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
71,
90
]
} |
children with epilepsy and prior febrile convulsions were similar in some respects ( sex ratio , positive family history for seizures ) to children with pure febrile convulsions and in most respects ( type of epilepsy , mental status , initial eeg , and two- and four-year remission rates in the long-term outcome ) to e... | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
125,
133
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
209,
217
]
} |
children with epilepsy and prior febrile convulsions were similar in some respects ( sex ratio , positive family history for seizures ) to children with pure febrile convulsions and in most respects ( type of epilepsy , mental status , initial eeg , and two- and four-year remission rates in the long-term outcome ) to e... | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
14,
22
]
} | {
"id": "C0009952",
"name": "febrile convulsions",
"pos": [
352,
371
]
} |
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