text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these studies provide further supporting biochemical evidence for the concept that na+ , k+-atpase resides on different membrane domains than does mg++-atpase and alkaline phosphatase and further characterizes a vesiculated membrane preparation highly enriched in putative `` '' canalicular '' '' enzyme markers . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
83,
85
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
152,
158
]
} |
liver free proline and the incorporation of labeled proline into protein-bound hydroxyproline by liver slices were not altered after 40 to 48 months of ethanol feeding . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
11,
18
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
79,
93
]
} |
in comparative studies , cellular protein and release of 51chromium ( 51cr ) were measured after addition of test compounds to cultures of fibroblasts derived from pancreatic tissue . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
25,
33
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
139,
150
]
} |
both sets of results showed that igm bearing cells were derived from a rapidly dividing precursor cell pool , by a process which takes more than 24 hr and does not require dna synthesis . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
45,
50
]
} | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
88,
102
]
} |
however , although the presence of sigd was necessary for the response of sigd positive cells to thymus-dependent antigens , the presence of this isotype was not obligatory for the response of the sigd positive population to thymus independent antigens . | NA | {
"id": "C0020843",
"name": "sigd",
"pos": [
35,
39
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
146,
153
]
} |
thyroglobulin anti-thyroglobulin immune complexes with human antibodies from four patient sera were performed in a wide range of antigen : antibody ratios and run in 5 % -40 % sucrose gradients . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
33,
49
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
139,
147
]
} |
at various times after infection , spleen cells were tested for their capacity to proliferate in vitro in response to concanavalin a ( cona ) and to allogeneic cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
42,
47
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
149,
165
]
} |
thus , il2 production by infected-mouse spleen cells was shown to decline earlier than their proliferative responses to cona and to allogeneic cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
47,
52
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
132,
148
]
} |
immunization of rats with the synthetic toxin coupled to a large-molecular-weight carrier raised serum and mucosal antitoxin responses which provided protection against challenge with either the synthetic or biological toxin as well as with viable heat-stable enterotoxin-in-producing organisms . | NA | {
"id": "C0040549",
"name": "biological toxin",
"pos": [
208,
224
]
} | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
260,
271
]
} |
analyses with amino acids and amino sugars of the cell wall fractions and peptidoglycan specimens revealed that d-glutamic acid , d-alanine , l-alanine , meso-2,6-diaminopimelic acid ( a2pm ) , muramic acid , and glucosamine were the principal components . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
14,
25
]
} | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
142,
151
]
} |
cryopreserved blood mononuclear cells from the acute phase of varicella could suppress the phytohemagglutinin response of autologous convalescent-phase cells . | NA | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
14,
37
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
87,
90
]
} |
from hapten inhibition of precipitation by peg of mw 300 it appears that the antigenic determinant of peg may be a sequence of 6-7 -ch2ch2o-units . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
5,
11
]
} | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
77,
98
]
} |
from hapten inhibition of precipitation by peg of mw 300 it appears that the antigenic determinant of peg may be a sequence of 6-7 -ch2ch2o-units . | NA | {
"id": "C0032477",
"name": "peg",
"pos": [
43,
46
]
} | {
"id": "C0032483",
"name": "peg",
"pos": [
102,
105
]
} |
growth of the strain for as short a period as 10 min at 42 degrees c resulted in a 40 to 60 % loss of rna synthetic capacity and a fourfold decrease in percent rrna synthesized in toluenized cell preparations . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
102,
105
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
160,
164
]
} |
experiments using protoplasts demonstrated that the effect of catabolite repression on this pathway was reversible by 1.2 mm camp but not by other nucleotides and cyclic nucleotides . | NA | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
147,
158
]
} | {
"id": "C0028631",
"name": "cyclic nucleotides",
"pos": [
163,
181
]
} |
a similar temperature dependence for the lipoprotein resonances suggested that solid and liquid species are co-mixed in individual lipoprotein particles within a purified subfraction . | NA | {
"id": "C0065058",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
131,
142
]
} |
methods were developed to efficiently adsorb both these synthetic glycolipids and natural glycosphingolipids ( including gangliosides ) from aqueous ethanol solution onto plastic wells . | NA | {
"id": "C0017950",
"name": "glycolipids",
"pos": [
66,
77
]
} | {
"id": "C0017978",
"name": "glycosphingolipids",
"pos": [
90,
108
]
} |
no adhesion above background levels ( 10-25 % ) was observed to surfaces adsorbed with other synthetic glycolipids including glucosyl , galactosyl , mannosyl , or lactosyl 3-deoxyceramide , 3-deoxyceramide , or to the naturally occurring glycosphingolipids , lactosyl ceramide or ganglioside gm1 . | NA | {
"id": "C0017950",
"name": "glycolipids",
"pos": [
103,
114
]
} | {
"id": "C0017978",
"name": "glycosphingolipids",
"pos": [
238,
256
]
} |
since methylation of acidic residues on erythrocyte membrane proteins has been detected exclusively on d-aspartic acid residues ( mcfadden , p. n. , and clarke , s. ( 1982 ) proc . natl . acad . sci . u. s. a . 79 , 2460-2464 ) , these results are consistent with an accumulation of d-aspartic acid in membrane protein d... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
61,
69
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
302,
318
]
} |
alterations seen in vivo following withdrawal of insulin included changes in the relative concentrations of several plasma proteins , a 40 % reduction in total liver rna relative to dna , a 5-fold reduction in albumin synthesis relative to the synthesis of total liver proteins , a 5-fold reduction in albumin mrna relat... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
123,
131
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
244,
253
]
} |
alterations seen in vivo following withdrawal of insulin included changes in the relative concentrations of several plasma proteins , a 40 % reduction in total liver rna relative to dna , a 5-fold reduction in albumin synthesis relative to the synthesis of total liver proteins , a 5-fold reduction in albumin mrna relat... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
123,
131
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
430,
437
]
} |
thus , the structurally similar aminoacid neurotransmitters aspartate and gamma-aminobutyric acid , as well as other neurotransmitters such as dopamine , norepinephrine , serotonin , acetylcholine , and glycine , failed to show a significant atp-dependent uptake into these vesicles . | NA | {
"id": "C0002520",
"name": "aminoacid",
"pos": [
32,
41
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
203,
210
]
} |
and partial conversion of bound adenosine to a substance liberating adenine has been demonstrated under conditions of enzymatic synthesis and hydrolysis of adohcy ( ueland , p. m. , and helland , s. ( 1980 ) j. biol . chem . 255 , 7722-7727 ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
32,
41
]
} | {
"id": "C0036001",
"name": "adohcy",
"pos": [
156,
162
]
} |
exposure of the hepatocytes to compounds which block the formation of the adenosine-adohcy hydrolase complex ( ara-a , 3-deazaadenosine , and homocysteine ) for 1 to 2.5 h only slightly reduced the amount of adenosine associated with the enzyme , indicating a slow turnover of the complex under the conditions of the exp... | NA | {
"id": "C0042646",
"name": "ara-a",
"pos": [
111,
116
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
208,
217
]
} |
thus , tubulin-gdp nucleotide exchange is rapid , so that added radioactive guanine nucleotides can be used in studies of relatively rapid reactions involving the tubulin subunit . | NA | {
"id": "C0018340",
"name": "gdp",
"pos": [
15,
18
]
} | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
76,
95
]
} |
the binding of c1q to heparin was quantitatively examined by utilizing an assay that employs a 125i-labeled low molecular weight heparin glycosaminoglycan ( lmw-hep ) ( mr = 8500 ) . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
22,
29
]
} | {
"id": "C0019139",
"name": "low",
"pos": [
108,
111
]
} |
the binding of c1q to heparin was quantitatively examined by utilizing an assay that employs a 125i-labeled low molecular weight heparin glycosaminoglycan ( lmw-hep ) ( mr = 8500 ) . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
22,
29
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
137,
154
]
} |
a variety of mucopolysaccharides were able to inhibit interaction of c1q with 125i-lmw-hep , the most effective being heparan sulfate and dermatan sulfate . | NA | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
13,
32
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
118,
133
]
} |
specific binding of purified proteins from the large ribosomal subunits of saccharomyces cerevisiae to 5.8 s rrna was examined by three different methods : nitrocellulose membrane filtration , sucrose density gradient centrifugation , and rna-sepharose column chromatography . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
109,
113
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
239,
242
]
} |
the chemical structure of an equine hematoside , which contained an ester group and comprised 72 % of the total erythrocyte gangliosides , was determined by means of nondestructive and destructive procedures . | NA | {
"id": "C0016897",
"name": "hematoside",
"pos": [
36,
46
]
} | {
"id": "C0017082",
"name": "gangliosides",
"pos": [
124,
136
]
} |
a 400-mhz nuclear magnetic resonance spectrum of the ganglioside in perdeuterodimethyl sulfoxide demonstrated three protons due to a methyl group of an acetyl moiety , as well as amide and anomeric protons which were compatible with those of the ordinary hematoside . | NA | {
"id": "C0017082",
"name": "ganglioside",
"pos": [
53,
64
]
} | {
"id": "C0016897",
"name": "hematoside",
"pos": [
255,
265
]
} |
in contrast to ordinary hematoside , which reacted strongly with hanganutziu-deicher ( h-d ) antibodies of a heterophile type in human , this ganglioside did not exhibit any h-d antigenicity . | NA | {
"id": "C0016897",
"name": "hematoside",
"pos": [
24,
34
]
} | {
"id": "C0017082",
"name": "ganglioside",
"pos": [
142,
153
]
} |
this effect was specific for guanine nucleotides , being weaker for other nucleotides triphosphate and gdp , and absent for cyclic gmp and gmp . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
29,
48
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
103,
106
]
} |
this effect was specific for guanine nucleotides , being weaker for other nucleotides triphosphate and gdp , and absent for cyclic gmp and gmp . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
29,
48
]
} | {
"id": "C0018338",
"name": "cyclic gmp",
"pos": [
124,
134
]
} |
this effect was specific for guanine nucleotides , being weaker for other nucleotides triphosphate and gdp , and absent for cyclic gmp and gmp . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
29,
48
]
} | {
"id": "C0018346",
"name": "gmp",
"pos": [
139,
142
]
} |
materials containing significant amounts of the phosphoamino acids were subsequently chromatographed on cm-cellulose at ph 4.65 , and the analyses for phosphoserine and phosphothreonine were repeated . | NA | {
"id": "C0524823",
"name": "phosphoamino",
"pos": [
48,
60
]
} | {
"id": "C0031721",
"name": "phosphoserine",
"pos": [
151,
164
]
} |
materials containing significant amounts of the phosphoamino acids were subsequently chromatographed on cm-cellulose at ph 4.65 , and the analyses for phosphoserine and phosphothreonine were repeated . | NA | {
"id": "C0524823",
"name": "phosphoamino",
"pos": [
48,
60
]
} | {
"id": "C0031724",
"name": "phosphothreonine",
"pos": [
169,
185
]
} |
the protein isolates showed a main band migrating slightly faster than albumin in gel electrophoresis under nondenaturing conditions . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
71,
78
]
} |
each component was purified and the specific activities in [ 3h ] proline , [ 3h ] hydroxyproline , [ 3h ] serine , and [ 3h ] phosphoserine were determined . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
66,
73
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
83,
97
]
} |
the interaction in vitro of the intermediate filament protein vimentin with naturally occurring rnas and dnas . | NA | {
"id": "C0021769",
"name": "intermediate filament protein",
"pos": [
32,
61
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
62,
70
]
} |
the major peptide fragments of arginine-vasopressin were [ cyt6 ] -avp- ( 2-9 ) , [ cyt6 ] -avp- ( 3-9 ) , [ less than glu4 , cyt6 ] -avp- ( 4-9 ) , and a peptide having the avp- ( 4-8 ) sequence . | NA | {
"id": "C0030935",
"name": "peptide fragments",
"pos": [
10,
27
]
} | {
"id": "C0030956",
"name": "peptide",
"pos": [
155,
162
]
} |
it degrades polynucleotides of repeating base sequence as well as single-stranded dna , yielding oligonucleotides of even number , in which the main reaction products are dinucleotides . | NA | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
12,
27
]
} | {
"id": "C0028953",
"name": "oligonucleotides",
"pos": [
97,
113
]
} |
enhancement between two monoclonal antibodies directed against the same antigen is when binding of one antibody , the enhancing antibody , increases the measured binding of the other antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
24,
45
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
183,
191
]
} |
the ability of the wheat germ uracil-dna glycosylase to completely remove available uracil from synthetic dna substrates in which thymine had been replaced by uracil in varying percentages was also examined and found not to depend on percentage of uracil in the substrates . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
130,
137
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
248,
254
]
} |
the effects of retinoid addition of vitamin a-depleted ( uv-irradiated ) culture medium on uridine metabolism in cultured sertoli cells have been studied . | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
15,
23
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
36,
45
]
} |
the effects of vitamin a deprivation on uridine incorporation , as well as carbamylphosphate synthetase activity , could be completely restored to or above control values by supplementing vitamin a-depleted cell culture medium with either retinol or retinoic acid . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
15,
24
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
250,
263
]
} |
in contrast , dipeptide nucleophiles did not significantly accelerate the cathepsin b-catalyzed cleavage of either the p-nitroanilide or the 2-naphthylamide of n alpha-benzoylarginine , suggesting that the hydrolysis of these amide substrates was acylation rate-limiting . | NA | {
"id": "C0005092",
"name": "2-naphthylamide",
"pos": [
141,
156
]
} | {
"id": "C0002482",
"name": "amide",
"pos": [
226,
231
]
} |
the soluble ncps of bone fell into four categories : acidic glycoproteins , gamma-carboxyglutamate-containing proteins , phosphoproteins , and proteoglycans . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
65,
73
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
121,
136
]
} |
resonance raman spectra of deoxy and carbonmonoxy leghemoglobin ( lb ) are compared to the corresponding forms of human adult hemoglobin ( hba ) . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
53,
63
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
139,
142
]
} |
the interaction between the peptide melittin from bee venom with multilamellar liposomes of dipalmitoylphosphatidylcholine or egg yolk phosphatidylcholine has been studied by the method of temperature scanning densitometry , yielding information on the specific volume of the association products and on the changes duri... | NA | {
"id": "C0000039",
"name": "dipalmitoylphosphatidylcholine",
"pos": [
92,
122
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
135,
154
]
} |
results which indicate that phosphate is the transported anion included ( a ) atp-dependent uptake of [ 32p ] phosphate by lysosomal membrane vesicles and ( b ) stimulation of atp-dependent acidification of these vesicles by added phosphate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
57,
62
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
231,
240
]
} |
after two precipitation steps with the solubilized membrane proteins , a protein fraction was obtained in which significantly high affinity phlorizin binding was detected . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
51,
68
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
73,
80
]
} |
initiation factors ( if ) , elongation factors ( ef ) , and a number of ribosomal proteins were identified unambiguously in gel patterns following two-dimensional polyacrylamide gel electrophoresis . | NA | {
"id": "C0030943",
"name": "initiation factors",
"pos": [
0,
18
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
72,
90
]
} |
the enzyme was characterized with respect to its ability to relax supercoiled dna and to catenate nicked circular dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
78,
81
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
105,
117
]
} |
no significant differences were seen in the affinities of the polymerases for ttp and dgtp , or for the triphosphates of 9- ( 2-hydroxyethyloxymethyl ) guanine ( acyclovir ) or ( e ) -5- ( 2-bromovinyl ) -2'-deoxyuridine ( bvdu ) ( drugs used in their isolation ) . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
152,
159
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
162,
171
]
} |
in order to generate the molecular probes needed to investigate the seemingly coordinate expression of carbonic anhydrase ( ca i ) and beta-globin within erythrocytes during human development , ca i-containing polyribosomes have been isolated from rabbit reticulocytes by reaction with purified antibodies to ca i follow... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
295,
305
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
346,
362
]
} |
carbohydrate content of the purified enzymes as determined by acid hydrolysis , reduction , and gas chromatography of the alditol acetates revealed only trace amounts of neutral and amino hexoses in each of the five isozymes . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
37,
44
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
216,
224
]
} |
the arginine at position 8 suggests that a trypsin-like cleavage may separate the nh2-terminal octapeptide from the remainder of the c-peptide during the post-translational processing of dog proinsulin in the pancreas . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
133,
142
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
191,
201
]
} |
however , the simultaneous presence of troponin-i and t2 resulted in formation of a strong troponin-i/t2/tropomyosin ternary complex at site 2 such that troponin-i/t2 complex was now eluted at 0.45 to 0.5 m nacl . | NA | {
"id": "C0077401",
"name": "troponin-i",
"pos": [
39,
49
]
} | {
"id": "C0041199",
"name": "troponin",
"pos": [
153,
161
]
} |
rapid transfer of reca protein to single-stranded dna occurs during all stages of dna strand exchange and does not require atp . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
34,
53
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
82,
85
]
} |
the cell/medium equilibrium distribution ratio of the lipophilic cation tetraphenylphosphonium ion ( tpp+ ) decreases in parallel fashion , suggesting that a decrease in membrane potential may be a major factor in the stepdown . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
65,
71
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
134,
137
]
} |
the culture of nil hamster fibroblasts in mem lacking nicotinamide ( nam-mem ) leads to : ( 1 ) the rapid loss of intracellular total nicotinamide adenine dinucleotide ( nad ( h ) ) content in these cells from a level of 150-200 pmoles/10 ( 5 ) cells to less than 20 pmoles/10 ( 5 ) cells ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
27,
38
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
283,
288
]
} |
nonaldosterone mineralocorticoids , such as deoxycorticosterone ( doc ) and 18-hydroxy-doc , have been reported to be elevated in some patients with primary aldosteronism ( pa ) . | NA | {
"id": "C0011710",
"name": "deoxycorticosterone",
"pos": [
44,
63
]
} | {
"id": "C0000173",
"name": "18-hydroxy-doc",
"pos": [
76,
90
]
} |
changes in da levels were compared to increases in epinephrine ( e ) and norepinephrine ( ne ) , all of which were measured by the radioenzymatic technique . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
51,
62
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
73,
87
]
} |
the value of urinary pregnanediol and plasma progesterone to indirectly monitor progesterone production were confirmed . | NA | {
"id": "C0033004",
"name": "pregnanediol",
"pos": [
21,
33
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
80,
92
]
} |
however , serum 1,25 ( oh ) 2d levels , measured in 27 women with a twin pregnancy in both the second and third trimesters as well as at delivery , did not differ from the levels observed in women with a singleton pregnancy . | NA | {
"id": "C0032981",
"name": "third trimesters",
"pos": [
106,
122
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
214,
223
]
} |
patients with paget 's disease were given salmon ct daily for a period of 3 yr , the bone mineral content ( bmc ) in the nonpagetic distal radius was measured periodically for 3 yr , and the data were compared with those of the control group of patients with paget 's disease not receiving ct treatment . | NA | {
"id": "C0073994",
"name": "salmon ct",
"pos": [
42,
51
]
} | {
"id": "C0006668",
"name": "ct",
"pos": [
290,
292
]
} |
previous studies from our laboratory have demonstrated that 25-hydroxyvitamin d3 ( 25ohd3 ) therapy is effective in raising the impaired intestinal calcium absorption ( alpha ) associated with postmenopausal osteoporosis . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
60,
80
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
83,
89
]
} |
to examine the gonadotropic milieu presiding over recruitment and selection of a dominant follicle during gonadotropin induction of ovulation , four patients were studied over nine cycles of human pituitary gonadotropin ( hpg ) therapy . | NA | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
106,
118
]
} | {
"id": "C0018066",
"name": "pituitary gonadotropin",
"pos": [
197,
219
]
} |
several previous studies have examined the response of active kallikrein excretion to alterations in sodium and water metabolism , but the response of inactive kallikrein has not been evaluated systematically . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
73,
82
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
118,
128
]
} |
we have used this technique to study the effect of alterations in sodium and water metabolism on kallikrein excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
83,
93
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
108,
117
]
} |
during the infusion of angiotensin ii , blood pressure increased and renin activity decreased appropriate in degree to the preinfusion concentration of angiotensin ii . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
23,
37
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
152,
163
]
} |
in eight patients ( six males and two females ) hospitalized for prolonged coma ( 164-1320 days ; five patients were in traumatic coma , two after cardiac arrest during surgery , and one after a venomous scorpion sting ) , diurnal variation of cortisol secretion , human ( l ) gh , prl , tsh secretion as well as the rel... | NA | {
"id": "C0009421",
"name": "coma",
"pos": [
75,
79
]
} | {
"id": "C0394016",
"name": "traumatic coma",
"pos": [
120,
134
]
} |
with normal fibroblasts the affinity and capacity of nuclear uptake of [ 3h ] 1,25 ( oh ) 2d3 were 0.5 nm and 10,300 sites per cell , respectively ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
12,
23
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
127,
131
]
} |
this might suggest that anion exchange ( cl/hco3 ) accounts for only a small fraction of total chloride absorption . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
24,
29
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
95,
103
]
} |
the effect of peritubular protein removal on the passive absorption of nacl driven by anion concentration gradients was examined in seven pct perfused with a high chloride solution simulating late proximal tubular fluid and bathed in either serum or uf at 20 degrees c . | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
71,
75
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
163,
171
]
} |
the effect of peritubular protein removal on the passive absorption of nacl driven by anion concentration gradients was examined in seven pct perfused with a high chloride solution simulating late proximal tubular fluid and bathed in either serum or uf at 20 degrees c . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
86,
91
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
163,
171
]
} |
furthermore , the addition of normal irradiated t cells to patient peripheral blood mononuclear cells led to an augmentation of igm synthesis in 15 of 17 and to increased igg synthesis in 9 of the 17 patients studied , including 9 of the 12 patients who had synthesized igg before the addition of the irradiated t cells ... | NA | {
"id": "C1321301",
"name": "peripheral",
"pos": [
67,
77
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
314,
319
]
} |
the other type is specific for z-dna and remained in the serum after removal of the cross-reactive antibody by extensive absorption on a denatured dna affinity column . | NA | {
"id": "C0043442",
"name": "z-dna",
"pos": [
31,
36
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
147,
150
]
} |
we conclude that under appropriate conditions human fibroblasts are potent sources of csa , that the production of csa by these cells is regulated by a stimulatory monokine , and that the production and or release of the monokine is inhibited by lactoferrin , a neutrophil-derived putative feedback inhibitor of granulop... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
52,
63
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
128,
133
]
} |
a purified allergen , antigen sbp , was obtained from the pollen of the japanese cedar ( cryptomeria japonica , sugi in japanese ) by ammonium sulfate precipitation , ion-exchange chromatography on diethylaminoethyl and carboxymethyl cellulose , and gel chromatography on sephadex g-150 . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
11,
19
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
22,
29
]
} |
production of monoclonal antibodies to hepatitis b surface and core antigens , and use in the detection of viral antigens in liver biopsies . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
68,
76
]
} | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
107,
121
]
} |
the use of antibody from whole serum or monoclonal antibodies to form complexes resulted in the stimulation of mouse b lymphocytes . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
11,
19
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
40,
61
]
} |
the regenerating spleen 8 days after an injection of a sublethal dose ( 300 mg/kg ) of cyclophosphamide ( cy ) had a defective capacity to give rise to cytotoxic t lymphocytes ( ctl ) in response against allogeneic cells , whereas the cytotoxicity against 2,4,6-trinitrophenyl- ( tnp ) modified syngeneic cells was at th... | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
204,
220
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
305,
310
]
} |
finally , alpha-ifn did not increase the ig production of pbmc induced by epstein barr virus ( ebv ) , and the outgrowth of ebv-infected pbmc was not affected . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
37,
40
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
137,
141
]
} |
this fibroblast chemotactic activity was also detected in culture supernatants of granuloma adherent cells highly enriched for macrophages ( 95 % latex-ingesting ) but not in culture supernatants from resident peritoneal macrophages of uninfected or infected mice . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
5,
15
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
101,
106
]
} |
serum antibodies reacting with liposomes containing dimyristoyl phosphatidylcholine ( dmpc ) , phosphatidylinositol ( pl ) , phosphatidylinositol phosphate ( plp ) , or cardiolipin were detected at 3 to 4 wk by complement-mediated release of trapped marker from liposomes . | NA | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
95,
115
]
} | {
"id": "C0071655",
"name": "phosphatidylinositol phosphate",
"pos": [
125,
155
]
} |
the antigenic heterogeneity of multiple lesions removed from one patient and the independent expression of the various types of maa investigated suggest that combinations of monoclonal antibodies to maa may be more effective than single antibodies for radioimaging and immunotherapy . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
174,
195
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
237,
247
]
} |
thus , pharmacologic doses of corticosteroids might produce serum hormone concentrations which could interfere with activity of host monocytes against the tissue-invasive forms of c. albicans and a. fumigatus in vivo . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
30,
45
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
66,
73
]
} |
the protection by antisera to o antigens and antigens ( lipid a , the re 595 mutant of salmonella minnesota , and the j5 mutant of escherichia coli ) of the core portion of endotoxin against lethal challenge with lipopolysaccharide ( lps ) was compared . | NA | {
"id": "C0069180",
"name": "o antigens",
"pos": [
30,
40
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
213,
231
]
} |
the protection by antisera to o antigens and antigens ( lipid a , the re 595 mutant of salmonella minnesota , and the j5 mutant of escherichia coli ) of the core portion of endotoxin against lethal challenge with lipopolysaccharide ( lps ) was compared . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
56,
63
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
213,
231
]
} |
when comparisons were made using passive transfer to similar quantities of hemagglutinating or precipitating antibody , antiserum to the re mutant was considerably more protective than o-specific antiserum . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
109,
117
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
196,
205
]
} |
hypercholesterolemia occurs during pregnancy in rats and human beings , beginning in the second trimester and increasing progressively throughout the remainder of pregnancy . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
89,
105
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
163,
172
]
} |
a two-site immunoradiometric assay for human extrinsic ( tissue-type ) plasminogen activator was developed by using rabbit antibodies raised against plasminogen activator purified from human melanoma cell culture fluid . | NA | {
"id": "C0032143",
"name": "tissue-type",
"pos": [
57,
68
]
} | {
"id": "C0032144",
"name": "plasminogen",
"pos": [
149,
160
]
} |
radioimmunoassays utilizing antisera specific for the carboxyl-terminal portion of human chorionic gonadotrophin ( hcg ) beta-subunit were used to measure the concentration in human pituitary extracts of an immunoactive hcg factor ( hcg ' ) which was different from human lh ( hlh ) . | NA | {
"id": "C0106132",
"name": "human chorionic gonadotrophin",
"pos": [
83,
112
]
} | {
"id": "C0018062",
"name": "hcg",
"pos": [
233,
236
]
} |
a circadian rhythm of 17-hydroxy-corticosteroids ( 17-oh-cs ) , 17-ketosteroids ( 17-ks ) , urinary free cortisol and 18-oh-doc was defined for each of the four seasons with stable acrophases throughout the year and the same excretory profiles . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
33,
48
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
64,
79
]
} |
as both the endogenous antigen ( gp330 ) and exogenously administered anti-gp330 antibody were localized to coated pits , it seems likely that coated pits located at the base of the foot processes are the sites where the hn antigen ( gp330 ) and circulating antibodies directed against gp330 meet and where immune comple... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
258,
268
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
307,
323
]
} |
the use of the amino acid analogues canavanine ( for arginine ) and azetidine ( for proline ) in parallel allowed experiments on the identification of proteins synthesized early and late during lytic infection . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
15,
25
]
} | {
"id": "C0006825",
"name": "canavanine",
"pos": [
36,
46
]
} |
in order to find out whether polyoma virus ( py ) integration into chromosomes causes rearrangements in the cell dna flanking the integration site , we have mapped the flanking sequences in the inducible lpt line of py-transformed rat cells and the corresponding sequences in normal rat fibroblasts , and then compared t... | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
108,
112
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
287,
298
]
} |
to carry out this study we have cloned a segment including py dna and flanking sequences in the bacteriophage vector lambda gt wes and subcloned the flanking cell dna in a bacterial plasmid . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
62,
65
]
} | {
"id": "C0012924",
"name": "dna",
"pos": [
163,
166
]
} |
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