text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
one exon ( alpha 2 ) encodes a domain of 94 amino acids with strong sequence homology both to ig constant region domains and to ig-like domains in hla-b7 , beta 2-microglobulin , and the hla-dr light chain . | NA | {
"id": "C0021008",
"name": "ig constant region",
"pos": [
94,
112
]
} | {
"id": "C0021027",
"name": "ig",
"pos": [
195,
197
]
} |
survey of the protease specificity for the activation revealed that subtilisin bpn ' and several other proteases having far broader substrate specificity than trypsin also activated the enzyme . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
14,
22
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
103,
112
]
} |
those anti-asialo gm1 reaction products observed on the surface and intracellular structures disappeared by ethanol- or methanol-treatment but mostly remained by acetone-treatment . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
108,
115
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
120,
128
]
} |
we also found that the newly discovered epsilon-crystallin ( 18 ) appears long after the three major crystallin classes . | NA | {
"id": "C0014641",
"name": "epsilon-crystallin",
"pos": [
40,
58
]
} | {
"id": "C0010422",
"name": "crystallin",
"pos": [
101,
111
]
} |
amyloid deposits in other types of diseases have been found to contain amyloid p protein ( ap ) . | NA | {
"id": "C0002716",
"name": "amyloid",
"pos": [
0,
7
]
} | {
"id": "C1456454",
"name": "amyloid",
"pos": [
71,
78
]
} |
it is suggested that the density and/or the accessibility of membranous antigens may be different on b and t cells , or alternatively that in addition to antigens common to all lymphocytes , anti-i and non-i/i cold agglutinins recognize specific antigenic determinants on b lymphocytes , whereas anti-i cold agglutinins ... | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
72,
80
]
} | {
"id": "C0003316",
"name": "antigenic",
"pos": [
339,
348
]
} |
it is valuable because of : ( 1 ) detection of all elements and isotopes from mass 1 , hydrogen ; | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
51,
59
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
87,
95
]
} |
basal mg2+-atpase , na+ , k+-atpase and ca2+ , mg2+-atp activities were inhibited in a time dependent manner by plc treatment . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
6,
9
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
29,
35
]
} |
a significant increase in hemoglobin could be detected in all the patients with serum ferritin less than 65 ng/ml and in most patients with serum ferritin less than 160 ng/ml , while hemoglobin change was negligible when serum ferritin levels in dialysis exceeded this value . | NA | {
"id": "C0019016",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
183,
193
]
} |
the delta 5 intermediates , 17-hydroxypregnenolone ( 3 beta , 17-dihydroxy-5-pregnen-20-one ) and dehydroepiandrosterone ( 3 beta-hydroxy-5-androsten-17-one ) , accounted for less than 1 % of substrate conversion , indicating a clear preference for leydig cells to metabolize ( 3h ) pregnenolone via the delta 4 pathway ... | NA | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
28,
50
]
} | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
283,
295
]
} |
three ecdysteroids conjugates with a hydroxy group at c-20 were isolated from developing eggs of locusta migratoria and identified as 22-phosphate conjugates of 2-deoxy-20-hydroxy-ecdysone , 20-hydroxyecdysone and 20-hydroxyecdysone acetate . | NA | {
"id": "C0058915",
"name": "ecdysteroids",
"pos": [
6,
18
]
} | {
"id": "C0013494",
"name": "ecdysone",
"pos": [
224,
232
]
} |
three ecdysteroids conjugates with a hydroxy group at c-20 were isolated from developing eggs of locusta migratoria and identified as 22-phosphate conjugates of 2-deoxy-20-hydroxy-ecdysone , 20-hydroxyecdysone and 20-hydroxyecdysone acetate . | NA | {
"id": "C0058915",
"name": "ecdysteroids",
"pos": [
6,
18
]
} | {
"id": "C0013495",
"name": "20-hydroxyecdysone",
"pos": [
214,
232
]
} |
using the respiration method the values of postprandial energy output were determined in rats kept on four diets , one of which was a no-residue diet and three diets contained pectins , lignin and cellulose respectively as sources of residues . | NA | {
"id": "C0023705",
"name": "lignin",
"pos": [
186,
192
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
197,
206
]
} |
on the other hand , after administration of diets containing lignin or cellulose the energy output of the animals increased in relation to the no-residue diet by 16.0 % and 12.8 % respectively ( p less than 0.05 ) . | NA | {
"id": "C0023705",
"name": "lignin",
"pos": [
61,
67
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
71,
80
]
} |
changes in gastric acid output , as well as the concentration of serum gastrin , blood glucose and serum insulin were measured in hypersecretory and normosecretory duodenal ulcer patients following 2-deoxy-d-glucose ( 2-dg ) administration . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
81,
94
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
208,
215
]
} |
circulating proteins synthetized by the liver , such as albumin and clotting factors , are frequently decreased in chronic liver disease . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
12,
20
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
56,
63
]
} |
desensitization to atp and adenosine ( and to atp + adenosine simultaneously ) did not affect the non-adrenergic inhibition in response to radial distension or transmural stimulation . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
27,
36
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
46,
49
]
} |
modification of endorphin/enkephalin analgesia and stress-induced analgesia by divalent cations , a cation chelator and an ionophore . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
79,
95
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
100,
106
]
} |
specific but noncompetitive inhibition by 2-alkylthio analogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate . | NA | {
"id": "C0001413",
"name": "adenosine",
"pos": [
67,
76
]
} | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
165,
176
]
} |
specific but noncompetitive inhibition by 2-alkylthio analogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate . | NA | {
"id": "C0001413",
"name": "adenosine",
"pos": [
67,
76
]
} | {
"id": "C0001459",
"name": "adenosine 5",
"pos": [
165,
176
]
} |
some 2-alkylthio derivatives of adenosine 5'-monophosphate ( amp ) , adenosine 5'-monophosphorothioate ( amps ) and adenosine 5'-triphosphate ( atp ) were examined as inhibitors of human platelet aggregation . | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
32,
43
]
} | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
116,
127
]
} |
some 2-alkylthio derivatives of adenosine 5'-monophosphate ( amp ) , adenosine 5'-monophosphorothioate ( amps ) and adenosine 5'-triphosphate ( atp ) were examined as inhibitors of human platelet aggregation . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
32,
41
]
} | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
116,
127
]
} |
2-methylthio-amp , 2-ethylthio-amp , 2- ( pentan-l-yl ) thio-amp , 2-ethylthio-amps , 2-methylthio-atp and 2-ethylthio-atp ( 100 microm ) each inhibited aggregation induced by adenosine 5'-diphosphate ( adp ) but not by 11 alpha , 9 alpha-epoxymethano prostaglandin h2 , a stable endoperoxide analogue . | NA | {
"id": "C0001413",
"name": "amp",
"pos": [
13,
16
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
119,
122
]
} |
2-methylthio-amp , 2-ethylthio-amp , 2- ( pentan-l-yl ) thio-amp , 2-ethylthio-amps , 2-methylthio-atp and 2-ethylthio-atp ( 100 microm ) each inhibited aggregation induced by adenosine 5'-diphosphate ( adp ) but not by 11 alpha , 9 alpha-epoxymethano prostaglandin h2 , a stable endoperoxide analogue . | NA | {
"id": "C0001413",
"name": "amp",
"pos": [
13,
16
]
} | {
"id": "C0001459",
"name": "adenosine 5",
"pos": [
176,
187
]
} |
2-methylthio-amp , 2-ethylthio-amp , 2- ( pentan-l-yl ) thio-amp , 2-ethylthio-amps , 2-methylthio-atp and 2-ethylthio-atp ( 100 microm ) each inhibited aggregation induced by adenosine 5'-diphosphate ( adp ) but not by 11 alpha , 9 alpha-epoxymethano prostaglandin h2 , a stable endoperoxide analogue . | NA | {
"id": "C0001443",
"name": "amps",
"pos": [
79,
83
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
119,
122
]
} |
the atp analogues achieved greater inhibition of aggregation induced by adp ( 5 microm ) than did the amp analogues . | NA | {
"id": "C0001480",
"name": "atp",
"pos": [
4,
7
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
102,
105
]
} |
the atp analogues achieved greater inhibition of aggregation induced by adp ( 5 microm ) than did the amp analogues . | NA | {
"id": "C0001459",
"name": "adp",
"pos": [
72,
75
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
102,
105
]
} |
these 2-alkylthio substituted analogues of amp and atp are specific but noncompetitive inhibitors of adp-induced human platelet aggregation . | NA | {
"id": "C0001413",
"name": "amp",
"pos": [
43,
46
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
51,
54
]
} |
these 2-alkylthio substituted analogues of amp and atp are specific but noncompetitive inhibitors of adp-induced human platelet aggregation . | NA | {
"id": "C0001413",
"name": "amp",
"pos": [
43,
46
]
} | {
"id": "C0001459",
"name": "adp",
"pos": [
101,
104
]
} |
binding was stereoselective with regard to the ( - ) -isomer of noradrenaline and the order of potency for displacement of [ 3h ] -guanfacine by agonists was naphazoline greater than clonidine greater than ( - ) -adrenaline greater than ( - ) -alpha methylnoradrenaline greater than ( - ) -noradrenaline greater than ( +... | NA | {
"id": "C0025805",
"name": "alpha-methylnoradrenaline",
"pos": [
326,
351
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
372,
385
]
} |
binding was stereoselective with regard to the ( - ) -isomer of noradrenaline and the order of potency for displacement of [ 3h ] -guanfacine by agonists was naphazoline greater than clonidine greater than ( - ) -adrenaline greater than ( - ) -alpha methylnoradrenaline greater than ( - ) -noradrenaline greater than ( +... | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
64,
77
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
431,
441
]
} |
activity coefficient of n-acetyl ethyl esters of aromatic amino acids in 2-fluoroethanol , 2,2,2-trifluoroethanol , 2-chloroethanol , 2-bromoethanol , 1-propanol , and ethanol . | NA | {
"id": "C0040983",
"name": "trifluoroethanol",
"pos": [
97,
113
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
168,
175
]
} |
satisfactory virus capsid antigen-specific and negative control antigens for the immune adherence hemagglutination assay were prepared from cell extracts of the epstein-barr virus producer p3hr-1 and the epstein-barr virus genome-negative bjab lymphoblastoid cell lines , respectively . | NA | {
"id": "C0003342",
"name": "virus",
"pos": [
13,
18
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
64,
72
]
} |
there appeared to be no relationship between the presence and extent of the cutaneous lesions and the observed seizure disorder , difficulty of seizure control , intellectual deficit , hemiparesis , homonymous hemianopsia , and intracranial calcification . | NA | {
"id": "C0014544",
"name": "seizure disorder",
"pos": [
111,
127
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
144,
151
]
} |
both the divalent cation ionophore , a23187 , and the monovalent cation ionophore , valinomycin , significantly enhance phosphatidylinositol transfer in the standard reaction mixture at concentrations 1 to 2 orders of magnitude greater than those sufficient for the ionophores to facilitate cation transport across membr... | NA | {
"id": "C0007448",
"name": "divalent cation",
"pos": [
9,
24
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
291,
297
]
} |
cultured rat glioma c-6 cells , with beta-adrenergic receptors , and human lung wi-38 cells , with prostaglandin receptors , were exposed to catecholamine ( isoproterenol ) and prostaglandin e1 , respectively , while their junctions were probed with microinjected fluorescent-labelled mono- , di- , and triglutamate . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
141,
154
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
157,
170
]
} |
the first phase was accompanied by a sharp rise of serum catecholamines ( 6-fold increase in adrenaline , and 4.5-fold increase in noradrenaline level ) and of indices of left ventricular contractility . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
93,
103
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
131,
144
]
} |
the swelling observed under these conditions is dependent on anions , giving a series ( from efficient anion to less efficient ones ) : i- greater than scn- greater than br- greater than cl- much greater than f- greater than glutamate , ethylsulfate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
61,
66
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
136,
137
]
} |
the swelling observed under these conditions is dependent on anions , giving a series ( from efficient anion to less efficient ones ) : i- greater than scn- greater than br- greater than cl- much greater than f- greater than glutamate , ethylsulfate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
61,
66
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
245,
246
]
} |
the effect of 1-propanol , 2-propanol , n-butanol , ethanol and methanol an sorbitol dehydrogenase activity was assayed . | NA | {
"id": "C0022237",
"name": "2-propanol",
"pos": [
27,
37
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
65,
72
]
} |
the effect of 1-propanol , 2-propanol , n-butanol , ethanol and methanol an sorbitol dehydrogenase activity was assayed . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
52,
59
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
64,
72
]
} |
third variable analysis : application to causal sequences among nutrient intake , maternal weight , birthweight , placental weight , and gestation . | NA | {
"id": "C0005612",
"name": "birthweight",
"pos": [
100,
111
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
124,
130
]
} |
the analysis of three-variable sets yielded strong inferences about the relations among caloric intake , maternal weight , birthweight , placental weight , and length of gestation . | NA | {
"id": "C0005612",
"name": "birthweight",
"pos": [
123,
134
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
147,
153
]
} |
of the components of the plasma kallikrein-kinin system the free ( spontaneous ) and kaolin-activated kallikrein ( prekallikrein ) activities , the concentration of bradykinin , the bradykinin splitting total kininase activity , total kallikrein-inhibitor activity and the concentration of alpha 2-macroglobulin , a majo... | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
32,
42
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
115,
128
]
} |
the depigmenting ability has been used as a treatment for acquired hyperpigmentary disorders , but adverse effects were observed -- irritation and local sensitization -- depigmentation locally and at a distance from the treated areas -- melanoleukodermia among asiatics -- no repigmentation : therefore treatment with mb... | NA | {
"id": "C0162835",
"name": "depigmentation",
"pos": [
170,
184
]
} | {
"id": "C0042900",
"name": "vitiligo",
"pos": [
360,
368
]
} |
as regards to the mechanism of these pigmentary disorders , knowledge is incomplete , particulary concerning depigmentation at a distance : hypothesis was : destruction by degrees of the melanocytes , as in lerner 's theory concerning vitiligo , autoimmune mechanism ? | NA | {
"id": "C0549567",
"name": "pigmentary disorders",
"pos": [
37,
57
]
} | {
"id": "C0162835",
"name": "depigmentation",
"pos": [
109,
123
]
} |
as regards to the mechanism of these pigmentary disorders , knowledge is incomplete , particulary concerning depigmentation at a distance : hypothesis was : destruction by degrees of the melanocytes , as in lerner 's theory concerning vitiligo , autoimmune mechanism ? | NA | {
"id": "C0162835",
"name": "depigmentation",
"pos": [
109,
123
]
} | {
"id": "C0042900",
"name": "vitiligo",
"pos": [
235,
243
]
} |
there were no significant findings due to diet for heart rate , blood pressure , serum electrolytes , subjective fatigue and urinary excretion of k+ , epinephrine and norepinephrine . body temperatures were lower ( p less than 0.05 ) for the crash diet than for the normal diet . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
151,
162
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
167,
181
]
} |
gallstones extracted by surgery were examined for ct density , which was compared with the x-ray-film , floating performance and chemical analysis of the stones . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
0,
10
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
154,
160
]
} |
alter a comprehensive introduction , intended to vocalize the pharmacologically-induced leukopenia problem , it is herein described an agranulocytosis case , rifamicin sv-induced , in an abdominal hodgkin subject . | NA | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
88,
98
]
} | {
"id": "C0001824",
"name": "agranulocytosis",
"pos": [
135,
150
]
} |
the pep4-3 mutation results in a 90-95 % reduction in the levels of five vacuolar hydrolases in yeast , including proteinases a and b , carboxypeptidase y , rnase ( s ) and the repressible alkaline phosphatase . | NA | {
"id": "C0020289",
"name": "hydrolases",
"pos": [
82,
92
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
114,
125
]
} |
as the results , out of the 39 cases of the present series , localization of cytoplasmic immunoglobulins in neoplastic cells was demonstrated in 20 cases with the pap method and in 28 with the emela method , and out of the 28 cases in which localization of cytoplasmic immunoglobulins was verified at the subcellular lev... | NA | {
"id": "C0003241",
"name": "emela",
"pos": [
193,
198
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
362,
371
]
} |
fsh treatment increased progesterone and 20 alpha-hydroxy-4-pregnen-3-one ( 20 alpha-oh-p ) production by 10.2- and 11-fold , respectively . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
24,
36
]
} | {
"id": "C0012311",
"name": "20 alpha-hydroxy-4-pregnen-3-one",
"pos": [
41,
73
]
} |
the synthesis of the amides and oxazolines of ursodeoxycholic acid , deoxycholic acid , hyodeoxycholic acid and cholic acid . | NA | {
"id": "C0042105",
"name": "ursodeoxycholic acid",
"pos": [
46,
66
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
91,
107
]
} |
e-2,2,3',3 '' ,5,5,5',5 '' -octadeuteriodiethylstilbestrol ( des-d8 ) and z-2,3 ' 3 '' ,4,5,5,5',5 '' -octadeuterio-3,4-bis ( p-hydroxyphenyl ) -2-hexene ( psi-des-d8 ) were synthesized from e-diethylstilbestrol ( des ) by hydrogen/deuterium exchange in a mixture of methanol-d and deuterium chloride in deuterium oxide ... | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
223,
231
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
304,
313
]
} |
e-2,2,3',3 '' ,5,5,5',5 '' -octadeuteriodiethylstilbestrol ( des-d8 ) and z-2,3 ' 3 '' ,4,5,5,5',5 '' -octadeuterio-3,4-bis ( p-hydroxyphenyl ) -2-hexene ( psi-des-d8 ) were synthesized from e-diethylstilbestrol ( des ) by hydrogen/deuterium exchange in a mixture of methanol-d and deuterium chloride in deuterium oxide ... | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
232,
241
]
} | {
"id": "C0011745",
"name": "deuterium",
"pos": [
304,
313
]
} |
additional confirmation of the positions of deuterium exchange in stilbestrols was obtained from an analysis of the oxidation of des-d8 to z , z-2,3',3 '' ,5,5',5 '' -hexadeuteriodienestrol ( beta-dies-d6 ) and of the hydrogen/deuterium exchange reaction of hexestrol ( hex ) to 3',3 '' ,5',5 '' -hexestrol , ( hex-d4 ) ... | NA | {
"id": "C0012203",
"name": "stilbestrols",
"pos": [
66,
78
]
} | {
"id": "C0019467",
"name": "hex",
"pos": [
311,
314
]
} |
additional confirmation of the positions of deuterium exchange in stilbestrols was obtained from an analysis of the oxidation of des-d8 to z , z-2,3',3 '' ,5,5',5 '' -hexadeuteriodienestrol ( beta-dies-d6 ) and of the hydrogen/deuterium exchange reaction of hexestrol ( hex ) to 3',3 '' ,5',5 '' -hexestrol , ( hex-d4 ) ... | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
218,
226
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
227,
236
]
} |
the distribution of vasotocin and isotocin in the brain of the rainbow trout salmo gairdneri was investigated by the unlabeled antibody enzyme method , by using purified antisera against arginine vasotocin and isotocin . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
127,
135
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
170,
178
]
} |
distribution of dopamine- , noradrenaline- , and adrenaline-containing cell bodies in the rat medulla oblongata : demonstrated by the immunocytochemical localization of catecholamine biosynthetic enzymes . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
28,
41
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
49,
59
]
} |
the detection of perikarya which show immunoreactivity for th , used in the biosynthesis of dopamine , noradrenaline , and adrenaline , but not dbh , which converts dopamine to noradrenaline , suggests the existence of dopamine-synthesizing neurons in the medulla . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
106,
116
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
177,
190
]
} |
all parameters of glycemic control evaluated ( including inpatient mean plasma glucose , mean amplitude of glycemic excursions , m-value , urinary glucose excretion ; glycosylated hemoglobin ; and outpatient blood glucose values ) showed marked improvement from baseline , yet no difference when the intensive regimens w... | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
79,
86
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
208,
221
]
} |
however , l dna formed in mg2+-etoh ( which we designate as z* dna ) has unique properties : a ) it can be sedimented readily out of solution at low speed , indicative of condensation and intermolecular aggregation ; | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
12,
15
]
} | {
"id": "C0043442",
"name": "z",
"pos": [
60,
61
]
} |
deposition of an intermediate form of procollagen type iii ( pn-collagen ) into fibrils in the matrix of amniotic epithelial cells . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
38,
49
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
64,
72
]
} |
since most of the aminopropeptide in the matrix appeared covalently linked as pn-collagen , we conclude that the deposition of this intermediate form of procollagen is a general mechanism in collagen type iii fibrillogenesis . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
81,
89
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
153,
164
]
} |
( b ) have strongly diverged from those coding for other intermediate filament proteins , since hybridization of the vimentin probe does not lead to a diagnostic multiband pattern ; | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
57,
87
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
117,
125
]
} |
despite the key role ca2+ plays in the nervous system , biochemical actions on neural tissue of the ca2+-regulating peptide hormones parathyrin and calcitonin were unknown . | NA | {
"id": "C0597192",
"name": "peptide hormones",
"pos": [
116,
132
]
} | {
"id": "C0030520",
"name": "parathyrin",
"pos": [
133,
143
]
} |
our recent observation that peptide hormones do indeed act on glial cells is extended by the present report that these cells respond to the calcaemic peptide hormones parathyrin and calcitonin . | NA | {
"id": "C0597192",
"name": "peptide hormones",
"pos": [
28,
44
]
} | {
"id": "C0030520",
"name": "parathyrin",
"pos": [
167,
177
]
} |
identification by rna-protein cross-linking of ribosomal proteins located at the interface between the small and the large subunits of mammalian ribosomes . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
22,
29
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
47,
65
]
} |
specific rabbit antibodies to z-dna were shown by radioimmunoassay and electron microscopy to react with form v dna of pbr322 . | NA | {
"id": "C0043442",
"name": "z-dna",
"pos": [
30,
35
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
112,
115
]
} |
pulse labeled sv40 rna is also associated with the nuclear matrix ( less than 15 % of the viral rna is removed by dnase and high salt ) . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
19,
22
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
90,
99
]
} |
single-stranded dna containing o6-methylguanine is a poor substrate , with the methyl transfer occurring at approximately 0.1 % of the rate for duplex dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
0,
19
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
151,
154
]
} |
the glycosaminoglycan part co-migrates upon thin layer electrophoresis with heparan sulphate and shows a chemical composition characteristic for this carbohydrate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
4,
21
]
} | {
"id": "C0019143",
"name": "heparan",
"pos": [
76,
83
]
} |
this antibody ( kg 8.13 ) binds to a determinant present in a large number of human cytokeratin polypeptides , notably some polypeptides ( nos . 1 , 5 , 6 , 7 , and 8 ) of the 'basic cytokeratin subfamily ' defined by peptide mapping , as well as a few acidic cytokeratins such as the epidermis-specific cytokeratins nos... | NA | {
"id": "C0010803",
"name": "cytokeratin",
"pos": [
84,
95
]
} | {
"id": "C1179970",
"name": "acidic cytokeratins",
"pos": [
253,
272
]
} |
the homologous single-stranded dna-binding proteins from calf thymus and from e. coli stimulate the respective holoenzymes and inhibit the core enzymes . | NA | {
"id": "C0282109",
"name": "holoenzymes",
"pos": [
111,
122
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
144,
151
]
} |
after incubation of the detergent-insoluble matrix of these cells with [ gamma-32p ] atp , several alkali-resistant phosphoproteins , including a very heavily labelled 55 000 mol . wt . protein ( p55 ) , have been detected in lstra , reflecting the activity of a protein kinase specific to this cell line . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
116,
131
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
263,
270
]
} |
alignment with partial data available for vimentin , glial fibrillary acid protein , neurofilament 68 k , two wool alpha-keratins , and a recently described dna clone covering 90 % of an epidermal keratin shows that all seven proteins have extensive homologies and therefore form a complex multigene family , the interme... | NA | {
"id": "C0010803",
"name": "keratin",
"pos": [
121,
128
]
} | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
313,
343
]
} |
the non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesenteric ganglia was depressed by bath application of met- or leu-enkephalin and enhanced by naloxone or naltrexone . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
181,
189
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
193,
203
]
} |
to characterize the fast component of axonal transport in regenerating goldfish optic axons , the incorporation of l-2,3- [ 3h ] proline into newly-synthesized proteins in the cell bodies of the retinal ganglion cells and the amount of transported labeled protein were determined at 2-36 days after cutting the optic tra... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
160,
168
]
} | {
"id": "C0007292",
"name": "transported",
"pos": [
236,
247
]
} |
this observation , together with the close topographical association of dopamine and met-enkephalin in the substantia nigra , further supports the likely existence of important functional relationships between dopaminergic and enkephalinergic neurons in the human brain . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
72,
80
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
210,
222
]
} |
in this study we measured the turnover of dopamine , norepinephrine and epinephrine in microdissected brain regions to identify some of the specific neural loci involved in this integration . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
53,
67
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
} |
dopamine , norepinephrine and epinephrine turnover was increased in ligated rats in nucleus tractus solitarius ( right and left ) , nucleus commissuralis , a1-region , locus coeruleus , nucleus cuneatus , and area postrema in the pons-medulla and nucleus dorsomedialis in the hypothalamus . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
11,
25
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
30,
41
]
} |
norepinephrine and dopamine ( but not epinephrine ) turnover was increased in nucleus ambiguus in the brain stem and nucleus paraventricularis in the hypothalamus . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
38,
49
]
} |
free and conjugated catecholamines ( dopamine , noradrenaline , adrenaline ) and their methoxylated and/or deaminated metabolites were studied in rat urine after the bilateral destruction of the a10 dopaminergic cell group . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
48,
61
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} |
in contrast , no changes were observed in the free and conjugated forms of urinary da , 3-methoxytyramine noradrenaline , normetanephrine , adrenaline , vanylmandelic acid , 3-methoxy-4-hydroxyphenylglycol and in the free forms of dopac and hva . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
106,
119
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
122,
137
]
} |
in contrast , no changes were observed in the free and conjugated forms of urinary da , 3-methoxytyramine noradrenaline , normetanephrine , adrenaline , vanylmandelic acid , 3-methoxy-4-hydroxyphenylglycol and in the free forms of dopac and hva . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
106,
119
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
140,
150
]
} |
the present report confirms and extends our previous findings on the relationships between central dopaminergic activity and urinary deaminated metabolites of da in the rat . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
99,
111
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
159,
161
]
} |
the effects of 3 cannabinoids , delta 9-tetrahydrocannabinol ( delta 9-thc ) , 11-oh-delta 9-tetrahydrocannabinol ( 11-oh-delta 9-thc ) and cannabidiol ( cbd ) on the binding of [ 3h ] dihydroalprenolol [ ( 3h ] dha ) to mouse brain beta-adrenergic receptors were determined . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
17,
29
]
} | {
"id": "C0039663",
"name": "delta 9-thc",
"pos": [
122,
133
]
} |
the single-stranded viral dna of an m13 phage recombinant containing the early promoter region of sv40 was hybridized with linear , double-stranded replicative form dna of a related m13 phage containing a short deletion in the cloned sv40 sequence . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
4,
19
]
} | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
132,
147
]
} |
the single-stranded region was filled in with dna polymerase i , which incorporates adenine opposite the mutated uracils , and the dna then transfected into the m13 host jm103 . viral dna from the resultant plaques was used for the rapid dideoxy-dna sequencing procedure ; | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
46,
49
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
178,
187
]
} |
dermatosparaxis is a genetic defect found in humans and animals , which affects the conversion of procollagen to collagen and aminopropeptides . under cell culture conditions a reduction of the release of aminopropeptides is paralleled by an increased synthesis of collagens type i and iii . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
98,
109
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
265,
273
]
} |
since the fragment families forming the major components of the mouse and human dnas derive from very long chromosomal segments , the isochores , the presence of actin genes on all components provides evidence for their dispersion in both genomes . | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
80,
84
]
} | {
"id": "C1135894",
"name": "isochores",
"pos": [
134,
143
]
} |
recombinant dna molecules comprising bovine papilloma virus type 1 dna linked to plasmid dna are maintained in a plasmidial state both in rodent fibroblasts and in bacterial cells . | NA | {
"id": "C0012931",
"name": "recombinant dna",
"pos": [
0,
15
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
89,
92
]
} |
transformed cells obtained after transfecting fr3t3 rat fibroblasts with dna of bovine papilloma virus type 1 ( bpv1 ) maintained only free copies of the viral genome . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
56,
67
]
} |
two monoclonal antibodies , each recognizing an idiotypic determinant ( idiotope ) in the variable region of antibody b1-8 , and fluorescence-activated cell sorting were used for the isolation of spontaneous somatic cell variants whose antibody product lacks the expression of one of the two idiotopes . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
4,
25
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
236,
244
]
} |
by this method , a subfamily of closely related cytokeratin polypeptides has been identified which comprises the relatively large ( greater than or equal to mol . wt . 52 500 in human cells ) and basic ( ph greater than or equal to 6.0 ) polypeptides but not the smaller and acidic cytokeratins . | NA | {
"id": "C0010803",
"name": "cytokeratin",
"pos": [
48,
59
]
} | {
"id": "C1179970",
"name": "acidic cytokeratins",
"pos": [
275,
294
]
} |
we conclude that the two viruses obtain their lipids from the plasma membrane in the same way and that the different phospholipid compositions of the viruses from polarized cells reflect differences in the phospholipid composition of the two plasma membrane domains . | NA | {
"id": "C0025249",
"name": "lipids",
"pos": [
46,
52
]
} | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
206,
218
]
} |
we devised a computer analysis which , by using this map , allows the localization of the mini-mu dna in a bacterial dna population . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
98,
101
]
} | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
107,
120
]
} |
furthermore , we have identified extended sequence homologies within the 23s rrna and l10 leader region rna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
77,
81
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
104,
107
]
} |
cells transformed by simian sarcoma virus ( ssv ) express a 115000-dalton protein ( p115 ) that is precipitated by a goat antiserum to disrupted ssv/ssav-infected and transformed cells but not by antibodies directed against the viral gag protein , p30 , or envelope proteins . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
122,
131
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
196,
206
]
} |
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