text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the interaction of apamin , a bee venom neurotoxin , with rat skeletal muscle cell membranes has been followed using both an electrophysiological and a biochemical approach . | NA | {
"id": "C0003521",
"name": "apamin",
"pos": [
19,
25
]
} | {
"id": "C0004920",
"name": "bee venom",
"pos": [
30,
39
]
} |
the unoccupied and the occupied cellular dnas and the adjacent viral dna exhibited a few short nucleotide homologies . | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
41,
45
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
63,
68
]
} |
it is likely that foreign ( viral ) dna can be inserted via short sequence homologies at many different sites of cellular dna . | NA | {
"id": "C0012939",
"name": "viral",
"pos": [
28,
33
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
122,
125
]
} |
a patient with rheumatoid arthritis developed gold induced peripheral neuropathy after 255 mgs of aurothioglucose . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
46,
50
]
} | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
98,
113
]
} |
the neurological manifestations were right facial nerve paralysis , paraesthesia of the right cheek and dysarthria . | NA | {
"id": "C0027854",
"name": "neurological manifestations",
"pos": [
4,
31
]
} | {
"id": "C0522224",
"name": "paralysis",
"pos": [
56,
65
]
} |
liver weights , liver microsomal protein , and cytochrome p450 content and the activities of microsomal ethylmorphine n-demethylase ( emnd ) , aniline hydroxylase ( anh ) , and arylhydrocarbon hydroxylase ( ahh ) were determined in control and bop-treated animals after 0 ( 0600 ) , 3 ( 0900 ) , 6 ( 1200 ) , 12 ( 1800 )... | NA | {
"id": "C0010762",
"name": "cytochrome p450",
"pos": [
47,
62
]
} | {
"id": "C0003927",
"name": "arylhydrocarbon hydroxylase",
"pos": [
177,
204
]
} |
liver weights , liver microsomal protein , and cytochrome p450 content and the activities of microsomal ethylmorphine n-demethylase ( emnd ) , aniline hydroxylase ( anh ) , and arylhydrocarbon hydroxylase ( ahh ) were determined in control and bop-treated animals after 0 ( 0600 ) , 3 ( 0900 ) , 6 ( 1200 ) , 12 ( 1800 )... | NA | {
"id": "C0003039",
"name": "aniline hydroxylase",
"pos": [
143,
162
]
} | {
"id": "C0003927",
"name": "arylhydrocarbon hydroxylase",
"pos": [
177,
204
]
} |
hepatic microsomal protein content , cytochrome p450 content , and aryl hydrocarbon hydroxylase ( ahh ) and aniline hydroxylase ( anh ) activities were measured after three weeks of feeding the diets . | NA | {
"id": "C0010762",
"name": "cytochrome p450",
"pos": [
37,
52
]
} | {
"id": "C0003927",
"name": "aryl hydrocarbon",
"pos": [
67,
83
]
} |
hepatic microsomal protein content , cytochrome p450 content , and aryl hydrocarbon hydroxylase ( ahh ) and aniline hydroxylase ( anh ) activities were measured after three weeks of feeding the diets . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon",
"pos": [
67,
83
]
} | {
"id": "C0003039",
"name": "aniline hydroxylase",
"pos": [
108,
127
]
} |
also the microsomal phospholipid contents were higher in those rats fed 2 % cholesterol diet than in those fed cholesterol-free diet and in the 2 % cholesterol group also phenobarbitone increased the phospholipid contents . | NA | {
"id": "C0008395",
"name": "cholesterol diet",
"pos": [
76,
92
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
148,
159
]
} |
the results demonstrated that dietary cholesterol has profound effects on the structure of microsomal membranes far beyond changes in their cholesterol content . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
30,
49
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
140,
151
]
} |
the influence of dietary cholesterol on drug metabolism was studied by feeding rats either a cholesterol-free or a high ( 2 % ) cholesterol diet for 4 weeks from weanling onward and giving phenobarbitone ( pb ) and/or carbon tetrachloride ( ccl4 ) thereafter . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
25,
36
]
} | {
"id": "C0008395",
"name": "cholesterol diet",
"pos": [
128,
144
]
} |
the cytochrome p-450 concentration was 2-fold in rats fed the 2 % cholesterol diet in comparison with those fed the cholesterol-free diet . | NA | {
"id": "C0008395",
"name": "cholesterol diet",
"pos": [
66,
82
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
116,
127
]
} |
the ppo hydroxylase activity was 2-fold in the livers of rats fed the 2 % cholesterol diet in comparison with those fed the cholesterol-free diet . | NA | {
"id": "C0008395",
"name": "cholesterol",
"pos": [
74,
85
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
124,
135
]
} |
the ethoxycoumarin o-deethylase activity was 2-fold in the livers of rats fed 2 % cholesterol diet from those fed the cholesterol-free diet . | NA | {
"id": "C0008395",
"name": "cholesterol diet",
"pos": [
82,
98
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
118,
129
]
} |
mar 18.5 , 80.2 , and 103.6 antibodies are of the gamma 2a kappa isotype , and bind strongly to protein a , allowing easy purification . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
28,
38
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
65,
72
]
} |
monoclonal antibody from clone 18.5 binds equally well to ig of both ri-1a and ri-1b allotypes , whereas 80.2 and 103.6 antibodies selectively bind to ri-1b . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
0,
19
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
120,
130
]
} |
these monoclonal antibodies can be fitc conjugated for use as a second antibody in indirect immunofluorescence assays , or radiolabeled for use in radio immunoassays requiring a specific antirat kappa antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
6,
27
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
201,
209
]
} |
using frozen tissue sections , a monoclonal antibody ( wi 691-13-17 ) known to detect an epitope common to all dr alloantigens on the beta ( light ) chain of dr antigens , and a two-step indirect immunoperoxidase technique , dr antigens were found on all metastatic lesions tested and on many primary tumors and their hi... | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
89,
96
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
228,
236
]
} |
on the other hand , using a hemagglutination test based on antibody induced agglutination of sheep red blood cells coated with hcg , it was shown that only pd3-mcab is capable of inducing a positive reaction , although both monoclonal antibodies have a similar binding capacity to the coated cells . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
59,
67
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
224,
245
]
} |
twenty-eight monoclonal antibodies ( moabs ) from the nih melanoma exchange program were analyzed in a binding assay for reactivity with a panel of 22 cell lines which included melanomas , carcinomas , fibroblasts , and lymphomyeloid cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
202,
213
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
234,
239
]
} |
twenty-four of the 30 monoclonal antibodies bound to the majority of melanoma cell lines tested , and only two antibodies did not bind to any of the melanoma lines . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
22,
43
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
111,
121
]
} |
the development of immunological agents ( i.e. , vaccines , toxoids , antitoxins ) for the prevention or treatment of aac would be a significant advance in therapy . | NA | {
"id": "C1579312",
"name": "immunological agents",
"pos": [
19,
39
]
} | {
"id": "C0042210",
"name": "vaccines",
"pos": [
49,
57
]
} |
the development of immunological agents ( i.e. , vaccines , toxoids , antitoxins ) for the prevention or treatment of aac would be a significant advance in therapy . | NA | {
"id": "C1579312",
"name": "immunological agents",
"pos": [
19,
39
]
} | {
"id": "C0040555",
"name": "toxoids",
"pos": [
60,
67
]
} |
the development of immunological agents ( i.e. , vaccines , toxoids , antitoxins ) for the prevention or treatment of aac would be a significant advance in therapy . | NA | {
"id": "C0042210",
"name": "vaccines",
"pos": [
49,
57
]
} | {
"id": "C0040555",
"name": "toxoids",
"pos": [
60,
67
]
} |
the implementation of the same allows the evaluation of the possibility , in subsequent times , of preparing , therefore standardizing , replicated allergenic extracts , similar to the former insofar as the allergenic and antigenic characteristics are concerned . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
148,
158
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
222,
231
]
} |
in this study we have evaluated the antibacterial activity of six cephalosporins of the first generation ( cephacetrile , cephalothin , cefazolin , cephaloridin , cephalexin , cephradine ) two cephalosporin of the second generation ( cefoxitin and cefuroxime ) and two of the third generation ( cefotaxime and cefoperazo... | NA | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
107,
119
]
} | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
122,
133
]
} |
in this study we have evaluated the antibacterial activity of six cephalosporins of the first generation ( cephacetrile , cephalothin , cefazolin , cephaloridin , cephalexin , cephradine ) two cephalosporin of the second generation ( cefoxitin and cefuroxime ) and two of the third generation ( cefotaxime and cefoperazo... | NA | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
107,
119
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
295,
305
]
} |
in this study we have evaluated the antibacterial activity of six cephalosporins of the first generation ( cephacetrile , cephalothin , cefazolin , cephaloridin , cephalexin , cephradine ) two cephalosporin of the second generation ( cefoxitin and cefuroxime ) and two of the third generation ( cefotaxime and cefoperazo... | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
163,
173
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
176,
186
]
} |
in this study we have evaluated the antibacterial activity of six cephalosporins of the first generation ( cephacetrile , cephalothin , cefazolin , cephaloridin , cephalexin , cephradine ) two cephalosporin of the second generation ( cefoxitin and cefuroxime ) and two of the third generation ( cefotaxime and cefoperazo... | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
248,
258
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
295,
305
]
} |
[ minimal inhibitory and bactericidal concentrations of cefoperazone , cefotaxime , cefuroxime and cefalotin against 90 bacterial strains ] . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
71,
81
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
84,
94
]
} |
in this work , the sensitivity in vitro of cefoxitin , cefuroxime , cefotaxime , cefoperazone and cephalothin have been examined . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
55,
65
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
68,
78
]
} |
the m. chelonei-like organisms were most susceptible to ampicillin , doxycycline , minocycline , amikacin , erythromycin , sulfamethoxazole , and sulfamethoxazole-trimethoprim . | NA | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
123,
139
]
} | {
"id": "C0041044",
"name": "sulfamethoxazole-trimethoprim",
"pos": [
146,
175
]
} |
the third-generation cephalosporins cefotaxime and moxalactam were substantially more inhibitory than were cefoperazone , cefamandole , and cefoxitin . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
107,
119
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
122,
133
]
} |
determination of minimal inhibitory concentrations revealed high resistance to the 4,6-substituted deoxystreptamine aminoglycosides amikacin , gentamicin , kanamycin , netilmicin , sisomicin , and tobramycin and also to lividomycin a and hygromycin b , but susceptibility to streptomycin , dihydrostreptomycin , paromomy... | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
116,
131
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
143,
153
]
} |
determination of minimal inhibitory concentrations revealed high resistance to the 4,6-substituted deoxystreptamine aminoglycosides amikacin , gentamicin , kanamycin , netilmicin , sisomicin , and tobramycin and also to lividomycin a and hygromycin b , but susceptibility to streptomycin , dihydrostreptomycin , paromomy... | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
116,
131
]
} | {
"id": "C0020406",
"name": "hygromycin b",
"pos": [
238,
250
]
} |
determination of minimal inhibitory concentrations revealed high resistance to the 4,6-substituted deoxystreptamine aminoglycosides amikacin , gentamicin , kanamycin , netilmicin , sisomicin , and tobramycin and also to lividomycin a and hygromycin b , but susceptibility to streptomycin , dihydrostreptomycin , paromomy... | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
116,
131
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
297,
309
]
} |
determination of minimal inhibitory concentrations revealed high resistance to the 4,6-substituted deoxystreptamine aminoglycosides amikacin , gentamicin , kanamycin , netilmicin , sisomicin , and tobramycin and also to lividomycin a and hygromycin b , but susceptibility to streptomycin , dihydrostreptomycin , paromomy... | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
132,
140
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
156,
165
]
} |
determination of minimal inhibitory concentrations revealed high resistance to the 4,6-substituted deoxystreptamine aminoglycosides amikacin , gentamicin , kanamycin , netilmicin , sisomicin , and tobramycin and also to lividomycin a and hygromycin b , but susceptibility to streptomycin , dihydrostreptomycin , paromomy... | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
143,
153
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
181,
190
]
} |
determination of minimal inhibitory concentrations revealed high resistance to the 4,6-substituted deoxystreptamine aminoglycosides amikacin , gentamicin , kanamycin , netilmicin , sisomicin , and tobramycin and also to lividomycin a and hygromycin b , but susceptibility to streptomycin , dihydrostreptomycin , paromomy... | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
168,
178
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
181,
190
]
} |
determination of minimal inhibitory concentrations revealed high resistance to the 4,6-substituted deoxystreptamine aminoglycosides amikacin , gentamicin , kanamycin , netilmicin , sisomicin , and tobramycin and also to lividomycin a and hygromycin b , but susceptibility to streptomycin , dihydrostreptomycin , paromomy... | NA | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
312,
323
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
330,
338
]
} |
the characterization of the inhibitor showed that it was a lipoprotein or a lipid-associated-protein and that the protein component could be separated from the lipids when chromatographed on ultrogel aca 54 in the presence of urea . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
59,
70
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
160,
166
]
} |
seven strains of listeriae were inhibited but not killed by erythromycin , penicillin g , or ampicillin when tested by a microtiter broth dilution method . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
75,
87
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
93,
103
]
} |
quantitative killing studies performed with erythromycin combined with either penicillin g or ampicillin yielded antagonism for all strains , in contrast to microtiter checkerboard determinations , which did not indicate antagonism in all instances . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
78,
90
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
94,
104
]
} |
the antibacterial activity of n-formimidoyl thienamycin ( mk0787 ) was evaluated in 335 clinical isolates of ampicillin-resistant enterobacteriaceae , 50 pseudomonas aeruginosa strains , 28 acinetobacter spp. , 50 streptococcus faecalis strains , and 7 oxacillin-resistant staphylococcus aureus strains and was compared ... | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
109,
119
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
372,
383
]
} |
the antibacterial activity of n-formimidoyl thienamycin ( mk0787 ) was evaluated in 335 clinical isolates of ampicillin-resistant enterobacteriaceae , 50 pseudomonas aeruginosa strains , 28 acinetobacter spp. , 50 streptococcus faecalis strains , and 7 oxacillin-resistant staphylococcus aureus strains and was compared ... | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
386,
396
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
427,
437
]
} |
it had activity similar to that of cefotaxime and ceftizoxime against group a and b streptococci and streptococcus pneumoniae . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
35,
45
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
50,
61
]
} |
cefmenoxime had activity similar to that of cefotaxime , ceftizoxime , ceftazidime , and moxalactam against escherichia coli , citrobacter diversus , klebsiella , proteus mirabilis , salmonella , and shigella . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
0,
11
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
44,
54
]
} |
cefmenoxime had activity similar to that of cefotaxime , ceftizoxime , ceftazidime , and moxalactam against escherichia coli , citrobacter diversus , klebsiella , proteus mirabilis , salmonella , and shigella . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
44,
54
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
57,
68
]
} |
cefmenoxime was somewhat less active than moxalactam or ceftizoxime against enterobacter cloacae , enterobacter aerogenes , and enterobacter agglomerans , but was more active than cefotaxime , ceftizoxime , or ceftazidime against morganella ( minimum inhibitory concentration for 90 % of isolates , 0.1 microgram/ml . ) ... | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
0,
11
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
180,
190
]
} |
cefmenoxime was somewhat less active than moxalactam or ceftizoxime against enterobacter cloacae , enterobacter aerogenes , and enterobacter agglomerans , but was more active than cefotaxime , ceftizoxime , or ceftazidime against morganella ( minimum inhibitory concentration for 90 % of isolates , 0.1 microgram/ml . ) ... | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
180,
190
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
193,
204
]
} |
it was stable to most chromosomally mediated beta-lactamases , which act primarily as cephalosporinases , but was hydrolyzed by bacteroides and acinetobacter . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
45,
60
]
} | {
"id": "C0728805",
"name": "cephalosporinases",
"pos": [
86,
103
]
} |
the in vitro activity of ceftriaxone was compared with those of other recently introduced beta-lactam antimicrobial agents ( cefoperazone , cefotaxime , and moxalactam ) and with those of cefoxitin , clindamycin , and metronidazole against 227 strains of anaerobic bacteria . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
25,
36
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
140,
150
]
} |
the factors evaluated were : 1 ) types of seizures , 2 ) age of onset of seizures , 3 ) kind of therapy , 4 ) severity of seizure disorder , 5 ) age of the last seizure , 6 ) duration of therapy , 7 ) seizure-free period before drug withdrawal , 8 ) age of interruption of anticonvulsive therapy , 9 ) kind of discontinu... | NA | {
"id": "C0014544",
"name": "seizure disorder",
"pos": [
122,
138
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
201,
208
]
} |
the infusion of extra calcium did not prevent naf-induced cardiovascular failure but decreased plasma fluoride levels and increased the lethal dose of naf by 17 % ( not significant ) . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
102,
110
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
151,
154
]
} |
to determine whether protein excretion during exercise is an earlier sign of renal dysfunction in diabetic adolescents than the basal measurements , urinary creatinine , total proteins , albumin , and beta 2-microglobulin were studied before , immediately after , and 30 min after exercise until exhaustion on a bicycle ... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
21,
28
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
187,
194
]
} |
to assess whether human insulin ( recombinant dna ) is superior to porcine insulin , we compared the biologic effect of these two insulin preparations on rat and human adipocyte lipogenesis in vitro . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
18,
31
]
} | {
"id": "C0021641",
"name": "insulin preparations",
"pos": [
130,
150
]
} |
to assess whether human insulin ( recombinant dna ) is superior to porcine insulin , we compared the biologic effect of these two insulin preparations on rat and human adipocyte lipogenesis in vitro . | NA | {
"id": "C0724601",
"name": "porcine",
"pos": [
67,
74
]
} | {
"id": "C0021641",
"name": "insulin preparations",
"pos": [
130,
150
]
} |
after maintenance on purified pork or mixed beef-pork insulins ( ppi or mbp ) for a minimum of 6 mo , 116 patients were either switched to human insulin or maintained on their previous insulin . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
139,
152
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
185,
192
]
} |
the sera of insulin-resistant diabetic patients ( n = 4 ) , containing very high igg-insulin immunoglobulins , showed a significantly lower affinity for human insulin compared with porcine insulin ( p less than 0.01 ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
12,
19
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
153,
166
]
} |
the sera of insulin-resistant diabetic patients ( n = 4 ) , containing very high igg-insulin immunoglobulins , showed a significantly lower affinity for human insulin compared with porcine insulin ( p less than 0.01 ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
12,
19
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
181,
196
]
} |
insulin-specific igg and ige antibody response in type i diabetic subjects exclusively treated with human insulin ( recombinant dna ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
100,
113
]
} |
in seven type i diabetic individuals who were exclusively treated with human insulin ( recombinant dna ) each month , sera were examined for the development of insulin-specific igg and ige antibodies . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
71,
84
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
160,
167
]
} |
in patients initially treated with beef insulin there was no significant change in the mean blood glucose , the 'm ' index , the total daily insulin dose , or the frequency of hypoglycemic attacks after the change to human insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
40,
47
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
217,
230
]
} |
in pork insulin-treated patients greater values while on human insulin were found for mean glucose ( 9.0 mmol/l [ pork ] versus 9.7 mmol/l [ human insulin ] , p = 0.05 ) , 'm ' index ( 65.0 [ pork ] versus 79.6 [ human insulin ] , p less than 0.025 ) , and total daily insulin dose ( 50.9 u/day [ pork ] versus 52.5 u/da... | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
8,
15
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
324,
337
]
} |
these limited data are consistent with the conclusion that nph human insulin is slightly shorter acting than its animal insulin counterparts . | NA | {
"id": "C0795633",
"name": "nph human insulin",
"pos": [
59,
76
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
120,
127
]
} |
in two double-blind studies 66 insulin-dependent diabetic subjects pretreated with pork insulin were changed to human insulin ( recombinant dna ) or a purified pork insulin preparation ( regular and nph insulin ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
31,
38
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
112,
125
]
} |
sixty-five patients previously pretreated with beef insulin were transferred , in a randomized , double-blind fashion , to human insulin and purified beef insulin of the same preparations ( regular and nph insulin ) . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
123,
136
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
206,
213
]
} |
thirty-eight insulin-dependent diabetic subjects were treated for periods ranging from 1 to 14 mo with human insulin ( recombinant dna ) in order to investigate the clinical effects of human insulin in comparison with pork insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
13,
20
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
185,
198
]
} |
intradermal desensitization with human insulin ( recombinant dna ) in a patient with severe allergic skin reaction due to insulin . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
33,
46
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
122,
129
]
} |
skin testing with regular human insulin was positive , but not with nph human insulin alone . | NA | {
"id": "C0795635",
"name": "regular",
"pos": [
18,
25
]
} | {
"id": "C0795633",
"name": "nph human insulin",
"pos": [
68,
85
]
} |
we observed that by changing from either purified bovine or purified porcine insulin to human insulin given by csii , there is a gradual decrease in cia detectable after 3 wk and more pronounced 3 mo after changing . | NA | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
69,
84
]
} | {
"id": "C0021641",
"name": "cia",
"pos": [
149,
152
]
} |
this patient 's case shows that human insulin can be considered as an alternative treatment for immune-mediated insulin resistance . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
32,
45
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
112,
119
]
} |
there was no significant difference between insulin concentrations after human insulin and ppi given by either low- or high-dose intravenous infusion , except that high-dose ppi values ( 55-110 min ) were slightly but significantly higher after high-dose intravenous infusion . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
44,
51
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
73,
86
]
} |
the role of proinsulin as an alternate route to human insulin , and as a new treatment for diabetes when used alone or in combination with human insulin or connecting peptide , warrants further investigation . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
12,
22
]
} | {
"id": "C0006558",
"name": "connecting peptide",
"pos": [
156,
174
]
} |
although all investigations were performed under identical experimental conditions and equal dosages of each insulin were injected , higher insulin concentrations and a stronger biologic effect , shown by larger amount of dextrose delivered , were observed in both human insulins than in porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
109,
116
]
} | {
"id": "C0795635",
"name": "human insulins",
"pos": [
265,
279
]
} |
although all investigations were performed under identical experimental conditions and equal dosages of each insulin were injected , higher insulin concentrations and a stronger biologic effect , shown by larger amount of dextrose delivered , were observed in both human insulins than in porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
109,
116
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
288,
303
]
} |
after 2 wk of good control 9 type i diabetic patients were hospitalized and treated in a randomized fashion with different human insulin mixtures ( regular : nph ) , containing 10 , 15 , or 20 % regular insulin . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
123,
136
]
} | {
"id": "C0021641",
"name": "regular insulin",
"pos": [
195,
210
]
} |
comparison of the activity profiles of two fixed combinations of regular/nph human insulin ( recombinant dna ) of different compositions with a fixed regular/nph porcine insulin combination ( ppi ) in insulin-dependent diabetic individuals . | NA | {
"id": "C0795635",
"name": "regular",
"pos": [
65,
72
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
201,
208
]
} |
comparison of the activity profiles of two fixed combinations of regular/nph human insulin ( recombinant dna ) of different compositions with a fixed regular/nph porcine insulin combination ( ppi ) in insulin-dependent diabetic individuals . | NA | {
"id": "C0724601",
"name": "ppi",
"pos": [
192,
195
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
201,
208
]
} |
in a randomized double-blind crossover study , 10 insulin-dependent diabetic individuals were treated with a commercial brand of neutral , highly purified porcine insulin ( ppi ) with 30 % regular and 70 % nph fractions ( mixtard , nordisk , denmark ) , and with human insulins ( recombinant dna ) with 20 % regular and ... | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
50,
57
]
} | {
"id": "C0795635",
"name": "human insulins",
"pos": [
263,
277
]
} |
nevertheless , the activity of nph human insulin seems faster and more pronounced since minimal glycemia is lower and more rapidly reached after human insulin . | NA | {
"id": "C0795633",
"name": "nph human insulin",
"pos": [
31,
48
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
145,
158
]
} |
the study was concerned with the comparison of the action profile of regular and nph preparations of human insulin ( recombinant dna ) and of ppi ( pork purified insulin ) . | NA | {
"id": "C0795633",
"name": "nph preparations",
"pos": [
81,
97
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
162,
169
]
} |
thus , in previously treated patients with insulin-dependent diabetes , undergoing brief but intensive insulin therapy with continuous subcutaneous insulin infusion , human insulin is as clinically efficacious as ppi . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
43,
50
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
167,
180
]
} |
thus , in previously treated patients with insulin-dependent diabetes , undergoing brief but intensive insulin therapy with continuous subcutaneous insulin infusion , human insulin is as clinically efficacious as ppi . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
43,
50
]
} | {
"id": "C0724601",
"name": "ppi",
"pos": [
213,
216
]
} |
the delayed increments of glucagon under human insulin following arginine stimulation may be the result of a more rapid insulin absorption from subcutaneous tissue and a greater biologic action of this insulin in comparison with the ppi . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
41,
54
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
202,
209
]
} |
the delayed increments of glucagon under human insulin following arginine stimulation may be the result of a more rapid insulin absorption from subcutaneous tissue and a greater biologic action of this insulin in comparison with the ppi . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
47,
54
]
} | {
"id": "C0724601",
"name": "ppi",
"pos": [
233,
236
]
} |
the responsiveness of a growth-regulated rat 3y1 cell line and five clones of 3y1 cells transformed by the highly oncogenic human adenovirus type 12 to the catecholamine hormone ( - ) -isoproterenol was studied . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
156,
169
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
185,
198
]
} |
the other 10 subclones contained exclusively integrated viral dna sequences , as shown by the blot hybridization of high-molecular-weight cell dna which was uncleaved or digested with hincii , for which there are no sites in viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
62,
65
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
225,
234
]
} |
this is necessary if there is a dose-dependency in the animal above which saturation may occur and the plasma half-life kinetics change , or shifts occur either in the metabolic pathways of degradation and/or in the route of excretion from the body . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
110,
119
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
120,
128
]
} |
adherent cells per milliliter of blood , per total cells , and per mononuclear cells or monocytes plated were markedly diminished in the peripheral blood mononuclear cells of 44 melanoma , 23 breast cancer , 18 lung cancer , nine colon cancer , and 27 leukemia patients . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
9,
14
]
} | {
"id": "C1321301",
"name": "peripheral",
"pos": [
137,
147
]
} |
it represents an interesting substrate for protein upgrading through fermentation by cellulolytic organisms , because of the high content of cellulose and hemicellulose , with small amounts of protein and lignin ( table 1 ) . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
141,
150
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
205,
211
]
} |
2 ) the number of epitopes in the particle , and 3 ) the size of the antigen particles . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
18,
26
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
69,
76
]
} |
the amyloid failed to react with antiserums to amyloid fibril protein asc1 or human prealbumin , proteins previous demonstrated in generalized senile cardiac amyloid . | NA | {
"id": "C1456454",
"name": "amyloid",
"pos": [
4,
11
]
} | {
"id": "C0002716",
"name": "amyloid",
"pos": [
158,
165
]
} |
the most frequent pattern ( in approximately 46.6 % of patients with arthritis ) was sacroiliitis , usually non-destructive and either uni- or bilateral . | NA | {
"id": "C0003864",
"name": "arthritis",
"pos": [
69,
78
]
} | {
"id": "C0574960",
"name": "sacroiliitis",
"pos": [
85,
97
]
} |
fetal weight ( day 18 of gestation ) and postpartum pup weight ( 21 , 29 and 42 days post conception ) were determined . | NA | {
"id": "C0751992",
"name": "fetal weight",
"pos": [
0,
12
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
56,
62
]
} |
( c ) after induction the human beta-globin gene is converted from a dnase i insensitive or closed structure to a dnase i open configuration , while the human gamma-globin gene remains closed ; | NA | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
32,
43
]
} | {
"id": "C0017033",
"name": "gamma-globin",
"pos": [
159,
171
]
} |
furthermore , our results indicate that the ribosomal protein product of the human emtb gene is incorporated into functional ribosomes in place of the human corresponding chinese hamster protein , raising several interesting questions concerning the coordinate regulation of genes encoding ribosomal proteins in mammalia... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
54,
61
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
290,
308
]
} |
several abnormalities have been reported in dmd fibroblasts , suggesting that the genetic abnormality is expressed in these cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
48,
59
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} |
to search for potentially mutant protein ( s ) we have compared the protein composition of normal and dmd fibroblasts by two-dimensional gel electrophoresis and have now found one protein spot consistently missing in dmd cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
106,
117
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
221,
226
]
} |
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